SIMILAR PATTERNS OF AMINO ACIDS FOR 4YO9_B_ACTB401

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cia CHLORAMPHENICOL
ACETYLTRANSFERASE

(Escherichia
coli) 		PF00302
(CAT) 		3 ARG A  18
ASP A 199
TYR A  25
 None
 0.81A 4yo9B-1ciaA:
0.0		 4yo9B-1ciaA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e51 DELTA-AMINOLEVULINIC
ACID DEHYDRATASE

(Homo sapiens) 		PF00490
(ALAD) 		3 ARG A 174
ASP A 169
TYR A 196
 None
 0.89A 4yo9B-1e51A:
0.0		 4yo9B-1e51A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eb3 5-AMINOLAEVULINIC
ACID DEHYDRATASE

(Saccharomyces
cerevisiae) 		PF00490
(ALAD) 		3 ARG A 185
ASP A 180
TYR A 207
 None
None
DSB  A1341 ( 4.5A)
 0.94A 4yo9B-1eb3A:
0.0		 4yo9B-1eb3A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f2d 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE

(Cyberlindnera
saturnus) 		PF00291
(PALP) 		3 ARG A 263
ASP A 261
TYR A 311
 None
 0.76A 4yo9B-1f2dA:
undetectable		 4yo9B-1f2dA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpe PROTEIN (GLUCOSE
OXIDASE)

(Penicillium
amagasakiense) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		3 ARG A 229
ASP A 113
TYR A  73
 None
 0.63A 4yo9B-1gpeA:
0.2		 4yo9B-1gpeA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gqj ALPHA-D-GLUCURONIDAS
E

(Cellvibrio
japonicus) 		PF03648
(Glyco_hydro_67N)
PF07477
(Glyco_hydro_67C)
PF07488
(Glyco_hydro_67M) 		3 ARG A 560
ASP A 335
TYR A 548
 None
 0.72A 4yo9B-1gqjA:
0.0		 4yo9B-1gqjA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzg DELTA-AMINOLEVULINIC
ACID DEHYDRATASE

(Pseudomonas
aeruginosa) 		PF00490
(ALAD) 		3 ARG A 181
ASP A 176
TYR A 202
 MG  A1338 (-4.7A)
None
LAF  A1337 ( 4.6A)
 0.87A 4yo9B-1gzgA:
0.0		 4yo9B-1gzgA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lox 15-LIPOXYGENASE

(Oryctolagus
cuniculus) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		3 ARG A 451
ASP A 447
TYR A 461
 None
 0.95A 4yo9B-1loxA:
0.3		 4yo9B-1loxA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qni NITROUS-OXIDE
REDUCTASE

(Marinobacter
hydrocarbonoclasticus) 		no annotation 3 ARG A 109
ASP A 111
TYR A 453
 None
 0.86A 4yo9B-1qniA:
0.4		 4yo9B-1qniA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qvr CLPB PROTEIN

(Thermus
thermophilus) 		PF00004
(AAA)
PF02861
(Clp_N)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		3 ARG A 139
ASP A 109
TYR A 150
 None
 0.88A 4yo9B-1qvrA:
undetectable		 4yo9B-1qvrA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tl2 PROTEIN
(TACHYLECTIN-2)

(Tachypleus
tridentatus) 		PF14517
(Tachylectin) 		3 ARG A  31
ASP A  26
TYR A  20
 None
 0.80A 4yo9B-1tl2A:
undetectable		 4yo9B-1tl2A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5u ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN

(Plexaura
homomalla) 		no annotation 3 ARG A 243
ASP A 110
TYR A 253
 None
 0.61A 4yo9B-1u5uA:
undetectable		 4yo9B-1u5uA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uar RHODANESE

(Thermus
thermophilus) 		PF00581
(Rhodanese) 		3 ARG A 115
ASP A  30
TYR A  36
 None
 0.90A 4yo9B-1uarA:
undetectable		 4yo9B-1uarA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ut9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N) 		3 ARG A 487
ASP A 353
TYR A 382
 None
 0.91A 4yo9B-1ut9A:
undetectable		 4yo9B-1ut9A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v19 2-KETO-3-DEOXYGLUCON
ATE KINASE

(Thermus
thermophilus) 		PF00294
(PfkB) 		3 ARG A  91
ASP A 245
TYR A  31
 None
 0.81A 4yo9B-1v19A:
undetectable		 4yo9B-1v19A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfd DIPEPTIDYL
AMINOPEPTIDASE-LIKE
PROTEIN 6

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		3 ARG A 705
ASP A 702
TYR A 622
 None
 0.96A 4yo9B-1xfdA:
undetectable		 4yo9B-1xfdA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1h DELTA-AMINOLEVULINIC
ACID DEHYDRATASE

(Prosthecochloris
vibrioformis) 		PF00490
(ALAD) 		3 ARG A 176
ASP A 171
TYR A 197
 MG  A1329 (-4.2A)
None
None
 0.90A 4yo9B-2c1hA:
undetectable		 4yo9B-2c1hA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dh3 4F2 CELL-SURFACE
ANTIGEN HEAVY CHAIN

(Homo sapiens) 		PF00128
(Alpha-amylase) 		3 ARG A 247
ASP A 206
TYR A 211
 None
 0.86A 4yo9B-2dh3A:
undetectable		 4yo9B-2dh3A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2flq NITRIC OXIDE
SYNTHASE

(Geobacillus
stearothermophilus) 		PF02898
(NO_synthase) 		3 ARG A 365
ASP A 225
TYR A 362
 None
None
HEM  A 901 (-4.3A)
 0.81A 4yo9B-2flqA:
undetectable		 4yo9B-2flqA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcu PUTATIVE
HYDROXYACYLGLUTATHIO
NE HYDROLASE 3

(Arabidopsis
thaliana) 		PF00753
(Lactamase_B) 		3 ARG A 162
ASP A 164
TYR A 232
 SO4  A3001 (-3.9A)
None
None
 0.87A 4yo9B-2gcuA:
undetectable		 4yo9B-2gcuA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gie TYPE II RESTRICTION
ENZYME HINCII

(Haemophilus
influenzae) 		PF09226
(Endonuc-HincII) 		3 ARG A  91
ASP A 111
TYR A  57
 None
 0.94A 4yo9B-2gieA:
undetectable		 4yo9B-2gieA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gu2 ASPA PROTEIN

(Rattus
norvegicus) 		PF04952
(AstE_AspA) 		3 ARG A 232
ASP A 229
TYR A 288
 None
 0.87A 4yo9B-2gu2A:
undetectable		 4yo9B-2gu2A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjq UNCHARACTERIZED RNA
METHYLTRANSFERASE
PYRAB10780

(Pyrococcus
abyssi) 		PF05958
(tRNA_U5-meth_tr) 		3 ARG A 110
ASP A 112
TYR A 222
 None
 0.80A 4yo9B-2jjqA:
undetectable		 4yo9B-2jjqA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4b SIGMA-E FACTOR
REGULATORY PROTEIN
RSEB

(Escherichia
coli) 		PF03888
(MucB_RseB)
PF17188
(MucB_RseB_C) 		3 ARG A 153
ASP A 150
TYR A 125
 None
 0.84A 4yo9B-2p4bA:
1.8		 4yo9B-2p4bA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vif SUPPRESSOR OF
CYTOKINE SIGNALLING
6

(Homo sapiens) 		PF00017
(SH2) 		3 ARG A 415
ASP A 413
TYR A 443
 None
 0.90A 4yo9B-2vifA:
undetectable		 4yo9B-2vifA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ztg ALANYL-TRNA
SYNTHETASE

(Archaeoglobus
fulgidus) 		PF01411
(tRNA-synt_2c)
PF07973
(tRNA_SAD) 		3 ARG A 593
ASP A 546
TYR A 508
 None
 0.87A 4yo9B-2ztgA:
undetectable		 4yo9B-2ztgA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zzg ALANYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF01411
(tRNA-synt_2c)
PF07973
(tRNA_SAD) 		3 ARG A 606
ASP A 558
TYR A 520
 None
 0.93A 4yo9B-2zzgA:
undetectable		 4yo9B-2zzgA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1j CELL CYCLE
CHECKPOINT PROTEIN
RAD1

(Homo sapiens) 		PF02144
(Rad1) 		3 ARG C 248
ASP C 246
TYR C 270
 None
 0.89A 4yo9B-3a1jC:
undetectable		 4yo9B-3a1jC:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9v 4-COUMARATE--COA
LIGASE

(Populus
tomentosa) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 ARG A 300
ASP A 224
TYR A 219
 None
 0.69A 4yo9B-3a9vA:
undetectable		 4yo9B-3a9vA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aib GLUCOSYLTRANSFERASE-
SI

(Streptococcus
mutans) 		PF02324
(Glyco_hydro_70) 		3 ARG A 420
ASP A 418
TYR A 524
 None
 0.89A 4yo9B-3aibA:
undetectable		 4yo9B-3aibA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bg9 PYRUVATE
CARBOXYLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		3 ARG A 617
ASP A 613
TYR A 651
 None
 0.62A 4yo9B-3bg9A:
undetectable		 4yo9B-3bg9A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3btp SINGLE-STRAND
DNA-BINDING PROTEIN

(Agrobacterium
fabrum) 		PF07229
(VirE2) 		3 ARG A 244
ASP A 262
TYR A 241
 None
 0.96A 4yo9B-3btpA:
undetectable		 4yo9B-3btpA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3l ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE

(Homo sapiens) 		PF00305
(Lipoxygenase) 		3 ARG A 450
ASP A 446
TYR A 460
 None
 0.90A 4yo9B-3d3lA:
undetectable		 4yo9B-3d3lA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8d AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER 1

(Homo sapiens) 		PF00640
(PID) 		3 ARG A 483
ASP A 464
TYR A 403
 None
 0.91A 4yo9B-3d8dA:
undetectable		 4yo9B-3d8dA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN

(Plexaura
homomalla) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		3 ARG A 243
ASP A 110
TYR A 253
 None
 0.86A 4yo9B-3dy5A:
undetectable		 4yo9B-3dy5A:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
DNA-DIRECTED RNA
POLYMERASES I, II,
AND III SUBUNIT
RPABC1

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
PF01191
(RNA_pol_Rpb5_C)
PF03871
(RNA_pol_Rpb5_N) 		3 ARG A 863
ASP A 859
TYR E 163
 None
 0.94A 4yo9B-3h0gA:
undetectable		 4yo9B-3h0gA:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7l ENDOGLUCANASE

(Vibrio
parahaemolyticus) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N) 		3 ARG A 227
ASP A 120
TYR A 139
 None
 0.94A 4yo9B-3h7lA:
undetectable		 4yo9B-3h7lA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzu THIOSULFATE
SULFURTRANSFERASE
SSEA

(Mycobacterium
tuberculosis) 		PF00581
(Rhodanese) 		3 ARG A 126
ASP A  41
TYR A  47
 None
 0.94A 4yo9B-3hzuA:
undetectable		 4yo9B-3hzuA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i7f ASPARTYL-TRNA
SYNTHETASE

(Entamoeba
histolytica) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		3 ARG A  64
ASP A 116
TYR A  40
 None
 0.76A 4yo9B-3i7fA:
undetectable		 4yo9B-3i7fA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ik2 ENDOGLUCANASE A

(Clostridium
acetobutylicum) 		PF12891
(Glyco_hydro_44) 		3 ARG A  35
ASP A  26
TYR A  70
 GOL  A 515 (-4.6A)
GOL  A 515 (-4.0A)
GOL  A 515 (-4.2A)
 0.67A 4yo9B-3ik2A:
undetectable		 4yo9B-3ik2A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jby V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1

(Danio rerio) 		PF12940
(RAG1) 		3 ARG A 770
ASP A 753
TYR A 747
 None
 0.90A 4yo9B-3jbyA:
undetectable		 4yo9B-3jbyA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kew DHHA1 DOMAIN PROTEIN

(Clostridium
perfringens) 		PF01411
(tRNA-synt_2c)
PF07973
(tRNA_SAD) 		3 ARG A  89
ASP A  47
TYR A   5
 None
 0.90A 4yo9B-3kewA:
2.5		 4yo9B-3kewA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kmv ALPHA-L-ARABINOFURAN
OSIDASE B

(Ruminiclostridium
thermocellum) 		PF05270
(AbfB) 		3 ARG A 126
ASP A 128
TYR A  75
 None
None
GOL  A 158 (-4.1A)
 0.96A 4yo9B-3kmvA:
undetectable		 4yo9B-3kmvA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l22 SUSD SUPERFAMILY
PROTEIN

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 ARG A 321
ASP A 319
TYR A 314
 None
 0.95A 4yo9B-3l22A:
undetectable		 4yo9B-3l22A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la4 UREASE

(Canavalia
ensiformis) 		PF00449
(Urease_alpha)
PF00547
(Urease_gamma)
PF00699
(Urease_beta)
PF01979
(Amidohydro_1) 		3 ARG A 163
ASP A 162
TYR A 179
 None
 0.92A 4yo9B-3la4A:
undetectable		 4yo9B-3la4A:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mn3 CARBON
CATABOLITE-DEREPRESS
ING PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		3 ARG A 176
ASP A 195
TYR A 106
 None
 0.85A 4yo9B-3mn3A:
undetectable		 4yo9B-3mn3A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nfz ASPARTOACYLASE-2

(Mus musculus) 		PF04952
(AstE_AspA) 		3 ARG A 232
ASP A 229
TYR A 288
 None
 0.89A 4yo9B-3nfzA:
undetectable		 4yo9B-3nfzA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyy PUTATIVE
GLYCYL-GLYCINE
ENDOPEPTIDASE LYTM

([Ruminococcus]
gnavus) 		PF01551
(Peptidase_M23) 		3 ARG A 112
ASP A  63
TYR A  95
 SO4  A 284 (-2.6A)
None
SO4  A 284 (-4.6A)
 0.85A 4yo9B-3nyyA:
undetectable		 4yo9B-3nyyA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3obk DELTA-AMINOLEVULINIC
ACID DEHYDRATASE

(Toxoplasma
gondii) 		PF00490
(ALAD) 		3 ARG A 189
ASP A 184
TYR A 210
 MG  A 365 ( 4.7A)
None
None
 0.93A 4yo9B-3obkA:
undetectable		 4yo9B-3obkA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oja LEUCINE-RICH IMMUNE
MOLECULE 1
ANOPHELES
PLASMODIUM-RESPONSIV
E LEUCINE-RICH
REPEAT PROTEIN 1

(Anopheles
gambiae;
Anopheles
gambiae) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		3 ARG B 656
ASP B 660
TYR A 462
 None
 0.80A 4yo9B-3ojaB:
undetectable		 4yo9B-3ojaB:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3on5 BH1974 PROTEIN

(Bacillus
halodurans) 		PF02625
(XdhC_CoxI)
PF13478
(XdhC_C) 		3 ARG A 242
ASP A 245
TYR A 205
 None
 0.90A 4yo9B-3on5A:
undetectable		 4yo9B-3on5A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s9v ABIETADIENE
SYNTHASE,
CHLOROPLASTIC

(Abies grandis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		3 ARG A 396
ASP A 352
TYR A 349
 None
 0.87A 4yo9B-3s9vA:
undetectable		 4yo9B-3s9vA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t63 PROTOCATECHUATE
3,4-DIOXYGENASE BETA
CHAIN

(Pseudomonas
putida) 		PF00775
(Dioxygenase_C)
PF12391
(PCDO_beta_N) 		3 ARG M 522
ASP M 524
TYR M 436
 None
GOL  M 541 (-4.5A)
None
 0.93A 4yo9B-3t63M:
undetectable		 4yo9B-3t63M:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9s METHYLCROTONYL-COA
CARBOXYLASE,
ALPHA-SUBUNIT

(Pseudomonas
aeruginosa) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		3 ARG A 328
ASP A 326
TYR A 249
 None
 0.88A 4yo9B-3u9sA:
undetectable		 4yo9B-3u9sA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		3 ARG A3914
ASP A3918
TYR A3921
 None
 0.91A 4yo9B-3vkgA:
undetectable		 4yo9B-3vkgA:
7.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wnp CYCLOISOMALTOOLIGOSA
CCHARIDE
GLUCANOTRANSFERASE

(Bacillus
circulans) 		PF13199
(Glyco_hydro_66)
PF16990
(CBM_35) 		3 ARG A 209
ASP A 205
TYR A 182
 None
None
GLC  A 820 (-4.3A)
 0.82A 4yo9B-3wnpA:
0.6		 4yo9B-3wnpA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zx1 OXIDOREDUCTASE,
PUTATIVE

(Campylobacter
jejuni) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 ARG A 416
ASP A 418
TYR A 412
 None
 0.76A 4yo9B-3zx1A:
undetectable		 4yo9B-3zx1A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aby DNA REPAIR PROTEIN
RECN

(Deinococcus
radiodurans) 		PF02463
(SMC_N) 		3 ARG A 384
ASP A 165
TYR A 422
 None
 0.85A 4yo9B-4abyA:
undetectable		 4yo9B-4abyA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ad8 DNA REPAIR PROTEIN
RECN

(Deinococcus
radiodurans) 		PF02463
(SMC_N) 		3 ARG A 383
ASP A 165
TYR A 175
 None
 0.82A 4yo9B-4ad8A:
undetectable		 4yo9B-4ad8A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4blf SINGLE-STRAND
DNA-BINDING PROTEIN

(Agrobacterium
tumefaciens) 		PF07229
(VirE2) 		3 ARG A 244
ASP A 262
TYR A 241
 None
 0.96A 4yo9B-4blfA:
undetectable		 4yo9B-4blfA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cyf PANTETHEINASE

(Homo sapiens) 		PF00795
(CN_hydrolase) 		3 ARG A  89
ASP A 155
TYR A 158
 None
 0.94A 4yo9B-4cyfA:
undetectable		 4yo9B-4cyfA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e3e MAOC DOMAIN PROTEIN
DEHYDRATASE

(Chloroflexus
aurantiacus) 		PF01575
(MaoC_dehydratas) 		3 ARG A 305
ASP A 307
TYR A 179
 None
 0.52A 4yo9B-4e3eA:
undetectable		 4yo9B-4e3eA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f92 U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		3 ARG B1538
ASP B1665
TYR B1676
 None
 0.73A 4yo9B-4f92B:
undetectable		 4yo9B-4f92B:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fd2 CHAPERONE PROTEIN
CLPB

(Thermus
thermophilus) 		PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		3 ARG A 695
ASP A 691
TYR A 646
 None
 0.94A 4yo9B-4fd2A:
undetectable		 4yo9B-4fd2A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fer EXPANSIN-YOAJ

(Bacillus
subtilis) 		PF03330
(DPBB_1) 		3 ARG A  78
ASP A  41
TYR A  44
 SO4  A 303 (-3.0A)
None
SO4  A 303 (-4.6A)
 0.95A 4yo9B-4ferA:
1.6		 4yo9B-4ferA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i4q BEL-BETA TREFOIL

(Boletus edulis) 		no annotation 3 ARG A 121
ASP A 138
TYR A 131
 GOL  A 203 (-3.6A)
GOL  A 203 (-3.0A)
GOL  A 203 ( 3.6A)
 0.87A 4yo9B-4i4qA:
undetectable		 4yo9B-4i4qA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i4s BEL BETA-TREFOIL

(Boletus edulis) 		no annotation 3 ARG A  27
ASP A  44
TYR A  37
 GOL  A 203 (-3.9A)
GOL  A 203 (-3.0A)
GOL  A 203 (-3.6A)
 0.90A 4yo9B-4i4sA:
undetectable		 4yo9B-4i4sA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i4s BEL BETA-TREFOIL

(Boletus edulis) 		no annotation 3 ARG A 121
ASP A 138
TYR A 131
 GOL  A 202 (-3.8A)
GOL  A 202 (-3.0A)
GOL  A 202 (-3.6A)
 0.87A 4yo9B-4i4sA:
undetectable		 4yo9B-4i4sA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ko2 PERIPLASMIC [NIFESE]
HYDROGENASE SMALL
SUBUNIT

(Desulfomicrobium
baculatum) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		3 ARG S 198
ASP S 194
TYR S 243
 None
 0.90A 4yo9B-4ko2S:
undetectable		 4yo9B-4ko2S:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kxz TRANSFORMING GROWTH
FACTOR BETA-2

(Homo sapiens) 		PF00019
(TGF_beta) 		3 ARG A  26
ASP A  27
TYR A  21
 None
 0.71A 4yo9B-4kxzA:
undetectable		 4yo9B-4kxzA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mg4 PHOSPHONOMUTASE

(Burkholderia
cenocepacia) 		PF13714
(PEP_mutase) 		3 ARG A 137
ASP A 185
TYR A 147
 None
 0.90A 4yo9B-4mg4A:
undetectable		 4yo9B-4mg4A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p9u FATTY ACID
METABOLISM REGULATOR
PROTEIN

(Vibrio cholerae) 		no annotation 3 ARG E 105
ASP E 185
TYR E 219
 None
 0.79A 4yo9B-4p9uE:
undetectable		 4yo9B-4p9uE:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT H

(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
PF01191
(RNA_pol_Rpb5_C) 		3 ARG A 861
ASP A 857
TYR H  33
 None
 0.96A 4yo9B-4qiwA:
undetectable		 4yo9B-4qiwA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tnu ASPARTOACYLASE

(Homo sapiens) 		PF04952
(AstE_AspA) 		3 ARG A 233
ASP A 230
TYR A 289
 None
 0.86A 4yo9B-4tnuA:
undetectable		 4yo9B-4tnuA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txg CHITINASE

(Chromobacterium
violaceum) 		PF00704
(Glyco_hydro_18)
PF06483
(ChiC) 		3 ARG A 736
ASP A 698
TYR A 769
 None
 0.94A 4yo9B-4txgA:
undetectable		 4yo9B-4txgA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txw HYALURONOGLUCOSAMINI
DASE

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C) 		3 ARG A 129
ASP A  40
TYR A  -1
 None
 0.92A 4yo9B-4txwA:
undetectable		 4yo9B-4txwA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4utt PUTATIVE
N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE

(Clostridium
perfringens) 		PF04131
(NanE) 		3 ARG A 101
ASP A  97
TYR A  75
 None
None
ACT  A1223 (-4.6A)
 0.87A 4yo9B-4uttA:
undetectable		 4yo9B-4uttA:
20.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wmd ORF1A

(Middle East
respiratory
syndrome-related
coronavirus) 		PF05409
(Peptidase_C30) 		3 ARG A 134
ASP A 200
TYR A 202
 PEG  A 401 ( 4.6A)
PEG  A 401 (-4.3A)
PEG  A 401 ( 4.2A)
 0.39A 4yo9B-4wmdA:
43.6		 4yo9B-4wmdA:
80.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wnx NETRIN-4

(Mus musculus) 		PF00053
(Laminin_EGF)
PF00055
(Laminin_N) 		3 ARG A 227
ASP A 145
TYR A 159
 None
 0.93A 4yo9B-4wnxA:
undetectable		 4yo9B-4wnxA:
19.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yog 3C-LIKE PROTEINASE

(Tylonycteris
bat coronavirus
HKU4) 		PF05409
(Peptidase_C30) 		3 ARG A 134
ASP A 200
TYR A 202
 ACT  A 404 ( 4.4A)
ACT  A 404 ( 4.6A)
ACT  A 404 (-4.0A)
 0.35A 4yo9B-4yogA:
44.6		 4yo9B-4yogA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzr POLYKETIDE
BIOSYNTHESIS
CYTOCHROME P450 PKSS

(Bacillus
subtilis) 		PF00067
(p450) 		3 ARG A  61
ASP A  59
TYR A 302
 ARG  A  61 ( 0.6A)
ASP  A  59 ( 0.6A)
TYR  A 302 ( 1.3A)
 0.83A 4yo9B-4yzrA:
undetectable		 4yo9B-4yzrA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z9a LOW MOLECULAR WEIGHT
PHOSPHOTYROSINE
PROTEIN PHOSPHATASE

(Homo sapiens) 		PF01451
(LMWPc) 		3 ARG A  58
ASP A  56
TYR A 131
 None
None
PMS  A 304 ( 4.6A)
 0.81A 4yo9B-4z9aA:
undetectable		 4yo9B-4z9aA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxz LEVOGLUCOSAN KINASE

(Lipomyces
starkeyi) 		PF03702
(AnmK) 		3 ARG A 161
ASP A 156
TYR A 391
 None
 0.73A 4yo9B-4zxzA:
undetectable		 4yo9B-4zxzA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5axh DEXTRANASE

(Thermoanaerobacter
pseudethanolicus) 		PF13199
(Glyco_hydro_66) 		3 ARG A 211
ASP A 207
TYR A 184
 None
None
GLC  A 703 ( 4.4A)
 0.78A 4yo9B-5axhA:
1.9		 4yo9B-5axhA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dl7 PORIN

(Acinetobacter
baumannii) 		PF03573
(OprD) 		3 ARG A  87
ASP A  33
TYR A  73
 None
 0.86A 4yo9B-5dl7A:
undetectable		 4yo9B-5dl7A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fgl NICR

(Pseudomonas
putida) 		PF00440
(TetR_N) 		3 ARG A  91
ASP A  88
TYR A 154
 6HY  A 301 (-3.3A)
None
6HY  A 301 (-3.4A)
 0.86A 4yo9B-5fglA:
undetectable		 4yo9B-5fglA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fku DNA POLYMERASE III
SUBUNIT ALPHA

(Escherichia
coli) 		PF01336
(tRNA_anti-codon)
PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		3 ARG A 868
ASP A 864
TYR A 858
 None
 0.92A 4yo9B-5fkuA:
undetectable		 4yo9B-5fkuA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h4e BETA 1-3 GLUCANASE

(Clostridium
beijerinckii) 		no annotation 3 ARG A 372
ASP A 396
TYR A 378
 None
 0.62A 4yo9B-5h4eA:
undetectable		 4yo9B-5h4eA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7e RNA 2',3'-CYCLIC
PHOSPHODIESTERASE

(Deinococcus
radiodurans) 		PF02834
(LigT_PEase) 		3 ARG A  71
ASP A  73
TYR A 202
 None
None
GOL  A 301 (-4.7A)
 0.94A 4yo9B-5h7eA:
undetectable		 4yo9B-5h7eA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzr SNF2-FAMILY ATP
DEPENDENT CHROMATIN
REMODELING FACTOR
LIKE PROTEIN

(Thermothelomyces
thermophila) 		PF00176
(SNF2_N)
PF00271
(Helicase_C)
PF14619
(SnAC) 		3 ARG A 912
ASP A 879
TYR A1090
 None
 0.79A 4yo9B-5hzrA:
undetectable		 4yo9B-5hzrA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ir2 CELLULASE

(Parabacteroides
johnsonii) 		PF03737
(RraA-like) 		3 ARG A 117
ASP A 143
TYR A 163
 None
None
NHE  A 301 ( 4.1A)
 0.91A 4yo9B-5ir2A:
undetectable		 4yo9B-5ir2A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum) 		PF00920
(ILVD_EDD) 		3 ARG A 232
ASP A 230
TYR A 325
 None
 0.83A 4yo9B-5j84A:
undetectable		 4yo9B-5j84A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l7v GLYCOSIDE HYDROLASE

(Bacteroides
vulgatus) 		PF13320
(DUF4091) 		3 ARG A 499
ASP A 132
TYR A 488
 None
 0.93A 4yo9B-5l7vA:
undetectable		 4yo9B-5l7vA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN

(Thermothelomyces
thermophila) 		PF07992
(Pyr_redox_2) 		3 ARG A 426
ASP A 133
TYR A 139
 FAD  A 700 ( 4.2A)
FAD  A 700 (-3.2A)
FAD  A 700 (-4.0A)
 0.95A 4yo9B-5mq6A:
undetectable		 4yo9B-5mq6A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o8f GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
BETA-3,GAMMA-AMINOBU
TYRIC ACID RECEPTOR
SUBUNIT
ALPHA-5,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-5

(Homo sapiens) 		no annotation 3 ARG A 277
ASP A 290
TYR A 285
 None
 0.80A 4yo9B-5o8fA:
1.8		 4yo9B-5o8fA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5osb PROTON-GATED ION
CHANNEL,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1

(Mus musculus;
Gloeobacter
violaceus) 		no annotation 3 ARG A 273
ASP A 286
TYR A 281
 None
 0.77A 4yo9B-5osbA:
undetectable		 4yo9B-5osbA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wab PUTATIVE
BETA-GLUCOSIDASE

(Bifidobacterium
adolescentis) 		no annotation 3 ARG A 268
ASP A 266
TYR A 262
 None
 0.91A 4yo9B-5wabA:
undetectable		 4yo9B-5wabA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7h CYCLOISOMALTOOLIGOSA
CCHARIDE
GLUCANOTRANSFERASE

(Paenibacillus
sp. 598K) 		PF13199
(Glyco_hydro_66)
PF16990
(CBM_35) 		3 ARG A 210
ASP A 206
TYR A 183
 None
None
GLC  A 809 ( 4.4A)
 0.86A 4yo9B-5x7hA:
1.1		 4yo9B-5x7hA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bb4 MOUSE MONOCLONAL
ANTIBODY C5.2 FAB
HEAVY CHAIN
MOUSE MONOCLONAL
ANTIBODY C5.2 FAB
LIGHT CHAIN

(Mus musculus;
Mus musculus) 		no annotation
no annotation 		3 ARG H  95
ASP H 101
TYR L  49
 SEP  P 396 ( 3.7A)
None
None
 0.96A 4yo9B-6bb4H:
undetectable		 4yo9B-6bb4H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gdt -

(-) 		no annotation 3 ARG A 227
ASP A 120
TYR A 139
 None
 0.92A 4yo9B-6gdtA:
undetectable		 4yo9B-6gdtA:
undetectable