SIMILAR PATTERNS OF AMINO ACIDS FOR 4YV5_B_SVRB207

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3r HDLP (HISTONE
DEACETYLASE-LIKE
PROTEIN)

(Aquifex
aeolicus) 		PF00850
(Hist_deacetyl) 		4 LEU A   6
ASN A 125
PRO A 126
ARG A  33
 None
 1.28A 4yv5A-1c3rA:
0.0		 4yv5A-1c3rA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
PF03173
(CHB_HEX)
PF03174
(CHB_HEX_C) 		4 LEU A 205
ASN A 800
PRO A 838
ARG A 825
 None
 1.36A 4yv5A-1c7tA:
0.0		 4yv5A-1c7tA:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cc1 HYDROGENASE (LARGE
SUBUNIT)

(Desulfomicrobium
baculatum) 		PF00374
(NiFeSe_Hases) 		4 LEU L 449
ASN L 453
PRO L 323
ARG L 337
 None
 1.30A 4yv5A-1cc1L:
undetectable		 4yv5A-1cc1L:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eh6 O6-ALKYLGUANINE-DNA
ALKYLTRANSFERASE

(Homo sapiens) 		PF01035
(DNA_binding_1)
PF02870
(Methyltransf_1N) 		4 LYS A  32
ASN A 137
PRO A 140
ARG A   9
 None
 1.34A 4yv5A-1eh6A:
undetectable		 4yv5A-1eh6A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gqj ALPHA-D-GLUCURONIDAS
E

(Cellvibrio
japonicus) 		PF03648
(Glyco_hydro_67N)
PF07477
(Glyco_hydro_67C)
PF07488
(Glyco_hydro_67M) 		4 PHE A 221
LEU A 182
ASN A 184
PRO A 183
 None
 1.42A 4yv5A-1gqjA:
0.0		 4yv5A-1gqjA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gux RETINOBLASTOMA
PROTEIN

(Homo sapiens) 		PF01858
(RB_A) 		4 PHE A 473
LYS A 472
ASN A 410
PRO A 411
 None
 1.27A 4yv5A-1guxA:
0.0		 4yv5A-1guxA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h5y HISF

(Pyrobaculum
aerophilum) 		PF00977
(His_biosynth) 		4 PHE A  65
LEU A  11
PRO A  35
ARG A  62
 None
 1.37A 4yv5A-1h5yA:
undetectable		 4yv5A-1h5yA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE

(Sus scrofa) 		PF01180
(DHO_dh)
PF07992
(Pyr_redox_2)
PF14691
(Fer4_20)
PF14697
(Fer4_21) 		4 LEU A 834
ASN A 544
PRO A 545
ARG A 771
 None
 1.34A 4yv5A-1h7wA:
0.0		 4yv5A-1h7wA:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jed SULFATE
ADENYLYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 PHE A 255
LEU A 258
PRO A 223
ARG A 186
 None
None
None
ACY  A 555 (-3.5A)
 1.24A 4yv5A-1jedA:
undetectable		 4yv5A-1jedA:
12.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mc2 ACUTOHAEMONLYSIN

(Deinagkistrodon
acutus) 		PF00068
(Phospholip_A2_1) 		4 LYS A1007
ASN A1016
PRO A1017
ARG A1072
 None
None
IPA  A1136 (-4.4A)
None
 0.63A 4yv5A-1mc2A:
23.9		 4yv5A-1mc2A:
77.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p2x RAS
GTPASE-ACTIVATING-LI
KE PROTEIN

(Schizosaccharomyces
pombe) 		PF00307
(CH) 		4 LEU A 133
ASN A 132
PRO A 134
ARG A 175
 None
None
BR  A 194 ( 4.9A)
BR  A 201 (-3.6A)
 1.21A 4yv5A-1p2xA:
undetectable		 4yv5A-1p2xA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s58 B19 PARVOVIRUS
CAPSID

(Primate
erythroparvovirus
1) 		PF00740
(Parvo_coat) 		4 LEU A 433
ASN A 432
PRO A 431
ARG A 329
 None
 1.45A 4yv5A-1s58A:
undetectable		 4yv5A-1s58A:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8w AMP NUCLEOSIDASE

(Escherichia
coli) 		PF01048
(PNP_UDP_1)
PF10423
(AMNp_N) 		4 PHE A 416
LEU A 292
PRO A 297
ARG A 415
 None
 1.32A 4yv5A-1t8wA:
undetectable		 4yv5A-1t8wA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2v ACTIN-RELATED
PROTEIN 2
ARP2/3 COMPLEX 16KDA
SUBUNIT

(Bos taurus) 		PF00022
(Actin)
PF04699
(P16-Arc) 		4 PHE G  11
LYS G   9
ASN B 226
ARG B 328
 None
 1.35A 4yv5A-1u2vG:
undetectable		 4yv5A-1u2vG:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v7v CHITOBIOSE
PHOSPHORYLASE

(Vibrio
proteolyticus) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 LEU A 669
ASN A 670
PRO A 671
ARG A 333
 None
 1.26A 4yv5A-1v7vA:
undetectable		 4yv5A-1v7vA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve3 HYPOTHETICAL PROTEIN
PH0226

(Pyrococcus
horikoshii) 		PF13649
(Methyltransf_25) 		4 LYS A 133
LEU A 132
ASN A 225
PRO A 226
 None
 1.40A 4yv5A-1ve3A:
undetectable		 4yv5A-1ve3A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vl4 PMBA-RELATED PROTEIN

(Thermotoga
maritima) 		PF01523
(PmbA_TldD) 		4 PHE A   3
LYS A   7
LEU A  10
PRO A  72
 None
 1.40A 4yv5A-1vl4A:
undetectable		 4yv5A-1vl4A:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y6l UBIQUITIN-CONJUGATIN
G ENZYME E2E2

(Homo sapiens) 		PF00179
(UQ_con) 		4 LYS A 101
LEU A 104
PRO A  18
ARG A   5
 None
 1.44A 4yv5A-1y6lA:
undetectable		 4yv5A-1y6lA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yem CONSERVED
HYPOTHETICAL PROTEIN
PFU-838710-001

(Pyrococcus
furiosus) 		PF01928
(CYTH) 		4 PHE A  14
LEU A 107
ASN A  22
PRO A  23
 None
 1.09A 4yv5A-1yemA:
undetectable		 4yv5A-1yemA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b61 HOMOSERINE
O-ACETYLTRANSFERASE

(Haemophilus
influenzae) 		PF00561
(Abhydrolase_1) 		4 LYS A  21
LEU A  16
ASN A 114
PRO A 113
 None
 1.43A 4yv5A-2b61A:
undetectable		 4yv5A-2b61A:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4b BARNASE MCOEETI
FUSION

(Bacillus
amyloliquefaciens;
Ecballium
elaterium;
Momordica
cochinchinensis) 		PF00299
(Squash)
PF00545
(Ribonuclease) 		4 LEU A  20
ASN A  23
PRO A  21
ARG A 110
 None
 1.45A 4yv5A-2c4bA:
undetectable		 4yv5A-2c4bA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5u VIRION PROTEIN UL25

(Human
alphaherpesvirus
1) 		PF01499
(Herpes_UL25) 		4 PHE A 464
LEU A 153
ASN A 152
PRO A 154
 None
 1.40A 4yv5A-2f5uA:
0.6		 4yv5A-2f5uA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i1j MOESIN

(Spodoptera
frugiperda) 		PF00373
(FERM_M)
PF00769
(ERM)
PF09379
(FERM_N)
PF09380
(FERM_C) 		4 PHE A  18
LEU A  76
ASN A  74
PRO A  75
 None
URE  A 577 (-4.2A)
URE  A 577 (-3.4A)
None
 1.10A 4yv5A-2i1jA:
undetectable		 4yv5A-2i1jA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT

(Thermus
thermophilus) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		4 PHE A 612
LEU A 592
ASN A 588
PRO A 589
 None
 1.41A 4yv5A-2ipcA:
undetectable		 4yv5A-2ipcA:
7.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mbr URIDINE
DIPHOSPHO-N-ACETYLEN
OLPYRUVYLGLUCOSAMINE
REDUCTASE

(Escherichia
coli) 		PF01565
(FAD_binding_4)
PF02873
(MurB_C) 		4 LYS A 217
LEU A 218
ASN A 226
PRO A 219
 EPU  A 402 (-3.6A)
EPU  A 402 ( 4.6A)
FAD  A 401 (-3.5A)
None
 1.40A 4yv5A-2mbrA:
undetectable		 4yv5A-2mbrA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mbr URIDINE
DIPHOSPHO-N-ACETYLEN
OLPYRUVYLGLUCOSAMINE
REDUCTASE

(Escherichia
coli) 		PF01565
(FAD_binding_4)
PF02873
(MurB_C) 		4 PHE A 318
LEU A 322
ASN A 233
PRO A 234
 None
None
EPU  A 402 (-2.9A)
None
 1.31A 4yv5A-2mbrA:
undetectable		 4yv5A-2mbrA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qxy RESPONSE REGULATOR

(Thermotoga
maritima) 		PF00072
(Response_reg) 		4 PHE A  17
LYS A  21
LEU A  24
ARG A  14
 None
 1.07A 4yv5A-2qxyA:
undetectable		 4yv5A-2qxyA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xrc HUMAN COMPLEMENT
FACTOR I

(Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00089
(Trypsin)
PF00530
(SRCR) 		4 LYS A 301
LEU A 304
PRO A  50
ARG A 169
 None
 1.40A 4yv5A-2xrcA:
undetectable		 4yv5A-2xrcA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xu0 ERYTHROCYTE MEMBRANE
PROTEIN 1

(Plasmodium
falciparum) 		PF05424
(Duffy_binding)
PF15447
(NTS) 		4 LEU A 210
ASN A 212
PRO A 211
ARG A 253
 None
None
GOL  A1491 (-4.8A)
None
 0.92A 4yv5A-2xu0A:
undetectable		 4yv5A-2xu0A:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2

(Saccharomyces
cerevisiae) 		PF04072
(LCM)
PF13418
(Kelch_4) 		4 PHE A 265
LEU A 256
ASN A 287
PRO A 258
 None
 1.37A 4yv5A-2zwaA:
undetectable		 4yv5A-2zwaA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aii GLUTAMYL-TRNA
SYNTHETASE

(Methanothermobacter
thermautotrophicus) 		PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C) 		4 PHE A 405
LEU A 448
PRO A 449
ARG A 438
 None
 1.30A 4yv5A-3aiiA:
undetectable		 4yv5A-3aiiA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayx MEMBRANE-BOUND
HYDROGENASE LARGE
SUBUNIT
MEMBRANE-BOUND
HYDROGENASE SMALL
SUBUNIT

(Hydrogenovibrio
marinus) 		PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		4 PHE A 174
ASN A 133
PRO A 134
ARG B  12
 None
 1.39A 4yv5A-3ayxA:
1.5		 4yv5A-3ayxA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b97 ALPHA-ENOLASE

(Homo sapiens) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 PHE A 260
LEU A 162
ASN A 215
ARG A 252
 None
 1.18A 4yv5A-3b97A:
undetectable		 4yv5A-3b97A:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bzh UBIQUITIN-CONJUGATIN
G ENZYME E2 E1

(Homo sapiens) 		PF00179
(UQ_con) 		4 LYS A 147
LEU A 150
PRO A  64
ARG A  51
 None
 1.44A 4yv5A-3bzhA:
undetectable		 4yv5A-3bzhA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ck2 CONSERVED
UNCHARACTERIZED
PROTEIN (PREDICTED
PHOSPHOESTERASE
COG0622)

(Streptococcus
pneumoniae) 		PF12850
(Metallophos_2) 		4 PHE A  34
LEU A 125
ASN A 126
PRO A 127
 None
 1.40A 4yv5A-3ck2A:
undetectable		 4yv5A-3ck2A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cqc NUCLEAR PORE COMPLEX
PROTEIN NUP133

(Homo sapiens) 		no annotation 4 PHE B 964
LYS B 968
LEU B 971
ASN B 958
 None
 1.35A 4yv5A-3cqcB:
undetectable		 4yv5A-3cqcB:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ejg NON-STRUCTURAL
PROTEIN 3

(Human
coronavirus
229E) 		PF01661
(Macro) 		4 PHE A 126
LEU A  45
PRO A 119
ARG A  93
 None
 1.39A 4yv5A-3ejgA:
undetectable		 4yv5A-3ejgA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fbg PUTATIVE ARGINATE
LYASE

(Staphylococcus
haemolyticus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A 322
ASN A  43
PRO A  44
ARG A 182
 None
 1.22A 4yv5A-3fbgA:
undetectable		 4yv5A-3fbgA:
15.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g8g PHOSPHOLIPASE A2,
AMMODYTOXIN A

(Vipera
ammodytes) 		PF00068
(Phospholip_A2_1) 		4 LEU A  10
ASN A  16
PRO A  17
ARG A  63
 None
 0.64A 4yv5A-3g8gA:
20.9		 4yv5A-3g8gA:
60.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdc THIOREDOXIN FAMILY
PROTEIN

(Geobacter
metallireducens) 		PF00578
(AhpC-TSA) 		4 PHE A 104
LEU A 118
ASN A  51
PRO A  45
 None
 1.45A 4yv5A-3hdcA:
undetectable		 4yv5A-3hdcA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdo HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Geobacter
metallireducens) 		PF00155
(Aminotran_1_2) 		4 PHE A 131
LEU A 153
ASN A 157
ARG A 129
 None
 1.38A 4yv5A-3hdoA:
undetectable		 4yv5A-3hdoA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hv0 TRYPTOPHANYL-TRNA
SYNTHETASE

(Cryptosporidium
parvum) 		PF00579
(tRNA-synt_1b) 		4 PHE A 353
LEU A 364
PRO A 404
ARG A 582
 None
 1.27A 4yv5A-3hv0A:
undetectable		 4yv5A-3hv0A:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iup PUTATIVE
NADPH:QUINONE
OXIDOREDUCTASE

(Cupriavidus
pinatubonensis) 		no annotation 4 LEU A  48
ASN A  44
PRO A  45
ARG A 203
 None
NDP  A 401 ( 4.8A)
NDP  A 401 (-4.3A)
NDP  A 401 (-3.4A)
 1.38A 4yv5A-3iupA:
undetectable		 4yv5A-3iupA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3js8 CHOLESTEROL OXIDASE

(Chromobacterium
sp. DS-1) 		PF01565
(FAD_binding_4)
PF09129
(Chol_subst-bind) 		4 LYS A 518
LEU A 521
PRO A 197
ARG A 505
 None
 1.21A 4yv5A-3js8A:
undetectable		 4yv5A-3js8A:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k96 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]

(Coxiella
burnetii) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		4 LEU A  54
ASN A  56
PRO A  55
ARG A 259
 None
 1.45A 4yv5A-3k96A:
undetectable		 4yv5A-3k96A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ka7 OXIDOREDUCTASE

(Methanosarcina
mazei) 		PF01593
(Amino_oxidase) 		4 LEU A  57
ASN A  59
PRO A  58
ARG A  38
 None
None
FAD  A 500 (-4.1A)
FAD  A 500 (-3.7A)
 1.29A 4yv5A-3ka7A:
undetectable		 4yv5A-3ka7A:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l9c 3-DEHYDROQUINATE
DEHYDRATASE

(Streptococcus
mutans) 		PF01487
(DHquinase_I) 		4 LEU A 127
ASN A 126
PRO A 124
ARG A  62
 None
 1.45A 4yv5A-3l9cA:
undetectable		 4yv5A-3l9cA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lyr TRANSCRIPTION FACTOR
COE1

(Homo sapiens) 		PF16422
(COE1_DBD) 		4 PHE A 211
LEU A  62
PRO A  59
ARG A 209
 None
 1.38A 4yv5A-3lyrA:
undetectable		 4yv5A-3lyrA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mln TRANSCRIPTION FACTOR
COE1

(Mus musculus) 		PF16422
(COE1_DBD) 		4 PHE A 211
LEU A  62
PRO A  59
ARG A 209
 None
 1.46A 4yv5A-3mlnA:
undetectable		 4yv5A-3mlnA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3muo PROLYL ENDOPEPTIDASE

(Aeromonas
caviae) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		4 PHE A 114
LEU A 128
PRO A 117
ARG A 104
 None
 1.45A 4yv5A-3muoA:
undetectable		 4yv5A-3muoA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfr MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Actinobacillus
succinogenes) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 384
ASN A 382
PRO A 383
ARG A  39
 None
 1.28A 4yv5A-3pfrA:
undetectable		 4yv5A-3pfrA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6f HYPOTHETICAL
ACETYLTRANSFERASE

(Deinococcus
radiodurans) 		PF13673
(Acetyltransf_10) 		4 LEU A  66
ASN A  64
PRO A  76
ARG A 134
 LEU  A  66 ( 0.5A)
ASN  A  64 ( 0.6A)
PRO  A  76 ( 1.1A)
ARG  A 134 ( 0.6A)
 1.27A 4yv5A-3s6fA:
undetectable		 4yv5A-3s6fA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sn0 PUTATIVE
L-ALANINE-DL-GLUTAMA
TE EPIMERASE

(Paraburkholderia
xenovorans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 PHE A 183
LEU A 187
ASN A 221
PRO A 177
 None
 1.40A 4yv5A-3sn0A:
undetectable		 4yv5A-3sn0A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttl POLYAMINE TRANSPORT
PROTEIN

(Pseudomonas
aeruginosa) 		PF13416
(SBP_bac_8) 		4 LYS A 102
LEU A 103
ASN A 105
PRO A 104
 None
 1.21A 4yv5A-3ttlA:
undetectable		 4yv5A-3ttlA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vzb SPHINGOSINE KINASE 1

(Homo sapiens) 		PF00781
(DAGK_cat) 		4 LEU A 134
ASN A 114
PRO A 109
ARG A 144
 None
 1.42A 4yv5A-3vzbA:
undetectable		 4yv5A-3vzbA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wme ATP-BINDING
CASSETTE, SUB-FAMILY
B, MEMBER 1

(Cyanidioschyzon
merolae) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 PHE A 243
LEU A 388
PRO A 136
ARG A 181
 None
 1.15A 4yv5A-3wmeA:
undetectable		 4yv5A-3wmeA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING

(Desulfovibrio
vulgaris) 		PF00374
(NiFeSe_Hases) 		4 LEU B 446
ASN B 450
PRO B 319
ARG B 333
 None
 1.44A 4yv5A-3ze7B:
0.4		 4yv5A-3ze7B:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zf8 MANNAN POLYMERASE
COMPLEXES SUBUNIT
MNN9

(Saccharomyces
cerevisiae) 		PF03452
(Anp1) 		4 PHE A 380
LEU A 382
ASN A 384
PRO A 383
 None
 1.45A 4yv5A-3zf8A:
undetectable		 4yv5A-3zf8A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4apl APICAL MEMBRANE
ANTIGEN 1

(Neospora
caninum) 		PF02430
(AMA-1) 		4 PHE A 250
LEU A 149
ASN A 147
PRO A 148
 None
 1.32A 4yv5A-4aplA:
undetectable		 4yv5A-4aplA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ddw REVERSE GYRASE

(Thermotoga
maritima) 		PF00270
(DEAD)
PF01131
(Topoisom_bac)
PF01751
(Toprim) 		4 LEU A 248
ASN A 247
PRO A 245
ARG A 230
 None
 1.44A 4yv5A-4ddwA:
undetectable		 4yv5A-4ddwA:
7.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyk AMIDOHYDROLASE

(Pseudomonas
aeruginosa) 		PF01979
(Amidohydro_1) 		4 LEU A 329
ASN A 284
PRO A 281
ARG A 344
 None
 0.95A 4yv5A-4dykA:
undetectable		 4yv5A-4dykA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e2o ALPHA-AMYLASE

(Geobacillus
thermoleovorans) 		PF00128
(Alpha-amylase) 		4 LYS A 320
ASN A 328
PRO A 329
ARG A 367
 None
 1.31A 4yv5A-4e2oA:
undetectable		 4yv5A-4e2oA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL

(Homo sapiens) 		PF00067
(p450) 		4 PHE A 239
LEU A 113
PRO A 115
ARG A  51
 None
 1.21A 4yv5A-4fdhA:
undetectable		 4yv5A-4fdhA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl0 LMO0810 PROTEIN

(Listeria
monocytogenes) 		PF13416
(SBP_bac_8) 		4 LYS A 110
LEU A 111
ASN A 113
PRO A 112
 None
 1.13A 4yv5A-4gl0A:
undetectable		 4yv5A-4gl0A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gtv GERANYLGERANYL
TRANSFERASE TYPE-2
SUBUNIT ALPHA

(Rattus
norvegicus) 		PF01239
(PPTA) 		4 LEU A  56
ASN A  59
PRO A  60
ARG A 101
 None
 1.40A 4yv5A-4gtvA:
undetectable		 4yv5A-4gtvA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iig BETA-GLUCOSIDASE 1

(Aspergillus
aculeatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 LYS A 394
LEU A 395
ASN A 111
PRO A 107
 None
 1.41A 4yv5A-4iigA:
undetectable		 4yv5A-4iigA:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jb1 UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE

(Pseudomonas
aeruginosa) 		PF01565
(FAD_binding_4)
PF02873
(MurB_C) 		4 PHE A 328
LEU A 332
ASN A 243
PRO A 244
 None
None
NAP  A 402 (-2.8A)
None
 1.16A 4yv5A-4jb1A:
undetectable		 4yv5A-4jb1A:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k28 SHIKIMATE
DEHYDROGENASE FAMILY
PROTEIN

(Pseudomonas
putida) 		PF00899
(ThiF)
PF08501
(Shikimate_dh_N) 		4 PHE A 188
LEU A 207
ASN A 193
ARG A 127
 None
 1.42A 4yv5A-4k28A:
undetectable		 4yv5A-4k28A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4llf CAPSID PROTEIN

(Cucumber
necrosis virus) 		PF00729
(Viral_coat) 		4 PHE A 255
LYS A 148
ASN A 127
PRO A 128
 None
 1.18A 4yv5A-4llfA:
undetectable		 4yv5A-4llfA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4onu ACETYLTRANSFERASE
PAT

(Mycolicibacterium
smegmatis) 		PF00027
(cNMP_binding)
PF13302
(Acetyltransf_3) 		4 PHE A 182
LEU A 192
PRO A 188
ARG A 181
 None
 1.22A 4yv5A-4onuA:
undetectable		 4yv5A-4onuA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rm9 EZRIN

(Homo sapiens) 		PF00373
(FERM_M)
PF00769
(ERM)
PF09379
(FERM_N)
PF09380
(FERM_C) 		4 PHE A  18
LEU A  76
ASN A  74
PRO A  75
 None
 1.23A 4yv5A-4rm9A:
undetectable		 4yv5A-4rm9A:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rma EZRIN

(Homo sapiens) 		PF00373
(FERM_M)
PF09379
(FERM_N)
PF09380
(FERM_C) 		4 PHE A  18
LEU A  76
ASN A  74
PRO A  75
 None
 1.17A 4yv5A-4rmaA:
undetectable		 4yv5A-4rmaA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ru0 PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC
TRANSPORTER,
PERIPLASMIC
BRANCHED-CHAIN AMINO
ACID-BINDING PROTEIN

(Pseudomonas
protegens) 		PF13458
(Peripla_BP_6) 		4 PHE A 154
ASN A 147
PRO A 149
ARG A 238
 None
 1.35A 4yv5A-4ru0A:
undetectable		 4yv5A-4ru0A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u98 MALTOKINASE

(Mycolicibacterium
vanbaalenii) 		PF01636
(APH) 		4 LEU A 331
ASN A 159
PRO A 160
ARG A 342
 None
 1.22A 4yv5A-4u98A:
undetectable		 4yv5A-4u98A:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ufc GH95

(Bacteroides
ovatus) 		PF14498
(Glyco_hyd_65N_2) 		4 LYS A 546
LEU A 547
ASN A 513
PRO A 548
 None
 1.11A 4yv5A-4ufcA:
undetectable		 4yv5A-4ufcA:
10.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wtb BASIC PHOSPHOLIPASE
A2 HOMOLOG
BOTHROPSTOXIN-1

(Bothrops
jararacussu) 		PF00068
(Phospholip_A2_1) 		6 PHE A   3
LYS A   7
LEU A  10
ASN A  16
PRO A  17
ARG A  63
 None
 0.53A 4yv5A-4wtbA:
23.7		 4yv5A-4wtbA:
94.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ye5 PEPTIDOGLYCAN
SYNTHETASE
PENICILLIN-BINDING
PROTEIN 3

(Bifidobacterium
adolescentis) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		4 LYS A 143
LEU A 144
ASN A  89
PRO A  90
 None
 1.21A 4yv5A-4ye5A:
undetectable		 4yv5A-4ye5A:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yiv APICAL MEMBRANE
ANTIGEN AMA1

(Toxoplasma
gondii) 		PF02430
(AMA-1) 		4 PHE A 256
LEU A 155
ASN A 153
PRO A 154
 None
 1.19A 4yv5A-4yivA:
undetectable		 4yv5A-4yivA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a6w AVR-PIK PROTEIN

(Magnaporthe
oryzae) 		no annotation 4 PHE C  57
LEU C  95
ASN C  94
ARG C  64
 None
 1.34A 4yv5A-5a6wC:
undetectable		 4yv5A-5a6wC:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5azb PROLIPOPROTEIN
DIACYLGLYCERYL
TRANSFERASE

(Escherichia
coli) 		PF01790
(LGT) 		4 LEU A 134
ASN A 215
PRO A 133
ARG A 122
 PGT  A 305 ( 4.7A)
None
None
None
 1.42A 4yv5A-5azbA:
undetectable		 4yv5A-5azbA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dl5 MEMBRANE PROTEIN

(Acinetobacter
baumannii) 		PF03573
(OprD) 		4 PHE A 224
LEU A 303
ASN A 305
PRO A 304
 None
 1.00A 4yv5A-5dl5A:
undetectable		 4yv5A-5dl5A:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ik2 ATP SYNTHASE GAMMA
CHAIN

(Caldalkalibacillus
thermarum) 		PF00231
(ATP-synt) 		4 PHE G 238
LYS G 234
LEU G 231
ARG G 241
 None
 1.05A 4yv5A-5ik2G:
undetectable		 4yv5A-5ik2G:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jj7 ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE FICD
HOMOLOG

(Caenorhabditis
elegans) 		PF02661
(Fic) 		4 PHE A 264
LEU A 311
ASN A 419
ARG A 284
 None
 1.37A 4yv5A-5jj7A:
undetectable		 4yv5A-5jj7A:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzx UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE

(Mycobacterium
tuberculosis) 		PF01565
(FAD_binding_4)
PF02873
(MurB_C) 		4 PHE A 354
LEU A 358
ASN A 261
PRO A 262
 None
 1.33A 4yv5A-5jzxA:
undetectable		 4yv5A-5jzxA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m60 BETA-1,3-GLUCANASE

(Chaetomium
thermophilum) 		PF12708
(Pectate_lyase_3) 		4 PHE A 668
ASN A 563
PRO A 662
ARG A 613
 None
 1.13A 4yv5A-5m60A:
undetectable		 4yv5A-5m60A:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5suo EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF12010
(DUF3502) 		4 LYS A 409
LEU A 412
ASN A 155
PRO A 287
 None
None
None
IOD  A 501 ( 4.3A)
 1.38A 4yv5A-5suoA:
undetectable		 4yv5A-5suoA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sz8 HEMOLYSIN

(Proteus
mirabilis) 		PF05860
(Haemagg_act) 		4 LEU A 163
ASN A 161
PRO A 162
ARG A 154
 None
 1.42A 4yv5A-5sz8A:
undetectable		 4yv5A-5sz8A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5szs SPIKE GLYCOPROTEIN

(Human
coronavirus
NL63) 		PF01600
(Corona_S1)
PF01601
(Corona_S2) 		4 LEU A 711
ASN A 713
PRO A 712
ARG A 746
 None
 1.38A 4yv5A-5szsA:
0.8		 4yv5A-5szsA:
6.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5trw PYRIDOXAL KINASE
PDXY

(Paraburkholderia
xenovorans) 		PF08543
(Phos_pyr_kin) 		4 LEU A 149
ASN A 145
PRO A 144
ARG A 133
 None
CL  A 405 (-3.4A)
None
SO4  A 403 (-3.7A)
 1.45A 4yv5A-5trwA:
undetectable		 4yv5A-5trwA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb DNA REPLICATION
LICENSING FACTOR
MCM6

(Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		4 PHE 6 712
ASN 6 683
PRO 6 684
ARG 6 794
 None
AGS  61101 (-1.5A)
None
None
 1.39A 4yv5A-5udb6:
undetectable		 4yv5A-5udb6:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uhp O-GLCNACASE
TIM-BARREL DOMAIN

(Homo sapiens) 		PF07555
(NAGidase) 		4 LYS A 308
LEU A  61
ASN A  91
ARG A 340
 None
 1.02A 4yv5A-5uhpA:
undetectable		 4yv5A-5uhpA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vf3 MAJOR CAPSID PROTEIN

(Escherichia
virus T4) 		PF07068
(Gp23) 		4 PHE A 125
LYS A 256
ASN A 482
PRO A 483
 None
 1.06A 4yv5A-5vf3A:
undetectable		 4yv5A-5vf3A:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlj NUCLEAR DISTRIBUTION
PROTEIN PAC1

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		4 PHE B 407
LEU B 389
ASN B 401
PRO B 402
 None
 1.45A 4yv5A-5vljB:
undetectable		 4yv5A-5vljB:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5waq OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMD

(Neisseria
gonorrhoeae) 		no annotation 4 LEU A 177
ASN A 143
PRO A 140
ARG A 186
 None
 1.41A 4yv5A-5waqA:
undetectable		 4yv5A-5waqA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbf UNCONVENTIONAL
MYOSIN-VIIB

(Homo sapiens) 		PF00373
(FERM_M)
PF00784
(MyTH4) 		4 PHE A1754
LEU A1747
PRO A1743
ARG A1758
 None
 1.39A 4yv5A-5xbfA:
undetectable		 4yv5A-5xbfA:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN

(Homo sapiens) 		PF00415
(RCC1)
PF13540
(RCC1_2) 		4 PHE A  77
LEU A 103
PRO A 161
ARG A  93
 None
 1.33A 4yv5A-5xgsA:
undetectable		 4yv5A-5xgsA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c62 BIURET HYDROLASE

(Pseudomonas sp.
ADP) 		no annotation 4 PHE A 191
ASN A 358
PRO A 434
ARG A 196
 None
 1.44A 4yv5A-6c62A:
undetectable		 4yv5A-6c62A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ce2 -

(-) 		no annotation 5 LYS A   7
LEU A  10
ASN A  17
PRO A  18
ARG A  72
 None
None
None
PE4  A 201 (-4.6A)
None
 0.37A 4yv5A-6ce2A:
24.4		 4yv5A-6ce2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cgm RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Bacillus
subtilis) 		no annotation 4 PHE A 171
LEU A 167
ASN A 158
PRO A 154
 None
 1.39A 4yv5A-6cgmA:
undetectable		 4yv5A-6cgmA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d2k FERM, ARHGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 2

(Mus musculus) 		no annotation 4 PHE A 124
LEU A 220
PRO A 128
ARG A 232
 None
 1.43A 4yv5A-6d2kA:
undetectable		 4yv5A-6d2kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1axk GLUXYN-1

(Bacillus
subtilis) 		PF00457
(Glyco_hydro_11)
PF00722
(Glyco_hydro_16) 		4 TYR A 221
TYR A 236
LEU A 224
PHE A 302
 None
 1.08A 4yv5B-1axkA:
undetectable		 4yv5B-1axkA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b41 ACETYLCHOLINESTERASE

(Homo sapiens) 		PF00135
(COesterase) 		4 ASN A 406
TYR A 337
TYR A 449
PHE A 430
 None
 1.21A 4yv5B-1b41A:
0.0		 4yv5B-1b41A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bwm PROTEIN (ALPHA-BETA
T CELL RECEPTOR
(TCR) (D10))

(Mus musculus) 		PF07686
(V-set) 		4 LYS A 371
LYS A 372
LEU A 375
PHE A 362
 None
 0.92A 4yv5B-1bwmA:
0.0		 4yv5B-1bwmA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f1c CYTOCHROME C549

(Arthrospira
maxima) 		PF14495
(Cytochrom_C550) 		4 LYS A  27
LYS A  28
TYR A 118
LEU A 112
 None
 0.91A 4yv5B-1f1cA:
0.0		 4yv5B-1f1cA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f3j H-2 CLASS II
HISTOCOMPATIBILITY
ANTIGEN

(Mus musculus) 		PF00993
(MHC_II_alpha)
PF07654
(C1-set) 		4 ASN A 118
TYR A 150
LEU A 151
PHE A 153
 NAG  A1002 (-2.2A)
None
None
None
 1.25A 4yv5B-1f3jA:
0.0		 4yv5B-1f3jA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g1s P-SELECTIN

(Homo sapiens) 		PF00008
(EGF)
PF00059
(Lectin_C) 		4 LYS A 112
LYS A 113
TYR A  10
LEU A 116
 None
 1.27A 4yv5B-1g1sA:
0.0		 4yv5B-1g1sA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ggq OUTER SURFACE
PROTEIN C

(Borreliella
burgdorferi) 		PF01441
(Lipoprotein_6) 		4 LYS A 137
TYR A 102
LEU A 173
PHE A 177
 None
 1.22A 4yv5B-1ggqA:
0.8		 4yv5B-1ggqA:
21.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gmz PHOSPHOLIPASE A2

(Bothrops
pirajai) 		PF00068
(Phospholip_A2_1) 		4 ASN A 104
LYS A 105
LYS A 106
LEU A 114
 None
 0.88A 4yv5B-1gmzA:
19.2		 4yv5B-1gmzA:
71.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE

(Sulfolobus
acidocaldarius) 		PF00128
(Alpha-amylase)
PF09196
(DUF1953) 		4 LYS A 614
TYR A 637
LEU A 608
PHE A 605
 None
MLZ  A 638 ( 4.0A)
None
None
 1.11A 4yv5B-1iv8A:
0.0		 4yv5B-1iv8A:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mc3 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Escherichia
coli) 		PF00483
(NTP_transferase) 		4 LYS A  58
TYR A  60
LEU A  65
PHE A  71
 None
 1.14A 4yv5B-1mc3A:
undetectable		 4yv5B-1mc3A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1olp ALPHA-TOXIN

(Clostridium
sardiniense) 		PF00882
(Zn_dep_PLPC)
PF01477
(PLAT) 		4 ASN A 202
LYS A 199
LYS A 198
PHE A  78
 None
 1.18A 4yv5B-1olpA:
undetectable		 4yv5B-1olpA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s5k AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE

(Salmonella
enterica) 		PF00583
(Acetyltransf_1) 		4 ASN A   7
LYS A   8
LEU A  17
PHE A  82
 None
None
None
COA  A 600 (-4.5A)
 0.96A 4yv5B-1s5kA:
undetectable		 4yv5B-1s5kA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sfn CONSERVED
HYPOTHETICAL PROTEIN

(Deinococcus
radiodurans) 		PF05899
(Cupin_3) 		4 ASN A1140
LYS A1155
TYR A1234
LEU A1193
 None
 1.25A 4yv5B-1sfnA:
undetectable		 4yv5B-1sfnA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1su3 INTERSTITIAL
COLLAGENASE

(Homo sapiens) 		PF00045
(Hemopexin)
PF00413
(Peptidase_M10)
PF01471
(PG_binding_1) 		4 ASN A 346
LYS A 347
LEU A 328
PHE A 297
 None
 1.13A 4yv5B-1su3A:
undetectable		 4yv5B-1su3A:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tjy SUGAR TRANSPORT
PROTEIN

(Salmonella
enterica) 		PF13407
(Peripla_BP_4) 		4 ASN A 238
LYS A 236
TYR A 254
PHE A 263
 None
 1.23A 4yv5B-1tjyA:
undetectable		 4yv5B-1tjyA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u3t ALCOHOL
DEHYDROGENASE ALPHA
CHAIN

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ASN A 225
LYS A 226
LYS A 228
LEU A 235
 None
None
NAD  A1377 (-3.1A)
None
 1.13A 4yv5B-1u3tA:
undetectable		 4yv5B-1u3tA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE

(Escherichia
coli) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 ASN A 240
LYS A 245
TYR A 269
LEU A 276
 None
 1.12A 4yv5B-1uagA:
undetectable		 4yv5B-1uagA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)

(Thermus
thermophilus) 		PF02347
(GDC-P) 		4 ASN B 263
TYR B 333
LEU B 327
PHE B 324
 None
 1.24A 4yv5B-1wytB:
undetectable		 4yv5B-1wytB:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfu CALMODULIN-SENSITIVE
ADENYLATE CYCLASE

(Bacillus
anthracis) 		PF03497
(Anthrax_toxA)
PF07737
(ATLF) 		4 ASN A 655
TYR A 704
LEU A 752
PHE A 749
 None
 1.24A 4yv5B-1xfuA:
undetectable		 4yv5B-1xfuA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bvm TOXIN B

(Clostridioides
difficile) 		PF12918
(TcdB_N)
PF12919
(TcdA_TcdB) 		4 ASN A 467
TYR A 474
TYR A 478
LEU A 493
 None
 1.22A 4yv5B-2bvmA:
2.2		 4yv5B-2bvmA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dbr GLYOXYLATE REDUCTASE

(Pyrococcus
horikoshii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 LYS A   1
LYS A   4
LEU A  68
PHE A  62
 None
 1.14A 4yv5B-2dbrA:
undetectable		 4yv5B-2dbrA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g28 PYRUVATE
DEHYDROGENASE E1
COMPONENT

(Escherichia
coli) 		PF00456
(Transketolase_N) 		4 ASN A 695
TYR A 662
TYR A 664
LEU A 484
 None
 0.93A 4yv5B-2g28A:
undetectable		 4yv5B-2g28A:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i8b MINOR NUCLEOPROTEIN
VP30

(Zaire
ebolavirus) 		PF11507
(Transcript_VP30) 		4 LYS A 180
TYR A 211
LEU A 214
PHE A 222
 None
 1.21A 4yv5B-2i8bA:
undetectable		 4yv5B-2i8bA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ig6 NIMC/NIMA FAMILY
PROTEIN

(Clostridium
acetobutylicum) 		PF01243
(Putative_PNPOx) 		4 TYR A  35
TYR A  40
LEU A  39
PHE A 112
 None
 1.16A 4yv5B-2ig6A:
undetectable		 4yv5B-2ig6A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j4e INOSINE TRIPHOSPHATE
PYROPHOSPHATASE

(Homo sapiens) 		PF01725
(Ham1p_like) 		4 ASN A  16
LYS A  18
LYS A  19
LEU A  35
 ITT  A1001 (-3.9A)
None
ITT  A1001 (-2.7A)
None
 1.10A 4yv5B-2j4eA:
undetectable		 4yv5B-2j4eA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j4e INOSINE TRIPHOSPHATE
PYROPHOSPHATASE

(Homo sapiens) 		PF01725
(Ham1p_like) 		4 ASN A  16
LYS A  18
LYS A  19
LEU A  69
 ITT  A1001 (-3.9A)
None
ITT  A1001 (-2.7A)
None
 1.17A 4yv5B-2j4eA:
undetectable		 4yv5B-2j4eA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p24 H-2 CLASS II
HISTOCOMPATIBILITY
ANTIGEN, A-U ALPHA
CHAIN

(Mus musculus) 		PF00993
(MHC_II_alpha)
PF07654
(C1-set) 		4 ASN A 118
TYR A 150
LEU A 151
PHE A 153
 None
 1.24A 4yv5B-2p24A:
undetectable		 4yv5B-2p24A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q4a CLAVAMINATE
SYNTHASE-LIKE
PROTEIN AT3G21360

(Arabidopsis
thaliana) 		PF02668
(TauD) 		4 LYS A 237
TYR A 156
LEU A 312
PHE A 119
 None
 1.18A 4yv5B-2q4aA:
undetectable		 4yv5B-2q4aA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vg9 BIFUNCTIONAL
ENDO-1,4-BETA-XYLANA
SE A

(Neocallimastix
patriciarum) 		PF00457
(Glyco_hydro_11) 		4 ASN A 190
LYS A  66
LEU A  59
PHE A  19
 None
 1.12A 4yv5B-2vg9A:
undetectable		 4yv5B-2vg9A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vl8 CYTOTOXIN L

(Paeniclostridium
sordellii) 		PF12918
(TcdB_N)
PF12919
(TcdA_TcdB) 		4 ASN A 467
TYR A 474
TYR A 478
LEU A 493
 None
 1.24A 4yv5B-2vl8A:
undetectable		 4yv5B-2vl8A:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1q HYALURONOGLUCOSAMINI
DASE

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C) 		4 ASN A 890
TYR A 886
LEU A 926
PHE A 882
 None
 1.11A 4yv5B-2w1qA:
undetectable		 4yv5B-2w1qA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9l POLY-GAMMA-GLUTAMATE
HYDROLASE

(Bacillus virus
NIT1) 		PF05908
(Gamma_PGA_hydro) 		4 ASN A 184
TYR A  53
LEU A  51
PHE A 102
 None
 1.15A 4yv5B-3a9lA:
1.4		 4yv5B-3a9lA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c7o ENDO-1,4-BETA-XYLANA
SE

(Bacillus
subtilis) 		PF03422
(CBM_6)
PF04616
(Glyco_hydro_43) 		4 TYR A 259
TYR A 237
LEU A 229
PHE A 167
 None
 1.06A 4yv5B-3c7oA:
undetectable		 4yv5B-3c7oA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cg3 UPF0100 PROTEIN
PH0151

(Pyrococcus
horikoshii) 		PF13531
(SBP_bac_11) 		4 ASN A 288
LYS A 287
LEU A  30
PHE A  63
 None
 1.20A 4yv5B-3cg3A:
undetectable		 4yv5B-3cg3A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ezy DEHYDROGENASE

(Thermotoga
maritima) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 ASN A 127
TYR A 279
TYR A 283
LEU A 284
 None
 1.00A 4yv5B-3ezyA:
undetectable		 4yv5B-3ezyA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fsn RETINAL PIGMENT
EPITHELIUM-SPECIFIC
65 KDA PROTEIN

(Bos taurus) 		PF03055
(RPE65) 		4 ASN A 156
TYR A 144
TYR A 137
LEU A 529
 None
 1.05A 4yv5B-3fsnA:
undetectable		 4yv5B-3fsnA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7x FEMALE-SPECIFIC
HISTAMINE-BINDING
PROTEIN 2

(Rhipicephalus
appendiculatus) 		PF02098
(His_binding) 		4 ASN A  27
TYR A 141
LEU A 136
PHE A 152
 None
 1.09A 4yv5B-3g7xA:
undetectable		 4yv5B-3g7xA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B

(Sulfolobus
solfataricus) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 LYS B 309
LYS B 311
TYR B 313
TYR B 317
 None
 1.18A 4yv5B-3hkzB:
undetectable		 4yv5B-3hkzB:
7.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hsi PHOSPHATIDYLSERINE
SYNTHASE

(Haemophilus
influenzae) 		PF13091
(PLDc_2) 		4 LYS A 305
TYR A 277
LEU A 332
PHE A 335
 None
 1.15A 4yv5B-3hsiA:
undetectable		 4yv5B-3hsiA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k7y ASPARTATE
AMINOTRANSFERASE

(Plasmodium
falciparum) 		PF00155
(Aminotran_1_2) 		4 LYS A 338
TYR A 343
LEU A 332
PHE A 329
 None
 1.18A 4yv5B-3k7yA:
undetectable		 4yv5B-3k7yA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzq PUTATIVE
UNCHARACTERIZED
PROTEIN VP2116

(Vibrio
parahaemolyticus) 		PF13743
(Thioredoxin_5) 		4 ASN A 205
TYR A   6
LEU A   5
PHE A  36
 None
 1.12A 4yv5B-3kzqA:
undetectable		 4yv5B-3kzqA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzq PUTATIVE
UNCHARACTERIZED
PROTEIN VP2116

(Vibrio
parahaemolyticus) 		PF13743
(Thioredoxin_5) 		4 ASN A 205
TYR A 181
TYR A   6
LEU A   5
 None
 1.21A 4yv5B-3kzqA:
undetectable		 4yv5B-3kzqA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lb9 ENDO-1,4-BETA-XYLANA
SE

(Bacillus
circulans) 		PF00457
(Glyco_hydro_11) 		4 TYR A 130
TYR A 145
LEU A 133
PHE A  25
 None
 1.21A 4yv5B-3lb9A:
undetectable		 4yv5B-3lb9A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lv4 GLYCOSIDE HYDROLASE
YXIA

(Bacillus
licheniformis) 		PF04616
(Glyco_hydro_43)
PF16369
(GH43_C) 		4 ASN A 265
LYS A 264
TYR A 242
TYR A 244
 None
 1.18A 4yv5B-3lv4A:
undetectable		 4yv5B-3lv4A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mst PUTATIVE NITRATE
TRANSPORT PROTEIN

(Thermoplasma
volcanium) 		PF12916
(DUF3834) 		4 ASN A 110
LYS A 107
TYR A  74
PHE A 127
 None
None
None
UNL  A 226 ( 4.6A)
 1.15A 4yv5B-3mstA:
undetectable		 4yv5B-3mstA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT BETA-1

(Sus scrofa) 		PF00287
(Na_K-ATPase) 		4 LYS B 192
TYR B 279
LEU B 209
PHE B 238
 None
 1.04A 4yv5B-3n23B:
undetectable		 4yv5B-3n23B:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3phs CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
agalactiae) 		no annotation 4 LYS A  92
LYS A  91
TYR A 119
LEU A  67
 None
 1.26A 4yv5B-3phsA:
undetectable		 4yv5B-3phsA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q7z BETA-LACTAMASE
REGULATORY PROTEIN
BLAR1

(Staphylococcus
aureus) 		PF00905
(Transpeptidase) 		4 LYS A 466
TYR A 394
LEU A 395
PHE A 442
 None
 1.19A 4yv5B-3q7zA:
undetectable		 4yv5B-3q7zA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qwt PUTATIVE GH105
FAMILY PROTEIN

(Salmonella
enterica) 		PF07470
(Glyco_hydro_88) 		4 LYS A  87
TYR A  77
TYR A  74
LEU A  70
 None
 1.21A 4yv5B-3qwtA:
undetectable		 4yv5B-3qwtA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r3j GLUTAMATE
DEHYDROGENASE

(Plasmodium
falciparum) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 ASN A 349
TYR A 342
TYR A 357
LEU A 354
 None
 0.99A 4yv5B-3r3jA:
undetectable		 4yv5B-3r3jA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rza TRIPEPTIDASE

(Staphylococcus
aureus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 ASN A 359
LYS A 356
TYR A  98
TYR A 100
 None
PG4  A 416 (-2.8A)
None
PEG  A 409 (-3.7A)
 0.79A 4yv5B-3rzaA:
undetectable		 4yv5B-3rzaA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sd7 PUTATIVE PHOSPHATASE

(Clostridioides
difficile) 		PF13419
(HAD_2) 		4 ASN A 101
LYS A 100
TYR A 128
LEU A 106
 None
 0.97A 4yv5B-3sd7A:
undetectable		 4yv5B-3sd7A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sun DNA POLYMERASE

(Escherichia
virus RB69) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 LYS A 279
TYR A 277
TYR A 273
LEU A 271
 None
 1.22A 4yv5B-3sunA:
1.9		 4yv5B-3sunA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tdg PUTATIVE
UNCHARACTERIZED
PROTEIN

(Helicobacter
pylori) 		no annotation 5 ASN A 146
LYS A 147
LYS A 149
TYR A 152
PHE A 259
 None
 1.47A 4yv5B-3tdgA:
undetectable		 4yv5B-3tdgA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqq METHIONYL-TRNA
FORMYLTRANSFERASE

(Coxiella
burnetii) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		4 ASN A  99
LYS A  96
TYR A  32
PHE A   7
 None
 1.17A 4yv5B-3tqqA:
undetectable		 4yv5B-3tqqA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsz RICIN B LECTIN

(Ruminiclostridium
thermocellum) 		PF04616
(Glyco_hydro_43)
PF14200
(RicinB_lectin_2) 		4 TYR A 257
TYR A 241
LEU A 233
PHE A 184
 None
 1.15A 4yv5B-3vszA:
undetectable		 4yv5B-3vszA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vzm ENDO-1,4-BETA-XYLANA
SE

(Bacillus
circulans) 		PF00457
(Glyco_hydro_11) 		4 TYR A  65
TYR A  80
LEU A  68
PHE A 146
 None
 1.06A 4yv5B-3vzmA:
undetectable		 4yv5B-3vzmA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w11 INSULIN RECEPTOR
DOMAINS L1-CR

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain) 		4 ASN E 148
LYS E 121
TYR E  67
LEU E  69
 None
 0.93A 4yv5B-3w11E:
undetectable		 4yv5B-3w11E:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akv SORTING NEXIN-33

(Homo sapiens) 		PF00787
(PX)
PF10456
(BAR_3_WASP_bdg) 		4 LYS A 280
TYR A 274
LEU A 273
PHE A 332
 None
 1.22A 4yv5B-4akvA:
undetectable		 4yv5B-4akvA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c5f MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE C

(Escherichia
coli) 		PF01464
(SLT)
PF11873
(DUF3393) 		4 ASN A 278
TYR A 299
TYR A 345
LEU A 346
 None
 1.13A 4yv5B-4c5fA:
undetectable		 4yv5B-4c5fA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dvz CYTOTOXICITY-ASSOCIA
TED IMMUNODOMINANT
ANTIGEN

(Helicobacter
pylori) 		no annotation 4 ASN A 544
LYS A 499
TYR A 473
LEU A 494
 None
 1.20A 4yv5B-4dvzA:
undetectable		 4yv5B-4dvzA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A

(Homo sapiens) 		PF00069
(Pkinase) 		4 ASN A  85
TYR A  88
LEU A  72
PHE A  69
 None
 1.25A 4yv5B-4fr4A:
undetectable		 4yv5B-4fr4A:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g68 ABC TRANSPORTER

(Caldanaerobius) 		PF01547
(SBP_bac_1) 		4 LYS B 280
LYS B 282
TYR B 144
PHE B 179
 None
 1.23A 4yv5B-4g68B:
1.4		 4yv5B-4g68B:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hfk PUTATIVE CYTOPLASMIC
PROTEIN

(Enterobacter
cloacae) 		PF14113
(Tae4) 		4 ASN A  19
TYR A  52
TYR A  78
PHE A  42
 None
 0.95A 4yv5B-4hfkA:
undetectable		 4yv5B-4hfkA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hfk PUTATIVE CYTOPLASMIC
PROTEIN

(Enterobacter
cloacae) 		PF14113
(Tae4) 		4 ASN A  19
TYR A  52
TYR A  78
PHE A  80
 None
 1.18A 4yv5B-4hfkA:
undetectable		 4yv5B-4hfkA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imd N-ACETYLNEURAMINATE
LYASE

(Pasteurella
multocida) 		PF00701
(DHDPS) 		4 ASN A 157
LYS A 156
TYR A 180
LEU A 184
 None
None
PO4  A 301 (-4.8A)
EDO  A 302 ( 4.8A)
 1.19A 4yv5B-4imdA:
undetectable		 4yv5B-4imdA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4itm TETRAACYLDISACCHARID
E 4'-KINASE

(Aquifex
aeolicus) 		PF02606
(LpxK) 		4 ASN A 238
TYR A 275
LEU A 276
PHE A 292
 None
 1.21A 4yv5B-4itmA:
undetectable		 4yv5B-4itmA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m4w PRIMOSOMAL PROTEIN
DNAI

(Bacillus
subtilis) 		PF01695
(IstB_IS21)
PF07319
(DnaI_N) 		4 ASN J 156
LYS J 160
TYR J 165
LEU J 164
 None
 1.09A 4yv5B-4m4wJ:
undetectable		 4yv5B-4m4wJ:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oo3 HYPOTHETICAL PROTEIN

(Parabacteroides
merdae) 		PF01408
(GFO_IDH_MocA)
PF16490
(Oxidoreduct_C) 		4 LYS A  37
TYR A  64
TYR A  66
LEU A  41
 None
 1.09A 4yv5B-4oo3A:
undetectable		 4yv5B-4oo3A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p37 PUTATIVE POLY(A)
POLYMERASE CATALYTIC
SUBUNIT

(Megavirus
chiliensis) 		no annotation 4 LYS B 235
TYR B 360
TYR B 362
LEU B 244
 None
 1.11A 4yv5B-4p37B:
undetectable		 4yv5B-4p37B:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qb7 UNCHARACTERIZED
PROTEIN

(Bacteroides
vulgatus) 		PF13149
(Mfa_like_1) 		4 ASN A 301
TYR A 223
LEU A 222
PHE A 245
 None
SO4  A 416 (-4.7A)
None
None
 1.25A 4yv5B-4qb7A:
undetectable		 4yv5B-4qb7A:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6y PUTATIVE
2-AMINOETHYLPHOSPHON
ATE-BINDING
PERIPLASMIC PROTEIN

(Salmonella
enterica) 		PF13343
(SBP_bac_6) 		4 LYS A 149
LYS A 151
TYR A 154
LEU A 201
 None
 1.15A 4yv5B-4r6yA:
undetectable		 4yv5B-4r6yA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wep PUTATIVE
OSMOPROTECTANT
UPTAKE SYSTEM
SUBSTRATE-BINDING
PROTEIN OSMF

(Escherichia
coli) 		PF04069
(OpuAC) 		4 ASN A 100
LYS A  99
TYR A 243
PHE A 268
 None
 1.04A 4yv5B-4wepA:
undetectable		 4yv5B-4wepA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xcp NEMATODE FATTY ACID
RETINOID BINDING
PROTEIN

(Necator
americanus) 		PF05823
(Gp-FAR-1) 		4 LYS A 147
TYR A 121
LEU A 139
PHE A 136
 None
 1.26A 4yv5B-4xcpA:
undetectable		 4yv5B-4xcpA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xkq NICKEL ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Staphylococcus
aureus) 		PF00496
(SBP_bac_5) 		4 ASN A 244
LYS A 245
LYS A 246
LEU A 304
 None
 1.25A 4yv5B-4xkqA:
undetectable		 4yv5B-4xkqA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yxm DNA INTEGRITY
SCANNING PROTEIN
DISA

(Thermotoga
maritima) 		PF00633
(HHH)
PF02457
(DisA_N)
PF10635
(DisA-linker) 		4 ASN A  75
TYR A  69
LEU A  68
PHE A  63
 None
 1.23A 4yv5B-4yxmA:
undetectable		 4yv5B-4yxmA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztb PROTEASE NSP2

(Chikungunya
virus) 		PF01707
(Peptidase_C9) 		4 ASN A 173
TYR A 194
TYR A 196
LEU A 198
 None
 1.17A 4yv5B-4ztbA:
undetectable		 4yv5B-4ztbA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8q PUTATIVE RETAINING
B-GLYCOSIDASE

(Saccharophagus
degradans) 		PF00150
(Cellulase) 		4 ASN A 231
TYR A 256
TYR A 312
PHE A 271
 None
BGC  A1367 (-4.6A)
None
None
 1.19A 4yv5B-5a8qA:
undetectable		 4yv5B-5a8qA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aw4 NA+,K+-ATPASE BETA
SUBUNIT

(Squalus
acanthias) 		PF00287
(Na_K-ATPase) 		4 LYS B 193
TYR B 281
LEU B 211
PHE B 240
 None
 0.93A 4yv5B-5aw4B:
undetectable		 4yv5B-5aw4B:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dll AMINOPEPTIDASE N

(Francisella
tularensis) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		4 LYS A 672
LYS A 674
TYR A 680
LEU A 681
 None
 1.01A 4yv5B-5dllA:
1.7		 4yv5B-5dllA:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey7 FRUCTOKINASE

(Vibrio cholerae) 		PF00294
(PfkB) 		4 ASN A 296
LYS A 293
TYR A 274
LEU A 273
 None
 1.19A 4yv5B-5ey7A:
undetectable		 4yv5B-5ey7A:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hsi PUTATIVE
DECARBOXYLASE

(Lactobacillus
brevis) 		PF00282
(Pyridoxal_deC) 		4 ASN A 504
TYR A 508
LEU A 498
PHE A 563
 None
 0.98A 4yv5B-5hsiA:
undetectable		 4yv5B-5hsiA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA

(Homo sapiens) 		no annotation 4 LYS B 619
TYR B 627
TYR B 109
LEU B 108
 None
 1.03A 4yv5B-5iz5B:
undetectable		 4yv5B-5iz5B:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m72 SIGNAL RECOGNITION
PARTICLE SUBUNIT
SRP68
SIGNAL RECOGNITION
PARTICLE SUBUNIT
SRP72

(Homo sapiens) 		PF16969
(SRP68)
PF17004
(SRP_TPR_like) 		4 ASN A  35
LYS A  32
TYR A  21
LEU B 603
 None
None
GOL  A 204 (-3.9A)
None
 1.04A 4yv5B-5m72A:
undetectable		 4yv5B-5m72A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5moy BOTULINUM NEUROTOXIN
TYPE A

(Clostridium
botulinum) 		PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N) 		4 ASN A 912
LYS A 911
TYR A 905
LEU A 916
 None
 1.21A 4yv5B-5moyA:
undetectable		 4yv5B-5moyA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4c PROLYL
OLIGOPEPTIDASE

(Galerina
marginata) 		no annotation 4 LYS A 198
TYR A 172
TYR A 159
PHE A 150
 None
 1.26A 4yv5B-5n4cA:
undetectable		 4yv5B-5n4cA:
10.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5neu INTEGRIN ALPHA-V

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		4 LYS A 369
LYS A 370
TYR A 374
LEU A 391
 None
 1.22A 4yv5B-5neuA:
undetectable		 4yv5B-5neuA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0s GLUCOSYLCERAMIDASE

(Thermoanaerobacterium
xylanolyticum) 		PF04685
(DUF608)
PF12215
(Glyco_hydr_116N)
PF17168
(DUF5127) 		4 ASN A 158
LYS A 175
TYR A 161
TYR A 163
 None
 1.06A 4yv5B-5o0sA:
undetectable		 4yv5B-5o0sA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5of4 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPB
SUBUNIT,XPB,TFIIH
BASAL TRANSCRIPTION
FACTOR COMPLEX
HELICASE XPB SUBUNIT

(Homo sapiens) 		PF04851
(ResIII)
PF16203
(ERCC3_RAD25_C) 		4 ASN A 576
LYS A 577
TYR A 579
PHE A 561
 None
 1.19A 4yv5B-5of4A:
undetectable		 4yv5B-5of4A:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tro PENICILLIN-BINDING
PROTEIN 1

(Staphylococcus
aureus) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		4 LYS A 152
TYR A 147
TYR A  83
LEU A 145
 None
 1.25A 4yv5B-5troA:
undetectable		 4yv5B-5troA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7w APYRASE

(Trifolium
repens) 		PF01150
(GDA1_CD39) 		4 LYS A 173
LYS A 172
TYR A 168
LEU A 201
 None
 0.98A 4yv5B-5u7wA:
undetectable		 4yv5B-5u7wA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8j CYCLIC GMP-AMP
SYNTHASE

(Homo sapiens) 		PF03281
(Mab-21) 		4 LYS A 173
TYR A 415
LEU A 412
PHE A 464
 None
 1.24A 4yv5B-5v8jA:
undetectable		 4yv5B-5v8jA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wti CRISPR-ASSOCIATED
PROTEIN

(Bacillus
thermoamylovorans) 		no annotation 4 ASN Z 398
TYR Z  34
LEU Z 224
PHE Z 227
 None
 1.00A 4yv5B-5wtiZ:
undetectable		 4yv5B-5wtiZ:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xi8 BETA-BARREL
ASSEMBLY-ENHANCING
PROTEASE

(Escherichia
coli) 		no annotation 4 ASN A 357
LYS A 358
TYR A 386
LEU A 387
 None
 1.24A 4yv5B-5xi8A:
undetectable		 4yv5B-5xi8A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z5c CYSTEINE SYNTHASE

(Fusobacterium
nucleatum) 		no annotation 4 ASN A  11
LYS A   6
TYR A 159
LEU A 163
 MLY  A   7 ( 4.4A)
MLY  A   7 ( 1.3A)
None
None
 1.22A 4yv5B-5z5cA:
undetectable		 4yv5B-5z5cA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6az5 ALPHA-AMYLASE

([Eubacterium]
rectale) 		no annotation 4 ASN A 437
TYR A 492
LEU A 490
PHE A 395
 None
 1.07A 4yv5B-6az5A:
undetectable		 4yv5B-6az5A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6beg SCAFFOLD PROTEIN D13

(Vaccinia virus) 		no annotation 4 LYS A 127
TYR A  89
TYR A 116
LEU A 115
 None
 1.23A 4yv5B-6begA:
undetectable		 4yv5B-6begA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bpc RETICULOCYTE BINDING
PROTEIN 2, PUTATIVE

(Plasmodium
vivax) 		no annotation 4 TYR A 186
TYR A 187
LEU A 188
PHE A 435
 None
 1.23A 4yv5B-6bpcA:
undetectable		 4yv5B-6bpcA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4

(Homo sapiens) 		no annotation 4 ASN A 206
TYR A 204
LEU A 173
PHE A 170
 None
 1.14A 4yv5B-6f3dA:
undetectable		 4yv5B-6f3dA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f42 DNA-DIRECTED RNA
POLYMERASES I AND
III SUBUNIT RPAC1

(Saccharomyces
cerevisiae) 		no annotation 4 ASN C   3
TYR C 227
LEU C  56
PHE C  54
 None
 1.24A 4yv5B-6f42C:
undetectable		 4yv5B-6f42C:
20.66