SIMILAR PATTERNS OF AMINO ACIDS FOR 4YV5_A_SVRA205_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a6a HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DR ALPHA
CHAIN

(Homo sapiens) 		PF00993
(MHC_II_alpha)
PF07654
(C1-set) 		4 ASN A 118
TYR A 150
LEU A 151
PHE A 153
 NAG  A 200 (-2.2A)
None
None
None
 1.24A 4yv5A-1a6aA:
0.0		 4yv5A-1a6aA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1axk GLUXYN-1

(Bacillus
subtilis) 		PF00457
(Glyco_hydro_11)
PF00722
(Glyco_hydro_16) 		4 TYR A 221
TYR A 236
LEU A 224
PHE A 302
 None
 1.02A 4yv5A-1axkA:
0.0		 4yv5A-1axkA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cby DELTA-ENDOTOXIN CYTB

(Bacillus
thuringiensis) 		PF01338
(Bac_thur_toxin) 		4 ASN A  76
TYR A 168
LEU A 189
PHE A 173
 None
 1.25A 4yv5A-1cbyA:
0.0		 4yv5A-1cbyA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1k ADRENODOXIN
REDUCTASE

(Bos taurus) 		PF07992
(Pyr_redox_2) 		4 ASN A 351
LYS A 369
TYR A 102
PHE A  19
 None
 1.25A 4yv5A-1e1kA:
1.6		 4yv5A-1e1kA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6y METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
METHYL-COENZYME M
REDUCTASE SUBUNIT
GAMMA

(Methanosarcina
barkeri) 		PF02240
(MCR_gamma)
PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		4 TYR A1448
TYR A1452
LEU A1453
PHE C3223
 None
 0.99A 4yv5A-1e6yA:
0.0		 4yv5A-1e6yA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ecw GAG POLYPROTEIN

(Simian
immunodeficiency
virus) 		PF00540
(Gag_p17) 		4 ASN A  53
LYS A  54
TYR A  79
PHE A  44
 None
 1.17A 4yv5A-1ecwA:
undetectable		 4yv5A-1ecwA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ee2 ALCOHOL
DEHYDROGENASE

(Equus caballus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ASN A 224
LYS A 225
LYS A 227
PHE A 265
 None
None
NAD  A1100 (-4.4A)
None
 1.17A 4yv5A-1ee2A:
undetectable		 4yv5A-1ee2A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f1c CYTOCHROME C549

(Arthrospira
maxima) 		PF14495
(Cytochrom_C550) 		4 LYS A  27
LYS A  28
TYR A 118
LEU A 112
 None
 0.88A 4yv5A-1f1cA:
0.0		 4yv5A-1f1cA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f3j H-2 CLASS II
HISTOCOMPATIBILITY
ANTIGEN

(Mus musculus) 		PF00993
(MHC_II_alpha)
PF07654
(C1-set) 		4 ASN A 118
TYR A 150
LEU A 151
PHE A 153
 NAG  A1002 (-2.2A)
None
None
None
 1.16A 4yv5A-1f3jA:
0.0		 4yv5A-1f3jA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ggq OUTER SURFACE
PROTEIN C

(Borreliella
burgdorferi) 		PF01441
(Lipoprotein_6) 		4 LYS A 137
TYR A 102
LEU A 173
PHE A 177
 None
 1.23A 4yv5A-1ggqA:
undetectable		 4yv5A-1ggqA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE

(Sulfolobus
acidocaldarius) 		PF00128
(Alpha-amylase)
PF09196
(DUF1953) 		4 LYS A 614
TYR A 637
LEU A 608
PHE A 605
 None
MLZ  A 638 ( 4.0A)
None
None
 1.08A 4yv5A-1iv8A:
undetectable		 4yv5A-1iv8A:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mc3 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Escherichia
coli) 		PF00483
(NTP_transferase) 		4 LYS A  58
TYR A  60
LEU A  65
PHE A  71
 None
 1.24A 4yv5A-1mc3A:
undetectable		 4yv5A-1mc3A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oul STRINGENT STARVATION
PROTEIN B HOMOLOG

(Haemophilus
influenzae) 		PF04386
(SspB) 		4 ASN A  23
TYR A  28
LEU A  54
PHE A  71
 None
 1.07A 4yv5A-1oulA:
undetectable		 4yv5A-1oulA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s5k AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE

(Salmonella
enterica) 		PF00583
(Acetyltransf_1) 		4 ASN A   7
LYS A   8
LEU A  17
PHE A  82
 None
None
None
COA  A 600 (-4.5A)
 0.87A 4yv5A-1s5kA:
undetectable		 4yv5A-1s5kA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1suh EPITHELIAL CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		4 ASN A  20
LYS A  61
TYR A  74
LEU A  76
 None
 1.19A 4yv5A-1suhA:
undetectable		 4yv5A-1suhA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE

(Escherichia
coli) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 ASN A 240
LYS A 245
TYR A 269
LEU A 276
 None
 1.21A 4yv5A-1uagA:
undetectable		 4yv5A-1uagA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bvm TOXIN B

(Clostridioides
difficile) 		PF12918
(TcdB_N)
PF12919
(TcdA_TcdB) 		4 ASN A 467
TYR A 474
TYR A 478
LEU A 493
 None
 1.17A 4yv5A-2bvmA:
2.5		 4yv5A-2bvmA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfh TRAFFICKING PROTEIN
PARTICLE COMPLEX
SUBUNIT 6B

(Homo sapiens) 		PF04051
(TRAPP) 		4 ASN C  38
LYS C  35
TYR C 118
LEU C 119
 None
 1.10A 4yv5A-2cfhC:
undetectable		 4yv5A-2cfhC:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ep6 MCTP2 PROTEIN

(Homo sapiens) 		PF00168
(C2) 		4 ASN A 139
LYS A 138
LEU A 110
PHE A 204
 None
 1.23A 4yv5A-2ep6A:
undetectable		 4yv5A-2ep6A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fzw ALCOHOL
DEHYDROGENASE CLASS
III CHI CHAIN

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ASN A 224
LYS A 225
LYS A 227
PHE A 265
 None
None
NAD  A1377 ( 4.8A)
None
 1.23A 4yv5A-2fzwA:
undetectable		 4yv5A-2fzwA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsl HYPOTHETICAL PROTEIN

(Fusobacterium
nucleatum) 		PF00636
(Ribonuclease_3) 		4 ASN A 123
LYS A 120
LYS A 119
LEU A  28
 None
 1.21A 4yv5A-2gslA:
undetectable		 4yv5A-2gslA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mtf LA-RELATED PROTEIN 6

(Homo sapiens) 		PF05383
(La) 		4 ASN A 122
LYS A 123
LEU A 115
PHE A 135
 None
 1.07A 4yv5A-2mtfA:
undetectable		 4yv5A-2mtfA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p24 H-2 CLASS II
HISTOCOMPATIBILITY
ANTIGEN, A-U ALPHA
CHAIN

(Mus musculus) 		PF00993
(MHC_II_alpha)
PF07654
(C1-set) 		4 ASN A 118
TYR A 150
LEU A 151
PHE A 153
 None
 1.25A 4yv5A-2p24A:
undetectable		 4yv5A-2p24A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pa5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 9

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 ASN A 433
TYR A 415
LEU A 429
PHE A 428
 None
 1.21A 4yv5A-2pa5A:
undetectable		 4yv5A-2pa5A:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE

(Lactococcus
lactis) 		PF00232
(Glyco_hydro_1) 		4 ASN A 431
LYS A 435
TYR A 441
PHE A 440
 SO4  A 469 (-4.5A)
SO4  A 469 ( 3.9A)
None
None
 1.25A 4yv5A-2pbgA:
undetectable		 4yv5A-2pbgA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vg9 BIFUNCTIONAL
ENDO-1,4-BETA-XYLANA
SE A

(Neocallimastix
patriciarum) 		PF00457
(Glyco_hydro_11) 		4 ASN A 190
LYS A  66
LEU A  59
PHE A  19
 None
 1.06A 4yv5A-2vg9A:
undetectable		 4yv5A-2vg9A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vl8 CYTOTOXIN L

(Paeniclostridium
sordellii) 		PF12918
(TcdB_N)
PF12919
(TcdA_TcdB) 		4 ASN A 467
TYR A 474
TYR A 478
LEU A 493
 None
 1.21A 4yv5A-2vl8A:
1.9		 4yv5A-2vl8A:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1q HYALURONOGLUCOSAMINI
DASE

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C) 		4 ASN A 890
TYR A 886
LEU A 926
PHE A 882
 None
 1.10A 4yv5A-2w1qA:
undetectable		 4yv5A-2w1qA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9l POLY-GAMMA-GLUTAMATE
HYDROLASE

(Bacillus virus
NIT1) 		PF05908
(Gamma_PGA_hydro) 		4 ASN A 184
TYR A  53
LEU A  51
PHE A 102
 None
 1.08A 4yv5A-3a9lA:
1.4		 4yv5A-3a9lA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bz5 INTERNALIN-J

(Listeria
monocytogenes) 		PF12799
(LRR_4) 		4 LYS A 391
TYR A 373
TYR A 375
LEU A 376
 None
 1.07A 4yv5A-3bz5A:
undetectable		 4yv5A-3bz5A:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c7o ENDO-1,4-BETA-XYLANA
SE

(Bacillus
subtilis) 		PF03422
(CBM_6)
PF04616
(Glyco_hydro_43) 		4 TYR A 259
TYR A 237
LEU A 229
PHE A 167
 None
 1.02A 4yv5A-3c7oA:
undetectable		 4yv5A-3c7oA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM

(Homo sapiens) 		PF00343
(Phosphorylase) 		4 ASN A 101
TYR A  52
LEU A  55
PHE A  31
 None
 1.24A 4yv5A-3cemA:
undetectable		 4yv5A-3cemA:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dah RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE

(Burkholderia
pseudomallei) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		4 ASN A 118
LYS A 114
TYR A  97
LEU A 133
 None
 1.06A 4yv5A-3dahA:
undetectable		 4yv5A-3dahA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dan CYTOCHROME P450 74A2

(Parthenium
argentatum) 		PF00067
(p450) 		4 ASN A 354
LYS A 368
LYS A 367
PHE A  52
 None
 0.94A 4yv5A-3danA:
undetectable		 4yv5A-3danA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ezy DEHYDROGENASE

(Thermotoga
maritima) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 ASN A 127
TYR A 279
TYR A 283
LEU A 284
 None
 0.97A 4yv5A-3ezyA:
undetectable		 4yv5A-3ezyA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7x FEMALE-SPECIFIC
HISTAMINE-BINDING
PROTEIN 2

(Rhipicephalus
appendiculatus) 		PF02098
(His_binding) 		4 ASN A  27
TYR A 141
LEU A 136
PHE A 152
 None
 1.01A 4yv5A-3g7xA:
undetectable		 4yv5A-3g7xA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gri DIHYDROOROTASE

(Staphylococcus
aureus) 		PF01979
(Amidohydro_1) 		4 LYS A 404
TYR A 406
TYR A 334
LEU A 333
 None
 1.18A 4yv5A-3griA:
undetectable		 4yv5A-3griA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h8f CYTOSOL
AMINOPEPTIDASE

(Pseudomonas
putida) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		4 LYS A 224
LYS A 225
TYR A 235
PHE A 454
 None
 1.11A 4yv5A-3h8fA:
undetectable		 4yv5A-3h8fA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k7y ASPARTATE
AMINOTRANSFERASE

(Plasmodium
falciparum) 		PF00155
(Aminotran_1_2) 		4 LYS A 338
TYR A 343
LEU A 332
PHE A 329
 None
 1.11A 4yv5A-3k7yA:
undetectable		 4yv5A-3k7yA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzq PUTATIVE
UNCHARACTERIZED
PROTEIN VP2116

(Vibrio
parahaemolyticus) 		PF13743
(Thioredoxin_5) 		4 ASN A 205
TYR A   6
LEU A   5
PHE A  36
 None
 1.21A 4yv5A-3kzqA:
undetectable		 4yv5A-3kzqA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzq PUTATIVE
UNCHARACTERIZED
PROTEIN VP2116

(Vibrio
parahaemolyticus) 		PF13743
(Thioredoxin_5) 		4 ASN A 205
TYR A 181
TYR A   6
LEU A   5
 None
 1.22A 4yv5A-3kzqA:
undetectable		 4yv5A-3kzqA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lb9 ENDO-1,4-BETA-XYLANA
SE

(Bacillus
circulans) 		PF00457
(Glyco_hydro_11) 		4 TYR A 130
TYR A 145
LEU A 133
PHE A  25
 None
 1.15A 4yv5A-3lb9A:
undetectable		 4yv5A-3lb9A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qwt PUTATIVE GH105
FAMILY PROTEIN

(Salmonella
enterica) 		PF07470
(Glyco_hydro_88) 		4 LYS A  87
TYR A  77
TYR A  74
LEU A  70
 None
 1.25A 4yv5A-3qwtA:
undetectable		 4yv5A-3qwtA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r3j GLUTAMATE
DEHYDROGENASE

(Plasmodium
falciparum) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 ASN A 349
TYR A 342
TYR A 357
LEU A 354
 None
 1.06A 4yv5A-3r3jA:
0.1		 4yv5A-3r3jA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rza TRIPEPTIDASE

(Staphylococcus
aureus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 ASN A 359
LYS A 356
TYR A  98
TYR A 100
 None
PG4  A 416 (-2.8A)
None
PEG  A 409 (-3.7A)
 0.72A 4yv5A-3rzaA:
undetectable		 4yv5A-3rzaA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttk POLYAMINE TRANSPORT
PROTEIN

(Pseudomonas
aeruginosa) 		PF13416
(SBP_bac_8) 		4 LYS A 341
LYS A 340
TYR A 343
LEU A 118
 None
 1.20A 4yv5A-3ttkA:
undetectable		 4yv5A-3ttkA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4t TPR
REPEAT-CONTAINING
PROTEIN

(Cytophaga
hutchinsonii) 		PF07719
(TPR_2) 		4 ASN A 266
TYR A 273
TYR A 278
LEU A 280
 None
 1.17A 4yv5A-3u4tA:
undetectable		 4yv5A-3u4tA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uyq CARBONIC ANHYDRASE 3

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 ASN A 128
LYS A 126
TYR A  88
PHE A  70
 None
 1.24A 4yv5A-3uyqA:
undetectable		 4yv5A-3uyqA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsz RICIN B LECTIN

(Ruminiclostridium
thermocellum) 		PF04616
(Glyco_hydro_43)
PF14200
(RicinB_lectin_2) 		4 TYR A 257
TYR A 241
LEU A 233
PHE A 184
 None
 1.13A 4yv5A-3vszA:
undetectable		 4yv5A-3vszA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vzm ENDO-1,4-BETA-XYLANA
SE

(Bacillus
circulans) 		PF00457
(Glyco_hydro_11) 		4 TYR A  65
TYR A  80
LEU A  68
PHE A 146
 None
 1.00A 4yv5A-3vzmA:
undetectable		 4yv5A-3vzmA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxv PSEUDOAZURIN

(Paracoccus
pantotrophus) 		PF00127
(Copper-bind) 		4 ASN A  41
TYR A  74
LEU A  89
PHE A  22
 None
 1.23A 4yv5A-4bxvA:
undetectable		 4yv5A-4bxvA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c5f MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE C

(Escherichia
coli) 		PF01464
(SLT)
PF11873
(DUF3393) 		4 ASN A 278
TYR A 299
TYR A 345
LEU A 346
 None
 1.16A 4yv5A-4c5fA:
undetectable		 4yv5A-4c5fA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cwe REPLICATION
INITIATION PROTEIN,
REPLICATION
INITIATION PROTEIN

(Staphylococcus
aureus) 		PF02486
(Rep_trans) 		4 ASN A 171
LYS A 173
LEU A 151
PHE A 147
 None
 1.17A 4yv5A-4cweA:
undetectable		 4yv5A-4cweA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czt CBL-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 23

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		4 LYS A  87
TYR A 144
LEU A 138
PHE A 135
 None
 1.12A 4yv5A-4cztA:
undetectable		 4yv5A-4cztA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecg PUTATIVE
IRON-REGULATED
PROTEIN A

(Parabacteroides
distasonis) 		PF09375
(Peptidase_M75) 		4 ASN A 194
LYS A 193
LEU A 177
PHE A 178
 None
 1.14A 4yv5A-4ecgA:
0.4		 4yv5A-4ecgA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euo ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (POLYAMINE)

(Agrobacterium
fabrum) 		PF13416
(SBP_bac_8) 		4 ASN A 313
TYR A 123
TYR A 284
LEU A 303
 None
ABU  A 404 ( 4.0A)
ABU  A 404 (-4.5A)
None
 1.24A 4yv5A-4euoA:
undetectable		 4yv5A-4euoA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f5x RNA-DIRECTED RNA
POLYMERASE

(Rotavirus A) 		PF02123
(RdRP_4)
PF12289
(Rotavirus_VP1) 		4 ASN W 906
LYS W1047
TYR W1044
LEU W 892
 None
 1.22A 4yv5A-4f5xW:
undetectable		 4yv5A-4f5xW:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h3s GLUTAMINE-TRNA
LIGASE

(Saccharomyces
cerevisiae) 		PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C)
PF04557
(tRNA_synt_1c_R2) 		4 ASN A 340
LYS A 342
LEU A 330
PHE A 327
 None
None
None
GOL  A 905 (-4.8A)
 1.11A 4yv5A-4h3sA:
undetectable		 4yv5A-4h3sA:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hfk PUTATIVE CYTOPLASMIC
PROTEIN

(Enterobacter
cloacae) 		PF14113
(Tae4) 		4 ASN A  19
TYR A  52
TYR A  78
PHE A  80
 None
 1.12A 4yv5A-4hfkA:
undetectable		 4yv5A-4hfkA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifq NUCLEOPORIN NUP192

(Saccharomyces
cerevisiae) 		PF11894
(Nup192) 		4 ASN A 557
LYS A 556
LEU A 613
PHE A 341
 None
 1.24A 4yv5A-4ifqA:
undetectable		 4yv5A-4ifqA:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m4w PRIMOSOMAL PROTEIN
DNAI

(Bacillus
subtilis) 		PF01695
(IstB_IS21)
PF07319
(DnaI_N) 		4 ASN J 156
LYS J 160
TYR J 165
LEU J 164
 None
 1.21A 4yv5A-4m4wJ:
undetectable		 4yv5A-4m4wJ:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p37 PUTATIVE POLY(A)
POLYMERASE CATALYTIC
SUBUNIT

(Megavirus
chiliensis) 		no annotation 4 LYS B 235
TYR B 360
TYR B 362
LEU B 244
 None
 1.17A 4yv5A-4p37B:
undetectable		 4yv5A-4p37B:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfw ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF00496
(SBP_bac_5) 		4 ASN A  25
TYR A 222
LEU A 553
PHE A 554
 None
 1.22A 4yv5A-4pfwA:
undetectable		 4yv5A-4pfwA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6y PUTATIVE
2-AMINOETHYLPHOSPHON
ATE-BINDING
PERIPLASMIC PROTEIN

(Salmonella
enterica) 		PF13343
(SBP_bac_6) 		4 LYS A 149
LYS A 151
TYR A 154
LEU A 201
 None
 1.13A 4yv5A-4r6yA:
undetectable		 4yv5A-4r6yA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgq GLYCEROL-1-PHOSPHATE
DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF13685
(Fe-ADH_2) 		4 LYS A 282
LYS A 281
LEU A 292
PHE A 294
 None
 1.23A 4yv5A-4rgqA:
undetectable		 4yv5A-4rgqA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1g QA1 MONOCLONAL
ANTIBODY HEAVY CHAIN
RETICULOCYTE BINDING
PROTEIN 5

(Mus musculus;
Plasmodium
falciparum) 		PF07654
(C1-set)
PF07686
(V-set)
no annotation 		4 LYS B 103
TYR A 346
LEU A 455
PHE A 450
 None
 1.24A 4yv5A-4u1gB:
undetectable		 4yv5A-4u1gB:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xni DI-OR TRIPEPTIDE:H+
SYMPORTER

(Streptococcus
thermophilus) 		PF00854
(PTR2) 		4 ASN A 128
TYR A 194
LEU A 190
PHE A 187
 None
None
None
78M  A 505 ( 3.7A)
 1.23A 4yv5A-4xniA:
undetectable		 4yv5A-4xniA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xqk LLABIII

(Lactococcus
lactis) 		PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII)
PF13156
(Mrr_cat_2) 		4 ASN A 169
TYR A  44
LEU A  40
PHE A  37
 None
 1.14A 4yv5A-4xqkA:
undetectable		 4yv5A-4xqkA:
6.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xqk LLABIII

(Lactococcus
lactis) 		PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII)
PF13156
(Mrr_cat_2) 		4 ASN A1194
LYS A1196
LEU A1102
PHE A1106
 None
 0.75A 4yv5A-4xqkA:
undetectable		 4yv5A-4xqkA:
6.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yxm DNA INTEGRITY
SCANNING PROTEIN
DISA

(Thermotoga
maritima) 		PF00633
(HHH)
PF02457
(DisA_N)
PF10635
(DisA-linker) 		4 ASN A  75
TYR A  69
LEU A  68
PHE A  63
 None
 1.21A 4yv5A-4yxmA:
undetectable		 4yv5A-4yxmA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zmi TELOMERE LENGTH
REGULATOR TAZ1

(Schizosaccharomyces
pombe) 		PF08558
(TRF) 		4 ASN A 168
TYR A 278
LEU A 274
PHE A 271
 None
 1.23A 4yv5A-4zmiA:
undetectable		 4yv5A-4zmiA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztb PROTEASE NSP2

(Chikungunya
virus) 		PF01707
(Peptidase_C9) 		4 ASN A 173
TYR A 194
TYR A 196
LEU A 198
 None
 1.23A 4yv5A-4ztbA:
undetectable		 4yv5A-4ztbA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztu DNA POLYMERASE
SUBUNIT GAMMA-2,
MITOCHONDRIAL

(Homo sapiens) 		PF03129
(HGTP_anticodon) 		4 LYS B 382
TYR B 432
LEU B 372
PHE B 354
 None
 1.10A 4yv5A-4ztuB:
undetectable		 4yv5A-4ztuB:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zze SUGAR BINDING
PROTEIN OF ABC
TRANSPORTER SYSTEM

(Bifidobacterium
animalis) 		PF01547
(SBP_bac_1) 		4 ASN A 172
TYR A 169
LEU A 377
PHE A 372
 None
 1.24A 4yv5A-4zzeA:
undetectable		 4yv5A-4zzeA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8q PUTATIVE RETAINING
B-GLYCOSIDASE

(Saccharophagus
degradans) 		PF00150
(Cellulase) 		4 ASN A 231
TYR A 256
TYR A 312
PHE A 271
 None
BGC  A1367 (-4.6A)
None
None
 1.21A 4yv5A-5a8qA:
undetectable		 4yv5A-5a8qA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aw4 NA+,K+-ATPASE BETA
SUBUNIT

(Squalus
acanthias) 		PF00287
(Na_K-ATPase) 		4 LYS B 193
TYR B 281
LEU B 211
PHE B 240
 None
 0.95A 4yv5A-5aw4B:
undetectable		 4yv5A-5aw4B:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6s EPOXYQUEUOSINE
REDUCTASE

(Streptococcus
thermophilus) 		PF08331
(DUF1730)
PF13484
(Fer4_16) 		4 ASN A 302
LYS A 230
LEU A 292
PHE A 275
 None
 1.08A 4yv5A-5d6sA:
undetectable		 4yv5A-5d6sA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dll AMINOPEPTIDASE N

(Francisella
tularensis) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		4 LYS A 672
LYS A 674
TYR A 680
LEU A 681
 None
 1.17A 4yv5A-5dllA:
undetectable		 4yv5A-5dllA:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hgz N-ALPHA-ACETYLTRANSF
ERASE 60

(Homo sapiens) 		PF00583
(Acetyltransf_1) 		4 ASN A  49
LYS A  50
LYS A  51
LEU A 120
 None
 1.24A 4yv5A-5hgzA:
undetectable		 4yv5A-5hgzA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ica PERIODIC TRYPTOPHAN
PROTEIN 2-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF04003
(Utp12) 		4 ASN D 808
TYR D 769
LEU D 773
PHE D 776
 None
 1.23A 4yv5A-5icaD:
undetectable		 4yv5A-5icaD:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA

(Homo sapiens) 		no annotation 4 LYS B 619
TYR B 627
TYR B 109
LEU B 108
 None
 1.14A 4yv5A-5iz5B:
0.8		 4yv5A-5iz5B:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kxq GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
1

(Mus musculus) 		PF10250
(O-FucT) 		4 ASN A  67
LYS A  64
TYR A  42
LEU A  41
 NAG  A 401 (-1.8A)
None
None
None
 0.99A 4yv5A-5kxqA:
undetectable		 4yv5A-5kxqA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lfn CHONDROADHERIN

(Homo sapiens) 		PF00560
(LRR_1)
PF01462
(LRRNT)
PF13855
(LRR_8) 		4 ASN A 157
TYR A 129
TYR A 105
LEU A  82
 None
 1.22A 4yv5A-5lfnA:
undetectable		 4yv5A-5lfnA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lwi STRUCTURAL
POLYPROTEIN

(Israeli acute
paralysis virus) 		PF00073
(Rhv) 		4 ASN B  87
TYR B 103
TYR B 216
LEU B 151
 None
 1.23A 4yv5A-5lwiB:
undetectable		 4yv5A-5lwiB:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m72 SIGNAL RECOGNITION
PARTICLE SUBUNIT
SRP68
SIGNAL RECOGNITION
PARTICLE SUBUNIT
SRP72

(Homo sapiens) 		PF16969
(SRP68)
PF17004
(SRP_TPR_like) 		4 ASN A  35
LYS A  32
TYR A  21
LEU B 603
 None
None
GOL  A 204 (-3.9A)
None
 1.22A 4yv5A-5m72A:
undetectable		 4yv5A-5m72A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6v AMYLOSUCRASE

(Neisseria
polysaccharea) 		no annotation 4 LYS A  97
TYR A 129
LEU A 127
PHE A 122
 None
 1.21A 4yv5A-5n6vA:
undetectable		 4yv5A-5n6vA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0s GLUCOSYLCERAMIDASE

(Thermoanaerobacterium
xylanolyticum) 		PF04685
(DUF608)
PF12215
(Glyco_hydr_116N)
PF17168
(DUF5127) 		4 ASN A 158
LYS A 175
TYR A 161
TYR A 163
 None
 1.10A 4yv5A-5o0sA:
undetectable		 4yv5A-5o0sA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o6k POLYPHOSPHATE:AMP
PHOSPHOTRANSFERASE

(Meiothermus
ruber) 		no annotation 4 TYR A 206
TYR A 210
LEU A  14
PHE A  12
 None
 1.21A 4yv5A-5o6kA:
undetectable		 4yv5A-5o6kA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olk RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT 1

(Leeuwenhoekiella
blandensis) 		no annotation 4 ASN A 369
LYS A 365
TYR A 235
LEU A 257
 None
 1.15A 4yv5A-5olkA:
0.4		 4yv5A-5olkA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7w APYRASE

(Trifolium
repens) 		PF01150
(GDA1_CD39) 		4 LYS A 173
LYS A 172
TYR A 168
LEU A 201
 None
 1.08A 4yv5A-5u7wA:
undetectable		 4yv5A-5u7wA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8s CELL DIVISION
CONTROL PROTEIN 45

(Saccharomyces
cerevisiae) 		PF02724
(CDC45) 		4 ASN E 342
TYR E 339
TYR E 335
LEU E 334
 None
 1.23A 4yv5A-5u8sE:
undetectable		 4yv5A-5u8sE:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36

(Bos taurus) 		no annotation 4 ASN A 829
LYS A 831
LEU A 713
PHE A 812
 None
 0.95A 4yv5A-5vhaA:
undetectable		 4yv5A-5vhaA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 2

(Homo sapiens) 		PF00004
(AAA) 		4 ASN f 402
LYS f 403
TYR f 439
LEU f 446
 None
 1.14A 4yv5A-5vhif:
undetectable		 4yv5A-5vhif:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x3e KINESIN-LIKE PROTEIN

(Caenorhabditis
elegans) 		PF00225
(Kinesin) 		4 ASN A 346
TYR A 217
LEU A 383
PHE A 387
 None
 1.16A 4yv5A-5x3eA:
undetectable		 4yv5A-5x3eA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z5c CYSTEINE SYNTHASE

(Fusobacterium
nucleatum) 		no annotation 4 ASN A  11
LYS A   6
TYR A 159
LEU A 163
 MLY  A   7 ( 4.4A)
MLY  A   7 ( 1.3A)
None
None
 1.24A 4yv5A-5z5cA:
undetectable		 4yv5A-5z5cA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z5d BETA-XYLOSIDASE

(Geobacillus
thermoleovorans) 		no annotation 4 ASN A 327
TYR A 395
LEU A 392
PHE A 440
 None
 1.24A 4yv5A-5z5dA:
undetectable		 4yv5A-5z5dA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6az5 ALPHA-AMYLASE

([Eubacterium]
rectale) 		no annotation 4 ASN A 437
TYR A 492
LEU A 490
PHE A 395
 None
 0.91A 4yv5A-6az5A:
undetectable		 4yv5A-6az5A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bpc RETICULOCYTE BINDING
PROTEIN 2, PUTATIVE

(Plasmodium
vivax) 		no annotation 4 TYR A 186
TYR A 187
LEU A 188
PHE A 435
 None
 1.24A 4yv5A-6bpcA:
undetectable		 4yv5A-6bpcA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4

(Homo sapiens) 		no annotation 4 ASN A 206
TYR A 204
LEU A 173
PHE A 170
 None
 1.23A 4yv5A-6f3dA:
undetectable		 4yv5A-6f3dA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fai SERINE/THREONINE-PRO
TEIN KINASE RIO2

(Saccharomyces
cerevisiae) 		no annotation 4 ASN l 205
LYS l 208
TYR l 210
PHE l 174
 None
 1.25A 4yv5A-6fail:
undetectable		 4yv5A-6fail:
20.00