SIMILAR PATTERNS OF AMINO ACIDS FOR 4YV5_A_SVRA205

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a6a HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DR ALPHA
CHAIN

(Homo sapiens) 		PF00993
(MHC_II_alpha)
PF07654
(C1-set) 		4 ASN A 118
TYR A 150
LEU A 151
PHE A 153
 NAG  A 200 (-2.2A)
None
None
None
 1.24A 4yv5A-1a6aA:
0.0		 4yv5A-1a6aA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1axk GLUXYN-1

(Bacillus
subtilis) 		PF00457
(Glyco_hydro_11)
PF00722
(Glyco_hydro_16) 		4 TYR A 221
TYR A 236
LEU A 224
PHE A 302
 None
 1.02A 4yv5A-1axkA:
0.0		 4yv5A-1axkA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cby DELTA-ENDOTOXIN CYTB

(Bacillus
thuringiensis) 		PF01338
(Bac_thur_toxin) 		4 ASN A  76
TYR A 168
LEU A 189
PHE A 173
 None
 1.25A 4yv5A-1cbyA:
0.0		 4yv5A-1cbyA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1k ADRENODOXIN
REDUCTASE

(Bos taurus) 		PF07992
(Pyr_redox_2) 		4 ASN A 351
LYS A 369
TYR A 102
PHE A  19
 None
 1.25A 4yv5A-1e1kA:
1.6		 4yv5A-1e1kA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6y METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
METHYL-COENZYME M
REDUCTASE SUBUNIT
GAMMA

(Methanosarcina
barkeri) 		PF02240
(MCR_gamma)
PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		4 TYR A1448
TYR A1452
LEU A1453
PHE C3223
 None
 0.99A 4yv5A-1e6yA:
0.0		 4yv5A-1e6yA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ecw GAG POLYPROTEIN

(Simian
immunodeficiency
virus) 		PF00540
(Gag_p17) 		4 ASN A  53
LYS A  54
TYR A  79
PHE A  44
 None
 1.17A 4yv5A-1ecwA:
undetectable		 4yv5A-1ecwA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ee2 ALCOHOL
DEHYDROGENASE

(Equus caballus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ASN A 224
LYS A 225
LYS A 227
PHE A 265
 None
None
NAD  A1100 (-4.4A)
None
 1.17A 4yv5A-1ee2A:
undetectable		 4yv5A-1ee2A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f1c CYTOCHROME C549

(Arthrospira
maxima) 		PF14495
(Cytochrom_C550) 		4 LYS A  27
LYS A  28
TYR A 118
LEU A 112
 None
 0.88A 4yv5A-1f1cA:
0.0		 4yv5A-1f1cA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f3j H-2 CLASS II
HISTOCOMPATIBILITY
ANTIGEN

(Mus musculus) 		PF00993
(MHC_II_alpha)
PF07654
(C1-set) 		4 ASN A 118
TYR A 150
LEU A 151
PHE A 153
 NAG  A1002 (-2.2A)
None
None
None
 1.16A 4yv5A-1f3jA:
0.0		 4yv5A-1f3jA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ggq OUTER SURFACE
PROTEIN C

(Borreliella
burgdorferi) 		PF01441
(Lipoprotein_6) 		4 LYS A 137
TYR A 102
LEU A 173
PHE A 177
 None
 1.23A 4yv5A-1ggqA:
undetectable		 4yv5A-1ggqA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE

(Sulfolobus
acidocaldarius) 		PF00128
(Alpha-amylase)
PF09196
(DUF1953) 		4 LYS A 614
TYR A 637
LEU A 608
PHE A 605
 None
MLZ  A 638 ( 4.0A)
None
None
 1.08A 4yv5A-1iv8A:
undetectable		 4yv5A-1iv8A:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mc3 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Escherichia
coli) 		PF00483
(NTP_transferase) 		4 LYS A  58
TYR A  60
LEU A  65
PHE A  71
 None
 1.24A 4yv5A-1mc3A:
undetectable		 4yv5A-1mc3A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oul STRINGENT STARVATION
PROTEIN B HOMOLOG

(Haemophilus
influenzae) 		PF04386
(SspB) 		4 ASN A  23
TYR A  28
LEU A  54
PHE A  71
 None
 1.07A 4yv5A-1oulA:
undetectable		 4yv5A-1oulA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s5k AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE

(Salmonella
enterica) 		PF00583
(Acetyltransf_1) 		4 ASN A   7
LYS A   8
LEU A  17
PHE A  82
 None
None
None
COA  A 600 (-4.5A)
 0.87A 4yv5A-1s5kA:
undetectable		 4yv5A-1s5kA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1suh EPITHELIAL CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		4 ASN A  20
LYS A  61
TYR A  74
LEU A  76
 None
 1.19A 4yv5A-1suhA:
undetectable		 4yv5A-1suhA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE

(Escherichia
coli) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 ASN A 240
LYS A 245
TYR A 269
LEU A 276
 None
 1.21A 4yv5A-1uagA:
undetectable		 4yv5A-1uagA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bvm TOXIN B

(Clostridioides
difficile) 		PF12918
(TcdB_N)
PF12919
(TcdA_TcdB) 		4 ASN A 467
TYR A 474
TYR A 478
LEU A 493
 None
 1.17A 4yv5A-2bvmA:
2.5		 4yv5A-2bvmA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfh TRAFFICKING PROTEIN
PARTICLE COMPLEX
SUBUNIT 6B

(Homo sapiens) 		PF04051
(TRAPP) 		4 ASN C  38
LYS C  35
TYR C 118
LEU C 119
 None
 1.10A 4yv5A-2cfhC:
undetectable		 4yv5A-2cfhC:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ep6 MCTP2 PROTEIN

(Homo sapiens) 		PF00168
(C2) 		4 ASN A 139
LYS A 138
LEU A 110
PHE A 204
 None
 1.23A 4yv5A-2ep6A:
undetectable		 4yv5A-2ep6A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fzw ALCOHOL
DEHYDROGENASE CLASS
III CHI CHAIN

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ASN A 224
LYS A 225
LYS A 227
PHE A 265
 None
None
NAD  A1377 ( 4.8A)
None
 1.23A 4yv5A-2fzwA:
undetectable		 4yv5A-2fzwA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsl HYPOTHETICAL PROTEIN

(Fusobacterium
nucleatum) 		PF00636
(Ribonuclease_3) 		4 ASN A 123
LYS A 120
LYS A 119
LEU A  28
 None
 1.21A 4yv5A-2gslA:
undetectable		 4yv5A-2gslA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mtf LA-RELATED PROTEIN 6

(Homo sapiens) 		PF05383
(La) 		4 ASN A 122
LYS A 123
LEU A 115
PHE A 135
 None
 1.07A 4yv5A-2mtfA:
undetectable		 4yv5A-2mtfA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p24 H-2 CLASS II
HISTOCOMPATIBILITY
ANTIGEN, A-U ALPHA
CHAIN

(Mus musculus) 		PF00993
(MHC_II_alpha)
PF07654
(C1-set) 		4 ASN A 118
TYR A 150
LEU A 151
PHE A 153
 None
 1.25A 4yv5A-2p24A:
undetectable		 4yv5A-2p24A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pa5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 9

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 ASN A 433
TYR A 415
LEU A 429
PHE A 428
 None
 1.21A 4yv5A-2pa5A:
undetectable		 4yv5A-2pa5A:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE

(Lactococcus
lactis) 		PF00232
(Glyco_hydro_1) 		4 ASN A 431
LYS A 435
TYR A 441
PHE A 440
 SO4  A 469 (-4.5A)
SO4  A 469 ( 3.9A)
None
None
 1.25A 4yv5A-2pbgA:
undetectable		 4yv5A-2pbgA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vg9 BIFUNCTIONAL
ENDO-1,4-BETA-XYLANA
SE A

(Neocallimastix
patriciarum) 		PF00457
(Glyco_hydro_11) 		4 ASN A 190
LYS A  66
LEU A  59
PHE A  19
 None
 1.06A 4yv5A-2vg9A:
undetectable		 4yv5A-2vg9A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vl8 CYTOTOXIN L

(Paeniclostridium
sordellii) 		PF12918
(TcdB_N)
PF12919
(TcdA_TcdB) 		4 ASN A 467
TYR A 474
TYR A 478
LEU A 493
 None
 1.21A 4yv5A-2vl8A:
1.9		 4yv5A-2vl8A:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1q HYALURONOGLUCOSAMINI
DASE

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C) 		4 ASN A 890
TYR A 886
LEU A 926
PHE A 882
 None
 1.10A 4yv5A-2w1qA:
undetectable		 4yv5A-2w1qA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9l POLY-GAMMA-GLUTAMATE
HYDROLASE

(Bacillus virus
NIT1) 		PF05908
(Gamma_PGA_hydro) 		4 ASN A 184
TYR A  53
LEU A  51
PHE A 102
 None
 1.08A 4yv5A-3a9lA:
1.4		 4yv5A-3a9lA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bz5 INTERNALIN-J

(Listeria
monocytogenes) 		PF12799
(LRR_4) 		4 LYS A 391
TYR A 373
TYR A 375
LEU A 376
 None
 1.07A 4yv5A-3bz5A:
undetectable		 4yv5A-3bz5A:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c7o ENDO-1,4-BETA-XYLANA
SE

(Bacillus
subtilis) 		PF03422
(CBM_6)
PF04616
(Glyco_hydro_43) 		4 TYR A 259
TYR A 237
LEU A 229
PHE A 167
 None
 1.02A 4yv5A-3c7oA:
undetectable		 4yv5A-3c7oA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM

(Homo sapiens) 		PF00343
(Phosphorylase) 		4 ASN A 101
TYR A  52
LEU A  55
PHE A  31
 None
 1.24A 4yv5A-3cemA:
undetectable		 4yv5A-3cemA:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dah RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE

(Burkholderia
pseudomallei) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		4 ASN A 118
LYS A 114
TYR A  97
LEU A 133
 None
 1.06A 4yv5A-3dahA:
undetectable		 4yv5A-3dahA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dan CYTOCHROME P450 74A2

(Parthenium
argentatum) 		PF00067
(p450) 		4 ASN A 354
LYS A 368
LYS A 367
PHE A  52
 None
 0.94A 4yv5A-3danA:
undetectable		 4yv5A-3danA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ezy DEHYDROGENASE

(Thermotoga
maritima) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 ASN A 127
TYR A 279
TYR A 283
LEU A 284
 None
 0.97A 4yv5A-3ezyA:
undetectable		 4yv5A-3ezyA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7x FEMALE-SPECIFIC
HISTAMINE-BINDING
PROTEIN 2

(Rhipicephalus
appendiculatus) 		PF02098
(His_binding) 		4 ASN A  27
TYR A 141
LEU A 136
PHE A 152
 None
 1.01A 4yv5A-3g7xA:
undetectable		 4yv5A-3g7xA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gri DIHYDROOROTASE

(Staphylococcus
aureus) 		PF01979
(Amidohydro_1) 		4 LYS A 404
TYR A 406
TYR A 334
LEU A 333
 None
 1.18A 4yv5A-3griA:
undetectable		 4yv5A-3griA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h8f CYTOSOL
AMINOPEPTIDASE

(Pseudomonas
putida) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		4 LYS A 224
LYS A 225
TYR A 235
PHE A 454
 None
 1.11A 4yv5A-3h8fA:
undetectable		 4yv5A-3h8fA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k7y ASPARTATE
AMINOTRANSFERASE

(Plasmodium
falciparum) 		PF00155
(Aminotran_1_2) 		4 LYS A 338
TYR A 343
LEU A 332
PHE A 329
 None
 1.11A 4yv5A-3k7yA:
undetectable		 4yv5A-3k7yA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzq PUTATIVE
UNCHARACTERIZED
PROTEIN VP2116

(Vibrio
parahaemolyticus) 		PF13743
(Thioredoxin_5) 		4 ASN A 205
TYR A   6
LEU A   5
PHE A  36
 None
 1.21A 4yv5A-3kzqA:
undetectable		 4yv5A-3kzqA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzq PUTATIVE
UNCHARACTERIZED
PROTEIN VP2116

(Vibrio
parahaemolyticus) 		PF13743
(Thioredoxin_5) 		4 ASN A 205
TYR A 181
TYR A   6
LEU A   5
 None
 1.22A 4yv5A-3kzqA:
undetectable		 4yv5A-3kzqA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lb9 ENDO-1,4-BETA-XYLANA
SE

(Bacillus
circulans) 		PF00457
(Glyco_hydro_11) 		4 TYR A 130
TYR A 145
LEU A 133
PHE A  25
 None
 1.15A 4yv5A-3lb9A:
undetectable		 4yv5A-3lb9A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qwt PUTATIVE GH105
FAMILY PROTEIN

(Salmonella
enterica) 		PF07470
(Glyco_hydro_88) 		4 LYS A  87
TYR A  77
TYR A  74
LEU A  70
 None
 1.25A 4yv5A-3qwtA:
undetectable		 4yv5A-3qwtA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r3j GLUTAMATE
DEHYDROGENASE

(Plasmodium
falciparum) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 ASN A 349
TYR A 342
TYR A 357
LEU A 354
 None
 1.06A 4yv5A-3r3jA:
0.1		 4yv5A-3r3jA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rza TRIPEPTIDASE

(Staphylococcus
aureus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 ASN A 359
LYS A 356
TYR A  98
TYR A 100
 None
PG4  A 416 (-2.8A)
None
PEG  A 409 (-3.7A)
 0.72A 4yv5A-3rzaA:
undetectable		 4yv5A-3rzaA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttk POLYAMINE TRANSPORT
PROTEIN

(Pseudomonas
aeruginosa) 		PF13416
(SBP_bac_8) 		4 LYS A 341
LYS A 340
TYR A 343
LEU A 118
 None
 1.20A 4yv5A-3ttkA:
undetectable		 4yv5A-3ttkA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4t TPR
REPEAT-CONTAINING
PROTEIN

(Cytophaga
hutchinsonii) 		PF07719
(TPR_2) 		4 ASN A 266
TYR A 273
TYR A 278
LEU A 280
 None
 1.17A 4yv5A-3u4tA:
undetectable		 4yv5A-3u4tA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uyq CARBONIC ANHYDRASE 3

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 ASN A 128
LYS A 126
TYR A  88
PHE A  70
 None
 1.24A 4yv5A-3uyqA:
undetectable		 4yv5A-3uyqA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsz RICIN B LECTIN

(Ruminiclostridium
thermocellum) 		PF04616
(Glyco_hydro_43)
PF14200
(RicinB_lectin_2) 		4 TYR A 257
TYR A 241
LEU A 233
PHE A 184
 None
 1.13A 4yv5A-3vszA:
undetectable		 4yv5A-3vszA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vzm ENDO-1,4-BETA-XYLANA
SE

(Bacillus
circulans) 		PF00457
(Glyco_hydro_11) 		4 TYR A  65
TYR A  80
LEU A  68
PHE A 146
 None
 1.00A 4yv5A-3vzmA:
undetectable		 4yv5A-3vzmA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxv PSEUDOAZURIN

(Paracoccus
pantotrophus) 		PF00127
(Copper-bind) 		4 ASN A  41
TYR A  74
LEU A  89
PHE A  22
 None
 1.23A 4yv5A-4bxvA:
undetectable		 4yv5A-4bxvA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c5f MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE C

(Escherichia
coli) 		PF01464
(SLT)
PF11873
(DUF3393) 		4 ASN A 278
TYR A 299
TYR A 345
LEU A 346
 None
 1.16A 4yv5A-4c5fA:
undetectable		 4yv5A-4c5fA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cwe REPLICATION
INITIATION PROTEIN,
REPLICATION
INITIATION PROTEIN

(Staphylococcus
aureus) 		PF02486
(Rep_trans) 		4 ASN A 171
LYS A 173
LEU A 151
PHE A 147
 None
 1.17A 4yv5A-4cweA:
undetectable		 4yv5A-4cweA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czt CBL-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 23

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		4 LYS A  87
TYR A 144
LEU A 138
PHE A 135
 None
 1.12A 4yv5A-4cztA:
undetectable		 4yv5A-4cztA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecg PUTATIVE
IRON-REGULATED
PROTEIN A

(Parabacteroides
distasonis) 		PF09375
(Peptidase_M75) 		4 ASN A 194
LYS A 193
LEU A 177
PHE A 178
 None
 1.14A 4yv5A-4ecgA:
0.4		 4yv5A-4ecgA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euo ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (POLYAMINE)

(Agrobacterium
fabrum) 		PF13416
(SBP_bac_8) 		4 ASN A 313
TYR A 123
TYR A 284
LEU A 303
 None
ABU  A 404 ( 4.0A)
ABU  A 404 (-4.5A)
None
 1.24A 4yv5A-4euoA:
undetectable		 4yv5A-4euoA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f5x RNA-DIRECTED RNA
POLYMERASE

(Rotavirus A) 		PF02123
(RdRP_4)
PF12289
(Rotavirus_VP1) 		4 ASN W 906
LYS W1047
TYR W1044
LEU W 892
 None
 1.22A 4yv5A-4f5xW:
undetectable		 4yv5A-4f5xW:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h3s GLUTAMINE-TRNA
LIGASE

(Saccharomyces
cerevisiae) 		PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C)
PF04557
(tRNA_synt_1c_R2) 		4 ASN A 340
LYS A 342
LEU A 330
PHE A 327
 None
None
None
GOL  A 905 (-4.8A)
 1.11A 4yv5A-4h3sA:
undetectable		 4yv5A-4h3sA:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hfk PUTATIVE CYTOPLASMIC
PROTEIN

(Enterobacter
cloacae) 		PF14113
(Tae4) 		4 ASN A  19
TYR A  52
TYR A  78
PHE A  80
 None
 1.12A 4yv5A-4hfkA:
undetectable		 4yv5A-4hfkA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifq NUCLEOPORIN NUP192

(Saccharomyces
cerevisiae) 		PF11894
(Nup192) 		4 ASN A 557
LYS A 556
LEU A 613
PHE A 341
 None
 1.24A 4yv5A-4ifqA:
undetectable		 4yv5A-4ifqA:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m4w PRIMOSOMAL PROTEIN
DNAI

(Bacillus
subtilis) 		PF01695
(IstB_IS21)
PF07319
(DnaI_N) 		4 ASN J 156
LYS J 160
TYR J 165
LEU J 164
 None
 1.21A 4yv5A-4m4wJ:
undetectable		 4yv5A-4m4wJ:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p37 PUTATIVE POLY(A)
POLYMERASE CATALYTIC
SUBUNIT

(Megavirus
chiliensis) 		no annotation 4 LYS B 235
TYR B 360
TYR B 362
LEU B 244
 None
 1.17A 4yv5A-4p37B:
undetectable		 4yv5A-4p37B:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfw ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF00496
(SBP_bac_5) 		4 ASN A  25
TYR A 222
LEU A 553
PHE A 554
 None
 1.22A 4yv5A-4pfwA:
undetectable		 4yv5A-4pfwA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6y PUTATIVE
2-AMINOETHYLPHOSPHON
ATE-BINDING
PERIPLASMIC PROTEIN

(Salmonella
enterica) 		PF13343
(SBP_bac_6) 		4 LYS A 149
LYS A 151
TYR A 154
LEU A 201
 None
 1.13A 4yv5A-4r6yA:
undetectable		 4yv5A-4r6yA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgq GLYCEROL-1-PHOSPHATE
DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF13685
(Fe-ADH_2) 		4 LYS A 282
LYS A 281
LEU A 292
PHE A 294
 None
 1.23A 4yv5A-4rgqA:
undetectable		 4yv5A-4rgqA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1g QA1 MONOCLONAL
ANTIBODY HEAVY CHAIN
RETICULOCYTE BINDING
PROTEIN 5

(Mus musculus;
Plasmodium
falciparum) 		PF07654
(C1-set)
PF07686
(V-set)
no annotation 		4 LYS B 103
TYR A 346
LEU A 455
PHE A 450
 None
 1.24A 4yv5A-4u1gB:
undetectable		 4yv5A-4u1gB:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xni DI-OR TRIPEPTIDE:H+
SYMPORTER

(Streptococcus
thermophilus) 		PF00854
(PTR2) 		4 ASN A 128
TYR A 194
LEU A 190
PHE A 187
 None
None
None
78M  A 505 ( 3.7A)
 1.23A 4yv5A-4xniA:
undetectable		 4yv5A-4xniA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xqk LLABIII

(Lactococcus
lactis) 		PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII)
PF13156
(Mrr_cat_2) 		4 ASN A 169
TYR A  44
LEU A  40
PHE A  37
 None
 1.14A 4yv5A-4xqkA:
undetectable		 4yv5A-4xqkA:
6.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xqk LLABIII

(Lactococcus
lactis) 		PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII)
PF13156
(Mrr_cat_2) 		4 ASN A1194
LYS A1196
LEU A1102
PHE A1106
 None
 0.75A 4yv5A-4xqkA:
undetectable		 4yv5A-4xqkA:
6.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yxm DNA INTEGRITY
SCANNING PROTEIN
DISA

(Thermotoga
maritima) 		PF00633
(HHH)
PF02457
(DisA_N)
PF10635
(DisA-linker) 		4 ASN A  75
TYR A  69
LEU A  68
PHE A  63
 None
 1.21A 4yv5A-4yxmA:
undetectable		 4yv5A-4yxmA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zmi TELOMERE LENGTH
REGULATOR TAZ1

(Schizosaccharomyces
pombe) 		PF08558
(TRF) 		4 ASN A 168
TYR A 278
LEU A 274
PHE A 271
 None
 1.23A 4yv5A-4zmiA:
undetectable		 4yv5A-4zmiA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztb PROTEASE NSP2

(Chikungunya
virus) 		PF01707
(Peptidase_C9) 		4 ASN A 173
TYR A 194
TYR A 196
LEU A 198
 None
 1.23A 4yv5A-4ztbA:
undetectable		 4yv5A-4ztbA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztu DNA POLYMERASE
SUBUNIT GAMMA-2,
MITOCHONDRIAL

(Homo sapiens) 		PF03129
(HGTP_anticodon) 		4 LYS B 382
TYR B 432
LEU B 372
PHE B 354
 None
 1.10A 4yv5A-4ztuB:
undetectable		 4yv5A-4ztuB:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zze SUGAR BINDING
PROTEIN OF ABC
TRANSPORTER SYSTEM

(Bifidobacterium
animalis) 		PF01547
(SBP_bac_1) 		4 ASN A 172
TYR A 169
LEU A 377
PHE A 372
 None
 1.24A 4yv5A-4zzeA:
undetectable		 4yv5A-4zzeA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8q PUTATIVE RETAINING
B-GLYCOSIDASE

(Saccharophagus
degradans) 		PF00150
(Cellulase) 		4 ASN A 231
TYR A 256
TYR A 312
PHE A 271
 None
BGC  A1367 (-4.6A)
None
None
 1.21A 4yv5A-5a8qA:
undetectable		 4yv5A-5a8qA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aw4 NA+,K+-ATPASE BETA
SUBUNIT

(Squalus
acanthias) 		PF00287
(Na_K-ATPase) 		4 LYS B 193
TYR B 281
LEU B 211
PHE B 240
 None
 0.95A 4yv5A-5aw4B:
undetectable		 4yv5A-5aw4B:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6s EPOXYQUEUOSINE
REDUCTASE

(Streptococcus
thermophilus) 		PF08331
(DUF1730)
PF13484
(Fer4_16) 		4 ASN A 302
LYS A 230
LEU A 292
PHE A 275
 None
 1.08A 4yv5A-5d6sA:
undetectable		 4yv5A-5d6sA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dll AMINOPEPTIDASE N

(Francisella
tularensis) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		4 LYS A 672
LYS A 674
TYR A 680
LEU A 681
 None
 1.17A 4yv5A-5dllA:
undetectable		 4yv5A-5dllA:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hgz N-ALPHA-ACETYLTRANSF
ERASE 60

(Homo sapiens) 		PF00583
(Acetyltransf_1) 		4 ASN A  49
LYS A  50
LYS A  51
LEU A 120
 None
 1.24A 4yv5A-5hgzA:
undetectable		 4yv5A-5hgzA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ica PERIODIC TRYPTOPHAN
PROTEIN 2-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF04003
(Utp12) 		4 ASN D 808
TYR D 769
LEU D 773
PHE D 776
 None
 1.23A 4yv5A-5icaD:
undetectable		 4yv5A-5icaD:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA

(Homo sapiens) 		no annotation 4 LYS B 619
TYR B 627
TYR B 109
LEU B 108
 None
 1.14A 4yv5A-5iz5B:
0.8		 4yv5A-5iz5B:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kxq GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
1

(Mus musculus) 		PF10250
(O-FucT) 		4 ASN A  67
LYS A  64
TYR A  42
LEU A  41
 NAG  A 401 (-1.8A)
None
None
None
 0.99A 4yv5A-5kxqA:
undetectable		 4yv5A-5kxqA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lfn CHONDROADHERIN

(Homo sapiens) 		PF00560
(LRR_1)
PF01462
(LRRNT)
PF13855
(LRR_8) 		4 ASN A 157
TYR A 129
TYR A 105
LEU A  82
 None
 1.22A 4yv5A-5lfnA:
undetectable		 4yv5A-5lfnA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lwi STRUCTURAL
POLYPROTEIN

(Israeli acute
paralysis virus) 		PF00073
(Rhv) 		4 ASN B  87
TYR B 103
TYR B 216
LEU B 151
 None
 1.23A 4yv5A-5lwiB:
undetectable		 4yv5A-5lwiB:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m72 SIGNAL RECOGNITION
PARTICLE SUBUNIT
SRP68
SIGNAL RECOGNITION
PARTICLE SUBUNIT
SRP72

(Homo sapiens) 		PF16969
(SRP68)
PF17004
(SRP_TPR_like) 		4 ASN A  35
LYS A  32
TYR A  21
LEU B 603
 None
None
GOL  A 204 (-3.9A)
None
 1.22A 4yv5A-5m72A:
undetectable		 4yv5A-5m72A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6v AMYLOSUCRASE

(Neisseria
polysaccharea) 		no annotation 4 LYS A  97
TYR A 129
LEU A 127
PHE A 122
 None
 1.21A 4yv5A-5n6vA:
undetectable		 4yv5A-5n6vA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0s GLUCOSYLCERAMIDASE

(Thermoanaerobacterium
xylanolyticum) 		PF04685
(DUF608)
PF12215
(Glyco_hydr_116N)
PF17168
(DUF5127) 		4 ASN A 158
LYS A 175
TYR A 161
TYR A 163
 None
 1.10A 4yv5A-5o0sA:
undetectable		 4yv5A-5o0sA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o6k POLYPHOSPHATE:AMP
PHOSPHOTRANSFERASE

(Meiothermus
ruber) 		no annotation 4 TYR A 206
TYR A 210
LEU A  14
PHE A  12
 None
 1.21A 4yv5A-5o6kA:
undetectable		 4yv5A-5o6kA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olk RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT 1

(Leeuwenhoekiella
blandensis) 		no annotation 4 ASN A 369
LYS A 365
TYR A 235
LEU A 257
 None
 1.15A 4yv5A-5olkA:
0.4		 4yv5A-5olkA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7w APYRASE

(Trifolium
repens) 		PF01150
(GDA1_CD39) 		4 LYS A 173
LYS A 172
TYR A 168
LEU A 201
 None
 1.08A 4yv5A-5u7wA:
undetectable		 4yv5A-5u7wA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8s CELL DIVISION
CONTROL PROTEIN 45

(Saccharomyces
cerevisiae) 		PF02724
(CDC45) 		4 ASN E 342
TYR E 339
TYR E 335
LEU E 334
 None
 1.23A 4yv5A-5u8sE:
undetectable		 4yv5A-5u8sE:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36

(Bos taurus) 		no annotation 4 ASN A 829
LYS A 831
LEU A 713
PHE A 812
 None
 0.95A 4yv5A-5vhaA:
undetectable		 4yv5A-5vhaA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 2

(Homo sapiens) 		PF00004
(AAA) 		4 ASN f 402
LYS f 403
TYR f 439
LEU f 446
 None
 1.14A 4yv5A-5vhif:
undetectable		 4yv5A-5vhif:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x3e KINESIN-LIKE PROTEIN

(Caenorhabditis
elegans) 		PF00225
(Kinesin) 		4 ASN A 346
TYR A 217
LEU A 383
PHE A 387
 None
 1.16A 4yv5A-5x3eA:
undetectable		 4yv5A-5x3eA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z5c CYSTEINE SYNTHASE

(Fusobacterium
nucleatum) 		no annotation 4 ASN A  11
LYS A   6
TYR A 159
LEU A 163
 MLY  A   7 ( 4.4A)
MLY  A   7 ( 1.3A)
None
None
 1.24A 4yv5A-5z5cA:
undetectable		 4yv5A-5z5cA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z5d BETA-XYLOSIDASE

(Geobacillus
thermoleovorans) 		no annotation 4 ASN A 327
TYR A 395
LEU A 392
PHE A 440
 None
 1.24A 4yv5A-5z5dA:
undetectable		 4yv5A-5z5dA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6az5 ALPHA-AMYLASE

([Eubacterium]
rectale) 		no annotation 4 ASN A 437
TYR A 492
LEU A 490
PHE A 395
 None
 0.91A 4yv5A-6az5A:
undetectable		 4yv5A-6az5A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bpc RETICULOCYTE BINDING
PROTEIN 2, PUTATIVE

(Plasmodium
vivax) 		no annotation 4 TYR A 186
TYR A 187
LEU A 188
PHE A 435
 None
 1.24A 4yv5A-6bpcA:
undetectable		 4yv5A-6bpcA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4

(Homo sapiens) 		no annotation 4 ASN A 206
TYR A 204
LEU A 173
PHE A 170
 None
 1.23A 4yv5A-6f3dA:
undetectable		 4yv5A-6f3dA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fai SERINE/THREONINE-PRO
TEIN KINASE RIO2

(Saccharomyces
cerevisiae) 		no annotation 4 ASN l 205
LYS l 208
TYR l 210
PHE l 174
 None
 1.25A 4yv5A-6fail:
undetectable		 4yv5A-6fail:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3r HDLP (HISTONE
DEACETYLASE-LIKE
PROTEIN)

(Aquifex
aeolicus) 		PF00850
(Hist_deacetyl) 		4 LEU A   6
ASN A 125
PRO A 126
ARG A  33
 None
 1.29A 4yv5B-1c3rA:
0.0		 4yv5B-1c3rA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
PF03173
(CHB_HEX)
PF03174
(CHB_HEX_C) 		4 LEU A 205
ASN A 800
PRO A 838
ARG A 825
 None
 1.37A 4yv5B-1c7tA:
0.0		 4yv5B-1c7tA:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cc1 HYDROGENASE (LARGE
SUBUNIT)

(Desulfomicrobium
baculatum) 		PF00374
(NiFeSe_Hases) 		4 LEU L 449
ASN L 453
PRO L 323
ARG L 337
 None
 1.35A 4yv5B-1cc1L:
undetectable		 4yv5B-1cc1L:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eh6 O6-ALKYLGUANINE-DNA
ALKYLTRANSFERASE

(Homo sapiens) 		PF01035
(DNA_binding_1)
PF02870
(Methyltransf_1N) 		4 LYS A  32
ASN A 137
PRO A 140
ARG A   9
 None
 1.41A 4yv5B-1eh6A:
undetectable		 4yv5B-1eh6A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gqj ALPHA-D-GLUCURONIDAS
E

(Cellvibrio
japonicus) 		PF03648
(Glyco_hydro_67N)
PF07477
(Glyco_hydro_67C)
PF07488
(Glyco_hydro_67M) 		4 PHE A 221
LEU A 182
ASN A 184
PRO A 183
 None
 1.40A 4yv5B-1gqjA:
undetectable		 4yv5B-1gqjA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gux RETINOBLASTOMA
PROTEIN

(Homo sapiens) 		PF01858
(RB_A) 		4 PHE A 473
LYS A 472
ASN A 410
PRO A 411
 None
 1.27A 4yv5B-1guxA:
0.7		 4yv5B-1guxA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h5y HISF

(Pyrobaculum
aerophilum) 		PF00977
(His_biosynth) 		4 PHE A  65
LEU A  11
PRO A  35
ARG A  62
 None
 1.38A 4yv5B-1h5yA:
undetectable		 4yv5B-1h5yA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE

(Sus scrofa) 		PF01180
(DHO_dh)
PF07992
(Pyr_redox_2)
PF14691
(Fer4_20)
PF14697
(Fer4_21) 		4 LEU A 834
ASN A 544
PRO A 545
ARG A 771
 None
 1.34A 4yv5B-1h7wA:
0.0		 4yv5B-1h7wA:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ile ISOLEUCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		4 PHE A 710
LEU A 646
ASN A 648
ARG A 683
 None
 1.41A 4yv5B-1ileA:
undetectable		 4yv5B-1ileA:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jed SULFATE
ADENYLYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 PHE A 255
LEU A 258
PRO A 223
ARG A 186
 None
None
None
ACY  A 555 (-3.5A)
 1.23A 4yv5B-1jedA:
undetectable		 4yv5B-1jedA:
12.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mc2 ACUTOHAEMONLYSIN

(Deinagkistrodon
acutus) 		PF00068
(Phospholip_A2_1) 		4 LYS A1007
ASN A1016
PRO A1017
ARG A1072
 None
None
IPA  A1136 (-4.4A)
None
 0.67A 4yv5B-1mc2A:
24.2		 4yv5B-1mc2A:
77.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p2x RAS
GTPASE-ACTIVATING-LI
KE PROTEIN

(Schizosaccharomyces
pombe) 		PF00307
(CH) 		4 LEU A 133
ASN A 132
PRO A 134
ARG A 175
 None
None
BR  A 194 ( 4.9A)
BR  A 201 (-3.6A)
 1.21A 4yv5B-1p2xA:
undetectable		 4yv5B-1p2xA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8w AMP NUCLEOSIDASE

(Escherichia
coli) 		PF01048
(PNP_UDP_1)
PF10423
(AMNp_N) 		4 PHE A 416
LEU A 292
PRO A 297
ARG A 415
 None
 1.32A 4yv5B-1t8wA:
undetectable		 4yv5B-1t8wA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2v ACTIN-RELATED
PROTEIN 2
ARP2/3 COMPLEX 16KDA
SUBUNIT

(Bos taurus) 		PF00022
(Actin)
PF04699
(P16-Arc) 		4 PHE G  11
LYS G   9
ASN B 226
ARG B 328
 None
 1.38A 4yv5B-1u2vG:
undetectable		 4yv5B-1u2vG:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v7v CHITOBIOSE
PHOSPHORYLASE

(Vibrio
proteolyticus) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 LEU A 669
ASN A 670
PRO A 671
ARG A 333
 None
 1.22A 4yv5B-1v7vA:
undetectable		 4yv5B-1v7vA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve3 HYPOTHETICAL PROTEIN
PH0226

(Pyrococcus
horikoshii) 		PF13649
(Methyltransf_25) 		4 LYS A 133
LEU A 132
ASN A 225
PRO A 226
 None
 1.41A 4yv5B-1ve3A:
undetectable		 4yv5B-1ve3A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vl4 PMBA-RELATED PROTEIN

(Thermotoga
maritima) 		PF01523
(PmbA_TldD) 		4 PHE A   3
LYS A   7
LEU A  10
PRO A  72
 None
 1.45A 4yv5B-1vl4A:
undetectable		 4yv5B-1vl4A:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y6l UBIQUITIN-CONJUGATIN
G ENZYME E2E2

(Homo sapiens) 		PF00179
(UQ_con) 		4 LYS A 101
LEU A 104
PRO A  18
ARG A   5
 None
 1.40A 4yv5B-1y6lA:
undetectable		 4yv5B-1y6lA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yem CONSERVED
HYPOTHETICAL PROTEIN
PFU-838710-001

(Pyrococcus
furiosus) 		PF01928
(CYTH) 		4 PHE A  14
LEU A 107
ASN A  22
PRO A  23
 None
 1.08A 4yv5B-1yemA:
undetectable		 4yv5B-1yemA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE

(Thermotoga
maritima) 		PF00294
(PfkB) 		4 LEU A  55
ASN A  58
PRO A  56
ARG A 105
 None
 1.43A 4yv5B-2afbA:
undetectable		 4yv5B-2afbA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e87 HYPOTHETICAL PROTEIN
PH1320

(Pyrococcus
horikoshii) 		PF06858
(NOG1) 		4 PHE A 304
LEU A 310
ASN A 311
PRO A 312
 None
 1.45A 4yv5B-2e87A:
undetectable		 4yv5B-2e87A:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5u VIRION PROTEIN UL25

(Human
alphaherpesvirus
1) 		PF01499
(Herpes_UL25) 		4 PHE A 464
LEU A 153
ASN A 152
PRO A 154
 None
 1.39A 4yv5B-2f5uA:
0.7		 4yv5B-2f5uA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i1j MOESIN

(Spodoptera
frugiperda) 		PF00373
(FERM_M)
PF00769
(ERM)
PF09379
(FERM_N)
PF09380
(FERM_C) 		4 PHE A  18
LEU A  76
ASN A  74
PRO A  75
 None
URE  A 577 (-4.2A)
URE  A 577 (-3.4A)
None
 1.09A 4yv5B-2i1jA:
undetectable		 4yv5B-2i1jA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mbr URIDINE
DIPHOSPHO-N-ACETYLEN
OLPYRUVYLGLUCOSAMINE
REDUCTASE

(Escherichia
coli) 		PF01565
(FAD_binding_4)
PF02873
(MurB_C) 		4 LYS A 217
LEU A 218
ASN A 226
PRO A 219
 EPU  A 402 (-3.6A)
EPU  A 402 ( 4.6A)
FAD  A 401 (-3.5A)
None
 1.37A 4yv5B-2mbrA:
undetectable		 4yv5B-2mbrA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mbr URIDINE
DIPHOSPHO-N-ACETYLEN
OLPYRUVYLGLUCOSAMINE
REDUCTASE

(Escherichia
coli) 		PF01565
(FAD_binding_4)
PF02873
(MurB_C) 		4 PHE A 318
LEU A 322
ASN A 233
PRO A 234
 None
None
EPU  A 402 (-2.9A)
None
 1.30A 4yv5B-2mbrA:
undetectable		 4yv5B-2mbrA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qxy RESPONSE REGULATOR

(Thermotoga
maritima) 		PF00072
(Response_reg) 		4 PHE A  17
LYS A  21
LEU A  24
ARG A  14
 None
 1.04A 4yv5B-2qxyA:
undetectable		 4yv5B-2qxyA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uzx HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF01403
(Sema)
PF01437
(PSI)
PF01833
(TIG) 		4 PHE B 590
LEU B 562
PRO B 563
ARG B 592
 None
 1.39A 4yv5B-2uzxB:
undetectable		 4yv5B-2uzxB:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xu0 ERYTHROCYTE MEMBRANE
PROTEIN 1

(Plasmodium
falciparum) 		PF05424
(Duffy_binding)
PF15447
(NTS) 		4 LEU A 210
ASN A 212
PRO A 211
ARG A 253
 None
None
GOL  A1491 (-4.8A)
None
 0.95A 4yv5B-2xu0A:
undetectable		 4yv5B-2xu0A:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y6p 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE

(Aquifex
aeolicus) 		PF02348
(CTP_transf_3) 		4 LYS A 174
LEU A 177
ASN A  91
ARG A   2
 None
 1.27A 4yv5B-2y6pA:
undetectable		 4yv5B-2y6pA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yk0 ERYTHROCYTE MEMBRANE
PROTEIN 1

(Plasmodium
falciparum) 		PF03011
(PFEMP)
PF05424
(Duffy_binding)
PF15447
(NTS) 		4 LEU A 210
ASN A 212
PRO A 211
ARG A 253
 None
 1.11A 4yv5B-2yk0A:
undetectable		 4yv5B-2yk0A:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2

(Saccharomyces
cerevisiae) 		PF04072
(LCM)
PF13418
(Kelch_4) 		4 PHE A 265
LEU A 256
ASN A 287
PRO A 258
 None
 1.38A 4yv5B-2zwaA:
undetectable		 4yv5B-2zwaA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aii GLUTAMYL-TRNA
SYNTHETASE

(Methanothermobacter
thermautotrophicus) 		PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C) 		4 PHE A 405
LEU A 448
PRO A 449
ARG A 438
 None
 1.30A 4yv5B-3aiiA:
undetectable		 4yv5B-3aiiA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayx MEMBRANE-BOUND
HYDROGENASE LARGE
SUBUNIT
MEMBRANE-BOUND
HYDROGENASE SMALL
SUBUNIT

(Hydrogenovibrio
marinus) 		PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		4 PHE A 174
ASN A 133
PRO A 134
ARG B  12
 None
 1.38A 4yv5B-3ayxA:
undetectable		 4yv5B-3ayxA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b97 ALPHA-ENOLASE

(Homo sapiens) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 PHE A 260
LEU A 162
ASN A 215
ARG A 252
 None
 1.16A 4yv5B-3b97A:
undetectable		 4yv5B-3b97A:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bzh UBIQUITIN-CONJUGATIN
G ENZYME E2 E1

(Homo sapiens) 		PF00179
(UQ_con) 		4 LYS A 147
LEU A 150
PRO A  64
ARG A  51
 None
 1.37A 4yv5B-3bzhA:
undetectable		 4yv5B-3bzhA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ck2 CONSERVED
UNCHARACTERIZED
PROTEIN (PREDICTED
PHOSPHOESTERASE
COG0622)

(Streptococcus
pneumoniae) 		PF12850
(Metallophos_2) 		4 PHE A  34
LEU A 125
ASN A 126
PRO A 127
 None
 1.41A 4yv5B-3ck2A:
undetectable		 4yv5B-3ck2A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cqc NUCLEAR PORE COMPLEX
PROTEIN NUP133

(Homo sapiens) 		no annotation 4 PHE B 964
LYS B 968
LEU B 971
ASN B 958
 None
 1.38A 4yv5B-3cqcB:
1.7		 4yv5B-3cqcB:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ejg NON-STRUCTURAL
PROTEIN 3

(Human
coronavirus
229E) 		PF01661
(Macro) 		4 PHE A 126
LEU A  45
PRO A 119
ARG A  93
 None
 1.36A 4yv5B-3ejgA:
undetectable		 4yv5B-3ejgA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ekm DIAMINOPIMELATE
EPIMERASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF01678
(DAP_epimerase) 		4 LEU A 209
ASN A 208
PRO A 210
ARG A  63
 None
 1.37A 4yv5B-3ekmA:
undetectable		 4yv5B-3ekmA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fbg PUTATIVE ARGINATE
LYASE

(Staphylococcus
haemolyticus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A 322
ASN A  43
PRO A  44
ARG A 182
 None
 1.24A 4yv5B-3fbgA:
undetectable		 4yv5B-3fbgA:
15.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g8g PHOSPHOLIPASE A2,
AMMODYTOXIN A

(Vipera
ammodytes) 		PF00068
(Phospholip_A2_1) 		4 LEU A  10
ASN A  16
PRO A  17
ARG A  63
 None
 0.68A 4yv5B-3g8gA:
20.7		 4yv5B-3g8gA:
60.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdc THIOREDOXIN FAMILY
PROTEIN

(Geobacter
metallireducens) 		PF00578
(AhpC-TSA) 		4 PHE A 104
LEU A 118
ASN A  51
PRO A  45
 None
 1.44A 4yv5B-3hdcA:
undetectable		 4yv5B-3hdcA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdo HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Geobacter
metallireducens) 		PF00155
(Aminotran_1_2) 		4 PHE A 131
LEU A 153
ASN A 157
ARG A 129
 None
 1.37A 4yv5B-3hdoA:
undetectable		 4yv5B-3hdoA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hv0 TRYPTOPHANYL-TRNA
SYNTHETASE

(Cryptosporidium
parvum) 		PF00579
(tRNA-synt_1b) 		4 PHE A 353
LEU A 364
PRO A 404
ARG A 582
 None
 1.30A 4yv5B-3hv0A:
undetectable		 4yv5B-3hv0A:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3js8 CHOLESTEROL OXIDASE

(Chromobacterium
sp. DS-1) 		PF01565
(FAD_binding_4)
PF09129
(Chol_subst-bind) 		4 LYS A 518
LEU A 521
PRO A 197
ARG A 505
 None
 1.26A 4yv5B-3js8A:
undetectable		 4yv5B-3js8A:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k96 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]

(Coxiella
burnetii) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		4 LEU A  54
ASN A  56
PRO A  55
ARG A 259
 None
 1.43A 4yv5B-3k96A:
undetectable		 4yv5B-3k96A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ka7 OXIDOREDUCTASE

(Methanosarcina
mazei) 		PF01593
(Amino_oxidase) 		4 LEU A  57
ASN A  59
PRO A  58
ARG A  38
 None
None
FAD  A 500 (-4.1A)
FAD  A 500 (-3.7A)
 1.29A 4yv5B-3ka7A:
undetectable		 4yv5B-3ka7A:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l9c 3-DEHYDROQUINATE
DEHYDRATASE

(Streptococcus
mutans) 		PF01487
(DHquinase_I) 		4 LEU A 127
ASN A 126
PRO A 124
ARG A  62
 None
 1.45A 4yv5B-3l9cA:
undetectable		 4yv5B-3l9cA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3luy PROBABLE CHORISMATE
MUTASE

(Bifidobacterium
adolescentis) 		PF00800
(PDT) 		4 PHE A  30
LEU A 192
ASN A 200
PRO A 195
 None
 1.30A 4yv5B-3luyA:
undetectable		 4yv5B-3luyA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lyr TRANSCRIPTION FACTOR
COE1

(Homo sapiens) 		PF16422
(COE1_DBD) 		4 PHE A 211
LEU A  62
PRO A  59
ARG A 209
 None
 1.36A 4yv5B-3lyrA:
undetectable		 4yv5B-3lyrA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mln TRANSCRIPTION FACTOR
COE1

(Mus musculus) 		PF16422
(COE1_DBD) 		4 PHE A 211
LEU A  62
PRO A  59
ARG A 209
 None
 1.45A 4yv5B-3mlnA:
undetectable		 4yv5B-3mlnA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3omx CG14216

(Drosophila
melanogaster) 		PF04722
(Ssu72) 		4 PHE A 180
LEU A 138
ASN A 139
ARG A 183
 None
 1.45A 4yv5B-3omxA:
undetectable		 4yv5B-3omxA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfr MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Actinobacillus
succinogenes) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 384
ASN A 382
PRO A 383
ARG A  39
 None
 1.26A 4yv5B-3pfrA:
undetectable		 4yv5B-3pfrA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6f HYPOTHETICAL
ACETYLTRANSFERASE

(Deinococcus
radiodurans) 		PF13673
(Acetyltransf_10) 		4 LEU A  66
ASN A  64
PRO A  76
ARG A 134
 LEU  A  66 ( 0.5A)
ASN  A  64 ( 0.6A)
PRO  A  76 ( 1.1A)
ARG  A 134 ( 0.6A)
 1.27A 4yv5B-3s6fA:
undetectable		 4yv5B-3s6fA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sn0 PUTATIVE
L-ALANINE-DL-GLUTAMA
TE EPIMERASE

(Paraburkholderia
xenovorans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 PHE A 183
LEU A 187
ASN A 221
PRO A 177
 None
 1.41A 4yv5B-3sn0A:
undetectable		 4yv5B-3sn0A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttl POLYAMINE TRANSPORT
PROTEIN

(Pseudomonas
aeruginosa) 		PF13416
(SBP_bac_8) 		4 LYS A 102
LEU A 103
ASN A 105
PRO A 104
 None
 1.22A 4yv5B-3ttlA:
undetectable		 4yv5B-3ttlA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vzb SPHINGOSINE KINASE 1

(Homo sapiens) 		PF00781
(DAGK_cat) 		4 LEU A 134
ASN A 114
PRO A 109
ARG A 144
 None
 1.44A 4yv5B-3vzbA:
undetectable		 4yv5B-3vzbA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wme ATP-BINDING
CASSETTE, SUB-FAMILY
B, MEMBER 1

(Cyanidioschyzon
merolae) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 PHE A 243
LEU A 388
PRO A 136
ARG A 181
 None
 1.19A 4yv5B-3wmeA:
undetectable		 4yv5B-3wmeA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zf8 MANNAN POLYMERASE
COMPLEXES SUBUNIT
MNN9

(Saccharomyces
cerevisiae) 		PF03452
(Anp1) 		4 PHE A 380
LEU A 382
ASN A 384
PRO A 383
 None
 1.43A 4yv5B-3zf8A:
undetectable		 4yv5B-3zf8A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4apl APICAL MEMBRANE
ANTIGEN 1

(Neospora
caninum) 		PF02430
(AMA-1) 		4 PHE A 250
LEU A 149
ASN A 147
PRO A 148
 None
 1.33A 4yv5B-4aplA:
undetectable		 4yv5B-4aplA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bmv SHORT-CHAIN
DEHYDROGENASE

(Sphingobium
yanoikuyae) 		PF00106
(adh_short) 		4 PHE A 127
LEU A 167
ASN A 168
ARG A 126
 None
 1.43A 4yv5B-4bmvA:
undetectable		 4yv5B-4bmvA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyk AMIDOHYDROLASE

(Pseudomonas
aeruginosa) 		PF01979
(Amidohydro_1) 		4 LEU A 329
ASN A 284
PRO A 281
ARG A 344
 None
 0.95A 4yv5B-4dykA:
undetectable		 4yv5B-4dykA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL

(Homo sapiens) 		PF00067
(p450) 		4 PHE A 239
LEU A 113
PRO A 115
ARG A  51
 None
 1.16A 4yv5B-4fdhA:
undetectable		 4yv5B-4fdhA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl0 LMO0810 PROTEIN

(Listeria
monocytogenes) 		PF13416
(SBP_bac_8) 		4 LYS A 110
LEU A 111
ASN A 113
PRO A 112
 None
 1.13A 4yv5B-4gl0A:
undetectable		 4yv5B-4gl0A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iig BETA-GLUCOSIDASE 1

(Aspergillus
aculeatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 LYS A 394
LEU A 395
ASN A 111
PRO A 107
 None
 1.42A 4yv5B-4iigA:
undetectable		 4yv5B-4iigA:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jb1 UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE

(Pseudomonas
aeruginosa) 		PF01565
(FAD_binding_4)
PF02873
(MurB_C) 		4 PHE A 328
LEU A 332
ASN A 243
PRO A 244
 None
None
NAP  A 402 (-2.8A)
None
 1.14A 4yv5B-4jb1A:
undetectable		 4yv5B-4jb1A:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k28 SHIKIMATE
DEHYDROGENASE FAMILY
PROTEIN

(Pseudomonas
putida) 		PF00899
(ThiF)
PF08501
(Shikimate_dh_N) 		4 PHE A 188
LEU A 207
ASN A 193
ARG A 127
 None
 1.42A 4yv5B-4k28A:
undetectable		 4yv5B-4k28A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4llf CAPSID PROTEIN

(Cucumber
necrosis virus) 		PF00729
(Viral_coat) 		4 PHE A 255
LYS A 148
ASN A 127
PRO A 128
 None
 1.18A 4yv5B-4llfA:
undetectable		 4yv5B-4llfA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE

(Thermococcus
kodakarensis) 		PF00562
(RNA_pol_Rpb2_6)
PF00623
(RNA_pol_Rpb1_2)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 LEU B 729
ASN B 915
PRO B 916
ARG A 516
 None
 1.41A 4yv5B-4qiwB:
undetectable		 4yv5B-4qiwB:
6.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qqs GLYCOSIDE HYDROLASE
FAMILY 43

(Halothermothrix
orenii) 		PF04616
(Glyco_hydro_43) 		4 PHE A 118
LEU A 100
ASN A 112
ARG A 120
 None
 1.26A 4yv5B-4qqsA:
undetectable		 4yv5B-4qqsA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8p E3 UBIQUITIN-PROTEIN
LIGASE RING2,
UBIQUITIN-CONJUGATIN
G ENZYME E2 D3

(Homo sapiens) 		PF00179
(UQ_con)
PF13923
(zf-C3HC4_2) 		4 LYS L 301
LEU L 304
PRO L 218
ARG L 205
 None
 1.42A 4yv5B-4r8pL:
undetectable		 4yv5B-4r8pL:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rm9 EZRIN

(Homo sapiens) 		PF00373
(FERM_M)
PF00769
(ERM)
PF09379
(FERM_N)
PF09380
(FERM_C) 		4 PHE A  18
LEU A  76
ASN A  74
PRO A  75
 None
 1.21A 4yv5B-4rm9A:
undetectable		 4yv5B-4rm9A:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rma EZRIN

(Homo sapiens) 		PF00373
(FERM_M)
PF09379
(FERM_N)
PF09380
(FERM_C) 		4 PHE A  18
LEU A  76
ASN A  74
PRO A  75
 None
 1.15A 4yv5B-4rmaA:
undetectable		 4yv5B-4rmaA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ru0 PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC
TRANSPORTER,
PERIPLASMIC
BRANCHED-CHAIN AMINO
ACID-BINDING PROTEIN

(Pseudomonas
protegens) 		PF13458
(Peripla_BP_6) 		4 PHE A 154
ASN A 147
PRO A 149
ARG A 238
 None
 1.36A 4yv5B-4ru0A:
undetectable		 4yv5B-4ru0A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u98 MALTOKINASE

(Mycolicibacterium
vanbaalenii) 		PF01636
(APH) 		4 LEU A 331
ASN A 159
PRO A 160
ARG A 342
 None
 1.21A 4yv5B-4u98A:
0.9		 4yv5B-4u98A:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ufc GH95

(Bacteroides
ovatus) 		PF14498
(Glyco_hyd_65N_2) 		4 LYS A 546
LEU A 547
ASN A 513
PRO A 548
 None
 1.15A 4yv5B-4ufcA:
undetectable		 4yv5B-4ufcA:
10.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wtb BASIC PHOSPHOLIPASE
A2 HOMOLOG
BOTHROPSTOXIN-1

(Bothrops
jararacussu) 		PF00068
(Phospholip_A2_1) 		6 PHE A   3
LYS A   7
LEU A  10
ASN A  16
PRO A  17
ARG A  63
 None
 0.59A 4yv5B-4wtbA:
23.9		 4yv5B-4wtbA:
94.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ye5 PEPTIDOGLYCAN
SYNTHETASE
PENICILLIN-BINDING
PROTEIN 3

(Bifidobacterium
adolescentis) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		4 LYS A 143
LEU A 144
ASN A  89
PRO A  90
 None
 1.19A 4yv5B-4ye5A:
undetectable		 4yv5B-4ye5A:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yiv APICAL MEMBRANE
ANTIGEN AMA1

(Toxoplasma
gondii) 		PF02430
(AMA-1) 		4 PHE A 256
LEU A 155
ASN A 153
PRO A 154
 None
 1.19A 4yv5B-4yivA:
undetectable		 4yv5B-4yivA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a6w AVR-PIK PROTEIN

(Magnaporthe
oryzae) 		no annotation 4 PHE C  57
LEU C  95
ASN C  94
ARG C  64
 None
 1.34A 4yv5B-5a6wC:
undetectable		 4yv5B-5a6wC:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5azb PROLIPOPROTEIN
DIACYLGLYCERYL
TRANSFERASE

(Escherichia
coli) 		PF01790
(LGT) 		4 LEU A 134
ASN A 215
PRO A 133
ARG A 122
 PGT  A 305 ( 4.7A)
None
None
None
 1.40A 4yv5B-5azbA:
undetectable		 4yv5B-5azbA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c5s UNCONVENTIONAL
MYOSIN-IXB

(Homo sapiens) 		PF00620
(RhoGAP) 		4 PHE A 246
LYS A 250
LEU A 253
ARG A 243
 None
 1.38A 4yv5B-5c5sA:
undetectable		 4yv5B-5c5sA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dl5 MEMBRANE PROTEIN

(Acinetobacter
baumannii) 		PF03573
(OprD) 		4 PHE A 224
LEU A 303
ASN A 305
PRO A 304
 None
 0.97A 4yv5B-5dl5A:
undetectable		 4yv5B-5dl5A:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ik2 ATP SYNTHASE GAMMA
CHAIN

(Caldalkalibacillus
thermarum) 		PF00231
(ATP-synt) 		4 PHE G 238
LYS G 234
LEU G 231
ARG G 241
 None
 1.01A 4yv5B-5ik2G:
1.1		 4yv5B-5ik2G:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jj7 ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE FICD
HOMOLOG

(Caenorhabditis
elegans) 		PF02661
(Fic) 		4 PHE A 264
LEU A 311
ASN A 419
ARG A 284
 None
 1.42A 4yv5B-5jj7A:
undetectable		 4yv5B-5jj7A:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzx UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE

(Mycobacterium
tuberculosis) 		PF01565
(FAD_binding_4)
PF02873
(MurB_C) 		4 PHE A 354
LEU A 358
ASN A 261
PRO A 262
 None
 1.32A 4yv5B-5jzxA:
undetectable		 4yv5B-5jzxA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m60 BETA-1,3-GLUCANASE

(Chaetomium
thermophilum) 		PF12708
(Pectate_lyase_3) 		4 PHE A 668
ASN A 563
PRO A 662
ARG A 613
 None
 1.12A 4yv5B-5m60A:
undetectable		 4yv5B-5m60A:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n2g DNA POLYMERASE

(Vaccinia virus) 		no annotation 4 PHE A 992
LEU A 983
ASN A 981
ARG A 995
 None
 1.08A 4yv5B-5n2gA:
undetectable		 4yv5B-5n2gA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5suo EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF12010
(DUF3502) 		4 LYS A 409
LEU A 412
ASN A 155
PRO A 287
 None
None
None
IOD  A 501 ( 4.3A)
 1.39A 4yv5B-5suoA:
undetectable		 4yv5B-5suoA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5trw PYRIDOXAL KINASE
PDXY

(Paraburkholderia
xenovorans) 		PF08543
(Phos_pyr_kin) 		4 LEU A 149
ASN A 145
PRO A 144
ARG A 133
 None
CL  A 405 (-3.4A)
None
SO4  A 403 (-3.7A)
 1.45A 4yv5B-5trwA:
undetectable		 4yv5B-5trwA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb DNA REPLICATION
LICENSING FACTOR
MCM6

(Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		4 PHE 6 712
ASN 6 683
PRO 6 684
ARG 6 794
 None
AGS  61101 (-1.5A)
None
None
 1.41A 4yv5B-5udb6:
undetectable		 4yv5B-5udb6:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uhp O-GLCNACASE
TIM-BARREL DOMAIN

(Homo sapiens) 		PF07555
(NAGidase) 		4 LYS A 308
LEU A  61
ASN A  91
ARG A 340
 None
 1.05A 4yv5B-5uhpA:
undetectable		 4yv5B-5uhpA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vf3 MAJOR CAPSID PROTEIN

(Escherichia
virus T4) 		PF07068
(Gp23) 		4 PHE A 125
LYS A 256
ASN A 482
PRO A 483
 None
 1.05A 4yv5B-5vf3A:
undetectable		 4yv5B-5vf3A:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbf UNCONVENTIONAL
MYOSIN-VIIB

(Homo sapiens) 		PF00373
(FERM_M)
PF00784
(MyTH4) 		4 PHE A1754
LEU A1747
PRO A1743
ARG A1758
 None
 1.38A 4yv5B-5xbfA:
undetectable		 4yv5B-5xbfA:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN

(Homo sapiens) 		PF00415
(RCC1)
PF13540
(RCC1_2) 		4 PHE A  77
LEU A 103
PRO A 161
ARG A  93
 None
 1.35A 4yv5B-5xgsA:
undetectable		 4yv5B-5xgsA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ce2 -

(-) 		no annotation 5 LYS A   7
LEU A  10
ASN A  17
PRO A  18
ARG A  72
 None
None
None
PE4  A 201 (-4.6A)
None
 0.34A 4yv5B-6ce2A:
24.3		 4yv5B-6ce2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cgm RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Bacillus
subtilis) 		no annotation 4 PHE A 171
LEU A 167
ASN A 158
PRO A 154
 None
 1.44A 4yv5B-6cgmA:
undetectable		 4yv5B-6cgmA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6enz ACIDIC AMINO ACID
DECARBOXYLASE GADL1

(Mus musculus) 		no annotation 4 PHE A 372
LEU A 120
ASN A 121
PRO A 122
 None
 1.26A 4yv5B-6enzA:
undetectable		 4yv5B-6enzA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fd7 -

(-) 		no annotation 4 LEU A 196
ASN A 166
PRO A 167
ARG A 226
 None
 1.44A 4yv5B-6fd7A:
undetectable		 4yv5B-6fd7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ghc -

(-) 		no annotation 4 PHE A  86
LYS A  99
LEU A  98
ASN A  41
 None
 1.32A 4yv5B-6ghcA:
undetectable		 4yv5B-6ghcA:
undetectable