SIMILAR PATTERNS OF AMINO ACIDS FOR 4YPM_A_BO2A801

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE


(Streptomyces
antibioticus)
PF00013
(KH_1)
PF01138
(RNase_PH)
PF03726
(PNPase)
5 THR A 123
LEU A  48
GLY A  35
SER A 144
ALA A  37
None
1.13A 4ypmA-1e3hA:
3.8
4ypmA-1e3hA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f20 NITRIC-OXIDE
SYNTHASE


(Rattus
norvegicus)
PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1)
5 ALA A1254
THR A1251
GLY A1030
PRO A1029
SER A1258
FAD  A1501 ( 3.7A)
NAP  A1502 ( 3.9A)
None
None
None
1.18A 4ypmA-1f20A:
undetectable
4ypmA-1f20A:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g5i MITOCHONDRIAL DNA
POLYMERASE ACCESSORY
SUBUNIT


(Mus musculus)
PF03129
(HGTP_anticodon)
5 THR A 418
LEU A 416
GLY A 390
PRO A 389
ALA A 358
None
1.18A 4ypmA-1g5iA:
undetectable
4ypmA-1g5iA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j2r HYPOTHETICAL
ISOCHORISMATASE
FAMILY PROTEIN YECD


(Escherichia
coli)
PF00857
(Isochorismatase)
5 ALA A 150
THR A 149
LEU A 137
PRO A 184
ALA A 187
None
1.22A 4ypmA-1j2rA:
undetectable
4ypmA-1j2rA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nba N-CARBAMOYLSARCOSINE
AMIDOHYDROLASE


(Arthrobacter
sp.)
PF00857
(Isochorismatase)
5 ALA A 185
LEU A 167
PRO A 151
SER A 148
ALA A 149
None
1.18A 4ypmA-1nbaA:
undetectable
4ypmA-1nbaA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odi PURINE NUCLEOSIDE
PHOSPHORYLASE


(Thermus
thermophilus)
PF01048
(PNP_UDP_1)
5 THR A  90
GLY A  66
PRO A  68
SER A  69
ALA A  70
SO4  A1236 ( 3.0A)
None
None
None
None
1.06A 4ypmA-1odiA:
undetectable
4ypmA-1odiA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qo8 FLAVOCYTOCHROME C3
FUMARATE REDUCTASE


(Shewanella
frigidimarina)
PF00890
(FAD_binding_2)
PF14537
(Cytochrom_c3_2)
5 THR A 255
LEU A 256
GLY A 158
SER A 156
ALA A 129
None
None
FAD  A 605 (-3.3A)
None
None
1.20A 4ypmA-1qo8A:
undetectable
4ypmA-1qo8A:
20.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rr9 ATP-DEPENDENT
PROTEASE LA


(Escherichia
coli)
PF05362
(Lon_C)
8 LEU A 611
MET A 634
THR A 673
LYS A 675
GLY A 677
PRO A 678
ALA A 680
LYS A 722
None
0.77A 4ypmA-1rr9A:
29.4
4ypmA-1rr9A:
38.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szn ALPHA-GALACTOSIDASE

(Trichoderma
reesei)
PF16499
(Melibiase_2)
5 ALA A 280
LEU A 307
THR A 405
GLY A 344
PRO A 345
None
1.11A 4ypmA-1sznA:
undetectable
4ypmA-1sznA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1thm THERMITASE

(Thermoactinomyces
vulgaris)
PF00082
(Peptidase_S8)
5 ALA A  93
THR A  92
GLY A  31
SER A 240
ALA A 239
None
1.15A 4ypmA-1thmA:
undetectable
4ypmA-1thmA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uek 4-(CYTIDINE
5'-DIPHOSPHO)-2C-MET
HYL-D-ERYTHRITOL
KINASE


(Thermus
thermophilus)
PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
5 ALA A   7
LEU A  35
GLY A  94
SER A  96
ALA A   5
None
1.17A 4ypmA-1uekA:
undetectable
4ypmA-1uekA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1whs SERINE
CARBOXYPEPTIDASE II


(Triticum
aestivum)
PF00450
(Peptidase_S10)
5 ALA A 229
THR A 226
LEU A 206
THR A 188
GLY A 196
None
1.20A 4ypmA-1whsA:
undetectable
4ypmA-1whsA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xhk PUTATIVE PROTEASE LA
HOMOLOG


(Methanocaldococcus
jannaschii)
PF05362
(Lon_C)
5 ALA A 466
GLY A 548
SER A 550
ALA A 551
LYS A 593
None
0.73A 4ypmA-1xhkA:
21.7
4ypmA-1xhkA:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xp8 RECA PROTEIN

(Deinococcus
radiodurans)
PF00154
(RecA)
5 THR A 259
LEU A  87
THR A  74
GLY A  78
PRO A  79
None
0.93A 4ypmA-1xp8A:
undetectable
4ypmA-1xp8A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zk7 MERCURIC REDUCTASE

(Pseudomonas
aeruginosa)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 ALA A 239
THR A 237
THR A 253
LEU A 251
THR A 203
None
1.03A 4ypmA-1zk7A:
undetectable
4ypmA-1zk7A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ado MEDIATOR OF DNA
DAMAGE CHECKPOINT
PROTEIN 1


(Homo sapiens)
PF16770
(RTT107_BRCT_5)
5 THR A1928
LEU A1926
THR A1934
GLY A1918
ALA A1923
None
1.05A 4ypmA-2adoA:
undetectable
4ypmA-2adoA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw5 BACTERIAL
FLUORINATING ENZYME
HOMOLOG


(Thermus
thermophilus)
PF01887
(SAM_adeno_trans)
5 ALA A  81
THR A  87
LEU A 154
PRO A  91
ALA A  79
None
0.89A 4ypmA-2cw5A:
undetectable
4ypmA-2cw5A:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eg3 PROBABLE THIOSULFATE
SULFURTRANSFERASE


(Thermus
thermophilus)
PF00581
(Rhodanese)
5 THR A 124
LEU A  84
GLY A 194
SER A 197
ALA A 198
None
1.05A 4ypmA-2eg3A:
undetectable
4ypmA-2eg3A:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1


(Crotalus atrox)
PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR)
5 ALA A 264
THR A 267
GLY A 298
PRO A 299
ALA A 301
None
1.22A 4ypmA-2erqA:
1.9
4ypmA-2erqA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2igt SAM DEPENDENT
METHYLTRANSFERASE


(Agrobacterium
fabrum)
PF10672
(Methyltrans_SAM)
5 LEU A 248
THR A 269
PRO A 243
SER A 242
ALA A 245
None
1.16A 4ypmA-2igtA:
undetectable
4ypmA-2igtA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2irw CORTICOSTEROID
11-BETA-DEHYDROGENAS
E ISOZYME 1


(Homo sapiens)
PF00106
(adh_short)
5 ALA A 154
THR A 151
LEU A 116
GLY A 112
ALA A 106
None
1.21A 4ypmA-2irwA:
2.2
4ypmA-2irwA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ixs SDAI RESTRICTION
ENDONUCLEASE


(Streptomyces
diastaticus)
PF06616
(BsuBI_PstI_RE)
5 THR A  88
THR A  38
LEU A  42
GLY A  96
ALA A 122
None
1.05A 4ypmA-2ixsA:
undetectable
4ypmA-2ixsA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jbw 2,6-DIHYDROXY-PSEUDO
-OXYNICOTINE
HYDROLASE


(Paenarthrobacter
nicotinovorans)
PF06500
(DUF1100)
5 ALA A 167
THR A 168
GLY A 136
PRO A 137
ALA A 205
None
1.09A 4ypmA-2jbwA:
undetectable
4ypmA-2jbwA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1f URIDINE
5'-MONOPHOSPHATE
SYNTHASE


(Homo sapiens)
PF00215
(OMPdecase)
5 ALA A 113
LEU A 109
THR A  93
GLY A  85
PRO A  86
None
1.20A 4ypmA-2p1fA:
undetectable
4ypmA-2p1fA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qcm URIDINE
5'-MONOPHOSPHATE
SYNTHASE (UMP
SYNTHASE)


(Homo sapiens)
PF00215
(OMPdecase)
5 ALA A 302
LEU A 298
THR A 282
GLY A 274
PRO A 275
None
1.21A 4ypmA-2qcmA:
undetectable
4ypmA-2qcmA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qne PUTATIVE
METHYLTRANSFERASE


(Desulfitobacterium
hafniense)
PF06253
(MTTB)
5 ALA A 274
THR A 272
LEU A 283
GLY A 236
PRO A 237
None
EDO  A 478 (-3.0A)
None
None
None
1.22A 4ypmA-2qneA:
undetectable
4ypmA-2qneA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7b BENZOATE-COENZYME A
LIGASE


(Paraburkholderia
xenovorans)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
5 ALA A 389
THR A 335
THR A 201
GLY A 385
PRO A 386
None
1.20A 4ypmA-2v7bA:
undetectable
4ypmA-2v7bA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7b BENZOATE-COENZYME A
LIGASE


(Paraburkholderia
xenovorans)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
5 THR A 335
THR A 201
THR A 402
GLY A 385
PRO A 386
None
1.19A 4ypmA-2v7bA:
undetectable
4ypmA-2v7bA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vjw GAF FAMILY PROTEIN

(Mycolicibacterium
smegmatis)
PF01590
(GAF)
5 ALA A 250
THR A 253
THR A 248
GLY A 316
ALA A 341
None
1.17A 4ypmA-2vjwA:
undetectable
4ypmA-2vjwA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w37 ORNITHINE
CARBAMOYLTRANSFERASE
, CATABOLIC


(Lactobacillus
hilgardii)
PF00185
(OTCace)
PF02729
(OTCace_N)
5 THR A 334
LEU A 335
PRO A  80
SER A  73
ALA A  78
None
1.22A 4ypmA-2w37A:
undetectable
4ypmA-2w37A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2woc ADP-RIBOSYL-[DINITRO
GEN REDUCTASE]
GLYCOHYDROLASE


(Rhodospirillum
rubrum)
PF03747
(ADP_ribosyl_GH)
5 ALA A 166
THR A 169
LEU A 170
GLY A 125
ALA A 128
None
1.18A 4ypmA-2wocA:
undetectable
4ypmA-2wocA:
21.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2x36 LON PROTEASE
HOMOLOG,
MITOCHONDRIAL


(Homo sapiens)
PF05362
(Lon_C)
7 ALA A 769
LEU A 778
GLY A 853
PRO A 854
SER A 855
ALA A 856
LYS A 898
None
0.79A 4ypmA-2x36A:
24.6
4ypmA-2x36A:
30.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2x36 LON PROTEASE
HOMOLOG,
MITOCHONDRIAL


(Homo sapiens)
PF05362
(Lon_C)
5 ALA A 769
THR A 771
PRO A 854
SER A 855
LYS A 898
None
0.75A 4ypmA-2x36A:
24.6
4ypmA-2x36A:
30.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdv MYC-INDUCED NUCLEAR
ANTIGEN


(Homo sapiens)
PF08007
(Cupin_4)
5 ALA A  72
THR A  75
PRO A  30
SER A  31
ALA A  32
None
1.21A 4ypmA-2xdvA:
undetectable
4ypmA-2xdvA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE


(Escherichia
coli)
PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C)
5 ALA A 227
THR A 174
THR A 208
THR A 151
GLY A 170
None
SO4  A 500 ( 4.8A)
SO4  A 500 (-3.6A)
None
None
1.15A 4ypmA-2xf8A:
undetectable
4ypmA-2xf8A:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zqe MUTS2 PROTEIN

(Thermus
thermophilus)
PF01713
(Smr)
5 LEU A  38
GLY A  69
PRO A  68
ALA A  66
LYS A  41
None
1.03A 4ypmA-2zqeA:
undetectable
4ypmA-2zqeA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3acz METHIONINE
GAMMA-LYASE


(Entamoeba
histolytica)
PF01053
(Cys_Met_Meta_PP)
5 THR A 306
MET A 300
THR A 182
GLY A 302
ALA A 296
None
None
LLP  A 205 ( 3.6A)
None
None
1.22A 4ypmA-3aczA:
undetectable
4ypmA-3aczA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bbj PUTATIVE
THIOESTERASE II


(Thermobifida
fusca)
PF13622
(4HBT_3)
5 ALA A  68
LEU A  40
GLY A  71
PRO A  72
ALA A  73
None
1.10A 4ypmA-3bbjA:
undetectable
4ypmA-3bbjA:
25.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwe 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE III


(Burkholderia
pseudomallei)
PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III)
5 ALA A 148
THR A 150
THR A  88
LEU A  86
ALA A 172
None
0.90A 4ypmA-3gweA:
undetectable
4ypmA-3gweA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3led 3-OXOACYL-ACYL
CARRIER PROTEIN
SYNTHASE III


(Rhodopseudomonas
palustris)
PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III)
5 ALA A 208
THR A 206
THR A   9
GLY A 162
ALA A 166
None
0.99A 4ypmA-3ledA:
undetectable
4ypmA-3ledA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lg5 EPI-ISOZIZAENE
SYNTHASE


(Streptomyces
coelicolor)
no annotation 5 ALA A 140
THR A 137
GLY A 129
PRO A 128
ALA A 124
None
1.13A 4ypmA-3lg5A:
undetectable
4ypmA-3lg5A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6a ATP-DEPENDENT
PROTEASE LA 1


(Bacillus
subtilis)
PF00004
(AAA)
PF05362
(Lon_C)
6 ALA A 600
LEU A 609
GLY A 675
PRO A 676
ALA A 678
LYS A 720
None
0.82A 4ypmA-3m6aA:
27.3
4ypmA-3m6aA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6a ATP-DEPENDENT
PROTEASE LA 1


(Bacillus
subtilis)
PF00004
(AAA)
PF05362
(Lon_C)
6 ALA A 600
THR A 602
GLY A 675
PRO A 676
ALA A 678
LYS A 720
None
1.01A 4ypmA-3m6aA:
27.3
4ypmA-3m6aA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6a ATP-DEPENDENT
PROTEASE LA 1


(Bacillus
subtilis)
PF00004
(AAA)
PF05362
(Lon_C)
6 ALA A 600
THR A 602
MET A 632
GLY A 675
PRO A 676
ALA A 678
None
1.19A 4ypmA-3m6aA:
27.3
4ypmA-3m6aA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6a ATP-DEPENDENT
PROTEASE LA 1


(Bacillus
subtilis)
PF00004
(AAA)
PF05362
(Lon_C)
5 THR A 603
LEU A 609
GLY A 675
PRO A 676
ALA A 678
None
1.17A 4ypmA-3m6aA:
27.3
4ypmA-3m6aA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nav TRYPTOPHAN SYNTHASE
ALPHA CHAIN


(Vibrio cholerae)
PF00290
(Trp_syntA)
5 ALA A 158
THR A 162
LEU A 163
THR A 174
PRO A 192
None
1.21A 4ypmA-3navA:
undetectable
4ypmA-3navA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nav TRYPTOPHAN SYNTHASE
ALPHA CHAIN


(Vibrio cholerae)
PF00290
(Trp_syntA)
5 ALA A 208
THR A 174
LEU A 176
GLY A 227
ALA A 223
None
0.92A 4ypmA-3navA:
undetectable
4ypmA-3navA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nd0 SLL0855 PROTEIN

(Synechocystis
sp. PCC 6803)
PF00654
(Voltage_CLC)
5 ALA A 141
LEU A 135
THR A 147
GLY A 102
ALA A 344
None
1.07A 4ypmA-3nd0A:
undetectable
4ypmA-3nd0A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyq MALONYL-COA LIGASE

(Streptomyces
coelicolor)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
5 THR A 293
THR A 366
GLY A 340
PRO A 341
ALA A 159
None
1.11A 4ypmA-3nyqA:
undetectable
4ypmA-3nyqA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o03 DEHYDROGENASE WITH
DIFFERENT
SPECIFICITIES


(Streptococcus
suis)
PF13561
(adh_short_C2)
5 ALA A 243
LEU A  12
SER A 247
ALA A 246
LYS A 144
None
1.17A 4ypmA-3o03A:
2.3
4ypmA-3o03A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3org CMCLC

(Cyanidioschyzon
merolae)
PF00654
(Voltage_CLC)
5 ALA A 290
LEU A 287
GLY A 257
SER A 254
ALA A 253
None
1.18A 4ypmA-3orgA:
undetectable
4ypmA-3orgA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3px2 N-METHYLTRANSFERASE

(Streptomyces
fradiae)
PF13649
(Methyltransf_25)
6 ALA A 113
THR A 115
LEU A  54
PRO A  49
SER A  48
ALA A  51
None
1.48A 4ypmA-3px2A:
undetectable
4ypmA-3px2A:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qpb URIDINE
PHOSPHORYLASE


(Streptococcus
pyogenes)
PF01048
(PNP_UDP_1)
5 THR A  97
GLY A  73
PRO A  75
SER A  76
ALA A  77
R1P  A1254 (-3.0A)
None
None
None
None
1.03A 4ypmA-3qpbA:
undetectable
4ypmA-3qpbA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qsz STAR-RELATED LIPID
TRANSFER PROTEIN


(Xanthomonas
citri)
PF01852
(START)
5 ALA A 181
THR A 184
GLY A 173
PRO A 172
ALA A 170
None
1.00A 4ypmA-3qszA:
undetectable
4ypmA-3qszA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wad GLYCOSYLTRANSFERASE

(Streptomyces
halstedii)
PF06722
(DUF1205)
5 THR A 283
THR A 325
GLY A 231
PRO A 232
ALA A 233
None
1.19A 4ypmA-3wadA:
undetectable
4ypmA-3wadA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wo0 ALANINE-ANTICAPSIN
LIGASE BACD


(Bacillus
subtilis)
PF13535
(ATP-grasp_4)
5 ALA A 327
THR A 308
LEU A 303
PRO A 114
ALA A 116
None
1.10A 4ypmA-3wo0A:
undetectable
4ypmA-3wo0A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0s OCTENOYL-COA
REDUCTASE/CARBOXYLAS
E


(Streptomyces
cinnabarigriseus)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 ALA A 444
THR A 445
GLY A 231
SER A 230
ALA A 260
None
None
NAP  A1447 (-3.3A)
NAP  A1447 (-3.6A)
None
1.16A 4ypmA-4a0sA:
undetectable
4ypmA-4a0sA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0s OCTENOYL-COA
REDUCTASE/CARBOXYLAS
E


(Streptomyces
cinnabarigriseus)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 ALA A 444
THR A 445
GLY A 407
SER A 230
ALA A 260
None
None
None
NAP  A1447 (-3.6A)
None
1.09A 4ypmA-4a0sA:
undetectable
4ypmA-4a0sA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cr2 26S PROTEASE
REGULATORY SUBUNIT 4
HOMOLOG


(Saccharomyces
cerevisiae)
PF00004
(AAA)
5 ALA I 242
THR I 240
LEU I 202
LYS I 323
ALA I 275
None
1.22A 4ypmA-4cr2I:
2.9
4ypmA-4cr2I:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czp EXTRALONG MANGANESE
PEROXIDASE


(Gelatoporia
subvermispora)
PF00141
(peroxidase)
PF11895
(Peroxidase_ext)
5 LYS A  54
GLY A  56
PRO A  57
SER A  58
ALA A  59
None
0.99A 4ypmA-4czpA:
undetectable
4ypmA-4czpA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hmw PYRIDOXAMINE
5'-PHOSPHATE OXIDASE


(Burkholderia
lata)
PF01243
(Putative_PNPOx)
PF10590
(PNP_phzG_C)
5 ALA A  95
THR A  53
LEU A  51
THR A  79
PRO A 179
None
None
None
FMN  A 301 (-3.7A)
None
1.18A 4ypmA-4hmwA:
undetectable
4ypmA-4hmwA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idm DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE


(Mycobacterium
tuberculosis)
PF00171
(Aldedh)
5 ALA A 471
THR A 470
LEU A 445
GLY A 458
ALA A 478
None
1.13A 4ypmA-4idmA:
2.8
4ypmA-4idmA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4itx CYSTATHIONINE
BETA-LYASE METC


(Escherichia
coli)
PF01053
(Cys_Met_Meta_PP)
5 ALA A 249
THR A 252
LEU A  67
THR A 222
GLY A  60
None
1.21A 4ypmA-4itxA:
undetectable
4ypmA-4itxA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jjj CELLULOSE
1,4-BETA-CELLOBIOSID
ASE


(Thermobifida
fusca)
PF02011
(Glyco_hydro_48)
6 ALA A 503
THR A 502
LEU A 532
THR A 543
ALA A 627
LYS A 507
None
1.37A 4ypmA-4jjjA:
undetectable
4ypmA-4jjjA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ldp NDP-FOROSAMYLTRANSFE
RASE


(Saccharopolyspora
spinosa)
PF06722
(DUF1205)
5 THR A 294
THR A 336
GLY A 231
PRO A 232
ALA A 233
None
1.23A 4ypmA-4ldpA:
undetectable
4ypmA-4ldpA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lhb MOLYBDOPTERIN
ADENYLYLTRANSFERASE


(Pyrococcus
furiosus)
PF00994
(MoCF_biosynth)
5 ALA A 125
THR A 123
LEU A 142
THR A 151
ALA A 127
None
1.19A 4ypmA-4lhbA:
undetectable
4ypmA-4lhbA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8r HYPOTHETICAL PROTEIN

(Bacteroides
caccae)
PF16023
(DUF4784)
5 ALA A 229
LEU A 240
GLY A 283
PRO A 282
ALA A 219
None
None
None
EDO  A 506 (-4.4A)
None
1.06A 4ypmA-4m8rA:
undetectable
4ypmA-4m8rA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqy (S)-IMINE REDUCTASE

(Streptomyces
sp. GF3546)
PF03446
(NAD_binding_2)
5 ALA A  90
LEU A 149
THR A 133
GLY A 137
PRO A 138
None
1.20A 4ypmA-4oqyA:
undetectable
4ypmA-4oqyA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh0 SPORE PHOTOPRODUCT
LYASE


(Geobacillus
thermodenitrificans)
no annotation 5 ALA A 140
THR A 141
PRO A  78
SER A  79
ALA A  80
None
SO4  A 403 (-3.0A)
None
None
None
1.21A 4ypmA-4rh0A:
undetectable
4ypmA-4rh0A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wpg DTDP-4-DEHYDRORHAMNO
SE REDUCTASE


(Streptococcus
pyogenes)
PF04321
(RmlD_sub_bind)
5 ALA A  59
THR A  61
THR A 150
GLY A 134
SER A  82
None
1.19A 4ypmA-4wpgA:
undetectable
4ypmA-4wpgA:
19.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ypl LON PROTEASE

(Meiothermus
taiwanensis)
PF00004
(AAA)
PF05362
(Lon_C)
12 ALA A 601
THR A 603
THR A 608
LEU A 610
MET A 633
THR A 672
LYS A 674
GLY A 676
PRO A 677
SER A 678
ALA A 679
LYS A 721
4KZ  A 801 (-3.3A)
4KZ  A 801 ( 4.5A)
None
4KZ  A 801 (-4.2A)
4KZ  A 801 (-3.6A)
None
None
4KZ  A 801 (-3.3A)
4KZ  A 801 (-4.3A)
4KZ  A 801 (-1.4A)
4KZ  A 801 (-3.5A)
4KZ  A 801 (-3.4A)
0.57A 4ypmA-4yplA:
34.6
4ypmA-4yplA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z9x GLUCONATE
5-DEHYDROGENASE


(Streptococcus
pyogenes)
PF13561
(adh_short_C2)
5 ALA A 238
LEU A   7
SER A 242
ALA A 241
LYS A 139
None
1.13A 4ypmA-4z9xA:
2.7
4ypmA-4z9xA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a4j FORMATE--TETRAHYDROF
OLATE LIGASE


(Tepidanaerobacter
acetatoxydans)
PF01268
(FTHFS)
5 ALA A 267
THR A 265
LEU A  95
MET A 121
PRO A 120
None
0.92A 4ypmA-5a4jA:
undetectable
4ypmA-5a4jA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b5u L-ASPARAGINASE

(Pyrococcus
furiosus)
PF00710
(Asparaginase)
no annotation
5 ALA B 294
THR B 295
GLY A 149
SER A  90
ALA A  87
None
1.11A 4ypmA-5b5uB:
undetectable
4ypmA-5b5uB:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cu1 DMSP LYASE

(Ruegeria
pomeroyi)
PF16867
(DMSP_lyase)
5 ALA A 113
LEU A 188
GLY A 105
PRO A 106
ALA A 108
None
1.22A 4ypmA-5cu1A:
undetectable
4ypmA-5cu1A:
20.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e7s LON PROTEASE

(Meiothermus
taiwanensis)
PF05362
(Lon_C)
9 LEU A 610
MET A 633
THR A 672
LYS A 674
GLY A 676
PRO A 677
SER A 678
ALA A 679
LYS A 721
None
0.71A 4ypmA-5e7sA:
41.6
4ypmA-5e7sA:
96.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eue PUTATIVE
SPHINGOSINE-1-PHOSPH
ATE LYASE


(Symbiobacterium
thermophilum)
PF00282
(Pyridoxal_deC)
5 ALA A 148
THR A 147
LEU A 323
GLY A 158
ALA A 156
None
1.17A 4ypmA-5eueA:
undetectable
4ypmA-5eueA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eul PROTEIN TRANSLOCASE
SUBUNIT SECY


(Geobacillus
thermodenitrificans)
PF00344
(SecY)
5 ALA Y 153
THR Y 157
LEU Y 150
GLY Y 127
SER Y 129
None
1.12A 4ypmA-5eulY:
undetectable
4ypmA-5eulY:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ghs SSDNA-SPECIFIC
EXONUCLEASE


(Thermococcus
kodakarensis)
PF02272
(DHHA1)
5 ALA A 304
THR A 300
LEU A 332
GLY A 314
ALA A 310
None
0.99A 4ypmA-5ghsA:
undetectable
4ypmA-5ghsA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h8y SULFITE REDUCTASE
[FERREDOXIN],
CHLOROPLASTIC


(Zea mays)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr)
5 ALA A 284
THR A 282
LEU A 399
GLY A 310
SER A 302
None
1.20A 4ypmA-5h8yA:
2.2
4ypmA-5h8yA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hgz N-ALPHA-ACETYLTRANSF
ERASE 60


(Homo sapiens)
PF00583
(Acetyltransf_1)
5 ALA A  56
THR A  58
LEU A  18
THR A  25
GLY A 102
None
None
None
None
ACO  A 301 (-3.4A)
1.02A 4ypmA-5hgzA:
undetectable
4ypmA-5hgzA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hh0 N-ALPHA-ACETYLTRANSF
ERASE 60


(Homo sapiens)
PF00583
(Acetyltransf_1)
5 ALA A  56
THR A  58
LEU A  18
THR A  25
GLY A 102
None
None
None
None
COA  A 201 (-3.2A)
1.02A 4ypmA-5hh0A:
undetectable
4ypmA-5hh0A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2g DIOL DEHYDRATASE

(Roseburia
inulinivorans)
PF01228
(Gly_radical)
PF02901
(PFL-like)
5 ALA A 671
LEU A 744
THR A 753
GLY A 557
ALA A 562
None
1.19A 4ypmA-5i2gA:
undetectable
4ypmA-5i2gA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5icv N-ALPHA-ACETYLTRANSF
ERASE 60


(Homo sapiens)
PF00583
(Acetyltransf_1)
5 ALA A  56
THR A  58
LEU A  18
THR A  25
GLY A 102
None
1.04A 4ypmA-5icvA:
undetectable
4ypmA-5icvA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL


(Coccidioides
posadasii)
PF00579
(tRNA-synt_1b)
5 THR A 354
LEU A 359
GLY A 416
SER A 419
ALA A 420
None
1.14A 4ypmA-5ijxA:
undetectable
4ypmA-5ijxA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1d PHOSPHATE BINDING
PROTEIN


(Stenotrophomonas
maltophilia)
PF12849
(PBP_like_2)
5 ALA A  13
THR A 205
GLY A 225
PRO A 226
ALA A 228
None
1.19A 4ypmA-5j1dA:
undetectable
4ypmA-5j1dA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jla PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE


(Paraburkholderia
xenovorans)
PF13561
(adh_short_C2)
5 THR A 117
MET A 128
GLY A 125
PRO A 127
ALA A  82
None
1.12A 4ypmA-5jlaA:
undetectable
4ypmA-5jlaA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8c 3-DEOXY-ALPHA-D-MANN
O-OCTULOSONATE
8-OXIDASE


(Shewanella
oneidensis)
PF00465
(Fe-ADH)
5 THR A 102
GLY A 145
SER A 149
ALA A 148
LYS A 107
None
None
NAD  A 401 (-2.6A)
None
NAD  A 401 ( 3.7A)
1.23A 4ypmA-5k8cA:
undetectable
4ypmA-5k8cA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kkb MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E IA


(Mus musculus)
PF01532
(Glyco_hydro_47)
5 ALA A 480
THR A 477
MET A 557
THR A 509
ALA A 485
None
1.22A 4ypmA-5kkbA:
undetectable
4ypmA-5kkbA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE


(Pseudomonas
protegens)
no annotation 5 ALA A 142
THR A 144
THR A  82
GLY A  14
ALA A 165
None
0.99A 4ypmA-5mg5A:
undetectable
4ypmA-5mg5A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE


(Pseudomonas
protegens)
no annotation 5 ALA A 142
THR A 144
THR A  82
LEU A  80
ALA A  63
None
1.11A 4ypmA-5mg5A:
undetectable
4ypmA-5mg5A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE


(Pseudomonas
protegens)
no annotation 5 ALA A 142
THR A 144
THR A  82
LEU A  80
ALA A 165
None
0.80A 4ypmA-5mg5A:
undetectable
4ypmA-5mg5A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mjv CAPSID SUBUNIT VP1
CAPSID SUBUNIT VP3


(Parechovirus A)
no annotation 5 ALA B  63
THR B  62
LEU A 169
PRO A 209
ALA A 108
None
1.13A 4ypmA-5mjvB:
undetectable
4ypmA-5mjvB:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ot0 L-ASPARAGINASE

(Thermococcus
kodakarensis)
no annotation 5 ALA A 295
THR A 296
GLY A 151
SER A  92
ALA A  89
None
1.22A 4ypmA-5ot0A:
undetectable
4ypmA-5ot0A:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t5i TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE
SUBUNIT B


(Methanothermobacter
sp. CaT2)
PF00384
(Molybdopterin)
6 THR B 294
THR B 301
GLY B 120
PRO B 121
SER B 122
ALA B 125
None
1.45A 4ypmA-5t5iB:
undetectable
4ypmA-5t5iB:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tr1 CHLORIDE CHANNEL
PROTEIN


(Bos taurus)
PF00654
(Voltage_CLC)
5 ALA A 368
THR A 371
THR A 401
GLY A 441
SER A 445
None
1.00A 4ypmA-5tr1A:
3.1
4ypmA-5tr1A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5txr 5-AMINOLEVULINATE
SYNTHASE,
MITOCHONDRIAL


(Saccharomyces
cerevisiae)
no annotation 5 THR B 465
THR B 463
LYS B 337
GLY B 287
ALA B 285
None
None
PLP  B 605 (-2.9A)
None
None
1.23A 4ypmA-5txrB:
undetectable
4ypmA-5txrB:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uxn PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE


(Pseudomonas
aeruginosa)
no annotation 5 THR A 268
LEU A 302
GLY A 291
PRO A 292
SER A 293
None
1.05A 4ypmA-5uxnA:
undetectable
4ypmA-5uxnA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9b PLP-DEPENDENT
L-ARGININE
HYDROXYLASE MPPP


(Streptomyces
wadayamensis)
no annotation 5 ALA A 119
LEU A 110
THR A 156
PRO A 344
ALA A 342
None
None
LLP  A 221 ( 3.5A)
None
None
1.10A 4ypmA-6c9bA:
undetectable
4ypmA-6c9bA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cwx RIBONUCLEASE P
PROTEIN SUBUNIT P20
RIBONUCLEASE P
PROTEIN SUBUNIT P25


(Homo sapiens)
no annotation 5 ALA A 100
THR A 102
THR B  95
LEU B  97
THR B  74
None
None
None
None
CME  B  70 ( 4.3A)
1.22A 4ypmA-6cwxA:
undetectable
4ypmA-6cwxA:
12.96