SIMILAR PATTERNS OF AMINO ACIDS FOR 4Z4F_A_IPHA904

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cb8 PROTEIN
(CHONDROITINASE AC)

(Pedobacter
heparinus) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		4 ASP A 416
LYS A 564
THR A 485
THR A 487
 CA  A3000 ( 3.5A)
None
None
None
 1.25A 4z4fA-1cb8A:
undetectable		 4z4fA-1cb8A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezr NUCLEOSIDE HYDROLASE

(Leishmania
major) 		PF01156
(IU_nuc_hydro) 		4 ALA A 197
LYS A 238
THR A 200
TYR A 236
 None
 1.27A 4z4fA-1ezrA:
undetectable		 4z4fA-1ezrA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j31 HYPOTHETICAL PROTEIN
PH0642

(Pyrococcus
horikoshii) 		PF00795
(CN_hydrolase) 		4 ASP A  45
ALA A  85
THR A  68
THR A  69
 None
 1.48A 4z4fA-1j31A:
2.4		 4z4fA-1j31A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR

(Escherichia
coli) 		PF00356
(LacI)
PF13377
(Peripla_BP_3) 		4 ASP A 275
ALA A 251
THR A 289
TYR A 274
 HPA  A 599 (-2.8A)
None
None
None
 1.02A 4z4fA-1jftA:
7.4		 4z4fA-1jftA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js6 DOPA DECARBOXYLASE

(Sus scrofa) 		PF00282
(Pyridoxal_deC) 		4 ASP A 271
ALA A 275
THR A 242
THR A 245
 PLP  A 601 (-2.9A)
None
PLP  A 601 ( 4.6A)
None
 1.46A 4z4fA-1js6A:
2.1		 4z4fA-1js6A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lml LEISHMANOLYSIN

(Leishmania
major) 		PF01457
(Peptidase_M8) 		4 ASP A 342
ALA A 340
THR A 355
TYR A 353
 None
 1.41A 4z4fA-1lmlA:
0.0		 4z4fA-1lmlA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o0x METHIONINE
AMINOPEPTIDASE

(Thermotoga
maritima) 		PF00557
(Peptidase_M24) 		4 ASP A 111
ALA A  21
THR A 240
THR A 252
 None
 1.47A 4z4fA-1o0xA:
undetectable		 4z4fA-1o0xA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pzs SUPEROXIDE DISMUTASE
[CU-ZN]

(Mycobacterium
tuberculosis) 		PF00080
(Sod_Cu) 		4 ASP A 158
ALA A 133
THR A 156
THR A 155
 None
 1.40A 4z4fA-1pzsA:
undetectable		 4z4fA-1pzsA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1un9 DIHYDROXYACETONE
KINASE

(Citrobacter
freundii) 		PF02733
(Dak1)
PF02734
(Dak2) 		4 ASP A  89
ALA A 121
LYS A 124
THR A  93
 None
 1.37A 4z4fA-1un9A:
3.2		 4z4fA-1un9A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v96 HYPOTHETICAL PROTEIN
PH0500

(Pyrococcus
horikoshii) 		no annotation 4 ASP A 116
THR A 114
THR A 130
TYR A 120
 None
 1.41A 4z4fA-1v96A:
undetectable		 4z4fA-1v96A:
11.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve4 ATP
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus) 		PF01634
(HisG) 		4 ASP A  78
ALA A 120
THR A 113
TYR A 115
 None
 1.48A 4z4fA-1ve4A:
undetectable		 4z4fA-1ve4A:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w2w 5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE
5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF01008
(IF-2B)
PF01008
(IF-2B) 		4 ASP A 147
ALA A  57
THR B 315
THR B 316
 None
 1.41A 4z4fA-1w2wA:
2.5		 4z4fA-1w2wA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcz GLUTAMYL
ENDOPEPTIDASE

(Staphylococcus
aureus) 		PF13365
(Trypsin_2) 		4 ASP A  59
ALA A  82
LYS A  64
THR A  56
 None
 1.29A 4z4fA-1wczA:
undetectable		 4z4fA-1wczA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wra TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/CHOLINE
BINDING PROTEIN E
(CBPE)

(Streptococcus
pneumoniae) 		PF00753
(Lactamase_B) 		4 ASP A 207
LYS A 134
THR A 111
TYR A 136
 None
 1.44A 4z4fA-1wraA:
undetectable		 4z4fA-1wraA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y82 HYPOTHETICAL PROTEIN

(Pyrococcus
furiosus) 		PF01850
(PIN) 		4 ASP A 116
THR A 114
THR A 130
TYR A 120
 None
None
None
UNX  A 335 (-4.7A)
 1.34A 4z4fA-1y82A:
2.4		 4z4fA-1y82A:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE

(Pseudomonas
putida) 		PF01011
(PQQ)
PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3) 		4 ASP A 297
ALA A 303
THR A 294
TYR A 301
 None
 1.30A 4z4fA-1yiqA:
undetectable		 4z4fA-1yiqA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b61 HOMOSERINE
O-ACETYLTRANSFERASE

(Haemophilus
influenzae) 		PF00561
(Abhydrolase_1) 		4 ASP A 334
ALA A 339
THR A 221
THR A 303
 None
 1.46A 4z4fA-2b61A:
3.1		 4z4fA-2b61A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bib TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/ CHOLINE
BINDING PROTEIN

(Streptococcus
pneumoniae) 		PF00753
(Lactamase_B)
PF01473
(CW_binding_1) 		4 ASP A 182
LYS A 109
THR A  86
TYR A 111
 None
 1.45A 4z4fA-2bibA:
undetectable		 4z4fA-2bibA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0o DIOL
DEHYDRATASE-REACTIVA
TING FACTOR LARGE
SUBUNIT

(Klebsiella
oxytoca) 		PF08841
(DDR) 		4 ASP A   8
LYS A  41
THR A  14
THR A  37
 MG  A1003 ( 4.1A)
None
None
None
 1.31A 4z4fA-2d0oA:
4.1		 4z4fA-2d0oA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2egg SHIKIMATE
5-DEHYDROGENASE

(Geobacillus
kaustophilus) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		4 ASP A 123
ALA A 101
THR A 122
THR A 109
 None
 1.42A 4z4fA-2eggA:
undetectable		 4z4fA-2eggA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fe0 SMALL MYRISTOYLATED
PROTEIN 1

(Leishmania
major) 		PF09149
(DUF1935) 		4 ALA A  49
THR A  98
THR A  20
TYR A  51
 None
 1.36A 4z4fA-2fe0A:
undetectable		 4z4fA-2fe0A:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i2x METHYLTRANSFERASE 1

(Methanosarcina
barkeri) 		PF02310
(B12-binding)
PF02607
(B12-binding_2) 		4 ASP B 134
ALA B 213
THR B 187
THR B 186
 B13  B 500 (-4.3A)
B13  B 500 ( 4.8A)
None
None
 1.42A 4z4fA-2i2xB:
5.5		 4z4fA-2i2xB:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l5a HISTONE H3-LIKE
CENTROMERIC PROTEIN
CSE4, PROTEIN SCM3,
HISTONE H4

(Saccharomyces
cerevisiae) 		PF00125
(Histone)
PF10384
(Scm3)
PF15511
(CENP-T_C) 		4 ASP A 208
ALA A  31
THR A 205
THR A 203
 None
 1.43A 4z4fA-2l5aA:
undetectable		 4z4fA-2l5aA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvo RO SIXTY-RELATED
PROTEIN, RSR

(Deinococcus
radiodurans) 		PF05731
(TROVE) 		4 ASP A 462
ALA A 496
THR A 461
THR A 465
 CA  A 533 ( 4.3A)
None
None
None
 1.44A 4z4fA-2nvoA:
3.4		 4z4fA-2nvoA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5v DNA REPLICATION AND
REPAIR PROTEIN RECF

(Deinococcus
radiodurans) 		PF02463
(SMC_N) 		4 ALA A 229
THR A 246
THR A 222
TYR A 227
 None
 1.24A 4z4fA-2o5vA:
undetectable		 4z4fA-2o5vA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uu7 GLUTAMINE SYNTHETASE

(Canis lupus) 		PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N) 		4 ASP A 239
ALA A 250
THR A 237
THR A 138
 None
 1.41A 4z4fA-2uu7A:
undetectable		 4z4fA-2uu7A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uu7 GLUTAMINE SYNTHETASE

(Canis lupus) 		PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N) 		4 ASP A 239
ALA A 344
THR A 237
THR A 138
 None
 1.42A 4z4fA-2uu7A:
undetectable		 4z4fA-2uu7A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpw THIOSULFATE
REDUCTASE

(Thermus
thermophilus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 ASP A 275
LYS A 281
THR A 283
TYR A 278
 None
 1.11A 4z4fA-2vpwA:
undetectable		 4z4fA-2vpwA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w48 SORBITOL OPERON
REGULATOR

(Klebsiella
pneumoniae) 		PF04198
(Sugar-bind)
PF13936
(HTH_38) 		4 ALA A  28
THR A  37
THR A  36
TYR A  34
 None
 1.49A 4z4fA-2w48A:
undetectable		 4z4fA-2w48A:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7c TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN

(Escherichia
coli) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		4 ALA B 146
THR B 221
THR B 178
TYR B 149
 None
 1.48A 4z4fA-2y7cB:
undetectable		 4z4fA-2y7cB:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d9r KETOSTEROID
ISOMERASE-LIKE
PROTEIN

(Pectobacterium
atrosepticum) 		PF12680
(SnoaL_2) 		4 ALA A  15
THR A  34
THR A 124
TYR A  19
 None
None
None
UNL  A 136 (-4.8A)
 1.14A 4z4fA-3d9rA:
undetectable		 4z4fA-3d9rA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dg7 MUCONATE
CYCLOISOMERASE

(Mycolicibacterium
smegmatis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ALA A 268
LYS A 266
THR A 301
THR A 304
 None
MUC  A1001 (-2.9A)
None
None
 1.38A 4z4fA-3dg7A:
3.9		 4z4fA-3dg7A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3doo SHIKIMATE
DEHYDROGENASE

(Staphylococcus
epidermidis) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		4 ASP A 100
ALA A  78
THR A  99
THR A  86
 SKM  A 300 (-2.9A)
None
None
None
 1.47A 4z4fA-3dooA:
undetectable		 4z4fA-3dooA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fbg PUTATIVE ARGINATE
LYASE

(Staphylococcus
haemolyticus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ASP A 226
ALA A 247
THR A 225
THR A 244
 None
 1.44A 4z4fA-3fbgA:
undetectable		 4z4fA-3fbgA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyx ADENYLYLSULFATE
REDUCTASE

(Desulfovibrio
gigas) 		PF00890
(FAD_binding_2) 		4 ALA A 257
THR A 603
THR A 262
TYR A 261
 None
 1.14A 4z4fA-3gyxA:
undetectable		 4z4fA-3gyxA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		4 ASP A  87
THR A 296
THR A 295
TYR A 328
 CA  A 601 (-2.1A)
None
None
None
 1.47A 4z4fA-3hjrA:
undetectable		 4z4fA-3hjrA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3v PROBABLE SECRETED
SOLUTE-BINDING
LIPOPROTEIN

(Streptomyces
coelicolor) 		PF01547
(SBP_bac_1) 		4 ASP A 119
ALA A 150
THR A 112
THR A 117
 None
 1.15A 4z4fA-3i3vA:
2.1		 4z4fA-3i3vA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kb6 D-LACTATE
DEHYDROGENASE

(Aquifex
aeolicus) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 ASP A  76
ALA A 230
THR A 208
TYR A 204
 PPI  A 453 (-3.9A)
NAD  A 400 (-4.6A)
NAD  A 400 (-4.7A)
None
 1.12A 4z4fA-3kb6A:
3.1		 4z4fA-3kb6A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE

(Babesia bovis) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		4 ASP A 458
ALA A 253
THR A 251
THR A 249
 None
 1.15A 4z4fA-3kjrA:
undetectable		 4z4fA-3kjrA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2

(Dichelobacter
nodosus) 		PF00082
(Peptidase_S8) 		4 ASP A  49
ALA A 124
THR A 257
TYR A 270
 CA  A   1 (-2.2A)
None
None
None
 1.37A 4z4fA-3lpdA:
2.0		 4z4fA-3lpdA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oib ACYL-COA
DEHYDROGENASE

(Mycolicibacterium
smegmatis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ASP A 229
ALA A 185
THR A 180
THR A 112
 None
None
FDA  A 518 (-3.9A)
None
 1.36A 4z4fA-3oibA:
undetectable		 4z4fA-3oibA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ojl CAP5O

(Staphylococcus
aureus) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		4 ASP A 262
ALA A 121
THR A 119
THR A  82
 None
None
NAD  A 500 (-3.7A)
NAD  A 500 (-3.1A)
 1.26A 4z4fA-3ojlA:
undetectable		 4z4fA-3ojlA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qlb ENANTIO-PYOCHELIN
RECEPTOR

(Pseudomonas
fluorescens) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 ASP A 564
ALA A  31
THR A  59
TYR A  33
 None
 1.46A 4z4fA-3qlbA:
undetectable		 4z4fA-3qlbA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qpc CUTINASE

(Fusarium solani) 		PF01083
(Cutinase) 		4 ALA A 127
THR A 144
THR A 167
TYR A 162
 None
 1.28A 4z4fA-3qpcA:
undetectable		 4z4fA-3qpcA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r7k PROBABLE ACYL COA
DEHYDROGENASE

(Mycobacteroides
abscessus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ASP A 228
ALA A 184
THR A 179
THR A 111
 None
None
FDA  A 420 (-4.0A)
None
 1.37A 4z4fA-3r7kA:
undetectable		 4z4fA-3r7kA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sl1 ARGINASE

(Plasmodium
falciparum) 		PF00491
(Arginase) 		4 ASP A 293
THR A 302
THR A 305
TYR A 289
 None
 1.38A 4z4fA-3sl1A:
4.2		 4z4fA-3sl1A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6s CERJ

(Streptomyces
tendae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 ALA A  61
THR A 144
THR A 143
TYR A 302
 None
 1.44A 4z4fA-3t6sA:
undetectable		 4z4fA-3t6sA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV

(Dichelobacter
nodosus) 		PF00082
(Peptidase_S8) 		4 ASP A  49
ALA A 124
THR A 257
TYR A 270
 CA  A 353 (-2.3A)
None
None
None
 1.33A 4z4fA-3ti7A:
undetectable		 4z4fA-3ti7A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3voh CELLOBIOHYDROLASE

(Coprinopsis
cinerea) 		PF01341
(Glyco_hydro_6) 		4 ASP A 314
ALA A 256
THR A 307
TYR A 313
 None
 1.28A 4z4fA-3vohA:
undetectable		 4z4fA-3vohA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wyf RAN-SPECIFIC
GTPASE-ACTIVATING
PROTEIN 2

(Saccharomyces
cerevisiae) 		PF00638
(Ran_BP1) 		4 ALA B 220
LYS B 307
THR B 313
THR B 314
 None
 1.34A 4z4fA-3wyfB:
undetectable		 4z4fA-3wyfB:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci0 F420-REDUCING
HYDROGENASE, SUBUNIT
GAMMA

(Methanothermobacter
marburgensis) 		PF00037
(Fer4)
PF01058
(Oxidored_q6) 		4 ALA B 167
THR B 135
THR B 203
TYR B 202
 None
 1.36A 4z4fA-4ci0B:
2.4		 4z4fA-4ci0B:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cxk ARYLSULFATASE

(Pseudomonas
aeruginosa) 		PF00884
(Sulfatase) 		4 ASP A 317
ALA A  50
LYS A 375
THR A  47
 CA  A1528 (-2.0A)
DDZ  A  51 ( 3.1A)
SO4  A1529 (-2.8A)
None
 1.10A 4z4fA-4cxkA:
undetectable		 4z4fA-4cxkA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dd5 ACETYL-COA
ACETYLTRANSFERASE

(Clostridioides
difficile) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 ALA A 286
LYS A 303
THR A 390
THR A 391
 None
 1.34A 4z4fA-4dd5A:
undetectable		 4z4fA-4dd5A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4djh KAPPA-TYPE OPIOID
RECEPTOR, LYSOZYME

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 ASP A 155
ALA A 166
THR A  94
THR A  92
 None
 1.46A 4z4fA-4djhA:
undetectable		 4z4fA-4djhA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h0f LAMININ-BINDING
SURFACE PROTEIN

(Streptococcus
agalactiae) 		PF01297
(ZnuA) 		4 ASP A 140
ALA A 208
THR A 145
TYR A 211
 None
ZN  A 401 ( 4.0A)
None
None
 1.46A 4z4fA-4h0fA:
2.0		 4z4fA-4h0fA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpv S-ADENOSYLMETHIONINE
SYNTHASE

(Sulfolobus
solfataricus) 		PF01941
(AdoMet_Synthase) 		4 ASP A 199
ALA A 278
THR A 272
THR A 274
 None
 1.39A 4z4fA-4hpvA:
undetectable		 4z4fA-4hpvA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4huc PROBABLE CONSERVED
LIPOPROTEIN LPPS

(Mycobacterium
tuberculosis) 		PF03734
(YkuD) 		4 ASP A 367
ALA A 362
THR A 326
TYR A 366
 None
 1.32A 4z4fA-4hucA:
undetectable		 4z4fA-4hucA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ij5 PHOSPHOSERINE
PHOSPHATASE 1

(Hydrogenobacter
thermophilus) 		PF00300
(His_Phos_1) 		4 ASP A 175
ALA A 177
THR A 197
TYR A 204
 None
 1.23A 4z4fA-4ij5A:
undetectable		 4z4fA-4ij5A:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iy9 30K PROTEIN 1

(Bombyx mori) 		PF03260
(Lipoprotein_11) 		4 ASP A 121
ALA A 100
LYS A  91
THR A 102
 None
 1.36A 4z4fA-4iy9A:
undetectable		 4z4fA-4iy9A:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jng NUCLEOCAPSID PROTEIN

(Sathuperi
orthobunyavirus) 		PF00952
(Bunya_nucleocap) 		4 ASP A 156
ALA A 154
THR A 139
TYR A 158
 None
 1.38A 4z4fA-4jngA:
undetectable		 4z4fA-4jngA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jnq THIOREDOXIN
REDUCTASE

(Brucella
melitensis) 		PF07992
(Pyr_redox_2) 		4 ASP A 289
ALA A 284
THR A 288
THR A 269
 None
None
None
NA  A 402 (-3.3A)
 1.36A 4z4fA-4jnqA:
undetectable		 4z4fA-4jnqA:
18.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4krf PROTEIN ARGONAUTE-1

(Homo sapiens) 		PF02170
(PAZ)
PF02171
(Piwi)
PF08699
(ArgoL1)
PF16486
(ArgoN)
PF16487
(ArgoMid)
PF16488
(ArgoL2) 		6 ASP A 535
ALA A 541
LYS A 568
THR A 850
THR A 853
TYR A 855
 None
None
U  R   1 ( 3.2A)
None
None
None
 0.17A 4z4fA-4krfA:
61.7		 4z4fA-4krfA:
82.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kzs LPP20 LIPOFAMILY
PROTEIN

(Helicobacter
pylori) 		PF02169
(LPP20) 		4 ALA A  44
LYS A  53
THR A 115
TYR A 114
 None
 1.21A 4z4fA-4kzsA:
undetectable		 4z4fA-4kzsA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lbw ELONGATION FACTOR
TU-A

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		4 ASP A  51
ALA A  66
THR A  25
THR A  28
 MG  A 502 (-4.0A)
NH4  A 503 ( 4.0A)
MG  A 502 ( 3.1A)
None
 1.46A 4z4fA-4lbwA:
5.2		 4z4fA-4lbwA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lws UNCHARACTERIZED
PROTEIN
UNCHARACTERIZED
PROTEIN

(Thermomonospora
curvata;
Thermomonospora
curvata) 		PF06013
(WXG100)
PF06013
(WXG100) 		4 ASP B  45
THR A  80
THR A  83
TYR A  84
 None
 1.25A 4z4fA-4lwsB:
undetectable		 4z4fA-4lwsB:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4np4 TOXIN B

(Clostridioides
difficile) 		PF01473
(CW_binding_1) 		4 ASP A1924
ALA A1922
LYS A1906
TYR A1942
 None
 1.45A 4z4fA-4np4A:
undetectable		 4z4fA-4np4A:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6r ALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		4 ASP A  16
ALA A  36
THR A  38
THR A 207
 None
 1.46A 4z4fA-4o6rA:
3.3		 4z4fA-4o6rA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p4g SHIKIMATE
5-DEHYDROGENASE AROE
(5-DEHYDROSHIKIMATE
REDUCTASE)

(Mycobacterium
tuberculosis) 		PF08501
(Shikimate_dh_N) 		4 ASP A 105
ALA A 132
THR A 128
THR A 191
 SKM  A 301 (-2.8A)
None
None
None
 1.49A 4z4fA-4p4gA:
undetectable		 4z4fA-4p4gA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qtf L,D-TRANSPEPTIDASE
LDTB

(Mycobacterium
tuberculosis) 		PF03734
(YkuD) 		4 ASP A 367
ALA A 362
THR A 326
TYR A 366
 None
 1.31A 4z4fA-4qtfA:
undetectable		 4z4fA-4qtfA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhb LPS-ASSEMBLY PROTEIN
LPTD

(Escherichia
coli) 		PF04453
(OstA_C) 		4 ASP A 569
ALA A 571
THR A 505
TYR A 504
 None
 1.47A 4z4fA-4rhbA:
undetectable		 4z4fA-4rhbA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rv3 1-PHOSPHATIDYLINOSIT
OL PHOSPHODIESTERASE

(Staphylococcus
aureus) 		PF00388
(PI-PLC-X) 		4 ASP A  31
ALA A  46
THR A  48
THR A 252
 INS  A 402 ( 4.3A)
None
None
None
 0.96A 4z4fA-4rv3A:
undetectable		 4z4fA-4rv3A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1a ENOYL-COA DELTA
ISOMERASE 2

(Homo sapiens) 		PF00378
(ECH_1) 		4 ASP A 147
ALA A 140
THR A 116
THR A 152
 None
 1.26A 4z4fA-4u1aA:
undetectable		 4z4fA-4u1aA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uhh ESTERASE

(Thermogutta
terrifontis) 		PF00561
(Abhydrolase_1) 		4 ASP A  81
ALA A  83
THR A   9
THR A  10
 None
 1.33A 4z4fA-4uhhA:
2.1		 4z4fA-4uhhA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c7q NUDF PROTEIN

(Bdellovibrio
bacteriovorus) 		PF00293
(NUDIX) 		4 ASP A 122
ALA A  45
THR A  85
THR A  88
 None
GOL  A 207 (-3.5A)
None
None
 1.47A 4z4fA-5c7qA:
undetectable		 4z4fA-5c7qA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czr CADHERIN-RELATED
FAMILY MEMBER 2

(Homo sapiens) 		PF00028
(Cadherin) 		4 ASP A  99
ALA A 136
THR A 198
TYR A 193
 CA  A1002 ( 2.7A)
CA  A1004 (-4.4A)
None
None
 1.37A 4z4fA-5czrA:
undetectable		 4z4fA-5czrA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ep8 PYRIMIDINE-NUCLEOSID
E PHOSPHORYLASE

(Bacillus
subtilis) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		4 ASP A 213
ALA A 215
THR A 210
THR A 202
 ASP  A 213 ( 0.6A)
ALA  A 215 ( 0.0A)
THR  A 210 ( 0.8A)
THR  A 202 ( 0.8A)
 1.44A 4z4fA-5ep8A:
undetectable		 4z4fA-5ep8A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey8 ACYL-COA SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00501
(AMP-binding) 		4 ASP A  89
ALA A 161
THR A 134
THR A 135
 None
 1.46A 4z4fA-5ey8A:
2.1		 4z4fA-5ey8A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hab RIBONUCLEASE J

(Methanolobus
psychrophilus) 		PF07521
(RMMBL)
PF12706
(Lactamase_B_2) 		4 ASP A 174
ALA A 172
THR A 157
THR A 150
 A  C   2 ( 4.1A)
None
None
None
 1.32A 4z4fA-5habA:
undetectable		 4z4fA-5habA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hlb PENICILLIN-BINDING
PROTEIN 1B

(Escherichia
coli) 		PF00905
(Transpeptidase)
PF00912
(Transgly)
PF14814
(UB2H) 		4 ALA A 450
THR A 719
THR A 721
TYR A 743
 None
 1.29A 4z4fA-5hlbA:
undetectable		 4z4fA-5hlbA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hra ASPARTATE/GLUTAMATE
RACEMASE

(Escherichia
coli) 		PF01177
(Asp_Glu_race) 		4 LYS A  88
THR A 125
THR A  85
TYR A 127
 None
DAS  A 301 ( 4.1A)
DAS  A 301 (-3.7A)
None
 1.48A 4z4fA-5hraA:
2.2		 4z4fA-5hraA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5im2 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL

(Rhodoferax
ferrireducens) 		PF03480
(DctP) 		4 ASP A  80
ALA A  76
THR A  92
TYR A  79
 None
 1.13A 4z4fA-5im2A:
undetectable		 4z4fA-5im2A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jp0 BETA-GLUCOSIDASE
BOGH3B

(Bacteroides
ovatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 ALA A 173
LYS A 104
THR A 136
THR A 139
 None
 1.17A 4z4fA-5jp0A:
3.4		 4z4fA-5jp0A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jrj PROTEIN RECA

(Herbaspirillum
seropedicae) 		PF00154
(RecA) 		4 ASP A 146
ALA A 144
THR A 194
THR A 192
 None
 1.27A 4z4fA-5jrjA:
2.8		 4z4fA-5jrjA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jta NEUTRAL TREHALASE

(Saccharomyces
cerevisiae) 		no annotation 4 ASP A 516
ALA A 507
LYS A 533
THR A 528
 None
 1.26A 4z4fA-5jtaA:
undetectable		 4z4fA-5jtaA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kss 5'-NUCLEOTIDASE SURE

(Xylella
fastidiosa) 		PF01975
(SurE) 		4 ASP A 222
LYS A 179
THR A 219
THR A 181
 None
 1.43A 4z4fA-5kssA:
3.9		 4z4fA-5kssA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l8s AMINO ACYL PEPTIDASE

(Sporosarcina
psychrophila) 		PF00326
(Peptidase_S9) 		4 ASP A 369
LYS A 451
THR A 402
THR A 373
 SO4  A 701 (-3.7A)
None
SO4  A 701 ( 4.9A)
None
 1.25A 4z4fA-5l8sA:
2.1		 4z4fA-5l8sA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5min QUINOPROTEIN GLUCOSE
DEHYDROGENASE B

(Acinetobacter
calcoaceticus) 		no annotation 4 ALA A 269
THR A 323
THR A 326
TYR A 271
 CA  A 502 (-4.6A)
None
None
None
 1.28A 4z4fA-5minA:
undetectable		 4z4fA-5minA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oex -

(-) 		no annotation 4 ASP A 529
ALA A 485
THR A 483
THR A 496
 None
None
CU  A 604 ( 4.8A)
None
 1.45A 4z4fA-5oexA:
undetectable		 4z4fA-5oexA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swv PENTAFUNCTIONAL AROM
POLYPEPTIDE

(Schizosaccharomyces
pombe) 		PF01487
(DHquinase_I)
PF08501
(Shikimate_dh_N) 		4 ASP C1395
ALA C1369
THR C1394
THR C1377
 None
 1.46A 4z4fA-5swvC:
undetectable		 4z4fA-5swvC:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj6 HIGH CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL

(Aplysia
californica) 		PF00520
(Ion_trans)
PF03493
(BK_channel_a) 		4 ASP A 250
ALA A 258
THR A 286
THR A 285
 None
 1.48A 4z4fA-5tj6A:
3.4		 4z4fA-5tj6A:
21.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vm9 PROTEIN ARGONAUTE-3

(Homo sapiens) 		no annotation 5 ASP A 538
ALA A 544
LYS A 571
THR A 853
THR A 856
 None
None
A  B   1 ( 2.9A)
None
None
 0.69A 4z4fA-5vm9A:
58.0		 4z4fA-5vm9A:
79.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vm9 PROTEIN ARGONAUTE-3

(Homo sapiens) 		no annotation 5 ASP A 538
ALA A 544
LYS A 571
THR A 856
TYR A 858
 None
None
A  B   1 ( 2.9A)
None
None
 0.61A 4z4fA-5vm9A:
58.0		 4z4fA-5vm9A:
79.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wea PROTEIN ARGONAUTE-2

(Homo sapiens) 		no annotation 5 ASP A 537
ALA A 543
LYS A 570
THR A 852
TYR A 857
 None
None
A  B   1 ( 4.0A)
None
None
 0.68A 4z4fA-5weaA:
57.4		 4z4fA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wea PROTEIN ARGONAUTE-2

(Homo sapiens) 		no annotation 4 ASP A 537
ALA A 543
LYS A 570
THR A 855
 None
None
A  B   1 ( 4.0A)
None
 1.16A 4z4fA-5weaA:
57.4		 4z4fA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wtf VP1

(Hepatovirus A) 		PF12944
(HAV_VP) 		4 ASP A  57
ALA A  61
THR A  54
THR A  53
 None
 1.31A 4z4fA-5wtfA:
undetectable		 4z4fA-5wtfA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi GUANINE
NUCLEOTIDE-BINDING
PROTEIN BETA
SUBUNIT, PUTATIVE

(Trichomonas
vaginalis) 		no annotation 4 ASP g 324
ALA g  35
THR g 307
TYR g 322
 None
 1.31A 4z4fA-5xyig:
undetectable		 4z4fA-5xyig:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yl7 PSEUDOALTEROMONAS
ARCTICA PAMC 21717

(Pseudoalteromonas
arctica) 		no annotation 4 ASP A 193
ALA A 263
THR A 405
TYR A 418
 CA  A 801 (-2.2A)
None
None
None
 1.43A 4z4fA-5yl7A:
undetectable		 4z4fA-5yl7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aso U4/U6
SNRNA-ASSOCIATED-SPL
ICING FACTOR PRP24

(Saccharomyces
cerevisiae) 		no annotation 4 ASP A  91
ALA A  88
THR A  41
TYR A  90
 None
 1.42A 4z4fA-6asoA:
2.8		 4z4fA-6asoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aun PLA2G6, IPLA2BETA

(Cricetulus
griseus) 		no annotation 4 ASP A 430
ALA A 462
THR A 464
THR A 531
 None
 1.48A 4z4fA-6aunA:
4.7		 4z4fA-6aunA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfi VIN1

(Oscarella
pearsei) 		no annotation 4 ASP A 789
ALA A 778
LYS A 719
THR A 709
 None
 1.40A 4z4fA-6bfiA:
undetectable		 4z4fA-6bfiA:
undetectable