SIMILAR PATTERNS OF AMINO ACIDS FOR 4Z4F_A_IPHA902_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxk PROTEIN
(DTDP-GLUCOSE
4,6-DEHYDRATASE)


(Escherichia
coli)
PF16363
(GDP_Man_Dehyd)
4 LYS A 277
PRO A 278
LEU A 270
GLU A 271
None
1.04A 4z4fA-1bxkA:
2.3
4z4fA-1bxkA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cli PROTEIN
(PHOSPHORIBOSYL-AMIN
OIMIDAZOLE
SYNTHETASE)


(Escherichia
coli)
PF00586
(AIRS)
PF02769
(AIRS_C)
4 LEU A 222
PRO A 189
LEU A  73
TYR A 194
None
1.02A 4z4fA-1cliA:
2.0
4z4fA-1cliA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE


(Geobacillus
stearothermophilus)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
4 LEU A 170
PRO A  54
LEU A 191
GLU A 190
None
1.07A 4z4fA-1ebdA:
undetectable
4z4fA-1ebdA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fp9 4-ALPHA-GLUCANOTRANS
FERASE


(Thermus
thermophilus)
PF02446
(Glyco_hydro_77)
4 LEU A 438
PRO A 378
LEU A 418
TYR A 417
None
0.99A 4z4fA-1fp9A:
undetectable
4z4fA-1fp9A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1guz MALATE DEHYDROGENASE

(Chlorobaculum
tepidum;
Prosthecochloris
vibrioformis)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
4 LEU A 171
PRO A 267
LEU A 291
TYR A 257
None
1.07A 4z4fA-1guzA:
undetectable
4z4fA-1guzA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gv0 MALATE DEHYDROGENASE

(Chlorobaculum
tepidum)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
4 LEU A 171
PRO A 267
LEU A 291
TYR A 257
None
1.06A 4z4fA-1gv0A:
undetectable
4z4fA-1gv0A:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hcy ARTHROPODAN
HEMOCYANIN


(Panulirus
interruptus)
PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C)
4 LEU A  18
PRO A 135
LEU A 119
TYR A 120
None
0.97A 4z4fA-1hcyA:
0.0
4z4fA-1hcyA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jig DLP-2

(Bacillus
anthracis)
PF00210
(Ferritin)
4 LEU A  21
TYR A  54
LEU A 105
TYR A 102
None
1.04A 4z4fA-1jigA:
undetectable
4z4fA-1jigA:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1knb ADENOVIRUS TYPE 5
FIBER PROTEIN


(Human
mastadenovirus
C)
PF00541
(Adeno_knob)
4 LYS A 528
PRO A 529
GLU A 566
TYR A 563
None
0.86A 4z4fA-1knbA:
undetectable
4z4fA-1knbA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m3u 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE


(Escherichia
coli)
PF02548
(Pantoate_transf)
4 LEU A 213
LYS A 231
GLU A 250
TYR A 256
None
0.93A 4z4fA-1m3uA:
undetectable
4z4fA-1m3uA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ni6 HEME OXYGENASE 1

(Homo sapiens)
PF01126
(Heme_oxygenase)
4 LEU A  49
PRO A 106
LEU A 217
GLU A 216
None
1.05A 4z4fA-1ni6A:
undetectable
4z4fA-1ni6A:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvm CONSERVED
HYPOTHETICAL PROTEIN
TA0289


(Thermoplasma
acidophilum)
PF00571
(CBS)
PF09151
(DUF1936)
4 LEU A 100
PRO A  80
LEU A  95
TYR A  94
None
0.85A 4z4fA-1pvmA:
undetectable
4z4fA-1pvmA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhv PROTEIN (ADENOVIRUS
FIBRE)


(Human
mastadenovirus
C)
PF00541
(Adeno_knob)
4 LYS A 528
PRO A 529
GLU A 567
TYR A 564
None
0.96A 4z4fA-1qhvA:
undetectable
4z4fA-1qhvA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qiu ADENOVIRUS FIBRE

(Human
mastadenovirus
C)
PF00541
(Adeno_knob)
PF00608
(Adeno_shaft)
4 LYS A 528
PRO A 529
GLU A 567
TYR A 564
None
0.98A 4z4fA-1qiuA:
undetectable
4z4fA-1qiuA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tt4 PUTATIVE CYTOPLASMIC
PROTEIN


(Salmonella
enterica)
PF04107
(GCS2)
4 LEU A 264
PRO A 269
LEU A 150
TYR A 149
None
1.06A 4z4fA-1tt4A:
undetectable
4z4fA-1tt4A:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xi8 MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN


(Pyrococcus
furiosus)
PF00994
(MoCF_biosynth)
PF03453
(MoeA_N)
PF03454
(MoeA_C)
4 LEU A 315
LYS A 182
PRO A 183
GLU A 221
None
0.91A 4z4fA-1xi8A:
4.6
4z4fA-1xi8A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3


(Thermoplasma
acidophilum)
PF01433
(Peptidase_M1)
PF11838
(ERAP1_C)
4 LEU A 461
LYS A 401
PRO A 402
TYR A 364
None
0.86A 4z4fA-1z1wA:
3.8
4z4fA-1z1wA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zk7 MERCURIC REDUCTASE

(Pseudomonas
aeruginosa)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
4 LEU A 170
PRO A  49
LEU A 191
GLU A 190
None
None
None
FAD  A 666 ( 4.7A)
1.07A 4z4fA-1zk7A:
undetectable
4z4fA-1zk7A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dh4 YPL069C

(Saccharomyces
cerevisiae)
PF00348
(polyprenyl_synt)
4 TYR A 216
LYS A 220
LEU A 283
GLU A 284
None
0.95A 4z4fA-2dh4A:
undetectable
4z4fA-2dh4A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1


(Crotalus atrox)
PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR)
4 LEU A 383
PRO A 388
LEU A 195
TYR A 194
None
0.93A 4z4fA-2erqA:
4.3
4z4fA-2erqA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2esf CARBONIC ANHYDRASE 2

(Escherichia
coli)
PF00484
(Pro_CA)
4 LEU A 134
LYS A 129
LEU A 149
GLU A 153
None
1.06A 4z4fA-2esfA:
3.6
4z4fA-2esfA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g1s RENIN

(Homo sapiens)
PF00026
(Asp)
4 LEU A 241
PRO A 261
LEU A 293
TYR A 279
None
0.72A 4z4fA-2g1sA:
undetectable
4z4fA-2g1sA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hq4 HYPOTHETICAL PROTEIN
PH1570


(Pyrococcus
horikoshii)
PF09638
(Ph1570)
4 LEU A  35
TYR A  39
LEU A  65
GLU A  66
None
0.95A 4z4fA-2hq4A:
undetectable
4z4fA-2hq4A:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjf L-LYSINE EPSILON
AMINOTRANSFERASE


(Mycobacterium
tuberculosis)
PF00202
(Aminotran_3)
4 LEU A 335
LYS A  92
PRO A  93
GLU A 126
None
0.93A 4z4fA-2jjfA:
2.8
4z4fA-2jjfA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mbm TOP7 FOLD PROTEIN
TOP7M13


(synthetic
construct)
no annotation 4 LEU A  25
TYR A  26
LEU A  33
GLU A  32
None
0.83A 4z4fA-2mbmA:
undetectable
4z4fA-2mbmA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mf4 HYBRID POLYKETIDE
SYNTHASE-NON
RIBOSOMAL PEPTIDE
SYNTHETASE


(Streptomyces
virginiae)
PF00550
(PP-binding)
4 LEU A6750
TYR A6751
LEU A6772
GLU A6775
None
1.02A 4z4fA-2mf4A:
2.1
4z4fA-2mf4A:
8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qae DIHYDROLIPOYL
DEHYDROGENASE


(Trypanosoma
cruzi)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
4 LEU A 168
PRO A  48
LEU A 189
GLU A 188
None
1.03A 4z4fA-2qaeA:
undetectable
4z4fA-2qaeA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v4j SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA
SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT GAMMA


(Desulfovibrio
vulgaris;
Desulfovibrio
vulgaris)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr)
PF04358
(DsrC)
4 LEU C  53
TYR C  56
LEU C  98
GLU B 223
None
1.02A 4z4fA-2v4jC:
undetectable
4z4fA-2v4jC:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E


(Bacteroides
thetaiotaomicron)
PF07971
(Glyco_hydro_92)
4 LEU A 372
TYR A 376
PRO A 383
LEU A 403
None
0.85A 4z4fA-2wzsA:
undetectable
4z4fA-2wzsA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x1i 4-ALPHA-GLUCANOTRANS
FERASE


(Thermus
brockianus)
PF02446
(Glyco_hydro_77)
4 LEU A 438
PRO A 378
LEU A 418
TYR A 417
None
0.92A 4z4fA-2x1iA:
undetectable
4z4fA-2x1iA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z3k LEUCYL/PHENYLALANYL-
TRNA-PROTEIN
TRANSFERASE


(Escherichia
coli)
PF03588
(Leu_Phe_trans)
4 LEU A  38
PRO A  48
LEU A 123
TYR A 120
None
0.98A 4z4fA-2z3kA:
undetectable
4z4fA-2z3kA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zc0 ALANINE GLYOXYLATE
TRANSAMINASE


(Thermococcus
litoralis)
PF00155
(Aminotran_1_2)
4 LYS A 330
PRO A 331
LEU A 319
GLU A 320
None
0.80A 4z4fA-2zc0A:
2.3
4z4fA-2zc0A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3adr PUTATIVE
UNCHARACTERIZED
PROTEIN ST1585


(Sulfurisphaera
tokodaii)
PF00753
(Lactamase_B)
4 LEU A 142
TYR A 144
LYS A  81
GLU A 128
None
1.07A 4z4fA-3adrA:
undetectable
4z4fA-3adrA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvd PLASTOCYANIN

(Phormidium
laminosum)
PF00127
(Copper-bind)
4 LEU A  55
PRO A  81
LEU A  59
TYR A  85
None
1.06A 4z4fA-3cvdA:
undetectable
4z4fA-3cvdA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ffr PHOSPHOSERINE
AMINOTRANSFERASE
SERC


(Cytophaga
hutchinsonii)
PF00266
(Aminotran_5)
4 LEU A 171
PRO A 174
LEU A  55
GLU A  56
None
1.02A 4z4fA-3ffrA:
undetectable
4z4fA-3ffrA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgt PUTATIVE
PHOSPHOLIPASE B-LIKE
2 40 KDA FORM


(Mus musculus)
PF04916
(Phospholip_B)
4 LEU B 255
TYR B 427
LEU B 422
GLU B 421
None
0.98A 4z4fA-3fgtB:
undetectable
4z4fA-3fgtB:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3glq ADENOSYLHOMOCYSTEINA
SE


(Burkholderia
pseudomallei)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
4 TYR A 425
LEU A 207
GLU A 211
TYR A 208
None
1.04A 4z4fA-3glqA:
undetectable
4z4fA-3glqA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h11 CASP8 AND FADD-LIKE
APOPTOSIS REGULATOR


(Homo sapiens)
PF00656
(Peptidase_C14)
4 LEU A 477
TYR A 479
LEU A 274
TYR A 276
None
1.07A 4z4fA-3h11A:
4.2
4z4fA-3h11A:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jr7 UNCHARACTERIZED EGV
FAMILY PROTEIN
COG1307


([Ruminococcus]
gnavus)
PF02645
(DegV)
4 LEU A 183
LYS A 206
PRO A 207
GLU A 181
None
0.79A 4z4fA-3jr7A:
undetectable
4z4fA-3jr7A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lad DIHYDROLIPOAMIDE
DEHYDROGENASE


(Azotobacter
vinelandii)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
4 LEU A 174
PRO A  55
LEU A 195
GLU A 194
None
0.98A 4z4fA-3ladA:
undetectable
4z4fA-3ladA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldr FRUCTOSYLTRANSFERASE

(Aspergillus
japonicus)
PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C)
4 PRO A  28
LEU A 534
GLU A 535
TYR A 619
None
1.05A 4z4fA-3ldrA:
undetectable
4z4fA-3ldrA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lwu SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE


(Shewanella
frigidimarina)
PF04952
(AstE_AspA)
4 LEU A 288
TYR A 287
PRO A 204
LEU A 201
None
0.91A 4z4fA-3lwuA:
2.1
4z4fA-3lwuA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwc MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN


(Kosmotoga
olearia)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 LEU A 249
PRO A 237
LEU A 217
GLU A 216
None
0.79A 4z4fA-3mwcA:
undetectable
4z4fA-3mwcA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oad RENIN

(Homo sapiens)
PF00026
(Asp)
4 LEU B 246
PRO B 266
LEU B 298
TYR B 284
None
0.68A 4z4fA-3oadB:
undetectable
4z4fA-3oadB:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p4e PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE


(Vibrio cholerae)
PF00586
(AIRS)
PF02769
(AIRS_C)
4 LEU A 222
PRO A 190
LEU A  74
TYR A 195
None
1.01A 4z4fA-3p4eA:
undetectable
4z4fA-3p4eA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qr1 PHOSPHOLIPASE C-BETA
(PLC-BETA)


(Doryteuthis
pealeii)
PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like)
4 LEU A 303
TYR A 304
LEU A 223
TYR A 222
None
0.81A 4z4fA-3qr1A:
undetectable
4z4fA-3qr1A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT M


(Escherichia
coli)
no annotation 4 LEU M 244
LYS M 234
PRO M 236
LEU M 259
None
0.98A 4z4fA-3rkoM:
undetectable
4z4fA-3rkoM:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tad LIPRIN-ALPHA-2

(Homo sapiens)
PF00536
(SAM_1)
PF07647
(SAM_2)
4 LEU A 909
TYR A1016
LEU A 885
GLU A 886
None
0.89A 4z4fA-3tadA:
undetectable
4z4fA-3tadA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tl2 MALATE DEHYDROGENASE

(Bacillus
anthracis)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
4 LEU A 177
PRO A 273
LEU A 297
TYR A 263
None
1.01A 4z4fA-3tl2A:
2.4
4z4fA-3tl2A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tos CALS11

(Micromonospora
echinospora)
PF05711
(TylF)
4 TYR A 193
PRO A 195
LEU A 200
GLU A 201
None
SAH  A 258 (-4.1A)
None
None
0.99A 4z4fA-3tosA:
undetectable
4z4fA-3tosA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3urh DIHYDROLIPOYL
DEHYDROGENASE


(Sinorhizobium
meliloti)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
4 LEU A 169
PRO A  48
LEU A 190
GLU A 189
None
None
None
FAD  A 500 ( 4.5A)
1.07A 4z4fA-3urhA:
undetectable
4z4fA-3urhA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wg6 CONJUGATED
POLYKETONE REDUCTASE
C1


(Candida
parapsilosis)
PF00248
(Aldo_ket_red)
4 LEU A 145
TYR A 104
PRO A 103
TYR A 122
None
1.06A 4z4fA-3wg6A:
undetectable
4z4fA-3wg6A:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zzf ACETYLGLUTAMATE
KINASE


(Saccharomyces
cerevisiae)
PF00696
(AA_kinase)
4 LEU A 120
TYR A 124
PRO A 130
LEU A 183
None
0.99A 4z4fA-3zzfA:
undetectable
4z4fA-3zzfA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zzi ACETYLGLUTAMATE
KINASE


(Saccharomyces
cerevisiae)
PF00696
(AA_kinase)
PF04768
(NAT)
4 LEU A 120
TYR A 124
PRO A 130
LEU A 183
None
1.04A 4z4fA-3zziA:
3.4
4z4fA-3zziA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4as3 PHOSPHORYLCHOLINE
PHOSPHATASE


(Pseudomonas
aeruginosa)
no annotation 4 LEU A  60
LEU A  79
GLU A  77
TYR A  82
None
1.01A 4z4fA-4as3A:
2.3
4z4fA-4as3A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e2o ALPHA-AMYLASE

(Geobacillus
thermoleovorans)
PF00128
(Alpha-amylase)
4 LEU A 476
PRO A 441
LEU A 446
TYR A 462
None
1.01A 4z4fA-4e2oA:
2.0
4z4fA-4e2oA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eq5 DNA LIGASE

(Thermococcus
sibiricus)
PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C)
4 LEU A 405
PRO A 435
GLU A 398
TYR A 401
None
0.89A 4z4fA-4eq5A:
undetectable
4z4fA-4eq5A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4erc DUAL SPECIFICITY
PROTEIN PHOSPHATASE
23


(Homo sapiens)
PF00782
(DSPc)
4 LEU A  39
PRO A  47
LEU A  56
TYR A  28
None
1.06A 4z4fA-4ercA:
2.6
4z4fA-4ercA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f1n KPAGO

(Vanderwaltozyma
polyspora)
PF02171
(Piwi)
4 LEU A1026
PRO A1038
LEU A1075
TYR A1081
None
1.00A 4z4fA-4f1nA:
36.9
4z4fA-4f1nA:
27.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fek PUTATIVE DIFLAVIN
FLAVOPROTEIN A 5


(Nostoc sp. PCC
7120)
no annotation 4 LEU A  99
PRO A  58
LEU A  68
TYR A  67
None
0.88A 4z4fA-4fekA:
undetectable
4z4fA-4fekA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3a CLIP-ASSOCIATING
PROTEIN


(Drosophila
melanogaster)
PF12348
(CLASP_N)
4 LEU A 192
TYR A 196
LEU A 221
GLU A 222
None
0.98A 4z4fA-4g3aA:
undetectable
4z4fA-4g3aA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gn2 OXACILLINASE

(Pseudomonas
aeruginosa)
PF00905
(Transpeptidase)
4 LEU A  79
PRO A 105
LEU A 120
TYR A 116
None
0.99A 4z4fA-4gn2A:
undetectable
4z4fA-4gn2A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4guz PROBABLE ARYLAMINE
N-ACETYL TRANSFERASE


(Mycobacteroides
abscessus)
PF00797
(Acetyltransf_2)
4 LEU A  29
PRO A 135
LEU A 117
GLU A 120
None
0.83A 4z4fA-4guzA:
undetectable
4z4fA-4guzA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ikh GLUTATHIONE
S-TRANSFERASE


(Pseudomonas
protegens)
PF00043
(GST_C)
PF02798
(GST_N)
4 LEU A  23
PRO A 231
LEU A  38
GLU A  39
None
0.96A 4z4fA-4ikhA:
undetectable
4z4fA-4ikhA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4js5 EXODEOXYRIBONUCLEASE
I


(Escherichia
coli)
PF00929
(RNase_T)
PF08411
(Exonuc_X-T_C)
4 LEU A 467
PRO A  59
LEU A 447
GLU A 446
None
0.99A 4z4fA-4js5A:
undetectable
4z4fA-4js5A:
20.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4krf PROTEIN ARGONAUTE-1

(Homo sapiens)
PF02170
(PAZ)
PF02171
(Piwi)
PF08699
(ArgoL1)
PF16486
(ArgoN)
PF16487
(ArgoMid)
PF16488
(ArgoL2)
5 LEU A 648
TYR A 652
PRO A 659
LEU A 692
TYR A 696
None
0.35A 4z4fA-4krfA:
61.7
4z4fA-4krfA:
82.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lcc BETA-2-MICROGLOBULIN
, MHC CLASS
I-RELATED PROTEIN


(Bos taurus)
PF00129
(MHC_I)
PF07654
(C1-set)
4 LEU C  64
TYR C  28
PRO C 345
TYR C  10
None
0.90A 4z4fA-4lccC:
undetectable
4z4fA-4lccC:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mf6 GLUTATHIONE
S-TRANSFERASE DOMAIN


(Paraburkholderia
graminis)
PF00043
(GST_C)
PF02798
(GST_N)
4 LEU A  23
PRO A 231
LEU A  38
GLU A  39
None
0.78A 4z4fA-4mf6A:
undetectable
4z4fA-4mf6A:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1


(Homo sapiens)
PF05994
(FragX_IP)
PF07159
(DUF1394)
5 LEU A 852
TYR A 855
PRO A 853
LEU A 847
GLU A 846
None
1.47A 4z4fA-4n78A:
undetectable
4z4fA-4n78A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nax GLUTATHIONE
S-TRANSFERASE,
N-TERMINAL DOMAIN
PROTEIN


(Pseudomonas
putida)
PF00043
(GST_C)
PF02798
(GST_N)
4 LEU A  23
PRO A 230
LEU A  38
GLU A  39
None
0.90A 4z4fA-4naxA:
undetectable
4z4fA-4naxA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nhz PUTATIVE GLUTATHIONE
S-TRANSFERASE ENZYME
WITH
THIOREDOXIN-LIKE
DOMAIN


(Bradyrhizobium
sp. BTAi1)
PF00043
(GST_C)
PF02798
(GST_N)
4 LEU A  23
PRO A 231
LEU A  38
GLU A  39
None
0.90A 4z4fA-4nhzA:
undetectable
4z4fA-4nhzA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pmn TAT-SECRETED PROTEIN
RV2525C


(Mycobacterium
tuberculosis)
PF08924
(DUF1906)
4 LEU A 127
TYR A  65
LYS A  79
PRO A  80
GOL  A 302 (-4.9A)
None
MES  A 301 (-2.7A)
None
1.05A 4z4fA-4pmnA:
undetectable
4z4fA-4pmnA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pmr TAT-SECRETED PROTEIN
RV2525C


(Mycobacterium
tuberculosis)
PF08924
(DUF1906)
4 LEU A 127
TYR A  65
LYS A  79
PRO A  80
None
None
EPE  A 301 (-2.8A)
None
1.05A 4z4fA-4pmrA:
2.4
4z4fA-4pmrA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u7l LEUCINE-RICH REPEATS
AND
IMMUNOGLOBULIN-LIKE
DOMAINS PROTEIN 1


(Homo sapiens)
PF01463
(LRRCT)
PF13855
(LRR_8)
4 LEU A  80
PRO A  68
LEU A 101
TYR A  98
None
0.97A 4z4fA-4u7lA:
undetectable
4z4fA-4u7lA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u8h CRYPTOCHROME-2

(Mus musculus)
PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7)
4 LEU A 290
TYR A 291
LYS A 295
GLU A 253
None
1.04A 4z4fA-4u8hA:
2.9
4z4fA-4u8hA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xdy KETOL-ACID
REDUCTOISOMERASE


(uncultured
archaeon
GZfos26G2)
PF01450
(IlvC)
PF07991
(IlvN)
4 LEU A 102
PRO A 124
GLU A  95
TYR A  94
None
0.99A 4z4fA-4xdyA:
undetectable
4z4fA-4xdyA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zyj DNMZ

(Streptomyces
peucetius)
PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
4 LEU A  88
LYS A  22
PRO A  21
LEU A  18
None
0.97A 4z4fA-4zyjA:
undetectable
4z4fA-4zyjA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a4j FORMATE--TETRAHYDROF
OLATE LIGASE


(Tepidanaerobacter
acetatoxydans)
PF01268
(FTHFS)
4 TYR A  44
LYS A 255
PRO A 256
GLU A  33
EDO  A1562 (-4.5A)
EDO  A1562 (-3.2A)
None
None
0.70A 4z4fA-5a4jA:
6.5
4z4fA-5a4jA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cs0 ACETYL-COA
CARBOXYLASE


(Saccharomyces
cerevisiae)
PF08326
(ACC_central)
4 LEU A 838
TYR A 840
LEU A 918
TYR A 914
None
0.95A 4z4fA-5cs0A:
undetectable
4z4fA-5cs0A:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csa ACETYL-COA
CARBOXYLASE


(Saccharomyces
cerevisiae)
PF00364
(Biotin_lipoyl)
PF08326
(ACC_central)
4 LEU A 838
TYR A 840
LEU A 918
TYR A 914
None
1.04A 4z4fA-5csaA:
2.3
4z4fA-5csaA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csl ACETYL-COA
CARBOXYLASE


(Saccharomyces
cerevisiae)
PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
PF08326
(ACC_central)
4 LEU A 838
TYR A 840
LEU A 918
TYR A 914
None
1.06A 4z4fA-5cslA:
3.4
4z4fA-5cslA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gnb SPIKE GLYCOPROTEIN

(Human
coronavirus
HKU1)
PF09408
(Spike_rec_bind)
4 LEU A 409
TYR A 414
PRO A 341
LEU A 401
None
1.05A 4z4fA-5gnbA:
undetectable
4z4fA-5gnbA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gvs PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX41


(Homo sapiens)
PF00270
(DEAD)
4 LEU A 284
PRO A 189
LEU A 244
GLU A 245
None
0.91A 4z4fA-5gvsA:
undetectable
4z4fA-5gvsA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h67 CHROMOSOME PARTITION
PROTEIN SMC
CHROMOSOME PARTITION
PROTEIN SMC


(Bacillus
subtilis;
Bacillus
subtilis)
PF02463
(SMC_N)
PF02463
(SMC_N)
4 LEU B1004
LYS B 999
LEU A 195
GLU A 199
None
0.94A 4z4fA-5h67B:
undetectable
4z4fA-5h67B:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikz OXALATE BIOSYNTHETIC
COMPONENT 1


(Burkholderia
thailandensis)
PF05853
(BKACE)
4 LEU A 729
LYS A 680
PRO A 681
GLU A 688
None
0.75A 4z4fA-5ikzA:
undetectable
4z4fA-5ikzA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6q CELL WALL BINDING
PROTEIN CWP8


(Clostridioides
difficile)
PF04122
(CW_binding_2)
4 LEU A 223
TYR A 221
LYS A 216
GLU A 261
None
0.90A 4z4fA-5j6qA:
undetectable
4z4fA-5j6qA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxm PRIB

(Streptomyces
sp. RM-5-8)
PF11991
(Trp_DMAT)
4 LEU A  35
PRO A  81
LEU A  76
TYR A 386
None
0.99A 4z4fA-5jxmA:
undetectable
4z4fA-5jxmA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k04 UNCHARACTERIZED
PROTEIN


(Candida
albicans)
PF09797
(NatB_MDM20)
4 LEU A 406
TYR A 404
LEU A 372
GLU A 369
None
1.02A 4z4fA-5k04A:
undetectable
4z4fA-5k04A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tr3 DIHYDROLIPOYL
DEHYDROGENASE


(Pseudomonas
putida)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
4 LEU A 175
PRO A  56
LEU A 196
GLU A 195
None
None
None
FAD  A 501 ( 4.6A)
1.04A 4z4fA-5tr3A:
undetectable
4z4fA-5tr3A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v0i TRYPTOPHAN--TRNA
LIGASE


(Escherichia
coli)
PF00579
(tRNA-synt_1b)
4 LEU A  16
TYR A  21
LEU A  66
TYR A  67
None
0.56A 4z4fA-5v0iA:
undetectable
4z4fA-5v0iA:
17.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vm9 PROTEIN ARGONAUTE-3

(Homo sapiens)
no annotation 7 LEU A 651
TYR A 655
LYS A 661
PRO A 662
LEU A 695
GLU A 696
TYR A 699
None
0.81A 4z4fA-5vm9A:
58.0
4z4fA-5vm9A:
79.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wea PROTEIN ARGONAUTE-2

(Homo sapiens)
no annotation 6 LEU A 650
LYS A 660
PRO A 661
LEU A 694
GLU A 695
TYR A 698
IPH  A 901 (-4.7A)
None
None
IPH  A 901 (-3.9A)
IPH  A 901 (-3.6A)
IPH  A 901 ( 4.9A)
0.91A 4z4fA-5weaA:
57.4
4z4fA-5weaA:
99.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wea PROTEIN ARGONAUTE-2

(Homo sapiens)
no annotation 6 LEU A 650
TYR A 654
PRO A 661
LEU A 694
GLU A 695
TYR A 698
IPH  A 901 (-4.7A)
None
None
IPH  A 901 (-3.9A)
IPH  A 901 (-3.6A)
IPH  A 901 ( 4.9A)
0.65A 4z4fA-5weaA:
57.4
4z4fA-5weaA:
99.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x1y MERCURIC REDUCTASE

(Lysinibacillus
sphaericus)
no annotation 4 LEU B 243
PRO B 129
LEU B 264
GLU B 263
None
None
FAD  B 601 ( 4.9A)
FAD  B 601 ( 4.5A)
1.01A 4z4fA-5x1yB:
undetectable
4z4fA-5x1yB:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x62 CARNOSINE
N-METHYLTRANSFERASE


(Saccharomyces
cerevisiae)
PF07942
(N2227)
4 LEU A 368
TYR A 385
PRO A 383
GLU A 120
None
0.88A 4z4fA-5x62A:
undetectable
4z4fA-5x62A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bz0 DIHYDROLIPOYL
DEHYDROGENASE


(Acinetobacter
baumannii)
no annotation 4 LEU A 174
PRO A  55
LEU A 195
GLU A 194
None
None
None
FAD  A 501 ( 4.5A)
1.03A 4z4fA-6bz0A:
undetectable
4z4fA-6bz0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER


(Enterococcus
casseliflavus)
no annotation 4 LEU A 145
LYS A 140
LEU A  17
GLU A  13
None
None
DMU  A 501 ( 4.8A)
None
1.02A 4z4fA-6d0nA:
undetectable
4z4fA-6d0nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dfu TRYPTOPHAN--TRNA
LIGASE


(Haemophilus
influenzae)
no annotation 4 LEU A  16
TYR A  21
LEU A  66
TYR A  67
None
0.68A 4z4fA-6dfuA:
undetectable
4z4fA-6dfuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdt -

(-)
no annotation 4 TYR A 349
LYS A 351
LEU A 379
GLU A 380
None
0.95A 4z4fA-6fdtA:
undetectable
4z4fA-6fdtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fgk GTP
PYROPHOSPHOKINASE
YWAC


(Bacillus
subtilis)
no annotation 4 LEU A 134
TYR A 122
LYS A 120
GLU A 154
None
0.78A 4z4fA-6fgkA:
undetectable
4z4fA-6fgkA:
undetectable