SIMILAR PATTERNS OF AMINO ACIDS FOR 4YP2_B_NCAB302

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1abr ABRIN-A

(Abrus
precatorius) 		PF00161
(RIP) 		7 TYR A  74
GLY A 111
TYR A 113
ILE A 159
ALA A 163
GLU A 164
ARG A 167
 None
 0.57A 4yp2B-1abrA:
33.6		 4yp2B-1abrA:
34.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1abr ABRIN-A

(Abrus
precatorius) 		PF00161
(RIP) 		5 TYR A  74
ILE A  68
ALA A 163
GLU A 164
ARG A 167
 None
 1.38A 4yp2B-1abrA:
33.6		 4yp2B-1abrA:
34.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1aha ALPHA-MOMORCHARIN

(Momordica
charantia) 		PF00161
(RIP) 		9 TYR A  70
ILE A  71
PHE A  83
GLY A 109
TYR A 111
ILE A 155
ALA A 159
GLU A 160
ARG A 163
 ADE  A 339 ( 3.8A)
ADE  A 339 (-3.9A)
ADE  A 339 ( 4.8A)
ADE  A 339 (-4.1A)
ADE  A 339 ( 3.6A)
ADE  A 339 (-4.1A)
ADE  A 339 ( 3.7A)
ADE  A 339 (-4.5A)
ADE  A 339 ( 2.9A)
 0.29A 4yp2B-1ahaA:
43.8		 4yp2B-1ahaA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1apa POKEWEED ANTIVIRAL
PROTEIN

(Phytolacca
americana) 		PF00161
(RIP) 		6 TYR A  77
PHE A  94
TYR A 128
ILE A 175
GLU A 180
ARG A 183
 None
 0.65A 4yp2B-1apaA:
30.7		 4yp2B-1apaA:
30.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ayy GLYCOSYLASPARAGINASE

(Elizabethkingia
meningoseptica) 		PF01112
(Asparaginase_2) 		5 ILE B 186
GLY B 190
ILE B 210
GLU B 207
ARG B 180
 None
 1.14A 4yp2B-1ayyB:
undetectable		 4yp2B-1ayyB:
22.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bry BRYODIN I

(Bryonia dioica) 		PF00161
(RIP) 		9 TYR Y  70
ILE Y  71
PHE Y  83
GLY Y 109
TYR Y 111
ILE Y 155
ALA Y 159
GLU Y 160
ARG Y 163
 None
 0.59A 4yp2B-1bryY:
41.6		 4yp2B-1bryY:
67.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ce7 PROTEIN
(RIBOSOME-INACTIVATI
NG PROTEIN TYPE II)

(Viscum album) 		PF00161
(RIP) 		6 TYR A  75
GLY A 109
TYR A 111
ILE A 155
GLU A 160
ARG A 163
 None
 0.88A 4yp2B-1ce7A:
31.9		 4yp2B-1ce7A:
35.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cf5 PROTEIN
(BETA-MOMORCHARIN)

(Momordica
charantia) 		PF00161
(RIP) 		8 TYR A  70
PHE A  83
GLY A 107
TYR A 109
ILE A 153
ALA A 157
GLU A 158
ARG A 161
 None
 0.57A 4yp2B-1cf5A:
38.3		 4yp2B-1cf5A:
54.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE

(Shewanella
oneidensis) 		PF00890
(FAD_binding_2)
PF14537
(Cytochrom_c3_2) 		5 ILE A 408
PHE A 394
TYR A 417
ALA A 499
GLU A 497
 None
 1.25A 4yp2B-1d4eA:
undetectable		 4yp2B-1d4eA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dm0 SHIGA TOXIN A
SUBUNIT

(Shigella
dysenteriae) 		PF00161
(RIP) 		5 PHE A  92
TYR A 114
ALA A 166
GLU A 167
ARG A 170
 None
 0.55A 4yp2B-1dm0A:
22.1		 4yp2B-1dm0A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dq3 ENDONUCLEASE

(Pyrococcus
furiosus) 		PF09061
(Stirrup)
PF09062
(Endonuc_subdom)
PF14528
(LAGLIDADG_3)
PF14890
(Intein_splicing) 		5 ILE A  93
PHE A 101
TYR A 442
ILE A   2
ALA A   6
 None
 1.30A 4yp2B-1dq3A:
undetectable		 4yp2B-1dq3A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fft UBIQUINOL OXIDASE

(Escherichia
coli) 		PF00115
(COX1) 		5 TYR A  61
ILE A  63
GLY A  58
ILE A  62
ALA A  65
 None
 1.37A 4yp2B-1fftA:
undetectable		 4yp2B-1fftA:
15.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hwn EBULIN

(Sambucus ebulus) 		PF00161
(RIP) 		6 TYR A  77
GLY A 114
TYR A 116
ILE A 158
GLU A 163
ARG A 166
 None
 0.77A 4yp2B-1hwnA:
32.6		 4yp2B-1hwnA:
37.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hwn EBULIN

(Sambucus ebulus) 		PF00161
(RIP) 		6 TYR A  77
PHE A  90
GLY A 114
TYR A 116
ILE A 158
ARG A 166
 None
 0.75A 4yp2B-1hwnA:
32.6		 4yp2B-1hwnA:
37.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l8w VLSE1

(Borreliella
burgdorferi) 		PF00921
(Lipoprotein_2) 		5 ILE A 284
PHE A 202
GLY A 199
ILE A 280
ALA A 222
 None
 1.27A 4yp2B-1l8wA:
undetectable		 4yp2B-1l8wA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpc DIANTHIN 30

(Dianthus
caryophyllus) 		PF00161
(RIP) 		7 TYR A  73
PHE A  91
TYR A 121
ILE A 172
ALA A 176
GLU A 177
ARG A 180
 CMP  A 901 (-4.1A)
None
CMP  A 901 (-4.3A)
CMP  A 901 (-4.1A)
CMP  A 901 ( 4.0A)
CMP  A 901 (-3.9A)
CMP  A 901 (-3.0A)
 0.58A 4yp2B-1lpcA:
27.7		 4yp2B-1lpcA:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mab PROTEIN (F1-ATPASE
BETA CHAIN)

(Rattus
norvegicus) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		5 TYR B 311
ILE B 310
GLY B 156
GLU B 188
ARG B 260
 None
None
None
PO4  B 601 (-3.1A)
None
 1.38A 4yp2B-1mabB:
undetectable		 4yp2B-1mabB:
19.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nio B-LUFFIN

(Luffa
aegyptiaca) 		PF00161
(RIP) 		9 TYR A  71
ILE A  72
PHE A  84
GLY A 109
TYR A 111
ILE A 155
ALA A 159
GLU A 160
ARG A 163
 None
 0.37A 4yp2B-1nioA:
41.0		 4yp2B-1nioA:
70.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5o URACIL
PHOSPHORIBOSYLTRANSF
ERASE

(Thermotoga
maritima) 		PF14681
(UPRTase) 		5 TYR A 193
ILE A 194
GLY A 199
ALA A 135
ARG A 104
 U5P  A 600 (-4.4A)
U5P  A 600 (-4.0A)
None
U5P  A 600 (-3.4A)
U5P  A 600 (-3.4A)
 0.93A 4yp2B-1o5oA:
undetectable		 4yp2B-1o5oA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pn4 PEROXISOMAL
HYDRATASE-DEHYDROGEN
ASE-EPIMERASE

(Candida
tropicalis) 		PF01575
(MaoC_dehydratas) 		5 ILE A  91
PHE A   9
GLY A  89
ILE A 124
GLU A 122
 None
 1.33A 4yp2B-1pn4A:
undetectable		 4yp2B-1pn4A:
22.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qcj POKEWEED ANTIVIRAL
PROTEIN

(Phytolacca
americana) 		PF00161
(RIP) 		6 TYR A  72
PHE A  90
TYR A 123
ILE A 171
GLU A 176
ARG A 179
 APT  A 901 (-3.9A)
APT  A 901 ( 4.7A)
APT  A 901 (-4.7A)
APT  A 901 (-3.7A)
APT  A 901 ( 3.6A)
APT  A 901 (-3.0A)
 0.59A 4yp2B-1qcjA:
31.0		 4yp2B-1qcjA:
30.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qi7 PROTEIN
(N-GLYCOSIDASE)

(Saponaria
officinalis) 		PF00161
(RIP) 		5 PHE A  90
TYR A 120
ILE A 171
GLU A 176
ARG A 179
 None
 0.71A 4yp2B-1qi7A:
22.0		 4yp2B-1qi7A:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qi7 PROTEIN
(N-GLYCOSIDASE)

(Saponaria
officinalis) 		PF00161
(RIP) 		5 TYR A 120
ILE A 171
ALA A 175
GLU A 176
ARG A 179
 None
 0.29A 4yp2B-1qi7A:
22.0		 4yp2B-1qi7A:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4p SHIGA-LIKE TOXIN
TYPE II A SUBUNIT

(Escherichia
coli) 		PF00161
(RIP) 		5 PHE A  92
TYR A 114
ALA A 166
GLU A 167
ARG A 170
 FMT  A3015 ( 4.9A)
FMT  A3015 ( 4.1A)
FMT  A3015 ( 4.9A)
None
None
 0.42A 4yp2B-1r4pA:
22.3		 4yp2B-1r4pA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4p SHIGA-LIKE TOXIN
TYPE II A SUBUNIT

(Escherichia
coli) 		PF00161
(RIP) 		5 TYR A  77
TYR A 114
ALA A 166
GLU A 167
ARG A 170
 FMT  A3015 (-4.7A)
FMT  A3015 ( 4.1A)
FMT  A3015 ( 4.9A)
None
None
 0.52A 4yp2B-1r4pA:
22.3		 4yp2B-1r4pA:
23.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tcs TRICHOSANTHIN

(Trichosanthes
kirilowii) 		PF00161
(RIP) 		7 ILE A  71
PHE A  83
GLY A 109
TYR A 111
ILE A 155
GLU A 160
ARG A 163
 NDP  A 280 (-4.5A)
NDP  A 280 ( 4.8A)
NDP  A 280 (-3.9A)
NDP  A 280 ( 3.7A)
NDP  A 280 (-3.9A)
NDP  A 280 ( 2.7A)
NDP  A 280 ( 2.6A)
 0.23A 4yp2B-1tcsA:
40.4		 4yp2B-1tcsA:
65.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tcs TRICHOSANTHIN

(Trichosanthes
kirilowii) 		PF00161
(RIP) 		7 TYR A  70
ILE A  71
PHE A  83
GLY A 109
ILE A 155
GLU A 160
ARG A 163
 NDP  A 280 ( 4.7A)
NDP  A 280 (-4.5A)
NDP  A 280 ( 4.8A)
NDP  A 280 (-3.9A)
NDP  A 280 (-3.9A)
NDP  A 280 ( 2.7A)
NDP  A 280 ( 2.6A)
 0.61A 4yp2B-1tcsA:
40.4		 4yp2B-1tcsA:
65.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1woq INORGANIC
POLYPHOSPHATE/ATP-GL
UCOMANNOKINASE

(Arthrobacter
sp. KM) 		PF00480
(ROK) 		5 ILE A  15
GLY A  26
ILE A  28
ALA A  71
GLU A  70
 None
 1.13A 4yp2B-1woqA:
undetectable		 4yp2B-1woqA:
22.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1yf8 BETA-GALACTOSIDE-SPE
CIFIC LECTIN 4

(Viscum album) 		PF00161
(RIP) 		5 TYR A  75
GLY A 108
ILE A 154
GLU A 159
ARG A 162
 P6C  A1001 (-4.6A)
None
None
P6C  A1001 ( 4.4A)
P6C  A1001 (-2.6A)
 0.95A 4yp2B-1yf8A:
31.7		 4yp2B-1yf8A:
34.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eae ALPHA-FUCOSIDASE

(Bifidobacterium
bifidum) 		PF14498
(Glyco_hyd_65N_2) 		5 ILE A 277
GLY A  60
ILE A  58
ALA A 279
GLU A  75
 None
 1.28A 4yp2B-2eaeA:
undetectable		 4yp2B-2eaeA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g5x RIBOSOME-INACTIVATIN
G PROTEIN

(Silene
chalcedonica) 		PF00161
(RIP) 		6 PHE A  88
TYR A 119
ILE A 165
ALA A 169
GLU A 170
ARG A 173
 None
 0.56A 4yp2B-2g5xA:
21.9		 4yp2B-2g5xA:
29.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inp PHENOL HYDROXYLASE
COMPONENT PHL

(Pseudomonas
stutzeri) 		PF02332
(Phenol_Hydrox) 		5 ILE C 222
GLY C 224
ALA C 133
GLU C 130
ARG C 160
 None
 1.28A 4yp2B-2inpC:
undetectable		 4yp2B-2inpC:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iy8 PROTEIN PM0188

(Pasteurella
multocida) 		PF11477
(PM0188) 		5 ILE A 184
TYR A 217
ILE A 161
ALA A 164
GLU A 165
 None
 1.28A 4yp2B-2iy8A:
undetectable		 4yp2B-2iy8A:
20.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2oqa LUFFACULIN 1

(Luffa
acutangula) 		PF00161
(RIP) 		9 TYR A  70
ILE A  71
PHE A  83
GLY A 108
TYR A 110
ILE A 154
ALA A 158
GLU A 159
ARG A 162
 None
 0.46A 4yp2B-2oqaA:
40.7		 4yp2B-2oqaA:
71.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppv UNCHARACTERIZED
PROTEIN

(Staphylococcus
epidermidis) 		PF01933
(UPF0052) 		5 ILE A 200
ILE A 171
ALA A 203
GLU A 175
ARG A 206
 None
 1.32A 4yp2B-2ppvA:
undetectable		 4yp2B-2ppvA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pqi RIBOSOME-INACTIVATIN
G PROTEIN 3

(Zea mays) 		PF00161
(RIP) 		5 PHE A 108
GLY A 128
TYR A 130
GLU A 207
ARG A 210
 None
 0.41A 4yp2B-2pqiA:
24.5		 4yp2B-2pqiA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2psf RENILLA-LUCIFERIN
2-MONOOXYGENASE

(Renilla
reniformis) 		PF00561
(Abhydrolase_1) 		5 ILE A  15
GLY A  17
TYR A 202
GLU A 289
ARG A 192
 None
 1.25A 4yp2B-2psfA:
undetectable		 4yp2B-2psfA:
21.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q8w POKEWEED ANTIVIRAL
PROTEIN

(Phytolacca
acinosa) 		PF00161
(RIP) 		6 PHE A  89
GLY A 120
TYR A 122
ILE A 170
GLU A 175
ARG A 178
 None
 0.45A 4yp2B-2q8wA:
31.1		 4yp2B-2q8wA:
31.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q8w POKEWEED ANTIVIRAL
PROTEIN

(Phytolacca
acinosa) 		PF00161
(RIP) 		6 TYR A  72
PHE A  89
TYR A 122
ILE A 170
GLU A 175
ARG A 178
 None
 0.60A 4yp2B-2q8wA:
31.1		 4yp2B-2q8wA:
31.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qes RIBOSOME-INACTIVATIN
G PROTEIN PD-L4

(Phytolacca
dioica) 		PF00161
(RIP) 		6 TYR A  72
PHE A  89
TYR A 122
ILE A 170
GLU A 175
ARG A 178
 ADE  A 501 (-3.8A)
ADE  A 501 ( 4.9A)
ADE  A 501 (-3.7A)
ADE  A 501 (-4.0A)
ADE  A 501 ( 4.7A)
ADE  A 501 (-2.9A)
 0.24A 4yp2B-2qesA:
31.2		 4yp2B-2qesA:
31.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qw5 XYLOSE
ISOMERASE-LIKE TIM
BARREL

(Trichormus
variabilis) 		PF01261
(AP_endonuc_2) 		5 GLY A 127
TYR A 133
ILE A 184
GLU A 188
ARG A 252
 XLS  A 401 ( 4.7A)
XLS  A 401 ( 3.8A)
XLS  A 401 ( 4.3A)
XLS  A 401 (-3.2A)
XLS  A 401 ( 4.0A)
 1.01A 4yp2B-2qw5A:
undetectable		 4yp2B-2qw5A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r37 GLUTATHIONE
PEROXIDASE 3

(Homo sapiens) 		PF00255
(GSHPx) 		5 TYR A  53
ILE A  54
PHE A  56
GLY A  44
GLU A 136
 None
 1.22A 4yp2B-2r37A:
undetectable		 4yp2B-2r37A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rg2 CHOLOYLGLYCINE
HYDROLASE

(Clostridium
perfringens) 		PF02275
(CBAH) 		5 ILE A  33
PHE A  67
GLY A  56
TYR A 317
GLU A 307
 None
 1.24A 4yp2B-2rg2A:
undetectable		 4yp2B-2rg2A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vlc TYPE 2
RIBOSOME-INACTIVATIN
G PROTEIN CINNAMOMIN
III

(Cinnamomum
camphora) 		PF00161
(RIP)
PF00652
(Ricin_B_lectin) 		6 GLY A 113
TYR A 115
ILE A 162
ALA A 166
GLU A 167
ARG A 170
 None
 0.29A 4yp2B-2vlcA:
30.9		 4yp2B-2vlcA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vlc TYPE 2
RIBOSOME-INACTIVATIN
G PROTEIN CINNAMOMIN
III

(Cinnamomum
camphora) 		PF00161
(RIP)
PF00652
(Ricin_B_lectin) 		5 TYR A  75
GLY A 113
ILE A 162
ALA A 166
ARG A 170
 None
 0.77A 4yp2B-2vlcA:
30.9		 4yp2B-2vlcA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major) 		PF03738
(GSP_synth)
PF05257
(CHAP) 		5 ILE A 598
PHE A 272
ILE A 612
ALA A 596
GLU A 614
 None
 1.29A 4yp2B-2vobA:
undetectable		 4yp2B-2vobA:
16.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zr1 AGGLUTININ-1 CHAIN A

(Abrus
precatorius) 		PF00161
(RIP) 		8 TYR A  73
PHE A  86
GLY A 110
TYR A 112
ILE A 158
ALA A 162
GLU A 163
ARG A 166
 None
 0.43A 4yp2B-2zr1A:
24.7		 4yp2B-2zr1A:
33.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zws NEUTRAL CERAMIDASE

(Pseudomonas
aeruginosa) 		PF04734
(Ceramidase_alk)
PF17048
(Ceramidse_alk_C) 		5 ILE A  14
GLY A  16
ALA A  12
GLU A 556
ARG A 132
 None
 1.38A 4yp2B-2zwsA:
undetectable		 4yp2B-2zwsA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3asi NEUREXIN-1-ALPHA

(Bos taurus) 		PF02210
(Laminin_G_2) 		5 ILE A1098
PHE A1091
GLY A1096
ILE A1253
ALA A1252
 None
 1.38A 4yp2B-3asiA:
undetectable		 4yp2B-3asiA:
21.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3bwh CUCURMOSIN

(Cucurbita
moschata) 		PF00161
(RIP) 		8 TYR A  70
ILE A  71
PHE A  83
GLY A 107
TYR A 109
ILE A 153
GLU A 158
ARG A 161
 EDO  A 253 ( 4.5A)
None
None
EDO  A 253 (-4.5A)
EDO  A 253 ( 4.1A)
EDO  A 253 ( 4.1A)
EDO  A 253 ( 4.6A)
EDO  A 253 (-2.9A)
 0.48A 4yp2B-3bwhA:
39.4		 4yp2B-3bwhA:
58.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctk RRNA N-GLYCOSIDASE

(Bougainvillea
spectabilis) 		PF00161
(RIP) 		5 GLY A 112
TYR A 114
ILE A 160
GLU A 165
ARG A 168
 None
 0.25A 4yp2B-3ctkA:
33.3		 4yp2B-3ctkA:
29.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctk RRNA N-GLYCOSIDASE

(Bougainvillea
spectabilis) 		PF00161
(RIP) 		5 TYR A  70
GLY A 112
ILE A 160
GLU A 165
ARG A 168
 None
 0.73A 4yp2B-3ctkA:
33.3		 4yp2B-3ctkA:
29.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehm SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12741
(SusD-like) 		5 ILE A 104
GLY A  24
ILE A 119
ALA A 108
GLU A 116
 None
 0.94A 4yp2B-3ehmA:
undetectable		 4yp2B-3ehmA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg2 PUTATIVE RUBREDOXIN
REDUCTASE

(Rhodopseudomonas
palustris) 		PF07992
(Pyr_redox_2)
PF14759
(Reductase_C) 		5 ILE P  32
ILE P  75
ALA P  30
GLU P  73
ARG P  28
 FAD  P 449 ( 4.5A)
None
None
None
None
 0.95A 4yp2B-3fg2P:
undetectable		 4yp2B-3fg2P:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5k RIBOSOME-INACTIVATIN
G PROTEIN
PD-L1/PD-L2

(Phytolacca
dioica) 		PF00161
(RIP) 		6 TYR A  72
PHE A  89
TYR A 122
ILE A 170
GLU A 175
ARG A 178
 EDO  A 264 ( 4.9A)
None
EDO  A 264 (-3.5A)
EDO  A 264 (-4.0A)
None
None
 0.42A 4yp2B-3h5kA:
22.6		 4yp2B-3h5kA:
29.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hiw VACUOLAR SAPORIN

(Saponaria
officinalis) 		PF00161
(RIP) 		5 TYR A  73
PHE A  91
TYR A 123
GLU A 174
ARG A 177
 C2X  A 260 (-3.4A)
C2X  A 260 ( 4.6A)
C2X  A 260 (-3.7A)
C2X  A 260 (-3.0A)
C2X  A 260 (-2.9A)
 0.36A 4yp2B-3hiwA:
27.5		 4yp2B-3hiwA:
29.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iv3 TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2

(Streptococcus
mutans) 		PF01791
(DeoC) 		5 TYR A 145
ILE A 146
TYR A  91
ILE A 149
GLU A 152
 EDO  A 336 (-4.1A)
None
None
None
None
 1.07A 4yp2B-3iv3A:
undetectable		 4yp2B-3iv3A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3izy TRANSLATION
INITIATION FACTOR
IF-2, MITOCHONDRIAL

(Bos taurus) 		PF00009
(GTP_EFTU)
PF11987
(IF-2) 		5 TYR P 572
ILE P 519
GLY P 573
ILE P 571
ALA P 564
 None
 1.24A 4yp2B-3izyP:
undetectable		 4yp2B-3izyP:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb8 COAT PROTEIN

(Maize chlorotic
mottle virus) 		PF00729
(Viral_coat) 		5 TYR A 121
ILE A 122
GLY A 120
ILE A 197
ALA A 196
 None
 1.07A 4yp2B-3jb8A:
undetectable		 4yp2B-3jb8A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jrk TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2

(Streptococcus
pyogenes) 		PF01791
(DeoC) 		5 TYR A 141
ILE A 142
TYR A  87
ILE A 145
GLU A 148
 None
 1.10A 4yp2B-3jrkA:
undetectable		 4yp2B-3jrkA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kao TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE

(Staphylococcus
aureus) 		PF01791
(DeoC) 		5 TYR A 145
ILE A 146
TYR A  91
ILE A 149
GLU A 152
 None
 1.07A 4yp2B-3kaoA:
undetectable		 4yp2B-3kaoA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kes NUCLEOPORIN NUP145

(Saccharomyces
cerevisiae) 		PF04096
(Nucleoporin2) 		5 ILE A 494
PHE A 520
GLY A 492
ILE A 548
ALA A 546
 None
None
EDO  A   4 ( 4.8A)
None
None
 1.33A 4yp2B-3kesA:
undetectable		 4yp2B-3kesA:
22.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ku0 RIBOSOME-INACTIVATIN
G PROTEIN GELONIN

(Suregada
multiflora) 		PF00161
(RIP) 		6 PHE A  87
GLY A 111
TYR A 113
ILE A 161
GLU A 166
ARG A 169
 ADE  A 800 (-4.6A)
ADE  A 800 (-4.1A)
ADE  A 800 (-3.5A)
ADE  A 800 (-4.0A)
ADE  A 800 ( 4.5A)
ADE  A 800 (-2.7A)
 0.23A 4yp2B-3ku0A:
33.9		 4yp2B-3ku0A:
34.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mvg RIBOSOME
INACTIVATING TYPE 1
PROTEIN

(Iris x
hollandica) 		PF00161
(RIP) 		5 GLY A 106
TYR A 108
ILE A 156
GLU A 161
ARG A 164
 GOL  A 284 ( 4.9A)
GOL  A 281 (-4.4A)
None
None
GOL  A 284 (-3.1A)
 0.50A 4yp2B-3mvgA:
25.3		 4yp2B-3mvgA:
32.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mw2 NEUREXIN-1-ALPHA

(Mus musculus) 		PF02210
(Laminin_G_2) 		5 ILE A  96
PHE A  89
GLY A  94
ILE A 281
ALA A 280
 None
 1.36A 4yp2B-3mw2A:
undetectable		 4yp2B-3mw2A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myo TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 1

(Streptococcus
pyogenes) 		PF01791
(DeoC) 		5 TYR A 144
ILE A 145
TYR A  90
ILE A 148
GLU A 151
 None
 1.09A 4yp2B-3myoA:
undetectable		 4yp2B-3myoA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nf5 NUCLEOPORIN NUP116

([Candida]
glabrata) 		PF04096
(Nucleoporin2) 		5 ILE A 927
PHE A 950
GLY A 925
ILE A 977
ALA A 975
 None
 1.29A 4yp2B-3nf5A:
undetectable		 4yp2B-3nf5A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p1u SUSD HOMOLOG

(Parabacteroides
distasonis) 		PF12741
(SusD-like) 		5 ILE A 230
GLY A 393
TYR A 390
ILE A 395
ALA A 233
 None
 0.98A 4yp2B-3p1uA:
undetectable		 4yp2B-3p1uA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pbp NUCLEOPORIN
NUP116/NSP116

(Saccharomyces
cerevisiae) 		PF04096
(Nucleoporin2) 		5 ILE B1003
PHE B1026
GLY B1001
ILE B1053
ALA B1051
 None
 1.33A 4yp2B-3pbpB:
undetectable		 4yp2B-3pbpB:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qcw NEUREXIN-1-ALPHA

(Bos taurus) 		PF00008
(EGF)
PF02210
(Laminin_G_2) 		5 ILE A1142
PHE A1135
GLY A1140
ILE A1327
ALA A1326
 None
 1.36A 4yp2B-3qcwA:
undetectable		 4yp2B-3qcwA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qvm OLEI00960

(Oleispira
antarctica) 		PF00561
(Abhydrolase_1) 		5 ILE A 113
GLY A  82
TYR A  61
ILE A 110
ALA A 111
 None
 1.02A 4yp2B-3qvmA:
undetectable		 4yp2B-3qvmA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tfo PUTATIVE
3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE

(Sinorhizobium
meliloti) 		PF00106
(adh_short) 		5 ILE A  41
GLY A  14
ILE A  44
ALA A  43
GLU A  47
 None
 0.90A 4yp2B-3tfoA:
undetectable		 4yp2B-3tfoA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tov GLYCOSYL TRANSFERASE
FAMILY 9

(Veillonella
parvula) 		PF01075
(Glyco_transf_9) 		5 TYR A 215
GLY A 211
TYR A 209
ALA A 338
GLU A 339
 None
 1.36A 4yp2B-3tovA:
undetectable		 4yp2B-3tovA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w2z METHYL-ACCEPTING
CHEMOTAXIS PROTEIN

(Nostoc sp. PCC
7120) 		PF01590
(GAF) 		5 ILE A  36
PHE A  40
ILE A 180
ALA A 183
GLU A 184
 None
 1.33A 4yp2B-3w2zA:
undetectable		 4yp2B-3w2zA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wks O-PHOSPHO-L-SERYL-TR
NA:CYS-TRNA SYNTHASE

(Methanocaldococcus
jannaschii) 		PF05889
(SepSecS) 		5 TYR A 159
ILE A 163
GLY A 158
ILE A 197
ALA A 198
 None
 1.29A 4yp2B-3wksA:
undetectable		 4yp2B-3wksA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ads PYRIDOXINE
BIOSYNTHETIC ENZYME
PDX1 HOMOLOGUE,
PUTATIVE

(Plasmodium
berghei) 		PF01680
(SOR_SNZ) 		5 ILE A  25
PHE A 213
GLY A 234
ILE A  43
ALA A  42
 None
 1.01A 4yp2B-4adsA:
undetectable		 4yp2B-4adsA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h59 IRON-COMPOUND ABC
TRANSPORTER, IRON
COMPOUND-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF01497
(Peripla_BP_2) 		5 ILE A 121
PHE A 110
GLY A  78
ILE A 129
ALA A 148
 None
 1.30A 4yp2B-4h59A:
undetectable		 4yp2B-4h59A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN

(Lactobacillus
acidophilus) 		PF06100
(MCRA) 		5 GLY A 443
TYR A 421
ILE A 449
ALA A 453
GLU A 436
 None
 1.39A 4yp2B-4ia5A:
undetectable		 4yp2B-4ia5A:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ijm CIRCADIAN CLOCK
PROTEIN KINASE KAIC

(Synechococcus
elongatus) 		PF06745
(ATPase) 		5 ILE A 313
PHE A 315
TYR A 402
ILE A 367
GLU A 406
 None
 1.26A 4yp2B-4ijmA:
undetectable		 4yp2B-4ijmA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imv RICIN

(Ricinus
communis) 		PF00161
(RIP) 		5 PHE A  93
GLY A 121
TYR A 123
ILE A 172
GLU A 177
 None
 0.63A 4yp2B-4imvA:
20.9		 4yp2B-4imvA:
28.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4jkx BETA-GALACTOSIDE-SPE
CIFIC LECTIN 1 A
CHAIN

(Viscum album) 		PF00161
(RIP) 		5 TYR A  76
GLY A 113
ILE A 160
GLU A 165
ARG A 168
 H35  A 305 (-4.2A)
None
H35  A 305 ( 4.5A)
H35  A 305 (-3.5A)
H35  A 305 (-3.3A)
 0.86A 4yp2B-4jkxA:
32.4		 4yp2B-4jkxA:
33.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mll BETA-LACTAMASE OXA-1

(Escherichia
coli) 		PF00905
(Transpeptidase) 		5 ILE A 179
PHE A 232
GLY A 231
ILE A  71
ALA A  72
 None
 1.31A 4yp2B-4mllA:
undetectable		 4yp2B-4mllA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rkm MCCA

(Wolinella
succinogenes) 		no annotation 5 ILE A 679
GLY A 622
TYR A 624
ILE A 644
ALA A 647
 None
 0.97A 4yp2B-4rkmA:
2.0		 4yp2B-4rkmA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u10 POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE

(Aggregatibacter
actinomycetemcomitans) 		PF01522
(Polysacc_deac_1) 		5 ILE A 219
GLY A 224
ILE A 165
ALA A 166
GLU A 164
 None
 1.37A 4yp2B-4u10A:
undetectable		 4yp2B-4u10A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE

(Bacillus
licheniformis) 		PF01019
(G_glu_transpept) 		5 ILE A 228
TYR A 431
ILE A 241
ALA A 235
GLU A 240
 None
 1.17A 4yp2B-4y23A:
undetectable		 4yp2B-4y23A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d55 HDAB,HDAA (ADHESIN),
HUS-ASSOCIATED
DIFFUSE ADHERENCE

(Escherichia
coli) 		PF05775
(AfaD) 		5 ILE A  26
PHE A  94
GLY A  24
ILE A   3
ALA A   1
 None
 1.31A 4yp2B-5d55A:
undetectable		 4yp2B-5d55A:
21.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ddz RICIN

(Ricinus
communis) 		PF00161
(RIP) 		6 PHE A  93
GLY A 121
TYR A 123
ILE A 172
GLU A 177
ARG A 180
 None
 0.40A 4yp2B-5ddzA:
34.4		 4yp2B-5ddzA:
34.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ejs MYOSIN-I HEAVY CHAIN

(Dictyostelium
discoideum) 		PF00373
(FERM_M)
PF00784
(MyTH4)
PF09380
(FERM_C) 		5 ILE A2260
GLY A2264
TYR A2186
ILE A2177
GLU A2180
 None
 1.33A 4yp2B-5ejsA:
undetectable		 4yp2B-5ejsA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fkw DNA POLYMERASE III
EPSILON

(Escherichia
coli) 		PF00929
(RNase_T) 		5 ILE D  90
PHE D  86
ILE D   9
ALA D  93
ARG D   7
 None
 1.21A 4yp2B-5fkwD:
undetectable		 4yp2B-5fkwD:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hjl TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE

(Streptococcus
porcinus) 		PF01791
(DeoC) 		5 TYR A 144
ILE A 145
TYR A  90
ILE A 148
GLU A 151
 None
 1.08A 4yp2B-5hjlA:
undetectable		 4yp2B-5hjlA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ido 3' TERMINAL URIDYLYL
TRANSFERASE

(Trypanosoma
brucei) 		PF03828
(PAP_assoc) 		5 ILE A 311
GLY A 307
ILE A 470
ALA A 276
GLU A 466
 None
 1.38A 4yp2B-5idoA:
undetectable		 4yp2B-5idoA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lae PEROXISOMAL
N(1)-ACETYL-SPERMINE
/SPERMIDINE
OXIDASE,PEROXISOMAL
N(1)-ACETYL-SPERMINE
/SPERMIDINE OXIDASE

(Mus musculus) 		PF01593
(Amino_oxidase) 		5 ILE A 358
PHE A 331
TYR A 127
ILE A 183
GLU A 184
 None
 1.32A 4yp2B-5laeA:
undetectable		 4yp2B-5laeA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lh9 OMEGA TRANSAMINASE

(Pseudomonas sp.) 		PF00202
(Aminotran_3) 		5 ILE A 421
GLY A 418
ILE A 422
ALA A 380
ARG A 373
 None
 1.31A 4yp2B-5lh9A:
undetectable		 4yp2B-5lh9A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mp7 RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE

(Mycolicibacterium
smegmatis) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		5 GLY A  46
ILE A  48
ALA A  40
GLU A  77
ARG A  18
 None
 1.27A 4yp2B-5mp7A:
undetectable		 4yp2B-5mp7A:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tro PENICILLIN-BINDING
PROTEIN 1

(Staphylococcus
aureus) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 ILE A 181
GLY A 198
ILE A  68
ALA A  77
ARG A 169
 None
 1.25A 4yp2B-5troA:
undetectable		 4yp2B-5troA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v2i GLYCOSYLASPARAGINASE

(Elizabethkingia
meningoseptica) 		PF01112
(Asparaginase_2) 		5 ILE A 186
GLY A 190
ILE A 210
GLU A 207
ARG A 180
 None
 1.19A 4yp2B-5v2iA:
undetectable		 4yp2B-5v2iA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtc NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
10
NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
11, MITOCHONDRIAL

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		5 ILE d  96
TYR d  10
ILE d  99
ALA e 122
GLU e 123
 None
 1.37A 4yp2B-5xtcd:
undetectable		 4yp2B-5xtcd:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxf PROTECTION OF
TELOMERES PROTEIN
POZ1

(Schizosaccharomyces
pombe) 		no annotation 5 ILE A  54
PHE A 235
TYR A 219
ILE A 106
GLU A 107
 None
 1.26A 4yp2B-5xxfA:
undetectable		 4yp2B-5xxfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ydg MULTIPLE ORGANELLAR
RNA EDITING FACTOR
2, CHLOROPLASTIC

(Arabidopsis
thaliana) 		no annotation 5 ILE A 126
PHE A 176
GLY A 179
ILE A 109
GLU A 119
 None
 1.23A 4yp2B-5ydgA:
undetectable		 4yp2B-5ydgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ydg MULTIPLE ORGANELLAR
RNA EDITING FACTOR
2, CHLOROPLASTIC

(Arabidopsis
thaliana) 		no annotation 5 PHE A 176
GLY A 179
ILE A 109
ALA A 113
GLU A 119
 None
 1.21A 4yp2B-5ydgA:
undetectable		 4yp2B-5ydgA:
undetectable