SIMILAR PATTERNS OF AMINO ACIDS FOR 4Z4E_A_IPHA906_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a8q BROMOPEROXIDASE A1

(Kitasatospora
aureofaciens) 		PF00561
(Abhydrolase_1) 		4 PHE A 211
PRO A 214
ALA A 242
PHE A 271
 None
 1.25A 4z4eA-1a8qA:
undetectable		 4z4eA-1a8qA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1brt BROMOPEROXIDASE A2

(Kitasatospora
aureofaciens) 		PF00561
(Abhydrolase_1) 		4 PRO A 219
VAL A 119
ALA A 247
PHE A 274
 None
 1.13A 4z4eA-1brtA:
undetectable		 4z4eA-1brtA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eyw PHOSPHOTRIESTERASE

(Brevundimonas
diminuta) 		PF02126
(PTE) 		4 PHE A 216
PRO A 223
VAL A 226
ALA A 213
 None
 1.05A 4z4eA-1eywA:
undetectable		 4z4eA-1eywA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fft UBIQUINOL OXIDASE

(Escherichia
coli) 		PF00116
(COX2)
PF06481
(COX_ARM) 		4 PHE B 155
PRO B 160
VAL B 161
ALA B 197
 None
 1.03A 4z4eA-1fftB:
undetectable		 4z4eA-1fftB:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h79 ANAEROBIC
RIBONUCLEOTIDE-TRIPH
OSPHATE REDUCTASE
LARGE CHAIN

(Escherichia
virus T4) 		PF13597
(NRDD) 		4 PRO A 287
VAL A 285
ALA A 130
PHE A 237
 None
 0.96A 4z4eA-1h79A:
3.4		 4z4eA-1h79A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mpp PEPSIN

(Rhizomucor
pusillus) 		PF00026
(Asp) 		4 PHE A 212
PRO A 193
VAL A 194
ALA A 211
 None
 1.14A 4z4eA-1mppA:
undetectable		 4z4eA-1mppA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o8p PUTATUVE
ENDO-XYLANASE

([Clostridium]
stercorarium) 		PF03422
(CBM_6) 		4 PHE A 135
PRO A 138
VAL A 139
PHE A 112
 None
 1.12A 4z4eA-1o8pA:
undetectable		 4z4eA-1o8pA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oru YUAD PROTEIN

(Bacillus
subtilis) 		no annotation 4 PHE A  30
PRO A 167
VAL A 164
ALA A 118
 None
 1.31A 4z4eA-1oruA:
undetectable		 4z4eA-1oruA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ozh ACETOLACTATE
SYNTHASE, CATABOLIC

(Klebsiella
pneumoniae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 PHE A 256
PRO A 237
VAL A 238
ALA A 257
 PO4  A1404 (-4.7A)
None
None
None
 1.07A 4z4eA-1ozhA:
4.3		 4z4eA-1ozhA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t0h VOLTAGE-GATED
CALCIUM CHANNEL
SUBUNIT BETA2A
VOLTAGE-GATED
CALCIUM CHANNEL
SUBUNIT BETA2A

(Rattus
norvegicus;
Rattus
norvegicus) 		PF12052
(VGCC_beta4Aa_N)
PF00625
(Guanylate_kin) 		4 PHE A  62
PRO B 224
VAL B 222
ALA A  63
 None
 1.31A 4z4eA-1t0hA:
undetectable		 4z4eA-1t0hA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vyt CALCIUM CHANNEL
BETA-3 SUBUNIT

(Rattus
norvegicus) 		PF00625
(Guanylate_kin)
PF12052
(VGCC_beta4Aa_N) 		4 PHE A  62
PRO A 175
VAL A 173
ALA A  63
 None
 1.28A 4z4eA-1vytA:
undetectable		 4z4eA-1vytA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w36 EXODEOXYRIBONUCLEASE
V GAMMA CHAIN

(Escherichia
coli) 		PF04257
(Exonuc_V_gamma) 		4 PHE C 526
PRO C 549
VAL C 547
ALA C 904
 None
 1.28A 4z4eA-1w36C:
1.9		 4z4eA-1w36C:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wfy REGULATOR OF
G-PROTEIN SIGNALING
14
RAP1/RAP2
INTERACTING PROTEIN

(Mus musculus) 		PF02196
(RBD) 		4 PHE A  19
PRO A  36
VAL A  75
ALA A  79
 None
 1.32A 4z4eA-1wfyA:
undetectable		 4z4eA-1wfyA:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y07 DESULFOFERRODOXIN
(RBO)

(Treponema
pallidum) 		PF01880
(Desulfoferrodox) 		4 PHE A   7
PRO A  39
VAL A  40
ALA A  37
 None
 1.32A 4z4eA-1y07A:
undetectable		 4z4eA-1y07A:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zoi ESTERASE

(Pseudomonas
putida) 		PF00561
(Abhydrolase_1) 		4 PRO A 218
VAL A 219
ALA A 247
PHE A 273
 None
 1.00A 4z4eA-1zoiA:
2.9		 4z4eA-1zoiA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cdq ASPARTOKINASE

(Arabidopsis
thaliana) 		PF00696
(AA_kinase) 		4 PHE A 483
PRO A 271
VAL A 272
ALA A 269
 None
 1.33A 4z4eA-2cdqA:
undetectable		 4z4eA-2cdqA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d57 AQUAPORIN-4

(Rattus
norvegicus) 		PF00230
(MIP) 		4 PHE A 218
PRO A 220
VAL A 222
ALA A 126
 None
 1.27A 4z4eA-2d57A:
undetectable		 4z4eA-2d57A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dsj PYRIMIDINE-NUCLEOSID
E (THYMIDINE)
PHOSPHORYLASE

(Thermus
thermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		4 PHE A 105
PRO A  77
VAL A  78
ALA A 106
 None
 1.26A 4z4eA-2dsjA:
undetectable		 4z4eA-2dsjA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2huf ALANINE GLYOXYLATE
AMINOTRANSFERASE

(Aedes aegypti) 		PF00266
(Aminotran_5) 		4 PHE A  73
PRO A 216
VAL A 217
PHE A  65
 None
 1.02A 4z4eA-2hufA:
undetectable		 4z4eA-2hufA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6d RNA
METHYLTRANSFERASE,
TRMH FAMILY

(Porphyromonas
gingivalis) 		PF00588
(SpoU_methylase) 		4 PHE A  25
PRO A 141
VAL A 144
ALA A  26
 None
 1.00A 4z4eA-2i6dA:
undetectable		 4z4eA-2i6dA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ij0 PENULTIMATE
AFFINITY-MATURED
VARIANT OF HVBETA
2.1, D10

(Homo sapiens) 		no annotation 4 PHE E 108
PRO E 110
VAL E  91
PHE E  89
 None
 1.33A 4z4eA-2ij0E:
undetectable		 4z4eA-2ij0E:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inc TOUB PROTEIN

(Pseudomonas
stutzeri) 		PF06234
(TmoB) 		4 PRO C  45
VAL C  43
ALA C  35
PHE C  83
 None
 1.33A 4z4eA-2incC:
undetectable		 4z4eA-2incC:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogj DIHYDROOROTASE

(Agrobacterium
fabrum) 		PF01979
(Amidohydro_1) 		4 PHE A 352
PRO A  24
VAL A  25
PHE A  27
 None
 1.22A 4z4eA-2ogjA:
undetectable		 4z4eA-2ogjA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0u STILBENECARBOXYLATE
SYNTHASE 2

(Marchantia
polymorpha) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 PHE A 342
PRO A 322
VAL A 320
PHE A 391
 None
 1.15A 4z4eA-2p0uA:
undetectable		 4z4eA-2p0uA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ps3 HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA

(Escherichia
coli) 		PF01297
(ZnuA) 		4 PHE A 259
PRO A 261
VAL A 263
ALA A 255
 None
 1.29A 4z4eA-2ps3A:
undetectable		 4z4eA-2ps3A:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qp4 BILE SALT
SULFOTRANSFERASE

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		4 PHE A 109
VAL A 116
ALA A 114
PHE A 201
 None
 1.34A 4z4eA-2qp4A:
3.0		 4z4eA-2qp4A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2quq CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
B

(Saccharomyces
cerevisiae) 		PF16846
(Cep3) 		4 PHE A 401
PRO A 457
VAL A 459
PHE A 500
 None
 1.32A 4z4eA-2quqA:
undetectable		 4z4eA-2quqA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rmp MUCOROPEPSIN

(Rhizomucor
miehei) 		PF00026
(Asp) 		4 PHE A 234
PRO A 214
VAL A 215
ALA A 233
 None
 1.12A 4z4eA-2rmpA:
undetectable		 4z4eA-2rmpA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wl3 CATECHOL
2,3-DIOXYGENASE

(Rhodococcus sp.
DK17) 		PF00903
(Glyoxalase) 		4 PHE A 201
PRO A 187
VAL A 188
ALA A 200
 None
 0.91A 4z4eA-2wl3A:
undetectable		 4z4eA-2wl3A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xua 3-OXOADIPATE
ENOL-LACTONASE

(Paraburkholderia
xenovorans) 		PF12146
(Hydrolase_4) 		4 PRO A 208
VAL A 120
ALA A 235
PHE A 261
 None
 1.09A 4z4eA-2xuaA:
3.7		 4z4eA-2xuaA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y4f PEROXIDASE YCDB

(Escherichia
coli) 		PF04261
(Dyp_perox) 		4 PHE A  42
VAL A 142
ALA A  41
PHE A 368
 None
 1.17A 4z4eA-2y4fA:
undetectable		 4z4eA-2y4fA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yn9 POTASSIUM-TRANSPORTI
NG ATPASE ALPHA
CHAIN 1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF09040
(H-K_ATPase_N)
PF13246
(Cation_ATPase) 		4 PHE A 872
PRO A 794
ALA A 873
PHE A 931
 None
 1.26A 4z4eA-2yn9A:
undetectable		 4z4eA-2yn9A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ypq PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE AROG

(Mycobacterium
tuberculosis) 		PF01474
(DAHP_synth_2) 		4 PHE A  80
PRO A 120
VAL A 121
ALA A 117
 None
 1.11A 4z4eA-2ypqA:
undetectable		 4z4eA-2ypqA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zec TRYPTASE BETA 2

(Homo sapiens) 		PF00089
(Trypsin) 		4 PHE A  98
PRO A  96
VAL A  94
ALA A 105
 None
 0.90A 4z4eA-2zecA:
undetectable		 4z4eA-2zecA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3at7 ALGINATE-BINDING
FLAGELLIN

(Sphingomonas
sp. A1) 		PF09375
(Peptidase_M75) 		4 PHE A 153
PRO A 155
VAL A 158
PHE A 203
 None
 1.05A 4z4eA-3at7A:
undetectable		 4z4eA-3at7A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fob BROMOPEROXIDASE

(Bacillus
anthracis) 		PF00561
(Abhydrolase_1) 		4 PHE A 217
PRO A 220
VAL A 120
PHE A 275
 None
 1.26A 4z4eA-3fobA:
3.2		 4z4eA-3fobA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gd8 AQUAPORIN-4

(Homo sapiens) 		PF00230
(MIP) 		4 PHE A 218
PRO A 220
VAL A 222
ALA A 126
 None
 1.32A 4z4eA-3gd8A:
undetectable		 4z4eA-3gd8A:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hv9 PROTEIN FIMX

(Pseudomonas
aeruginosa) 		PF00563
(EAL) 		4 PHE A 531
PRO A 462
VAL A 463
PHE A 686
 None
 0.87A 4z4eA-3hv9A:
undetectable		 4z4eA-3hv9A:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 3

(Thermus
thermophilus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4)
PF10588
(NADH-G_4Fe-4S_3)
PF13510
(Fer2_4) 		4 PHE 3 382
PRO 3 384
VAL 3 532
ALA 3 379
 None
 1.21A 4z4eA-3i9v3:
2.7		 4z4eA-3i9v3:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7y ML43

(Homo sapiens) 		no annotation 4 PHE b  54
PRO b  59
VAL b  61
ALA b  55
 None
 1.32A 4z4eA-3j7yb:
undetectable		 4z4eA-3j7yb:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jq1 SUSD SUPERFAMILY
PROTEIN

(Bacteroides
vulgatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 PHE A  82
PRO A 311
VAL A  80
PHE A 450
 None
 1.21A 4z4eA-3jq1A:
undetectable		 4z4eA-3jq1A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lah METHYL-ACCEPTING
CHEMOTAXIS PROTEIN

(Caldanaerobacter
subterraneus) 		PF07700
(HNOB) 		4 PHE A 178
PRO A 181
VAL A 182
ALA A 126
 None
 0.86A 4z4eA-3lahA:
undetectable		 4z4eA-3lahA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lw2 PLASMINOGEN
ACTIVATOR INHIBITOR
1

(Mus musculus) 		PF00079
(Serpin) 		4 PHE A  15
PRO A  36
VAL A  39
ALA A  12
 None
 1.31A 4z4eA-3lw2A:
undetectable		 4z4eA-3lw2A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lwx NADH:UBIQUINONE
OXIDOREDUCTASE, NA
TRANSLOCATING, C
SUBUNIT

(Parabacteroides
distasonis) 		PF04205
(FMN_bind) 		4 PHE A 116
PRO A 144
VAL A 145
ALA A 115
 None
 1.05A 4z4eA-3lwxA:
undetectable		 4z4eA-3lwxA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0l SERINE
HYDROXYMETHYLTRANSFE
RASE

(Campylobacter
jejuni) 		PF00464
(SHMT) 		4 PHE A 193
VAL A 217
ALA A 194
PHE A 212
 None
 1.16A 4z4eA-3n0lA:
undetectable		 4z4eA-3n0lA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nja PROBABLE GGDEF
FAMILY PROTEIN

(Chromobacterium
violaceum) 		PF08447
(PAS_3) 		4 PHE A  52
PRO A  57
VAL A  55
ALA A  61
 None
 1.31A 4z4eA-3njaA:
undetectable		 4z4eA-3njaA:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o7w LEUCINE CARBOXYL
METHYLTRANSFERASE 1

(Homo sapiens) 		PF04072
(LCM) 		4 PHE A 220
PRO A 192
ALA A 223
PHE A  84
 None
 1.02A 4z4eA-3o7wA:
2.1		 4z4eA-3o7wA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oit OS07G0271500 PROTEIN

(Oryza sativa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 PHE A 384
PRO A 317
VAL A 315
ALA A 383
 None
 1.32A 4z4eA-3oitA:
undetectable		 4z4eA-3oitA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oxh RV0577 PROTEIN

(Mycobacterium
tuberculosis) 		PF00903
(Glyoxalase) 		4 PHE A 160
PRO A  95
VAL A  93
ALA A 163
 None
 1.32A 4z4eA-3oxhA:
undetectable		 4z4eA-3oxhA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p77 MHC RFP-Y CLASS I
ALPHA CHAIN

(Gallus gallus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 PHE A 119
PRO A 134
VAL A 135
ALA A 131
 PGE  A 278 ( 4.7A)
None
None
None
 1.32A 4z4eA-3p77A:
undetectable		 4z4eA-3p77A:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppx VON WILLEBRAND
FACTOR

(Homo sapiens) 		PF00092
(VWA) 		4 PHE A1501
VAL A1537
ALA A1500
PHE A1552
 None
 1.29A 4z4eA-3ppxA:
5.5		 4z4eA-3ppxA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfe PUTATIVE
DIHYDRODIPICOLINATE
SYNTHASE FAMILY
PROTEIN

(Coccidioides
immitis) 		PF00701
(DHDPS) 		4 PHE A 192
PRO A 165
VAL A 167
ALA A 191
 None
 1.27A 4z4eA-3qfeA:
undetectable		 4z4eA-3qfeA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfg UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF16729
(DUF5067) 		4 PHE A  69
PRO A 106
ALA A  71
PHE A 159
 None
 1.22A 4z4eA-3qfgA:
undetectable		 4z4eA-3qfgA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s98 INTERFERON
ALPHA/BETA RECEPTOR
1

(Homo sapiens) 		PF01108
(Tissue_fac)
PF09294
(Interfer-bind) 		4 PHE A  96
VAL A  69
ALA A  99
PHE A  62
 None
 1.29A 4z4eA-3s98A:
undetectable		 4z4eA-3s98A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqg METHYL COENZYME M
REDUCTASE, ALPHA
SUBUNIT

(uncultured
archaeon) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		4 PHE A  10
VAL A 410
ALA A  13
PHE A  18
 None
 1.30A 4z4eA-3sqgA:
undetectable		 4z4eA-3sqgA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t05 PYRUVATE KINASE

(Staphylococcus
aureus) 		PF00224
(PK)
PF00391
(PEP-utilizers)
PF02887
(PK_C) 		4 PRO A 272
VAL A 273
ALA A 307
PHE A 217
 None
 1.33A 4z4eA-3t05A:
undetectable		 4z4eA-3t05A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wy2 ALPHA-GLUCOSIDASE

(Halomonas sp.
H11) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		4 PHE A 534
PRO A 512
VAL A 513
ALA A 533
 None
 0.95A 4z4eA-3wy2A:
undetectable		 4z4eA-3wy2A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1j PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF01467
(CTP_transf_like) 		4 PHE A  76
PRO A   7
ALA A  36
PHE A  10
 PO4  A 202 (-4.3A)
ACO  A 201 (-4.5A)
ACO  A 201 (-3.6A)
ACO  A 201 ( 4.5A)
 1.30A 4z4eA-3x1jA:
2.9		 4z4eA-3x1jA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgo EFEM M75 PEPTIDASE

(Pseudomonas
syringae) 		PF09375
(Peptidase_M75) 		4 PHE A 164
PRO A 166
VAL A 169
PHE A 214
 None
 1.01A 4z4eA-4bgoA:
undetectable		 4z4eA-4bgoA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f92 U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		4 PHE B1514
PRO B1516
VAL B1518
ALA B1350
 None
 1.13A 4z4eA-4f92B:
2.2		 4z4eA-4f92B:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifr 2-AMINO-3-CARBOXYMUC
ONATE 6-SEMIALDEHYDE
DECARBOXYLASE

(Pseudomonas
fluorescens) 		PF04909
(Amidohydro_2) 		4 PHE A  13
PRO A  81
VAL A  82
ALA A  79
 None
 1.33A 4z4eA-4ifrA:
undetectable		 4z4eA-4ifrA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iq4 NON-HAEM
BROMOPEROXIDASE
BPO-A2, MATRIX
PROTEIN 1

(Kitasatospora
aureofaciens;
Influenza A
virus) 		PF00561
(Abhydrolase_1)
PF00598
(Flu_M1) 		4 PRO A 219
VAL A 119
ALA A 247
PHE A 274
 None
 1.10A 4z4eA-4iq4A:
3.8		 4z4eA-4iq4A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iyj GDSL-LIKE PROTEIN

(Bacteroides
uniformis) 		PF13472
(Lipase_GDSL_2) 		4 PHE A 151
PRO A 155
VAL A 157
ALA A 150
 None
 1.00A 4z4eA-4iyjA:
4.4		 4z4eA-4iyjA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0e PROBABLE
3-HYDROXYACYL-COA
DEHYDROGENASE
F54C8.1

(Caenorhabditis
elegans) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 PHE A 211
PRO A 274
VAL A 276
ALA A 272
 None
 1.28A 4z4eA-4j0eA:
3.3		 4z4eA-4j0eA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j40 FIMX

(Pseudomonas
aeruginosa) 		PF00563
(EAL) 		4 PHE A 531
PRO A 462
VAL A 463
PHE A 686
 None
 0.78A 4z4eA-4j40A:
undetectable		 4z4eA-4j40A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jkl BETA-GLUCURONIDASE

(Streptococcus
agalactiae) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		4 PHE A  81
VAL A 167
ALA A  88
PHE A  60
 None
 1.06A 4z4eA-4jklA:
2.0		 4z4eA-4jklA:
21.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4krf PROTEIN ARGONAUTE-1

(Homo sapiens) 		PF02170
(PAZ)
PF02171
(Piwi)
PF08699
(ArgoL1)
PF16486
(ArgoN)
PF16487
(ArgoMid)
PF16488
(ArgoL2) 		5 PHE A 585
PRO A 588
VAL A 589
ALA A 618
PHE A 651
 None
 0.23A 4z4eA-4krfA:
59.9		 4z4eA-4krfA:
82.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kws D-MANNONATE
DEHYDRATASE

(Chromohalobacter
salexigens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 PHE A 197
PRO A 232
VAL A 230
ALA A 198
 None
 1.35A 4z4eA-4kwsA:
undetectable		 4z4eA-4kwsA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgq PUTATIVE POLYKETIDE
CYCLASE

(Chromobacterium
violaceum) 		PF07366
(SnoaL) 		4 PHE A  36
PRO A  34
VAL A  32
ALA A 121
 None
 1.16A 4z4eA-4lgqA:
undetectable		 4z4eA-4lgqA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nl4 PRIMOSOME ASSEMBLY
PROTEIN PRIA

(Klebsiella
pneumoniae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 PHE H  16
PRO H   9
VAL H  10
ALA H   7
 None
 1.31A 4z4eA-4nl4H:
2.3		 4z4eA-4nl4H:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rpf HOMOSERINE KINASE

(Yersinia pestis) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 PHE A  44
PRO A  81
ALA A  83
PHE A 113
 None
 1.24A 4z4eA-4rpfA:
undetectable		 4z4eA-4rpfA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tlh ETHANOLAMINE
UTILIZATION PROTEIN
EUTL

(Clostridium
perfringens) 		PF00936
(BMC) 		4 PHE A 176
VAL A 151
ALA A 187
PHE A 203
 None
 0.97A 4z4eA-4tlhA:
undetectable		 4z4eA-4tlhA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zw0 3-HYDROXYACYL-[ACYL-
CARRIER-PROTEIN]
DEHYDRATASE FABZ

(Candidatus
Liberibacter
asiaticus) 		PF07977
(FabA) 		4 PHE A  86
PRO A  92
VAL A 148
ALA A  81
 None
 1.10A 4z4eA-4zw0A:
undetectable		 4z4eA-4zw0A:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zw2 VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
BETA-1,VOLTAGE-DEPEN
DENT L-TYPE CALCIUM
CHANNEL SUBUNIT
BETA-1

(Mus musculus) 		PF00625
(Guanylate_kin)
PF12052
(VGCC_beta4Aa_N) 		4 PHE A  40
PRO A 143
VAL A 141
ALA A  41
 PGE  A 401 ( 3.5A)
None
None
None
 1.30A 4z4eA-4zw2A:
undetectable		 4z4eA-4zw2A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a12 CHLORITE DISMUTASE

(Magnetospirillum
sp.) 		PF06778
(Chlor_dismutase) 		4 PHE A 196
PRO A 148
VAL A 149
ALA A 194
 HEM  A 250 (-3.8A)
None
HEM  A 250 ( 4.4A)
None
 1.09A 4z4eA-5a12A:
undetectable		 4z4eA-5a12A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8b PTAUREO1A LOV2
DOMAIN

(Phaeodactylum
tricornutum) 		PF13426
(PAS_9) 		4 PHE A 241
VAL A 349
ALA A 334
PHE A 331
 None
None
None
FMN  A 500 (-3.7A)
 1.22A 4z4eA-5a8bA:
undetectable		 4z4eA-5a8bA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8z NEUTROPHIL ELASTASE

(Homo sapiens) 		PF00089
(Trypsin) 		4 PHE A 228
PRO A 230
VAL A 181
ALA A 227
 None
 1.25A 4z4eA-5a8zA:
undetectable		 4z4eA-5a8zA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cad SM80.1 VICILIN

(Solanum
melongena) 		PF00190
(Cupin_1) 		4 PHE A 337
VAL A  51
ALA A 270
PHE A  19
 None
 1.26A 4z4eA-5cadA:
undetectable		 4z4eA-5cadA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dll AMINOPEPTIDASE N

(Francisella
tularensis) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		4 PHE A 534
PRO A 540
VAL A 541
PHE A 362
 None
 1.27A 4z4eA-5dllA:
2.4		 4z4eA-5dllA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f4j PROTRUDING DOMAIN OF
GII.17 NOROVIRUS
CAPSID

(Norwalk virus) 		PF08435
(Calici_coat_C) 		4 PHE A 334
PRO A 389
VAL A 390
PHE A 242
 None
 1.21A 4z4eA-5f4jA:
undetectable		 4z4eA-5f4jA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7s GLYCOSIDE HYDROLASE
FAMILY 31

(Trueperella
pyogenes) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 PRO A 681
VAL A 682
ALA A 580
PHE A 540
 None
 0.85A 4z4eA-5f7sA:
undetectable		 4z4eA-5f7sA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5huc 3-DEOXY-D-ARABINO-HE
PTULOSONATE
7-PHOSPHATE (DAHP)
SYNTHASE

(Corynebacterium
glutamicum) 		PF01474
(DAHP_synth_2) 		4 PHE A  90
PRO A 130
VAL A 131
ALA A 127
 None
 1.12A 4z4eA-5hucA:
undetectable		 4z4eA-5hucA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 PHE A 347
VAL A 491
ALA B1154
PHE B1146
 None
 1.26A 4z4eA-5ip9A:
2.6		 4z4eA-5ip9A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5izk SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR

(Homo sapiens) 		PF00009
(GTP_EFTU) 		4 PHE A 416
PRO A 419
VAL A 420
ALA A 314
 None
 1.25A 4z4eA-5izkA:
undetectable		 4z4eA-5izkA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1d PHOSPHATE BINDING
PROTEIN

(Stenotrophomonas
maltophilia) 		PF12849
(PBP_like_2) 		4 PHE A 182
PRO A 165
VAL A 168
ALA A 181
 None
 1.17A 4z4eA-5j1dA:
undetectable		 4z4eA-5j1dA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6b ALDEHYDE
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00171
(Aldedh) 		4 PHE A 439
PRO A 437
VAL A 432
PHE A 412
 None
 1.24A 4z4eA-5j6bA:
2.7		 4z4eA-5j6bA:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jip CORTICAL-LYTIC
ENZYME

(Clostridium
perfringens) 		PF01183
(Glyco_hydro_25) 		4 PRO A 110
VAL A 111
ALA A  72
PHE A  92
 None
 0.85A 4z4eA-5jipA:
2.3		 4z4eA-5jipA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jry NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans) 		PF00171
(Aldedh) 		4 PHE A 439
PRO A 437
VAL A 432
PHE A 412
 None
 1.24A 4z4eA-5jryA:
2.9		 4z4eA-5jryA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5khn RND TRANSPORTER

(Burkholderia
multivorans) 		no annotation 4 PHE B 691
PRO B 530
VAL B 532
ALA B 694
 None
 1.26A 4z4eA-5khnB:
2.0		 4z4eA-5khnB:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m59 PRE-MRNA SPLICING
HELICASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		4 PHE A1566
PRO A1568
VAL A1570
ALA A1401
 None
 1.21A 4z4eA-5m59A:
undetectable		 4z4eA-5m59A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oom 39S RIBOSOMAL
PROTEIN L43,
MITOCHONDRIAL

(Homo sapiens) 		no annotation 4 PHE b  54
PRO b  59
VAL b  61
ALA b  55
 None
 1.29A 4z4eA-5oomb:
undetectable		 4z4eA-5oomb:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thm ESTERASE-6

(Drosophila
melanogaster) 		PF00135
(COesterase) 		4 PHE A 111
PRO A 278
ALA A 110
PHE A 353
 None
None
7BZ  A 601 (-2.9A)
None
 1.23A 4z4eA-5thmA:
3.1		 4z4eA-5thmA:
18.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vm9 PROTEIN ARGONAUTE-3

(Homo sapiens) 		no annotation 5 PHE A 588
PRO A 591
VAL A 592
ALA A 621
PHE A 654
 None
 0.37A 4z4eA-5vm9A:
55.6		 4z4eA-5vm9A:
79.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wea PROTEIN ARGONAUTE-2

(Homo sapiens) 		no annotation 5 PHE A 587
PRO A 590
VAL A 591
ALA A 620
PHE A 653
 None
 0.34A 4z4eA-5weaA:
58.8		 4z4eA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x3j GLYCOSIDE HYDROLASE
FAMILY 31

(Kribbella
flavida) 		no annotation 4 PRO A 665
VAL A 666
ALA A 564
PHE A 524
 None
 0.86A 4z4eA-5x3jA:
undetectable		 4z4eA-5x3jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zya SPLICING FACTOR 3B
SUBUNIT 1

(Homo sapiens) 		no annotation 4 PHE C 532
PRO C 569
VAL C 567
ALA C 528
 None
 1.30A 4z4eA-5zyaC:
undetectable		 4z4eA-5zyaC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bxn DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2

(Candidatus
Methanoperedens
nitroreducens) 		no annotation 4 PHE A 294
PRO A 297
VAL A 298
ALA A 291
 None
 1.08A 4z4eA-6bxnA:
4.0		 4z4eA-6bxnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmz DIHYDROLIPOYL
DEHYDROGENASE

(Burkholderia
cenocepacia) 		no annotation 4 PRO A 150
VAL A 151
ALA A 268
PHE A 158
 None
FAD  A 503 (-4.8A)
None
None
 0.74A 4z4eA-6cmzA:
undetectable		 4z4eA-6cmzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en4 SPLICING FACTOR 3B
SUBUNIT 3

(Homo sapiens) 		no annotation 4 PHE A  68
PRO A 125
VAL A 123
PHE A 182
 None
 1.20A 4z4eA-6en4A:
undetectable		 4z4eA-6en4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhw GLUCOAMYLASE P

(Amorphotheca
resinae) 		no annotation 4 PRO A  58
VAL A  57
ALA A  60
PHE A  77
 None
 1.13A 4z4eA-6fhwA:
undetectable		 4z4eA-6fhwA:
undetectable