SIMILAR PATTERNS OF AMINO ACIDS FOR 4YND_A_SAMA505_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)

Filter list by:

	Hit	Macromolecule/ Organism	Pfam	Res.	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2h21	RIBULOSE-1,5 BISPHOSPHATE CARBOXYLASE/OXYGENAS E (Pisum sativum)	PF00856 (SET) PF09273 (Rubis-subs-bind)	5	ASN A 242 HIS A 243 TYR A 287 TYR A 300 PHE A 302	SAM A 801 (-2.9A) SAM A 801 (-4.9A) SAM A 801 (-4.8A) None SAM A 801 (-3.9A)	0.57A	4yndA-2h21A: 2.7	4yndA-2h21A: 23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3n71	HISTONE LYSINE METHYLTRANSFERASE SMYD1 (Mus musculus)	PF00856 (SET) PF01753 (zf-MYND)	9	LYS A 17 ARG A 19 HIS A 135 ASN A 180 ASN A 205 HIS A 206 TYR A 252 TYR A 270 PHE A 272	SFG A 491 (-4.7A) SFG A 491 (-3.9A) SFG A 491 (-3.8A) SFG A 491 (-4.3A) SFG A 491 (-3.3A) None SFG A 491 (-4.8A) None SFG A 491 (-3.7A)	0.64A	4yndA-3n71A: 37.6	4yndA-3n71A: 29.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3rc0	N-LYSINE METHYLTRANSFERASE SETD6 (Homo sapiens)	PF00856 (SET) PF09273 (Rubis-subs-bind)	5	ASN A 251 HIS A 252 TYR A 285 TYR A 297 PHE A 299	SAM A 484 (-3.1A) None SAM A 484 (-4.8A) None SAM A 484 (-3.5A)	0.44A	4yndA-3rc0A: 13.4	4yndA-3rc0A: 24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3rc0	N-LYSINE METHYLTRANSFERASE SETD6 (Homo sapiens)	PF00856 (SET) PF09273 (Rubis-subs-bind)	5	HIS A 155 HIS A 252 TYR A 285 TYR A 297 PHE A 299	None None SAM A 484 (-4.8A) None SAM A 484 (-3.5A)	1.16A	4yndA-3rc0A: 13.4	4yndA-3rc0A: 24.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5kjm	N-LYSINE METHYLTRANSFERASE SMYD2 (Homo sapiens)	PF00856 (SET) PF01753 (zf-MYND)	10	LYS A 17 ARG A 19 HIS A 137 CYH A 181 ASN A 182 ASN A 206 HIS A 207 TYR A 240 TYR A 258 PHE A 260	None SAM A 501 (-3.7A) SAM A 501 (-3.9A) SAM A 501 ( 3.4A) SAM A 501 ( 3.8A) SAM A 501 (-3.2A) None 6TM A 502 ( 3.6A) 6TM A 502 ( 4.2A) SAM A 501 (-3.6A)	0.26A	4yndA-5kjmA: 57.7	4yndA-5kjmA: 99.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5teg	N-LYSINE METHYLTRANSFERASE KMT5A (Homo sapiens)	PF00856 (SET)	5	LYS A 226 ARG A 228 ASN A 298 HIS A 299 TYR A 336	SAM A 401 (-4.6A) SAM A 401 (-3.7A) SAM A 401 (-3.2A) None SAM A 401 (-4.8A)	0.67A	4yndA-5tegA: 7.9	4yndA-5tegA: 14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5xxg	- (-)	no annotation	7	CYH A 180 ASN A 181 ASN A 205 HIS A 206 TYR A 239 TYR A 257 PHE A 259	SAM A 502 (-4.1A) SAM A 502 ( 4.1A) SAM A 502 (-3.1A) None 8HR A 501 ( 4.0A) None SAM A 502 (-3.5A)	0.45A	4yndA-5xxgA: 43.6	4yndA-5xxgA: undetectable

[["4YND_A_SAMA505_0","2h21","Pisum sativum","RIBULOSE-1,5 BISPHOSPHATE CARBOXYLASE\/OXYGENASE","PF00856(SET);PF09273(Rubis-subs-bind)",5,"ASN A 242;HIS A 243;TYR A 287;TYR A 300;PHE A 302","SAM A 801 (-2.9A);SAM A 801 (-4.9A);SAM A 801 (-4.8A);None;SAM A 801 (-3.9A)","0.57A","4yndA-2h21A:2.7","4yndA-2h21A:23.63"],["4YND_A_SAMA505_0","3n71","Mus musculus","HISTONE LYSINE METHYLTRANSFERASE SMYD1","PF00856(SET);PF01753(zf-MYND)",9,"LYS A  17;ARG A  19;HIS A 135;ASN A 180;ASN A 205;HIS A 206;TYR A 252;TYR A 270;PHE A 272","SFG A 491 (-4.7A);SFG A 491 (-3.9A);SFG A 491 (-3.8A);SFG A 491 (-4.3A);SFG A 491 (-3.3A);None;SFG A 491 (-4.8A);None;SFG A 491 (-3.7A)","0.64A","4yndA-3n71A:37.6","4yndA-3n71A:29.78"],["4YND_A_SAMA505_0","3rc0","Homo sapiens","N-LYSINE METHYLTRANSFERASE SETD6","PF00856(SET);PF09273(Rubis-subs-bind)",5,"ASN A 251;HIS A 252;TYR A 285;TYR A 297;PHE A 299","SAM A 484 (-3.1A);None;SAM A 484 (-4.8A);None;SAM A 484 (-3.5A)","0.44A","4yndA-3rc0A:13.4","4yndA-3rc0A:24.32"],["4YND_A_SAMA505_0","3rc0","Homo sapiens","N-LYSINE METHYLTRANSFERASE SETD6","PF00856(SET);PF09273(Rubis-subs-bind)",5,"HIS A 155;HIS A 252;TYR A 285;TYR A 297;PHE A 299","None;None;SAM A 484 (-4.8A);None;SAM A 484 (-3.5A)","1.16A","4yndA-3rc0A:13.4","4yndA-3rc0A:24.32"],["4YND_A_SAMA505_0","5kjm","Homo sapiens","N-LYSINE METHYLTRANSFERASE SMYD2","PF00856(SET);PF01753(zf-MYND)",10,"LYS A  17;ARG A  19;HIS A 137;CYH A 181;ASN A 182;ASN A 206;HIS A 207;TYR A 240;TYR A 258;PHE A 260","None;SAM A 501 (-3.7A);SAM A 501 (-3.9A);SAM A 501 ( 3.4A);SAM A 501 ( 3.8A);SAM A 501 (-3.2A);None;6TM A 502 ( 3.6A);6TM A 502 ( 4.2A);SAM A 501 (-3.6A)","0.26A","4yndA-5kjmA:57.7","4yndA-5kjmA:99.77"],["4YND_A_SAMA505_0","5teg","Homo sapiens","N-LYSINE METHYLTRANSFERASE KMT5A","PF00856(SET)",5,"LYS A 226;ARG A 228;ASN A 298;HIS A 299;TYR A 336","SAM A 401 (-4.6A);SAM A 401 (-3.7A);SAM A 401 (-3.2A);None;SAM A 401 (-4.8A)","0.67A","4yndA-5tegA:7.9","4yndA-5tegA:14.25"],["4YND_A_SAMA505_0","5xxg","-","-","no annotation",7,"CYH A 180;ASN A 181;ASN A 205;HIS A 206;TYR A 239;TYR A 257;PHE A 259","SAM A 502 (-4.1A);SAM A 502 ( 4.1A);SAM A 502 (-3.1A);None;8HR A 501 ( 4.0A);None;SAM A 502 (-3.5A)","0.45A","4yndA-5xxgA:43.6","4yndA-5xxgA:undetectable"]]