SIMILAR PATTERNS OF AMINO ACIDS FOR 4YPA_C_SAMC2304_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hdi | PHOSPHOGLYCERATEKINASE (Sus scrofa) |
PF00162(PGK) | 5 | GLY A 365HIS A 390TYR A 195GLN A 332ILE A 369 | None | 1.27A | 4ypaC-1hdiA:undetectable | 4ypaC-1hdiA:20.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mvh | CRYPTIC LOCIREGULATOR 4 (Schizosaccharomycespombe) |
PF00856(SET)PF05033(Pre-SET) | 5 | LYS A 338GLY A 339TRP A 340ASN A 409HIS A 410 | None | 1.05A | 4ypaC-1mvhA:16.2 | 4ypaC-1mvhA:29.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1peg | HISTONE H3METHYLTRANSFERASEDIM-5 (Neurosporacrassa) |
PF00856(SET)PF05033(Pre-SET) | 6 | GLY A 160TRP A 161ASN A 241HIS A 242TYR A 283CYH A 306 | SAH A 319 ( 4.6A)SAH A 319 (-4.8A)SAH A 319 (-3.6A)SAH A 319 (-4.3A)SAH A 319 (-4.7A) ZN A 4 ( 2.3A) | 0.57A | 4ypaC-1pegA:18.5 | 4ypaC-1pegA:29.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1peg | HISTONE H3METHYLTRANSFERASEDIM-5 (Neurosporacrassa) |
PF00856(SET)PF05033(Pre-SET) | 6 | GLY A 160TRP A 161ASN A 241HIS A 242TYR A 283CYH A 308 | SAH A 319 ( 4.6A)SAH A 319 (-4.8A)SAH A 319 (-3.6A)SAH A 319 (-4.3A)SAH A 319 (-4.7A) ZN A 4 (-2.2A) | 1.18A | 4ypaC-1pegA:18.5 | 4ypaC-1pegA:29.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1peg | HISTONE H3METHYLTRANSFERASEDIM-5 (Neurosporacrassa) |
PF00856(SET)PF05033(Pre-SET) | 6 | TRP A 161ASP A 202ASN A 241HIS A 242TYR A 283CYH A 306 | SAH A 319 (-4.8A)SAH A 319 (-3.6A)SAH A 319 (-3.6A)SAH A 319 (-4.3A)SAH A 319 (-4.7A) ZN A 4 ( 2.3A) | 0.63A | 4ypaC-1pegA:18.5 | 4ypaC-1pegA:29.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2afh | NITROGENASEMOLYBDENUM-IRONPROTEIN (Azotobactervinelandii) |
PF00148(Oxidored_nitro)PF11844(DUF3364) | 5 | TRP B 370ASP B 372HIS B 297GLN B 294ILE B 318 | None | 1.21A | 4ypaC-2afhB:undetectable | 4ypaC-2afhB:18.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r3a | HISTONE-LYSINEN-METHYLTRANSFERASESUV39H2 (Homo sapiens) |
PF00856(SET)PF05033(Pre-SET) | 7 | GLY A 151TRP A 152ASN A 219HIS A 220TYR A 261CYH A 287LYS A 288 | SAM A 304 (-3.5A)NoneSAM A 304 (-3.3A)SAM A 304 (-4.9A)SAM A 304 (-4.9A) ZN A 300 ( 2.3A)None | 0.69A | 4ypaC-2r3aA:19.2 | 4ypaC-2r3aA:28.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r3a | HISTONE-LYSINEN-METHYLTRANSFERASESUV39H2 (Homo sapiens) |
PF00856(SET)PF05033(Pre-SET) | 5 | GLY A 151TRP A 152HIS A 220TYR A 261CYH A 289 | SAM A 304 (-3.5A)NoneSAM A 304 (-4.9A)SAM A 304 (-4.9A) ZN A 300 ( 2.3A) | 1.29A | 4ypaC-2r3aA:19.2 | 4ypaC-2r3aA:28.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w5z | HISTONE-LYSINEN-METHYLTRANSFERASEHRX (Homo sapiens) |
PF00856(SET) | 5 | GLY A3840ASN A3906HIS A3907TYR A3944CYH A3957 | SAH A4971 ( 3.7A)SAH A4971 (-3.1A)SAH A4971 (-4.7A)SAH A4971 (-4.9A) ZN A4970 ( 2.3A) | 0.26A | 4ypaC-2w5zA:14.3 | 4ypaC-2w5zA:27.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w5z | HISTONE-LYSINEN-METHYLTRANSFERASEHRX (Homo sapiens) |
PF00856(SET) | 5 | GLY A3840ASN A3906HIS A3907TYR A3944CYH A3959 | SAH A4971 ( 3.7A)SAH A4971 (-3.1A)SAH A4971 (-4.7A)SAH A4971 (-4.9A) ZN A4970 (-2.3A) | 1.16A | 4ypaC-2w5zA:14.3 | 4ypaC-2w5zA:27.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bo5 | HISTONE-LYSINEN-METHYLTRANSFERASESETMAR (Homo sapiens) |
PF00856(SET)PF05033(Pre-SET) | 7 | LYS A 135GLY A 136TRP A 137ASN A 209HIS A 210TYR A 248CYH A 273 | NoneSAH A 305 (-3.8A)NoneSAH A 305 (-3.4A)NoneSAH A 305 (-4.9A) ZN A 304 ( 2.3A) | 0.23A | 4ypaC-3bo5A:20.4 | 4ypaC-3bo5A:28.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bo5 | HISTONE-LYSINEN-METHYLTRANSFERASESETMAR (Homo sapiens) |
PF00856(SET)PF05033(Pre-SET) | 6 | LYS A 135GLY A 136TRP A 137HIS A 210TYR A 248CYH A 275 | NoneSAH A 305 (-3.8A)NoneNoneSAH A 305 (-4.9A) ZN A 304 ( 2.3A) | 1.46A | 4ypaC-3bo5A:20.4 | 4ypaC-3bo5A:28.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n71 | HISTONE LYSINEMETHYLTRANSFERASESMYD1 (Mus musculus) |
PF00856(SET)PF01753(zf-MYND) | 5 | LYS A 17GLY A 16HIS A 206TYR A 252CYH A 274 | SFG A 491 (-4.7A)NoneNoneSFG A 491 (-4.8A) ZN A 497 (-2.2A) | 1.34A | 4ypaC-3n71A:6.0 | 4ypaC-3n71A:18.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n71 | HISTONE LYSINEMETHYLTRANSFERASESMYD1 (Mus musculus) |
PF00856(SET)PF01753(zf-MYND) | 6 | LYS A 17GLY A 18ASN A 205HIS A 206TYR A 252CYH A 274 | SFG A 491 (-4.7A)SFG A 491 ( 4.2A)SFG A 491 (-3.3A)NoneSFG A 491 (-4.8A) ZN A 497 (-2.2A) | 0.79A | 4ypaC-3n71A:6.0 | 4ypaC-3n71A:18.45 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ooi | HISTONE-LYSINEN-METHYLTRANSFERASE,H3 LYSINE-36 AND H4LYSINE-20 SPECIFIC (Homo sapiens) |
PF00856(SET) | 7 | GLY A 102TRP A 103ASN A 169HIS A 170TYR A 207CYH A 219LYS A 220 | SAM A 237 ( 3.7A)NoneSAM A 237 (-3.3A)SAM A 237 (-4.7A)None ZN A 232 ( 2.3A)None | 0.56A | 4ypaC-3ooiA:26.7 | 4ypaC-3ooiA:41.25 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ope | PROBABLEHISTONE-LYSINEN-METHYLTRANSFERASEASH1L (Homo sapiens) |
PF00856(SET) | 7 | LYS A2150GLY A2151TRP A2152ASN A2217HIS A2218TYR A2255CYH A2270 | NoneSAM A 7 (-3.4A)NoneSAM A 7 (-3.9A)NoneNone ZN A 1 (-2.7A) | 1.28A | 4ypaC-3opeA:32.8 | 4ypaC-3opeA:97.79 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ope | PROBABLEHISTONE-LYSINEN-METHYLTRANSFERASEASH1L (Homo sapiens) |
PF00856(SET) | 11 | LYS A2150GLY A2151TRP A2152ASP A2192ASN A2217HIS A2218TYR A2255GLN A2266CYH A2268LYS A2269ILE A2279 | NoneSAM A 7 (-3.4A)NoneSAM A 7 (-3.9A)SAM A 7 (-3.9A)NoneNoneSAM A 7 (-2.9A) ZN A 1 ( 2.5A)NoneNone | 0.51A | 4ypaC-3opeA:32.8 | 4ypaC-3opeA:97.79 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ope | PROBABLEHISTONE-LYSINEN-METHYLTRANSFERASEASH1L (Homo sapiens) |
PF00856(SET) | 7 | LYS A2150HIS A2193ASN A2217HIS A2218TYR A2255CYH A2268ILE A2279 | NoneNoneSAM A 7 (-3.9A)NoneNone ZN A 1 ( 2.5A)None | 1.12A | 4ypaC-3opeA:32.8 | 4ypaC-3opeA:97.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4d28 | CBL-INTERACTINGSERINE/THREONINE-PROTEIN KINASE 24 (Arabidopsisthaliana) |
PF00069(Pkinase) | 5 | LYS A 128GLY A 129HIS A 132HIS A 68ILE A 71 | None | 1.30A | 4ypaC-4d28A:undetectable | 4ypaC-4d28A:18.49 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4fmu | HISTONE-LYSINEN-METHYLTRANSFERASESETD2 (Homo sapiens) |
PF00856(SET) | 7 | LYS A1560GLY A1561TRP A1562ASN A1628HIS A1629GLN A1676CYH A1678 | None0UM A1804 (-3.5A)None0UM A1804 (-3.3A)None0UM A1804 (-3.3A) ZN A1803 ( 2.2A) | 0.44A | 4ypaC-4fmuA:25.6 | 4ypaC-4fmuA:37.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g34 | EUKARYOTICTRANSLATIONINITIATION FACTOR2-ALPHA KINASE 3 (Homo sapiens) |
PF00069(Pkinase) | 5 | LYS A 930GLY A 931HIS A 934HIS A 647ILE A 650 | None | 1.45A | 4ypaC-4g34A:undetectable | 4ypaC-4g34A:19.63 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4mi5 | HISTONE-LYSINEN-METHYLTRANSFERASEEZH2 (Homo sapiens) |
PF00856(SET) | 5 | GLY A 628TRP A 629ASN A 693HIS A 694TYR A 731 | None | 0.67A | 4ypaC-4mi5A:15.4 | 4ypaC-4mi5A:30.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qeo | HISTONE-LYSINEN-METHYLTRANSFERASE,H3 LYSINE-9 SPECIFICSUVH4 (Arabidopsisthaliana) |
PF00856(SET)PF02182(SAD_SRA)PF05033(Pre-SET) | 7 | LYS A 456GLY A 457TRP A 458ASN A 551HIS A 552TYR A 593CYH A 612 | SAH A 801 (-4.7A)SAH A 801 (-3.6A)SAH A 801 (-4.9A)SAH A 801 (-3.2A)NoneNone ZN A 805 ( 2.4A) | 0.44A | 4ypaC-4qeoA:17.1 | 4ypaC-4qeoA:19.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qeo | HISTONE-LYSINEN-METHYLTRANSFERASE,H3 LYSINE-9 SPECIFICSUVH4 (Arabidopsisthaliana) |
PF00856(SET)PF02182(SAD_SRA)PF05033(Pre-SET) | 6 | LYS A 456GLY A 457TRP A 458HIS A 552TYR A 593CYH A 614 | SAH A 801 (-4.7A)SAH A 801 (-3.6A)SAH A 801 (-4.9A)NoneNone ZN A 805 ( 2.4A) | 1.49A | 4ypaC-4qeoA:17.1 | 4ypaC-4qeoA:19.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rjz | ABC TRANSPORTER,SUBSTRATE BINDINGPROTEIN (SUGAR) (Agrobacteriumfabrum) |
PF01547(SBP_bac_1) | 5 | GLY A 297ASN A 90HIS A 93LYS A 139ILE A 88 | None | 1.19A | 4ypaC-4rjzA:undetectable | 4ypaC-4rjzA:17.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4upl | SULFATASE FAMILYPROTEIN (Ruegeriapomeroyi) |
PF00884(Sulfatase)PF16347(DUF4976) | 5 | ASP A 14HIS A 21TYR A 292GLN A 251ILE A 289 | None | 1.26A | 4ypaC-4uplA:undetectable | 4ypaC-4uplA:15.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4w2r | ENHANCER OF ZESTE 2POLYCOMB REPRESSIVECOMPLEX 2 SUBUNIT (Anoliscarolinensis) |
no annotation | 5 | GLY A 520TRP A 521ASN A 585HIS A 586TYR A 623 | CJD A 708 (-3.6A)NoneCJD A 708 (-3.5A)NoneNone | 0.54A | 4ypaC-4w2rA:21.8 | 4ypaC-4w2rA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z11 | AURONE SYNTHASE (Coreopsisgrandiflora) |
PF00264(Tyrosinase)PF12142(PPO1_DWL)PF12143(PPO1_KFDV) | 5 | GLY A 245HIS A 458HIS A 256GLN A 455ILE A 456 | NoneNone CU A 701 (-3.1A)NoneNone | 1.35A | 4ypaC-4z11A:undetectable | 4ypaC-4z11A:18.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z4p | HISTONE-LYSINEN-METHYLTRANSFERASE2D (Homo sapiens) |
PF00856(SET) | 5 | GLY A5408ASN A5474HIS A5475TYR A5512CYH A5525 | SAH A5602 (-3.6A)SAH A5602 (-3.1A)NoneNone ZN A5601 ( 2.2A) | 0.29A | 4ypaC-4z4pA:16.6 | 4ypaC-4z4pA:23.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z4p | HISTONE-LYSINEN-METHYLTRANSFERASE2D (Homo sapiens) |
PF00856(SET) | 5 | GLY A5408ASN A5474HIS A5475TYR A5512CYH A5527 | SAH A5602 (-3.6A)SAH A5602 (-3.1A)NoneNone ZN A5601 ( 2.2A) | 1.07A | 4ypaC-4z4pA:16.6 | 4ypaC-4z4pA:23.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f59 | HISTONE-LYSINEN-METHYLTRANSFERASE2C (Homo sapiens) |
PF00856(SET) | 5 | GLY A4782ASN A4848HIS A4849TYR A4886CYH A4899 | SAH A5002 (-3.5A)SAH A5002 (-2.7A)SAH A5002 (-4.6A)None ZN A5001 ( 2.0A) | 0.32A | 4ypaC-5f59A:16.5 | 4ypaC-5f59A:24.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f6l | HISTONE-LYSINEN-METHYLTRANSFERASE2A (Homo sapiens) |
PF00856(SET) | 5 | GLY A3840ASN A3906HIS A3907TYR A3944CYH A3957 | SAH A4001 (-3.4A)SAH A4001 (-3.0A)SAH A4001 (-4.9A)SAH A4001 (-4.9A) ZN A4002 ( 2.3A) | 0.26A | 4ypaC-5f6lA:15.8 | 4ypaC-5f6lA:24.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kjm | N-LYSINEMETHYLTRANSFERASESMYD2 (Homo sapiens) |
PF00856(SET)PF01753(zf-MYND) | 6 | LYS A 17GLY A 18ASN A 206HIS A 207TYR A 240CYH A 262 | NoneSAM A 501 ( 4.1A)SAM A 501 (-3.2A)None6TM A 502 ( 3.6A) ZN A 505 (-2.3A) | 1.01A | 4ypaC-5kjmA:6.4 | 4ypaC-5kjmA:20.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ls6 | HISTONE-LYSINEN-METHYLTRANSFERASEEZH2,HISTONE-LYSINEN-METHYLTRANSFERASEEZH2,HISTONE-LYSINEN-METHYLTRANSFERASEEZH2 (Homo sapiens) |
PF00856(SET)PF11616(EZH2_WD-Binding) | 5 | GLY A 623TRP A 624ASN A 688HIS A 689TYR A 726 | 74D A 809 ( 3.9A)None74D A 809 (-3.0A)NoneNone | 0.72A | 4ypaC-5ls6A:18.8 | 4ypaC-5ls6A:14.69 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5lsu | HISTONE-LYSINEN-METHYLTRANSFERASENSD2 (Homo sapiens) |
PF00856(SET) | 6 | GLY A1074TRP A1075ASN A1141HIS A1142TYR A1179CYH A1191 | SAM A1304 ( 3.2A)NoneSAM A1304 (-2.9A)SAM A1304 (-4.6A)SAM A1304 (-4.1A) ZN A1301 ( 2.3A) | 0.29A | 4ypaC-5lsuA:27.2 | 4ypaC-5lsuA:36.58 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5lsu | HISTONE-LYSINEN-METHYLTRANSFERASENSD2 (Homo sapiens) |
PF00856(SET) | 5 | GLY A1074TRP A1075HIS A1142TYR A1179CYH A1193 | SAM A1304 ( 3.2A)NoneSAM A1304 (-4.6A)SAM A1304 (-4.1A) ZN A1301 (-2.3A) | 1.20A | 4ypaC-5lsuA:27.2 | 4ypaC-5lsuA:36.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nyy | NON-SPECIFICSERINE/THREONINEPROTEIN KINASE (Thermomonosporacurvata) |
PF03781(FGE-sulfatase) | 5 | GLY A 206HIS A 185ASN A 226GLN A 191CYH A 269 | NoneNoneNone CA A 406 ( 4.2A) CD A 401 (-2.4A) | 1.22A | 4ypaC-5nyyA:undetectable | 4ypaC-5nyyA:18.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nyy | NON-SPECIFICSERINE/THREONINEPROTEIN KINASE (Thermomonosporacurvata) |
PF03781(FGE-sulfatase) | 5 | HIS A 185ASN A 226GLN A 191CYH A 269ILE A 189 | NoneNone CA A 406 ( 4.2A) CD A 401 (-2.4A)None | 1.08A | 4ypaC-5nyyA:undetectable | 4ypaC-5nyyA:18.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5teg | N-LYSINEMETHYLTRANSFERASEKMT5A (Homo sapiens) |
PF00856(SET) | 5 | LYS A 226GLY A 227ASN A 298HIS A 299TYR A 336 | SAM A 401 (-4.6A)SAM A 401 ( 4.0A)SAM A 401 (-3.2A)NoneSAM A 401 (-4.8A) | 0.16A | 4ypaC-5tegA:14.5 | 4ypaC-5tegA:23.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5teg | N-LYSINEMETHYLTRANSFERASEKMT5A (Homo sapiens) |
PF00856(SET) | 5 | LYS A 226GLY A 227HIS A 347ASN A 298TYR A 336 | SAM A 401 (-4.6A)SAM A 401 ( 4.0A)NoneSAM A 401 (-3.2A)SAM A 401 (-4.8A) | 1.27A | 4ypaC-5tegA:14.5 | 4ypaC-5tegA:23.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tuy | HISTONE-LYSINEN-METHYLTRANSFERASEEHMT2 (Homo sapiens) |
PF00856(SET)PF05033(Pre-SET) | 5 | GLY A1049TRP A1050ASN A1112HIS A1113CYH A1170 | SAM A1505 ( 3.9A)NoneSAM A1505 (-3.4A)SAM A1505 (-4.7A) ZN A1504 (-2.2A) | 1.15A | 4ypaC-5tuyA:18.6 | 4ypaC-5tuyA:28.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tuy | HISTONE-LYSINEN-METHYLTRANSFERASEEHMT2 (Homo sapiens) |
PF00856(SET)PF05033(Pre-SET) | 6 | GLY A1049TRP A1050ASN A1112HIS A1113TYR A1154CYH A1168 | SAM A1505 ( 3.9A)NoneSAM A1505 (-3.4A)SAM A1505 (-4.7A)SAM A1505 (-4.9A) ZN A1504 (-2.2A) | 0.37A | 4ypaC-5tuyA:18.6 | 4ypaC-5tuyA:28.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vsd | HISTONE-LYSINEN-METHYLTRANSFERASEEHMT1 (Homo sapiens) |
PF00856(SET)PF05033(Pre-SET) | 6 | GLY A1137TRP A1138ASN A1200HIS A1201TYR A1242CYH A1256 | SAM A3001 (-3.6A)NoneSAM A3001 (-3.4A)SAM A3001 (-4.6A)SAM A3001 (-4.8A) ZN A3005 ( 2.4A) | 0.46A | 4ypaC-5vsdA:18.9 | 4ypaC-5vsdA:29.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vsd | HISTONE-LYSINEN-METHYLTRANSFERASEEHMT1 (Homo sapiens) |
PF00856(SET)PF05033(Pre-SET) | 5 | GLY A1137TRP A1138HIS A1201TYR A1242CYH A1258 | SAM A3001 (-3.6A)NoneSAM A3001 (-4.6A)SAM A3001 (-4.8A) ZN A3005 (-2.3A) | 1.20A | 4ypaC-5vsdA:18.9 | 4ypaC-5vsdA:29.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wg6 | HISTONE-LYSINEN-METHYLTRANSFERASEEZH2,POLYCOMBPROTEIN SUZ12(E.C.2.1.1.43)CHIMERA (Homo sapiens) |
no annotation | 5 | GLY A 623TRP A 624ASN A 688HIS A 689TYR A 726 | A9G A9009 ( 4.2A)NoneA9G A9009 (-3.1A)NoneNone | 0.65A | 4ypaC-5wg6A:19.7 | 4ypaC-5wg6A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xxg | - (-) |
no annotation | 5 | GLY A 15ASN A 205HIS A 206TYR A 239CYH A 261 | SAM A 502 ( 3.9A)SAM A 502 (-3.1A)None8HR A 501 ( 4.0A) ZN A 503 (-2.2A) | 0.68A | 4ypaC-5xxgA:6.3 | 4ypaC-5xxgA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c8s | LOGANIC ACIDO-METHYLTRANSFERASE (Catharanthusroseus) |
no annotation | 5 | LYS A 39GLY A 40ASN A 83TYR A 31GLN A 316 | NoneNoneSAH A 401 (-3.8A)SAH A 401 (-4.5A)None | 1.41A | 4ypaC-6c8sA:undetectable | 4ypaC-6c8sA:undetectable | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6cen | HISTONE-LYSINEN-METHYLTRANSFERASENSD3 (Homo sapiens) |
no annotation | 6 | GLY A1156TRP A1157ASN A1223HIS A1224TYR A1261CYH A1273 | SAM A1301 (-3.6A)NoneSAM A1301 (-3.2A)NoneSAM A1301 (-4.9A) ZN A1304 ( 2.3A) | 0.27A | 4ypaC-6cenA:26.4 | 4ypaC-6cenA:41.03 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6cen | HISTONE-LYSINEN-METHYLTRANSFERASENSD3 (Homo sapiens) |
no annotation | 5 | GLY A1156TRP A1157HIS A1224TYR A1261CYH A1275 | SAM A1301 (-3.6A)NoneNoneSAM A1301 (-4.9A) ZN A1304 (-2.3A) | 1.29A | 4ypaC-6cenA:26.4 | 4ypaC-6cenA:41.03 |