SIMILAR PATTERNS OF AMINO ACIDS FOR 4YMG_B_SAMB1001_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4k PROTEIN (ORNITHINE
DECARBOXYLASE)

(Lactobacillus
sp. 30A) 		PF01276
(OKR_DC_1)
PF03709
(OKR_DC_1_N)
PF03711
(OKR_DC_1_C) 		3 SER A 198
GLU A 532
GLU A 547
 PLP  A 955 (-3.9A)
None
None
 0.77A 4ymgB-1c4kA:
undetectable		 4ymgB-1c4kA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
PF03173
(CHB_HEX)
PF03174
(CHB_HEX_C) 		3 SER A 488
GLU A 461
GLU A 473
 None
 0.74A 4ymgB-1c7tA:
0.7		 4ymgB-1c7tA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eq1 APOLIPOPHORIN-III

(Manduca sexta) 		PF07464
(ApoLp-III) 		3 SER A  60
GLU A 118
GLU A  89
 None
 0.78A 4ymgB-1eq1A:
undetectable		 4ymgB-1eq1A:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8k ARSENITE OXIDASE
ARSENITE OXIDASE

(Alcaligenes
faecalis;
Alcaligenes
faecalis) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF00355
(Rieske) 		3 SER B  72
GLU A 764
GLU A 237
 None
 0.64A 4ymgB-1g8kB:
undetectable		 4ymgB-1g8kB:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htr GASTRICSIN
PROGASTRICSIN (PRO
SEGMENT)

(Homo sapiens;
Homo sapiens) 		PF00026
(Asp)
PF07966
(A1_Propeptide) 		3 SER P  12
GLU B 289
GLU B 241
 None
 0.77A 4ymgB-1htrP:
undetectable		 4ymgB-1htrP:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i9a ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE

(Escherichia
coli) 		PF00293
(NUDIX) 		3 SER A 159
GLU A  87
GLU A  74
 None
 0.87A 4ymgB-1i9aA:
undetectable		 4ymgB-1i9aA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k3e CEST

(Escherichia
coli) 		PF05932
(CesT) 		3 SER A 146
GLU A   6
GLU A  14
 None
 0.79A 4ymgB-1k3eA:
undetectable		 4ymgB-1k3eA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kig FACTOR XA

(Bos taurus) 		PF00089
(Trypsin) 		3 SER H 139
GLU H  24
GLU H  77
 None
 0.86A 4ymgB-1kigH:
undetectable		 4ymgB-1kigH:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m6y S-ADENOSYL-METHYLTRA
NSFERASE MRAW

(Thermotoga
maritima) 		PF01795
(Methyltransf_5) 		3 SER A 134
GLU A 220
GLU A 156
 None
 0.60A 4ymgB-1m6yA:
13.8		 4ymgB-1m6yA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ow0 IG ALPHA-1 CHAIN C
REGION
IMMUNOGLOBULIN ALPHA
FC RECEPTOR

(Homo sapiens;
Homo sapiens) 		PF00047
(ig)
PF07654
(C1-set)
no annotation 		3 SER C  91
GLU C  49
GLU A 389
 None
None
GAL  A 506 (-4.1A)
 0.85A 4ymgB-1ow0C:
undetectable		 4ymgB-1ow0C:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qmo MANNOSE BINDING
LECTIN, FRIL

(Lablab
purpureus) 		PF00139
(Lectin_legB) 		3 SER E 132
GLU E 138
GLU E 232
 None
MN  A 301 (-3.1A)
None
 0.82A 4ymgB-1qmoE:
undetectable		 4ymgB-1qmoE:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szq 2-METHYLCITRATE
DEHYDRATASE

(Escherichia
coli) 		PF03972
(MmgE_PrpD) 		3 SER A 128
GLU A 185
GLU A  27
 None
 0.60A 4ymgB-1szqA:
undetectable		 4ymgB-1szqA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT

(Klebsiella
oxytoca) 		PF02286
(Dehydratase_LU) 		3 SER A 118
GLU A  22
GLU A  25
 None
 0.70A 4ymgB-1uc4A:
2.2		 4ymgB-1uc4A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v0f ENDO-ALPHA-SIALIDASE

(Enterobacteria
phage K1F) 		PF12217
(End_beta_propel)
PF12218
(End_N_terminal)
PF12219
(End_tail_spike) 		3 SER A 605
GLU A 651
GLU A 721
 SER  A 605 ( 0.0A)
GLU  A 651 ( 0.6A)
GLU  A 721 ( 0.6A)
 0.87A 4ymgB-1v0fA:
undetectable		 4ymgB-1v0fA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8p [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 3
DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE
COMPONENT OF
PYRUVATE
DEHYDROGENASE
COMPLEX

(Homo sapiens;
Homo sapiens) 		PF02518
(HATPase_c)
PF10436
(BCDHK_Adom3)
PF00364
(Biotin_lipoyl) 		3 SER A 160
GLU A  63
GLU B 179
 None
 0.63A 4ymgB-1y8pA:
undetectable		 4ymgB-1y8pA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3z DIALKYLGLYCINE
DECARBOXYLASE

(Burkholderia
cepacia) 		PF00202
(Aminotran_3) 		3 SER A  84
GLU A  70
GLU A  63
 None
 0.74A 4ymgB-1z3zA:
undetectable		 4ymgB-1z3zA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zb7 NEUROTOXIN

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		3 SER A 174
GLU A 268
GLU A 357
 None
FLC  A 501 ( 3.0A)
None
 0.75A 4ymgB-1zb7A:
undetectable		 4ymgB-1zb7A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aqx PREDICTED: INOSITOL
1,4,5-TRISPHOSPHATE
3-KINASE B

(Mus musculus) 		PF03770
(IPK) 		3 SER A 923
GLU A 797
GLU A 751
 None
 0.84A 4ymgB-2aqxA:
undetectable		 4ymgB-2aqxA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2arh HYPOTHETICAL PROTEIN
AQ_1966

(Aquifex
aeolicus) 		PF06557
(DUF1122) 		3 SER A  17
GLU A 125
GLU A 106
 None
 0.84A 4ymgB-2arhA:
undetectable		 4ymgB-2arhA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bkl PROLYL ENDOPEPTIDASE

(Myxococcus
xanthus) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		3 SER A  71
GLU A  92
GLU A 646
 None
 0.77A 4ymgB-2bklA:
undetectable		 4ymgB-2bklA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2a ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B

(Staphylococcus
aureus) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N) 		3 SER B 172
GLU B 328
GLU B 306
 None
 0.86A 4ymgB-2f2aB:
undetectable		 4ymgB-2f2aB:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fkb PUTATIVE NUDIX
HYDROLASE YFCD

(Escherichia
coli) 		PF00293
(NUDIX) 		3 SER A 124
GLU A  92
GLU A  79
 None
 0.87A 4ymgB-2fkbA:
undetectable		 4ymgB-2fkbA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hmf PROBABLE
ASPARTOKINASE

(Methanocaldococcus
jannaschii) 		PF00696
(AA_kinase)
PF01842
(ACT)
PF13840
(ACT_7) 		3 SER A 148
GLU A 155
GLU A 103
 None
 0.87A 4ymgB-2hmfA:
4.5		 4ymgB-2hmfA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ijx DNA POLYMERASE
SLIDING CLAMP A

(Sulfolobus
solfataricus) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		3 SER A 217
GLU A 123
GLU A  35
 None
EDO  A 609 ( 4.0A)
None
 0.77A 4ymgB-2ijxA:
undetectable		 4ymgB-2ijxA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipp CATHEPSIN B

(Homo sapiens) 		PF00112
(Peptidase_C1) 		3 SER B 220
GLU B  53
GLU B 133
 None
 0.79A 4ymgB-2ippB:
undetectable		 4ymgB-2ippB:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2plj LYSINE/ORNITHINE
DECARBOXYLASE

(Vibrio
vulnificus) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		3 SER A 370
GLU A  91
GLU A 270
 None
None
P3T  A 501 (-3.7A)
 0.76A 4ymgB-2pljA:
undetectable		 4ymgB-2pljA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pnc COPPER AMINE
OXIDASE, LIVER
ISOZYME

(Bos taurus) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		3 SER A 386
GLU A 361
GLU A 638
 None
 0.80A 4ymgB-2pncA:
undetectable		 4ymgB-2pncA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qgh DIAMINOPIMELATE
DECARBOXYLASE

(Helicobacter
pylori) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		3 SER A 360
GLU A  71
GLU A 259
 None
None
PLP  A 406 (-3.7A)
 0.81A 4ymgB-2qghA:
undetectable		 4ymgB-2qghA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qve TYROSINE AMINOMUTASE

(Streptomyces
globisporus) 		PF00221
(Lyase_aromatic) 		3 SER A 487
GLU A 279
GLU A 249
 None
 0.71A 4ymgB-2qveA:
undetectable		 4ymgB-2qveA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE

(Escherichia
coli) 		PF00596
(Aldolase_II) 		3 SER A 243
GLU A 232
GLU A  27
 None
 0.75A 4ymgB-2v9iA:
undetectable		 4ymgB-2v9iA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vbk TAILSPIKE-PROTEIN

(Shigella virus
Sf6) 		PF12708
(Pectate_lyase_3) 		3 SER A 365
GLU A 409
GLU A 345
 None
 0.87A 4ymgB-2vbkA:
undetectable		 4ymgB-2vbkA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vr5 GLYCOGEN OPERON
PROTEIN GLGX

(Sulfolobus
solfataricus) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		3 SER A 463
GLU A 441
GLU A 435
 None
 0.82A 4ymgB-2vr5A:
undetectable		 4ymgB-2vr5A:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wya HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		3 SER A 322
GLU A 344
GLU A 236
 None
 0.61A 4ymgB-2wyaA:
undetectable		 4ymgB-2wyaA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ze0 ALPHA-GLUCOSIDASE

(Geobacillus sp.
HTA-462) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		3 SER A 330
GLU A 445
GLU A  42
 None
 0.88A 4ymgB-2ze0A:
undetectable		 4ymgB-2ze0A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3axi OLIGO-1,6-GLUCOSIDAS
E IMA1

(Saccharomyces
cerevisiae) 		PF00128
(Alpha-amylase) 		3 SER A 180
GLU A 421
GLU A 146
 None
 0.87A 4ymgB-3axiA:
undetectable		 4ymgB-3axiA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwq PARA FAMILY
CHROMOSOME
PARTITIONING PROTEIN

(Synechocystis
sp. PCC 6803) 		PF01656
(CbiA) 		3 SER A  41
GLU A  58
GLU A  80
 ADP  A 301 ( 4.3A)
None
None
 0.76A 4ymgB-3cwqA:
undetectable		 4ymgB-3cwqA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cx3 LIPOPROTEIN

(Streptococcus
pneumoniae) 		PF01297
(ZnuA) 		3 SER A  67
GLU A 260
GLU A 269
 None
 0.86A 4ymgB-3cx3A:
undetectable		 4ymgB-3cx3A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d46 PUTATIVE GALACTONATE
DEHYDRATASE

(Salmonella
enterica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 SER A  50
GLU A 253
GLU A 349
 None
None
TLA  A 502 (-2.8A)
 0.68A 4ymgB-3d46A:
undetectable		 4ymgB-3d46A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dni DEOXYRIBONUCLEASE I

(Bos taurus) 		PF03372
(Exo_endo_phos) 		3 SER A 250
GLU A  78
GLU A 143
 None
 0.73A 4ymgB-3dniA:
2.6		 4ymgB-3dniA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9m OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY

(Enterococcus
faecalis) 		PF01408
(GFO_IDH_MocA) 		3 SER A 166
GLU A 311
GLU A 121
 None
 0.74A 4ymgB-3e9mA:
4.2		 4ymgB-3e9mA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fo8 TAIL SHEATH PROTEIN
GP18

(Escherichia
virus T4) 		PF17481
(Phage_sheath_1N) 		3 SER D 320
GLU D 357
GLU D 229
 None
 0.86A 4ymgB-3fo8D:
undetectable		 4ymgB-3fo8D:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxg RHAMNONATE
DEHYDRATASE

(Fusarium
graminearum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 SER A  46
GLU A 248
GLU A 344
 None
 0.69A 4ymgB-3fxgA:
undetectable		 4ymgB-3fxgA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwf CYCLOHEXANONE
MONOOXYGENASE

(Rhodococcus sp.
HI-31) 		PF00743
(FMO-like) 		3 SER A  77
GLU A 442
GLU A  30
 None
 0.75A 4ymgB-3gwfA:
undetectable		 4ymgB-3gwfA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Schizosaccharomyces
pombe) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		3 SER B 535
GLU B 681
GLU B 584
 None
 0.85A 4ymgB-3h0gB:
undetectable		 4ymgB-3h0gB:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k0s DNA MISMATCH REPAIR
PROTEIN MUTS

(Escherichia
coli) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		3 SER A 151
GLU A 177
GLU A  88
 None
 0.85A 4ymgB-3k0sA:
undetectable		 4ymgB-3k0sA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kje CO
DEHYDROGENASE/ACETYL
-COA SYNTHASE
COMPLEX, ACCESSORY
PROTEIN COOC

(Carboxydothermus
hydrogenoformans) 		PF01656
(CbiA) 		3 SER A 167
GLU A 175
GLU A 252
 None
 0.84A 4ymgB-3kjeA:
undetectable		 4ymgB-3kjeA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ln6 GLUTATHIONE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
GSHAB

(Streptococcus
agalactiae) 		PF01071
(GARS_A)
PF04262
(Glu_cys_ligase) 		3 SER A 661
GLU A 572
GLU A 565
 SO4  A 751 (-3.1A)
None
None
 0.80A 4ymgB-3ln6A:
undetectable		 4ymgB-3ln6A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lp8 PHOSPHORIBOSYLAMINE-
GLYCINE LIGASE

(Ehrlichia
chaffeensis) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		3 SER A  79
GLU A 100
GLU A 292
 None
 0.59A 4ymgB-3lp8A:
undetectable		 4ymgB-3lp8A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mv3 COATOMER SUBUNIT
ALPHA

(Saccharomyces
cerevisiae) 		PF06957
(COPI_C) 		3 SER A1188
GLU A1177
GLU A1053
 None
 0.70A 4ymgB-3mv3A:
undetectable		 4ymgB-3mv3A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o14 ANTI-ECFSIGMA
FACTOR, CHRR

(Marinobacter
hydrocarbonoclasticus) 		PF12973
(Cupin_7) 		3 SER A  23
GLU A  64
GLU A  76
 NIO  A 300 ( 4.4A)
ZN  A 250 (-1.8A)
None
 0.67A 4ymgB-3o14A:
undetectable		 4ymgB-3o14A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o59 DNA POLYMERASE II
LARGE SUBUNIT

(Pyrococcus
horikoshii) 		PF03833
(PolC_DP2) 		3 SER X 136
GLU X 220
GLU X 190
 None
 0.77A 4ymgB-3o59X:
undetectable		 4ymgB-3o59X:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pih UVRABC SYSTEM
PROTEIN A

(Thermotoga
maritima) 		PF00005
(ABC_tran) 		3 SER A 466
GLU A 865
GLU A 526
 None
 0.62A 4ymgB-3pihA:
undetectable		 4ymgB-3pihA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pih UVRABC SYSTEM
PROTEIN A

(Thermotoga
maritima) 		PF00005
(ABC_tran) 		3 SER A 621
GLU A 865
GLU A 526
 PPV  A1001 (-2.9A)
None
None
 0.87A 4ymgB-3pihA:
undetectable		 4ymgB-3pihA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qlt GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 2

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		3 SER A  83
GLU A  22
GLU A 202
 None
 0.72A 4ymgB-3qltA:
5.1		 4ymgB-3qltA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3shd PHOSPHATASE NUDJ

(Escherichia
coli) 		PF00293
(NUDIX) 		3 SER A 120
GLU A  55
GLU A  39
 None
SO4  A 157 ( 2.4A)
MN  A 155 ( 4.7A)
 0.74A 4ymgB-3shdA:
undetectable		 4ymgB-3shdA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3skv SSFX3

(Streptomyces
sp. SF2575) 		PF13472
(Lipase_GDSL_2) 		3 SER A 351
GLU A 322
GLU A 279
 None
 0.70A 4ymgB-3skvA:
4.2		 4ymgB-3skvA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t2c FRUCTOSE-1,6-BISPHOS
PHATE
ALDOLASE/PHOSPHATASE

(Pyrobaculum
neutrophilum) 		PF01950
(FBPase_3) 		3 SER A  55
GLU A 220
GLU A 169
 None
 0.84A 4ymgB-3t2cA:
undetectable		 4ymgB-3t2cA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t7v METHYLORNITHINE
SYNTHASE PYLB

(Methanosarcina
barkeri) 		PF04055
(Radical_SAM) 		3 SER A 277
GLU A 171
GLU A 117
 MD0  A 993 (-2.6A)
SAM  A 992 (-2.8A)
None
 0.76A 4ymgB-3t7vA:
undetectable		 4ymgB-3t7vA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tj7 GBAA_1210 PROTEIN

(Bacillus
anthracis) 		PF01928
(CYTH) 		3 SER A 138
GLU A 125
GLU A   4
 None
 0.85A 4ymgB-3tj7A:
undetectable		 4ymgB-3tj7A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wx7 CHITIN
OLIGOSACCHARIDE
DEACETYLASE

(Vibrio
parahaemolyticus) 		PF01522
(Polysacc_deac_1) 		3 SER A  86
GLU A 292
GLU A  73
 None
 0.77A 4ymgB-3wx7A:
undetectable		 4ymgB-3wx7A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyj LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4C
NETRIN-G1

(Homo sapiens;
Homo sapiens) 		PF00560
(LRR_1)
PF07679
(I-set)
PF13306
(LRR_5)
PF13855
(LRR_8)
PF00053
(Laminin_EGF)
PF00055
(Laminin_N) 		3 SER B 228
GLU B 283
GLU A 223
 None
 0.86A 4ymgB-3zyjB:
undetectable		 4ymgB-3zyjB:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4awn DEOXYRIBONUCLEASE-1

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		3 SER A 250
GLU A  78
GLU A 143
 None
 0.77A 4ymgB-4awnA:
2.5		 4ymgB-4awnA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bs9 TRUD

(uncultured
Prochloron sp.
06037A) 		PF02624
(YcaO) 		3 SER A 561
GLU A 647
GLU A 430
 None
 0.84A 4ymgB-4bs9A:
undetectable		 4ymgB-4bs9A:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4by9 NOP5/NOP56 RELATED
PROTEIN
FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		PF01798
(Nop)
PF01269
(Fibrillarin) 		3 SER E  92
GLU E  47
GLU C 226
 None
 0.80A 4ymgB-4by9E:
11.9		 4ymgB-4by9E:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d0p COP9 SIGNALOSOME
COMPLEX SUBUNIT 4

(Homo sapiens) 		PF01399
(PCI) 		3 SER A 178
GLU A 133
GLU A 100
 None
 0.82A 4ymgB-4d0pA:
undetectable		 4ymgB-4d0pA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0a PROTEIN WNT-8

(Xenopus laevis) 		PF00110
(wnt) 		3 SER B 106
GLU B 201
GLU B  54
 None
 0.82A 4ymgB-4f0aB:
undetectable		 4ymgB-4f0aB:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f3l CIRCADIAN LOCOMOTER
OUTPUT CYCLES
PROTEIN KAPUT
BMAL1B

(Mus musculus;
Mus musculus) 		PF00010
(HLH)
PF00989
(PAS)
PF14598
(PAS_11)
PF00010
(HLH)
PF00989
(PAS)
PF14598
(PAS_11) 		3 SER B 211
GLU A 270
GLU A 108
 None
 0.79A 4ymgB-4f3lB:
undetectable		 4ymgB-4f3lB:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hiz ENDOSIALIDASE

(Enterobacteria
phage phi92) 		PF12217
(End_beta_propel)
PF12218
(End_N_terminal)
PF12219
(End_tail_spike) 		3 SER A 446
GLU A 492
GLU A 564
 None
 0.81A 4ymgB-4hizA:
undetectable		 4ymgB-4hizA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjh PHOSPHOMANNOMUTASE

(Brucella
melitensis) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		3 SER A 306
GLU A 287
GLU A 449
 IOD  A 505 ( 4.8A)
None
EDO  A 548 ( 4.9A)
 0.67A 4ymgB-4hjhA:
undetectable		 4ymgB-4hjhA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzh PROTHROMBIN

(Homo sapiens) 		PF00051
(Kringle)
PF00089
(Trypsin)
PF09396
(Thrombin_light) 		3 SER A 275
GLU A 305
GLU A 314
 None
 0.82A 4ymgB-4hzhA:
undetectable		 4ymgB-4hzhA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j57 THIOREDOXIN
REDUCTASE 2

(Plasmodium
falciparum) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 SER A 107
GLU A 274
GLU A 428
 None
 0.80A 4ymgB-4j57A:
2.3		 4ymgB-4j57A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jc8 HOPS COMPONENT VPS33

(Chaetomium
thermophilum) 		PF00995
(Sec1) 		3 SER A 540
GLU A 505
GLU A 508
 None
 0.81A 4ymgB-4jc8A:
2.7		 4ymgB-4jc8A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jjn HISTONE H2A.2
HISTONE H2B.2

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00125
(Histone)
PF16211
(Histone_H2A_C)
PF00125
(Histone) 		3 SER C  19
GLU D 116
GLU C  65
 None
 0.72A 4ymgB-4jjnC:
undetectable		 4ymgB-4jjnC:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l9g TRANSCRIPTIONAL
REGULATOR, PPSR

(Rhodobacter
sphaeroides) 		PF13188
(PAS_8) 		3 SER A  74
GLU A  65
GLU A  97
 None
 0.76A 4ymgB-4l9gA:
undetectable		 4ymgB-4l9gA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmh EXTRACELLULAR IRON
OXIDE RESPIRATORY
SYSTEM SURFACE
DECAHEME CYTOCHROME
C COMPONENT OMCA

(Shewanella
oneidensis) 		no annotation 3 SER A 263
GLU A 353
GLU A 102
 None
 0.75A 4ymgB-4lmhA:
undetectable		 4ymgB-4lmhA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lob POLYPRENYL
SYNTHETASE

(Acinetobacter
baumannii) 		PF00348
(polyprenyl_synt) 		3 SER A 280
GLU A 164
GLU A 293
 None
 0.78A 4ymgB-4lobA:
undetectable		 4ymgB-4lobA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ma5 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Francisella
tularensis) 		PF02222
(ATP-grasp) 		3 SER A 362
GLU A 213
GLU A 349
 None
 0.80A 4ymgB-4ma5A:
4.3		 4ymgB-4ma5A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4miv N-SULPHOGLUCOSAMINE
SULPHOHYDROLASE

(Homo sapiens) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		3 SER A  69
GLU A 140
GLU A 129
 FGP  A  70 ( 3.3A)
None
None
 0.61A 4ymgB-4mivA:
undetectable		 4ymgB-4mivA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mte ZINC UPTAKE
REGULATION PROTEIN

(Escherichia
coli) 		PF01475
(FUR) 		3 SER A  84
GLU A 111
GLU A 118
 None
ZN  A 202 (-2.2A)
None
 0.87A 4ymgB-4mteA:
undetectable		 4ymgB-4mteA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n4k HYDROXYLAMINE
OXIDOREDUCTASE

(Candidatus
Kuenenia
stuttgartiensis) 		PF13447
(Multi-haem_cyto) 		3 SER A 489
GLU A 469
GLU A 428
 None
 0.74A 4ymgB-4n4kA:
undetectable		 4ymgB-4n4kA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n4r LPS-ASSEMBLY PROTEIN
LPTD
LPS-ASSEMBLY
LIPOPROTEIN LPTE

(Salmonella
enterica;
Salmonella
enterica) 		PF04453
(OstA_C)
PF04390
(LptE) 		3 SER A 441
GLU B 153
GLU A 575
 None
 0.79A 4ymgB-4n4rA:
undetectable		 4ymgB-4n4rA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o89 RNA 3'-TERMINAL
PHOSPHATE CYCLASE

(Pyrococcus
horikoshii) 		PF01137
(RTC)
PF05189
(RTC_insert) 		3 SER A 295
GLU A 141
GLU A 241
 None
 0.83A 4ymgB-4o89A:
undetectable		 4ymgB-4o89A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4op4 SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Vibrio cholerae) 		PF01546
(Peptidase_M20) 		3 SER A  18
GLU A  12
GLU A 114
 None
 0.83A 4ymgB-4op4A:
undetectable		 4ymgB-4op4A:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pd3 NONMUSCLE MYOSIN
HEAVY CHAIN B,
ALPHA-ACTININ A
CHIMERA PROTEIN

(Homo sapiens;
Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		3 SER A  49
GLU A 780
GLU A 863
 None
 0.87A 4ymgB-4pd3A:
undetectable		 4ymgB-4pd3A:
12.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r04 TOXIN A

(Clostridioides
difficile) 		PF11713
(Peptidase_C80)
PF12918
(TcdB_N)
PF12919
(TcdA_TcdB)
PF12920
(TcdA_TcdB_pore) 		3 SER A 380
GLU A 514
GLU A 711
 None
 0.54A 4ymgB-4r04A:
undetectable		 4ymgB-4r04A:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9g MBP1

(Caldanaerobius
polysaccharolyticus) 		PF13416
(SBP_bac_8) 		3 SER A  35
GLU A 134
GLU A 271
 None
 0.76A 4ymgB-4r9gA:
undetectable		 4ymgB-4r9gA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1

(Homo sapiens;
synthetic
construct) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		3 SER A3892
GLU A3739
GLU A3850
 None
 0.67A 4ymgB-4rh7A:
undetectable		 4ymgB-4rh7A:
5.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1w GLUTAMINE--FRUCTOSE-
6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING]

(Staphylococcus
aureus) 		PF01380
(SIS) 		3 SER A 377
GLU A 394
GLU A 478
 None
 0.70A 4ymgB-4s1wA:
2.5		 4ymgB-4s1wA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xg1 DIAMINOPIMELATE
DECARBOXYLASE

(Psychromonas
ingrahamii) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		3 SER A 378
GLU A  86
GLU A 274
 None
None
LLP  A 508 (-3.8A)
 0.88A 4ymgB-4xg1A:
undetectable		 4ymgB-4xg1A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y05 KINESIN-LIKE PROTEIN
KIF2C

(Homo sapiens) 		PF00225
(Kinesin) 		3 SER A 551
GLU A 436
GLU A 396
 None
 0.81A 4ymgB-4y05A:
undetectable		 4ymgB-4y05A:
20.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ymg PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE

(Podospora
anserina) 		PF01596
(Methyltransf_3) 		3 SER A  49
GLU A  98
GLU A 128
 SAM  A1001 (-2.4A)
SAM  A1001 (-2.7A)
SAM  A1001 (-3.3A)
 0.58A 4ymgB-4ymgA:
39.9		 4ymgB-4ymgA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ymw ABC-TYPE POLAR AMINO
ACID TRANSPORT
SYSTEM, ATPASE
COMPONENT

(Caldanaerobacter
subterraneus) 		no annotation 3 SER J  38
GLU J 217
GLU J  28
 None
 0.68A 4ymgB-4ymwJ:
undetectable		 4ymgB-4ymwJ:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zkt BONTOXILYSIN A
BOTULINUM NEUROTOXIN
TYPE E,
NONTOXIC-NONHEMAGGLU
TININ COMPONENT,
NTNH

(Clostridium
botulinum;
Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N)
PF01742
(Peptidase_M27)
PF07953
(Toxin_R_bind_N)
PF08470
(NTNH_C) 		3 SER B 927
GLU B1030
GLU A 465
 None
 0.72A 4ymgB-4zktB:
undetectable		 4ymgB-4zktB:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8j VWA2

(Sulfolobus
acidocaldarius) 		PF00092
(VWA) 		3 SER A 146
GLU A 225
GLU A 220
 SO4  A1367 (-3.4A)
GOL  A1369 (-3.0A)
None
 0.73A 4ymgB-5a8jA:
undetectable		 4ymgB-5a8jA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7o PROLIFERATING CELL
NUCLEAR ANTIGEN

(Leishmania
donovani) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		3 SER A  96
GLU A   3
GLU A 104
 None
 0.84A 4ymgB-5b7oA:
undetectable		 4ymgB-5b7oA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ck7 ADP-DEPENDENT
GLUCOKINASE

(Mus musculus) 		PF04587
(ADP_PFK_GK) 		3 SER A 490
GLU A 297
GLU A 325
 None
 0.80A 4ymgB-5ck7A:
4.7		 4ymgB-5ck7A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqi SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 1

(Homo sapiens) 		PF00083
(Sugar_tr) 		3 SER A 368
GLU A 426
GLU A  41
 None
 0.81A 4ymgB-5eqiA:
undetectable		 4ymgB-5eqiA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1y MCCC FAMILY PROTEIN

(Bacillus cereus) 		PF02016
(Peptidase_S66) 		3 SER A  93
GLU A 246
GLU A 315
 None
 0.85A 4ymgB-5f1yA:
undetectable		 4ymgB-5f1yA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 SER B  62
GLU B  54
GLU B 178
 None
 0.74A 4ymgB-5fq6B:
undetectable		 4ymgB-5fq6B:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 2
TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 6
TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 8

(Homo sapiens;
Homo sapiens;
Homo sapiens) 		no annotation
PF07571
(TAF6_C)
PF10406
(TAF8_C) 		3 SER I 853
GLU L 177
GLU J 226
 None
 0.76A 4ymgB-5furI:
undetectable		 4ymgB-5furI:
11.55