SIMILAR PATTERNS OF AMINO ACIDS FOR 4Z2E_H_TR6H101_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c41 LUMAZINE SYNTHASE

(Magnaporthe
grisea) 		PF00885
(DMRL_synthase) 		3 GLY A 168
GLY A 172
GLU A 171
 None
 0.49A 4z2eA-1c41A:
0.0
4z2eD-1c41A:
2.1		 4z2eA-1c41A:
18.22
4z2eD-1c41A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4o MALTODEXTRIN
PHOSPHORYLASE

(Escherichia
coli) 		PF00343
(Phosphorylase) 		3 GLY A 114
GLY A 640
GLU A 637
 PLP  A 999 ( 3.6A)
PLP  A 999 ( 3.2A)
GLC  A 998 (-3.6A)
 0.52A 4z2eA-1e4oA:
undetectable
4z2eD-1e4oA:
2.3		 4z2eA-1e4oA:
21.84
4z2eD-1e4oA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fqt RIESKE-TYPE
FERREDOXIN OF
BIPHENYL DIOXYGENASE

(Paraburkholderia
xenovorans) 		PF00355
(Rieske) 		3 GLY A  15
GLY A  58
GLU A  57
 None
 0.45A 4z2eA-1fqtA:
undetectable
4z2eD-1fqtA:
undetectable		 4z2eA-1fqtA:
13.54
4z2eD-1fqtA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iwa RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE/OXYGENAS
E SMALL SUBUNIT

(Galdieria
partita) 		PF00101
(RuBisCO_small) 		3 GLY B 103
GLY B  41
GLU B  43
 None
 0.43A 4z2eA-1iwaB:
undetectable
4z2eD-1iwaB:
undetectable		 4z2eA-1iwaB:
16.11
4z2eD-1iwaB:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1koa TWITCHIN

(Caenorhabditis
elegans) 		PF00069
(Pkinase)
PF07679
(I-set) 		3 GLY A5951
GLY A5949
GLU A5947
 None
 0.48A 4z2eA-1koaA:
3.3
4z2eD-1koaA:
undetectable		 4z2eA-1koaA:
21.74
4z2eD-1koaA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ltz PHENYLALANINE-4-HYDR
OXYLASE

(Chromobacterium
violaceum) 		PF00351
(Biopterin_H) 		3 GLY A 142
GLY A 200
GLU A 184
 None
None
FE  A 400 (-1.9A)
 0.43A 4z2eA-1ltzA:
undetectable
4z2eD-1ltzA:
undetectable		 4z2eA-1ltzA:
19.84
4z2eD-1ltzA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mdf 2,3-DIHYDROXYBENZOAT
E-AMP LIGASE

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 GLY A 331
GLY A 335
GLU A 334
 None
 0.40A 4z2eA-1mdfA:
0.0
4z2eD-1mdfA:
2.0		 4z2eA-1mdfA:
21.25
4z2eD-1mdfA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhs PLASMA MEMBRANE
ATPASE

(Neurospora
crassa) 		PF00122
(E1-E2_ATPase)
PF00690
(Cation_ATPase_N)
PF00702
(Hydrolase) 		3 GLY A 594
GLY A 589
GLU A 609
 None
 0.49A 4z2eA-1mhsA:
0.0
4z2eD-1mhsA:
undetectable		 4z2eA-1mhsA:
21.31
4z2eD-1mhsA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o3t CATABOLITE GENE
ACTIVATOR PROTEIN

(Escherichia
coli) 		PF00027
(cNMP_binding)
PF00325
(Crp) 		3 GLY A  74
GLY A  79
GLU A  78
 CMP  A 762 ( 4.9A)
None
None
 0.51A 4z2eA-1o3tA:
undetectable
4z2eD-1o3tA:
undetectable		 4z2eA-1o3tA:
17.25
4z2eD-1o3tA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qvr CLPB PROTEIN

(Thermus
thermophilus) 		PF00004
(AAA)
PF02861
(Clp_N)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		3 GLY A 226
GLY A 223
GLU A 222
 None
 0.42A 4z2eA-1qvrA:
undetectable
4z2eD-1qvrA:
undetectable		 4z2eA-1qvrA:
21.21
4z2eD-1qvrA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 GLY A 372
GLY A 370
GLU A 368
 None
 0.48A 4z2eA-1snxA:
3.7
4z2eD-1snxA:
undetectable		 4z2eA-1snxA:
19.92
4z2eD-1snxA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t47 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE

(Streptomyces
avermitilis) 		PF00903
(Glyoxalase) 		3 GLY A 267
GLY A 265
GLU A 193
 None
 0.51A 4z2eA-1t47A:
undetectable
4z2eD-1t47A:
undetectable		 4z2eA-1t47A:
21.22
4z2eD-1t47A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1to6 GLYCERATE KINASE

(Neisseria
meningitidis) 		PF02595
(Gly_kinase) 		3 GLY A  42
GLY A  45
GLU A  87
 None
 0.43A 4z2eA-1to6A:
undetectable
4z2eD-1to6A:
undetectable		 4z2eA-1to6A:
20.24
4z2eD-1to6A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tvc METHANE
MONOOXYGENASE
COMPONENT C

(Methylococcus
capsulatus) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		3 GLY A 126
GLY A 192
GLU A 191
 None
 0.52A 4z2eA-1tvcA:
undetectable
4z2eD-1tvcA:
2.7		 4z2eA-1tvcA:
18.46
4z2eD-1tvcA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlm SAM-DEPENDENT
METHYLTRANSFERASE

(Thermotoga
maritima) 		PF08241
(Methyltransf_11) 		3 GLY A 193
GLY A 195
GLU A 196
 None
 0.51A 4z2eA-1vlmA:
undetectable
4z2eD-1vlmA:
undetectable		 4z2eA-1vlmA:
18.20
4z2eD-1vlmA:
26.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vzo RIBOSOMAL PROTEIN S6
KINASE ALPHA 5

(Homo sapiens) 		PF00069
(Pkinase) 		3 GLY A  56
GLY A  58
GLU A 138
 None
 0.29A 4z2eA-1vzoA:
undetectable
4z2eD-1vzoA:
undetectable		 4z2eA-1vzoA:
23.15
4z2eD-1vzoA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1weh CONSERVED
HYPOTHETICAL PROTEIN
TT1887

(Thermus
thermophilus) 		PF03641
(Lysine_decarbox) 		3 GLY A 106
GLY A 109
GLU A 113
 None
 0.48A 4z2eA-1wehA:
undetectable
4z2eD-1wehA:
undetectable		 4z2eA-1wehA:
16.46
4z2eD-1wehA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xoc OLIGOPEPTIDE-BINDING
PROTEIN APPA

(Bacillus
subtilis) 		PF00496
(SBP_bac_5) 		3 GLY A 439
GLY A 120
GLU A 124
 None
 0.47A 4z2eA-1xocA:
4.4
4z2eD-1xocA:
undetectable		 4z2eA-1xocA:
20.72
4z2eD-1xocA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fek LOW MOLECULAR WEIGHT
PROTEIN-TYROSINE-PHO
SPHATASE WZB

(Escherichia
coli) 		PF01451
(LMWPc) 		3 GLY A  44
GLY A  62
GLU A  61
 None
 0.46A 4z2eA-2fekA:
undetectable
4z2eD-2fekA:
3.0		 4z2eA-2fekA:
16.45
4z2eD-2fekA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g29 NITRATE TRANSPORT
PROTEIN NRTA

(Synechocystis
sp.) 		PF13379
(NMT1_2) 		3 GLY A 156
GLY A 154
GLU A 268
 None
 0.51A 4z2eA-2g29A:
undetectable
4z2eD-2g29A:
undetectable		 4z2eA-2g29A:
24.19
4z2eD-2g29A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iaa AZURIN

(Alcaligenes
faecalis) 		PF00127
(Copper-bind) 		3 GLY C  37
GLY C   9
GLU C   8
 None
 0.49A 4z2eA-2iaaC:
undetectable
4z2eD-2iaaC:
undetectable		 4z2eA-2iaaC:
13.78
4z2eD-2iaaC:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ie8 PHOSPHOGLYCERATE
KINASE

(Thermus
caldophilus) 		PF00162
(PGK) 		3 GLY A 144
GLY A 371
GLU A 375
 None
 0.52A 4z2eA-2ie8A:
undetectable
4z2eD-2ie8A:
undetectable		 4z2eA-2ie8A:
23.67
4z2eD-2ie8A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jg2 SERINE
PALMITOYLTRANSFERASE

(Sphingomonas
paucimobilis) 		PF00155
(Aminotran_1_2) 		3 GLY A 237
GLY A 245
GLU A 248
 None
 0.48A 4z2eA-2jg2A:
undetectable
4z2eD-2jg2A:
undetectable		 4z2eA-2jg2A:
25.00
4z2eD-2jg2A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kik ARTIFICIAL DIIRON
PROTEIN

(-) 		no annotation 3 GLY A   9
GLY A  13
GLU A  36
 None
None
ZN  A  50 ( 2.5A)
 0.36A 4z2eA-2kikA:
undetectable
4z2eD-2kikA:
undetectable		 4z2eA-2kikA:
8.56
4z2eD-2kikA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nxf PUTATIVE DIMETAL
PHOSPHATASE

(Danio rerio) 		PF00149
(Metallophos) 		3 GLY A 269
GLY A 285
GLU A 288
 None
 0.41A 4z2eA-2nxfA:
undetectable
4z2eD-2nxfA:
undetectable		 4z2eA-2nxfA:
21.87
4z2eD-2nxfA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00106
(adh_short)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 GLY A1023
GLY A1227
GLU A1681
 None
 0.49A 4z2eA-2pffA:
undetectable
4z2eD-2pffA:
2.9		 4z2eA-2pffA:
13.71
4z2eD-2pffA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1y CELL DIVISION
PROTEIN FTSZ

(Mycobacterium
tuberculosis) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		3 GLY A 105
GLY A 103
GLU A 102
 GSP  A 401 (-3.6A)
GSP  A 401 ( 4.4A)
None
 0.35A 4z2eA-2q1yA:
undetectable
4z2eD-2q1yA:
3.3		 4z2eA-2q1yA:
22.18
4z2eD-2q1yA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v1u CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG

(Aeropyrum
pernix) 		PF09079
(Cdc6_C)
PF13191
(AAA_16) 		3 GLY A  66
GLY A 252
GLU A 250
 ADP  A1400 (-3.8A)
None
None
 0.49A 4z2eA-2v1uA:
4.3
4z2eD-2v1uA:
undetectable		 4z2eA-2v1uA:
24.22
4z2eD-2v1uA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v6e PROTELEMORASE

(Klebsiella
phage phiKO2) 		PF16684
(Telomere_res) 		3 GLY A 307
GLY A 297
GLU A 284
 None
 0.39A 4z2eA-2v6eA:
undetectable
4z2eD-2v6eA:
undetectable		 4z2eA-2v6eA:
21.28
4z2eD-2v6eA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Mycobacterium
tuberculosis) 		PF00342
(PGI) 		3 GLY A 550
GLY A 553
GLU A 555
 None
 0.49A 4z2eA-2wu8A:
undetectable
4z2eD-2wu8A:
2.3		 4z2eA-2wu8A:
22.20
4z2eD-2wu8A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x8u SERINE
PALMITOYLTRANSFERASE

(Sphingomonas
wittichii) 		PF00155
(Aminotran_1_2) 		3 GLY A 217
GLY A 225
GLU A 228
 None
 0.48A 4z2eA-2x8uA:
undetectable
4z2eD-2x8uA:
undetectable		 4z2eA-2x8uA:
23.83
4z2eD-2x8uA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y4l MANNOSYLGLYCERATE
SYNTHASE

(Rhodothermus
marinus) 		no annotation 3 GLY A  77
GLY A 190
GLU A 232
 None
 0.48A 4z2eA-2y4lA:
undetectable
4z2eD-2y4lA:
undetectable		 4z2eA-2y4lA:
22.07
4z2eD-2y4lA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yrv AT-RICH INTERACTIVE
DOMAIN-CONTAINING
PROTEIN 4A

(Homo sapiens) 		PF08169
(RBB1NT) 		3 GLY A 117
GLY A 113
GLU A 111
 None
 0.50A 4z2eA-2yrvA:
undetectable
4z2eD-2yrvA:
undetectable		 4z2eA-2yrvA:
12.99
4z2eD-2yrvA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3baz HYDROXYPHENYLPYRUVAT
E REDUCTASE

(Plectranthus
scutellarioides) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		3 GLY A 231
GLY A 233
GLU A 261
 NAP  A 500 (-3.8A)
None
None
 0.51A 4z2eA-3bazA:
undetectable
4z2eD-3bazA:
undetectable		 4z2eA-3bazA:
21.77
4z2eD-3bazA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bf0 PROTEASE 4

(Escherichia
coli) 		PF01343
(Peptidase_S49) 		3 GLY A 335
GLY A 345
GLU A 342
 None
 0.46A 4z2eA-3bf0A:
undetectable
4z2eD-3bf0A:
undetectable		 4z2eA-3bf0A:
21.96
4z2eD-3bf0A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqh PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA/MSRB

(Neisseria
meningitidis) 		PF01625
(PMSR) 		3 GLY A 210
GLY A 206
GLU A 250
 None
 0.49A 4z2eA-3bqhA:
undetectable
4z2eD-3bqhA:
undetectable		 4z2eA-3bqhA:
17.78
4z2eD-3bqhA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dgt ENDO-1,3-BETA-GLUCAN
ASE

(Streptomyces
sioyaensis) 		PF00722
(Glyco_hydro_16) 		3 GLY A 141
GLY A 162
GLU A 171
 None
 0.52A 4z2eA-3dgtA:
undetectable
4z2eD-3dgtA:
undetectable		 4z2eA-3dgtA:
18.35
4z2eD-3dgtA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hf8 TRYPTOPHAN
5-HYDROXYLASE 1

(Homo sapiens) 		PF00351
(Biopterin_H) 		3 GLY A 276
GLY A 333
GLU A 317
 None
ML0  A 401 (-3.9A)
FE  A 400 ( 1.9A)
 0.46A 4z2eA-3hf8A:
undetectable
4z2eD-3hf8A:
undetectable		 4z2eA-3hf8A:
20.39
4z2eD-3hf8A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hks EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5A-2

(Arabidopsis
thaliana) 		PF01287
(eIF-5a) 		3 GLY A 158
GLY A 156
GLU A 154
 None
 0.52A 4z2eA-3hksA:
undetectable
4z2eD-3hksA:
undetectable		 4z2eA-3hksA:
16.12
4z2eD-3hksA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3if9 GLYCINE OXIDASE

(Bacillus
subtilis) 		PF01266
(DAO) 		3 GLY A  40
GLY A  36
GLU A 170
 None
 0.38A 4z2eA-3if9A:
undetectable
4z2eD-3if9A:
undetectable		 4z2eA-3if9A:
22.85
4z2eD-3if9A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kst ENDO-1,4-BETA-XYLANA
SE

(Bacteroides
thetaiotaomicron) 		PF04616
(Glyco_hydro_43) 		3 GLY A  66
GLY A  73
GLU A  72
 None
 0.51A 4z2eA-3kstA:
undetectable
4z2eD-3kstA:
undetectable		 4z2eA-3kstA:
21.46
4z2eD-3kstA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l0o TRANSCRIPTION
TERMINATION FACTOR
RHO

(Thermotoga
maritima) 		PF00006
(ATP-synt_ab)
PF07497
(Rho_RNA_bind)
PF07498
(Rho_N) 		3 GLY A  70
GLY A  68
GLU A  67
 None
 0.41A 4z2eA-3l0oA:
undetectable
4z2eD-3l0oA:
undetectable		 4z2eA-3l0oA:
22.28
4z2eD-3l0oA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4k DNA TOPOISOMERASE 2

(Saccharomyces
cerevisiae) 		PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF16898
(TOPRIM_C) 		3 GLY A 450
GLY A 476
GLU A 494
 None
 0.50A 4z2eA-3l4kA:
25.7
4z2eD-3l4kA:
18.3		 4z2eA-3l4kA:
19.58
4z2eD-3l4kA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l76 ASPARTOKINASE

(Synechocystis
sp. PCC 6803) 		PF00696
(AA_kinase)
PF01842
(ACT)
PF13840
(ACT_7) 		3 GLY A 362
GLY A 263
GLU A 265
 None
 0.31A 4z2eA-3l76A:
4.0
4z2eD-3l76A:
2.2		 4z2eA-3l76A:
21.97
4z2eD-3l76A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldr FRUCTOSYLTRANSFERASE

(Aspergillus
japonicus) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		3 GLY A 344
GLY A 349
GLU A 348
 None
 0.49A 4z2eA-3ldrA:
undetectable
4z2eD-3ldrA:
undetectable		 4z2eA-3ldrA:
21.57
4z2eD-3ldrA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6r PROPIONYL-COA
CARBOXYLASE, ALPHA
SUBUNIT

(Ruegeria
pomeroyi) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		3 GLY A 479
GLY A 477
GLU A 476
 None
 0.42A 4z2eA-3n6rA:
undetectable
4z2eD-3n6rA:
2.2		 4z2eA-3n6rA:
22.38
4z2eD-3n6rA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o82 PEPTIDE ARYLATION
ENZYME

(Acinetobacter
baumannii) 		PF00501
(AMP-binding) 		3 GLY A 338
GLY A 342
GLU A 341
 HP8  A 601 (-3.5A)
None
HP8  A 601 ( 4.8A)
 0.43A 4z2eA-3o82A:
undetectable
4z2eD-3o82A:
undetectable		 4z2eA-3o82A:
22.39
4z2eD-3o82A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqn CATABOLITE CONTROL
PROTEIN A

(Bacillus
subtilis) 		PF00356
(LacI)
PF13377
(Peripla_BP_3) 		3 GLY A 220
GLY A 227
GLU A 229
 None
 0.51A 4z2eA-3oqnA:
undetectable
4z2eD-3oqnA:
2.6		 4z2eA-3oqnA:
23.11
4z2eD-3oqnA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3orj SUGAR-BINDING
PROTEIN

(Bacteroides
ovatus) 		no annotation 3 GLY A 259
GLY A 261
GLU A 156
 None
 0.50A 4z2eA-3orjA:
undetectable
4z2eD-3orjA:
undetectable		 4z2eA-3orjA:
22.03
4z2eD-3orjA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pie 5'->3'
EXORIBONUCLEASE
(XRN1)

(Kluyveromyces
lactis) 		PF03159
(XRN_N) 		3 GLY A1222
GLY A1224
GLU A 241
 None
 0.48A 4z2eA-3pieA:
undetectable
4z2eD-3pieA:
undetectable		 4z2eA-3pieA:
18.92
4z2eD-3pieA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qt3 PUTATIVE
UNCHARACTERIZED
PROTEIN CPE0426

(Clostridium
perfringens) 		PF06824
(Glyco_hydro_125) 		3 GLY A 215
GLY A 226
GLU A 288
 None
 0.49A 4z2eA-3qt3A:
undetectable
4z2eD-3qt3A:
undetectable		 4z2eA-3qt3A:
22.26
4z2eD-3qt3A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qua PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycolicibacterium
smegmatis) 		PF03641
(Lysine_decarbox) 		3 GLY A 121
GLY A 124
GLU A 128
 None
UNL  A 195 ( 4.7A)
UNL  A 195 ( 4.7A)
 0.51A 4z2eA-3quaA:
undetectable
4z2eD-3quaA:
2.4		 4z2eA-3quaA:
18.36
4z2eD-3quaA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rg2 ENTEROBACTIN
SYNTHASE COMPONENT E
(ENTE),
2,3-DIHYDRO-2,3-DIHY
DROXYBENZOATE
SYNTHETASE,
ISOCHROISMATASE
(ENTB)

(Escherichia
coli) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF13193
(AMP-binding_C) 		3 GLY A 333
GLY A 337
GLU A 336
 SVS  A 698 (-3.8A)
None
SVS  A 698 ( 4.7A)
 0.50A 4z2eA-3rg2A:
undetectable
4z2eD-3rg2A:
undetectable		 4z2eA-3rg2A:
22.15
4z2eD-3rg2A:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4p INTEGRIN ALPHA-4

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		3 GLY A 304
GLY A 336
GLU A 337
 None
 0.52A 4z2eA-3v4pA:
undetectable
4z2eD-3v4pA:
undetectable		 4z2eA-3v4pA:
21.63
4z2eD-3v4pA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vot L-AMINO ACID LIGASE,
BL00235

(Bacillus
licheniformis) 		PF13535
(ATP-grasp_4) 		3 GLY A 226
GLY A 236
GLU A 235
 None
None
CA  A 502 ( 4.4A)
 0.50A 4z2eA-3votA:
2.3
4z2eD-3votA:
2.6		 4z2eA-3votA:
21.03
4z2eD-3votA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vot L-AMINO ACID LIGASE,
BL00235

(Bacillus
licheniformis) 		PF13535
(ATP-grasp_4) 		3 GLY A 236
GLY A 226
GLU A 205
 None
None
ADP  A 501 ( 2.7A)
 0.46A 4z2eA-3votA:
2.3
4z2eD-3votA:
2.6		 4z2eA-3votA:
21.03
4z2eD-3votA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsm OCCLUSION-DERIVED
VIRUS ENVELOPE
PROTEIN E66

(Autographa
californica
multiple
nucleopolyhedrovirus) 		PF04850
(Baculo_E66) 		3 GLY A 332
GLY A 336
GLU A 335
 None
 0.38A 4z2eA-3vsmA:
undetectable
4z2eD-3vsmA:
undetectable		 4z2eA-3vsmA:
21.28
4z2eD-3vsmA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9h ACRIFLAVINE
RESISTANCE PROTEIN B

(Escherichia
coli) 		PF00873
(ACR_tran) 		3 GLY A 957
GLY A 959
GLU A 962
 None
 0.45A 4z2eA-3w9hA:
2.5
4z2eD-3w9hA:
undetectable		 4z2eA-3w9hA:
20.42
4z2eD-3w9hA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wib HALOALKANE
DEHALOGENASE

(Agrobacterium
fabrum) 		PF00561
(Abhydrolase_1) 		3 GLY A  34
GLY A  32
GLU A  30
 None
 0.51A 4z2eA-3wibA:
undetectable
4z2eD-3wibA:
3.3		 4z2eA-3wibA:
21.30
4z2eD-3wibA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana) 		PF00343
(Phosphorylase) 		3 GLY A 360
GLY A 362
GLU A 365
 None
MLR  A 951 (-3.6A)
None
 0.42A 4z2eA-4bqiA:
undetectable
4z2eD-4bqiA:
2.7		 4z2eA-4bqiA:
19.00
4z2eD-4bqiA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4csb VIRULENCE ASSOCIATED
PROTEIN VAPD

(Rhodococcus
hoagii) 		PF05526
(R_equi_Vir) 		3 GLY A  59
GLY A 132
GLU A 134
 None
 0.41A 4z2eA-4csbA:
undetectable
4z2eD-4csbA:
undetectable		 4z2eA-4csbA:
14.83
4z2eD-4csbA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cz1 KYNURENINE
FORMAMIDASE

(Bacillus
anthracis) 		PF04199
(Cyclase) 		3 GLY A 139
GLY A 103
GLU A 102
 None
 0.27A 4z2eA-4cz1A:
undetectable
4z2eD-4cz1A:
undetectable		 4z2eA-4cz1A:
17.96
4z2eD-4cz1A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyw MUTT/NUDIX FAMILY
PROTEIN

(Burkholderia
pseudomallei) 		PF00293
(NUDIX) 		3 GLY A  96
GLY A  61
GLU A  57
 None
 0.43A 4z2eA-4dywA:
undetectable
4z2eD-4dywA:
undetectable		 4z2eA-4dywA:
14.03
4z2eD-4dywA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e6e CELL DIVISION
PROTEIN FTSZ

(Thermobifida
fusca) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		3 GLY A 105
GLY A 103
GLU A 102
 SO4  A 607 (-3.8A)
None
None
 0.37A 4z2eA-4e6eA:
undetectable
4z2eD-4e6eA:
3.2		 4z2eA-4e6eA:
22.91
4z2eD-4e6eA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ggv CYTOCHROME P450
SUPERFAMILY PROTEIN

(Streptomyces
himastatinicus) 		PF00067
(p450) 		3 GLY A 164
GLY A 161
GLU A 160
 None
 0.41A 4z2eA-4ggvA:
undetectable
4z2eD-4ggvA:
undetectable		 4z2eA-4ggvA:
22.62
4z2eD-4ggvA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gwb PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA 3

(Sinorhizobium
meliloti) 		PF01625
(PMSR) 		3 GLY A  14
GLY A  10
GLU A  50
 None
 0.49A 4z2eA-4gwbA:
2.0
4z2eD-4gwbA:
undetectable		 4z2eA-4gwbA:
14.97
4z2eD-4gwbA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ixo NIFS-LIKE PROTEIN

(Rickettsia
africae) 		PF00266
(Aminotran_5) 		3 GLY A 333
GLY A 335
GLU A 338
 None
 0.51A 4z2eA-4ixoA:
undetectable
4z2eD-4ixoA:
undetectable		 4z2eA-4ixoA:
22.74
4z2eD-4ixoA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l0j DNA HELICASE I

(Escherichia
coli) 		no annotation 3 GLY A 625
GLY A 715
GLU A 716
 None
 0.49A 4z2eA-4l0jA:
undetectable
4z2eD-4l0jA:
undetectable		 4z2eA-4l0jA:
20.20
4z2eD-4l0jA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l62 TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		PF00440
(TetR_N)
PF16925
(TetR_C_13) 		3 GLY A  27
GLY A  29
GLU A  32
 None
 0.52A 4z2eA-4l62A:
undetectable
4z2eD-4l62A:
undetectable		 4z2eA-4l62A:
17.00
4z2eD-4l62A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lhe THERMOSTABLE
MONOACYLGLYCEROL
LIPASE

(Bacillus sp.
H-257) 		PF12146
(Hydrolase_4) 		3 GLY A 131
GLY A 134
GLU A 137
 None
 0.43A 4z2eA-4lheA:
undetectable
4z2eD-4lheA:
3.1		 4z2eA-4lheA:
18.20
4z2eD-4lheA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ml9 UNCHARACTERIZED
PROTEIN

(Sebaldella
termitidis) 		PF00977
(His_biosynth) 		3 GLY A 107
GLY A 111
GLU A 114
 None
 0.52A 4z2eA-4ml9A:
undetectable
4z2eD-4ml9A:
2.0		 4z2eA-4ml9A:
20.83
4z2eD-4ml9A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xqe HOMOSPERMIDINE
SYNTHASE

(Blastochloris
viridis) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		3 GLY A 453
GLY A 456
GLU A 460
 None
 0.38A 4z2eA-4xqeA:
undetectable
4z2eD-4xqeA:
undetectable		 4z2eA-4xqeA:
20.52
4z2eD-4xqeA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ymd COLLECTIN-11

(Homo sapiens) 		PF00059
(Lectin_C) 		3 GLY A 249
GLY A 187
GLU A 183
 None
 0.47A 4z2eA-4ymdA:
undetectable
4z2eD-4ymdA:
undetectable		 4z2eA-4ymdA:
15.45
4z2eD-4ymdA:
21.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4z3o DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE

(Streptococcus
pneumoniae) 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim) 		3 GLY A 434
GLY A 457
GLU A 475
 None
 0.17A 4z2eA-4z3oA:
53.7
4z2eD-4z3oA:
25.9		 4z2eA-4z3oA:
35.84
4z2eD-4z3oA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoh PUTATIVE
OXIDOREDUCTASE
IRON-SULFUR SUBUNIT

(Sulfurisphaera
tokodaii) 		PF00111
(Fer2)
PF01799
(Fer2_2) 		3 GLY C 138
GLY C 135
GLU C 134
 None
 0.47A 4z2eA-4zohC:
undetectable
4z2eD-4zohC:
undetectable		 4z2eA-4zohC:
15.57
4z2eD-4zohC:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zyj DNMZ

(Streptomyces
peucetius) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 GLY A  68
GLY A  76
GLU A  73
 None
 0.50A 4z2eA-4zyjA:
undetectable
4z2eD-4zyjA:
undetectable		 4z2eA-4zyjA:
23.64
4z2eD-4zyjA:
26.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e4m HYDROXYNITRILE LYASE

(Davallia
tyermannii) 		no annotation 3 GLY A 133
GLY A 131
GLU A 128
 None
HBA  A 202 ( 4.2A)
None
 0.48A 4z2eA-5e4mA:
undetectable
4z2eD-5e4mA:
undetectable		 4z2eA-5e4mA:
17.53
4z2eD-5e4mA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eod COAGULATION FACTOR
XI

(Homo sapiens) 		PF00024
(PAN_1)
PF00089
(Trypsin) 		3 GLY A 326
GLY A 324
GLU A 323
 None
 0.46A 4z2eA-5eodA:
undetectable
4z2eD-5eodA:
undetectable		 4z2eA-5eodA:
23.04
4z2eD-5eodA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fif CARBOXYLASE

(Deinococcus
radiodurans) 		PF01039
(Carboxyl_trans) 		3 GLY A 187
GLY A 530
GLU A 529
 None
 0.39A 4z2eA-5fifA:
undetectable
4z2eD-5fifA:
undetectable		 4z2eA-5fifA:
22.08
4z2eD-5fifA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fp1 TONB-DEPENDENT
SIDEROPHORE RECEPTOR

(Acinetobacter
baumannii) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 GLY A  72
GLY A  79
GLU A  90
 None
 0.52A 4z2eA-5fp1A:
undetectable
4z2eD-5fp1A:
undetectable		 4z2eA-5fp1A:
21.37
4z2eD-5fp1A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gai TAIL FIBER PROTEIN

(Salmonella
virus P22) 		no annotation 3 GLY Y 178
GLY Y 156
GLU Y 157
 None
 0.52A 4z2eA-5gaiY:
undetectable
4z2eD-5gaiY:
undetectable		 4z2eA-5gaiY:
20.47
4z2eD-5gaiY:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hrj SCAVENGER RECEPTOR
CYSTEINE-RICH TYPE 1
PROTEIN M130

(Sus scrofa) 		PF00530
(SRCR) 		3 GLY A 537
GLY A 499
GLU A 491
 None
 0.46A 4z2eA-5hrjA:
undetectable
4z2eD-5hrjA:
undetectable		 4z2eA-5hrjA:
12.85
4z2eD-5hrjA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5itg SORBITOL
DEHYDROGENASE

(Gluconobacter
oxydans) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		3 GLY A 195
GLY A 226
GLU A 291
 None
 0.48A 4z2eA-5itgA:
undetectable
4z2eD-5itgA:
undetectable		 4z2eA-5itgA:
25.22
4z2eD-5itgA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jk6 PHENYLALANINE-4-HYDR
OXYLASE

(Dictyostelium
discoideum) 		PF00351
(Biopterin_H) 		3 GLY A 277
GLY A 334
GLU A 318
 None
None
FE  A 502 (-2.1A)
 0.48A 4z2eA-5jk6A:
4.2
4z2eD-5jk6A:
undetectable		 4z2eA-5jk6A:
21.77
4z2eD-5jk6A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kei 2,3-DIHYDROXYBENZOAT
E-AMP LIGASE

(Mycolicibacterium
smegmatis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 GLY A 354
GLY A 358
GLU A 357
 None
 0.45A 4z2eA-5keiA:
undetectable
4z2eD-5keiA:
undetectable		 4z2eA-5keiA:
22.78
4z2eD-5keiA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l01 TRYPTOPHAN
5-HYDROXYLASE 1

(Homo sapiens) 		PF00351
(Biopterin_H) 		3 GLY A 276
GLY A 333
GLU A 317
 None
6Z4  A 502 (-3.9A)
FE  A 501 ( 1.8A)
 0.44A 4z2eA-5l01A:
undetectable
4z2eD-5l01A:
undetectable		 4z2eA-5l01A:
21.69
4z2eD-5l01A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l5n PLEXIN-A4

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI)
PF01833
(TIG) 		3 GLY A 867
GLY A 871
GLU A 870
 GLY  A 867 ( 0.0A)
GLY  A 871 ( 0.0A)
GLU  A 870 ( 0.6A)
 0.52A 4z2eA-5l5nA:
undetectable
4z2eD-5l5nA:
undetectable		 4z2eA-5l5nA:
18.05
4z2eD-5l5nA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lj8 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Escherichia
coli) 		no annotation 3 GLY A 321
GLY A 445
GLU A 439
 None
 0.46A 4z2eA-5lj8A:
4.2
4z2eD-5lj8A:
undetectable		 4z2eA-5lj8A:
19.36
4z2eD-5lj8A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nv6 TRANSFORMING GROWTH
FACTOR-BETA-INDUCED
PROTEIN IG-H3

(Homo sapiens) 		PF02469
(Fasciclin) 		3 GLY A 623
GLY A 535
GLU A 534
 None
 0.46A 4z2eA-5nv6A:
undetectable
4z2eD-5nv6A:
undetectable		 4z2eA-5nv6A:
22.78
4z2eD-5nv6A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oex -

(-) 		no annotation 3 GLY A 219
GLY A 221
GLU A 288
 None
None
CU  A 603 ( 4.3A)
 0.49A 4z2eA-5oexA:
undetectable
4z2eD-5oexA:
undetectable		 4z2eA-5oexA:
undetectable
4z2eD-5oexA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5onu OUTER MEMBRANE
PROTEIN OMPU

(Vibrio cholerae) 		no annotation 3 GLY A  93
GLY A 121
GLU A 128
 None
 0.41A 4z2eA-5onuA:
undetectable
4z2eD-5onuA:
undetectable		 4z2eA-5onuA:
11.98
4z2eD-5onuA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5unl 3-KETOACYL-ACP
REDUCTASE

(Burkholderia
multivorans) 		PF13561
(adh_short_C2) 		3 GLY A 211
GLY A 213
GLU A 216
 None
EDO  A 305 (-3.1A)
EDO  A 305 (-3.5A)
 0.48A 4z2eA-5unlA:
undetectable
4z2eD-5unlA:
2.7		 4z2eA-5unlA:
21.39
4z2eD-5unlA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w25 ASPARTATE--TRNA(ASP/
ASN) LIGASE

(Mycobacterium
tuberculosis) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		3 GLY A 489
GLY A 487
GLU A 485
 ASP  A 701 ( 4.0A)
None
None
 0.49A 4z2eA-5w25A:
undetectable
4z2eD-5w25A:
undetectable		 4z2eA-5w25A:
22.02
4z2eD-5w25A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wm4 SALICYLATE-AMP
LIGASE

(Streptomyces
gandocaensis) 		no annotation 3 GLY A 352
GLY A 356
GLU A 355
 B5M  A 601 (-3.8A)
None
B5M  A 601 ( 4.8A)
 0.41A 4z2eA-5wm4A:
undetectable
4z2eD-5wm4A:
undetectable		 4z2eA-5wm4A:
9.40
4z2eD-5wm4A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zbl CYTOKININ RIBOSIDE
5'-MONOPHOSPHATE
PHOSPHORIBOHYDROLASE

(Corynebacterium
glutamicum) 		no annotation 3 GLY A  18
GLY A 118
GLU A 122
 PO4  A 303 (-3.6A)
PO4  A 303 (-3.5A)
None
 0.49A 4z2eA-5zblA:
undetectable
4z2eD-5zblA:
undetectable		 4z2eA-5zblA:
10.68
4z2eD-5zblA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ehc OUTER MEMBRANE
PROTEIN U

(Vibrio cholerae) 		no annotation 3 GLY A  63
GLY A  91
GLU A  98
 None
 0.45A 4z2eA-6ehcA:
undetectable
4z2eD-6ehcA:
undetectable		 4z2eA-6ehcA:
10.06
4z2eD-6ehcA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eqc SCFV OF 9C12
ANTIBODY

(Mus musculus) 		no annotation 3 GLY D 172
GLY D 174
GLU D 176
 None
 0.00A 4z2eA-6eqcD:
undetectable
4z2eD-6eqcD:
undetectable		 4z2eA-6eqcD:
9.21
4z2eD-6eqcD:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f4g PROBABLE U2 SMALL
NUCLEAR
RIBONUCLEOPROTEIN A'

(Drosophila
melanogaster) 		no annotation 3 GLY A 111
GLY A  82
GLU A  81
 None
 0.48A 4z2eA-6f4gA:
undetectable
4z2eD-6f4gA:
undetectable		 4z2eA-6f4gA:
10.39
4z2eD-6f4gA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhw GLUCOAMYLASE P

(Amorphotheca
resinae) 		no annotation 3 GLY A 330
GLY A 328
GLU A 327
 None
 0.48A 4z2eA-6fhwA:
undetectable
4z2eD-6fhwA:
undetectable		 4z2eA-6fhwA:
9.69
4z2eD-6fhwA:
13.75