SIMILAR PATTERNS OF AMINO ACIDS FOR 4Z4F_A_IPHA903

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
BETA SUBUNIT

(Saccharomyces
cerevisiae) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 VAL B 439
ALA B 271
PHE B 251
THR B 170
 None
 1.44A 4z4fA-1hr7B:
0.4		 4z4fA-1hr7B:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x2g LIPOATE-PROTEIN
LIGASE A

(Escherichia
coli) 		PF03099
(BPL_LplA_LipB)
PF10437
(Lip_prot_lig_C) 		4 VAL A 215
ALA A 217
PHE A 208
THR A 204
 None
 1.50A 4z4fA-1x2gA:
0.1		 4z4fA-1x2gA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bi0 HYPOTHETICAL PROTEIN
RV0216

(Mycobacterium
tuberculosis) 		no annotation 4 VAL A 271
ALA A 269
PHE A 102
THR A 187
 None
 1.19A 4z4fA-2bi0A:
0.0		 4z4fA-2bi0A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzh LACCASE

(Trametes
ochracea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 VAL A 125
ALA A 103
PHE A  68
THR A  99
 None
 1.07A 4z4fA-2hzhA:
0.0		 4z4fA-2hzhA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nnj CYTOCHROME P450 2C8

(Homo sapiens) 		PF00067
(p450) 		4 VAL A 296
ALA A 292
PHE A 201
THR A 240
 None
 1.36A 4z4fA-2nnjA:
undetectable		 4z4fA-2nnjA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0a SYNAPSIN-3

(Homo sapiens) 		PF02078
(Synapsin)
PF02750
(Synapsin_C) 		4 VAL A 238
ALA A 240
PHE A 231
THR A 229
 None
 1.36A 4z4fA-2p0aA:
2.9		 4z4fA-2p0aA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2sfa SERINE PROTEINASE

(Streptomyces
fradiae) 		PF00089
(Trypsin) 		4 VAL A 140
ALA A 142
PHE A 176
THR A 161
 None
 1.43A 4z4fA-2sfaA:
undetectable		 4z4fA-2sfaA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl9 GLUTAMYL
AMINOPEPTIDASE

(Streptococcus
pneumoniae) 		PF05343
(Peptidase_M42) 		4 VAL A 340
ALA A 338
PHE A 272
THR A 276
 None
 1.41A 4z4fA-3kl9A:
2.4		 4z4fA-3kl9A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkb PROBABLE
BRANCHED-CHAIN AMINO
ACID ABC
TRANSPORTER, AMINO
ACID BINDING PROTEIN

(Thermus
thermophilus) 		PF13458
(Peripla_BP_6) 		4 VAL A 203
ALA A 230
PHE A 249
THR A 233
 None
 1.27A 4z4fA-3lkbA:
5.9		 4z4fA-3lkbA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qt3 PUTATIVE
UNCHARACTERIZED
PROTEIN CPE0426

(Clostridium
perfringens) 		PF06824
(Glyco_hydro_125) 		4 VAL A 397
ALA A 342
PHE A 395
THR A 384
 None
 1.45A 4z4fA-3qt3A:
undetectable		 4z4fA-3qt3A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qtd PMBA PROTEIN

(Pseudomonas
aeruginosa) 		PF01523
(PmbA_TldD) 		4 VAL A  92
ALA A  78
PHE A  65
THR A  80
 None
 1.32A 4z4fA-3qtdA:
2.7		 4z4fA-3qtdA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e6w CLBP PEPTIDASE

(Escherichia
coli) 		PF00144
(Beta-lactamase) 		4 VAL A 258
ALA A 260
PHE A 206
THR A 101
 None
 1.47A 4z4fA-4e6wA:
undetectable		 4z4fA-4e6wA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fn5 ELONGATION FACTOR G
1

(Pseudomonas
aeruginosa) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		4 VAL A 581
ALA A 600
PHE A 522
THR A 604
 None
 1.45A 4z4fA-4fn5A:
5.0		 4z4fA-4fn5A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9i HYDROGENASE
MATURATION PROTEIN
HYPF

(Thermococcus
kodakarensis) 		PF00708
(Acylphosphatase)
PF00814
(Peptidase_M22)
PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		4 VAL A 524
ALA A 507
PHE A 693
THR A 611
 None
 1.25A 4z4fA-4g9iA:
2.3		 4z4fA-4g9iA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ja0 PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE

(Bombyx mori) 		PF00731
(AIRC)
PF01259
(SAICAR_synt) 		4 VAL A 210
ALA A 208
PHE A  68
THR A  78
 None
 1.40A 4z4fA-4ja0A:
undetectable		 4z4fA-4ja0A:
21.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4krf PROTEIN ARGONAUTE-1

(Homo sapiens) 		PF02170
(PAZ)
PF02171
(Piwi)
PF08699
(ArgoL1)
PF16486
(ArgoN)
PF16487
(ArgoMid)
PF16488
(ArgoL2) 		4 VAL A 589
ALA A 618
PHE A 651
THR A 655
 None
 0.26A 4z4fA-4krfA:
61.7		 4z4fA-4krfA:
82.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mmp SIALIC ACID BINDING
PROTEIN

(Pasteurella
multocida) 		PF03480
(DctP) 		4 VAL A 123
ALA A 244
PHE A  92
THR A 248
 None
 1.48A 4z4fA-4mmpA:
undetectable		 4z4fA-4mmpA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p5p THIJ/PFPI FAMILY
PROTEIN

(Francisella
tularensis) 		PF01965
(DJ-1_PfpI) 		4 VAL A   7
ALA A  99
PHE A 108
THR A 104
 None
 1.31A 4z4fA-4p5pA:
2.7		 4z4fA-4p5pA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4whb PHENYLUREA HYDROLASE
B

(Mycolicibacterium
brisbanense) 		no annotation 4 VAL E 144
ALA E 208
PHE E 231
THR E 230
 None
 1.20A 4z4fA-4whbE:
undetectable		 4z4fA-4whbE:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xsr ALR3699 PROTEIN

(Nostoc sp. PCC
7120) 		no annotation 4 VAL B 304
ALA B 351
PHE B 323
THR B 347
 None
 1.39A 4z4fA-4xsrB:
2.7		 4z4fA-4xsrB:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eco JASMONIC ACID-AMIDO
SYNTHETASE JAR1

(Arabidopsis
thaliana) 		PF03321
(GH3) 		4 VAL A 354
ALA A 339
PHE A  17
THR A 127
 None
 1.40A 4z4fA-5ecoA:
undetectable		 4z4fA-5ecoA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jta NEUTRAL TREHALASE

(Saccharomyces
cerevisiae) 		no annotation 4 VAL A 591
ALA A 594
PHE A 574
THR A 573
 None
 1.38A 4z4fA-5jtaA:
undetectable		 4z4fA-5jtaA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2

(Homo sapiens) 		PF00856
(SET)
PF01753
(zf-MYND) 		4 VAL A  42
ALA A 197
PHE A  56
THR A 220
 None
 1.10A 4z4fA-5kjmA:
undetectable		 4z4fA-5kjmA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m4a NEUTRAL TREHALASE

(Saccharomyces
cerevisiae) 		no annotation 4 VAL A 591
ALA A 594
PHE A 574
THR A 573
 None
 1.40A 4z4fA-5m4aA:
undetectable		 4z4fA-5m4aA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ntf AMINOPEPTIDASE

(Trypanosoma
cruzi) 		PF00883
(Peptidase_M17) 		4 VAL A 394
ALA A 284
PHE A 486
THR A 385
 None
 1.19A 4z4fA-5ntfA:
2.3		 4z4fA-5ntfA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5twa BCL-X HOMOLOGOUS
PROTEIN, BHP2

(Geodia cydonium) 		PF00452
(Bcl-2) 		4 VAL A 136
ALA A 138
PHE A 127
THR A 126
 None
None
EDO  A 308 (-4.2A)
None
 1.38A 4z4fA-5twaA:
undetectable		 4z4fA-5twaA:
12.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vm9 PROTEIN ARGONAUTE-3

(Homo sapiens) 		no annotation 4 VAL A 592
ALA A 621
PHE A 654
THR A 658
 None
 0.39A 4z4fA-5vm9A:
58.0		 4z4fA-5vm9A:
79.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w8p HOMOSERINE
O-ACETYLTRANSFERASE

(Mycobacteroides
abscessus) 		PF00561
(Abhydrolase_1) 		4 VAL A 142
ALA A 144
PHE A  58
THR A 103
 None
 1.21A 4z4fA-5w8pA:
2.2		 4z4fA-5w8pA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wea PROTEIN ARGONAUTE-2

(Homo sapiens) 		no annotation 4 VAL A 591
ALA A 620
PHE A 653
THR A 657
 None
 0.29A 4z4fA-5weaA:
57.4		 4z4fA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6i -

(-) 		no annotation 4 VAL A 229
ALA A 211
PHE A 113
THR A 151
 None
 1.49A 4z4fA-5y6iA:
undetectable		 4z4fA-5y6iA:
undetectable