SIMILAR PATTERNS OF AMINO ACIDS FOR 4YSH_B_GLYB401_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bou 4,5-DIOXYGENASE BETA
CHAIN

(Sphingomonas
paucimobilis) 		PF02900
(LigB) 		4 PHE B  81
LYS B  97
GLY B  98
ALA B 103
 None
 1.30A 4yshB-1bouB:
0.0		 4yshB-1bouB:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bsf THYMIDYLATE SYNTHASE
A

(Bacillus
subtilis) 		PF00303
(Thymidylat_synt) 		4 LYS A  79
GLY A 109
TYR A 108
ALA A 107
 None
 1.31A 4yshB-1bsfA:
undetectable		 4yshB-1bsfA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cf2 PROTEIN
(GLYCERALDEHYDE-3-PH
OSPHATE
DEHYDROGENASE)

(Methanothermus
fervidus) 		no annotation 4 GLY P  13
TYR P   9
ALA P  17
ARG P 272
 None
 1.22A 4yshB-1cf2P:
0.0		 4yshB-1cf2P:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e2y TRYPAREDOXIN
PEROXIDASE

(Crithidia
fasciculata) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		4 PHE A 131
GLY A 117
TYR A 116
ALA A 115
 None
 1.30A 4yshB-1e2yA:
0.6		 4yshB-1e2yA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE

(Streptomyces
antibioticus) 		PF00013
(KH_1)
PF01138
(RNase_PH)
PF03726
(PNPase) 		4 PHE A 529
LYS A 527
GLY A 525
ALA A 532
 None
 1.02A 4yshB-1e3hA:
0.0		 4yshB-1e3hA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hle HORSE LEUKOCYTE
ELASTASE INHIBITOR

(Equus caballus) 		PF00079
(Serpin) 		4 LYS A 181
GLY A 120
TYR A 119
ALA A 143
 None
 0.91A 4yshB-1hleA:
0.0		 4yshB-1hleA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ib8 CONSERVED PROTEIN
SP14.3

(Streptococcus
pneumoniae) 		PF02576
(DUF150)
PF17384
(DUF150_C) 		4 PHE A 121
LYS A 119
GLY A 110
ALA A 156
 None
 1.12A 4yshB-1ib8A:
undetectable		 4yshB-1ib8A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o75 47 KDA MEMBRANE
ANTIGEN

(Treponema
pallidum) 		PF14888
(PBP-Tp47_c)
PF14889
(PBP-Tp47_a) 		4 PHE A 405
LYS A 403
TYR A 335
ALA A 353
 None
 1.10A 4yshB-1o75A:
undetectable		 4yshB-1o75A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT

(Thauera
aromatica) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 PHE A 163
LYS A 341
TYR A 402
ALA A 329
 None
 1.32A 4yshB-1sb3A:
undetectable		 4yshB-1sb3A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t4n RIBONUCLEASE III

(Saccharomyces
cerevisiae) 		PF00035
(dsrm) 		4 LYS A 421
GLY A 424
TYR A 387
ALA A 428
 None
 1.19A 4yshB-1t4nA:
undetectable		 4yshB-1t4nA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8o BACTERIAL SIALIDASE

(Micromonospora
viridifaciens) 		PF00754
(F5_F8_type_C)
PF10633
(NPCBM_assoc)
PF13088
(BNR_2) 		4 PHE A 396
GLY A 382
TYR A 381
ALA A 375
 None
 1.03A 4yshB-1w8oA:
undetectable		 4yshB-1w8oA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xvt CROTONOBETAINYL-COA:
CARNITINE
COA-TRANSFERASE

(Escherichia
coli) 		PF02515
(CoA_transf_3) 		4 PHE A 147
GLY A 125
TYR A 201
ALA A 199
 None
COA  A 501 ( 4.7A)
None
None
 1.14A 4yshB-1xvtA:
4.1		 4yshB-1xvtA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cxy BAF250B SUBUNIT

(Homo sapiens) 		PF01388
(ARID) 		4 LYS A  55
GLY A  59
ALA A  61
ARG A 105
 None
 1.16A 4yshB-2cxyA:
undetectable		 4yshB-2cxyA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkk CYTOCHROME P450

(Streptomyces
coelicolor) 		PF00067
(p450) 		4 PHE A 355
GLY A 358
TYR A 349
ALA A 362
 None
HEM  A 430 ( 3.7A)
HEM  A 430 (-4.6A)
HEM  A 430 ( 3.7A)
 1.14A 4yshB-2dkkA:
undetectable		 4yshB-2dkkA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h1c TRAFFICKING PROTEIN
B

(Neisseria
gonorrhoeae) 		PF01850
(PIN) 		4 PHE A  78
GLY A 105
TYR A 106
ALA A 102
 None
 1.01A 4yshB-2h1cA:
undetectable		 4yshB-2h1cA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxv DIAMINOHYDROXYPHOSPH
ORIBOSYLAMINOPYRIMID
INE DEAMINASE/
5-AMINO-6-(5-PHOSPHO
RIBOSYLAMINO)URACIL
REDUCTASE

(Thermotoga
maritima) 		PF00383
(dCMP_cyt_deam_1)
PF01872
(RibD_C) 		4 PHE A 233
GLY A 227
TYR A 250
ALA A 248
 None
 0.96A 4yshB-2hxvA:
undetectable		 4yshB-2hxvA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inp PHENOL HYDROXYLASE
COMPONENT PHN

(Pseudomonas
stutzeri) 		PF02332
(Phenol_Hydrox)
PF04945
(YHS) 		4 LYS A 117
GLY A 114
TYR A 115
ALA A 111
 None
 1.15A 4yshB-2inpA:
undetectable		 4yshB-2inpA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k0r THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBD

(Neisseria
meningitidis) 		PF11412
(DsbC) 		4 PHE A  15
GLY A 101
TYR A  36
ALA A 103
 None
 1.21A 4yshB-2k0rA:
undetectable		 4yshB-2k0rA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n0m LIPID MODIFIED
AZURIN PROTEIN

(Neisseria
gonorrhoeae) 		PF00127
(Copper-bind) 		4 LYS A  64
GLY A  68
TYR A  74
ALA A  70
 None
 0.91A 4yshB-2n0mA:
undetectable		 4yshB-2n0mA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nwh CARBOHYDRATE KINASE

(Agrobacterium
fabrum) 		PF00294
(PfkB) 		4 PHE A 185
GLY A 258
TYR A 259
ALA A 272
 None
 1.04A 4yshB-2nwhA:
3.7		 4yshB-2nwhA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nwh CARBOHYDRATE KINASE

(Agrobacterium
fabrum) 		PF00294
(PfkB) 		4 PHE A 185
GLY A 276
TYR A 259
ALA A 272
 None
 1.25A 4yshB-2nwhA:
3.7		 4yshB-2nwhA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1b AMINOTRANSFERASE,
CLASS I

(Staphylococcus
aureus) 		PF00155
(Aminotran_1_2) 		4 PHE A 206
GLY A 204
TYR A 203
ALA A 202
 None
None
PLP  A 400 (-4.2A)
PLP  A 400 (-3.5A)
 1.20A 4yshB-2o1bA:
undetectable		 4yshB-2o1bA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oj4 REGULATOR OF
G-PROTEIN SIGNALING
3

(Homo sapiens) 		PF00615
(RGS) 		4 PHE A 117
GLY A  21
TYR A 123
ALA A   5
 None
 1.28A 4yshB-2oj4A:
undetectable		 4yshB-2oj4A:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qty POLY(ADP-RIBOSE)
GLYCOHYDROLASE ARH3

(Mus musculus) 		PF03747
(ADP_ribosyl_GH) 		4 PHE A 127
GLY A 134
TYR A 133
ALA A 256
 None
 1.15A 4yshB-2qtyA:
undetectable		 4yshB-2qtyA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wno TUMOR NECROSIS
FACTOR-INDUCIBLE
GENE 6 PROTEIN

(Homo sapiens) 		PF00431
(CUB) 		4 PHE A 229
GLY A 239
TYR A 155
ALA A 237
 None
 1.27A 4yshB-2wnoA:
undetectable		 4yshB-2wnoA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 PHE A 511
GLY A 695
TYR A 694
ALA A 693
 None
 1.07A 4yshB-2wtbA:
undetectable		 4yshB-2wtbA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yyy GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF01113
(DapB_N)
PF02800
(Gp_dh_C) 		4 GLY A  14
TYR A  10
ALA A  18
ARG A 279
 None
 1.29A 4yshB-2yyyA:
undetectable		 4yshB-2yyyA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zzw ABC TRANSPORTER,
SOLUTE-BINDING
PROTEIN

(Thermus
thermophilus) 		PF03480
(DctP) 		4 PHE A  81
GLY A 181
TYR A 101
ARG A 178
 None
None
LAC  A 401 (-4.4A)
LAC  A 401 (-2.9A)
 1.15A 4yshB-2zzwA:
undetectable		 4yshB-2zzwA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3amj ZINC PEPTIDASE
INACTIVE SUBUNIT

(Sphingomonas
sp. A1) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 LYS B 177
GLY B 176
TYR B 175
ALA B 174
 None
 1.22A 4yshB-3amjB:
undetectable		 4yshB-3amjB:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cg1 UPF0100 PROTEIN
PF0080

(Pyrococcus
furiosus) 		PF13531
(SBP_bac_11) 		4 PHE A 115
GLY A  93
TYR A 286
ALA A  40
 None
None
None
WO4  A 701 (-3.1A)
 1.11A 4yshB-3cg1A:
undetectable		 4yshB-3cg1A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE

(Mycobacterium
tuberculosis) 		PF00795
(CN_hydrolase)
PF02540
(NAD_synthase) 		4 PHE A 155
GLY A 139
TYR A 104
ALA A 137
 None
 1.29A 4yshB-3dlaA:
undetectable		 4yshB-3dlaA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dom RNA POLYMERASE II
TRANSCRIPTION FACTOR
B SUBUNIT 2
RNA POLYMERASE II
TRANSCRIPTION FACTOR
B SUBUNIT 5

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		no annotation
PF06331
(Tfb5) 		4 PHE A 491
LYS A 489
TYR A 459
ALA B   4
 None
 1.20A 4yshB-3domA:
undetectable		 4yshB-3domA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e61 PUTATIVE
TRANSCRIPTIONAL
REPRESSOR OF RIBOSE
OPERON

(Staphylococcus
saprophyticus) 		PF13377
(Peripla_BP_3) 		4 PHE A 158
LYS A 156
GLY A 161
ALA A 165
 None
 1.30A 4yshB-3e61A:
undetectable		 4yshB-3e61A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fn9 PUTATIVE
BETA-GALACTOSIDASE

(Bacteroides
fragilis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		4 PHE A  35
GLY A  81
TYR A  83
ALA A 148
 None
 1.18A 4yshB-3fn9A:
undetectable		 4yshB-3fn9A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g3t VACUOLAR TRANSPORTER
CHAPERONE 4

(Saccharomyces
cerevisiae) 		PF09359
(VTC) 		4 LYS A 458
GLY A 462
TYR A 250
ALA A 464
 None
 1.31A 4yshB-3g3tA:
undetectable		 4yshB-3g3tA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7r PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N) 		4 GLY A 109
TYR A  -4
ALA A 111
ARG A 164
 None
None
None
EDO  A 960 (-3.7A)
 1.16A 4yshB-3g7rA:
undetectable		 4yshB-3g7rA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyq RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE

(Streptomyces
cyaneus) 		PF00588
(SpoU_methylase)
PF04705
(TSNR_N) 		4 PHE A  97
LYS A  95
GLY A  55
TYR A  54
 None
 1.09A 4yshB-3gyqA:
undetectable		 4yshB-3gyqA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjp PEROXIREDOXIN,
BACTERIOFERRITIN
COMIGRATORY PROTEIN
HOMOLOG (BCP-4)

(Sulfolobus
solfataricus) 		PF00578
(AhpC-TSA) 		4 PHE A 122
GLY A 103
TYR A 102
ALA A 101
 None
 1.26A 4yshB-3hjpA:
undetectable		 4yshB-3hjpA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hol TBPB

(Actinobacillus
pleuropneumoniae) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		4 GLY A 126
TYR A 124
ALA A 266
ARG A 225
 None
 1.29A 4yshB-3holA:
undetectable		 4yshB-3holA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3

(Toxoplasma
gondii) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 LYS A 108
GLY A  88
TYR A  87
ALA A  86
 GOL  A 544 (-4.5A)
GOL  A 544 (-3.4A)
None
GOL  A   1 ( 4.7A)
 1.24A 4yshB-3hztA:
undetectable		 4yshB-3hztA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ig0 DNA GYRASE SUBUNIT B

(Mycobacterium
tuberculosis) 		PF00986
(DNA_gyraseB_C)
PF01751
(Toprim) 		4 LYS A 521
GLY A 510
TYR A 524
ALA A 508
 LYS  A 521 ( 0.0A)
GLY  A 510 ( 0.0A)
TYR  A 524 ( 1.3A)
ALA  A 508 ( 0.0A)
 1.00A 4yshB-3ig0A:
undetectable		 4yshB-3ig0A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jap EIF3C

(Saccharomyces
cerevisiae) 		PF00203
(Ribosomal_S19) 		4 PHE p 729
LYS p 684
GLY p 685
TYR p 725
 None
 1.16A 4yshB-3japp:
undetectable		 4yshB-3japp:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbh MYOSIN 2 HEAVY CHAIN
STRIATED MUSCLE

(Aphonopelma) 		PF00063
(Myosin_head)
PF01576
(Myosin_tail_1)
PF02736
(Myosin_N) 		4 PHE A 429
GLY A 228
TYR A 280
ALA A 230
 None
 1.27A 4yshB-3jbhA:
undetectable		 4yshB-3jbhA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kbb PHOSPHORYLATED
CARBOHYDRATES
PHOSPHATASE TM_1254

(Thermotoga
maritima) 		PF13419
(HAD_2) 		4 PHE A 163
GLY A 183
TYR A 182
ALA A 201
 PHE  A 163 ( 1.3A)
GLY  A 183 ( 0.0A)
TYR  A 182 ( 1.3A)
ALA  A 201 ( 0.0A)
 1.22A 4yshB-3kbbA:
undetectable		 4yshB-3kbbA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l0a PUTATIVE EXONUCLEASE

([Eubacterium]
rectale) 		PF12684
(DUF3799) 		4 PHE A  72
GLY A  58
TYR A  60
ALA A  93
 None
 1.18A 4yshB-3l0aA:
undetectable		 4yshB-3l0aA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mga ENTEROCHELIN
ESTERASE

(Salmonella
enterica) 		PF00756
(Esterase)
PF11806
(DUF3327) 		4 LYS A  25
GLY A  27
TYR A  29
ALA A  86
 None
 1.01A 4yshB-3mgaA:
undetectable		 4yshB-3mgaA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nk7 23S RRNA
METHYLTRANSFERASE

(Streptomyces
actuosus) 		PF00588
(SpoU_methylase)
PF04705
(TSNR_N) 		4 PHE A  97
LYS A  95
GLY A  55
TYR A  54
 None
 1.11A 4yshB-3nk7A:
undetectable		 4yshB-3nk7A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pbk FATTY ACYL-ADENYLATE
LIGASE

(Escherichia
coli) 		PF00501
(AMP-binding) 		4 PHE A 319
GLY A 280
TYR A 281
ALA A 276
 None
 1.17A 4yshB-3pbkA:
undetectable		 4yshB-3pbkA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3poc ALPHA-GLUCOSIDASE

(Blautia obeum) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 PHE A 207
GLY A 290
TYR A 293
ALA A 386
 None
 0.99A 4yshB-3pocA:
undetectable		 4yshB-3pocA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqs TRANSFERRIN-BINDING
PROTEIN

(Actinobacillus
pleuropneumoniae) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		4 GLY A 133
TYR A 131
ALA A 267
ARG A 232
 None
 1.30A 4yshB-3pqsA:
undetectable		 4yshB-3pqsA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqu TRANSFERRIN BINDING
PROTEIN B

(Actinobacillus
suis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		4 GLY A 164
TYR A 162
ALA A 315
ARG A 281
 None
 1.30A 4yshB-3pquA:
undetectable		 4yshB-3pquA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qki GLUCOSE-6-PHOSPHATE
ISOMERASE

(Plasmodium
falciparum) 		PF00342
(PGI) 		4 PHE A 505
LYS A 313
GLY A 311
ALA A 309
 None
 1.03A 4yshB-3qkiA:
undetectable		 4yshB-3qkiA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txy ISOCHORISMATASE
FAMILY PROTEIN
FAMILY

(Burkholderia
thailandensis) 		PF00857
(Isochorismatase) 		4 PHE A  54
GLY A  92
ALA A  39
ARG A  46
 None
 1.24A 4yshB-3txyA:
undetectable		 4yshB-3txyA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uaq LBPB B-LOBE

(Moraxella bovis) 		PF01298
(TbpB_B_D)
PF17484
(TbpB_A) 		4 GLY A 159
TYR A 157
ALA A 322
ARG A 281
 None
 1.25A 4yshB-3uaqA:
undetectable		 4yshB-3uaqA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wg6 CONJUGATED
POLYKETONE REDUCTASE
C1

(Candida
parapsilosis) 		PF00248
(Aldo_ket_red) 		4 PHE A  28
GLY A  61
TYR A  60
ALA A  57
 None
None
NDP  A3001 (-4.7A)
None
 1.25A 4yshB-3wg6A:
undetectable		 4yshB-3wg6A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aj9 CATALASE-3

(Neurospora
crassa) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 PHE A 338
GLY A 324
TYR A 323
ALA A 322
 1PE  A1721 ( 4.5A)
None
None
None
 1.09A 4yshB-4aj9A:
undetectable		 4yshB-4aj9A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwi PHYTOCHROME-LIKE
PROTEIN CPH2

(Synechocystis
sp.) 		PF00360
(PHY)
PF01590
(GAF) 		4 GLY A 354
TYR A 241
ALA A 243
ARG A 276
 None
 1.30A 4yshB-4bwiA:
undetectable		 4yshB-4bwiA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ds2 UBIQUITIN-CONJUGATIN
G ENZYME E2,
PUTATIVE

(Trypanosoma
cruzi) 		PF00179
(UQ_con) 		4 PHE A 128
LYS A  53
GLY A  61
TYR A  60
 None
 1.25A 4yshB-4ds2A:
undetectable		 4yshB-4ds2A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fb5 PROBABLE
OXIDOREDUCTASE
PROTEIN

(Rhizobium etli) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 PHE A 295
GLY A 269
TYR A 284
ALA A 286
 None
 1.23A 4yshB-4fb5A:
undetectable		 4yshB-4fb5A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g7v VOLTAGE-SENSOR
CONTAINING
PHOSPHATASE

(Ciona
intestinalis) 		PF00520
(Ion_trans) 		4 LYS S 175
GLY S 173
TYR S 172
ALA S 171
 None
 1.11A 4yshB-4g7vS:
undetectable		 4yshB-4g7vS:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hh8 BUTYROPHILIN
SUBFAMILY 1 MEMBER
A1

(Bos taurus) 		PF07686
(V-set)
PF08205
(C2-set_2) 		4 PHE A 174
GLY A 172
TYR A 144
ALA A  90
 None
 1.09A 4yshB-4hh8A:
undetectable		 4yshB-4hh8A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j9t DESIGNED UNNATURAL
AMINO ACID DEPENDENT
METALLOPROTEIN

(Micromonospora
viridifaciens) 		PF13088
(BNR_2) 		4 PHE A 396
GLY A 382
TYR A 381
ALA A 375
 None
 1.01A 4yshB-4j9tA:
undetectable		 4yshB-4j9tA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kn5 METHYLTHIOADENOSINE
NUCLEOSIDASE

(Weissella
paramesenteroides) 		PF01048
(PNP_UDP_1) 		4 PHE A 227
GLY A   4
TYR A   3
ALA A  70
 None
 1.03A 4yshB-4kn5A:
undetectable		 4yshB-4kn5A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mbg CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus) 		PF00432
(Prenyltrans) 		4 LYS B  68
GLY B  71
TYR B 119
ARG B 408
 None
 1.29A 4yshB-4mbgB:
undetectable		 4yshB-4mbgB:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mca GLYCEROL
DEHYDROGENASE

(Serratia
plymuthica) 		PF00465
(Fe-ADH) 		4 LYS A  26
GLY A  22
TYR A  24
ALA A  20
 None
 0.83A 4yshB-4mcaA:
undetectable		 4yshB-4mcaA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mdp BETA-GLUCOSIDASE

(Humicola grisea) 		PF00232
(Glyco_hydro_1) 		4 PHE A 469
GLY A  10
TYR A 424
ALA A 426
 None
 1.30A 4yshB-4mdpA:
undetectable		 4yshB-4mdpA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nf2 ORNITHINE
CARBAMOYLTRANSFERASE

(Bacillus
anthracis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 PHE A 247
GLY A 162
TYR A 250
ALA A 185
 None
 1.15A 4yshB-4nf2A:
undetectable		 4yshB-4nf2A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o4x TBPB

(Glaesserella
parasuis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		4 GLY A 131
TYR A 129
ALA A 271
ARG A 230
 None
 1.26A 4yshB-4o4xA:
undetectable		 4yshB-4o4xA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi6 CELLOBIOSE
DEHYDROGENASE

(Crassicarpon
hotsonii) 		PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C)
PF16010
(CDH-cyt) 		4 PHE A 403
LYS A 380
GLY A 381
ALA A 665
 None
 1.30A 4yshB-4qi6A:
11.4		 4yshB-4qi6A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qq1 TRANSFERRIN-BINDING
PROTEIN 2

(Neisseria
meningitidis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		4 GLY A 153
TYR A 151
ALA A 308
ARG A 269
 None
 1.29A 4yshB-4qq1A:
undetectable		 4yshB-4qq1A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tma DNA GYRASE SUBUNIT B

(Escherichia
coli) 		PF00986
(DNA_gyraseB_C)
PF01751
(Toprim) 		4 LYS B 487
GLY B 475
TYR B 490
ALA B 473
 None
 1.18A 4yshB-4tmaB:
undetectable		 4yshB-4tmaB:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wia PUTATIVE
FLAGELLA-RELATED
PROTEIN H

(Methanocaldococcus
jannaschii) 		PF06745
(ATPase) 		4 LYS A  18
GLY A  21
TYR A 211
ALA A 207
 GOL  A 306 (-2.5A)
None
None
None
 1.30A 4yshB-4wiaA:
undetectable		 4yshB-4wiaA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wj1 ANTIGEN MTB48,
MYCOBACTERIAL
PROTEIN

(Mycolicibacterium
smegmatis) 		no annotation 4 LYS A  80
GLY A  76
TYR A  78
ALA A  74
 None
 1.05A 4yshB-4wj1A:
undetectable		 4yshB-4wj1A:
24.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ysh GLYCINE OXIDASE

(Geobacillus
kaustophilus) 		PF01266
(DAO) 		4 PHE A 247
GLY A 251
TYR A 253
ALA A 266
 None
None
None
FAD  A 401 (-4.4A)
 0.57A 4yshB-4yshA:
62.9		 4yshB-4yshA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bza BETA-N-ACETYLHEXOSAM
INIDASE

(Thermotoga
neapolitana) 		PF00933
(Glyco_hydro_3) 		4 LYS A 152
GLY A 149
TYR A 150
ALA A 146
 None
 1.32A 4yshB-5bzaA:
undetectable		 4yshB-5bzaA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2v HYDRAZINE SYNTHASE
ALPHA SUBUNIT

(Candidatus
Kuenenia
stuttgartiensis) 		no annotation 4 PHE A 626
GLY A 563
TYR A 632
ALA A 488
 None
 1.00A 4yshB-5c2vA:
undetectable		 4yshB-5c2vA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cs4 ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF08326
(ACC_central) 		4 PHE A1133
TYR A1110
ALA A1295
ARG A1260
 None
 1.31A 4yshB-5cs4A:
undetectable		 4yshB-5cs4A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d62 AGGLUTININ

(Marasmius
oreades) 		PF14200
(RicinB_lectin_2) 		4 PHE A 242
GLY A 244
TYR A 293
ALA A 291
 None
 1.15A 4yshB-5d62A:
undetectable		 4yshB-5d62A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5en2 PRE-GLYCOPROTEIN
POLYPROTEIN GP
COMPLEX

(Argentinian
mammarenavirus) 		no annotation 4 PHE C 192
LYS C 193
GLY C 195
ALA C 151
 None
 0.97A 4yshB-5en2C:
undetectable		 4yshB-5en2C:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f4b NAD(P)H
DEHYDROGENASE
(QUINONE)

(Brucella
abortus) 		PF03358
(FMN_red) 		4 LYS A  88
TYR A   9
ALA A  77
ARG A  79
 None
None
CL  A 202 (-3.6A)
None
 1.13A 4yshB-5f4bA:
undetectable		 4yshB-5f4bA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmf RNA POLYMERASE II
TRANSCRIPTION FACTOR
B SUBUNIT 2, TFB2
RNA POLYMERASE II
TRANSCRIPTION FACTOR
B SUBUNIT 5, TFB5

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		no annotation
PF06331
(Tfb5) 		4 PHE W 491
LYS W 489
TYR W 459
ALA X   4
 None
 1.22A 4yshB-5fmfW:
undetectable		 4yshB-5fmfW:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ha8 ISOCHORISMATASE

(Microbacterium
hydrocarbonoxydans) 		PF00857
(Isochorismatase) 		4 PHE A 168
GLY A 123
TYR A 163
ALA A 121
 None
 1.25A 4yshB-5ha8A:
undetectable		 4yshB-5ha8A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i0p BETA-LACTAMASE
DOMAIN PROTEIN

(Burkholderia
ambifaria) 		PF00753
(Lactamase_B) 		4 PHE A 237
LYS A 324
GLY A 328
ALA A 332
 None
 1.00A 4yshB-5i0pA:
undetectable		 4yshB-5i0pA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5d INNER MEMBRANE
PROTEIN YEJM

(Salmonella
enterica) 		PF00884
(Sulfatase)
PF11893
(DUF3413) 		4 PHE A 583
GLY A 312
TYR A 246
ALA A 329
 None
 1.19A 4yshB-5i5dA:
undetectable		 4yshB-5i5dA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5igq E3 UBIQUITIN-PROTEIN
LIGASE RFWD2

(Homo sapiens) 		PF00400
(WD40) 		4 PHE A 595
LYS A 629
GLY A 628
TYR A 582
 None
 1.21A 4yshB-5igqA:
undetectable		 4yshB-5igqA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzn HELICASE
SEN1,HELICASE SEN1

(Saccharomyces
cerevisiae) 		PF13086
(AAA_11)
PF13087
(AAA_12) 		4 PHE A1584
GLY A1581
TYR A1606
ALA A1578
 None
 1.03A 4yshB-5mznA:
undetectable		 4yshB-5mznA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nbo GLYCOSYL HYDROLASE
FAMILY 16

(Bacteroides
ovatus) 		no annotation 4 PHE A 227
GLY A 142
TYR A 226
ALA A 140
 None
 1.25A 4yshB-5nboA:
undetectable		 4yshB-5nboA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ng6 CRISPR-ASSOCIATED
ENDONUCLEASE CPF1

(Francisella
tularensis) 		no annotation 4 PHE A1128
GLY A1140
TYR A1130
ALA A1138
 None
 1.17A 4yshB-5ng6A:
undetectable		 4yshB-5ng6A:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nhb XYLOSE ISOMERASE

(Piromyces sp.
E2) 		no annotation 4 PHE A  25
LYS A  13
TYR A  28
ALA A  30
 None
 1.15A 4yshB-5nhbA:
undetectable		 4yshB-5nhbA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oac MAJOR CAPSID PROTEIN

(unidentified
phage) 		no annotation 4 PHE A  50
LYS A  40
GLY A  38
ALA A  36
 None
 0.99A 4yshB-5oacA:
undetectable		 4yshB-5oacA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ui2 ORANGE
CAROTENOID-BINDING
PROTEIN

(Arthrospira
maxima) 		PF02136
(NTF2)
PF09150
(Carot_N) 		4 LYS A 167
TYR A 171
ALA A  99
ARG A  96
 None
 1.29A 4yshB-5ui2A:
undetectable		 4yshB-5ui2A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlq LOC100158544 PROTEIN

(Xenopus
tropicalis) 		PF03133
(TTL) 		4 PHE A 392
GLY A 505
TYR A 504
ALA A 523
 None
 1.08A 4yshB-5vlqA:
undetectable		 4yshB-5vlqA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wlh LBACAS13A H328A
(C2C2)

(Lachnospiraceae
bacterium
NK4A179) 		no annotation 4 PHE A1133
GLY A1136
TYR A 445
ALA A1140
 None
 1.29A 4yshB-5wlhA:
undetectable		 4yshB-5wlhA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yac TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5B

(Pyrococcus
abyssi) 		PF02475
(Met_10) 		4 LYS A 255
GLY A 278
TYR A 277
ALA A 323
 None
 0.91A 4yshB-5yacA:
undetectable		 4yshB-5yacA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yow GLYCOPROTEIN
POLYPROTEIN

(Heartland virus) 		no annotation 4 PHE A 328
LYS A  59
TYR A 202
ALA A 170
 None
FUC  A 504 (-2.9A)
None
None
 1.31A 4yshB-5yowA:
undetectable		 4yshB-5yowA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6apg DISD PROTEIN

(Sorangium
cellulosum) 		no annotation 4 PHE A 211
GLY A 104
TYR A 209
ALA A 106
 None
 1.27A 4yshB-6apgA:
undetectable		 4yshB-6apgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bsu XYLOGLUCAN
6-XYLOSYLTRANSFERASE
1

(Arabidopsis
thaliana) 		no annotation 4 LYS A 293
GLY A 291
TYR A 117
ALA A 288
 None
 0.94A 4yshB-6bsuA:
undetectable		 4yshB-6bsuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ehe OMPT PROTEIN

(Vibrio cholerae) 		no annotation 4 LYS A 123
GLY A 136
TYR A 137
ALA A 149
 None
C8E  A 404 (-4.5A)
None
C8E  A 404 (-3.6A)
 1.32A 4yshB-6eheA:
undetectable		 4yshB-6eheA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fd2 PUTATIVE APRAMYCIN
BIOSYNTHETIC
OXIDOREDUCTASE 4

(Streptoalloteichus
tenebrarius) 		no annotation 4 GLY B  29
TYR B 216
ALA B  27
ARG B 250
 None
D5E  B 501 ( 4.5A)
D5E  B 501 (-4.0A)
D5E  B 501 (-4.5A)
 1.22A 4yshB-6fd2B:
undetectable		 4yshB-6fd2B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fj4 ENDO-1,4-BETA-XYLANA
SE Y

(Ruminiclostridium
thermocellum) 		no annotation 4 PHE A1074
GLY A 949
TYR A 973
ALA A 972
 None
 1.25A 4yshB-6fj4A:
undetectable		 4yshB-6fj4A:
undetectable