SIMILAR PATTERNS OF AMINO ACIDS FOR 4YOA_A_017A100

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cmx PROTEIN (UBIQUITIN
YUH1-UBAL)

(Saccharomyces
cerevisiae) 		PF01088
(Peptidase_C12) 		4 ASN A 101
ASP A  78
THR A 169
VAL A 171
 None
 1.08A 4yoaA-1cmxA:
undetectable		 4yoaA-1cmxA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1k ADRENODOXIN
REDUCTASE

(Bos taurus) 		PF07992
(Pyr_redox_2) 		4 ASP A 319
THR A 314
PRO A 313
THR A 300
 None
 1.14A 4yoaA-1e1kA:
0.0		 4yoaA-1e1kA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ex0 COAGULATION FACTOR
XIII A CHAIN

(Homo sapiens) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		4 ASN A 337
ASP A 396
THR A 480
THR A 478
 None
 1.10A 4yoaA-1ex0A:
undetectable		 4yoaA-1ex0A:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fzq ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
3

(Mus musculus) 		PF00025
(Arf) 		4 ASP A  26
THR A  46
PRO A  47
THR A  48
 None
 1.04A 4yoaA-1fzqA:
0.0		 4yoaA-1fzqA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ig0 THIAMIN
PYROPHOSPHOKINASE

(Saccharomyces
cerevisiae) 		PF04263
(TPK_catalytic)
PF04265
(TPK_B1_binding) 		5 ASP A 271
THR A 277
PRO A 255
THR A 260
VAL A 262
 None
 1.49A 4yoaA-1ig0A:
undetectable		 4yoaA-1ig0A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mpp PEPSIN

(Rhizomucor
pusillus) 		PF00026
(Asp) 		4 ASN A 134
ASP A 127
PRO A 149
VAL A 138
 SO4  A 501 (-3.9A)
None
None
None
 1.15A 4yoaA-1mppA:
6.4		 4yoaA-1mppA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q0u BSTDEAD

(Geobacillus
stearothermophilus) 		PF00270
(DEAD) 		4 ASP A 147
PRO A 134
THR A  78
VAL A  76
 None
 1.04A 4yoaA-1q0uA:
0.0		 4yoaA-1q0uA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3s THERMOSOME ALPHA
SUBUNIT

(Thermococcus
sp. JCM 11816) 		PF00118
(Cpn60_TCP1) 		4 ASP A 278
THR A 286
PRO A 341
THR A 340
 None
 1.09A 4yoaA-1q3sA:
undetectable		 4yoaA-1q3sA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q9j POLYKETIDE SYNTHASE
ASSOCIATED PROTEIN 5

(Mycobacterium
tuberculosis) 		PF00668
(Condensation)
PF16911
(PapA_C) 		4 ASP A  41
THR A  49
PRO A 157
THR A 156
 None
 1.07A 4yoaA-1q9jA:
0.0		 4yoaA-1q9jA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qyc PHENYLCOUMARAN
BENZYLIC ETHER
REDUCTASE PT1

(Pinus taeda) 		PF05368
(NmrA) 		4 ASN A 154
ASP A 275
PRO A 218
VAL A 188
 None
 1.12A 4yoaA-1qycA:
undetectable		 4yoaA-1qycA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r5j PUTATIVE
PHOSPHOTRANSACETYLAS
E

(Streptococcus
pyogenes) 		PF01515
(PTA_PTB) 		4 ASN A 266
ASP A 197
THR A 189
VAL A 167
 None
 1.14A 4yoaA-1r5jA:
undetectable		 4yoaA-1r5jA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r9j TRANSKETOLASE

(Leishmania
mexicana) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 ASP A 584
THR A 510
PRO A 511
THR A 512
 None
 1.13A 4yoaA-1r9jA:
undetectable		 4yoaA-1r9jA:
8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rdk MANNOSE-BINDING
PROTEIN-C

(Rattus rattus) 		PF00059
(Lectin_C) 		4 ASP 1 166
THR 1 142
PRO 1 143
VAL 1 181
 CA  1 227 ( 2.4A)
None
None
None
 0.87A 4yoaA-1rdk1:
undetectable		 4yoaA-1rdk1:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sig RNA POLYMERASE
PRIMARY SIGMA FACTOR

(Escherichia
coli) 		PF04542
(Sigma70_r2)
PF04546
(Sigma70_ner) 		4 ASN A 362
ASP A 278
THR A 351
VAL A 358
 None
 1.06A 4yoaA-1sigA:
undetectable		 4yoaA-1sigA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uch UBIQUITIN C-TERMINAL
HYDROLASE UCH-L3

(Homo sapiens) 		PF01088
(Peptidase_C12) 		4 ASN A 106
ASP A 109
THR A  81
VAL A 176
 None
 1.13A 4yoaA-1uchA:
undetectable		 4yoaA-1uchA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v2b 23-KDA POLYPEPTIDE
OF PHOTOSYSTEM II
OXYGEN-EVOLVING
COMPLEX

(Nicotiana
tabacum) 		PF01789
(PsbP) 		4 ASP A  85
THR A  64
PRO A  65
THR A  66
 None
 1.12A 4yoaA-1v2bA:
undetectable		 4yoaA-1v2bA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhc PUTATIVE KHG/KDPG
ALDOLASE

(Haemophilus
influenzae) 		PF01081
(Aldolase) 		4 ASN A  39
ASP A 198
PRO A  19
VAL A 204
 None
 1.02A 4yoaA-1vhcA:
undetectable		 4yoaA-1vhcA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x46 HEMOGLOBIN COMPONENT
VII

(Tokunagayusurika
akamusi) 		PF00042
(Globin) 		4 ASP A  11
PRO A   2
THR A   3
VAL A   5
 None
 1.10A 4yoaA-1x46A:
undetectable		 4yoaA-1x46A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z9l VESICLE-ASSOCIATED
MEMBRANE
PROTEIN-ASSOCIATED
PROTEIN A

(Rattus
norvegicus) 		PF00635
(Motile_Sperm) 		4 ASN A  34
ASP A  37
THR A  92
VAL A  40
 None
 1.11A 4yoaA-1z9lA:
undetectable		 4yoaA-1z9lA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a4c CADHERIN-11

(Mus musculus) 		PF00028
(Cadherin) 		4 ASP A  52
PRO A  18
THR A  60
VAL A  49
 None
 0.85A 4yoaA-2a4cA:
undetectable		 4yoaA-2a4cA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2an1 PUTATIVE KINASE

(Salmonella
enterica) 		PF01513
(NAD_kinase) 		4 ASP A 264
THR A 183
PRO A 184
THR A 185
 ASP  A 264 ( 0.6A)
THR  A 183 ( 0.8A)
PRO  A 184 ( 1.1A)
THR  A 185 ( 0.8A)
 1.14A 4yoaA-2an1A:
undetectable		 4yoaA-2an1A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfu PROBABLE
2-HYDROXYHEPTA-2,4-D
IENE-1,7-DIOATE
ISOMERASE

(Thermus
thermophilus) 		PF01557
(FAA_hydrolase)
PF10370
(DUF2437) 		4 ASP A  35
THR A  30
PRO A  29
THR A  22
 None
 1.05A 4yoaA-2dfuA:
undetectable		 4yoaA-2dfuA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ha9 UPF0210 PROTEIN
SP0239

(Streptococcus
pneumoniae) 		PF05167
(DUF711) 		4 ASN A 422
THR A 370
PRO A 371
THR A 374
 None
 1.03A 4yoaA-2ha9A:
undetectable		 4yoaA-2ha9A:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)

(Homo sapiens) 		PF03199
(GSH_synthase)
PF03917
(GSH_synth_ATP) 		4 ASP A  71
THR A 147
THR A 299
VAL A  76
 None
 1.15A 4yoaA-2hgsA:
undetectable		 4yoaA-2hgsA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mgv BIFUNCTIONAL
MEMBRANE-ASSOCIATED
PENICILLIN-BINDING
PROTEIN 1A/1B PONA2

(Mycobacterium
tuberculosis) 		PF03793
(PASTA) 		4 ASP A  13
THR A  45
PRO A  47
VAL A   7
 None
 0.91A 4yoaA-2mgvA:
undetectable		 4yoaA-2mgvA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyx TRYPTOPHAN
HALOGENASE

(Shewanella
frigidimarina) 		PF04820
(Trp_halogenase) 		4 ASN A 393
ASP A 386
THR A 373
VAL A 392
 None
 1.07A 4yoaA-2pyxA:
undetectable		 4yoaA-2pyxA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3z TRANSGLUTAMINASE 2

(Homo sapiens) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		4 ASN A 300
ASP A 358
THR A 442
THR A 440
 None
 1.11A 4yoaA-2q3zA:
undetectable		 4yoaA-2q3zA:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qgs PROTEIN SE1688

(Staphylococcus
epidermidis) 		no annotation 4 ASN A  45
THR A 187
PRO A 188
THR A 189
 None
 1.13A 4yoaA-2qgsA:
undetectable		 4yoaA-2qgsA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qym PHOSPHODIESTERASE 4C

(Homo sapiens) 		PF00233
(PDEase_I) 		4 ASP A 220
PRO A 301
THR A 300
VAL A 296
 None
 0.85A 4yoaA-2qymA:
undetectable		 4yoaA-2qymA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Staphylococcus
haemolyticus) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		4 ASP B 152
PRO B 144
THR B 145
VAL B 147
 None
 0.82A 4yoaA-2rhqB:
undetectable		 4yoaA-2rhqB:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rmp MUCOROPEPSIN

(Rhizomucor
miehei) 		PF00026
(Asp) 		4 ASN A 152
ASP A 139
PRO A 167
VAL A 156
 None
 1.14A 4yoaA-2rmpA:
5.6		 4yoaA-2rmpA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vf8 EXCINUCLEASE ABC
SUBUNIT A

(Deinococcus
radiodurans) 		PF00005
(ABC_tran) 		4 ASP A 688
THR A 619
PRO A 620
VAL A 679
 None
 1.14A 4yoaA-2vf8A:
undetectable		 4yoaA-2vf8A:
7.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vmf BETA-MANNOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2) 		4 ASN A 265
THR A 304
PRO A 305
THR A 306
 None
EDO  A1896 (-3.6A)
None
EDO  A1896 (-3.5A)
 1.09A 4yoaA-2vmfA:
undetectable		 4yoaA-2vmfA:
7.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnx GLYCOSIDE HYDROLASE,
FAMILY 9

(Ruminiclostridium
thermocellum) 		PF00942
(CBM_3) 		4 ASP A 138
THR A  32
PRO A 115
THR A 113
 None
 1.08A 4yoaA-2wnxA:
undetectable		 4yoaA-2wnxA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2

(Saccharomyces
cerevisiae) 		PF04072
(LCM)
PF13418
(Kelch_4) 		4 ASN A 247
THR A 103
PRO A 104
VAL A 218
 None
 0.95A 4yoaA-2zwaA:
undetectable		 4yoaA-2zwaA:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a24 ALPHA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		4 ASP A 281
PRO A 194
THR A 208
VAL A 274
 None
 1.15A 4yoaA-3a24A:
undetectable		 4yoaA-3a24A:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hs3 RIBOSE OPERON
REPRESSOR

(Lactobacillus
acidophilus) 		PF13377
(Peripla_BP_3) 		4 ASN A 235
THR A 209
PRO A 210
VAL A 234
 None
 1.13A 4yoaA-3hs3A:
undetectable		 4yoaA-3hs3A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3o SHORT CHAIN
DEHYDROGENASE

(Bacillus
anthracis) 		PF13561
(adh_short_C2) 		4 ASN A 187
ASP A 192
PRO A 223
VAL A 182
 None
None
NAE  A 311 (-4.0A)
NAE  A 311 (-4.6A)
 1.04A 4yoaA-3i3oA:
undetectable		 4yoaA-3i3oA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 2
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 3

(Thermus
thermophilus) 		PF00384
(Molybdopterin)
PF01257
(2Fe-2S_thioredx)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4)
PF10588
(NADH-G_4Fe-4S_3)
PF13510
(Fer2_4) 		4 THR 2  56
PRO 2  57
THR 2  58
VAL 3 199
 None
 0.74A 4yoaA-3i9v2:
undetectable		 4yoaA-3i9v2:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipi GERANYLTRANSTRANSFER
ASE

(Methanosarcina
mazei) 		PF00348
(polyprenyl_synt) 		4 ASP A 255
THR A 288
THR A 284
VAL A 261
 None
 1.15A 4yoaA-3ipiA:
undetectable		 4yoaA-3ipiA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jd5 28S RIBOSOMAL
PROTEIN S17,
MITOCHONDRIAL
28S RIBOSOMAL
PROTEIN S25,
MITOCHONDRIAL
28S RIBOSOMAL
PROTEIN S26,
MITOCHONDRIAL

(Bos taurus) 		PF00366
(Ribosomal_S17)
PF14955
(MRP-S24)
no annotation 		4 ASN d 113
THR c  73
PRO c  74
VAL Q  95
 None
 1.07A 4yoaA-3jd5d:
undetectable		 4yoaA-3jd5d:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkd TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Streptococcus
thermophilus) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		4 ASP A 336
THR A 201
PRO A 202
VAL A 357
 None
 1.02A 4yoaA-3lkdA:
undetectable		 4yoaA-3lkdA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwr A RUBISCO-LIKE
PROTEIN

(Paraburkholderia
fungorum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 ASP A 238
THR A 277
PRO A 278
VAL A 258
 GOL  A 439 (-3.0A)
None
None
None
 1.08A 4yoaA-3nwrA:
undetectable		 4yoaA-3nwrA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvl MYOSIN VIIA ISOFORM
1

(Mus musculus) 		PF00784
(MyTH4) 		4 ASN A1160
ASP A1034
THR A1044
VAL A1041
 None
GOL  A   5 (-4.0A)
None
None
 1.08A 4yoaA-3pvlA:
undetectable		 4yoaA-3pvlA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q33 HISTONE
ACETYLTRANSFERASE
RTT109

(Saccharomyces
cerevisiae) 		PF08214
(HAT_KAT11) 		4 ASP A 301
THR A  34
PRO A  35
VAL A 279
 None
 1.11A 4yoaA-3q33A:
undetectable		 4yoaA-3q33A:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qr1 PHOSPHOLIPASE C-BETA
(PLC-BETA)

(Doryteuthis
pealeii) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		4 ASP A 645
PRO A 679
THR A 680
VAL A 712
 None
 1.07A 4yoaA-3qr1A:
undetectable		 4yoaA-3qr1A:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rrl SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE SUBUNIT
A
SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE SUBUNIT
B

(Helicobacter
pylori) 		PF01144
(CoA_trans) 		4 ASP B  83
THR A 119
PRO A 120
THR A 121
 None
 1.15A 4yoaA-3rrlB:
undetectable		 4yoaA-3rrlB:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3srt MALTOSE
O-ACETYLTRANSFERASE

(Clostridioides
difficile) 		PF12464
(Mac)
PF14602
(Hexapep_2) 		4 ASN A 175
THR A 145
THR A 163
VAL A 161
 None
 0.99A 4yoaA-3srtA:
undetectable		 4yoaA-3srtA:
19.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3t3c HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 ASP A  29
THR A  80
PRO A  81
VAL A  84
 017  A 201 (-3.5A)
None
None
None
 0.53A 4yoaA-3t3cA:
17.4		 4yoaA-3t3cA:
74.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3u7s POL POLYPROTEIN

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 ASP A  29
THR A  80
PRO A  81
VAL A  84
 017  A 201 (-3.2A)
None
017  A 202 (-4.0A)
None
 0.28A 4yoaA-3u7sA:
18.6		 4yoaA-3u7sA:
81.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufk UNDA

(Shewanella sp.
HRCR_06) 		PF13435
(Cytochrome_C554) 		4 ASP A  59
PRO A  80
THR A  74
VAL A  72
 None
 1.00A 4yoaA-3ufkA:
undetectable		 4yoaA-3ufkA:
8.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uhl PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 ASP A  29
THR A  80
PRO A  81
VAL A  84
 None
 0.59A 4yoaA-3uhlA:
17.5		 4yoaA-3uhlA:
82.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uma HYPOTHETICAL
PEROXIREDOXIN
PROTEIN

(Sinorhizobium
meliloti) 		PF08534
(Redoxin) 		4 ASP A 115
THR A  46
PRO A  47
THR A  48
 None
 0.80A 4yoaA-3umaA:
undetectable		 4yoaA-3umaA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3up3 ACEDAF-12

(Ancylostoma
ceylanicum) 		PF00104
(Hormone_recep) 		4 ASP A 493
THR A 546
PRO A 547
THR A 548
 None
XCA  A 100 (-3.7A)
XCA  A 100 (-4.8A)
EDO  A 200 (-3.4A)
 0.75A 4yoaA-3up3A:
undetectable		 4yoaA-3up3A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 ASN A4650
THR A4662
PRO A4663
VAL A4648
 None
 1.09A 4yoaA-3vkgA:
undetectable		 4yoaA-3vkgA:
2.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vys HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPD

(Thermococcus
kodakarensis) 		PF01924
(HypD) 		4 ASN B 170
ASP B 139
THR B 130
VAL B 142
 None
 1.04A 4yoaA-3vysB:
undetectable		 4yoaA-3vysB:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w8s GLUTATHIONE
S-TRANSFERASE-3

(Necator
americanus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 ASN A 122
ASP A 116
THR A 171
PRO A 172
 None
 0.87A 4yoaA-3w8sA:
undetectable		 4yoaA-3w8sA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wx7 CHITIN
OLIGOSACCHARIDE
DEACETYLASE

(Vibrio
parahaemolyticus) 		PF01522
(Polysacc_deac_1) 		4 ASP A 174
THR A 332
PRO A 333
VAL A 353
 None
None
GOL  A 904 (-4.6A)
None
 1.10A 4yoaA-3wx7A:
undetectable		 4yoaA-3wx7A:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x43 O-UREIDO-L-SERINE
SYNTHASE

(Streptomyces
lavendulae) 		PF00291
(PALP) 		4 ASP A 170
THR A 272
THR A 269
VAL A 173
 None
 1.00A 4yoaA-3x43A:
undetectable		 4yoaA-3x43A:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zif HEXON PROTEIN

(Bovine
mastadenovirus
B) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		4 ASN A 122
THR A 262
PRO A 263
THR A 265
 None
 1.15A 4yoaA-3zifA:
undetectable		 4yoaA-3zifA:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayz HEME-BINDING PROTEIN
2

(Homo sapiens) 		PF04832
(SOUL) 		4 ASP A  57
THR A 106
THR A  51
VAL A  53
 None
 1.15A 4yoaA-4ayzA:
undetectable		 4yoaA-4ayzA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bf7 ARABINOGALACTAN
ENDO-1,4-BETA-GALACT
OSIDASE A

(Aspergillus
nidulans) 		PF07745
(Glyco_hydro_53) 		4 ASN A 153
ASP A 149
THR A 199
THR A 201
 ZN  A 404 ( 4.3A)
None
None
IMD  A1342 (-4.1A)
 0.94A 4yoaA-4bf7A:
undetectable		 4yoaA-4bf7A:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE

(Escherichia
coli;
Escherichia
virus Qbeta) 		PF00009
(GTP_EFTU)
PF00889
(EF_TS)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2)
PF03431
(RNA_replicase_B) 		4 ASN A 420
ASP A 306
THR A 301
VAL A 389
 None
 1.14A 4yoaA-4fwtA:
undetectable		 4yoaA-4fwtA:
5.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ha4 BETA-GALACTOSIDASE

(Acidilobus
saccharovorans) 		PF00232
(Glyco_hydro_1) 		4 ASN A 368
ASP A 375
PRO A 271
THR A 270
 None
 0.93A 4yoaA-4ha4A:
undetectable		 4yoaA-4ha4A:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hao PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE

(Yersinia pestis) 		PF01513
(NAD_kinase) 		4 ASP A 264
THR A 183
PRO A 184
THR A 185
 None
 1.08A 4yoaA-4haoA:
undetectable		 4yoaA-4haoA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2

(Homo sapiens) 		PF00069
(Pkinase) 		4 ASP A 262
PRO A 278
THR A 272
VAL A 269
 None
 1.01A 4yoaA-4i6fA:
undetectable		 4yoaA-4i6fA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0q ELONGATION FACTOR
TU-A

(Pseudomonas
putida) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		4 ASN A 136
ASP A  22
THR A  17
VAL A 105
 GDP  A 402 (-3.4A)
GDP  A 402 (-3.7A)
None
None
 1.07A 4yoaA-4j0qA:
undetectable		 4yoaA-4j0qA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0q ELONGATION FACTOR
TU-A

(Pseudomonas
putida) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		4 ASN A 136
ASP A 110
THR A  17
VAL A 105
 GDP  A 402 (-3.4A)
None
None
None
 1.12A 4yoaA-4j0qA:
undetectable		 4yoaA-4j0qA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kgb SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE

(Drosophila
melanogaster) 		PF01144
(CoA_trans) 		4 ASP A 380
THR A 151
PRO A 152
THR A 153
 None
 1.09A 4yoaA-4kgbA:
undetectable		 4yoaA-4kgbA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lbw ELONGATION FACTOR
TU-A

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		4 ASN A 136
ASP A  21
THR A  16
VAL A 105
 GNP  A 501 (-3.2A)
GNP  A 501 (-3.4A)
None
None
 1.14A 4yoaA-4lbwA:
undetectable		 4yoaA-4lbwA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ml9 UNCHARACTERIZED
PROTEIN

(Sebaldella
termitidis) 		PF00977
(His_biosynth) 		4 ASP A 249
THR A 233
PRO A 232
VAL A 226
 None
None
EDO  A 309 (-3.2A)
None
 1.14A 4yoaA-4ml9A:
undetectable		 4yoaA-4ml9A:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4my5 PUTATIVE AMINO ACID
AMINOTRANSFERASE

(Streptococcus
mutans) 		PF00155
(Aminotran_1_2) 		4 ASP A 318
PRO A 153
THR A 152
VAL A 150
 None
 0.92A 4yoaA-4my5A:
undetectable		 4yoaA-4my5A:
18.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4njv PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 ASP A  29
THR A  80
PRO A  81
THR A  82
 RIT  A 500 (-3.2A)
None
RIT  A 500 (-3.9A)
RIT  A 500 (-3.5A)
 0.41A 4yoaA-4njvA:
18.5		 4yoaA-4njvA:
86.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzr PROTEIN M TD

(Mycoplasma
genitalium) 		no annotation 4 ASN M 183
ASP M 339
THR M 137
PRO M 138
 None
 1.05A 4yoaA-4nzrM:
undetectable		 4yoaA-4nzrM:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5p UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF09994
(DUF2235) 		4 ASP A 688
THR A 608
THR A 700
VAL A 781
 None
 1.10A 4yoaA-4o5pA:
undetectable		 4yoaA-4o5pA:
7.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pf6 C4-DICARBOXYLATE-BIN
DING PROTEIN

(Roseobacter
denitrificans) 		PF03480
(DctP) 		4 ASP A 209
PRO A 296
THR A 233
VAL A 150
 None
 1.13A 4yoaA-4pf6A:
undetectable		 4yoaA-4pf6A:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pw5 E3 UBIQUITIN-PROTEIN
LIGASE UHRF2

(Homo sapiens) 		PF02182
(SAD_SRA) 		4 ASN A 582
ASP A 585
PRO A 473
VAL A 465
 None
 1.11A 4yoaA-4pw5A:
undetectable		 4yoaA-4pw5A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u6d CONSERVED
HYPOTHETICAL
PERIPLASMIC PROTEIN

(Zobellia
galactanivorans) 		no annotation 4 ASN A 120
THR A 109
PRO A 110
THR A 111
 None
 0.83A 4yoaA-4u6dA:
undetectable		 4yoaA-4u6dA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wiw GLYCOSIDE HYDROLASE
FAMILY 18

(Desulfitobacterium
hafniense) 		PF00704
(Glyco_hydro_18) 		4 ASP A 533
THR A 625
PRO A 626
THR A 627
 None
 1.12A 4yoaA-4wiwA:
undetectable		 4yoaA-4wiwA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zv4 ELONGATION FACTOR TU

(Pseudomonas
aeruginosa) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		4 ASN A 136
ASP A 110
THR A  17
VAL A 105
 GDP  A 501 (-3.6A)
None
None
None
 0.98A 4yoaA-4zv4A:
1.9		 4yoaA-4zv4A:
15.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5b18 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 ASN A  25
ASP A  29
THR A  80
PRO A  81
 None
 0.74A 4yoaA-5b18A:
17.6		 4yoaA-5b18A:
80.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT

(Sulfurisphaera
tokodaii) 		PF01558
(POR)
PF01855
(POR_N)
PF17147
(PFOR_II) 		4 ASP A 387
PRO A 336
THR A 400
VAL A 402
 None
 1.07A 4yoaA-5b47A:
undetectable		 4yoaA-5b47A:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b48 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT

(Sulfurisphaera
tokodaii) 		PF01558
(POR)
PF01855
(POR_N) 		4 ASP A 387
PRO A 336
THR A 400
VAL A 402
 None
 1.06A 4yoaA-5b48A:
undetectable		 4yoaA-5b48A:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7u CYCLOALTERNAN-FORMIN
G ENZYME

(Listeria
monocytogenes) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF16990
(CBM_35) 		4 ASN A 261
THR A 144
THR A 257
VAL A 262
 None
 1.03A 4yoaA-5f7uA:
undetectable		 4yoaA-5f7uA:
6.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu4 CYSTEINE PROTEASE

(Listeria
monocytogenes) 		PF04203
(Sortase) 		4 ASP A  97
PRO A  52
THR A 113
VAL A 128
 None
 1.15A 4yoaA-5hu4A:
undetectable		 4yoaA-5hu4A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i1w CRMK

(Actinoalloteichus
sp. WH1-2216-6) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 ASN A 460
PRO A 438
THR A 437
VAL A 435
 None
 0.92A 4yoaA-5i1wA:
undetectable		 4yoaA-5i1wA:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ket ALDO-KETO REDUCTASE
1

(Coptotermes
gestroi) 		PF00248
(Aldo_ket_red) 		4 ASN A  54
ASP A  47
THR A  61
VAL A  31
 None
NAP  A 400 (-2.8A)
None
None
 0.99A 4yoaA-5ketA:
undetectable		 4yoaA-5ketA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5x DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA135

(Saccharomyces
cerevisiae) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF06883
(RNA_pol_Rpa2_4) 		4 ASN B 755
THR B 692
PRO B 693
THR B 694
 None
 0.95A 4yoaA-5m5xB:
undetectable		 4yoaA-5m5xB:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mza ERYTHROCYTE MEMBRANE
PROTEIN 1 (PFEMP1)

(Plasmodium
falciparum) 		PF05424
(Duffy_binding) 		4 ASN A 811
THR A 819
PRO A 820
VAL A 813
 None
 0.99A 4yoaA-5mzaA:
undetectable		 4yoaA-5mzaA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nue MALATE DEHYDROGENASE
1, CYTOPLASMIC

(Arabidopsis
thaliana) 		no annotation 4 THR A 262
PRO A 263
THR A 266
VAL A 268
 None
 1.07A 4yoaA-5nueA:
undetectable		 4yoaA-5nueA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o6u UNCHARACTERIZED
PROTEIN

(Shewanella
putrefaciens) 		no annotation 4 ASN C 230
ASP C 188
THR C 236
VAL C 232
 None
 1.02A 4yoaA-5o6uC:
undetectable		 4yoaA-5o6uC:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u25 DIHYDROLIPOAMIDE
DEHYDROGENASE (E3
COMPONENT OF
PYRUVATE AND
2-OXOGLUTARATE
DEHYDROGENASE
COMPLEXES)

(Neisseria
gonorrhoeae) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 ASP A 115
THR A 252
PRO A 251
THR A 241
 None
 1.09A 4yoaA-5u25A:
undetectable		 4yoaA-5u25A:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1e PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		no annotation 4 ASP A 401
THR A 409
PRO A 376
VAL A 398
 None
 1.07A 4yoaA-5w1eA:
undetectable		 4yoaA-5w1eA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wrp PYRUVATE KINASE

(Mycobacterium
tuberculosis) 		no annotation 4 ASP A 236
THR A 374
THR A 396
VAL A 401
 None
PO4  A 501 (-3.4A)
None
None
 1.13A 4yoaA-5wrpA:
undetectable		 4yoaA-5wrpA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x1t PPKA-294

(Serratia sp.
FS14) 		no annotation 4 ASP A 225
PRO A 241
THR A 235
VAL A 232
 None
 1.10A 4yoaA-5x1tA:
undetectable		 4yoaA-5x1tA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgz BETA-GLYCOSIDASE

(uncultured
microorganism) 		no annotation 4 ASN A 261
ASP A 346
PRO A 290
THR A 288
 None
 1.12A 4yoaA-5xgzA:
undetectable		 4yoaA-5xgzA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ydj ACETYLCHOLINESTERASE

(Anopheles
gambiae) 		no annotation 4 ASN A 565
ASP A 557
THR A 480
VAL A 564
 None
 0.99A 4yoaA-5ydjA:
undetectable		 4yoaA-5ydjA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yly NITRATE REDUCTASE

(Ulva prolifera) 		no annotation 4 ASP A 618
THR A 746
THR A 664
VAL A 676
 None
FAD  A1001 (-2.8A)
None
None
 0.91A 4yoaA-5ylyA:
undetectable		 4yoaA-5ylyA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6arx ACETYLCHOLINESTERASE

(Anopheles
gambiae) 		no annotation 4 ASN A 565
ASP A 557
THR A 480
VAL A 564
 None
 0.96A 4yoaA-6arxA:
undetectable		 4yoaA-6arxA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fjy PROTEIN CSUE

(Acinetobacter
baumannii) 		no annotation 4 ASN D 213
PRO D 272
THR D 279
VAL D 212
 None
 1.08A 4yoaA-6fjyD:
undetectable		 4yoaA-6fjyD:
15.38