SIMILAR PATTERNS OF AMINO ACIDS FOR 4YNP_A_SAMA2304_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jqp | DIPEPTIDYL PEPTIDASEI (Rattusnorvegicus) |
PF00112(Peptidase_C1)PF08773(CathepsinC_exc) | 5 | ASP A 104HIS A 103TYR A 75HIS A 23ILE A 28 | None | 1.22A | 4ynpA-1jqpA:undetectable | 4ynpA-1jqpA:19.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1oa4 | ENDO-BETA-1,4-GLUCANASE (Streptomycessp. 11AG8) |
PF01670(Glyco_hydro_12) | 5 | ASP A 62TYR A 17TYR A 103LYS A 177ILE A 105 | None | 1.27A | 4ynpA-1oa4A:undetectable | 4ynpA-1oa4A:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1peg | HISTONE H3METHYLTRANSFERASEDIM-5 (Neurosporacrassa) |
PF00856(SET)PF05033(Pre-SET) | 8 | GLY A 160TRP A 161ASP A 202TYR A 204HIS A 242TYR A 283CYH A 306CYH A 308 | SAH A 319 ( 4.6A)SAH A 319 (-4.8A)SAH A 319 (-3.6A)SAH A 319 (-4.0A)SAH A 319 (-4.3A)SAH A 319 (-4.7A) ZN A 4 ( 2.3A) ZN A 4 (-2.2A) | 0.78A | 4ynpA-1pegA:18.3 | 4ynpA-1pegA:29.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1peg | HISTONE H3METHYLTRANSFERASEDIM-5 (Neurosporacrassa) |
PF00856(SET)PF05033(Pre-SET) | 6 | GLY A 160TRP A 161TYR A 204HIS A 242TYR A 283CYH A 308 | SAH A 319 ( 4.6A)SAH A 319 (-4.8A)SAH A 319 (-4.0A)SAH A 319 (-4.3A)SAH A 319 (-4.7A) ZN A 4 (-2.2A) | 1.26A | 4ynpA-1pegA:18.3 | 4ynpA-1pegA:29.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1peg | HISTONE H3METHYLTRANSFERASEDIM-5 (Neurosporacrassa) |
PF00856(SET)PF05033(Pre-SET) | 5 | GLY A 162TYR A 204HIS A 242TYR A 283CYH A 308 | NoneSAH A 319 (-4.0A)SAH A 319 (-4.3A)SAH A 319 (-4.7A) ZN A 4 (-2.2A) | 1.19A | 4ynpA-1pegA:18.3 | 4ynpA-1pegA:29.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uw0 | DNA LIGASE III (Homo sapiens) |
PF00645(zf-PARP) | 5 | HIS A 52CYH A 18LYS A 19CYH A 21ILE A 25 | ZN A1118 (-3.1A) ZN A1118 (-2.2A)None ZN A1118 (-2.3A)None | 1.40A | 4ynpA-1uw0A:undetectable | 4ynpA-1uw0A:19.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v9x | POLY (ADP-RIBOSE)POLYMERASE (Arabidopsisthaliana) |
PF00645(zf-PARP) | 5 | HIS A 55CYH A 23LYS A 24CYH A 26ILE A 30 | ZN A 200 (-3.1A) ZN A 200 (-2.3A)None ZN A 200 (-2.3A)None | 1.37A | 4ynpA-1v9xA:undetectable | 4ynpA-1v9xA:18.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bk8 | TITIN HEART ISOFORMN2-B (Homo sapiens) |
PF07679(I-set) | 5 | GLY A 38HIS A 9TYR A 20CYH A 74ILE A 7 | None | 1.05A | 4ynpA-2bk8A:undetectable | 4ynpA-2bk8A:19.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r3a | HISTONE-LYSINEN-METHYLTRANSFERASESUV39H2 (Homo sapiens) |
PF00856(SET)PF05033(Pre-SET) | 7 | GLY A 151TRP A 152TYR A 193HIS A 220TYR A 261CYH A 287CYH A 289 | SAM A 304 (-3.5A)NoneSAM A 304 (-4.2A)SAM A 304 (-4.9A)SAM A 304 (-4.9A) ZN A 300 ( 2.3A) ZN A 300 ( 2.3A) | 0.54A | 4ynpA-2r3aA:19.0 | 4ynpA-2r3aA:28.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r3a | HISTONE-LYSINEN-METHYLTRANSFERASESUV39H2 (Homo sapiens) |
PF00856(SET)PF05033(Pre-SET) | 6 | GLY A 151TRP A 152TYR A 193HIS A 220TYR A 261CYH A 289 | SAM A 304 (-3.5A)NoneSAM A 304 (-4.2A)SAM A 304 (-4.9A)SAM A 304 (-4.9A) ZN A 300 ( 2.3A) | 1.49A | 4ynpA-2r3aA:19.0 | 4ynpA-2r3aA:28.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r3a | HISTONE-LYSINEN-METHYLTRANSFERASESUV39H2 (Homo sapiens) |
PF00856(SET)PF05033(Pre-SET) | 6 | GLY A 153TYR A 193HIS A 220TYR A 261CYH A 287CYH A 289 | NoneSAM A 304 (-4.2A)SAM A 304 (-4.9A)SAM A 304 (-4.9A) ZN A 300 ( 2.3A) ZN A 300 ( 2.3A) | 1.42A | 4ynpA-2r3aA:19.0 | 4ynpA-2r3aA:28.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r3a | HISTONE-LYSINEN-METHYLTRANSFERASESUV39H2 (Homo sapiens) |
PF00856(SET)PF05033(Pre-SET) | 5 | GLY A 153TYR A 193HIS A 220TYR A 261CYH A 289 | NoneSAM A 304 (-4.2A)SAM A 304 (-4.9A)SAM A 304 (-4.9A) ZN A 300 ( 2.3A) | 1.19A | 4ynpA-2r3aA:19.0 | 4ynpA-2r3aA:28.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r3a | HISTONE-LYSINEN-METHYLTRANSFERASESUV39H2 (Homo sapiens) |
PF00856(SET)PF05033(Pre-SET) | 6 | TYR A 193HIS A 220TYR A 261CYH A 287LYS A 288CYH A 289 | SAM A 304 (-4.2A)SAM A 304 (-4.9A)SAM A 304 (-4.9A) ZN A 300 ( 2.3A)None ZN A 300 ( 2.3A) | 0.86A | 4ynpA-2r3aA:19.0 | 4ynpA-2r3aA:28.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w5z | HISTONE-LYSINEN-METHYLTRANSFERASEHRX (Homo sapiens) |
PF00856(SET) | 5 | GLY A3840TYR A3883HIS A3907TYR A3944CYH A3957 | SAH A4971 ( 3.7A)NoneSAH A4971 (-4.7A)SAH A4971 (-4.9A) ZN A4970 ( 2.3A) | 1.45A | 4ynpA-2w5zA:14.7 | 4ynpA-2w5zA:27.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w5z | HISTONE-LYSINEN-METHYLTRANSFERASEHRX (Homo sapiens) |
PF00856(SET) | 6 | GLY A3840TYR A3883HIS A3907TYR A3944CYH A3957CYH A3959 | SAH A4971 ( 3.7A)NoneSAH A4971 (-4.7A)SAH A4971 (-4.9A) ZN A4970 ( 2.3A) ZN A4970 (-2.3A) | 0.55A | 4ynpA-2w5zA:14.7 | 4ynpA-2w5zA:27.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w5z | HISTONE-LYSINEN-METHYLTRANSFERASEHRX (Homo sapiens) |
PF00856(SET) | 5 | GLY A3842TYR A3883HIS A3907TYR A3944CYH A3959 | NoneNoneSAH A4971 (-4.7A)SAH A4971 (-4.9A) ZN A4970 (-2.3A) | 1.34A | 4ynpA-2w5zA:14.7 | 4ynpA-2w5zA:27.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a71 | EXO-ARABINANASE (Penicilliumchrysogenum) |
no annotation | 5 | LYS A 183GLY A 182TYR A 109HIS A 203TYR A 187 | None | 1.49A | 4ynpA-3a71A:undetectable | 4ynpA-3a71A:20.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bo5 | HISTONE-LYSINEN-METHYLTRANSFERASESETMAR (Homo sapiens) |
PF00856(SET)PF05033(Pre-SET) | 6 | GLY A 138TYR A 178HIS A 210TYR A 248CYH A 273CYH A 275 | NoneSAH A 305 (-4.0A)NoneSAH A 305 (-4.9A) ZN A 304 ( 2.3A) ZN A 304 ( 2.3A) | 1.31A | 4ynpA-3bo5A:19.9 | 4ynpA-3bo5A:28.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bo5 | HISTONE-LYSINEN-METHYLTRANSFERASESETMAR (Homo sapiens) |
PF00856(SET)PF05033(Pre-SET) | 5 | GLY A 138TYR A 178HIS A 210TYR A 248CYH A 275 | NoneSAH A 305 (-4.0A)NoneSAH A 305 (-4.9A) ZN A 304 ( 2.3A) | 1.00A | 4ynpA-3bo5A:19.9 | 4ynpA-3bo5A:28.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bo5 | HISTONE-LYSINEN-METHYLTRANSFERASESETMAR (Homo sapiens) |
PF00856(SET)PF05033(Pre-SET) | 8 | LYS A 135GLY A 136TRP A 137TYR A 178HIS A 210TYR A 248CYH A 273CYH A 275 | NoneSAH A 305 (-3.8A)NoneSAH A 305 (-4.0A)NoneSAH A 305 (-4.9A) ZN A 304 ( 2.3A) ZN A 304 ( 2.3A) | 0.45A | 4ynpA-3bo5A:19.9 | 4ynpA-3bo5A:28.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3khy | PROPIONATE KINASE (Francisellatularensis) |
PF00871(Acetate_kinase) | 5 | GLY A 30TYR A 59CYH A 40LYS A 41ILE A 35 | None | 1.40A | 4ynpA-3khyA:undetectable | 4ynpA-3khyA:20.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n71 | HISTONE LYSINEMETHYLTRANSFERASESMYD1 (Mus musculus) |
PF00856(SET)PF01753(zf-MYND) | 5 | GLY A 16HIS A 206TYR A 252CYH A 274CYH A 276 | NoneNoneSFG A 491 (-4.8A) ZN A 497 (-2.2A) ZN A 497 (-2.5A) | 0.96A | 4ynpA-3n71A:6.0 | 4ynpA-3n71A:17.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n71 | HISTONE LYSINEMETHYLTRANSFERASESMYD1 (Mus musculus) |
PF00856(SET)PF01753(zf-MYND) | 5 | LYS A 17GLY A 16HIS A 206TYR A 252CYH A 274 | SFG A 491 (-4.7A)NoneNoneSFG A 491 (-4.8A) ZN A 497 (-2.2A) | 1.32A | 4ynpA-3n71A:6.0 | 4ynpA-3n71A:17.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n71 | HISTONE LYSINEMETHYLTRANSFERASESMYD1 (Mus musculus) |
PF00856(SET)PF01753(zf-MYND) | 5 | LYS A 17GLY A 18HIS A 206TYR A 252CYH A 274 | SFG A 491 (-4.7A)SFG A 491 ( 4.2A)NoneSFG A 491 (-4.8A) ZN A 497 (-2.2A) | 0.97A | 4ynpA-3n71A:6.0 | 4ynpA-3n71A:17.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n71 | HISTONE LYSINEMETHYLTRANSFERASESMYD1 (Mus musculus) |
PF00856(SET)PF01753(zf-MYND) | 5 | LYS A 17GLY A 18HIS A 206TYR A 252CYH A 274 | SFG A 491 (-4.7A)SFG A 491 ( 4.2A)NoneSFG A 491 (-4.8A) ZN A 497 (-2.2A) | 1.32A | 4ynpA-3n71A:6.0 | 4ynpA-3n71A:17.81 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ooi | HISTONE-LYSINEN-METHYLTRANSFERASE,H3 LYSINE-36 AND H4LYSINE-20 SPECIFIC (Homo sapiens) |
PF00856(SET) | 8 | GLY A 102TRP A 103TYR A 146HIS A 170TYR A 207CYH A 219LYS A 220CYH A 221 | SAM A 237 ( 3.7A)NoneSAM A 237 (-4.1A)SAM A 237 (-4.7A)None ZN A 232 ( 2.3A)None ZN A 232 (-2.3A) | 0.46A | 4ynpA-3ooiA:26.4 | 4ynpA-3ooiA:41.25 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ooi | HISTONE-LYSINEN-METHYLTRANSFERASE,H3 LYSINE-36 AND H4LYSINE-20 SPECIFIC (Homo sapiens) |
PF00856(SET) | 5 | GLY A 104TYR A 146HIS A 170TYR A 207CYH A 221 | NoneSAM A 237 (-4.1A)SAM A 237 (-4.7A)None ZN A 232 (-2.3A) | 0.97A | 4ynpA-3ooiA:26.4 | 4ynpA-3ooiA:41.25 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ooi | HISTONE-LYSINEN-METHYLTRANSFERASE,H3 LYSINE-36 AND H4LYSINE-20 SPECIFIC (Homo sapiens) |
PF00856(SET) | 5 | GLY A 104TYR A 146HIS A 170TYR A 207CYH A 221 | NoneSAM A 237 (-4.1A)SAM A 237 (-4.7A)None ZN A 232 (-2.3A) | 1.44A | 4ynpA-3ooiA:26.4 | 4ynpA-3ooiA:41.25 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ope | PROBABLEHISTONE-LYSINEN-METHYLTRANSFERASEASH1L (Homo sapiens) |
PF00856(SET) | 7 | GLY A2153TYR A2194HIS A2218TYR A2255CYH A2268CYH A2270ILE A2279 | NoneSAM A 7 (-3.4A)NoneNone ZN A 1 ( 2.5A) ZN A 1 (-2.7A)None | 1.39A | 4ynpA-3opeA:34.1 | 4ynpA-3opeA:97.79 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ope | PROBABLEHISTONE-LYSINEN-METHYLTRANSFERASEASH1L (Homo sapiens) |
PF00856(SET) | 5 | GLY A2153TYR A2194HIS A2218TYR A2255CYH A2270 | NoneSAM A 7 (-3.4A)NoneNone ZN A 1 (-2.7A) | 0.93A | 4ynpA-3opeA:34.1 | 4ynpA-3opeA:97.79 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ope | PROBABLEHISTONE-LYSINEN-METHYLTRANSFERASEASH1L (Homo sapiens) |
PF00856(SET) | 11 | LYS A2150GLY A2151TRP A2152ASP A2192TYR A2194HIS A2218TYR A2255CYH A2268LYS A2269CYH A2270ILE A2279 | NoneSAM A 7 (-3.4A)NoneSAM A 7 (-3.9A)SAM A 7 (-3.4A)NoneNone ZN A 1 ( 2.5A)None ZN A 1 (-2.7A)None | 0.51A | 4ynpA-3opeA:34.1 | 4ynpA-3opeA:97.79 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ope | PROBABLEHISTONE-LYSINEN-METHYLTRANSFERASEASH1L (Homo sapiens) |
PF00856(SET) | 7 | LYS A2150GLY A2151TRP A2152TYR A2194HIS A2218TYR A2255CYH A2270 | NoneSAM A 7 (-3.4A)NoneSAM A 7 (-3.4A)NoneNone ZN A 1 (-2.7A) | 1.42A | 4ynpA-3opeA:34.1 | 4ynpA-3opeA:97.79 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ope | PROBABLEHISTONE-LYSINEN-METHYLTRANSFERASEASH1L (Homo sapiens) |
PF00856(SET) | 9 | LYS A2150TRP A2152HIS A2193TYR A2194HIS A2218TYR A2255CYH A2268CYH A2270ILE A2279 | NoneNoneNoneSAM A 7 (-3.4A)NoneNone ZN A 1 ( 2.5A) ZN A 1 (-2.7A)None | 1.11A | 4ynpA-3opeA:34.1 | 4ynpA-3opeA:97.79 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4fmu | HISTONE-LYSINEN-METHYLTRANSFERASESETD2 (Homo sapiens) |
PF00856(SET) | 5 | GLY A1563TYR A1605HIS A1629CYH A1678CYH A1680 | None0UM A1804 (-4.2A)None ZN A1803 ( 2.2A) ZN A1803 (-2.2A) | 1.49A | 4ynpA-4fmuA:25.0 | 4ynpA-4fmuA:37.36 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4fmu | HISTONE-LYSINEN-METHYLTRANSFERASESETD2 (Homo sapiens) |
PF00856(SET) | 7 | LYS A1560GLY A1561TRP A1562TYR A1605HIS A1629CYH A1678CYH A1680 | None0UM A1804 (-3.5A)None0UM A1804 (-4.2A)None ZN A1803 ( 2.2A) ZN A1803 (-2.2A) | 0.44A | 4ynpA-4fmuA:25.0 | 4ynpA-4fmuA:37.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mwz | PHOSPHOETHANOLAMINEN-METHYLTRANSFERASE,PUTATIVE (Plasmodiumvivax) |
PF13649(Methyltransf_25) | 5 | GLY A 62ASP A 58TYR A 122LYS A 92ILE A 101 | SAM A 301 ( 3.8A)SAM A 301 ( 4.6A)NoneNoneNone | 1.33A | 4ynpA-4mwzA:undetectable | 4ynpA-4mwzA:21.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qeo | HISTONE-LYSINEN-METHYLTRANSFERASE,H3 LYSINE-9 SPECIFICSUVH4 (Arabidopsisthaliana) |
PF00856(SET)PF02182(SAD_SRA)PF05033(Pre-SET) | 7 | LYS A 456GLY A 457TRP A 458HIS A 552TYR A 593CYH A 612CYH A 614 | SAH A 801 (-4.7A)SAH A 801 (-3.6A)SAH A 801 (-4.9A)NoneNone ZN A 805 ( 2.4A) ZN A 805 ( 2.4A) | 0.51A | 4ynpA-4qeoA:17.2 | 4ynpA-4qeoA:18.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qeo | HISTONE-LYSINEN-METHYLTRANSFERASE,H3 LYSINE-9 SPECIFICSUVH4 (Arabidopsisthaliana) |
PF00856(SET)PF02182(SAD_SRA)PF05033(Pre-SET) | 7 | LYS A 456GLY A 457TYR A 493HIS A 552TYR A 593CYH A 612CYH A 614 | SAH A 801 (-4.7A)SAH A 801 (-3.6A)SAH A 801 (-4.0A)NoneNone ZN A 805 ( 2.4A) ZN A 805 ( 2.4A) | 0.46A | 4ynpA-4qeoA:17.2 | 4ynpA-4qeoA:18.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rt6 | HEME/HEMOPEXIN-BINDING PROTEIN (Haemophilusinfluenzae) |
PF05860(Haemagg_act) | 5 | GLY A 491ASP A 511TYR A 509LYS A 494ILE A 580 | None | 1.30A | 4ynpA-4rt6A:undetectable | 4ynpA-4rt6A:12.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z4p | HISTONE-LYSINEN-METHYLTRANSFERASE2D (Homo sapiens) |
PF00856(SET) | 5 | GLY A5408HIS A5539HIS A5475CYH A5525CYH A5527 | SAH A5602 (-3.6A)NoneNone ZN A5601 ( 2.2A) ZN A5601 ( 2.2A) | 0.95A | 4ynpA-4z4pA:16.7 | 4ynpA-4z4pA:23.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z4p | HISTONE-LYSINEN-METHYLTRANSFERASE2D (Homo sapiens) |
PF00856(SET) | 6 | GLY A5408TYR A5451HIS A5475TYR A5512CYH A5525CYH A5527 | SAH A5602 (-3.6A)SAH A5602 (-4.5A)NoneNone ZN A5601 ( 2.2A) ZN A5601 ( 2.2A) | 0.34A | 4ynpA-4z4pA:16.7 | 4ynpA-4z4pA:23.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z4p | HISTONE-LYSINEN-METHYLTRANSFERASE2D (Homo sapiens) |
PF00856(SET) | 5 | GLY A5410TYR A5451HIS A5475TYR A5512CYH A5527 | NoneSAH A5602 (-4.5A)NoneNone ZN A5601 ( 2.2A) | 1.00A | 4ynpA-4z4pA:16.7 | 4ynpA-4z4pA:23.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f59 | HISTONE-LYSINEN-METHYLTRANSFERASE2C (Homo sapiens) |
PF00856(SET) | 6 | GLY A4782TYR A4825HIS A4849TYR A4886CYH A4899CYH A4901 | SAH A5002 (-3.5A)SAH A5002 (-4.5A)SAH A5002 (-4.6A)None ZN A5001 ( 2.0A) ZN A5001 (-2.3A) | 0.50A | 4ynpA-5f59A:16.2 | 4ynpA-5f59A:24.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f59 | HISTONE-LYSINEN-METHYLTRANSFERASE2C (Homo sapiens) |
PF00856(SET) | 5 | GLY A4784TYR A4825HIS A4849TYR A4886CYH A4901 | NoneSAH A5002 (-4.5A)SAH A5002 (-4.6A)None ZN A5001 (-2.3A) | 1.47A | 4ynpA-5f59A:16.2 | 4ynpA-5f59A:24.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f6l | HISTONE-LYSINEN-METHYLTRANSFERASE2A (Homo sapiens) |
PF00856(SET) | 6 | GLY A3840TYR A3883HIS A3907TYR A3944CYH A3957CYH A3959 | SAH A4001 (-3.4A)NoneSAH A4001 (-4.9A)SAH A4001 (-4.9A) ZN A4002 ( 2.3A) ZN A4002 (-2.3A) | 0.45A | 4ynpA-5f6lA:16.3 | 4ynpA-5f6lA:24.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kjm | N-LYSINEMETHYLTRANSFERASESMYD2 (Homo sapiens) |
PF00856(SET)PF01753(zf-MYND) | 5 | GLY A 16HIS A 207TYR A 240CYH A 262CYH A 264 | NoneNone6TM A 502 ( 3.6A) ZN A 505 (-2.3A) ZN A 505 (-2.4A) | 1.03A | 4ynpA-5kjmA:6.5 | 4ynpA-5kjmA:20.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kjm | N-LYSINEMETHYLTRANSFERASESMYD2 (Homo sapiens) |
PF00856(SET)PF01753(zf-MYND) | 5 | LYS A 17GLY A 18HIS A 207TYR A 240CYH A 262 | NoneSAM A 501 ( 4.1A)None6TM A 502 ( 3.6A) ZN A 505 (-2.3A) | 1.17A | 4ynpA-5kjmA:6.5 | 4ynpA-5kjmA:20.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kjm | N-LYSINEMETHYLTRANSFERASESMYD2 (Homo sapiens) |
PF00856(SET)PF01753(zf-MYND) | 5 | LYS A 17GLY A 18HIS A 207TYR A 240CYH A 262 | NoneSAM A 501 ( 4.1A)None6TM A 502 ( 3.6A) ZN A 505 (-2.3A) | 1.37A | 4ynpA-5kjmA:6.5 | 4ynpA-5kjmA:20.23 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5lsu | HISTONE-LYSINEN-METHYLTRANSFERASENSD2 (Homo sapiens) |
PF00856(SET) | 7 | GLY A1074TRP A1075TYR A1118HIS A1142TYR A1179CYH A1191CYH A1193 | SAM A1304 ( 3.2A)NoneSAM A1304 (-3.8A)SAM A1304 (-4.6A)SAM A1304 (-4.1A) ZN A1301 ( 2.3A) ZN A1301 (-2.3A) | 0.39A | 4ynpA-5lsuA:27.2 | 4ynpA-5lsuA:36.58 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5lsu | HISTONE-LYSINEN-METHYLTRANSFERASENSD2 (Homo sapiens) |
PF00856(SET) | 6 | GLY A1074TRP A1075TYR A1118HIS A1142TYR A1179CYH A1193 | SAM A1304 ( 3.2A)NoneSAM A1304 (-3.8A)SAM A1304 (-4.6A)SAM A1304 (-4.1A) ZN A1301 (-2.3A) | 1.37A | 4ynpA-5lsuA:27.2 | 4ynpA-5lsuA:36.58 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5lsu | HISTONE-LYSINEN-METHYLTRANSFERASENSD2 (Homo sapiens) |
PF00856(SET) | 5 | GLY A1076TYR A1118HIS A1142TYR A1179CYH A1193 | SAM A1304 ( 4.6A)SAM A1304 (-3.8A)SAM A1304 (-4.6A)SAM A1304 (-4.1A) ZN A1301 (-2.3A) | 0.99A | 4ynpA-5lsuA:27.2 | 4ynpA-5lsuA:36.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5teg | N-LYSINEMETHYLTRANSFERASEKMT5A (Homo sapiens) |
PF00856(SET) | 5 | LYS A 226GLY A 227TYR A 271HIS A 299TYR A 336 | SAM A 401 (-4.6A)SAM A 401 ( 4.0A)SAM A 401 (-4.1A)NoneSAM A 401 (-4.8A) | 0.44A | 4ynpA-5tegA:14.2 | 4ynpA-5tegA:22.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tuy | HISTONE-LYSINEN-METHYLTRANSFERASEEHMT2 (Homo sapiens) |
PF00856(SET)PF05033(Pre-SET) | 7 | GLY A1049TRP A1050TYR A1085HIS A1113TYR A1154CYH A1168CYH A1170 | SAM A1505 ( 3.9A)NoneSAM A1505 (-4.0A)SAM A1505 (-4.7A)SAM A1505 (-4.9A) ZN A1504 (-2.2A) ZN A1504 (-2.2A) | 0.47A | 4ynpA-5tuyA:18.0 | 4ynpA-5tuyA:28.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tuy | HISTONE-LYSINEN-METHYLTRANSFERASEEHMT2 (Homo sapiens) |
PF00856(SET)PF05033(Pre-SET) | 6 | GLY A1049TRP A1050TYR A1085HIS A1113TYR A1154CYH A1170 | SAM A1505 ( 3.9A)NoneSAM A1505 (-4.0A)SAM A1505 (-4.7A)SAM A1505 (-4.9A) ZN A1504 (-2.2A) | 1.39A | 4ynpA-5tuyA:18.0 | 4ynpA-5tuyA:28.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tuy | HISTONE-LYSINEN-METHYLTRANSFERASEEHMT2 (Homo sapiens) |
PF00856(SET)PF05033(Pre-SET) | 5 | GLY A1051TYR A1085HIS A1113TYR A1154CYH A1170 | NoneSAM A1505 (-4.0A)SAM A1505 (-4.7A)SAM A1505 (-4.9A) ZN A1504 (-2.2A) | 1.09A | 4ynpA-5tuyA:18.0 | 4ynpA-5tuyA:28.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tuy | HISTONE-LYSINEN-METHYLTRANSFERASEEHMT2 (Homo sapiens) |
PF00856(SET)PF05033(Pre-SET) | 5 | GLY A1051TYR A1085HIS A1113TYR A1154CYH A1170 | NoneSAM A1505 (-4.0A)SAM A1505 (-4.7A)SAM A1505 (-4.9A) ZN A1504 (-2.2A) | 1.46A | 4ynpA-5tuyA:18.0 | 4ynpA-5tuyA:28.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vsd | HISTONE-LYSINEN-METHYLTRANSFERASEEHMT1 (Homo sapiens) |
PF00856(SET)PF05033(Pre-SET) | 7 | GLY A1137TRP A1138TYR A1173HIS A1201TYR A1242CYH A1256CYH A1258 | SAM A3001 (-3.6A)NoneSAM A3001 (-4.0A)SAM A3001 (-4.6A)SAM A3001 (-4.8A) ZN A3005 ( 2.4A) ZN A3005 (-2.3A) | 0.55A | 4ynpA-5vsdA:18.1 | 4ynpA-5vsdA:29.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vsd | HISTONE-LYSINEN-METHYLTRANSFERASEEHMT1 (Homo sapiens) |
PF00856(SET)PF05033(Pre-SET) | 6 | GLY A1137TRP A1138TYR A1173HIS A1201TYR A1242CYH A1258 | SAM A3001 (-3.6A)NoneSAM A3001 (-4.0A)SAM A3001 (-4.6A)SAM A3001 (-4.8A) ZN A3005 (-2.3A) | 1.35A | 4ynpA-5vsdA:18.1 | 4ynpA-5vsdA:29.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vsd | HISTONE-LYSINEN-METHYLTRANSFERASEEHMT1 (Homo sapiens) |
PF00856(SET)PF05033(Pre-SET) | 5 | GLY A1139TYR A1173HIS A1201TYR A1242CYH A1258 | NoneSAM A3001 (-4.0A)SAM A3001 (-4.6A)SAM A3001 (-4.8A) ZN A3005 (-2.3A) | 1.03A | 4ynpA-5vsdA:18.1 | 4ynpA-5vsdA:29.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vsd | HISTONE-LYSINEN-METHYLTRANSFERASEEHMT1 (Homo sapiens) |
PF00856(SET)PF05033(Pre-SET) | 5 | GLY A1139TYR A1173HIS A1201TYR A1242CYH A1258 | NoneSAM A3001 (-4.0A)SAM A3001 (-4.6A)SAM A3001 (-4.8A) ZN A3005 (-2.3A) | 1.43A | 4ynpA-5vsdA:18.1 | 4ynpA-5vsdA:29.30 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6cen | HISTONE-LYSINEN-METHYLTRANSFERASENSD3 (Homo sapiens) |
no annotation | 7 | GLY A1156TRP A1157TYR A1200HIS A1224TYR A1261CYH A1273CYH A1275 | SAM A1301 (-3.6A)NoneSAM A1301 (-3.9A)NoneSAM A1301 (-4.9A) ZN A1304 ( 2.3A) ZN A1304 (-2.3A) | 0.38A | 4ynpA-6cenA:26.1 | 4ynpA-6cenA:41.03 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6cen | HISTONE-LYSINEN-METHYLTRANSFERASENSD3 (Homo sapiens) |
no annotation | 6 | GLY A1156TRP A1157TYR A1200HIS A1224TYR A1261CYH A1275 | SAM A1301 (-3.6A)NoneSAM A1301 (-3.9A)NoneSAM A1301 (-4.9A) ZN A1304 (-2.3A) | 1.48A | 4ynpA-6cenA:26.1 | 4ynpA-6cenA:41.03 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6cen | HISTONE-LYSINEN-METHYLTRANSFERASENSD3 (Homo sapiens) |
no annotation | 6 | GLY A1158TYR A1200HIS A1224TYR A1261CYH A1273CYH A1275 | NoneSAM A1301 (-3.9A)NoneSAM A1301 (-4.9A) ZN A1304 ( 2.3A) ZN A1304 (-2.3A) | 1.37A | 4ynpA-6cenA:26.1 | 4ynpA-6cenA:41.03 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6cen | HISTONE-LYSINEN-METHYLTRANSFERASENSD3 (Homo sapiens) |
no annotation | 5 | GLY A1158TYR A1200HIS A1224TYR A1261CYH A1275 | NoneSAM A1301 (-3.9A)NoneSAM A1301 (-4.9A) ZN A1304 (-2.3A) | 1.05A | 4ynpA-6cenA:26.1 | 4ynpA-6cenA:41.03 |