SIMILAR PATTERNS OF AMINO ACIDS FOR 4YPM_A_BO2A801_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e3h | GUANOSINEPENTAPHOSPHATESYNTHETASE (Streptomycesantibioticus) |
PF00013(KH_1)PF01138(RNase_PH)PF03726(PNPase) | 5 | THR A 123LEU A 48GLY A 35SER A 144ALA A 37 | None | 1.13A | 4ypmA-1e3hA:3.8 | 4ypmA-1e3hA:19.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f20 | NITRIC-OXIDESYNTHASE (Rattusnorvegicus) |
PF00175(NAD_binding_1)PF00667(FAD_binding_1) | 5 | ALA A1254THR A1251GLY A1030PRO A1029SER A1258 | FAD A1501 ( 3.7A)NAP A1502 ( 3.9A)NoneNoneNone | 1.18A | 4ypmA-1f20A:undetectable | 4ypmA-1f20A:24.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g5i | MITOCHONDRIAL DNAPOLYMERASE ACCESSORYSUBUNIT (Mus musculus) |
PF03129(HGTP_anticodon) | 5 | THR A 418LEU A 416GLY A 390PRO A 389ALA A 358 | None | 1.18A | 4ypmA-1g5iA:undetectable | 4ypmA-1g5iA:22.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j2r | HYPOTHETICALISOCHORISMATASEFAMILY PROTEIN YECD (Escherichiacoli) |
PF00857(Isochorismatase) | 5 | ALA A 150THR A 149LEU A 137PRO A 184ALA A 187 | None | 1.22A | 4ypmA-1j2rA:undetectable | 4ypmA-1j2rA:22.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nba | N-CARBAMOYLSARCOSINEAMIDOHYDROLASE (Arthrobactersp.) |
PF00857(Isochorismatase) | 5 | ALA A 185LEU A 167PRO A 151SER A 148ALA A 149 | None | 1.18A | 4ypmA-1nbaA:undetectable | 4ypmA-1nbaA:25.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1odi | PURINE NUCLEOSIDEPHOSPHORYLASE (Thermusthermophilus) |
PF01048(PNP_UDP_1) | 5 | THR A 90GLY A 66PRO A 68SER A 69ALA A 70 | SO4 A1236 ( 3.0A)NoneNoneNoneNone | 1.06A | 4ypmA-1odiA:undetectable | 4ypmA-1odiA:24.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qo8 | FLAVOCYTOCHROME C3FUMARATE REDUCTASE (Shewanellafrigidimarina) |
PF00890(FAD_binding_2)PF14537(Cytochrom_c3_2) | 5 | THR A 255LEU A 256GLY A 158SER A 156ALA A 129 | NoneNoneFAD A 605 (-3.3A)NoneNone | 1.20A | 4ypmA-1qo8A:undetectable | 4ypmA-1qo8A:20.50 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1rr9 | ATP-DEPENDENTPROTEASE LA (Escherichiacoli) |
PF05362(Lon_C) | 8 | LEU A 611MET A 634THR A 673LYS A 675GLY A 677PRO A 678ALA A 680LYS A 722 | None | 0.77A | 4ypmA-1rr9A:29.4 | 4ypmA-1rr9A:38.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1szn | ALPHA-GALACTOSIDASE (Trichodermareesei) |
PF16499(Melibiase_2) | 5 | ALA A 280LEU A 307THR A 405GLY A 344PRO A 345 | None | 1.11A | 4ypmA-1sznA:undetectable | 4ypmA-1sznA:20.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1thm | THERMITASE (Thermoactinomycesvulgaris) |
PF00082(Peptidase_S8) | 5 | ALA A 93THR A 92GLY A 31SER A 240ALA A 239 | None | 1.15A | 4ypmA-1thmA:undetectable | 4ypmA-1thmA:23.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uek | 4-(CYTIDINE5'-DIPHOSPHO)-2C-METHYL-D-ERYTHRITOLKINASE (Thermusthermophilus) |
PF00288(GHMP_kinases_N)PF08544(GHMP_kinases_C) | 5 | ALA A 7LEU A 35GLY A 94SER A 96ALA A 5 | None | 1.17A | 4ypmA-1uekA:undetectable | 4ypmA-1uekA:24.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1whs | SERINECARBOXYPEPTIDASE II (Triticumaestivum) |
PF00450(Peptidase_S10) | 5 | ALA A 229THR A 226LEU A 206THR A 188GLY A 196 | None | 1.20A | 4ypmA-1whsA:undetectable | 4ypmA-1whsA:19.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xhk | PUTATIVE PROTEASE LAHOMOLOG (Methanocaldococcusjannaschii) |
PF05362(Lon_C) | 5 | ALA A 466GLY A 548SER A 550ALA A 551LYS A 593 | None | 0.73A | 4ypmA-1xhkA:21.7 | 4ypmA-1xhkA:26.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xp8 | RECA PROTEIN (Deinococcusradiodurans) |
PF00154(RecA) | 5 | THR A 259LEU A 87THR A 74GLY A 78PRO A 79 | None | 0.93A | 4ypmA-1xp8A:undetectable | 4ypmA-1xp8A:22.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zk7 | MERCURIC REDUCTASE (Pseudomonasaeruginosa) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | ALA A 239THR A 237THR A 253LEU A 251THR A 203 | None | 1.03A | 4ypmA-1zk7A:undetectable | 4ypmA-1zk7A:24.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ado | MEDIATOR OF DNADAMAGE CHECKPOINTPROTEIN 1 (Homo sapiens) |
PF16770(RTT107_BRCT_5) | 5 | THR A1928LEU A1926THR A1934GLY A1918ALA A1923 | None | 1.05A | 4ypmA-2adoA:undetectable | 4ypmA-2adoA:23.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cw5 | BACTERIALFLUORINATING ENZYMEHOMOLOG (Thermusthermophilus) |
PF01887(SAM_adeno_trans) | 5 | ALA A 81THR A 87LEU A 154PRO A 91ALA A 79 | None | 0.89A | 4ypmA-2cw5A:undetectable | 4ypmA-2cw5A:24.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eg3 | PROBABLE THIOSULFATESULFURTRANSFERASE (Thermusthermophilus) |
PF00581(Rhodanese) | 5 | THR A 124LEU A 84GLY A 194SER A 197ALA A 198 | None | 1.05A | 4ypmA-2eg3A:undetectable | 4ypmA-2eg3A:25.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2erq | VASCULARAPOPTOSIS-INDUCINGPROTEIN 1 (Crotalus atrox) |
PF00200(Disintegrin)PF01421(Reprolysin)PF08516(ADAM_CR) | 5 | ALA A 264THR A 267GLY A 298PRO A 299ALA A 301 | None | 1.22A | 4ypmA-2erqA:1.9 | 4ypmA-2erqA:21.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2igt | SAM DEPENDENTMETHYLTRANSFERASE (Agrobacteriumfabrum) |
PF10672(Methyltrans_SAM) | 5 | LEU A 248THR A 269PRO A 243SER A 242ALA A 245 | None | 1.16A | 4ypmA-2igtA:undetectable | 4ypmA-2igtA:23.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2irw | CORTICOSTEROID11-BETA-DEHYDROGENASE ISOZYME 1 (Homo sapiens) |
PF00106(adh_short) | 5 | ALA A 154THR A 151LEU A 116GLY A 112ALA A 106 | None | 1.21A | 4ypmA-2irwA:2.2 | 4ypmA-2irwA:22.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ixs | SDAI RESTRICTIONENDONUCLEASE (Streptomycesdiastaticus) |
PF06616(BsuBI_PstI_RE) | 5 | THR A 88THR A 38LEU A 42GLY A 96ALA A 122 | None | 1.05A | 4ypmA-2ixsA:undetectable | 4ypmA-2ixsA:22.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jbw | 2,6-DIHYDROXY-PSEUDO-OXYNICOTINEHYDROLASE (Paenarthrobacternicotinovorans) |
PF06500(DUF1100) | 5 | ALA A 167THR A 168GLY A 136PRO A 137ALA A 205 | None | 1.09A | 4ypmA-2jbwA:undetectable | 4ypmA-2jbwA:23.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p1f | URIDINE5'-MONOPHOSPHATESYNTHASE (Homo sapiens) |
PF00215(OMPdecase) | 5 | ALA A 113LEU A 109THR A 93GLY A 85PRO A 86 | None | 1.20A | 4ypmA-2p1fA:undetectable | 4ypmA-2p1fA:22.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qcm | URIDINE5'-MONOPHOSPHATESYNTHASE (UMPSYNTHASE) (Homo sapiens) |
PF00215(OMPdecase) | 5 | ALA A 302LEU A 298THR A 282GLY A 274PRO A 275 | None | 1.21A | 4ypmA-2qcmA:undetectable | 4ypmA-2qcmA:23.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qne | PUTATIVEMETHYLTRANSFERASE (Desulfitobacteriumhafniense) |
PF06253(MTTB) | 5 | ALA A 274THR A 272LEU A 283GLY A 236PRO A 237 | NoneEDO A 478 (-3.0A)NoneNoneNone | 1.22A | 4ypmA-2qneA:undetectable | 4ypmA-2qneA:22.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v7b | BENZOATE-COENZYME ALIGASE (Paraburkholderiaxenovorans) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 5 | ALA A 389THR A 335THR A 201GLY A 385PRO A 386 | None | 1.20A | 4ypmA-2v7bA:undetectable | 4ypmA-2v7bA:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v7b | BENZOATE-COENZYME ALIGASE (Paraburkholderiaxenovorans) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 5 | THR A 335THR A 201THR A 402GLY A 385PRO A 386 | None | 1.19A | 4ypmA-2v7bA:undetectable | 4ypmA-2v7bA:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vjw | GAF FAMILY PROTEIN (Mycolicibacteriumsmegmatis) |
PF01590(GAF) | 5 | ALA A 250THR A 253THR A 248GLY A 316ALA A 341 | None | 1.17A | 4ypmA-2vjwA:undetectable | 4ypmA-2vjwA:21.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w37 | ORNITHINECARBAMOYLTRANSFERASE, CATABOLIC (Lactobacillushilgardii) |
PF00185(OTCace)PF02729(OTCace_N) | 5 | THR A 334LEU A 335PRO A 80SER A 73ALA A 78 | None | 1.22A | 4ypmA-2w37A:undetectable | 4ypmA-2w37A:21.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2woc | ADP-RIBOSYL-[DINITROGEN REDUCTASE]GLYCOHYDROLASE (Rhodospirillumrubrum) |
PF03747(ADP_ribosyl_GH) | 5 | ALA A 166THR A 169LEU A 170GLY A 125ALA A 128 | None | 1.18A | 4ypmA-2wocA:undetectable | 4ypmA-2wocA:21.43 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2x36 | LON PROTEASEHOMOLOG,MITOCHONDRIAL (Homo sapiens) |
PF05362(Lon_C) | 7 | ALA A 769LEU A 778GLY A 853PRO A 854SER A 855ALA A 856LYS A 898 | None | 0.79A | 4ypmA-2x36A:24.6 | 4ypmA-2x36A:30.77 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2x36 | LON PROTEASEHOMOLOG,MITOCHONDRIAL (Homo sapiens) |
PF05362(Lon_C) | 5 | ALA A 769THR A 771PRO A 854SER A 855LYS A 898 | None | 0.75A | 4ypmA-2x36A:24.6 | 4ypmA-2x36A:30.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xdv | MYC-INDUCED NUCLEARANTIGEN (Homo sapiens) |
PF08007(Cupin_4) | 5 | ALA A 72THR A 75PRO A 30SER A 31ALA A 32 | None | 1.21A | 4ypmA-2xdvA:undetectable | 4ypmA-2xdvA:21.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xf8 | D-ERYTHROSE-4-PHOSPHATE DEHYDROGENASE (Escherichiacoli) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 5 | ALA A 227THR A 174THR A 208THR A 151GLY A 170 | NoneSO4 A 500 ( 4.8A)SO4 A 500 (-3.6A)NoneNone | 1.15A | 4ypmA-2xf8A:undetectable | 4ypmA-2xf8A:24.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zqe | MUTS2 PROTEIN (Thermusthermophilus) |
PF01713(Smr) | 5 | LEU A 38GLY A 69PRO A 68ALA A 66LYS A 41 | None | 1.03A | 4ypmA-2zqeA:undetectable | 4ypmA-2zqeA:17.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3acz | METHIONINEGAMMA-LYASE (Entamoebahistolytica) |
PF01053(Cys_Met_Meta_PP) | 5 | THR A 306MET A 300THR A 182GLY A 302ALA A 296 | NoneNoneLLP A 205 ( 3.6A)NoneNone | 1.22A | 4ypmA-3aczA:undetectable | 4ypmA-3aczA:24.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bbj | PUTATIVETHIOESTERASE II (Thermobifidafusca) |
PF13622(4HBT_3) | 5 | ALA A 68LEU A 40GLY A 71PRO A 72ALA A 73 | None | 1.10A | 4ypmA-3bbjA:undetectable | 4ypmA-3bbjA:25.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gwe | 3-OXOACYL-(ACYL-CARRIER-PROTEIN)SYNTHASE III (Burkholderiapseudomallei) |
PF08541(ACP_syn_III_C)PF08545(ACP_syn_III) | 5 | ALA A 148THR A 150THR A 88LEU A 86ALA A 172 | None | 0.90A | 4ypmA-3gweA:undetectable | 4ypmA-3gweA:23.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3led | 3-OXOACYL-ACYLCARRIER PROTEINSYNTHASE III (Rhodopseudomonaspalustris) |
PF08541(ACP_syn_III_C)PF08545(ACP_syn_III) | 5 | ALA A 208THR A 206THR A 9GLY A 162ALA A 166 | None | 0.99A | 4ypmA-3ledA:undetectable | 4ypmA-3ledA:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lg5 | EPI-ISOZIZAENESYNTHASE (Streptomycescoelicolor) |
no annotation | 5 | ALA A 140THR A 137GLY A 129PRO A 128ALA A 124 | None | 1.13A | 4ypmA-3lg5A:undetectable | 4ypmA-3lg5A:22.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m6a | ATP-DEPENDENTPROTEASE LA 1 (Bacillussubtilis) |
PF00004(AAA)PF05362(Lon_C) | 6 | ALA A 600LEU A 609GLY A 675PRO A 676ALA A 678LYS A 720 | None | 0.82A | 4ypmA-3m6aA:27.3 | 4ypmA-3m6aA:27.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m6a | ATP-DEPENDENTPROTEASE LA 1 (Bacillussubtilis) |
PF00004(AAA)PF05362(Lon_C) | 6 | ALA A 600THR A 602GLY A 675PRO A 676ALA A 678LYS A 720 | None | 1.01A | 4ypmA-3m6aA:27.3 | 4ypmA-3m6aA:27.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m6a | ATP-DEPENDENTPROTEASE LA 1 (Bacillussubtilis) |
PF00004(AAA)PF05362(Lon_C) | 6 | ALA A 600THR A 602MET A 632GLY A 675PRO A 676ALA A 678 | None | 1.19A | 4ypmA-3m6aA:27.3 | 4ypmA-3m6aA:27.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m6a | ATP-DEPENDENTPROTEASE LA 1 (Bacillussubtilis) |
PF00004(AAA)PF05362(Lon_C) | 5 | THR A 603LEU A 609GLY A 675PRO A 676ALA A 678 | None | 1.17A | 4ypmA-3m6aA:27.3 | 4ypmA-3m6aA:27.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nav | TRYPTOPHAN SYNTHASEALPHA CHAIN (Vibrio cholerae) |
PF00290(Trp_syntA) | 5 | ALA A 158THR A 162LEU A 163THR A 174PRO A 192 | None | 1.21A | 4ypmA-3navA:undetectable | 4ypmA-3navA:23.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nav | TRYPTOPHAN SYNTHASEALPHA CHAIN (Vibrio cholerae) |
PF00290(Trp_syntA) | 5 | ALA A 208THR A 174LEU A 176GLY A 227ALA A 223 | None | 0.92A | 4ypmA-3navA:undetectable | 4ypmA-3navA:23.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nd0 | SLL0855 PROTEIN (Synechocystissp. PCC 6803) |
PF00654(Voltage_CLC) | 5 | ALA A 141LEU A 135THR A 147GLY A 102ALA A 344 | None | 1.07A | 4ypmA-3nd0A:undetectable | 4ypmA-3nd0A:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nyq | MALONYL-COA LIGASE (Streptomycescoelicolor) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 5 | THR A 293THR A 366GLY A 340PRO A 341ALA A 159 | None | 1.11A | 4ypmA-3nyqA:undetectable | 4ypmA-3nyqA:20.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o03 | DEHYDROGENASE WITHDIFFERENTSPECIFICITIES (Streptococcussuis) |
PF13561(adh_short_C2) | 5 | ALA A 243LEU A 12SER A 247ALA A 246LYS A 144 | None | 1.17A | 4ypmA-3o03A:2.3 | 4ypmA-3o03A:21.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3org | CMCLC (Cyanidioschyzonmerolae) |
PF00654(Voltage_CLC) | 5 | ALA A 290LEU A 287GLY A 257SER A 254ALA A 253 | None | 1.18A | 4ypmA-3orgA:undetectable | 4ypmA-3orgA:20.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3px2 | N-METHYLTRANSFERASE (Streptomycesfradiae) |
PF13649(Methyltransf_25) | 6 | ALA A 113THR A 115LEU A 54PRO A 49SER A 48ALA A 51 | None | 1.48A | 4ypmA-3px2A:undetectable | 4ypmA-3px2A:24.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qpb | URIDINEPHOSPHORYLASE (Streptococcuspyogenes) |
PF01048(PNP_UDP_1) | 5 | THR A 97GLY A 73PRO A 75SER A 76ALA A 77 | R1P A1254 (-3.0A)NoneNoneNoneNone | 1.03A | 4ypmA-3qpbA:undetectable | 4ypmA-3qpbA:21.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qsz | STAR-RELATED LIPIDTRANSFER PROTEIN (Xanthomonascitri) |
PF01852(START) | 5 | ALA A 181THR A 184GLY A 173PRO A 172ALA A 170 | None | 1.00A | 4ypmA-3qszA:undetectable | 4ypmA-3qszA:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wad | GLYCOSYLTRANSFERASE (Streptomyceshalstedii) |
PF06722(DUF1205) | 5 | THR A 283THR A 325GLY A 231PRO A 232ALA A 233 | None | 1.19A | 4ypmA-3wadA:undetectable | 4ypmA-3wadA:22.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wo0 | ALANINE-ANTICAPSINLIGASE BACD (Bacillussubtilis) |
PF13535(ATP-grasp_4) | 5 | ALA A 327THR A 308LEU A 303PRO A 114ALA A 116 | None | 1.10A | 4ypmA-3wo0A:undetectable | 4ypmA-3wo0A:19.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a0s | OCTENOYL-COAREDUCTASE/CARBOXYLASE (Streptomycescinnabarigriseus) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | ALA A 444THR A 445GLY A 231SER A 230ALA A 260 | NoneNoneNAP A1447 (-3.3A)NAP A1447 (-3.6A)None | 1.16A | 4ypmA-4a0sA:undetectable | 4ypmA-4a0sA:22.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a0s | OCTENOYL-COAREDUCTASE/CARBOXYLASE (Streptomycescinnabarigriseus) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | ALA A 444THR A 445GLY A 407SER A 230ALA A 260 | NoneNoneNoneNAP A1447 (-3.6A)None | 1.09A | 4ypmA-4a0sA:undetectable | 4ypmA-4a0sA:22.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cr2 | 26S PROTEASEREGULATORY SUBUNIT 4HOMOLOG (Saccharomycescerevisiae) |
PF00004(AAA) | 5 | ALA I 242THR I 240LEU I 202LYS I 323ALA I 275 | None | 1.22A | 4ypmA-4cr2I:2.9 | 4ypmA-4cr2I:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4czp | EXTRALONG MANGANESEPEROXIDASE (Gelatoporiasubvermispora) |
PF00141(peroxidase)PF11895(Peroxidase_ext) | 5 | LYS A 54GLY A 56PRO A 57SER A 58ALA A 59 | None | 0.99A | 4ypmA-4czpA:undetectable | 4ypmA-4czpA:21.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hmw | PYRIDOXAMINE5'-PHOSPHATE OXIDASE (Burkholderialata) |
PF01243(Putative_PNPOx)PF10590(PNP_phzG_C) | 5 | ALA A 95THR A 53LEU A 51THR A 79PRO A 179 | NoneNoneNoneFMN A 301 (-3.7A)None | 1.18A | 4ypmA-4hmwA:undetectable | 4ypmA-4hmwA:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4idm | DELTA-1-PYRROLINE-5-CARBOXYLATEDEHYDROGENASE (Mycobacteriumtuberculosis) |
PF00171(Aldedh) | 5 | ALA A 471THR A 470LEU A 445GLY A 458ALA A 478 | None | 1.13A | 4ypmA-4idmA:2.8 | 4ypmA-4idmA:22.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4itx | CYSTATHIONINEBETA-LYASE METC (Escherichiacoli) |
PF01053(Cys_Met_Meta_PP) | 5 | ALA A 249THR A 252LEU A 67THR A 222GLY A 60 | None | 1.21A | 4ypmA-4itxA:undetectable | 4ypmA-4itxA:21.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jjj | CELLULOSE1,4-BETA-CELLOBIOSIDASE (Thermobifidafusca) |
PF02011(Glyco_hydro_48) | 6 | ALA A 503THR A 502LEU A 532THR A 543ALA A 627LYS A 507 | None | 1.37A | 4ypmA-4jjjA:undetectable | 4ypmA-4jjjA:18.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ldp | NDP-FOROSAMYLTRANSFERASE (Saccharopolysporaspinosa) |
PF06722(DUF1205) | 5 | THR A 294THR A 336GLY A 231PRO A 232ALA A 233 | None | 1.23A | 4ypmA-4ldpA:undetectable | 4ypmA-4ldpA:22.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lhb | MOLYBDOPTERINADENYLYLTRANSFERASE (Pyrococcusfuriosus) |
PF00994(MoCF_biosynth) | 5 | ALA A 125THR A 123LEU A 142THR A 151ALA A 127 | None | 1.19A | 4ypmA-4lhbA:undetectable | 4ypmA-4lhbA:22.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m8r | HYPOTHETICAL PROTEIN (Bacteroidescaccae) |
PF16023(DUF4784) | 5 | ALA A 229LEU A 240GLY A 283PRO A 282ALA A 219 | NoneNoneNoneEDO A 506 (-4.4A)None | 1.06A | 4ypmA-4m8rA:undetectable | 4ypmA-4m8rA:22.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oqy | (S)-IMINE REDUCTASE (Streptomycessp. GF3546) |
PF03446(NAD_binding_2) | 5 | ALA A 90LEU A 149THR A 133GLY A 137PRO A 138 | None | 1.20A | 4ypmA-4oqyA:undetectable | 4ypmA-4oqyA:24.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rh0 | SPORE PHOTOPRODUCTLYASE (Geobacillusthermodenitrificans) |
no annotation | 5 | ALA A 140THR A 141PRO A 78SER A 79ALA A 80 | NoneSO4 A 403 (-3.0A)NoneNoneNone | 1.21A | 4ypmA-4rh0A:undetectable | 4ypmA-4rh0A:24.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wpg | DTDP-4-DEHYDRORHAMNOSE REDUCTASE (Streptococcuspyogenes) |
PF04321(RmlD_sub_bind) | 5 | ALA A 59THR A 61THR A 150GLY A 134SER A 82 | None | 1.19A | 4ypmA-4wpgA:undetectable | 4ypmA-4wpgA:19.50 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ypl | LON PROTEASE (Meiothermustaiwanensis) |
PF00004(AAA)PF05362(Lon_C) | 12 | ALA A 601THR A 603THR A 608LEU A 610MET A 633THR A 672LYS A 674GLY A 676PRO A 677SER A 678ALA A 679LYS A 721 | 4KZ A 801 (-3.3A)4KZ A 801 ( 4.5A)None4KZ A 801 (-4.2A)4KZ A 801 (-3.6A)NoneNone4KZ A 801 (-3.3A)4KZ A 801 (-4.3A)4KZ A 801 (-1.4A)4KZ A 801 (-3.5A)4KZ A 801 (-3.4A) | 0.57A | 4ypmA-4yplA:34.6 | 4ypmA-4yplA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z9x | GLUCONATE5-DEHYDROGENASE (Streptococcuspyogenes) |
PF13561(adh_short_C2) | 5 | ALA A 238LEU A 7SER A 242ALA A 241LYS A 139 | None | 1.13A | 4ypmA-4z9xA:2.7 | 4ypmA-4z9xA:24.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a4j | FORMATE--TETRAHYDROFOLATE LIGASE (Tepidanaerobacteracetatoxydans) |
PF01268(FTHFS) | 5 | ALA A 267THR A 265LEU A 95MET A 121PRO A 120 | None | 0.92A | 4ypmA-5a4jA:undetectable | 4ypmA-5a4jA:22.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b5u | L-ASPARAGINASE (Pyrococcusfuriosus) |
PF00710(Asparaginase)no annotation | 5 | ALA B 294THR B 295GLY A 149SER A 90ALA A 87 | None | 1.11A | 4ypmA-5b5uB:undetectable | 4ypmA-5b5uB:23.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cu1 | DMSP LYASE (Ruegeriapomeroyi) |
PF16867(DMSP_lyase) | 5 | ALA A 113LEU A 188GLY A 105PRO A 106ALA A 108 | None | 1.22A | 4ypmA-5cu1A:undetectable | 4ypmA-5cu1A:20.72 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5e7s | LON PROTEASE (Meiothermustaiwanensis) |
PF05362(Lon_C) | 9 | LEU A 610MET A 633THR A 672LYS A 674GLY A 676PRO A 677SER A 678ALA A 679LYS A 721 | None | 0.71A | 4ypmA-5e7sA:41.6 | 4ypmA-5e7sA:96.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eue | PUTATIVESPHINGOSINE-1-PHOSPHATE LYASE (Symbiobacteriumthermophilum) |
PF00282(Pyridoxal_deC) | 5 | ALA A 148THR A 147LEU A 323GLY A 158ALA A 156 | None | 1.17A | 4ypmA-5eueA:undetectable | 4ypmA-5eueA:22.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eul | PROTEIN TRANSLOCASESUBUNIT SECY (Geobacillusthermodenitrificans) |
PF00344(SecY) | 5 | ALA Y 153THR Y 157LEU Y 150GLY Y 127SER Y 129 | None | 1.12A | 4ypmA-5eulY:undetectable | 4ypmA-5eulY:22.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ghs | SSDNA-SPECIFICEXONUCLEASE (Thermococcuskodakarensis) |
PF02272(DHHA1) | 5 | ALA A 304THR A 300LEU A 332GLY A 314ALA A 310 | None | 0.99A | 4ypmA-5ghsA:undetectable | 4ypmA-5ghsA:22.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h8y | SULFITE REDUCTASE[FERREDOXIN],CHLOROPLASTIC (Zea mays) |
PF01077(NIR_SIR)PF03460(NIR_SIR_ferr) | 5 | ALA A 284THR A 282LEU A 399GLY A 310SER A 302 | None | 1.20A | 4ypmA-5h8yA:2.2 | 4ypmA-5h8yA:20.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hgz | N-ALPHA-ACETYLTRANSFERASE 60 (Homo sapiens) |
PF00583(Acetyltransf_1) | 5 | ALA A 56THR A 58LEU A 18THR A 25GLY A 102 | NoneNoneNoneNoneACO A 301 (-3.4A) | 1.02A | 4ypmA-5hgzA:undetectable | 4ypmA-5hgzA:20.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hh0 | N-ALPHA-ACETYLTRANSFERASE 60 (Homo sapiens) |
PF00583(Acetyltransf_1) | 5 | ALA A 56THR A 58LEU A 18THR A 25GLY A 102 | NoneNoneNoneNoneCOA A 201 (-3.2A) | 1.02A | 4ypmA-5hh0A:undetectable | 4ypmA-5hh0A:20.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i2g | DIOL DEHYDRATASE (Roseburiainulinivorans) |
PF01228(Gly_radical)PF02901(PFL-like) | 5 | ALA A 671LEU A 744THR A 753GLY A 557ALA A 562 | None | 1.19A | 4ypmA-5i2gA:undetectable | 4ypmA-5i2gA:17.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5icv | N-ALPHA-ACETYLTRANSFERASE 60 (Homo sapiens) |
PF00583(Acetyltransf_1) | 5 | ALA A 56THR A 58LEU A 18THR A 25GLY A 102 | None | 1.04A | 4ypmA-5icvA:undetectable | 4ypmA-5icvA:18.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ijx | TYROSINE--TRNALIGASE,MITOCHONDRIAL (Coccidioidesposadasii) |
PF00579(tRNA-synt_1b) | 5 | THR A 354LEU A 359GLY A 416SER A 419ALA A 420 | None | 1.14A | 4ypmA-5ijxA:undetectable | 4ypmA-5ijxA:22.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j1d | PHOSPHATE BINDINGPROTEIN (Stenotrophomonasmaltophilia) |
PF12849(PBP_like_2) | 5 | ALA A 13THR A 205GLY A 225PRO A 226ALA A 228 | None | 1.19A | 4ypmA-5j1dA:undetectable | 4ypmA-5j1dA:20.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jla | PUTATIVE SHORT-CHAINDEHYDROGENASE/REDUCTASE (Paraburkholderiaxenovorans) |
PF13561(adh_short_C2) | 5 | THR A 117MET A 128GLY A 125PRO A 127ALA A 82 | None | 1.12A | 4ypmA-5jlaA:undetectable | 4ypmA-5jlaA:22.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k8c | 3-DEOXY-ALPHA-D-MANNO-OCTULOSONATE8-OXIDASE (Shewanellaoneidensis) |
PF00465(Fe-ADH) | 5 | THR A 102GLY A 145SER A 149ALA A 148LYS A 107 | NoneNoneNAD A 401 (-2.6A)NoneNAD A 401 ( 3.7A) | 1.23A | 4ypmA-5k8cA:undetectable | 4ypmA-5k8cA:23.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kkb | MANNOSYL-OLIGOSACCHARIDE1,2-ALPHA-MANNOSIDASE IA (Mus musculus) |
PF01532(Glyco_hydro_47) | 5 | ALA A 480THR A 477MET A 557THR A 509ALA A 485 | None | 1.22A | 4ypmA-5kkbA:undetectable | 4ypmA-5kkbA:23.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mg5 | HYDROXYMETHYLGLUTARYL-COA SYNTHASE (Pseudomonasprotegens) |
no annotation | 5 | ALA A 142THR A 144THR A 82GLY A 14ALA A 165 | None | 0.99A | 4ypmA-5mg5A:undetectable | 4ypmA-5mg5A:15.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mg5 | HYDROXYMETHYLGLUTARYL-COA SYNTHASE (Pseudomonasprotegens) |
no annotation | 5 | ALA A 142THR A 144THR A 82LEU A 80ALA A 63 | None | 1.11A | 4ypmA-5mg5A:undetectable | 4ypmA-5mg5A:15.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mg5 | HYDROXYMETHYLGLUTARYL-COA SYNTHASE (Pseudomonasprotegens) |
no annotation | 5 | ALA A 142THR A 144THR A 82LEU A 80ALA A 165 | None | 0.80A | 4ypmA-5mg5A:undetectable | 4ypmA-5mg5A:15.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mjv | CAPSID SUBUNIT VP1CAPSID SUBUNIT VP3 (Parechovirus A) |
no annotation | 5 | ALA B 63THR B 62LEU A 169PRO A 209ALA A 108 | None | 1.13A | 4ypmA-5mjvB:undetectable | 4ypmA-5mjvB:20.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ot0 | L-ASPARAGINASE (Thermococcuskodakarensis) |
no annotation | 5 | ALA A 295THR A 296GLY A 151SER A 92ALA A 89 | None | 1.22A | 4ypmA-5ot0A:undetectable | 4ypmA-5ot0A:24.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t5i | TUNGSTENFORMYLMETHANOFURANDEHYDROGENASESUBUNIT B (Methanothermobactersp. CaT2) |
PF00384(Molybdopterin) | 6 | THR B 294THR B 301GLY B 120PRO B 121SER B 122ALA B 125 | None | 1.45A | 4ypmA-5t5iB:undetectable | 4ypmA-5t5iB:22.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tr1 | CHLORIDE CHANNELPROTEIN (Bos taurus) |
PF00654(Voltage_CLC) | 5 | ALA A 368THR A 371THR A 401GLY A 441SER A 445 | None | 1.00A | 4ypmA-5tr1A:3.1 | 4ypmA-5tr1A:19.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5txr | 5-AMINOLEVULINATESYNTHASE,MITOCHONDRIAL (Saccharomycescerevisiae) |
no annotation | 5 | THR B 465THR B 463LYS B 337GLY B 287ALA B 285 | NoneNonePLP B 605 (-2.9A)NoneNone | 1.23A | 4ypmA-5txrB:undetectable | 4ypmA-5txrB:15.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uxn | PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATEALDOLASE (Pseudomonasaeruginosa) |
no annotation | 5 | THR A 268LEU A 302GLY A 291PRO A 292SER A 293 | None | 1.05A | 4ypmA-5uxnA:undetectable | 4ypmA-5uxnA:12.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c9b | PLP-DEPENDENTL-ARGININEHYDROXYLASE MPPP (Streptomyceswadayamensis) |
no annotation | 5 | ALA A 119LEU A 110THR A 156PRO A 344ALA A 342 | NoneNoneLLP A 221 ( 3.5A)NoneNone | 1.10A | 4ypmA-6c9bA:undetectable | 4ypmA-6c9bA:12.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cwx | RIBONUCLEASE PPROTEIN SUBUNIT P20RIBONUCLEASE PPROTEIN SUBUNIT P25 (Homo sapiens) |
no annotation | 5 | ALA A 100THR A 102THR B 95LEU B 97THR B 74 | NoneNoneNoneNoneCME B 70 ( 4.3A) | 1.22A | 4ypmA-6cwxA:undetectable | 4ypmA-6cwxA:12.96 |