SIMILAR PATTERNS OF AMINO ACIDS FOR 4Z2D_F_LFXF102

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhy P64K

(Neisseria
meningitidis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 ARG A 153
GLY A 231
GLU A 152
 FAD  A 600 (-3.6A)
None
FAD  A 600 (-2.5A)
 0.65A 4z2dB-1bhyA:
0.0
4z2dC-1bhyA:
undetectable		 4z2dB-1bhyA:
23.61
4z2dC-1bhyA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ci0 PROTEIN (PNP
OXIDASE)

(Saccharomyces
cerevisiae) 		PF01243
(Putative_PNPOx)
PF10590
(PNP_phzG_C) 		3 ARG A  69
GLY A  68
GLU A  64
 None
 0.58A 4z2dB-1ci0A:
0.0
4z2dC-1ci0A:
undetectable		 4z2dB-1ci0A:
18.55
4z2dC-1ci0A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eke RIBONUCLEASE HII

(Methanocaldococcus
jannaschii) 		PF01351
(RNase_HII) 		3 ARG A  11
GLY A  10
GLU A   8
 None
 0.62A 4z2dB-1ekeA:
0.0
4z2dC-1ekeA:
undetectable		 4z2dB-1ekeA:
18.05
4z2dC-1ekeA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		3 ARG A 223
GLY A 224
GLU A 227
 None
 0.45A 4z2dB-1fc4A:
0.1
4z2dC-1fc4A:
undetectable		 4z2dB-1fc4A:
23.38
4z2dC-1fc4A:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gl9 REVERSE GYRASE

(Archaeoglobus
fulgidus) 		PF00270
(DEAD)
PF01131
(Topoisom_bac)
PF01751
(Toprim) 		3 ARG B 968
GLY B 969
GLU B1019
 None
 0.65A 4z2dB-1gl9B:
2.5
4z2dC-1gl9B:
7.8		 4z2dB-1gl9B:
19.81
4z2dC-1gl9B:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1heh ENDO-1,4-BETA-XYLANA
SE D

(Cellulomonas
fimi) 		no annotation 3 ARG C 566
GLY C 567
GLU C 569
 None
 0.66A 4z2dB-1hehC:
undetectable
4z2dC-1hehC:
undetectable		 4z2dB-1hehC:
11.90
4z2dC-1hehC:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iz1 LYSR-TYPE REGULATORY
PROTEIN

(Cupriavidus
necator) 		PF00126
(HTH_1)
PF03466
(LysR_substrate) 		3 ARG A  53
GLY A  54
GLU A  56
 None
 0.67A 4z2dB-1iz1A:
1.5
4z2dC-1iz1A:
undetectable		 4z2dB-1iz1A:
20.52
4z2dC-1iz1A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5j ACONITATE HYDRATASE
2

(Escherichia
coli) 		PF00330
(Aconitase)
PF06434
(Aconitase_2_N)
PF11791
(Aconitase_B_N) 		3 ARG A 535
GLY A 583
GLU A 582
 None
 0.66A 4z2dB-1l5jA:
0.2
4z2dC-1l5jA:
undetectable		 4z2dB-1l5jA:
21.80
4z2dC-1l5jA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1msk COBALAMIN-DEPENDENT
METHIONINE SYNTHASE

(Escherichia
coli) 		PF02965
(Met_synt_B12) 		3 ARG A 996
GLY A 997
GLU A 935
 None
 0.66A 4z2dB-1mskA:
0.0
4z2dC-1mskA:
undetectable		 4z2dB-1mskA:
22.38
4z2dC-1mskA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rvf FAB 17-IA

(Mus musculus) 		PF07686
(V-set) 		3 ARG H  40
GLY H  44
GLU H  46
 None
 0.64A 4z2dB-1rvfH:
undetectable
4z2dC-1rvfH:
undetectable		 4z2dB-1rvfH:
11.52
4z2dC-1rvfH:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t5i C_TERMINAL DOMAIN OF
A PROBABLE
ATP-DEPENDENT RNA
HELICASE

(Homo sapiens) 		PF00271
(Helicase_C) 		3 ARG A 377
GLY A 379
GLU A 354
 None
 0.68A 4z2dB-1t5iA:
undetectable
4z2dC-1t5iA:
undetectable		 4z2dB-1t5iA:
16.39
4z2dC-1t5iA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v19 2-KETO-3-DEOXYGLUCON
ATE KINASE

(Thermus
thermophilus) 		PF00294
(PfkB) 		3 ARG A 100
GLY A  99
GLU A  92
 None
 0.59A 4z2dB-1v19A:
undetectable
4z2dC-1v19A:
undetectable		 4z2dB-1v19A:
21.31
4z2dC-1v19A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdi HYPOTHETICAL PROTEIN
TT0907

(Thermus
thermophilus) 		PF02547
(Queuosine_synth) 		3 ARG A  24
GLY A  20
GLU A  22
 None
 0.65A 4z2dB-1wdiA:
undetectable
4z2dC-1wdiA:
undetectable		 4z2dB-1wdiA:
22.54
4z2dC-1wdiA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9d ENDOPLASMIC
RETICULUM
MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E

(Homo sapiens) 		PF01532
(Glyco_hydro_47) 		3 ARG A 495
GLY A 493
GLU A 492
 None
 0.56A 4z2dB-1x9dA:
undetectable
4z2dC-1x9dA:
undetectable		 4z2dB-1x9dA:
22.46
4z2dC-1x9dA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xf1 C5A PEPTIDASE

(Streptococcus
pyogenes) 		PF00082
(Peptidase_S8)
PF02225
(PA)
PF06280
(fn3_5)
PF13585
(CHU_C) 		3 ARG A 214
GLY A 217
GLU A 216
 None
 0.65A 4z2dB-1xf1A:
undetectable
4z2dC-1xf1A:
undetectable		 4z2dB-1xf1A:
20.00
4z2dC-1xf1A:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xv5 DNA
ALPHA-GLUCOSYLTRANSF
ERASE

(Escherichia
virus T4) 		PF11440
(AGT) 		3 ARG A1204
GLY A1233
GLU A1235
 CME  A1014 (-3.7A)
UDP  A1402 ( 3.9A)
None
 0.44A 4z2dB-1xv5A:
undetectable
4z2dC-1xv5A:
2.4		 4z2dB-1xv5A:
23.12
4z2dC-1xv5A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a6p POSSIBLE
PHOSPHOGLYCERATE
MUTASE GPM2

(Mycobacterium
tuberculosis) 		PF00300
(His_Phos_1) 		3 ARG A 168
GLY A 166
GLU A 165
 None
 0.57A 4z2dB-2a6pA:
undetectable
4z2dC-2a6pA:
undetectable		 4z2dB-2a6pA:
18.85
4z2dC-2a6pA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ab4 TRNA PSEUDOURIDINE
SYNTHASE B

(Thermotoga
maritima) 		PF01472
(PUA)
PF01509
(TruB_N)
PF16198
(TruB_C_2) 		3 ARG A  72
GLY A  74
GLU A  89
 None
 0.57A 4z2dB-2ab4A:
undetectable
4z2dC-2ab4A:
undetectable		 4z2dB-2ab4A:
22.64
4z2dC-2ab4A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buj SERINE/THREONINE-PRO
TEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		3 ARG A 134
GLY A 135
GLU A 137
 None
 0.60A 4z2dB-2bujA:
undetectable
4z2dC-2bujA:
undetectable		 4z2dB-2bujA:
20.88
4z2dC-2bujA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c0l PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR

(Homo sapiens) 		PF00515
(TPR_1)
PF13432
(TPR_16) 		3 ARG A 345
GLY A 349
GLU A 348
 None
 0.60A 4z2dB-2c0lA:
undetectable
4z2dC-2c0lA:
undetectable		 4z2dB-2c0lA:
22.05
4z2dC-2c0lA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cff 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)
METHYLIDENEAMINO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE

(Thermotoga
maritima) 		PF00977
(His_biosynth) 		3 ARG A  11
GLY A  12
GLU A  61
 None
 0.66A 4z2dB-2cffA:
undetectable
4z2dC-2cffA:
undetectable		 4z2dB-2cffA:
19.48
4z2dC-2cffA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dru CHIMERA OF CD48
ANTIGEN AND T-CELL
SURFACE ANTIGEN CD2

(Rattus
norvegicus) 		PF05790
(C2-set)
PF07686
(V-set) 		3 ARG A  81
GLY A  82
GLU A 101
 GOL  A 702 (-3.4A)
None
GOL  A 703 (-4.0A)
 0.67A 4z2dB-2druA:
undetectable
4z2dC-2druA:
undetectable		 4z2dB-2druA:
15.51
4z2dC-2druA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e8m EPIDERMAL GROWTH
FACTOR RECEPTOR
KINASE SUBSTRATE 8

(Homo sapiens) 		no annotation 3 ARG A  81
GLY A  79
GLU A  78
 None
 0.61A 4z2dB-2e8mA:
undetectable
4z2dC-2e8mA:
undetectable		 4z2dB-2e8mA:
14.65
4z2dC-2e8mA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ec7 GAG POLYPROTEIN
(PR55GAG)

(Human
immunodeficiency
virus 2) 		PF00098
(zf-CCHC) 		3 ARG A   8
GLY A  13
GLU A  15
 None
 0.61A 4z2dB-2ec7A:
undetectable
4z2dC-2ec7A:
undetectable		 4z2dB-2ec7A:
5.56
4z2dC-2ec7A:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR

(Escherichia
coli) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02559
(CarD_CdnL_TRCF)
PF03461
(TRCF) 		3 ARG A 395
GLY A 393
GLU A 392
 SO4  A1150 (-3.3A)
None
None
 0.58A 4z2dB-2eyqA:
undetectable
4z2dC-2eyqA:
3.4		 4z2dB-2eyqA:
19.44
4z2dC-2eyqA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f8t ARGONAUTE PROTEIN

(Aquifex
aeolicus) 		PF02171
(Piwi) 		3 ARG A 573
GLY A 572
GLU A 597
 None
 0.56A 4z2dB-2f8tA:
undetectable
4z2dC-2f8tA:
2.1		 4z2dB-2f8tA:
22.07
4z2dC-2f8tA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gv8 MONOOXYGENASE

(Schizosaccharomyces
pombe) 		PF00743
(FMO-like)
PF13450
(NAD_binding_8) 		3 ARG A  40
GLY A  41
GLU A  38
 FAD  A 500 (-4.0A)
None
FAD  A 500 (-2.5A)
 0.67A 4z2dB-2gv8A:
undetectable
4z2dC-2gv8A:
undetectable		 4z2dB-2gv8A:
22.04
4z2dC-2gv8A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0m PHOSPHATE TRANSPORT
SYSTEM PROTEIN PHOU

(Streptococcus
pneumoniae) 		PF01895
(PhoU) 		3 ARG A 192
GLY A 188
GLU A 191
 None
None
ZN  A 217 (-2.9A)
 0.64A 4z2dB-2i0mA:
0.8
4z2dC-2i0mA:
undetectable		 4z2dB-2i0mA:
18.59
4z2dC-2i0mA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2joz HYPOTHETICAL PROTEIN
YXEF

(Bacillus
subtilis) 		PF11631
(DUF3255) 		3 ARG A  25
GLY A  24
GLU A  23
 None
 0.68A 4z2dB-2jozA:
undetectable
4z2dC-2jozA:
undetectable		 4z2dB-2jozA:
15.23
4z2dC-2jozA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lvg NON-STRUCTURAL
PROTEIN 4B

(Hepacivirus C) 		no annotation 3 ARG A  12
GLY A  10
GLU A   8
 None
 0.63A 4z2dB-2lvgA:
undetectable
4z2dC-2lvgA:
undetectable		 4z2dB-2lvgA:
7.42
4z2dC-2lvgA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lw7 HISTIDINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF00458
(WHEP-TRS)
PF03129
(HGTP_anticodon) 		3 ARG A  16
GLY A  14
GLU A  33
 None
 0.66A 4z2dB-2lw7A:
undetectable
4z2dC-2lw7A:
undetectable		 4z2dB-2lw7A:
16.80
4z2dC-2lw7A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyf T-CELL RECEPTOR,
BETA CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 ARG B 239
GLY B 238
GLU B 126
 None
 0.64A 4z2dB-2pyfB:
undetectable
4z2dC-2pyfB:
undetectable		 4z2dB-2pyfB:
19.96
4z2dC-2pyfB:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		3 ARG A 181
GLY A 183
GLU A 180
 None
 0.63A 4z2dB-2r3aA:
undetectable
4z2dC-2r3aA:
undetectable		 4z2dB-2r3aA:
19.76
4z2dC-2r3aA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vg9 BIFUNCTIONAL
ENDO-1,4-BETA-XYLANA
SE A

(Neocallimastix
patriciarum) 		PF00457
(Glyco_hydro_11) 		3 ARG A  56
GLY A  58
GLU A 193
 None
 0.58A 4z2dB-2vg9A:
undetectable
4z2dC-2vg9A:
undetectable		 4z2dB-2vg9A:
17.59
4z2dC-2vg9A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vyw HEMOGLOBIN

(Fasciola
hepatica) 		PF00042
(Globin) 		3 ARG A  65
GLY A  63
GLU A  62
 None
 0.67A 4z2dB-2vywA:
undetectable
4z2dC-2vywA:
undetectable		 4z2dB-2vywA:
16.91
4z2dC-2vywA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxz THIAMIN-MONOPHOSPHAT
E KINASE

(Thermus
thermophilus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		3 ARG A 175
GLY A 174
GLU A 173
 None
 0.58A 4z2dB-2yxzA:
undetectable
4z2dC-2yxzA:
undetectable		 4z2dB-2yxzA:
20.75
4z2dC-2yxzA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ze5 ISOPENTENYL
TRANSFERASE

(Agrobacterium
tumefaciens) 		PF01745
(IPT) 		3 ARG A  87
GLY A  92
GLU A  90
 None
 0.68A 4z2dB-2ze5A:
undetectable
4z2dC-2ze5A:
undetectable		 4z2dB-2ze5A:
18.50
4z2dC-2ze5A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zi8 PROBABLE
BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE BPHC

(Mycobacterium
tuberculosis) 		PF00903
(Glyoxalase) 		3 ARG A  10
GLY A  65
GLU A 116
 None
 0.59A 4z2dB-2zi8A:
undetectable
4z2dC-2zi8A:
undetectable		 4z2dB-2zi8A:
21.82
4z2dC-2zi8A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zj8 PUTATIVE SKI2-TYPE
HELICASE

(Pyrococcus
furiosus) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF14520
(HHH_5) 		3 ARG A  97
GLY A  95
GLU A  92
 None
 0.61A 4z2dB-2zj8A:
1.9
4z2dC-2zj8A:
2.4		 4z2dB-2zj8A:
21.22
4z2dC-2zj8A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bt5 UNCHARACTERIZED
PROTEIN DUF305

(Deinococcus
radiodurans) 		PF03713
(DUF305) 		3 ARG A 170
GLY A 174
GLU A 173
 None
 0.64A 4z2dB-3bt5A:
undetectable
4z2dC-3bt5A:
undetectable		 4z2dB-3bt5A:
15.06
4z2dC-3bt5A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c6m SPERMINE SYNTHASE

(Homo sapiens) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		3 ARG A 268
GLY A 267
GLU A 266
 None
 0.59A 4z2dB-3c6mA:
undetectable
4z2dC-3c6mA:
2.4		 4z2dB-3c6mA:
22.05
4z2dC-3c6mA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF06421
(LepA_C) 		3 ARG C 507
GLY C 508
GLU C 510
 None
 0.68A 4z2dB-3degC:
undetectable
4z2dC-3degC:
2.3		 4z2dB-3degC:
24.27
4z2dC-3degC:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fp9 PROTEASOME-ASSOCIATE
D ATPASE

(Mycobacterium
tuberculosis) 		PF16450
(Prot_ATP_ID_OB) 		3 ARG A 184
GLY A 178
GLU A 160
 None
 0.68A 4z2dB-3fp9A:
undetectable
4z2dC-3fp9A:
undetectable		 4z2dB-3fp9A:
15.60
4z2dC-3fp9A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8q PREDICTED
RNA-BINDING PROTEIN,
CONTAINS THUMP
DOMAIN

(Methanopyrus
kandleri) 		PF00383
(dCMP_cyt_deam_1)
PF02926
(THUMP) 		3 ARG A 191
GLY A 274
GLU A 276
 NA  A 302 (-4.0A)
None
None
 0.59A 4z2dB-3g8qA:
undetectable
4z2dC-3g8qA:
undetectable		 4z2dB-3g8qA:
21.58
4z2dC-3g8qA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihg RDME

(Streptomyces
purpurascens) 		PF01494
(FAD_binding_3) 		3 ARG A  36
GLY A 140
GLU A  35
 FAD  A 536 (-4.1A)
None
FAD  A 536 (-2.9A)
 0.65A 4z2dB-3ihgA:
undetectable
4z2dC-3ihgA:
undetectable		 4z2dB-3ihgA:
23.58
4z2dC-3ihgA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m3w PROTEIN KINASE C AND
CASEIN KINASE II
SUBSTRATE PROTEIN 3

(Mus musculus) 		PF00611
(FCH) 		3 ARG A  34
GLY A  32
GLU A  30
 None
 0.55A 4z2dB-3m3wA:
0.6
4z2dC-3m3wA:
undetectable		 4z2dB-3m3wA:
21.58
4z2dC-3m3wA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3t PUTATIVE DIGUANYLATE
CYCLASE/PHOSPHODIEST
ERASE

(Thiobacillus
denitrificans) 		PF00563
(EAL) 		3 ARG A 642
GLY A 665
GLU A 699
 None
 0.68A 4z2dB-3n3tA:
undetectable
4z2dC-3n3tA:
undetectable		 4z2dB-3n3tA:
19.81
4z2dC-3n3tA:
26.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3na6 SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE

(Ruegeria sp.
TM1040) 		PF04952
(AstE_AspA) 		3 ARG A 291
GLY A 293
GLU A 294
 None
 0.63A 4z2dB-3na6A:
undetectable
4z2dC-3na6A:
3.5		 4z2dB-3na6A:
20.27
4z2dC-3na6A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nbm PTS SYSTEM,
LACTOSE-SPECIFIC
IIBC COMPONENTS

(Streptococcus
pneumoniae) 		PF02302
(PTS_IIB) 		3 ARG A 534
GLY A 535
GLU A 537
 None
 0.65A 4z2dB-3nbmA:
undetectable
4z2dC-3nbmA:
3.3		 4z2dB-3nbmA:
12.90
4z2dC-3nbmA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o6p PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Enterococcus
faecalis) 		PF00496
(SBP_bac_5) 		3 ARG A 476
GLY A 477
GLU A 307
 None
 0.47A 4z2dB-3o6pA:
undetectable
4z2dC-3o6pA:
undetectable		 4z2dB-3o6pA:
19.11
4z2dC-3o6pA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p9v UNCHARACTERIZED
PROTEIN

(Marinobacter
hydrocarbonoclasticus) 		PF10604
(Polyketide_cyc2) 		3 ARG A  51
GLY A  90
GLU A  89
 None
 0.67A 4z2dB-3p9vA:
undetectable
4z2dC-3p9vA:
undetectable		 4z2dB-3p9vA:
15.63
4z2dC-3p9vA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pwz SHIKIMATE
DEHYDROGENASE 3

(Pseudomonas
putida) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		3 ARG A  10
GLY A   9
GLU A  38
 None
 0.66A 4z2dB-3pwzA:
undetectable
4z2dC-3pwzA:
2.5		 4z2dB-3pwzA:
22.09
4z2dC-3pwzA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qpi CHLORITE DISMUTASE

(Nitrobacter
winogradskyi) 		PF06778
(Chlor_dismutase) 		3 ARG A  53
GLY A  54
GLU A 137
 None
 0.67A 4z2dB-3qpiA:
undetectable
4z2dC-3qpiA:
undetectable		 4z2dB-3qpiA:
18.04
4z2dC-3qpiA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sju KETO REDUCTASE

(Streptomyces
griseoruber) 		PF00106
(adh_short) 		3 ARG A 130
GLY A 127
GLU A 131
 None
 0.61A 4z2dB-3sjuA:
undetectable
4z2dC-3sjuA:
2.6		 4z2dB-3sjuA:
21.41
4z2dC-3sjuA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3snx PUTATIVE SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 ARG A 329
GLY A 331
GLU A 330
 None
 0.65A 4z2dB-3snxA:
0.0
4z2dC-3snxA:
undetectable		 4z2dB-3snxA:
21.14
4z2dC-3snxA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6s CERJ

(Streptomyces
tendae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		3 ARG A 268
GLY A 271
GLU A 273
 None
 0.58A 4z2dB-3t6sA:
undetectable
4z2dC-3t6sA:
undetectable		 4z2dB-3t6sA:
24.06
4z2dC-3t6sA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va9 SENSOR HISTIDINE
KINASE

(Rhodopseudomonas
palustris) 		PF05227
(CHASE3) 		3 ARG A  71
GLY A  72
GLU A  70
 None
 0.46A 4z2dB-3va9A:
undetectable
4z2dC-3va9A:
undetectable		 4z2dB-3va9A:
18.24
4z2dC-3va9A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE

(Trypanosoma
brucei) 		PF01704
(UDPGP) 		3 ARG A 308
GLY A 309
GLU A 312
 None
 0.56A 4z2dB-4bqhA:
undetectable
4z2dC-4bqhA:
undetectable		 4z2dB-4bqhA:
22.85
4z2dC-4bqhA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jq9 DIHYDROLIPOYL
DEHYDROGENASE

(Escherichia
coli) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 ARG A  37
GLY A 115
GLU A  36
 FAD  A 512 (-3.7A)
None
FAD  A 512 (-2.6A)
 0.54A 4z2dB-4jq9A:
undetectable
4z2dC-4jq9A:
undetectable		 4z2dB-4jq9A:
23.82
4z2dC-4jq9A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k7g 3-HYDROXYPROLINE
DEHYDRATSE

(Agrobacterium
vitis) 		PF05544
(Pro_racemase) 		3 ARG B 253
GLY B  16
GLU B  17
 None
None
PYC  B 904 (-4.5A)
 0.67A 4z2dB-4k7gB:
undetectable
4z2dC-4k7gB:
undetectable		 4z2dB-4k7gB:
22.52
4z2dC-4k7gB:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k9q BENZOYLFORMATE
DECARBOXYLASE

(Polynucleobacter
necessarius) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 ARG A 419
GLY A 418
GLU A 414
 None
 0.52A 4z2dB-4k9qA:
undetectable
4z2dC-4k9qA:
undetectable		 4z2dB-4k9qA:
23.49
4z2dC-4k9qA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kh7 GLUTATHIONE
S-TRANSFERASE FAMILY
PROTEIN

(Salmonella
enterica) 		PF02798
(GST_N)
PF13410
(GST_C_2) 		3 ARG A  92
GLY A  95
GLU A  96
 None
 0.64A 4z2dB-4kh7A:
undetectable
4z2dC-4kh7A:
undetectable		 4z2dB-4kh7A:
18.00
4z2dC-4kh7A:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ksa MALONYL-COA
DECARBOXYLASE

(Rhodopseudomonas
palustris) 		PF05292
(MCD)
PF17408
(MCD_N) 		3 ARG A 119
GLY A 115
GLU A 116
 None
 0.66A 4z2dB-4ksaA:
undetectable
4z2dC-4ksaA:
undetectable		 4z2dB-4ksaA:
23.98
4z2dC-4ksaA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lej VICILIN

(Pinus
koraiensis) 		PF00190
(Cupin_1) 		3 ARG A 431
GLY A 432
GLU A 434
 None
 0.65A 4z2dB-4lejA:
undetectable
4z2dC-4lejA:
undetectable		 4z2dB-4lejA:
22.44
4z2dC-4lejA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxi MCP HYDROLASE

(Sphingomonas
wittichii) 		PF12697
(Abhydrolase_6) 		3 ARG A 160
GLY A 158
GLU A 157
 None
 0.63A 4z2dB-4lxiA:
undetectable
4z2dC-4lxiA:
3.0		 4z2dB-4lxiA:
19.84
4z2dC-4lxiA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m4z SRC-LIKE-ADAPTER 2

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1) 		3 ARG A  54
GLY A  56
GLU A  57
 None
 0.52A 4z2dB-4m4zA:
undetectable
4z2dC-4m4zA:
undetectable		 4z2dB-4m4zA:
16.38
4z2dC-4m4zA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mag SIALIC ACID BINDING
PROTEIN

(Vibrio cholerae) 		PF03480
(DctP) 		3 ARG A  69
GLY A  68
GLU A  66
 None
 0.67A 4z2dB-4magA:
undetectable
4z2dC-4magA:
undetectable		 4z2dB-4magA:
21.30
4z2dC-4magA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ojz PUTATIVE ALGINATE
LYASE

(Saccharophagus
degradans) 		PF05426
(Alginate_lyase)
PF07940
(Hepar_II_III) 		3 ARG A 135
GLY A 141
GLU A 131
 None
 0.63A 4z2dB-4ojzA:
1.5
4z2dC-4ojzA:
undetectable		 4z2dB-4ojzA:
20.74
4z2dC-4ojzA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ope NRPS/PKS

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		3 ARG A4252
GLY A4251
GLU A4250
 None
 0.63A 4z2dB-4opeA:
undetectable
4z2dC-4opeA:
undetectable		 4z2dB-4opeA:
20.80
4z2dC-4opeA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uss GLUTATHIONYL
HYDROQUINONE
REDUCTASE

(Populus
trichocarpa) 		PF13409
(GST_N_2)
PF13410
(GST_C_2) 		3 ARG A 110
GLY A 108
GLU A 114
 None
 0.61A 4z2dB-4ussA:
undetectable
4z2dC-4ussA:
undetectable		 4z2dB-4ussA:
19.80
4z2dC-4ussA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wnn HISTONE H2B.1

(Saccharomyces
cerevisiae) 		PF00125
(Histone) 		3 ARG B 119
GLY B 117
GLU B 116
 None
 0.63A 4z2dB-4wnnB:
undetectable
4z2dC-4wnnB:
undetectable		 4z2dB-4wnnB:
15.71
4z2dC-4wnnB:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x4j PUTATIVE OXYGENASE

(Amycolatopsis
orientalis) 		PF01494
(FAD_binding_3) 		3 ARG A  33
GLY A 117
GLU A  32
 FAD  A 503 (-3.4A)
None
FAD  A 503 (-2.5A)
 0.60A 4z2dB-4x4jA:
undetectable
4z2dC-4x4jA:
undetectable		 4z2dB-4x4jA:
24.73
4z2dC-4x4jA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z2e DNA GYRASE SUBUNIT B

(Streptococcus
pneumoniae) 		PF00986
(DNA_gyraseB_C)
PF01751
(Toprim) 		3 ARG C 456
GLY C 457
GLU C 475
 None
 0.20A 4z2dB-4z2eC:
undetectable
4z2dC-4z2eC:
35.1		 4z2dB-4z2eC:
19.26
4z2dC-4z2eC:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwl BETAINE-ALDEHYDE
DEHYDROGENASE

(Staphylococcus
aureus) 		PF00171
(Aldedh) 		3 ARG A 466
GLY A 472
GLU A 471
 None
 0.60A 4z2dB-4zwlA:
undetectable
4z2dC-4zwlA:
2.1		 4z2dB-4zwlA:
21.38
4z2dC-4zwlA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a22 VESICULAR STOMATITIS
VIRUS L POLYMERASE

(Vesicular
stomatitis
virus) 		PF00946
(Mononeg_RNA_pol)
PF14314
(Methyltrans_Mon)
PF14318
(Mononeg_mRNAcap) 		3 ARG A 623
GLY A 626
GLU A 636
 None
 0.65A 4z2dB-5a22A:
undetectable
4z2dC-5a22A:
2.4		 4z2dB-5a22A:
13.38
4z2dC-5a22A:
7.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aor DOSAGE COMPENSATION
REGULATOR

(Drosophila
melanogaster) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF04408
(HA2)
PF07717
(OB_NTP_bind) 		3 ARG A 124
GLY A 120
GLU A 121
 None
 0.64A 4z2dB-5aorA:
undetectable
4z2dC-5aorA:
3.1		 4z2dB-5aorA:
17.49
4z2dC-5aorA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cer BD0816

(Bdellovibrio
bacteriovorus) 		PF02113
(Peptidase_S13) 		3 ARG A 401
GLY A 364
GLU A 363
 None
 0.63A 4z2dB-5cerA:
undetectable
4z2dC-5cerA:
undetectable		 4z2dB-5cerA:
21.59
4z2dC-5cerA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dbk TRANSCRIPTIONAL
REGULATOR/TPR DOMAIN
PROTEIN

(Bacillus
thuringiensis) 		PF13424
(TPR_12) 		3 ARG A 220
GLY A 218
GLU A 217
 None
 0.49A 4z2dB-5dbkA:
1.4
4z2dC-5dbkA:
undetectable		 4z2dB-5dbkA:
22.10
4z2dC-5dbkA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5di0 NATTERIN-LIKE
PROTEIN

(Danio rerio) 		PF03318
(ETX_MTX2) 		3 ARG A 269
GLY A 268
GLU A 168
 None
PEG  A 411 (-3.8A)
None
 0.61A 4z2dB-5di0A:
undetectable
4z2dC-5di0A:
undetectable		 4z2dB-5di0A:
20.40
4z2dC-5di0A:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ei0 SERPIN A12

(Homo sapiens) 		PF00079
(Serpin) 		3 ARG A 363
GLY A 364
GLU A 217
 None
 0.47A 4z2dB-5ei0A:
undetectable
4z2dC-5ei0A:
undetectable		 4z2dB-5ei0A:
21.75
4z2dC-5ei0A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqx DESMOGLEIN-3

(Homo sapiens) 		PF00028
(Cadherin) 		3 ARG A  10
GLY A  12
GLU A  13
 None
 0.58A 4z2dB-5eqxA:
undetectable
4z2dC-5eqxA:
undetectable		 4z2dB-5eqxA:
22.84
4z2dC-5eqxA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h6s AMIDASE

(Microbacterium
sp. HM58-2) 		PF01425
(Amidase) 		3 ARG A  16
GLY A  20
GLU A  19
 None
 0.58A 4z2dB-5h6sA:
1.4
4z2dC-5h6sA:
undetectable		 4z2dB-5h6sA:
23.18
4z2dC-5h6sA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hcc COMPLEMENT C5

(Homo sapiens) 		PF01835
(A2M_N)
PF07703
(A2M_N_2) 		3 ARG B  32
GLY B  34
GLU B  37
 None
 0.58A 4z2dB-5hccB:
undetectable
4z2dC-5hccB:
undetectable		 4z2dB-5hccB:
21.44
4z2dC-5hccB:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i4e MYOSIN-14,ALPHA-ACTI
NIN A

(Dictyostelium
discoideum;
Homo sapiens) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		3 ARG A 225
GLY A 232
GLU A 235
 None
 0.64A 4z2dB-5i4eA:
undetectable
4z2dC-5i4eA:
undetectable		 4z2dB-5i4eA:
20.06
4z2dC-5i4eA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iva LPS-ASSEMBLY
LIPOPROTEIN LPTE

(Pseudomonas
aeruginosa) 		PF04390
(LptE) 		3 ARG B  75
GLY B  76
GLU B 112
 None
 0.62A 4z2dB-5ivaB:
undetectable
4z2dC-5ivaB:
undetectable		 4z2dB-5ivaB:
18.39
4z2dC-5ivaB:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1b WD REPEAT-CONTAINING
PROTEIN 48

(Homo sapiens) 		PF00400
(WD40)
PF11816
(DUF3337) 		3 ARG B 523
GLY B 522
GLU B 519
 None
 0.67A 4z2dB-5k1bB:
undetectable
4z2dC-5k1bB:
undetectable		 4z2dB-5k1bB:
21.13
4z2dC-5k1bB:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kij ENDOPLASMIC
RETICULUM
MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E

(Homo sapiens) 		PF01532
(Glyco_hydro_47) 		3 ARG A 495
GLY A 493
GLU A 492
 None
 0.57A 4z2dB-5kijA:
undetectable
4z2dC-5kijA:
undetectable		 4z2dB-5kijA:
21.42
4z2dC-5kijA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kk8 NUCLEOSIDE
DIPHOSPHATE KINASE

(Schistosoma
mansoni) 		PF00334
(NDK) 		3 ARG A  78
GLY A  77
GLU A   2
 None
 0.61A 4z2dB-5kk8A:
undetectable
4z2dC-5kk8A:
undetectable		 4z2dB-5kk8A:
14.37
4z2dC-5kk8A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE GAMMA
SUBUNIT

(Aromatoleum
aromaticum) 		PF01968
(Hydantoinase_A)
PF05378
(Hydant_A_N) 		3 ARG B 626
GLY B 563
GLU B 565
 None
 0.59A 4z2dB-5l9wB:
undetectable
4z2dC-5l9wB:
4.5		 4z2dB-5l9wB:
21.51
4z2dC-5l9wB:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA

(Methanotorris
formicicus) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		3 ARG A 105
GLY A 224
GLU A 280
 K  A 605 ( 4.0A)
None
None
 0.62A 4z2dB-5n28A:
undetectable
4z2dC-5n28A:
undetectable		 4z2dB-5n28A:
21.38
4z2dC-5n28A:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5njj PROTEIN NUMB HOMOLOG

(Homo sapiens) 		no annotation 3 ARG A  33
GLY A  31
GLU A  30
 None
 0.63A 4z2dB-5njjA:
undetectable
4z2dC-5njjA:
undetectable		 4z2dB-5njjA:
10.85
4z2dC-5njjA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN

(Burkholderia
ambifaria) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 ARG A  33
GLY A  34
GLU A  36
 None
 0.58A 4z2dB-5tnxA:
undetectable
4z2dC-5tnxA:
2.3		 4z2dB-5tnxA:
23.18
4z2dC-5tnxA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u25 DIHYDROLIPOAMIDE
DEHYDROGENASE (E3
COMPONENT OF
PYRUVATE AND
2-OXOGLUTARATE
DEHYDROGENASE
COMPLEXES)

(Neisseria
gonorrhoeae) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 ARG A 148
GLY A 226
GLU A 147
 FAD  A 601 (-3.6A)
None
FAD  A 601 (-2.8A)
 0.59A 4z2dB-5u25A:
undetectable
4z2dC-5u25A:
undetectable		 4z2dB-5u25A:
22.14
4z2dC-5u25A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uhu MYCINAMICIN IV
HYDROXYLASE/EPOXIDAS
E

(Micromonospora
griseorubida) 		PF00067
(p450) 		3 ARG A 302
GLY A 304
GLU A 305
 None
 0.65A 4z2dB-5uhuA:
undetectable
4z2dC-5uhuA:
undetectable		 4z2dB-5uhuA:
22.14
4z2dC-5uhuA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vrf CADMIUM AND ZINC
EFFLUX PUMP FIEF

(Shewanella
oneidensis) 		no annotation 3 ARG B 106
GLY B 104
GLU B 105
 None
 0.67A 4z2dB-5vrfB:
1.3
4z2dC-5vrfB:
undetectable		 4z2dB-5vrfB:
9.22
4z2dC-5vrfB:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wpw 11S GLOBULIN ISOFORM
1

(Cocos nucifera) 		no annotation 3 ARG A 359
GLY A 396
GLU A 398
 None
 0.54A 4z2dB-5wpwA:
undetectable
4z2dC-5wpwA:
undetectable		 4z2dB-5wpwA:
23.54
4z2dC-5wpwA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x3t ANTITOXIN VAPB26
RIBONUCLEASE VAPC26

(Mycobacterium
tuberculosis) 		PF01402
(RHH_1)
PF01850
(PIN) 		3 ARG A  47
GLY A  48
GLU B  62
 None
 0.54A 4z2dB-5x3tA:
undetectable
4z2dC-5x3tA:
undetectable		 4z2dB-5x3tA:
10.00
4z2dC-5x3tA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbp 3NT OXYGENASE BETA
SUBUNIT

(Diaphorobacter
sp. DS2) 		PF00866
(Ring_hydroxyl_B) 		3 ARG C 147
GLY C 148
GLU C 150
 None
 0.51A 4z2dB-5xbpC:
undetectable
4z2dC-5xbpC:
undetectable		 4z2dB-5xbpC:
16.26
4z2dC-5xbpC:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xea ENVELOPE
GLYCOPROTEIN

(Thogoto
thogotovirus) 		PF03273
(Baculo_gp64) 		3 ARG A 317
GLY A 315
GLU A 314
 None
 0.55A 4z2dB-5xeaA:
undetectable
4z2dC-5xeaA:
undetectable		 4z2dB-5xeaA:
22.01
4z2dC-5xeaA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z72 CCPC

(Bacillus
velezensis) 		no annotation 3 ARG A 155
GLY A 154
GLU A 268
 None
 0.44A 4z2dB-5z72A:
undetectable
4z2dC-5z72A:
undetectable		 4z2dB-5z72A:
11.31
4z2dC-5z72A:
16.80