SIMILAR PATTERNS OF AMINO ACIDS FOR 4Z4G_A_IPHA903_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flc HAEMAGGLUTININ-ESTER
ASE-FUSION
GLYCOPROTEIN
HAEMAGGLUTININ-ESTER
ASE-FUSION
GLYCOPROTEIN

(Influenza C
virus;
Influenza C
virus) 		PF02710
(Hema_HEFG)
PF03996
(Hema_esterase)
PF08720
(Hema_stalk) 		4 LEU B  80
PRO A 393
GLU B  85
TYR A 390
 None
 1.07A 4z4gA-1flcB:
undetectable		 4z4gA-1flcB:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h6d PRECURSOR FORM OF
GLUCOSE-FRUCTOSE
OXIDOREDUCTASE

(Zymomonas
mobilis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 LEU A 114
TYR A 137
LYS A 135
GLU A 112
 None
 1.27A 4z4gA-1h6dA:
4.1		 4z4gA-1h6dA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i6a HYDROGEN
PEROXIDE-INDUCIBLE
GENES ACTIVATOR

(Escherichia
coli) 		PF03466
(LysR_substrate) 		4 LEU A 105
TYR A 104
PRO A 107
GLU A 126
 None
 1.25A 4z4gA-1i6aA:
undetectable		 4z4gA-1i6aA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iug PUTATIVE ASPARTATE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00266
(Aminotran_5) 		4 LEU A 127
PRO A  81
GLU A 131
TYR A  83
 None
 1.13A 4z4gA-1iugA:
0.0		 4z4gA-1iugA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1knb ADENOVIRUS TYPE 5
FIBER PROTEIN

(Human
mastadenovirus
C) 		PF00541
(Adeno_knob) 		4 LYS A 528
PRO A 529
GLU A 566
TYR A 563
 None
 0.98A 4z4gA-1knbA:
undetectable		 4z4gA-1knbA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kz7 GUANINE NUCLEOTIDE
EXCHANGE FACTOR DBS

(Mus musculus) 		PF00169
(PH)
PF00621
(RhoGEF) 		4 LEU A 651
PRO A 768
GLU A 644
TYR A 647
 None
 1.24A 4z4gA-1kz7A:
undetectable		 4z4gA-1kz7A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m3u 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE

(Escherichia
coli) 		PF02548
(Pantoate_transf) 		4 LEU A 213
LYS A 231
GLU A 250
TYR A 256
 None
 1.03A 4z4gA-1m3uA:
undetectable		 4z4gA-1m3uA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nty TRIPLE FUNCTIONAL
DOMAIN PROTEIN

(Homo sapiens) 		PF00169
(PH)
PF00621
(RhoGEF) 		4 LEU A1252
PRO A1366
GLU A1245
TYR A1248
 None
 1.24A 4z4gA-1ntyA:
undetectable		 4z4gA-1ntyA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhv PROTEIN (ADENOVIRUS
FIBRE)

(Human
mastadenovirus
C) 		PF00541
(Adeno_knob) 		4 LYS A 528
PRO A 529
GLU A 567
TYR A 564
 None
 1.07A 4z4gA-1qhvA:
undetectable		 4z4gA-1qhvA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qiu ADENOVIRUS FIBRE

(Human
mastadenovirus
C) 		PF00541
(Adeno_knob)
PF00608
(Adeno_shaft) 		4 LYS A 528
PRO A 529
GLU A 567
TYR A 564
 None
 1.09A 4z4gA-1qiuA:
undetectable		 4z4gA-1qiuA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uax RIBONUCLEASE HII

(Pyrococcus
horikoshii) 		PF01351
(RNase_HII) 		4 LEU A  92
LYS A  98
PRO A  99
TYR A 124
 None
 1.20A 4z4gA-1uaxA:
6.8		 4z4gA-1uaxA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1upx HYDROXYLAMINE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF03063
(Prismane) 		4 LYS A 313
PRO A 312
GLU A 296
TYR A 316
 None
 1.16A 4z4gA-1upxA:
4.1		 4z4gA-1upxA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6t HYPOTHETICAL UPF0271
PROTEIN PH0986

(Pyrococcus
horikoshii) 		PF03746
(LamB_YcsF) 		4 LEU A 141
LYS A 109
PRO A 110
GLU A 163
 None
 1.12A 4z4gA-1v6tA:
2.3		 4z4gA-1v6tA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
METHANOL
DEHYDROGENASE
SUBUNIT 2

(Methylobacterium
extorquens;
Methylobacterium
extorquens) 		PF01011
(PQQ)
PF13360
(PQQ_2)
PF02315
(MDH) 		4 TYR B1001
LYS B1016
PRO B1017
GLU A 267
 None
 1.28A 4z4gA-1w6sB:
undetectable		 4z4gA-1w6sB:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wv9 RHODANESE HOMOLOG
TT1651

(Thermus
thermophilus) 		no annotation 4 LEU A  56
PRO A  52
GLU A  76
TYR A  78
 None
 1.28A 4z4gA-1wv9A:
undetectable		 4z4gA-1wv9A:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xi8 MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN

(Pyrococcus
furiosus) 		PF00994
(MoCF_biosynth)
PF03453
(MoeA_N)
PF03454
(MoeA_C) 		4 LEU A 315
LYS A 182
PRO A 183
GLU A 221
 None
 1.01A 4z4gA-1xi8A:
4.6		 4z4gA-1xi8A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xw8 UPF0271 PROTEIN YBGL

(Escherichia
coli) 		PF03746
(LamB_YcsF) 		4 LEU A 136
LYS A 104
PRO A 105
GLU A 158
 None
 1.25A 4z4gA-1xw8A:
2.4		 4z4gA-1xw8A:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3

(Thermoplasma
acidophilum) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 LEU A 461
LYS A 401
PRO A 402
TYR A 364
 None
 0.89A 4z4gA-1z1wA:
3.0		 4z4gA-1z1wA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ani RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA SUBUNIT

(Chlamydia
trachomatis) 		PF00268
(Ribonuc_red_sm) 		4 LEU A  20
LYS A  18
GLU A 108
TYR A  36
 None
 1.06A 4z4gA-2aniA:
undetectable		 4z4gA-2aniA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2asn NITROPHORIN 2

(Rhodnius
prolixus) 		PF02087
(Nitrophorin) 		4 LEU X  79
LYS X   9
PRO X   8
GLU X 110
 None
 1.31A 4z4gA-2asnX:
undetectable		 4z4gA-2asnX:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
METHANOL
DEHYDROGENASE SMALL
SUBUNIT

(Hyphomicrobium
denitrificans;
Hyphomicrobium
denitrificans) 		PF01011
(PQQ)
PF13360
(PQQ_2)
PF02315
(MDH) 		4 TYR B   1
LYS B  16
PRO B  17
GLU A 267
 None
 1.31A 4z4gA-2d0vB:
undetectable		 4z4gA-2d0vB:
6.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfa HYPOTHETICAL UPF0271
PROTEIN TTHB195

(Thermus
thermophilus) 		PF03746
(LamB_YcsF) 		4 LEU A 141
LYS A 109
PRO A 110
GLU A 163
 None
 1.26A 4z4gA-2dfaA:
undetectable		 4z4gA-2dfaA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eer NAD-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A 131
TYR A 129
PRO A  21
GLU A  76
 None
 1.09A 4z4gA-2eerA:
undetectable		 4z4gA-2eerA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g8g CAPSID

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		4 LEU A 341
TYR A 343
PRO A 342
TYR A 366
 None
 1.26A 4z4gA-2g8gA:
undetectable		 4z4gA-2g8gA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hwk HELICASE NSP2

(Venezuelan
equine
encephalitis
virus) 		PF01707
(Peptidase_C9) 		4 LEU A 776
TYR A 774
GLU A 730
TYR A 724
 None
 1.25A 4z4gA-2hwkA:
undetectable		 4z4gA-2hwkA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjf L-LYSINE EPSILON
AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00202
(Aminotran_3) 		4 LEU A 335
LYS A  92
PRO A  93
GLU A 126
 None
 0.95A 4z4gA-2jjfA:
undetectable		 4z4gA-2jjfA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l57 UNCHARACTERIZED
PROTEIN

(Clostridium
perfringens) 		PF13098
(Thioredoxin_2) 		4 LEU A  48
TYR A  50
LYS A  46
GLU A  43
 None
 1.18A 4z4gA-2l57A:
undetectable		 4z4gA-2l57A:
10.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2liv LEUCINE

(Escherichia
coli) 		PF13458
(Peripla_BP_6) 		4 LEU A 154
TYR A 199
PRO A 225
TYR A 150
 None
 1.32A 4z4gA-2livA:
4.9		 4z4gA-2livA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pef SERINE PROTEASE
INHIBITOR

(Caldanaerobacter
subterraneus) 		PF00079
(Serpin) 		4 LEU A 422
LYS A 315
PRO A 314
GLU A 245
 None
 1.25A 4z4gA-2pefA:
undetectable		 4z4gA-2pefA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgn RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 25

(Homo sapiens) 		PF00621
(RhoGEF) 		4 LEU B 179
PRO B 291
GLU B 172
TYR B 175
 None
 1.22A 4z4gA-2rgnB:
undetectable		 4z4gA-2rgnB:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgz HEME OXYGENASE 2

(Homo sapiens) 		PF01126
(Heme_oxygenase) 		4 LEU A  97
TYR A  98
PRO A  96
GLU A 102
 None
 1.21A 4z4gA-2rgzA:
undetectable		 4z4gA-2rgzA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE

(Escherichia
coli) 		PF01276
(OKR_DC_1)
PF03709
(OKR_DC_1_N)
PF03711
(OKR_DC_1_C) 		4 LEU A 262
LYS A 268
PRO A 269
GLU A 667
 None
 1.32A 4z4gA-2vycA:
3.1		 4z4gA-2vycA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xu2 UPF0271 PROTEIN
PA4511

(Pseudomonas
aeruginosa) 		PF03746
(LamB_YcsF) 		4 LEU A 147
TYR A 113
PRO A 116
GLU A 172
 None
 1.15A 4z4gA-2xu2A:
2.8		 4z4gA-2xu2A:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yk6 CMP-N-ACETYLNEURAMIN
ATE-BETA-GALACTOSAMI
DE-ALPHA-2,3-SIALYLT
RANSFERASE

(Neisseria
meningitidis) 		PF07922
(Glyco_transf_52) 		4 LEU A 344
LYS A 340
PRO A 341
GLU A 346
 None
 1.28A 4z4gA-2yk6A:
3.2		 4z4gA-2yk6A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1p RIBOSOME MATURATION
FACTOR RIMM

(Thermus
thermophilus) 		PF01782
(RimM)
PF05239
(PRC) 		4 LEU A  19
TYR A  13
PRO A  12
GLU A  52
 None
 1.14A 4z4gA-3a1pA:
undetectable		 4z4gA-3a1pA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2q 6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE

(Arthrobacter
sp. KI72) 		PF01425
(Amidase) 		4 LEU A 115
TYR A  69
PRO A  68
GLU A  56
 None
 1.20A 4z4gA-3a2qA:
undetectable		 4z4gA-3a2qA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3adg F21M12.9 PROTEIN

(Arabidopsis
thaliana) 		PF00035
(dsrm) 		4 LEU A  20
PRO A  32
GLU A  71
TYR A  34
 None
 1.31A 4z4gA-3adgA:
undetectable		 4z4gA-3adgA:
6.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3adr PUTATIVE
UNCHARACTERIZED
PROTEIN ST1585

(Sulfurisphaera
tokodaii) 		PF00753
(Lactamase_B) 		4 LEU A 142
TYR A 144
LYS A  81
GLU A 128
 None
 1.06A 4z4gA-3adrA:
undetectable		 4z4gA-3adrA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bol 5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE

(Thermotoga
maritima) 		PF00809
(Pterin_bind)
PF02574
(S-methyl_trans) 		4 LEU A 479
LYS A 484
PRO A 485
GLU A 482
 None
 1.14A 4z4gA-3bolA:
2.6		 4z4gA-3bolA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dg8 BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
falciparum) 		PF00186
(DHFR_1) 		4 LEU A 174
LYS A 177
GLU A 204
TYR A 205
 None
 1.06A 4z4gA-3dg8A:
undetectable		 4z4gA-3dg8A:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f0h AMINOTRANSFERASE

([Eubacterium]
rectale) 		PF00266
(Aminotran_5) 		4 LEU A 248
LYS A 252
GLU A  44
TYR A  45
 None
 1.04A 4z4gA-3f0hA:
undetectable		 4z4gA-3f0hA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdn SERINE/THREONINE-PRO
TEIN KINASE SGK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 230
TYR A 186
PRO A 374
GLU A 191
 None
 1.33A 4z4gA-3hdnA:
undetectable		 4z4gA-3hdnA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hs0 COBRA VENOM FACTOR

(Naja kaouthia) 		PF01835
(A2M_N)
PF07703
(A2M_N_2) 		4 LEU A 565
TYR A 563
LYS A 560
GLU A 203
 None
 1.09A 4z4gA-3hs0A:
undetectable		 4z4gA-3hs0A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4p CAPSID PROTEIN VP1

(Adeno-associated
virus) 		PF00740
(Parvo_coat) 		4 LEU A 352
TYR A 354
PRO A 353
TYR A 377
 None
 1.31A 4z4gA-3j4pA:
undetectable		 4z4gA-3j4pA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jr7 UNCHARACTERIZED EGV
FAMILY PROTEIN
COG1307

([Ruminococcus]
gnavus) 		PF02645
(DegV) 		4 LEU A 183
LYS A 206
PRO A 207
GLU A 181
 None
 0.82A 4z4gA-3jr7A:
undetectable		 4z4gA-3jr7A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jv3 INTERSECTIN-1

(Mus musculus) 		PF00621
(RhoGEF)
PF14604
(SH3_9) 		4 LEU A1249
PRO A1371
GLU A1242
TYR A1245
 None
 1.29A 4z4gA-3jv3A:
undetectable		 4z4gA-3jv3A:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kie CAPSID PROTEIN VP1

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		4 LEU A 350
TYR A 352
PRO A 351
TYR A 375
 None
 1.31A 4z4gA-3kieA:
undetectable		 4z4gA-3kieA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3knz PUTATIVE SUGAR
BINDING PROTEIN

(Salmonella
enterica) 		PF01380
(SIS) 		4 LEU A 215
PRO A 261
GLU A 309
TYR A 310
 None
 1.28A 4z4gA-3knzA:
4.2		 4z4gA-3knzA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4i HEAT SHOCK 70
(HSP70) PROTEIN

(Cryptosporidium
parvum) 		PF00012
(HSP70) 		4 LEU A  88
LYS A 116
PRO A 117
GLU A 133
 None
 1.14A 4z4gA-3l4iA:
7.4		 4z4gA-3l4iA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldo 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo sapiens) 		PF00012
(HSP70) 		4 LEU A  98
LYS A 125
PRO A 126
GLU A 143
 None
 1.14A 4z4gA-3ldoA:
6.4		 4z4gA-3ldoA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lzk FUMARYLACETOACETATE
HYDROLASE FAMILY
PROTEIN

(Sinorhizobium
meliloti) 		PF01557
(FAA_hydrolase) 		4 LEU A 173
LYS A 191
PRO A 192
GLU A 139
 None
CA  A 339 ( 3.9A)
None
CA  A 339 (-3.4A)
 1.26A 4z4gA-3lzkA:
undetectable		 4z4gA-3lzkA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntt CAPSID PROTEIN

(Adeno-associated
dependoparvovirus
B) 		PF00740
(Parvo_coat) 		4 LEU A 341
TYR A 343
PRO A 342
TYR A 366
 None
 1.32A 4z4gA-3nttA:
undetectable		 4z4gA-3nttA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ob8 BETA-GALACTOSIDASE

(Kluyveromyces
lactis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N) 		4 LEU A 549
TYR A 523
PRO A 524
TYR A 566
 None
 1.28A 4z4gA-3ob8A:
undetectable		 4z4gA-3ob8A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ra2 CAPSID PROTEIN

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		4 LEU A 353
TYR A 355
PRO A 354
TYR A 378
 None
 1.31A 4z4gA-3ra2A:
undetectable		 4z4gA-3ra2A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3shm CAPSID PROTEIN VP1

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		4 LEU A 351
TYR A 353
PRO A 352
TYR A 376
 None
 1.28A 4z4gA-3shmA:
undetectable		 4z4gA-3shmA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3stq PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		no annotation 4 LEU A  65
PRO A  66
GLU A  56
TYR A  55
 None
 1.26A 4z4gA-3stqA:
undetectable		 4z4gA-3stqA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ux1 CAPSID PROTEIN VP1

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		4 LEU A 352
TYR A 354
PRO A 353
TYR A 377
 None
 1.31A 4z4gA-3ux1A:
undetectable		 4z4gA-3ux1A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vx6 E1

(Kluyveromyces
marxianus) 		PF16420
(ATG7_N) 		4 TYR A 134
LYS A 269
PRO A 268
GLU A 259
 None
 1.11A 4z4gA-3vx6A:
undetectable		 4z4gA-3vx6A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wg6 CONJUGATED
POLYKETONE REDUCTASE
C1

(Candida
parapsilosis) 		PF00248
(Aldo_ket_red) 		4 LEU A 145
TYR A 104
PRO A 103
TYR A 122
 None
 1.04A 4z4gA-3wg6A:
undetectable		 4z4gA-3wg6A:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zvu ABSCISIC ACID
RECEPTOR PYR1

(Arabidopsis
thaliana) 		PF10604
(Polyketide_cyc2) 		4 LEU A 166
TYR A  58
LYS A  59
PRO A  60
 None
None
A8S  A 192 (-2.5A)
None
 1.03A 4z4gA-3zvuA:
2.4		 4z4gA-3zvuA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eq5 DNA LIGASE

(Thermococcus
sibiricus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 LEU A 405
PRO A 435
GLU A 398
TYR A 401
 None
 0.97A 4z4gA-4eq5A:
undetectable		 4z4gA-4eq5A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f5x RNA-DIRECTED RNA
POLYMERASE

(Rotavirus A) 		PF02123
(RdRP_4)
PF12289
(Rotavirus_VP1) 		4 LEU W 203
TYR W 202
PRO W 200
TYR W 234
 None
 1.30A 4z4gA-4f5xW:
undetectable		 4z4gA-4f5xW:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3

(Legionella
pneumophila) 		no annotation 4 LEU A 294
TYR A 378
LYS A 290
GLU A 535
 None
 1.17A 4z4gA-4fyeA:
2.3		 4z4gA-4fyeA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gyv FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 2

(Mus musculus) 		PF00621
(RhoGEF) 		4 LEU A 557
PRO A 684
GLU A 550
TYR A 553
 None
 1.19A 4z4gA-4gyvA:
undetectable		 4z4gA-4gyvA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h6y FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00169
(PH)
PF00621
(RhoGEF) 		4 LEU A 559
PRO A 685
GLU A 552
TYR A 555
 None
 1.25A 4z4gA-4h6yA:
undetectable		 4z4gA-4h6yA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i05 CATHEPSIN B-LIKE
PEPTIDASE (C01
FAMILY)

(Schistosoma
mansoni) 		PF00112
(Peptidase_C1) 		4 TYR A 186
LYS A 177
PRO A 176
GLU A 165
 None
 1.09A 4z4gA-4i05A:
undetectable		 4z4gA-4i05A:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iov CAPSID PROTEIN VP1

(Adeno-associated
virus) 		PF00740
(Parvo_coat) 		4 LEU A 341
TYR A 343
PRO A 342
TYR A 366
 None
 1.33A 4z4gA-4iovA:
undetectable		 4z4gA-4iovA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ka8 OLIGOPEPTIDASE A

(Arabidopsis
thaliana) 		PF01432
(Peptidase_M3) 		4 LEU A 361
TYR A 374
LYS A 365
GLU A 250
 None
 1.32A 4z4gA-4ka8A:
2.9		 4z4gA-4ka8A:
23.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4krf PROTEIN ARGONAUTE-1

(Homo sapiens) 		PF02170
(PAZ)
PF02171
(Piwi)
PF08699
(ArgoL1)
PF16486
(ArgoN)
PF16487
(ArgoMid)
PF16488
(ArgoL2) 		4 LEU A 648
TYR A 652
PRO A 659
TYR A 696
 None
 0.33A 4z4gA-4krfA:
59.7		 4z4gA-4krfA:
82.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lcc BETA-2-MICROGLOBULIN
, MHC CLASS
I-RELATED PROTEIN

(Bos taurus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 LEU C  64
TYR C  28
PRO C 345
TYR C  10
 None
 0.90A 4z4gA-4lccC:
undetectable		 4z4gA-4lccC:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0m PUTATIVE
UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 4 LEU A 199
TYR A 231
LYS A 229
GLU A 196
 None
 1.20A 4z4gA-4m0mA:
3.0		 4z4gA-4m0mA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pmn TAT-SECRETED PROTEIN
RV2525C

(Mycobacterium
tuberculosis) 		PF08924
(DUF1906) 		4 LEU A 127
TYR A  65
LYS A  79
PRO A  80
 GOL  A 302 (-4.9A)
None
MES  A 301 (-2.7A)
None
 1.01A 4z4gA-4pmnA:
3.0		 4z4gA-4pmnA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pmr TAT-SECRETED PROTEIN
RV2525C

(Mycobacterium
tuberculosis) 		PF08924
(DUF1906) 		4 LEU A 127
TYR A  65
LYS A  79
PRO A  80
 None
None
EPE  A 301 (-2.8A)
None
 1.01A 4z4gA-4pmrA:
2.3		 4z4gA-4pmrA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rso CAPSID PROTEIN VP1

(Non-human
primate
Adeno-associated
virus) 		PF00740
(Parvo_coat) 		4 LEU A 352
TYR A 354
PRO A 353
TYR A 377
 None
 1.29A 4z4gA-4rsoA:
undetectable		 4z4gA-4rsoA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT
METHANOL
DEHYDROGENASE, SMALL
SUBUNIT

(Methylococcus
capsulatus;
Methylococcus
capsulatus) 		no annotation
PF02315
(MDH) 		4 TYR I  23
LYS I  38
PRO I  39
GLU B 295
 None
 1.24A 4z4gA-4tqoI:
undetectable		 4z4gA-4tqoI:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u8h CRYPTOCHROME-2

(Mus musculus) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		4 LEU A 290
TYR A 291
LYS A 295
GLU A 253
 None
 1.09A 4z4gA-4u8hA:
3.0		 4z4gA-4u8hA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wft TRNA-DIHYDROURIDINE(
20) SYNTHASE
[NAD(P)+]-LIKE

(Homo sapiens) 		no annotation 4 LEU C 374
PRO C 386
GLU C 423
TYR C 388
 None
 1.28A 4z4gA-4wftC:
undetectable		 4z4gA-4wftC:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xdy KETOL-ACID
REDUCTOISOMERASE

(uncultured
archaeon
GZfos26G2) 		PF01450
(IlvC)
PF07991
(IlvN) 		4 LEU A 102
PRO A 124
GLU A  95
TYR A  94
 None
 0.98A 4z4gA-4xdyA:
undetectable		 4z4gA-4xdyA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y1p 3-ISOPROPYLMALATE
DEHYDROGENASE

(Sulfolobus
acidocaldarius) 		PF00180
(Iso_dh) 		4 LEU A 315
TYR A 314
LYS A 313
GLU A 311
 None
 1.27A 4z4gA-4y1pA:
2.3		 4z4gA-4y1pA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a4j FORMATE--TETRAHYDROF
OLATE LIGASE

(Tepidanaerobacter
acetatoxydans) 		PF01268
(FTHFS) 		4 TYR A  44
LYS A 255
PRO A 256
GLU A  33
 EDO  A1562 (-4.5A)
EDO  A1562 (-3.2A)
None
None
 0.79A 4z4gA-5a4jA:
3.9		 4z4gA-5a4jA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b16 RIBONUCLEASE
3,DROSHA,RIBONUCLEAS
E
3,DROSHA,RIBONUCLEAS
E 3

(Homo sapiens) 		PF00035
(dsrm)
PF00636
(Ribonuclease_3)
PF14622
(Ribonucleas_3_3) 		4 LEU A1265
PRO A1282
GLU A1321
TYR A1284
 None
 1.22A 4z4gA-5b16A:
undetectable		 4z4gA-5b16A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e3c DIPEPTIDYL PEPTIDASE
3

(Homo sapiens) 		PF03571
(Peptidase_M49) 		4 LEU A  93
PRO A  72
GLU A  86
TYR A  89
 None
 1.23A 4z4gA-5e3cA:
undetectable		 4z4gA-5e3cA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw8 HYPOTHETICAL
SECRETORY LIPASE
(FAMILY 3)

(Malassezia
globosa) 		PF01764
(Lipase_3) 		4 LEU A 200
TYR A 246
PRO A 231
GLU A 264
 None
 1.32A 4z4gA-5gw8A:
undetectable		 4z4gA-5gw8A:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hws 2-DEHYDROPANTOATE
2-REDUCTASE

(Thermococcus
kodakarensis) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		4 LEU A 102
TYR A 265
GLU A 272
TYR A 273
 None
 1.21A 4z4gA-5hwsA:
2.1		 4z4gA-5hwsA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikz OXALATE BIOSYNTHETIC
COMPONENT 1

(Burkholderia
thailandensis) 		PF05853
(BKACE) 		4 LEU A 729
LYS A 680
PRO A 681
GLU A 688
 None
 0.65A 4z4gA-5ikzA:
2.7		 4z4gA-5ikzA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6q CELL WALL BINDING
PROTEIN CWP8

(Clostridioides
difficile) 		PF04122
(CW_binding_2) 		4 LEU A 223
TYR A 221
LYS A 216
GLU A 261
 None
 0.90A 4z4gA-5j6qA:
5.0		 4z4gA-5j6qA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o33 KALIRIN

(Rattus
norvegicus) 		PF00621
(RhoGEF) 		4 LEU B1252
PRO B1366
GLU B1245
TYR B1248
 None
None
None
EDO  B1502 ( 4.5A)
 1.26A 4z4gA-5o33B:
undetectable		 4z4gA-5o33B:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ocr KAPPA-CARRAGEENASE

(Zobellia
galactanivorans) 		no annotation 4 LEU A 185
TYR A 249
LYS A 248
GLU A 206
 None
 1.19A 4z4gA-5ocrA:
undetectable		 4z4gA-5ocrA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5suo EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF12010
(DUF3502) 		4 LEU A 251
PRO A 210
GLU A 183
TYR A 182
 None
 1.27A 4z4gA-5suoA:
undetectable		 4z4gA-5suoA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5twb FERREDOXIN--NADP
REDUCTASE

(Staphylococcus
aureus) 		PF07992
(Pyr_redox_2) 		4 LEU A  71
TYR A  72
LYS A  74
PRO A  75
 None
 1.01A 4z4gA-5twbA:
undetectable		 4z4gA-5twbA:
19.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vm9 PROTEIN ARGONAUTE-3

(Homo sapiens) 		no annotation 6 LEU A 651
TYR A 655
LYS A 661
PRO A 662
GLU A 696
TYR A 699
 None
 0.74A 4z4gA-5vm9A:
55.6		 4z4gA-5vm9A:
79.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wea PROTEIN ARGONAUTE-2

(Homo sapiens) 		no annotation 5 LEU A 650
LYS A 660
PRO A 661
GLU A 695
TYR A 698
 IPH  A 901 (-4.7A)
None
None
IPH  A 901 (-3.6A)
IPH  A 901 ( 4.9A)
 0.92A 4z4gA-5weaA:
58.7		 4z4gA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wea PROTEIN ARGONAUTE-2

(Homo sapiens) 		no annotation 5 LEU A 650
TYR A 654
PRO A 661
GLU A 695
TYR A 698
 IPH  A 901 (-4.7A)
None
None
IPH  A 901 (-3.6A)
IPH  A 901 ( 4.9A)
 0.56A 4z4gA-5weaA:
58.7		 4z4gA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x62 CARNOSINE
N-METHYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF07942
(N2227) 		4 LEU A 368
TYR A 385
PRO A 383
GLU A 120
 None
 1.00A 4z4gA-5x62A:
undetectable		 4z4gA-5x62A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xm3 GLUCOSE
DEHYDROGENASE
METHANOL
DEHYDROGENASE
[CYTOCHROME C]
SUBUNIT 2

(Methylophaga
aminisulfidivorans;
Methylophaga
aminisulfidivorans) 		no annotation
no annotation 		4 TYR B  25
LYS B  40
PRO B  41
GLU A 298
 None
 1.23A 4z4gA-5xm3B:
undetectable		 4z4gA-5xm3B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yh0 DRFAM20C1

(Danio rerio) 		no annotation 4 LEU A 246
LYS A 261
PRO A 262
GLU A 282
 None
 1.17A 4z4gA-5yh0A:
undetectable		 4z4gA-5yh0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zib -

(-) 		no annotation 4 LEU A 581
LYS A 538
PRO A 537
GLU A 586
 None
 1.22A 4z4gA-5zibA:
2.5		 4z4gA-5zibA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6u GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
BETA-2,GAMMA-AMINOBU
TYRIC ACID RECEPTOR
SUBUNIT BETA-2
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
GAMMA-2,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT GAMMA-2

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		4 LEU A 272
TYR E 292
GLU A  52
TYR A 143
 None
 1.22A 4z4gA-6d6uA:
undetectable		 4z4gA-6d6uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoe 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Cricetulus
griseus) 		no annotation 4 LEU A  98
LYS A 125
PRO A 126
GLU A 143
 None
 1.28A 4z4gA-6eoeA:
2.7		 4z4gA-6eoeA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fgk GTP
PYROPHOSPHOKINASE
YWAC

(Bacillus
subtilis) 		no annotation 4 LEU A 134
TYR A 122
LYS A 120
GLU A 154
 None
 0.83A 4z4gA-6fgkA:
undetectable		 4z4gA-6fgkA:
undetectable