SIMILAR PATTERNS OF AMINO ACIDS FOR 4Z4G_A_IPHA902

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bt0 PROTEIN
(UBIQUITIN-LIKE
PROTEIN 7, RUB1)

(Arabidopsis
thaliana) 		PF00240
(ubiquitin) 		4 ILE A  44
GLN A  49
ILE A  23
ASP A  52
 None
 0.83A 4z4gA-1bt0A:
0.0		 4z4gA-1bt0A:
7.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dtd METALLOCARBOXYPEPTID
ASE INHIBITOR

(Hirudo
medicinalis) 		no annotation 4 ARG B  59
GLN B  57
ILE B  21
ASP B   6
 None
 1.05A 4z4gA-1dtdB:
0.1		 4z4gA-1dtdB:
5.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ei6 PHOSPHONOACETATE
HYDROLASE

(Pseudomonas
fluorescens) 		PF01663
(Phosphodiest) 		4 ARG A 335
ILE A 336
PRO A  77
ILE A  82
 None
 0.97A 4z4gA-1ei6A:
2.0		 4z4gA-1ei6A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0z THIS PROTEIN

(Escherichia
coli) 		PF02597
(ThiS) 		4 ILE A  40
GLN A  39
ILE A  57
ASP A  55
 None
 1.02A 4z4gA-1f0zA:
undetectable		 4z4gA-1f0zA:
6.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1geg ACETOIN REDUCTASE

(Klebsiella
pneumoniae) 		PF00106
(adh_short) 		4 ILE A 184
GLN A 140
PRO A 182
ILE A 249
 None
BME  A1462 (-3.9A)
NAD  A2001 ( 3.7A)
None
 1.06A 4z4gA-1gegA:
3.4		 4z4gA-1gegA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k1x 4-ALPHA-GLUCANOTRANS
FERASE

(Thermococcus
litoralis) 		PF03065
(Glyco_hydro_57)
PF09094
(DUF1925)
PF09095
(DUF1926) 		4 ARG A  98
ILE A 102
PRO A  88
ILE A  93
 None
 1.08A 4z4gA-1k1xA:
0.6		 4z4gA-1k1xA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mpx ALPHA-AMINO ACID
ESTER HYDROLASE

(Xanthomonas
citri) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		4 GLN A 303
PRO A 199
ILE A 201
ASP A 207
 None
 1.01A 4z4gA-1mpxA:
3.7		 4z4gA-1mpxA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qwj CYTIDINE
MONOPHOSPHO-N-ACETYL
NEURAMINIC ACID
SYNTHETASE

(Mus musculus) 		PF02348
(CTP_transf_3) 		4 ILE A  70
PRO A 145
ILE A 246
ASP A 245
 None
None
None
NCC  A2002 ( 4.9A)
 0.89A 4z4gA-1qwjA:
0.0		 4z4gA-1qwjA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s4o GLYCOLIPID
2-ALPHA-MANNOSYLTRAN
SFERASE

(Saccharomyces
cerevisiae) 		PF01793
(Glyco_transf_15) 		4 CSS A 406
GLN A 410
PRO A 395
ASP A 397
 None
 0.88A 4z4gA-1s4oA:
0.0		 4z4gA-1s4oA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sif UBIQUITIN

(Homo sapiens) 		PF00240
(ubiquitin) 		4 ILE A  44
GLN A  49
ILE A  23
ASP A  52
 None
 0.64A 4z4gA-1sifA:
0.0		 4z4gA-1sifA:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1woc PRIMOSOMAL
REPLICATION PROTEIN
N

(Escherichia
coli) 		PF00436
(SSB) 		5 CYH A  27
ILE A  53
GLN A  28
PRO A  15
ILE A  66
 None
 1.45A 4z4gA-1wocA:
undetectable		 4z4gA-1wocA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xpj HYPOTHETICAL PROTEIN

(Vibrio cholerae) 		PF08282
(Hydrolase_3) 		4 ARG A  49
ILE A  61
PRO A  67
ILE A  68
 None
 0.94A 4z4gA-1xpjA:
3.1		 4z4gA-1xpjA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z2o INOSITOL
1,3,4-TRISPHOSPHATE
5/6-KINASE

(Entamoeba
histolytica) 		PF05770
(Ins134_P3_kin) 		4 ILE X 241
GLN X 190
ILE X 177
ASP X 275
 None
None
ADP  X 871 (-4.6A)
MG  X1295 (-3.2A)
 1.04A 4z4gA-1z2oX:
3.6		 4z4gA-1z2oX:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ztm FUSION GLYCOPROTEIN

(Human
respirovirus 3) 		PF00523
(Fusion_gly) 		4 CSS A 340
ILE A  40
PRO A 344
ILE A 293
 None
 0.98A 4z4gA-1ztmA:
undetectable		 4z4gA-1ztmA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fmt METHIONYL-TRNA FMET
FORMYLTRANSFERASE

(Escherichia
coli) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		4 CYH A 106
ILE A 107
PRO A 102
ILE A   7
 None
 1.03A 4z4gA-2fmtA:
2.5		 4z4gA-2fmtA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h1k PANCREATIC AND
DUODENAL HOMEOBOX 1

(Mesocricetus
auratus) 		PF00046
(Homeobox) 		4 ARG A  31
ILE A  47
GLN A  50
ILE A  26
 None
 0.98A 4z4gA-2h1kA:
undetectable		 4z4gA-2h1kA:
5.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iln BOWMAN-BIRK TYPE
PROTEINASE INHIBITOR

(Medicago
scutellata) 		PF00228
(Bowman-Birk_leg) 		4 CSS I  22
ILE I  53
GLN I  21
PRO I  20
 None
 0.94A 4z4gA-2ilnI:
undetectable		 4z4gA-2ilnI:
5.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ljs TRYPSIN INHIBITOR 3

(Momordica
cochinchinensis) 		PF00299
(Squash) 		4 CSS A  21
ILE A  22
PRO A   5
ILE A   7
 None
PCA  A   1 ( 4.9A)
None
None
 0.96A 4z4gA-2ljsA:
undetectable		 4z4gA-2ljsA:
3.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ln7 LPXTG-SITE
TRANSPEPTIDASE
FAMILY PROTEIN

(Bacillus
anthracis) 		PF04203
(Sortase) 		4 ARG A 134
ILE A 100
PRO A 132
ASP A 130
 None
 1.04A 4z4gA-2ln7A:
undetectable		 4z4gA-2ln7A:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vkw NEURAL CELL ADHESION
MOLECULE 1,140 KDA
ISOFORM

(Homo sapiens) 		PF00041
(fn3) 		4 ILE A 622
GLN A 624
PRO A 604
ILE A 631
 None
 1.04A 4z4gA-2vkwA:
undetectable		 4z4gA-2vkwA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3a PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT BETA ISOFORM

(Mus musculus) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B) 		4 ARG A 694
ILE A 154
ILE A 120
ASP A 117
 None
 0.96A 4z4gA-2y3aA:
undetectable		 4z4gA-2y3aA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai5 YEAST ENHANCED GREEN
FLUORESCENT
PROTEIN,UBIQUITIN

(Aequorea
victoria;
Mus musculus) 		PF00240
(ubiquitin)
PF01353
(GFP) 		4 ILE A 276
GLN A 281
ILE A 255
ASP A 284
 None
 0.84A 4z4gA-3ai5A:
undetectable		 4z4gA-3ai5A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8l UNCHARACTERIZED
PROTEIN

(Novosphingobium
aromaticivorans) 		PF13577
(SnoaL_4) 		4 ARG A   8
ILE A  11
PRO A   4
ILE A   5
 None
 1.00A 4z4gA-3b8lA:
undetectable		 4z4gA-3b8lA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3byq UNCHARACTERIZED
PROTEIN DUF1185

(Bordetella
bronchiseptica) 		PF06684
(AA_synth) 		4 ILE A  37
PRO A 156
ILE A 152
ASP A 154
 None
 1.02A 4z4gA-3byqA:
2.1		 4z4gA-3byqA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwg SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 3

(Mus musculus) 		PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind) 		4 CYH A 251
ILE A 252
GLN A 248
ILE A 258
 None
 1.05A 4z4gA-3cwgA:
undetectable		 4z4gA-3cwgA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1j GLYCOGEN SYNTHASE

(Escherichia
coli) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		4 ARG A  38
GLN A   2
PRO A 130
ASP A 125
 None
 1.04A 4z4gA-3d1jA:
3.3		 4z4gA-3d1jA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d5n Q97W15_SULSO

(Sulfolobus
solfataricus) 		PF12804
(NTP_transf_3) 		4 ILE A  31
PRO A  98
ILE A 175
ASP A 174
 None
 1.05A 4z4gA-3d5nA:
undetectable		 4z4gA-3d5nA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3x BIPA

(Vibrio
parahaemolyticus) 		PF00679
(EFG_C) 		4 ARG A 146
ILE A 143
PRO A 168
ILE A 204
 None
None
MLY  A 147 ( 4.7A)
MLY  A 147 ( 4.5A)
 1.07A 4z4gA-3e3xA:
undetectable		 4z4gA-3e3xA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9o UBIQUITIN

(Homo sapiens) 		PF00240
(ubiquitin) 		4 ILE B  44
GLN B  49
ILE B  23
ASP B  52
 None
 0.78A 4z4gA-3k9oB:
undetectable		 4z4gA-3k9oB:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l0w MONOUBIQUITINATED
PROLIFERATING CELL
NUCLEAR ANTIGEN

(Saccharomyces
cerevisiae) 		PF00240
(ubiquitin)
PF02747
(PCNA_C) 		4 ILE B  44
GLN B  49
ILE B  23
ASP B  52
 None
 0.65A 4z4gA-3l0wB:
undetectable		 4z4gA-3l0wB:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwr A RUBISCO-LIKE
PROTEIN

(Paraburkholderia
fungorum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 ARG A 399
PRO A 162
ILE A 164
ASP A 192
 SO4  A 434 (-3.1A)
None
None
SO4  A 434 ( 4.8A)
 0.93A 4z4gA-3nwrA:
2.1		 4z4gA-3nwrA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ong UBIQUITIN-ACTIVATING
ENZYME E1-LIKE

(Saccharomyces
cerevisiae) 		no annotation 4 CYH A 442
ILE A 525
PRO A 548
ILE A 550
 None
 0.99A 4z4gA-3ongA:
undetectable		 4z4gA-3ongA:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3f RIBONUCLEASE/UBIQUIT
IN CHIMERIC PROTEIN

(Bacillus
amyloliquefaciens;
Homo sapiens) 		PF00240
(ubiquitin)
PF00545
(Ribonuclease) 		4 ILE A 148
GLN A 153
ILE A 127
ASP A 156
 None
SO4  A 191 ( 3.2A)
None
None
 0.73A 4z4gA-3q3fA:
undetectable		 4z4gA-3q3fA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r8x METHIONYL-TRNA
FORMYLTRANSFERASE

(Yersinia pestis) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		4 CYH A 107
ILE A 108
PRO A 103
ILE A   8
 None
 1.06A 4z4gA-3r8xA:
3.4		 4z4gA-3r8xA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ru4 BOWMAN-BIRK TYPE
SEED TRYPSIN AND
CHYMOTRYPSIN
INHIBITOR

(Vigna
unguiculata) 		PF00228
(Bowman-Birk_leg) 		4 CSS B  32
ILE B  64
GLN B  31
PRO B  30
 None
 1.02A 4z4gA-3ru4B:
undetectable		 4z4gA-3ru4B:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t02 PHOSPHONOACETATE
HYDROLASE

(Sinorhizobium
meliloti) 		PF01663
(Phosphodiest) 		4 ARG A 344
ILE A 345
PRO A  81
ILE A  86
 None
 1.04A 4z4gA-3t02A:
undetectable		 4z4gA-3t02A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t1i DOUBLE-STRAND BREAK
REPAIR PROTEIN
MRE11A

(Homo sapiens) 		PF00149
(Metallophos)
PF04152
(Mre11_DNA_bind) 		4 ILE A 263
GLN A 265
PRO A 266
ASP A  20
 None
None
None
MN  A 412 (-3.1A)
 0.84A 4z4gA-3t1iA:
3.3		 4z4gA-3t1iA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8q MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Hoeflea
phototrophica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 CYH A 282
GLN A 256
PRO A 257
ASP A 258
 None
 0.91A 4z4gA-3t8qA:
2.6		 4z4gA-3t8qA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8q MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Hoeflea
phototrophica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 CYH A 282
ILE A 254
GLN A 256
PRO A 257
 None
 1.03A 4z4gA-3t8qA:
2.6		 4z4gA-3t8qA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tgw V-TYPE ATP SYNTHASE
BETA CHAIN

(Methanosarcina
mazei) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		4 ILE A 321
PRO A 301
ILE A 249
ASP A 248
 None
 1.02A 4z4gA-3tgwA:
undetectable		 4z4gA-3tgwA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7v BETA-GALACTOSIDASE

(Caulobacter
vibrioides) 		PF02449
(Glyco_hydro_42) 		4 GLN A 218
PRO A 215
ILE A 153
ASP A 212
 None
 1.07A 4z4gA-3u7vA:
2.7		 4z4gA-3u7vA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v47 FLAGELLIN

(Salmonella
enterica) 		PF00669
(Flagellin_N)
PF00700
(Flagellin_C) 		4 ILE C 115
GLN C 116
ILE C 122
ASP C 123
 None
 1.03A 4z4gA-3v47C:
undetectable		 4z4gA-3v47C:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vdz UBIQUITIN-40S
RIBOSOMAL PROTEIN
S27A

(Homo sapiens;
synthetic
construct) 		PF00240
(ubiquitin) 		4 ILE A 144
GLN A 149
ILE A 123
ASP A 152
 None
None
None
SO4  A 204 (-3.5A)
 0.93A 4z4gA-3vdzA:
undetectable		 4z4gA-3vdzA:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wl4 UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		PF02585
(PIG-L) 		4 ILE A 223
GLN A 218
ILE A  46
ASP A  43
 HEZ  A 315 ( 4.3A)
TAM  A 309 ( 4.0A)
TAM  A 309 (-4.9A)
CD  A 301 ( 2.1A)
 0.95A 4z4gA-3wl4A:
2.3		 4z4gA-3wl4A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a35 MITOCHONDRIAL
ENOLASE SUPERFAMILY
MEMBER 1

(Homo sapiens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A 316
GLN A 319
ILE A 159
ASP A 161
 None
 0.99A 4z4gA-4a35A:
2.1		 4z4gA-4a35A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ast ALDO-KETO REDUCTASE
AKR14A1

(Escherichia
coli) 		PF00248
(Aldo_ket_red) 		4 CYH A 219
ILE A 191
GLN A 193
PRO A 194
 None
 1.06A 4z4gA-4astA:
2.7		 4z4gA-4astA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4au0 EXOGLUCANASE 2

(Trichoderma
reesei) 		PF01341
(Glyco_hydro_6) 		4 CYH A 245
ILE A 246
PRO A 172
ILE A 187
 None
 0.98A 4z4gA-4au0A:
undetectable		 4z4gA-4au0A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwe GLYPICAN-1

(Homo sapiens) 		PF01153
(Glypican) 		4 CSS A  32
GLN A  51
PRO A  50
ILE A  54
 None
 1.03A 4z4gA-4bweA:
undetectable		 4z4gA-4bweA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4da5 CHOLINE KINASE ALPHA

(Homo sapiens) 		PF01633
(Choline_kinase) 		4 ARG A 213
GLN A 308
ILE A 329
ASP A 330
 None
0H7  A 502 (-3.1A)
None
None
 1.08A 4z4gA-4da5A:
undetectable		 4z4gA-4da5A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hfq MUTT/NUDIX FAMILY
PROTEIN

(Streptococcus
pneumoniae) 		PF00293
(NUDIX)
PF12535
(Nudix_N) 		4 CYH A  83
ILE A  82
PRO A  96
ILE A 114
 None
None
SO4  A 304 ( 4.9A)
None
 0.99A 4z4gA-4hfqA:
undetectable		 4z4gA-4hfqA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i5u CHIMERIC CEL6A

(Humicola
insolens;
Trichoderma
reesei;
Chaetomium
thermophilum) 		PF01341
(Glyco_hydro_6) 		4 CYH A 246
ILE A 247
PRO A 173
ILE A 188
 ACT  A 502 ( 3.9A)
None
None
None
 0.99A 4z4gA-4i5uA:
undetectable		 4z4gA-4i5uA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ig9 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1

(Homo sapiens) 		PF02146
(SIR2) 		4 CYH A 362
GLN A 345
PRO A 447
ILE A 451
 None
 0.99A 4z4gA-4ig9A:
2.5		 4z4gA-4ig9A:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ii2 UBIQUITIN-60S
RIBOSOMAL PROTEIN
L40

(Schizosaccharomyces
pombe) 		PF00240
(ubiquitin) 		4 ILE B  44
GLN B  49
ILE B  23
ASP B  52
 None
EDO  B 101 (-2.8A)
None
None
 0.76A 4z4gA-4ii2B:
undetectable		 4z4gA-4ii2B:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ii3 UBIQUITIN-60S
RIBOSOMAL PROTEIN
L40

(Schizosaccharomyces
pombe) 		PF00240
(ubiquitin) 		4 ILE B  44
GLN B  49
ILE B  23
ASP B  52
 None
 0.75A 4z4gA-4ii3B:
undetectable		 4z4gA-4ii3B:
8.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4isb LONG CHAIN FATTY
ACID COA LIGASE
FADD10

(Mycobacterium
tuberculosis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 ILE A 361
PRO A 363
ILE A 400
ASP A 401
 None
 1.08A 4z4gA-4isbA:
3.8		 4z4gA-4isbA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpu ELECTRON TRANSFER
FLAVOPROTEIN ALPHA
SUBUNIT
ELECTRON TRANSFER
FLAVOPROTEIN
ALPHA/BETA-SUBUNIT

(Acidaminococcus
fermentans;
Acidaminococcus
fermentans) 		PF00766
(ETF_alpha)
PF01012
(ETF)
PF01012
(ETF) 		4 ARG A 204
CYH A 202
ILE A 203
ASP B 159
 None
 0.99A 4z4gA-4kpuA:
2.5		 4z4gA-4kpuA:
17.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4krf PROTEIN ARGONAUTE-1

(Homo sapiens) 		PF02170
(PAZ)
PF02171
(Piwi)
PF08699
(ArgoL1)
PF16486
(ArgoN)
PF16487
(ArgoMid)
PF16488
(ArgoL2) 		7 ARG A 686
CYH A 689
ILE A 690
GLN A 697
PRO A 698
ILE A 700
ASP A 769
 None
 0.23A 4z4gA-4krfA:
59.7		 4z4gA-4krfA:
82.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9d ADENYLOSUCCINATE
SYNTHETASE

(Bacillus
anthracis) 		PF00709
(Adenylsucc_synt) 		4 ILE A 132
GLN A 223
ILE A 229
ASP A 228
 AMP  A 501 ( 4.3A)
AMP  A 501 (-4.1A)
None
None
 0.97A 4z4gA-4m9dA:
undetectable		 4z4gA-4m9dA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pqq MUSKELIN

(Mus musculus) 		PF06588
(Muskelin_N) 		4 CYH A 164
GLN A 162
ILE A 160
ASP A 157
 None
 1.00A 4z4gA-4pqqA:
undetectable		 4z4gA-4pqqA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tx7 CLASS I CHITINASE

(Vigna
unguiculata) 		PF00182
(Glyco_hydro_19) 		4 ILE A 163
PRO A 184
ILE A 181
ASP A 179
 None
 1.00A 4z4gA-4tx7A:
undetectable		 4z4gA-4tx7A:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4um2 TELOMERASE-BINDING
PROTEIN EST1A

(Homo sapiens) 		PF10373
(EST1_DNA_bind)
PF10374
(EST1) 		4 ARG A 727
CYH A 728
ILE A 730
GLN A 726
 None
 1.03A 4z4gA-4um2A:
undetectable		 4z4gA-4um2A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4whb PHENYLUREA HYDROLASE
B

(Mycolicibacterium
brisbanense) 		no annotation 4 ARG E 136
ILE E 137
ILE E 407
ASP E 417
 None
 0.99A 4z4gA-4whbE:
undetectable		 4z4gA-4whbE:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zg7 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2

(Homo sapiens) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		4 ARG A 440
ILE A 441
PRO A 223
ILE A 228
 GOL  A 912 (-3.5A)
None
None
None
 0.91A 4z4gA-4zg7A:
undetectable		 4z4gA-4zg7A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zzh NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1

(Homo sapiens) 		PF02146
(SIR2) 		4 CYH A 362
GLN A 345
PRO A 447
ILE A 451
 None
 1.01A 4z4gA-4zzhA:
2.2		 4z4gA-4zzhA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b83 TETRA UBIQUITIN

(Homo sapiens) 		PF00240
(ubiquitin) 		4 ILE A 120
GLN A 125
ILE A  99
ASP A 128
 None
 0.76A 4z4gA-5b83A:
undetectable		 4z4gA-5b83A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b83 TETRA UBIQUITIN

(Homo sapiens) 		PF00240
(ubiquitin) 		4 ILE A 196
GLN A 201
ILE A 175
ASP A 204
 None
 0.71A 4z4gA-5b83A:
undetectable		 4z4gA-5b83A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b83 TETRA UBIQUITIN

(Homo sapiens) 		PF00240
(ubiquitin) 		4 ILE A 272
GLN A 277
ILE A 251
ASP A 280
 None
 0.68A 4z4gA-5b83A:
undetectable		 4z4gA-5b83A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9a RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza C
virus) 		PF00602
(Flu_PB1) 		4 CYH B 169
ILE B 173
PRO B 252
ILE B 256
 None
 0.99A 4z4gA-5d9aB:
undetectable		 4z4gA-5d9aB:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dtu PRP28

(Chaetomium
thermophilum) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 ARG A 304
ILE A 307
GLN A 303
ILE A 264
 None
None
ADP  A 801 (-2.8A)
None
 0.97A 4z4gA-5dtuA:
undetectable		 4z4gA-5dtuA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f0o COHESIN SUBUNIT
PDS5,
KLTH0D07062P,KLTH0D0
7062P,KLTH0D07062P,C
OHESIN SUBUNIT PDS5,
KLTH0D07062P,KLTH0D0
7062P,KLTH0D07062P,C
OHESIN SUBUNIT PDS5,
KLTH0D07062P,KLTH0D0
7062P,KLTH0D07062P,C
OHESIN SUBUNIT PDS5,
KLTH0D07062P,KLTH0D0
7062P

(Lachancea
thermotolerans) 		no annotation 4 ARG A 450
ILE A 454
ILE A 494
ASP A 496
 None
 1.08A 4z4gA-5f0oA:
undetectable		 4z4gA-5f0oA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gju ATP-DEPENDENT RNA
HELICASE DEAD

(Escherichia
coli) 		PF00270
(DEAD) 		4 CYH A  36
ILE A  37
GLN A  33
ILE A 210
 None
None
AMP  A 301 (-2.4A)
None
 0.96A 4z4gA-5gjuA:
2.1		 4z4gA-5gjuA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h07 POLYUBIQUITIN-C

(Homo sapiens) 		PF00240
(ubiquitin) 		4 ILE A  44
GLN A  49
ILE A  23
ASP A  52
 None
 1.02A 4z4gA-5h07A:
undetectable		 4z4gA-5h07A:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h07 POLYUBIQUITIN-C

(Homo sapiens) 		PF00240
(ubiquitin) 		4 ILE A 144
GLN A 149
ILE A 123
ASP A 152
 None
 0.89A 4z4gA-5h07A:
undetectable		 4z4gA-5h07A:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h07 POLYUBIQUITIN-C

(Homo sapiens) 		PF00240
(ubiquitin) 		4 ILE A 244
GLN A 249
ILE A 223
ASP A 252
 None
 0.90A 4z4gA-5h07A:
undetectable		 4z4gA-5h07A:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5c MITOCHONDRIAL
DISTRIBUTION AND
MORPHOLOGY PROTEIN
12

(Kluyveromyces
lactis) 		no annotation 4 ARG A  11
ILE A  10
PRO A  51
ASP A  99
 None
 0.96A 4z4gA-5h5cA:
undetectable		 4z4gA-5h5cA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hpt UBIQUITIN VARIANT
P2.3

(Homo sapiens) 		PF00240
(ubiquitin) 		4 ILE B  44
GLN B  49
ILE B  23
ASP B  52
 None
 0.73A 4z4gA-5hptB:
undetectable		 4z4gA-5hptB:
6.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hvn 3-DEHYDROQUINATE
SYNTHASE

(Francisella
tularensis) 		PF01761
(DHQ_synthase) 		4 ARG A 176
ILE A 179
GLN A 175
PRO A 174
 None
 1.03A 4z4gA-5hvnA:
undetectable		 4z4gA-5hvnA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijg CYS/MET METABOLISM
PYRIDOXAL-PHOSPHATE-
DEPENDENT ENZYME

(Brucella
melitensis) 		PF01053
(Cys_Met_Meta_PP) 		4 ARG A 197
PRO A 211
ILE A 213
ASP A 233
 None
 0.81A 4z4gA-5ijgA:
2.9		 4z4gA-5ijgA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbo BETA-GLUCOSIDASE

(Trichoderma
harzianum) 		PF00232
(Glyco_hydro_1) 		4 ILE A 102
GLN A 103
ILE A 109
ASP A 110
 None
 1.04A 4z4gA-5jboA:
undetectable		 4z4gA-5jboA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III

(Methanococcoides
burtonii) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 ARG A 389
ILE A 382
ILE A 362
ASP A 366
 None
None
None
MG  A 503 (-2.2A)
 1.00A 4z4gA-5macA:
undetectable		 4z4gA-5macA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nsj PRE-GLYCOPROTEIN
POLYPROTEIN GP
COMPLEX

(Whitewater
Arroyo
mammarenavirus) 		no annotation 4 ILE A 162
GLN A 160
PRO A 159
ILE A 177
 None
 1.07A 4z4gA-5nsjA:
undetectable		 4z4gA-5nsjA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o76 UBV.PCBL UBIQUITIN
VARIANT

(Homo sapiens) 		no annotation 4 ILE E  44
GLN E  49
ILE E  23
ASP E  52
 None
 0.70A 4z4gA-5o76E:
undetectable		 4z4gA-5o76E:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ucl POLYUBIQUITIN-B

(Homo sapiens) 		PF00240
(ubiquitin) 		4 ILE A  44
GLN A  49
ILE A  23
ASP A  52
 None
 0.91A 4z4gA-5uclA:
undetectable		 4z4gA-5uclA:
7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uju NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans) 		PF00171
(Aldedh) 		4 ILE A 452
GLN A 347
PRO A 346
ILE A 349
 None
 1.07A 4z4gA-5ujuA:
5.5		 4z4gA-5ujuA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1

(Schizosaccharomyces
pombe) 		PF00899
(ThiF)
PF09358
(E1_UFD)
PF10585
(UBA_e1_thiolCys)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		4 ILE A 901
PRO A 904
ILE A 916
ASP A 914
 None
 0.89A 4z4gA-5um6A:
4.1		 4z4gA-5um6A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v5g UBIQUITIN VARIANT
CC.4

(synthetic
construct) 		PF00240
(ubiquitin) 		4 ILE B  44
GLN B  49
ILE B  23
ASP B  52
 None
EDO  B 101 ( 4.1A)
None
EDO  B 101 (-2.5A)
 0.68A 4z4gA-5v5gB:
undetectable		 4z4gA-5v5gB:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v6a ME.2

(Homo sapiens) 		PF00240
(ubiquitin) 		4 ILE B  44
GLN B  49
ILE B  23
ASP B  52
 None
 0.77A 4z4gA-5v6aB:
undetectable		 4z4gA-5v6aB:
7.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v6t PLEXIN-D1

(Mus musculus) 		PF08337
(Plexin_cytopl) 		4 CYH A1806
ILE A1803
PRO A1768
ILE A1725
 None
 1.04A 4z4gA-5v6tA:
undetectable		 4z4gA-5v6tA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vix POLYUBIQUITIN

(Naegleria
gruberi) 		PF00240
(ubiquitin) 		4 ILE A  44
GLN A  49
ILE A  23
ASP A  52
 None
 0.83A 4z4gA-5vixA:
undetectable		 4z4gA-5vixA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vix POLYUBIQUITIN

(Naegleria
gruberi) 		PF00240
(ubiquitin) 		4 ILE A 120
GLN A 125
ILE A  99
ASP A 128
 NO3  A 201 (-4.5A)
None
None
None
 0.70A 4z4gA-5vixA:
undetectable		 4z4gA-5vixA:
13.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vm9 PROTEIN ARGONAUTE-3

(Homo sapiens) 		no annotation 5 CYH A 692
ILE A 693
PRO A 701
ILE A 703
ASP A 772
 None
 0.49A 4z4gA-5vm9A:
55.6		 4z4gA-5vm9A:
79.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wea PROTEIN ARGONAUTE-2

(Homo sapiens) 		no annotation 7 ARG A 688
CYH A 691
ILE A 692
GLN A 699
PRO A 700
ILE A 702
ASP A 771
 None
 0.64A 4z4gA-5weaA:
58.7		 4z4gA-5weaA:
99.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wea PROTEIN ARGONAUTE-2

(Homo sapiens) 		no annotation 5 CYH A 691
ILE A 692
GLN A 699
PRO A 700
ILE A 664
 None
 1.46A 4z4gA-5weaA:
58.7		 4z4gA-5weaA:
99.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x0z FLAGELLAR MOTOR
SWITCH PROTEIN
(FLIM)

(Helicobacter
pylori) 		PF02154
(FliM) 		4 CYH E 217
ILE E 216
PRO E 219
ILE E 191
 None
 0.94A 4z4gA-5x0zE:
undetectable		 4z4gA-5x0zE:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z06 BDI_3064 PROTEIN

(Parabacteroides
distasonis) 		no annotation 4 ARG A 586
ILE A 589
GLN A 585
ILE A 583
 None
 0.81A 4z4gA-5z06A:
undetectable		 4z4gA-5z06A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zc2 -

(-) 		no annotation 4 ARG B 240
ILE B  90
GLN B 239
ASP B 237
 None
 1.05A 4z4gA-5zc2B:
undetectable		 4z4gA-5zc2B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3r PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1

(Mus musculus) 		no annotation 4 GLN A2222
PRO A2223
ILE A2224
ASP A2326
 None
 1.00A 4z4gA-6b3rA:
undetectable		 4z4gA-6b3rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c01 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 3

(Homo sapiens) 		no annotation 4 ARG A 455
ILE A 456
PRO A 218
ILE A 223
 None
 0.96A 4z4gA-6c01A:
undetectable		 4z4gA-6c01A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw PROBABLE
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
MBHJ

(Pyrococcus
furiosus) 		no annotation 4 CYH J  38
ILE J  40
PRO J 134
ILE J 139
 SF4  J 201 (-3.0A)
None
None
None
 1.03A 4z4gA-6cfwJ:
2.2		 4z4gA-6cfwJ:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gng -

(-) 		no annotation 4 ILE A 483
GLN A 242
PRO A 243
ILE A 245
 None
 1.07A 4z4gA-6gngA:
2.5		 4z4gA-6gngA:
undetectable