SIMILAR PATTERNS OF AMINO ACIDS FOR 4Z4D_A_IPHA903_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c1k BPT4 GENE 59
HELICASE ASSEMBLY
PROTEIN

(Escherichia
virus T4) 		PF08993
(T4_Gp59_N)
PF08994
(T4_Gp59_C) 		4 TYR A  13
LEU A  71
GLU A  70
TYR A  66
 None
 1.31A 4z4dA-1c1kA:
undetectable		 4z4dA-1c1kA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gl9 REVERSE GYRASE

(Archaeoglobus
fulgidus) 		PF00270
(DEAD)
PF01131
(Topoisom_bac)
PF01751
(Toprim) 		4 TYR B 545
LYS B 544
LEU B 667
GLU B 671
 None
 1.42A 4z4dA-1gl9B:
4.5		 4z4dA-1gl9B:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II

(Saccharomyces
cerevisiae) 		PF00150
(Cellulase) 		4 TYR A 220
LYS A 214
LEU A 156
GLU A 153
 None
 1.22A 4z4dA-1h4pA:
1.3		 4z4dA-1h4pA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oah CYTOCHROME C NITRITE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF02335
(Cytochrom_C552) 		4 TYR A 112
LYS A  81
GLU A 114
TYR A  79
 HEM  A1520 (-4.9A)
None
CA  A1526 ( 3.4A)
None
 1.41A 4z4dA-1oahA:
undetectable		 4z4dA-1oahA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pml TISSUE PLASMINOGEN
ACTIVATOR KRINGLE 2

(Homo sapiens) 		PF00051
(Kringle) 		4 TYR A   2
LYS A  59
GLU A  17
TYR A  74
 None
 1.44A 4z4dA-1pmlA:
undetectable		 4z4dA-1pmlA:
7.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ybe NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Agrobacterium
tumefaciens) 		PF04095
(NAPRTase) 		4 TYR A  37
LYS A  38
LEU A 251
GLU A 250
 None
 1.19A 4z4dA-1ybeA:
0.6		 4z4dA-1ybeA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e9x DNA REPLICATION
COMPLEX GINS PROTEIN
PSF2

(Homo sapiens) 		PF05916
(Sld5) 		4 TYR B  92
LEU B  95
GLU B  94
TYR B  91
 None
 1.47A 4z4dA-2e9xB:
0.0		 4z4dA-2e9xB:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2quq CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
B

(Saccharomyces
cerevisiae) 		PF16846
(Cep3) 		4 TYR A 105
LEU A 192
GLU A 190
TYR A 191
 None
 1.34A 4z4dA-2quqA:
0.0		 4z4dA-2quqA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zqb RIBONUCLEASE HI

(Shewanella
oneidensis) 		PF00075
(RNase_H) 		4 TYR A  30
LYS A   5
LEU A  61
GLU A  63
 None
 1.24A 4z4dA-2zqbA:
6.7		 4z4dA-2zqbA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1n NDP-SUGAR EPIMERASE

(Thermoplasma
volcanium) 		PF01370
(Epimerase) 		4 TYR A 150
LEU A  96
GLU A  97
TYR A  93
 None
 1.46A 4z4dA-3a1nA:
0.0		 4z4dA-3a1nA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3glq ADENOSYLHOMOCYSTEINA
SE

(Burkholderia
pseudomallei) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 TYR A 425
LEU A 207
GLU A 211
TYR A 208
 None
 1.09A 4z4dA-3glqA:
0.0		 4z4dA-3glqA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i23 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY

(Enterococcus
faecalis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 TYR A 309
LYS A 313
LEU A  68
GLU A  67
 None
 1.12A 4z4dA-3i23A:
3.7		 4z4dA-3i23A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbk RIG-I HELICASE
DOMAIN

(Mus musculus) 		PF00271
(Helicase_C)
PF04851
(ResIII) 		4 LYS A 611
LEU A 742
GLU A 717
TYR A 716
 None
 1.37A 4z4dA-3tbkA:
0.9		 4z4dA-3tbkA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i2w PROTEIN UNC-45

(Caenorhabditis
elegans) 		PF11701
(UNC45-central) 		4 TYR A 413
LYS A 416
LEU A 356
GLU A 358
 None
 1.34A 4z4dA-4i2wA:
undetectable		 4z4dA-4i2wA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1

(Homo sapiens) 		PF05994
(FragX_IP)
PF07159
(DUF1394) 		4 LYS A 389
LEU A 363
GLU A 362
TYR A 366
 None
 1.44A 4z4dA-4n78A:
undetectable		 4z4dA-4n78A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4on9 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 LYS A 610
LEU A 741
GLU A 716
TYR A 715
 None
 1.25A 4z4dA-4on9A:
undetectable		 4z4dA-4on9A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfk ABC TRANSPORTER
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Pseudoalteromonas
sp. SM9913) 		no annotation 4 TYR H 232
LYS H 234
LEU H  78
GLU H  77
 None
 1.40A 4z4dA-4qfkH:
undetectable		 4z4dA-4qfkH:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gu6 ENDOPLASMIC
RETICULUM RESIDENT
PROTEIN 44

(Homo sapiens) 		PF00085
(Thioredoxin)
PF13848
(Thioredoxin_6) 		4 TYR A 368
LYS A  77
LEU A  81
GLU A  93
 None
 1.25A 4z4dA-5gu6A:
undetectable		 4z4dA-5gu6A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3h ABHYDROLASE
DOMAIN-CONTAINING
PROTEIN

(Exiguobacterium
antarcticum) 		PF00561
(Abhydrolase_1)
PF08386
(Abhydrolase_4) 		4 LYS A 267
LEU A  44
GLU A  47
TYR A  49
 None
 1.48A 4z4dA-5h3hA:
2.6		 4z4dA-5h3hA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5p PRE-MRNA-SPLICING
HELICASE BRR2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		4 TYR A1193
LYS A1197
LEU A1173
GLU A1174
 None
 1.10A 4z4dA-5m5pA:
undetectable		 4z4dA-5m5pA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uam ULVAN LYASE-PL25

(Pseudoalteromonas
sp. PLSV) 		PF15892
(BNR_4) 		4 TYR A 140
LYS A 163
LEU A 111
GLU A 110
 None
 1.39A 4z4dA-5uamA:
undetectable		 4z4dA-5uamA:
19.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vm9 PROTEIN ARGONAUTE-3

(Homo sapiens) 		no annotation 5 TYR A 655
LYS A 661
LEU A 695
GLU A 696
TYR A 699
 None
 0.92A 4z4dA-5vm9A:
55.7		 4z4dA-5vm9A:
79.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wea PROTEIN ARGONAUTE-2

(Homo sapiens) 		no annotation 4 LYS A 660
LEU A 694
GLU A 695
TYR A 698
 None
IPH  A 901 (-3.9A)
IPH  A 901 (-3.6A)
IPH  A 901 ( 4.9A)
 1.01A 4z4dA-5weaA:
58.8		 4z4dA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wea PROTEIN ARGONAUTE-2

(Homo sapiens) 		no annotation 4 TYR A 654
LEU A 694
GLU A 695
TYR A 698
 None
IPH  A 901 (-3.9A)
IPH  A 901 (-3.6A)
IPH  A 901 ( 4.9A)
 0.58A 4z4dA-5weaA:
58.8		 4z4dA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eyy ACRIIA6

(Streptococcus
phage 73) 		no annotation 4 TYR A  79
LEU A  10
GLU A   9
TYR A  92
 None
 1.45A 4z4dA-6eyyA:
undetectable		 4z4dA-6eyyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdt -

(-) 		no annotation 4 TYR A 349
LYS A 351
LEU A 379
GLU A 380
 None
 0.93A 4z4dA-6fdtA:
undetectable		 4z4dA-6fdtA:
undetectable