SIMILAR PATTERNS OF AMINO ACIDS FOR 4YVG_A_SAMA301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aor ALDEHYDE FERREDOXIN
OXIDOREDUCTASE

(Pyrococcus
furiosus) 		PF01314
(AFOR_C)
PF02730
(AFOR_N) 		5 LEU A  66
GLY A  75
GLU A 101
GLY A  99
GLY A  74
 None
 1.10A 4yvgA-1aorA:
undetectable		 4yvgA-1aorA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo sapiens) 		PF00080
(Sod_Cu) 		5 GLY A 203
GLY A 222
ILE A 119
LEU A 129
GLY A 128
 None
 0.81A 4yvgA-1do5A:
undetectable		 4yvgA-1do5A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dub 2-ENOYL-COA
HYDRATASE

(Rattus
norvegicus) 		PF00378
(ECH_1) 		5 GLY A 175
ILE A  66
LEU A 145
GLY A 142
GLY A 141
 None
None
None
None
CAA  A 300 (-3.6A)
 1.06A 4yvgA-1dubA:
undetectable		 4yvgA-1dubA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gcy GLUCAN
1,4-ALPHA-MALTOTETRA
HYDROLASE

(Pseudomonas
stutzeri) 		PF00128
(Alpha-amylase)
PF09081
(DUF1921) 		5 SER A  52
ILE A  46
LEU A 102
GLY A 103
GLY A 106
 None
 1.10A 4yvgA-1gcyA:
undetectable		 4yvgA-1gcyA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1geu GLUTATHIONE
REDUCTASE

(Escherichia
coli) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 GLY A  12
GLY A  16
ILE A  95
GLY A  40
GLY A  39
 FAD  A 451 ( 4.9A)
None
None
FAD  A 451 (-3.2A)
None
 1.03A 4yvgA-1geuA:
undetectable		 4yvgA-1geuA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gqr ACETYLCHOLINESTERASE

(Tetronarce
californica) 		PF00135
(COesterase) 		5 LEU A 156
PRO A 165
GLY A 154
GLY A 169
ILE A 263
 None
 0.90A 4yvgA-1gqrA:
undetectable		 4yvgA-1gqrA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gxk CHROMOSOME
SEGREGATION SMC
PROTEIN

(Thermotoga
maritima) 		PF06470
(SMC_hinge) 		5 GLY A 615
ILE A 576
LEU A 609
GLY A 610
GLY A 611
 None
 0.93A 4yvgA-1gxkA:
undetectable		 4yvgA-1gxkA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2

(Cricetulus
griseus) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 SER A 276
GLY A 326
GLY A 340
SER A 275
GLY A 324
 MOA  A1332 (-2.6A)
MOA  A1332 ( 3.5A)
None
None
None
 0.99A 4yvgA-1jr1A:
undetectable		 4yvgA-1jr1A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ns5 HYPOTHETICAL PROTEIN
YBEA

(Escherichia
coli) 		PF02590
(SPOUT_MTase) 		5 LEU A  72
GLY A 103
GLY A 107
SER A 121
LEU A 127
 None
 0.74A 4yvgA-1ns5A:
7.3		 4yvgA-1ns5A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxz HYPOTHETICAL PROTEIN
HI0303

(Haemophilus
influenzae) 		PF04452
(Methyltrans_RNA) 		5 LEU A 167
GLU A 162
ILE A 185
GLY A 165
PRO A 186
 None
 1.07A 4yvgA-1nxzA:
6.0		 4yvgA-1nxzA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oj4 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE

(Escherichia
coli) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 GLY A 105
GLY A 107
SER A 178
ILE A 179
GLY A 103
 ANP  A1285 (-2.6A)
ANP  A1285 (-3.2A)
None
None
ANP  A1285 (-3.0A)
 1.02A 4yvgA-1oj4A:
undetectable		 4yvgA-1oj4A:
22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1oy5 TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Aquifex
aeolicus) 		PF01746
(tRNA_m1G_MT) 		6 GLY A 115
GLU A 118
GLY A 119
LEU A 139
GLY A 141
GLY A 142
 None
 0.63A 4yvgA-1oy5A:
18.7		 4yvgA-1oy5A:
36.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1p9p TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Escherichia
coli) 		PF01746
(tRNA_m1G_MT) 		12 LEU A  87
SER A  88
PRO A  89
GLY A 113
GLU A 116
GLY A 117
SER A 132
ILE A 133
LEU A 138
GLY A 140
GLY A 141
PRO A 144
 SAH  A 300 (-4.4A)
None
SAH  A 300 (-3.8A)
SAH  A 300 (-3.2A)
None
SAH  A 300 (-3.6A)
SAH  A 300 (-3.6A)
SAH  A 300 (-4.4A)
SAH  A 300 (-4.1A)
SAH  A 300 (-3.1A)
SAH  A 300 (-3.5A)
SAH  A 300 (-4.5A)
 0.31A 4yvgA-1p9pA:
31.0		 4yvgA-1p9pA:
78.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rbl RIBULOSE 1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E (LARGE CHAIN)

(Synechococcus
elongatus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 GLY A 373
GLU A 158
GLY A 154
SER A 321
LEU A 326
 None
 0.82A 4yvgA-1rblA:
undetectable		 4yvgA-1rblA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svd RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE/OXYGENAS
E LARGE SUBUNIT

(Halothiobacillus
neapolitanus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 GLY A 366
GLU A 151
GLY A 147
SER A 314
LEU A 319
 None
 0.77A 4yvgA-1svdA:
undetectable		 4yvgA-1svdA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wuu GALACTOKINASE

(Homo sapiens) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		5 LEU A 139
SER A 140
LEU A 135
GLY A 136
GLY A 137
 None
ANP  A 395 ( 3.1A)
ANP  A 395 (-4.3A)
ANP  A 395 (-3.4A)
ANP  A 395 (-4.6A)
 0.89A 4yvgA-1wuuA:
undetectable		 4yvgA-1wuuA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ch6 N-ACETYL-D-GLUCOSAMI
NE KINASE

(Homo sapiens) 		PF01869
(BcrAD_BadFG) 		5 GLY A 239
GLU A 153
GLY A 154
ILE A 266
GLY A 243
 None
 1.02A 4yvgA-2ch6A:
undetectable		 4yvgA-2ch6A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1q LUCIFERIN
4-MONOOXYGENASE

(Luciola
cruciata) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 PRO A 244
GLY A 530
GLY A 318
ILE A 110
GLY A 527
 None
None
AMP  A1001 (-3.5A)
None
None
 1.00A 4yvgA-2d1qA:
undetectable		 4yvgA-2d1qA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3t FATTY OXIDATION
COMPLEX ALPHA
SUBUNIT

(Pseudomonas
fragi) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 LEU A 115
GLY A  68
ILE A 136
GLY A 117
GLY A 116
 None
 0.91A 4yvgA-2d3tA:
undetectable		 4yvgA-2d3tA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpn GLYCEROL KINASE

(Thermus
thermophilus) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 SER A 451
PRO A 452
GLY A 448
GLY A 446
GLY A 444
 None
 0.92A 4yvgA-2dpnA:
undetectable		 4yvgA-2dpnA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fnc MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF13416
(SBP_bac_8) 		5 GLY A 169
GLU A 189
GLY A 190
ILE A 371
GLY A 185
 None
 1.09A 4yvgA-2fncA:
undetectable		 4yvgA-2fncA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g8s GLUCOSE/SORBOSONE
DEHYDROGENASES

(Escherichia
coli) 		PF07995
(GSDH) 		5 GLY A 145
GLY A 129
ILE A 188
LEU A 159
GLY A 161
 None
 1.00A 4yvgA-2g8sA:
undetectable		 4yvgA-2g8sA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gzs IROE PROTEIN

(Escherichia
coli) 		PF00756
(Esterase) 		5 PRO A 136
GLY A 216
SER A 157
GLY A 192
GLY A 191
 None
DFP  A1189 (-3.6A)
None
None
None
 0.67A 4yvgA-2gzsA:
2.2		 4yvgA-2gzsA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iht CARBOXYETHYLARGININE
SYNTHASE

(Streptomyces
clavuligerus) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 SER A 470
GLY A 439
GLY A 465
ILE A 476
GLY A 441
 None
None
TPP  A 600 (-3.5A)
None
None
 0.96A 4yvgA-2ihtA:
undetectable		 4yvgA-2ihtA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT

(Thermus
thermophilus) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		5 LEU A 661
GLY A 689
GLY A 659
GLY A 660
PRO A 445
 None
 1.08A 4yvgA-2ipcA:
undetectable		 4yvgA-2ipcA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0w LYSINE-SENSITIVE
ASPARTOKINASE 3

(Escherichia
coli) 		PF00696
(AA_kinase)
PF01842
(ACT) 		5 PRO A 261
GLY A 197
GLY A 357
GLY A 199
GLY A 200
 None
None
None
ASP  A 502 (-3.1A)
ASP  A 502 (-4.2A)
 0.72A 4yvgA-2j0wA:
undetectable		 4yvgA-2j0wA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lbw H/ACA
RIBONUCLEOPROTEIN
COMPLEX SUBUNIT 2

(Saccharomyces
cerevisiae) 		PF01248
(Ribosomal_L7Ae) 		5 LEU A 110
GLY A 114
SER A 121
ILE A  81
GLY A 111
 None
 0.93A 4yvgA-2lbwA:
undetectable		 4yvgA-2lbwA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odl ADHESIN

(Haemophilus
influenzae) 		PF05860
(Haemagg_act) 		5 LEU A 343
GLY A 348
GLY A 383
SER A 315
GLY A 323
 None
 0.83A 4yvgA-2odlA:
undetectable		 4yvgA-2odlA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3e DIAMINOPIMELATE
DECARBOXYLASE

(Aquifex
aeolicus) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 GLY A 244
GLY A 206
LEU A 210
GLY A 246
PRO A 256
 None
 1.07A 4yvgA-2p3eA:
undetectable		 4yvgA-2p3eA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2paa PHOSPHOGLYCERATE
KINASE, TESTIS
SPECIFIC

(Mus musculus) 		PF00162
(PGK) 		5 LEU A 211
GLY A 337
ILE A 223
GLY A 213
GLY A 212
 None
ATP  A 500 (-3.1A)
None
ATP  A 500 (-2.8A)
None
 1.10A 4yvgA-2paaA:
undetectable		 4yvgA-2paaA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r66 GLYCOSYL
TRANSFERASE, GROUP 1

(Halothermothrix
orenii) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		5 GLY A 129
GLY A 150
LEU A  13
GLY A 131
GLY A 132
 None
 1.10A 4yvgA-2r66A:
undetectable		 4yvgA-2r66A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpj KELCH-LIKE PROTEIN
12

(Homo sapiens) 		PF01344
(Kelch_1) 		5 GLY A 420
GLY A 467
SER A 324
ILE A 334
GLY A 373
 None
 0.99A 4yvgA-2vpjA:
undetectable		 4yvgA-2vpjA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yhg CELLULOSE-BINDING
PROTEIN

(Saccharophagus
degradans) 		PF07632
(DUF1593) 		5 LEU A 745
GLY A 762
GLY A 765
GLY A 764
PRO A 742
 None
MG  A1939 (-3.9A)
MG  A1939 (-3.8A)
None
None
 1.02A 4yvgA-2yhgA:
undetectable		 4yvgA-2yhgA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a24 ALPHA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		5 GLY A 524
GLY A 631
LEU A 651
GLY A 655
GLY A 654
 None
 1.06A 4yvgA-3a24A:
undetectable		 4yvgA-3a24A:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ab1 FERREDOXIN--NADP
REDUCTASE

(Chlorobaculum
tepidum) 		PF07992
(Pyr_redox_2) 		5 GLY A  22
GLY A  26
ILE A  74
GLY A  51
GLY A  50
 FAD  A 361 ( 4.7A)
None
None
FAD  A 361 (-3.0A)
None
 1.02A 4yvgA-3ab1A:
undetectable		 4yvgA-3ab1A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b0h NITRITE REDUCTASE

(Nicotiana
tabacum) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		5 LEU A 369
SER A 428
GLY A 355
ILE A 371
GLY A 368
 None
 1.08A 4yvgA-3b0hA:
undetectable		 4yvgA-3b0hA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b89 16S RRNA METHYLASE

(Escherichia
coli) 		PF07091
(FmrO) 		5 GLU A 180
ILE A 233
LEU A 227
GLY A 226
GLY A 225
 None
 1.09A 4yvgA-3b89A:
undetectable		 4yvgA-3b89A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3btu GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80

(Saccharomyces
cerevisiae) 		PF01408
(GFO_IDH_MocA) 		5 GLY A 182
GLY A 282
ILE A 178
LEU A 292
GLY A 310
 None
 1.08A 4yvgA-3btuA:
undetectable		 4yvgA-3btuA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdj DEGV FAMILY PROTEIN

([Eubacterium]
eligens) 		PF02645
(DegV) 		5 LEU A 156
SER A 158
GLU A  49
GLY A 266
GLY A 267
 None
 1.08A 4yvgA-3fdjA:
undetectable		 4yvgA-3fdjA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ftb HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Clostridium
acetobutylicum) 		PF00155
(Aminotran_1_2) 		5 GLY A  86
ILE A  70
LEU A  83
GLY A  84
GLY A 225
 PO4  A 362 (-3.4A)
None
None
None
None
 0.90A 4yvgA-3ftbA:
undetectable		 4yvgA-3ftbA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO

(Thermus
thermophilus) 		PF01134
(GIDA) 		5 LEU A 399
PRO A 401
GLY A 420
GLY A 376
GLY A 377
 None
 1.00A 4yvgA-3g5sA:
undetectable		 4yvgA-3g5sA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 1

(Thermus
thermophilus) 		PF01512
(Complex1_51K)
PF10531
(SLBB)
PF10589
(NADH_4Fe-4S) 		5 GLY 1 324
GLY 1  67
ILE 1 329
GLY 1 326
GLY 1 293
 None
 1.08A 4yvgA-3i9v1:
undetectable		 4yvgA-3i9v1:
20.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ief TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Bartonella
henselae) 		PF01746
(tRNA_m1G_MT) 		8 SER A  86
PRO A  87
GLY A 111
SER A 130
ILE A 131
LEU A 136
GLY A 138
GLY A 139
 None
 0.59A 4yvgA-3iefA:
21.4		 4yvgA-3iefA:
43.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3it4 ARGININE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
ARGJ ALPHA CHAIN
ARGININE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
ARGJ BETA CHAIN

(Mycobacterium
tuberculosis;
Mycobacterium
tuberculosis) 		PF01960
(ArgJ)
PF01960
(ArgJ) 		5 GLY A  15
GLY A 157
LEU B 205
GLY A 186
GLY A 185
 None
 1.11A 4yvgA-3it4A:
undetectable		 4yvgA-3it4A:
23.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3knu TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Anaplasma
phagocytophilum) 		PF01746
(tRNA_m1G_MT) 		10 SER A  87
PRO A  88
GLY A 112
GLU A 115
GLY A 116
SER A 131
ILE A 132
LEU A 137
GLY A 139
GLY A 140
 None
 0.40A 4yvgA-3knuA:
21.8		 4yvgA-3knuA:
40.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ky7 TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Staphylococcus
aureus) 		PF01746
(tRNA_m1G_MT) 		6 GLY A 111
SER A 130
LEU A 136
GLY A 138
GLY A 139
PRO A 142
 None
OCS  A  86 ( 3.8A)
None
None
None
None
 0.67A 4yvgA-3ky7A:
19.7		 4yvgA-3ky7A:
44.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ky7 TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Staphylococcus
aureus) 		PF01746
(tRNA_m1G_MT) 		5 PRO A  87
GLY A 111
GLU A 114
GLY A 138
GLY A 139
 OCS  A  86 ( 2.5A)
None
None
None
None
 1.06A 4yvgA-3ky7A:
19.7		 4yvgA-3ky7A:
44.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ky7 TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Staphylococcus
aureus) 		PF01746
(tRNA_m1G_MT) 		6 PRO A  87
GLY A 111
SER A 130
LEU A 136
GLY A 138
GLY A 139
 OCS  A  86 ( 2.5A)
None
OCS  A  86 ( 3.8A)
None
None
None
 0.63A 4yvgA-3ky7A:
19.7		 4yvgA-3ky7A:
44.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qgv ALPHA AMYLASE

(Pyrococcus
woesei) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		5 GLY A  53
GLY A  61
SER A  22
GLY A  55
GLY A  56
 None
 1.10A 4yvgA-3qgvA:
undetectable		 4yvgA-3qgvA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qsg NAD-BINDING
PHOSPHOGLUCONATE
DEHYDROGENASE-LIKE
PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF03807
(F420_oxidored)
PF09130
(DUF1932) 		5 GLU A 156
LEU A 167
GLY A 164
GLY A 163
PRO A  97
 None
 0.85A 4yvgA-3qsgA:
undetectable		 4yvgA-3qsgA:
24.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3quv TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Mycobacteroides
abscessus) 		PF01746
(tRNA_m1G_MT) 		6 GLY A 109
GLY A 113
ILE A 133
LEU A 138
GLY A 140
GLY A 141
 EDO  A 244 ( 4.1A)
EDO  A 244 (-3.4A)
None
EDO  A 243 (-4.0A)
EDO  A 243 (-4.1A)
EDO  A 243 (-3.6A)
 0.49A 4yvgA-3quvA:
20.7		 4yvgA-3quvA:
40.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3quv TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Mycobacteroides
abscessus) 		PF01746
(tRNA_m1G_MT) 		6 PRO A  85
GLY A 109
GLY A 113
ILE A 133
LEU A 138
GLY A 141
 EDO  A 243 (-3.7A)
EDO  A 244 ( 4.1A)
EDO  A 244 (-3.4A)
None
EDO  A 243 (-4.0A)
EDO  A 243 (-3.6A)
 0.77A 4yvgA-3quvA:
20.7		 4yvgA-3quvA:
40.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3quv TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Mycobacteroides
abscessus) 		PF01746
(tRNA_m1G_MT) 		5 PRO A  85
GLY A 109
GLY A 113
SER A 132
ILE A 133
 EDO  A 243 (-3.7A)
EDO  A 244 ( 4.1A)
EDO  A 244 (-3.4A)
None
None
 1.01A 4yvgA-3quvA:
20.7		 4yvgA-3quvA:
40.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s2u UDP-N-ACETYLGLUCOSAM
INE--N-ACETYLMURAMYL
-(PENTAPEPTIDE)
PYROPHOSPHORYL-UNDEC
APRENOL
N-ACETYLGLUCOSAMINE
TRANSFERASE

(Pseudomonas
aeruginosa) 		PF03033
(Glyco_transf_28)
PF04101
(Glyco_tran_28_C) 		6 LEU A  99
GLY A  10
GLY A  37
ILE A 120
GLY A 101
GLY A 100
 None
 0.96A 4yvgA-3s2uA:
undetectable		 4yvgA-3s2uA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbh O-ACETYL SERINE
SULFHYDRYLASE

(Leishmania
donovani) 		PF00291
(PALP) 		5 GLY A  95
SER A  14
ILE A  15
LEU A  90
GLY A  91
 None
 0.85A 4yvgA-3tbhA:
undetectable		 4yvgA-3tbhA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4p INTEGRIN ALPHA-4

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		5 GLY A 274
GLY A 238
ILE A 355
LEU A 291
GLY A 293
 None
 0.83A 4yvgA-3v4pA:
undetectable		 4yvgA-3v4pA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zbq PHIKZ039

(Pseudomonas
virus phiKZ) 		no annotation 5 GLY A  16
GLU A  21
GLY A  20
GLY A  14
GLY A  13
 None
None
None
GDP  A 999 (-3.3A)
GDP  A 999 (-3.6A)
 0.86A 4yvgA-3zbqA:
undetectable		 4yvgA-3zbqA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayj BOGT -
METAL-INDEPENDENT
GLYCOSYLTRANSFERASE

(Bacteroides
ovatus) 		PF03414
(Glyco_transf_6) 		5 PRO A 204
LEU A 118
GLY A 160
GLY A 161
PRO A 110
 None
 0.98A 4yvgA-4ayjA:
undetectable		 4yvgA-4ayjA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bm1 MANGANESE PEROXIDASE
4

(Pleurotus
ostreatus) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		5 SER A  54
PRO A  55
GLY A  52
GLY A  67
GLY A  66
 None
None
CA  A 401 ( 4.9A)
CA  A 401 (-4.3A)
None
 1.10A 4yvgA-4bm1A:
undetectable		 4yvgA-4bm1A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crm TRANSLATION
INITIATION FACTOR
RLI1

(Saccharomyces
cerevisiae) 		PF00005
(ABC_tran)
PF00037
(Fer4)
PF04068
(RLI) 		5 LEU P 252
SER P 250
LEU P 227
GLY P 224
GLY P 225
 None
 1.10A 4yvgA-4crmP:
undetectable		 4yvgA-4crmP:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvc ALCOHOL
DEHYDROGENASE

(Pseudogluconobacter
saccharoketogenes) 		PF13360
(PQQ_2) 		5 SER A  79
PRO A  80
GLY A  77
GLY A  71
PRO A 447
 None
 1.01A 4yvgA-4cvcA:
undetectable		 4yvgA-4cvcA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dcm RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G

(Escherichia
coli) 		PF05175
(MTS) 		5 GLY A 240
GLY A 238
ILE A 232
LEU A 303
GLY A 243
 None
SAM  A 401 ( 3.7A)
None
None
None
 0.83A 4yvgA-4dcmA:
undetectable		 4yvgA-4dcmA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dcm RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G

(Escherichia
coli) 		PF05175
(MTS) 		5 SER A 261
GLY A 236
GLY A 238
SER A  73
ILE A  75
 None
SAM  A 401 (-3.5A)
SAM  A 401 ( 3.7A)
None
None
 1.07A 4yvgA-4dcmA:
undetectable		 4yvgA-4dcmA:
20.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4h3z TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Paraburkholderia
phymatum) 		PF01746
(tRNA_m1G_MT) 		8 SER A  92
PRO A  93
GLY A 117
GLU A 120
SER A 136
LEU A 142
GLY A 145
PRO A 148
 None
SAH  A 301 (-3.7A)
SAH  A 301 (-3.5A)
SAH  A 301 (-3.5A)
SAH  A 301 (-3.4A)
SAH  A 301 (-4.3A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.4A)
 0.61A 4yvgA-4h3zA:
28.3		 4yvgA-4h3zA:
51.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4h3z TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Paraburkholderia
phymatum) 		PF01746
(tRNA_m1G_MT) 		8 SER A  92
PRO A  93
GLY A 117
SER A 136
LEU A 142
GLY A 144
GLY A 145
PRO A 148
 None
SAH  A 301 (-3.7A)
SAH  A 301 (-3.5A)
SAH  A 301 (-3.4A)
SAH  A 301 (-4.3A)
SAH  A 301 (-3.1A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.4A)
 0.21A 4yvgA-4h3zA:
28.3		 4yvgA-4h3zA:
51.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h7u PYRANOSE
DEHYDROGENASE

(Leucoagaricus
meleagris) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 GLY A  24
GLY A  22
ILE A  72
GLY A  98
GLY A  99
 FED  A 801 (-3.3A)
FED  A 801 (-3.3A)
None
None
FED  A 801 (-3.1A)
 1.04A 4yvgA-4h7uA:
undetectable		 4yvgA-4h7uA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iss ALLOPHANATE
HYDROLASE

(Kluyveromyces
lactis) 		PF01425
(Amidase) 		5 LEU A 123
SER A 154
GLY A 132
GLY A 151
GLY A 129
 None
None
None
None
TAR  A 701 (-3.7A)
 1.11A 4yvgA-4issA:
undetectable		 4yvgA-4issA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhp X-LINKED RETINITIS
PIGMENTOSA GTPASE
REGULATOR

(Homo sapiens) 		PF00415
(RCC1) 		5 GLY C 198
GLY C 148
SER C 301
GLY C 252
GLY C 251
 None
 1.03A 4yvgA-4jhpC:
undetectable		 4yvgA-4jhpC:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kmh SUPPRESSOR OF FUSED
HOMOLOG

(Homo sapiens) 		PF05076
(SUFU)
PF12470
(SUFU_C) 		5 GLY A 263
GLY A 387
SER A 210
ILE A 219
GLY A 258
 None
 0.99A 4yvgA-4kmhA:
undetectable		 4yvgA-4kmhA:
26.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mif PYRANOSE 2-OXIDASE

(Phanerochaete
chrysosporium) 		PF05199
(GMC_oxred_C) 		5 PRO A 597
GLY A 587
GLU A 146
ILE A 602
GLY A 585
 FDA  A 801 (-4.1A)
None
None
None
FDA  A 801 (-3.4A)
 1.06A 4yvgA-4mifA:
undetectable		 4yvgA-4mifA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nen INTEGRIN ALPHA-X

(Homo sapiens) 		PF00092
(VWA)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		5 GLY A 440
GLY A 404
ILE A 522
LEU A 458
GLY A 460
 None
 0.94A 4yvgA-4nenA:
undetectable		 4yvgA-4nenA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nwz FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE

(Caldalkalibacillus
thermarum) 		PF07992
(Pyr_redox_2) 		5 GLY A  14
GLU A 324
GLY A 323
ILE A  65
GLY A  12
 FAD  A 601 (-4.2A)
None
None
None
FAD  A 601 (-3.3A)
 1.01A 4yvgA-4nwzA:
undetectable		 4yvgA-4nwzA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhm ARGINASE

(Trypanosoma
brucei) 		PF00491
(Arginase) 		5 PRO A 271
GLY A  32
GLU A  87
LEU A  41
GLY A 121
 None
 0.84A 4yvgA-4rhmA:
undetectable		 4yvgA-4rhmA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tz5 PUTATIVE SECRETED
PROTEIN

(Streptomyces
sp. SirexAA-E) 		no annotation 5 GLY A 209
GLY A 186
SER A 224
GLY A 228
GLY A 227
 None
 0.86A 4yvgA-4tz5A:
undetectable		 4yvgA-4tz5A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xii CHOLINESTERASE

(Homo sapiens) 		PF00135
(COesterase) 		5 LEU A 154
PRO A 163
GLY A 152
GLY A 167
ILE A 261
 None
 0.85A 4yvgA-4xiiA:
undetectable		 4yvgA-4xiiA:
19.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ypw TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Haemophilus
influenzae) 		PF01746
(tRNA_m1G_MT) 		12 LEU A  87
SER A  88
PRO A  89
GLY A 113
GLU A 116
GLY A 117
SER A 132
ILE A 133
LEU A 138
GLY A 140
GLY A 141
PRO A 144
 None
None
4FD  A 301 ( 3.6A)
4FD  A 301 (-4.7A)
None
4FD  A 301 (-3.6A)
4FD  A 301 (-3.2A)
4FD  A 301 (-4.1A)
4FD  A 301 (-3.9A)
4FD  A 301 (-3.6A)
4FD  A 301 (-3.9A)
4FD  A 301 (-4.5A)
 0.34A 4yvgA-4ypwA:
31.6		 4yvgA-4ypwA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE

(Geobacillus
stearothermophilus) 		PF00232
(Glyco_hydro_1) 		5 LEU A 181
GLY A 178
GLU A 139
GLY A 187
GLY A 182
 None
 1.00A 4yvgA-4zfmA:
undetectable		 4yvgA-4zfmA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5azb PROLIPOPROTEIN
DIACYLGLYCERYL
TRANSFERASE

(Escherichia
coli) 		PF01790
(LGT) 		5 GLY A  71
GLY A  75
LEU A 106
GLY A 105
GLY A 108
 PGT  A 309 ( 3.7A)
None
None
BOG  A 303 ( 4.1A)
PGT  A 309 (-3.6A)
 0.86A 4yvgA-5azbA:
undetectable		 4yvgA-5azbA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bov PUTATIVE EPOXIDE
HYDROLASE PROTEIN

(Klebsiella
pneumoniae) 		PF00561
(Abhydrolase_1) 		5 SER A 249
GLU A 268
GLY A 260
LEU A 255
GLY A 256
 None
 1.00A 4yvgA-5bovA:
undetectable		 4yvgA-5bovA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fai RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE
NEP1

(Homo sapiens) 		PF03587
(EMG1) 		5 SER A 177
GLY A 201
SER A 218
ILE A 219
LEU A 224
 CIT  A 302 ( 2.7A)
SAH  A 301 (-3.2A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.3A)
SAH  A 301 (-4.0A)
 0.64A 4yvgA-5faiA:
undetectable		 4yvgA-5faiA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fav CHOLINE
TRIMETHYLAMINE-LYASE

(Desulfovibrio
alaskensis) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		5 GLY A 773
ILE A 741
LEU A 843
GLY A 845
PRO A 738
 None
 1.04A 4yvgA-5favA:
undetectable		 4yvgA-5favA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffn ENZYME SUBTILASE
SUBTY FROM BACILLUS
SP. TY145

(Bacillus sp.
(in: Bacteria)) 		PF00082
(Peptidase_S8) 		5 GLY A 179
GLY A 169
ILE A 221
GLY A 182
GLY A 183
 None
None
None
NA  A 403 (-4.6A)
NA  A 403 (-3.9A)
 0.84A 4yvgA-5ffnA:
2.5		 4yvgA-5ffnA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5htp PROBABLE SUGAR
KINASE

(Synechococcus
elongatus) 		PF02782
(FGGY_C) 		5 GLY A 242
GLY A 281
ILE A 397
GLY A 376
GLY A 375
 ANP  A 501 (-3.3A)
ANP  A 501 (-3.4A)
None
ANP  A 501 (-3.6A)
ANP  A 501 (-3.6A)
 1.09A 4yvgA-5htpA:
undetectable		 4yvgA-5htpA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hz1 PROBABLE LRR
RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE
AT4G26540

(Arabidopsis
thaliana) 		PF13855
(LRR_8) 		5 LEU B 514
SER B 515
SER B 493
ILE B 494
LEU B 518
 None
 1.00A 4yvgA-5hz1B:
undetectable		 4yvgA-5hz1B:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1

(Homo sapiens) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		5 LEU A  57
GLU A  38
GLY A  39
GLY A  55
GLY A  56
 None
 1.05A 4yvgA-5iy9A:
undetectable		 4yvgA-5iy9A:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6b ALDEHYDE
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00171
(Aldedh) 		5 SER A 452
GLY A 447
GLY A 429
LEU A 454
GLY A 455
 None
 1.01A 4yvgA-5j6bA:
undetectable		 4yvgA-5j6bA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jd5 MGS-MILE3

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 LEU A 196
GLY A 199
ILE A 165
GLY A 171
GLY A 172
 None
OAS  A 169 ( 3.4A)
None
OAS  A 169 ( 3.8A)
OAS  A 169 ( 3.1A)
 1.08A 4yvgA-5jd5A:
undetectable		 4yvgA-5jd5A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jry NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans) 		PF00171
(Aldedh) 		5 SER A 452
GLY A 447
GLY A 429
LEU A 454
GLY A 455
 None
NDP  A 500 ( 4.7A)
None
GOL  A 502 (-3.9A)
None
 0.99A 4yvgA-5jryA:
undetectable		 4yvgA-5jryA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5khl HEMIN ABC
TRANSPORTER,
PERIPLASMIC
HEMIN-BINDING
PROTEIN HUTB

(Vibrio cholerae) 		PF01497
(Peripla_BP_2) 		5 LEU B 260
SER B 111
GLU B  87
ILE B 181
LEU B 256
 None
 0.73A 4yvgA-5khlB:
undetectable		 4yvgA-5khlB:
27.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m49 AMINOTRANSFERASE
CLASS-III

(Rhizobium
freirei) 		PF00202
(Aminotran_3) 		5 LEU A  54
GLY A 268
GLY A  50
GLY A 272
GLY A 271
 None
 0.94A 4yvgA-5m49A:
undetectable		 4yvgA-5m49A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mbg BETA SUBUNIT OF
PHOTOACTIVATED
ADENYLYL CYCLASE

(Beggiatoa sp.
PS) 		PF00211
(Guanylate_cyc) 		5 LEU A 248
GLU A 150
GLY A 251
ILE A 216
GLY A 295
 None
 1.10A 4yvgA-5mbgA:
undetectable		 4yvgA-5mbgA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrr LYTIC ENDOPEPTIDASE
PREPROENZYME

(Lysobacter sp.
XL1) 		no annotation 5 GLY A  20
GLY A 145
ILE A  87
GLY A   6
GLY A   5
 None
 1.05A 4yvgA-5mrrA:
undetectable		 4yvgA-5mrrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mul NEURAMINIDASE

(Bacteroides
thetaiotaomicron) 		PF15892
(BNR_4) 		5 GLU A  51
SER A  44
ILE A  93
LEU A  65
GLY A  66
 None
 0.94A 4yvgA-5mulA:
undetectable		 4yvgA-5mulA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ndl CRH-LIKE PROTEIN

(Aspergillus
fumigatus) 		no annotation 5 LEU A 225
GLY A 105
GLY A 103
GLY A 223
GLY A 224
 None
 0.78A 4yvgA-5ndlA:
undetectable		 4yvgA-5ndlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nmi CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL

(Bos taurus) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 SER A  45
GLY A  54
GLU A  60
GLY A  56
GLY A 169
 None
 1.11A 4yvgA-5nmiA:
undetectable		 4yvgA-5nmiA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odr HETERODISULFIDE
REDUCTASE, SUBUNIT A

(Methanothermococcus
thermolithotrophicus) 		PF07992
(Pyr_redox_2)
PF13187
(Fer4_9) 		5 GLY A 151
GLY A 155
ILE A 196
GLY A 180
GLY A 179
 FAD  A 701 (-4.5A)
None
None
FAD  A 701 (-3.2A)
None
 0.96A 4yvgA-5odrA:
undetectable		 4yvgA-5odrA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wgx FLAVIN-DEPENDENT
HALOGENASE

(Malbranchea
aurantiaca) 		PF04820
(Trp_halogenase) 		5 GLY A 181
GLU A  37
ILE A 445
GLY A 179
GLY A 178
 None
 1.01A 4yvgA-5wgxA:
undetectable		 4yvgA-5wgxA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wyr TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Pseudomonas
aeruginosa) 		no annotation 12 LEU A  92
SER A  93
PRO A  94
GLY A 118
GLU A 121
GLY A 122
SER A 137
ILE A 138
LEU A 143
GLY A 145
GLY A 146
PRO A 149
 SFG  A 400 (-4.6A)
None
SFG  A 400 (-3.7A)
SFG  A 400 (-3.4A)
SFG  A 400 (-4.1A)
SFG  A 400 (-3.6A)
SFG  A 400 (-3.3A)
SFG  A 400 (-4.4A)
SFG  A 400 (-4.2A)
SFG  A 400 (-3.2A)
SFG  A 400 (-3.7A)
SFG  A 400 (-4.4A)
 0.32A 4yvgA-5wyrA:
30.2		 4yvgA-5wyrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum) 		no annotation 5 LEU A 388
SER A 662
GLY A 660
ILE A 609
GLY A 618
 None
 1.04A 4yvgA-5z9sA:
undetectable		 4yvgA-5z9sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gct NEUTRAL AMINO ACID
TRANSPORTER B(0)

(Homo sapiens) 		no annotation 5 LEU A 439
GLY A 427
ILE A 453
GLY A 434
GLY A 435
 None
None
None
GLN  A 601 ( 4.8A)
GLN  A 601 (-3.4A)
 1.02A 4yvgA-6gctA:
undetectable		 4yvgA-6gctA:
undetectable