SIMILAR PATTERNS OF AMINO ACIDS FOR 4Z4C_A_IPHA904_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxk PROTEIN
(DTDP-GLUCOSE
4,6-DEHYDRATASE)

(Escherichia
coli) 		PF16363
(GDP_Man_Dehyd) 		4 LYS A 277
PRO A 278
GLU A 271
TYR A 284
 None
 1.37A 4z4cA-1bxkA:
3.1		 4z4cA-1bxkA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxk PROTEIN
(DTDP-GLUCOSE
4,6-DEHYDRATASE)

(Escherichia
coli) 		PF16363
(GDP_Man_Dehyd) 		4 LYS A 277
PRO A 278
LEU A 270
GLU A 271
 None
 1.05A 4z4cA-1bxkA:
3.1		 4z4cA-1bxkA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c1k BPT4 GENE 59
HELICASE ASSEMBLY
PROTEIN

(Escherichia
virus T4) 		PF08993
(T4_Gp59_N)
PF08994
(T4_Gp59_C) 		4 TYR A  13
LEU A  71
GLU A  70
TYR A  66
 None
 1.31A 4z4cA-1c1kA:
undetectable		 4z4cA-1c1kA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1egj CYTOKINE RECEPTOR
COMMON BETA CHAIN
PRECURSOR

(Homo sapiens) 		PF00041
(fn3) 		4 TYR A 354
PRO A 400
LEU A 356
TYR A 376
 None
 1.42A 4z4cA-1egjA:
undetectable		 4z4cA-1egjA:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gl9 REVERSE GYRASE

(Archaeoglobus
fulgidus) 		PF00270
(DEAD)
PF01131
(Topoisom_bac)
PF01751
(Toprim) 		4 TYR B 545
LYS B 544
LEU B 667
GLU B 671
 None
 1.37A 4z4cA-1gl9B:
3.5		 4z4cA-1gl9B:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II

(Saccharomyces
cerevisiae) 		PF00150
(Cellulase) 		4 TYR A 220
LYS A 214
LEU A 156
GLU A 153
 None
 1.24A 4z4cA-1h4pA:
2.2		 4z4cA-1h4pA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1knb ADENOVIRUS TYPE 5
FIBER PROTEIN

(Human
mastadenovirus
C) 		PF00541
(Adeno_knob) 		4 LYS A 528
PRO A 529
GLU A 566
TYR A 563
 None
 1.04A 4z4cA-1knbA:
undetectable		 4z4cA-1knbA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oah CYTOCHROME C NITRITE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF02335
(Cytochrom_C552) 		4 TYR A 112
LYS A  81
GLU A 114
TYR A  79
 HEM  A1520 (-4.9A)
None
CA  A1526 ( 3.4A)
None
 1.39A 4z4cA-1oahA:
undetectable		 4z4cA-1oahA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhv PROTEIN (ADENOVIRUS
FIBRE)

(Human
mastadenovirus
C) 		PF00541
(Adeno_knob) 		4 LYS A 528
PRO A 529
GLU A 567
TYR A 564
 None
 1.14A 4z4cA-1qhvA:
undetectable		 4z4cA-1qhvA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qiu ADENOVIRUS FIBRE

(Human
mastadenovirus
C) 		PF00541
(Adeno_knob)
PF00608
(Adeno_shaft) 		4 LYS A 528
PRO A 529
GLU A 567
TYR A 564
 None
 1.16A 4z4cA-1qiuA:
undetectable		 4z4cA-1qiuA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rpt PROSTATIC ACID
PHOSPHATASE

(Rattus
norvegicus) 		PF00328
(His_Phos_2) 		4 PRO A 307
LEU A  49
GLU A  48
TYR A  52
 None
 1.10A 4z4cA-1rptA:
undetectable		 4z4cA-1rptA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1upx HYDROXYLAMINE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF03063
(Prismane) 		4 LYS A 313
PRO A 312
GLU A 296
TYR A 316
 None
 1.16A 4z4cA-1upxA:
3.8		 4z4cA-1upxA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5f PYRUVATE OXIDASE

(Aerococcus
viridans) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 TYR A 178
LYS A 143
PRO A 142
GLU A 147
 None
 1.41A 4z4cA-1v5fA:
4.4		 4z4cA-1v5fA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
METHANOL
DEHYDROGENASE
SUBUNIT 2

(Methylobacterium
extorquens;
Methylobacterium
extorquens) 		PF01011
(PQQ)
PF13360
(PQQ_2)
PF02315
(MDH) 		4 TYR B1001
LYS B1016
PRO B1017
GLU A 267
 None
 1.33A 4z4cA-1w6sB:
undetectable		 4z4cA-1w6sB:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wv9 RHODANESE HOMOLOG
TT1651

(Thermus
thermophilus) 		no annotation 4 PRO A  52
LEU A  73
GLU A  76
TYR A  78
 None
 1.28A 4z4cA-1wv9A:
undetectable		 4z4cA-1wv9A:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wzo HPCE

(Thermus
thermophilus) 		PF01557
(FAA_hydrolase) 		4 PRO A  65
LEU A 195
GLU A 194
TYR A 190
 None
 1.35A 4z4cA-1wzoA:
undetectable		 4z4cA-1wzoA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdz METHYLTRANSFERASE
GIDB

(Bacillus
subtilis) 		PF02527
(GidB) 		4 TYR A  51
PRO A  86
LEU A  32
TYR A  28
 None
 1.38A 4z4cA-1xdzA:
undetectable		 4z4cA-1xdzA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ybe NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Agrobacterium
tumefaciens) 		PF04095
(NAPRTase) 		4 TYR A  37
LYS A  38
LEU A 251
GLU A 250
 None
 1.03A 4z4cA-1ybeA:
undetectable		 4z4cA-1ybeA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yd6 UVRC

([Bacillus]
caldotenax) 		PF01541
(GIY-YIG) 		4 LYS A  88
PRO A  87
LEU A  56
GLU A  59
 None
 1.30A 4z4cA-1yd6A:
undetectable		 4z4cA-1yd6A:
7.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b24 NAPHTHALENE
DIOXYGENASE LARGE
SUBUNIT

(Rhodococcus sp.
NCIMB 12038) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		4 LYS A 174
LEU A 166
GLU A 167
TYR A 151
 None
 1.29A 4z4cA-2b24A:
undetectable		 4z4cA-2b24A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
METHANOL
DEHYDROGENASE SMALL
SUBUNIT

(Hyphomicrobium
denitrificans;
Hyphomicrobium
denitrificans) 		PF01011
(PQQ)
PF13360
(PQQ_2)
PF02315
(MDH) 		4 TYR B   1
LYS B  16
PRO B  17
GLU A 267
 None
 1.34A 4z4cA-2d0vB:
undetectable		 4z4cA-2d0vB:
6.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dh4 YPL069C

(Saccharomyces
cerevisiae) 		PF00348
(polyprenyl_synt) 		4 TYR A 216
LYS A 220
LEU A 283
GLU A 284
 None
 1.07A 4z4cA-2dh4A:
undetectable		 4z4cA-2dh4A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ezi TRANSPOSASE

(Escherichia
virus Mu) 		PF09039
(HTH_Tnp_Mu_2) 		4 PRO A 219
LEU A 207
GLU A 208
TYR A 204
 None
 1.24A 4z4cA-2eziA:
undetectable		 4z4cA-2eziA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g5t DIPEPTIDYL PEPTIDASE
4

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 TYR A 132
PRO A 149
LEU A 164
TYR A 166
 None
 1.30A 4z4cA-2g5tA:
3.1		 4z4cA-2g5tA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gdq YITF

(Bacillus
subtilis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 TYR A 195
PRO A 221
LEU A 231
TYR A 228
 None
 1.40A 4z4cA-2gdqA:
undetectable		 4z4cA-2gdqA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpa PROTEIN (ACID
PHOSPHATASE)

(Homo sapiens) 		PF00328
(His_Phos_2) 		4 PRO A1307
LEU A1049
GLU A1048
TYR A1052
 None
 1.11A 4z4cA-2hpaA:
undetectable		 4z4cA-2hpaA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuk SEED LIPOXYGENASE

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 TYR A 317
PRO A 352
LEU A 774
TYR A 724
 None
 1.40A 4z4cA-2iukA:
undetectable		 4z4cA-2iukA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k47 PHOSPHOPROTEIN

(Indiana
vesiculovirus) 		PF00922
(Phosphoprotein) 		4 LYS A  16
PRO A  15
LEU A  71
GLU A  73
 None
 1.27A 4z4cA-2k47A:
undetectable		 4z4cA-2k47A:
7.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obe HEXON

(Human
mastadenovirus
E) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		4 TYR A 351
LYS A 545
GLU A 348
TYR A 320
 None
 1.38A 4z4cA-2obeA:
undetectable		 4z4cA-2obeA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2opc AVRL567-A

(Melampsora lini) 		PF11529
(AvrL567-A) 		4 TYR A 141
PRO A 139
LEU A 130
GLU A 132
 None
 1.39A 4z4cA-2opcA:
undetectable		 4z4cA-2opcA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2quq CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
B

(Saccharomyces
cerevisiae) 		PF16846
(Cep3) 		4 TYR A 105
LEU A 192
GLU A 190
TYR A 191
 None
 1.33A 4z4cA-2quqA:
undetectable		 4z4cA-2quqA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r66 GLYCOSYL
TRANSFERASE, GROUP 1

(Halothermothrix
orenii) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		4 TYR A 250
LYS A 246
LEU A 342
GLU A 347
 None
 1.32A 4z4cA-2r66A:
4.6		 4z4cA-2r66A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wmo DEDICATOR OF
CYTOKINESIS PROTEIN
9

(Homo sapiens) 		PF06920
(DHR-2) 		4 LYS A 180
PRO A 179
LEU A  27
GLU A 102
 None
 1.37A 4z4cA-2wmoA:
undetectable		 4z4cA-2wmoA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyb LACCASE

(Trametes
cinnabarina) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 LYS A 298
PRO A 299
LEU A 231
GLU A 232
 None
 1.28A 4z4cA-2xybA:
undetectable		 4z4cA-2xybA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2za8 FERRITIN LIGHT CHAIN

(Equus caballus) 		PF00210
(Ferritin) 		4 TYR A  24
LYS A  59
LEU A 103
GLU A 104
 None
 0.93A 4z4cA-2za8A:
undetectable		 4z4cA-2za8A:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zc0 ALANINE GLYOXYLATE
TRANSAMINASE

(Thermococcus
litoralis) 		PF00155
(Aminotran_1_2) 		4 LYS A 330
PRO A 331
LEU A 319
GLU A 320
 None
 0.81A 4z4cA-2zc0A:
2.4		 4z4cA-2zc0A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2f DNA POLYMERASE

(Pyrococcus
furiosus) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 TYR A 654
PRO A 723
LEU A 661
TYR A 721
 None
 1.04A 4z4cA-3a2fA:
undetectable		 4z4cA-3a2fA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ceg BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 6

(Homo sapiens) 		PF00179
(UQ_con) 		4 TYR A4603
PRO A4613
LEU A4550
TYR A4608
 None
 1.27A 4z4cA-3cegA:
undetectable		 4z4cA-3cegA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dec BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 TYR A 501
PRO A 975
LEU A 522
TYR A 539
 None
 1.22A 4z4cA-3decA:
undetectable		 4z4cA-3decA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ffr PHOSPHOSERINE
AMINOTRANSFERASE
SERC

(Cytophaga
hutchinsonii) 		PF00266
(Aminotran_5) 		4 LYS A 175
PRO A 174
LEU A  54
GLU A  56
 None
 1.35A 4z4cA-3ffrA:
2.2		 4z4cA-3ffrA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3glq ADENOSYLHOMOCYSTEINA
SE

(Burkholderia
pseudomallei) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 TYR A 425
LEU A 207
GLU A 211
TYR A 208
 None
 1.04A 4z4cA-3glqA:
2.4		 4z4cA-3glqA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gmt ADENYLATE KINASE

(Burkholderia
pseudomallei) 		PF00406
(ADK)
PF05191
(ADK_lid) 		4 LYS A 176
PRO A 177
LEU A   6
GLU A 108
 None
 1.35A 4z4cA-3gmtA:
2.3		 4z4cA-3gmtA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3grn MUTT RELATED PROTEIN

(Methanosarcina
mazei) 		PF00293
(NUDIX) 		4 LYS A   5
PRO A   6
LEU A  80
GLU A  79
 None
 1.41A 4z4cA-3grnA:
undetectable		 4z4cA-3grnA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i0u PHOSPHOTHREONINE
LYASE OSPF

(Shigella
flexneri) 		PF03536
(VRP3) 		4 PRO A 192
LEU A 186
GLU A 182
TYR A 207
 None
 1.26A 4z4cA-3i0uA:
undetectable		 4z4cA-3i0uA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i23 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY

(Enterococcus
faecalis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 TYR A 309
LYS A 313
LEU A  68
GLU A  67
 None
 0.97A 4z4cA-3i23A:
4.9		 4z4cA-3i23A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l0o TRANSCRIPTION
TERMINATION FACTOR
RHO

(Thermotoga
maritima) 		PF00006
(ATP-synt_ab)
PF07497
(Rho_RNA_bind)
PF07498
(Rho_N) 		4 LYS A 300
PRO A 301
LEU A 251
GLU A 248
 None
 1.39A 4z4cA-3l0oA:
undetectable		 4z4cA-3l0oA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ob8 BETA-GALACTOSIDASE

(Kluyveromyces
lactis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N) 		4 TYR A 523
PRO A1003
LEU A 549
TYR A 566
 None
 1.37A 4z4cA-3ob8A:
1.7		 4z4cA-3ob8A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ozx RNASE L INHIBITOR

(Sulfolobus
solfataricus) 		PF00005
(ABC_tran) 		4 TYR A 417
PRO A 415
LEU A 468
TYR A 469
 None
 1.35A 4z4cA-3ozxA:
undetectable		 4z4cA-3ozxA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pnt IMMUNITY FACTOR FOR
SPN

(Streptococcus
pyogenes) 		PF16718
(IFS) 		4 TYR B  56
PRO B  60
LEU B 102
TYR B   2
 None
 1.22A 4z4cA-3pntB:
undetectable		 4z4cA-3pntB:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rt2 ABSCISIC ACID
RECEPTOR PYL10

(Arabidopsis
thaliana) 		PF10604
(Polyketide_cyc2) 		4 TYR A  55
LYS A  56
PRO A  57
LEU A 164
 None
 1.38A 4z4cA-3rt2A:
3.0		 4z4cA-3rt2A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s25 HYPOTHETICAL
7-BLADED
BETA-PROPELLER-LIKE
PROTEIN

([Eubacterium]
rectale) 		PF16472
(DUF5050) 		4 TYR A 216
LYS A 217
PRO A 218
TYR A  44
 None
None
None
EDO  A 334 (-4.4A)
 1.26A 4z4cA-3s25A:
undetectable		 4z4cA-3s25A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbk RIG-I HELICASE
DOMAIN

(Mus musculus) 		PF00271
(Helicase_C)
PF04851
(ResIII) 		4 LYS A 611
LEU A 742
GLU A 717
TYR A 716
 None
 1.38A 4z4cA-3tbkA:
undetectable		 4z4cA-3tbkA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tos CALS11

(Micromonospora
echinospora) 		PF05711
(TylF) 		4 TYR A 193
PRO A 195
LEU A 200
GLU A 201
 None
SAH  A 258 (-4.1A)
None
None
 1.00A 4z4cA-3tosA:
3.1		 4z4cA-3tosA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3voh CELLOBIOHYDROLASE

(Coprinopsis
cinerea) 		PF01341
(Glyco_hydro_6) 		4 TYR A 198
LYS A 197
LEU A 133
GLU A 194
 None
 1.32A 4z4cA-3vohA:
undetectable		 4z4cA-3vohA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsv XYLOSIDASE

(Thermoanaerobacterium
saccharolyticum) 		PF13229
(Beta_helix) 		4 LYS A 283
PRO A 284
LEU A 290
GLU A 291
 None
 1.04A 4z4cA-3vsvA:
undetectable		 4z4cA-3vsvA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vx6 E1

(Kluyveromyces
marxianus) 		PF16420
(ATG7_N) 		4 TYR A 134
LYS A 269
PRO A 268
GLU A 259
 None
 1.13A 4z4cA-3vx6A:
undetectable		 4z4cA-3vx6A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zif HEXON PROTEIN

(Bovine
mastadenovirus
B) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		4 TYR A 337
LYS A 527
GLU A 334
TYR A 306
 None
 1.26A 4z4cA-3zifA:
undetectable		 4z4cA-3zifA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cek REGULATOR OF
NONSENSE TRANSCRIPTS
2

(Homo sapiens) 		PF02854
(MIF4G) 		4 TYR A 753
PRO A 757
LEU A 728
GLU A 729
 None
 1.21A 4z4cA-4cekA:
undetectable		 4z4cA-4cekA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e2i LARGE T ANTIGEN

(Macaca mulatta
polyomavirus 1) 		PF06431
(Polyoma_lg_T_C) 		4 TYR A 406
LYS A 410
LEU A 361
GLU A 358
 None
 1.24A 4z4cA-4e2iA:
undetectable		 4z4cA-4e2iA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fcy TRANSPOSASE

(Escherichia
virus Mu) 		PF02316
(HTH_Tnp_Mu_1)
PF02914
(DDE_2)
PF09039
(HTH_Tnp_Mu_2)
PF09299
(Mu-transpos_C) 		4 PRO A 219
LEU A 207
GLU A 208
TYR A 204
 None
 1.29A 4z4cA-4fcyA:
undetectable		 4z4cA-4fcyA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gyv FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 2

(Mus musculus) 		PF00621
(RhoGEF) 		4 PRO A 684
LEU A 554
GLU A 550
TYR A 553
 None
 1.14A 4z4cA-4gyvA:
undetectable		 4z4cA-4gyvA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h5b DR_1245 PROTEIN

(Deinococcus
radiodurans) 		PF10722
(YbjN) 		4 LYS A  68
LEU A 137
GLU A 138
TYR A 134
 None
 1.39A 4z4cA-4h5bA:
undetectable		 4z4cA-4h5bA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h6y FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00169
(PH)
PF00621
(RhoGEF) 		4 PRO A 685
LEU A 556
GLU A 552
TYR A 555
 None
 1.31A 4z4cA-4h6yA:
undetectable		 4z4cA-4h6yA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i05 CATHEPSIN B-LIKE
PEPTIDASE (C01
FAMILY)

(Schistosoma
mansoni) 		PF00112
(Peptidase_C1) 		4 TYR A 186
LYS A 177
PRO A 176
GLU A 165
 None
 1.13A 4z4cA-4i05A:
undetectable		 4z4cA-4i05A:
15.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4krf PROTEIN ARGONAUTE-1

(Homo sapiens) 		PF02170
(PAZ)
PF02171
(Piwi)
PF08699
(ArgoL1)
PF16486
(ArgoN)
PF16487
(ArgoMid)
PF16488
(ArgoL2) 		4 TYR A 652
PRO A 659
LEU A 692
TYR A 696
 None
 0.40A 4z4cA-4krfA:
59.6		 4z4cA-4krfA:
82.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mh0 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Mus musculus) 		PF00027
(cNMP_binding)
PF00617
(RasGEF)
PF00618
(RasGEF_N) 		4 LYS E 643
PRO E 645
LEU E 769
GLU E 768
 None
 1.39A 4z4cA-4mh0E:
undetectable		 4z4cA-4mh0E:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6z SERINE
HYDROXYMETHYLTRANSFE
RASE

(Plasmodium
falciparum) 		PF00464
(SHMT) 		4 LYS A 424
PRO A 423
LEU A 404
GLU A 403
 None
 1.32A 4z4cA-4o6zA:
2.2		 4z4cA-4o6zA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4on9 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 LYS A 610
LEU A 741
GLU A 716
TYR A 715
 None
 1.27A 4z4cA-4on9A:
2.1		 4z4cA-4on9A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfk ABC TRANSPORTER
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Pseudoalteromonas
sp. SM9913) 		no annotation 4 TYR H 232
LYS H 234
LEU H  78
GLU H  77
 None
 1.30A 4z4cA-4qfkH:
undetectable		 4z4cA-4qfkH:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qme AMINOPEPTIDASE N

(Neisseria
meningitidis) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		4 TYR A 181
PRO A 118
GLU A 316
TYR A 372
 None
37B  A 901 ( 4.7A)
ZN  A 908 ( 2.0A)
37B  A 901 (-3.5A)
 1.33A 4z4cA-4qmeA:
3.4		 4z4cA-4qmeA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT
METHANOL
DEHYDROGENASE, SMALL
SUBUNIT

(Methylococcus
capsulatus;
Methylococcus
capsulatus) 		no annotation
PF02315
(MDH) 		4 TYR I  23
LYS I  38
PRO I  39
GLU B 295
 None
 1.28A 4z4cA-4tqoI:
undetectable		 4z4cA-4tqoI:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u63 DNA PHOTOLYASE

(Agrobacterium
fabrum) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		4 TYR A 431
LYS A 434
PRO A 435
GLU A 408
 None
 1.26A 4z4cA-4u63A:
4.0		 4z4cA-4u63A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uir OLEATE HYDRATASE

(Elizabethkingia
meningoseptica) 		PF06100
(MCRA) 		4 LYS A 262
PRO A 261
LEU A 140
GLU A 141
 None
 1.36A 4z4cA-4uirA:
2.4		 4z4cA-4uirA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhj ENVELOPE
GLYCOPROTEIN L

(Human
alphaherpesvirus
3) 		PF05259
(Herpes_UL1) 		4 LYS B  36
PRO B  37
LEU B  43
GLU B  47
 None
 1.35A 4z4cA-4xhjB:
undetectable		 4z4cA-4xhjB:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zu9 ELONGATION FACTOR
SELB

(Aquifex
aeolicus) 		PF00009
(GTP_EFTU)
PF09107
(SelB-wing_3) 		4 LYS A 502
PRO A 501
LEU A 463
GLU A 462
 None
 1.30A 4z4cA-4zu9A:
3.4		 4z4cA-4zu9A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a4j FORMATE--TETRAHYDROF
OLATE LIGASE

(Tepidanaerobacter
acetatoxydans) 		PF01268
(FTHFS) 		4 TYR A  44
LYS A 255
PRO A 256
GLU A  33
 EDO  A1562 (-4.5A)
EDO  A1562 (-3.2A)
None
None
 0.83A 4z4cA-5a4jA:
6.6		 4z4cA-5a4jA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5g FORMATE--TETRAHYDROF
OLATE LIGASE

(Tepidanaerobacter
acetatoxydans) 		PF01268
(FTHFS) 		4 TYR A  44
LYS A 254
PRO A 255
LEU A  46
 None
 1.35A 4z4cA-5a5gA:
undetectable		 4z4cA-5a5gA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fms INTRAFLAGELLAR
TRANSPORT PROTEIN 52
HOMOLOG

(Mus musculus) 		PF09822
(ABC_transp_aux) 		4 LYS A  74
LEU A 103
GLU A 105
TYR A 106
 None
 1.17A 4z4cA-5fmsA:
undetectable		 4z4cA-5fmsA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gu6 ENDOPLASMIC
RETICULUM RESIDENT
PROTEIN 44

(Homo sapiens) 		PF00085
(Thioredoxin)
PF13848
(Thioredoxin_6) 		4 TYR A 368
LYS A  77
LEU A  81
GLU A  93
 None
 1.21A 4z4cA-5gu6A:
undetectable		 4z4cA-5gu6A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3h ABHYDROLASE
DOMAIN-CONTAINING
PROTEIN

(Exiguobacterium
antarcticum) 		PF00561
(Abhydrolase_1)
PF08386
(Abhydrolase_4) 		4 LYS A 267
LEU A  44
GLU A  47
TYR A  49
 None
 1.37A 4z4cA-5h3hA:
3.1		 4z4cA-5h3hA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6h ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		4 TYR A1127
PRO A1126
LEU A1102
TYR A1120
 None
 1.18A 4z4cA-5i6hA:
undetectable		 4z4cA-5i6hA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6i ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		4 TYR A1127
PRO A1126
LEU A1102
TYR A1120
 None
 1.27A 4z4cA-5i6iA:
2.4		 4z4cA-5i6iA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i85 SPHINGOMYELIN
PHOSPHODIESTERASE

(Homo sapiens) 		PF00149
(Metallophos) 		4 TYR A 274
PRO A 314
LEU A 369
TYR A 367
 None
 1.24A 4z4cA-5i85A:
undetectable		 4z4cA-5i85A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjh 4-ALPHA-GLUCANOTRANS
FERASE

(Corynebacterium
glutamicum) 		PF02446
(Glyco_hydro_77) 		4 LYS A 657
PRO A 564
LEU A 569
GLU A 570
 None
 1.36A 4z4cA-5jjhA:
undetectable		 4z4cA-5jjhA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE BETA
SUBUNIT

(Aromatoleum
aromaticum) 		PF08882
(Acetone_carb_G) 		4 TYR C  86
PRO C  47
LEU C  71
GLU C  72
 None
 1.35A 4z4cA-5l9wC:
undetectable		 4z4cA-5l9wC:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lg8 FERRITIN LIGHT CHAIN

(Homo sapiens) 		PF00210
(Ferritin) 		4 TYR A  27
LYS A  62
LEU A 106
GLU A 107
 None
 0.92A 4z4cA-5lg8A:
undetectable		 4z4cA-5lg8A:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5p PRE-MRNA-SPLICING
HELICASE BRR2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		4 TYR A1193
LYS A1197
LEU A1173
GLU A1174
 None
 1.09A 4z4cA-5m5pA:
2.3		 4z4cA-5m5pA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkk MULTIDRUG RESISTANCE
ABC TRANSPORTER
ATP-BINDING AND
PERMEASE PROTEIN

(Thermus
thermophilus) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 TYR A 410
PRO A 412
LEU A 337
GLU A 336
 None
 1.30A 4z4cA-5mkkA:
undetectable		 4z4cA-5mkkA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mus L PROTEIN

(California
reptarenavirus) 		no annotation 4 TYR A1787
PRO A1746
GLU A1792
TYR A1776
 None
 1.42A 4z4cA-5musA:
undetectable		 4z4cA-5musA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uam ULVAN LYASE-PL25

(Pseudoalteromonas
sp. PLSV) 		PF15892
(BNR_4) 		4 TYR A 140
LYS A 163
LEU A 111
GLU A 110
 None
 1.29A 4z4cA-5uamA:
undetectable		 4z4cA-5uamA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj8 ORIGIN RECOGNITION
COMPLEX SUBUNIT 3

(Homo sapiens) 		PF07034
(ORC3_N) 		4 TYR A 429
PRO A 430
LEU A 438
GLU A 437
 None
 1.15A 4z4cA-5uj8A:
undetectable		 4z4cA-5uj8A:
21.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vm9 PROTEIN ARGONAUTE-3

(Homo sapiens) 		no annotation 6 TYR A 655
LYS A 661
PRO A 662
LEU A 695
GLU A 696
TYR A 699
 None
 0.77A 4z4cA-5vm9A:
55.3		 4z4cA-5vm9A:
79.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wea PROTEIN ARGONAUTE-2

(Homo sapiens) 		no annotation 5 LYS A 660
PRO A 661
LEU A 694
GLU A 695
TYR A 698
 None
None
IPH  A 901 (-3.9A)
IPH  A 901 (-3.6A)
IPH  A 901 ( 4.9A)
 0.80A 4z4cA-5weaA:
58.5		 4z4cA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wea PROTEIN ARGONAUTE-2

(Homo sapiens) 		no annotation 5 TYR A 654
PRO A 661
LEU A 694
GLU A 695
TYR A 698
 None
None
IPH  A 901 (-3.9A)
IPH  A 901 (-3.6A)
IPH  A 901 ( 4.9A)
 0.50A 4z4cA-5weaA:
58.5		 4z4cA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wy3 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		no annotation 4 TYR A  81
PRO A  76
LEU A 109
GLU A 111
 None
 1.42A 4z4cA-5wy3A:
undetectable		 4z4cA-5wy3A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xm3 GLUCOSE
DEHYDROGENASE
METHANOL
DEHYDROGENASE
[CYTOCHROME C]
SUBUNIT 2

(Methylophaga
aminisulfidivorans;
Methylophaga
aminisulfidivorans) 		no annotation
no annotation 		4 TYR B  25
LYS B  40
PRO B  41
GLU A 298
 None
 1.27A 4z4cA-5xm3B:
undetectable		 4z4cA-5xm3B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z8l -

(-) 		no annotation 4 TYR A  49
PRO A  47
LEU A  38
GLU A 105
 None
 1.20A 4z4cA-5z8lA:
undetectable		 4z4cA-5z8lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z8n -

(-) 		no annotation 4 TYR A  49
PRO A  47
LEU A  38
GLU A 105
 None
 1.40A 4z4cA-5z8nA:
3.2		 4z4cA-5z8nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c66 CRISPR-ASSOCIATED
PROTEIN, CSE4 FAMILY

(Thermobifida
fusca) 		no annotation 4 PRO B 298
LEU B 318
GLU B 317
TYR B 321
 None
 1.32A 4z4cA-6c66B:
undetectable		 4z4cA-6c66B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdt -

(-) 		no annotation 4 TYR A 349
LYS A 351
LEU A 379
GLU A 380
 None
 0.94A 4z4cA-6fdtA:
undetectable		 4z4cA-6fdtA:
undetectable