SIMILAR PATTERNS OF AMINO ACIDS FOR 4YIA_B_IMNB401_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cid T CELL SURFACE
GLYCOPROTEIN CD4

(Rattus
norvegicus) 		PF05790
(C2-set)
PF09191
(CD4-extracel) 		5 LEU A  66
LEU A  72
SER A  25
LEU A  48
LEU A  89
 None
 1.05A 4yiaA-1cidA:
0.0		 4yiaA-1cidA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ekq HYDROXYETHYLTHIAZOLE
KINASE

(Bacillus
subtilis) 		PF02110
(HK) 		5 SER A  17
LEU A 199
SER A  42
LEU A  36
LEU A 249
 None
 1.19A 4yiaA-1ekqA:
0.0		 4yiaA-1ekqA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i8q HYALURONATE LYASE

(Streptococcus
agalactiae) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		5 LEU A 351
LEU A 354
SER A 313
LEU A 316
LEU A 303
 None
 1.22A 4yiaA-1i8qA:
0.0		 4yiaA-1i8qA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfi PHOSPHOGLUCOMUTASE 1

(Paramecium
tetraurelia) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 SER A 354
LEU A 344
LEU A 389
SER A 326
LEU A 329
 None
 1.02A 4yiaA-1kfiA:
0.5		 4yiaA-1kfiA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgu ACTIN INTERACTING
PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		6 LEU A 591
LEU A 345
SER A 388
LEU A 378
ASN A 380
LEU A 350
 None
 1.36A 4yiaA-1pguA:
0.0		 4yiaA-1pguA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q2l PROTEASE III

(Escherichia
coli) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF16187
(Peptidase_M16_M) 		5 SER A 260
LEU A  86
LEU A  90
SER A 227
LEU A 154
 None
 1.08A 4yiaA-1q2lA:
0.0		 4yiaA-1q2lA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sny SNIFFER CG10964-PA

(Drosophila
melanogaster) 		PF00106
(adh_short) 		5 SER A 153
GLN A 222
SER A 197
LEU A 198
ASN A 240
 None
 0.85A 4yiaA-1snyA:
0.0		 4yiaA-1snyA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0n PLATELET
GLYCOPROTEIN IB

(Homo sapiens) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		5 SER D  39
LEU D  76
LEU D  48
LEU D  62
LEU D  95
 None
 1.21A 4yiaA-1u0nD:
undetectable		 4yiaA-1u0nD:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xly SHE2P

(Saccharomyces
cerevisiae) 		PF11435
(She2p) 		5 GLN A 122
LEU A 121
LEU A 117
LEU A  35
LEU A 136
 None
 1.08A 4yiaA-1xlyA:
0.3		 4yiaA-1xlyA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zuo HYPOTHETICAL PROTEIN
LOC92912

(Homo sapiens) 		PF00179
(UQ_con) 		5 SER A 228
LEU A 303
LEU A 330
LEU A 243
LEU A 292
 None
 0.96A 4yiaA-1zuoA:
undetectable		 4yiaA-1zuoA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bnh RIBONUCLEASE
INHIBITOR

(Sus scrofa) 		PF13516
(LRR_6) 		5 LEU A 398
LEU A 413
SER A 380
ASN A 403
LEU A 429
 None
 1.18A 4yiaA-2bnhA:
undetectable		 4yiaA-2bnhA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bv8 C-PHYCOCYANIN ALPHA
SUBUNIT

(Gracilaria
chilensis) 		PF00502
(Phycobilisome) 		5 LEU A  51
LEU A  44
SER A 143
LEU A 142
LEU A 154
 None
 0.94A 4yiaA-2bv8A:
undetectable		 4yiaA-2bv8A:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d04 NEOCULIN ACIDIC
SUBUNIT

(Molineria
latifolia) 		PF01453
(B_lectin) 		5 SER A  18
LEU A  31
LEU A  54
SER A   2
LEU A  16
 None
 1.18A 4yiaA-2d04A:
undetectable		 4yiaA-2d04A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dtc RAL GUANINE
NUCLEOTIDE EXCHANGE
FACTOR RALGPS1A

(Mus musculus) 		PF00169
(PH) 		5 LEU A  81
LEU A 107
SER A  32
LEU A  31
LEU A   7
 None
 1.05A 4yiaA-2dtcA:
undetectable		 4yiaA-2dtcA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dzd PYRUVATE CARBOXYLASE

(Geobacillus
thermodenitrificans) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 SER A 327
GLN A 217
LEU A 229
SER A 324
LEU A 325
 None
 1.22A 4yiaA-2dzdA:
undetectable		 4yiaA-2dzdA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eg3 PROBABLE THIOSULFATE
SULFURTRANSFERASE

(Thermus
thermophilus) 		PF00581
(Rhodanese) 		5 LEU A  60
LEU A  82
SER A  32
LEU A  31
LEU A  66
 None
 1.07A 4yiaA-2eg3A:
undetectable		 4yiaA-2eg3A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fgt TWO-COMPONENT SYSTEM
YYCF/YYCG REGULATORY
PROTEIN YYCH

(Bacillus
subtilis) 		PF07435
(YycH) 		5 SER A 188
LEU A 126
LEU A 128
LEU A  92
TRP A  89
 None
 0.79A 4yiaA-2fgtA:
undetectable		 4yiaA-2fgtA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i4c BICARBONATE
TRANSPORTER

(Synechocystis
sp. PCC 6803) 		PF13379
(NMT1_2) 		5 SER A 423
LEU A 389
SER A 367
LEU A 370
LEU A 444
 None
 1.04A 4yiaA-2i4cA:
undetectable		 4yiaA-2i4cA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j1d DISHEVELED-ASSOCIATE
D ACTIVATOR OF
MORPHOGENESIS 1

(Homo sapiens) 		PF02181
(FH2) 		5 LEU G 874
LEU G 813
SER G 838
LEU G 840
LEU G 860
 None
 1.07A 4yiaA-2j1dG:
undetectable		 4yiaA-2j1dG:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mpl ZINC FINGER PROTEIN
ZFPM1

(Mus musculus) 		no annotation 5 SER A 196
LEU A 166
SER A 123
LEU A 124
ASN A 176
 None
 1.20A 4yiaA-2mplA:
undetectable		 4yiaA-2mplA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mvu ACTINORHODIN
POLYKETIDE SYNTHASE
ACYL CARRIER PROTEIN

(Streptomyces
coelicolor) 		PF00550
(PP-binding) 		5 LEU A  77
LEU A  74
SER A  42
LEU A  45
LEU A  52
 None
None
SDO  A 101 (-1.5A)
None
None
 1.18A 4yiaA-2mvuA:
undetectable		 4yiaA-2mvuA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p65 HYPOTHETICAL PROTEIN
PF08_0063

(Plasmodium
falciparum) 		PF00004
(AAA) 		5 SER A  88
LEU A 107
LEU A 144
SER A  87
LEU A  86
 None
 1.00A 4yiaA-2p65A:
undetectable		 4yiaA-2p65A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pce PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Roseovarius
nubinhibens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 SER A  50
LEU A 121
LEU A 313
SER A 273
LEU A 282
 None
 1.12A 4yiaA-2pceA:
undetectable		 4yiaA-2pceA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pqd 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Agrobacterium
sp.) 		PF00275
(EPSP_synthase) 		5 LEU A 228
LEU A 207
SER A  42
LEU A 234
LEU A 182
 None
 1.14A 4yiaA-2pqdA:
undetectable		 4yiaA-2pqdA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pqd 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Agrobacterium
sp.) 		PF00275
(EPSP_synthase) 		5 SER A 261
LEU A 277
LEU A 281
SER A 308
LEU A 256
 None
 1.20A 4yiaA-2pqdA:
undetectable		 4yiaA-2pqdA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ra8 UNCHARACTERIZED
PROTEIN Q64V53_BACFR

(Bacteroides
fragilis) 		PF05406
(WGR) 		5 SER A 197
GLN A 161
LEU A 185
LEU A 164
LEU A 177
 None
 1.10A 4yiaA-2ra8A:
undetectable		 4yiaA-2ra8A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 SER A 310
GLN A 277
LEU A 293
LEU A 279
ASN A 303
 None
None
None
None
ADP  A1490 (-3.2A)
 1.13A 4yiaA-2vosA:
undetectable		 4yiaA-2vosA:
21.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xn6 THYROXINE-BINDING
GLOBULIN

(Homo sapiens) 		PF00079
(Serpin) 		6 GLN A 238
LEU A 246
LEU A 248
SER A 265
LEU A 269
LEU A 276
 T44  A1370 (-3.3A)
T44  A1370 (-4.6A)
None
None
T44  A1370 (-4.0A)
None
 1.22A 4yiaA-2xn6A:
54.1		 4yiaA-2xn6A:
99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xn6 THYROXINE-BINDING
GLOBULIN

(Homo sapiens) 		PF00079
(Serpin) 		7 SER A  23
GLN A 238
LEU A 246
LEU A 248
LEU A 269
ASN A 273
LEU A 276
 T44  A1370 (-4.3A)
T44  A1370 (-3.3A)
T44  A1370 (-4.6A)
None
T44  A1370 (-4.0A)
T44  A1370 ( 3.3A)
None
 1.12A 4yiaA-2xn6A:
54.1		 4yiaA-2xn6A:
99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xn6 THYROXINE-BINDING
GLOBULIN

(Homo sapiens) 		PF00079
(Serpin) 		8 SER A  23
SER A  24
GLN A 238
SER A 266
LEU A 269
TRP A 272
ASN A 273
LEU A 276
 T44  A1370 (-4.3A)
T44  A1370 ( 4.7A)
T44  A1370 (-3.3A)
T44  A1370 ( 4.1A)
T44  A1370 (-4.0A)
None
T44  A1370 ( 3.3A)
None
 0.91A 4yiaA-2xn6A:
54.1		 4yiaA-2xn6A:
99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xn6 THYROXINE-BINDING
GLOBULIN

(Homo sapiens) 		PF00079
(Serpin) 		8 SER A  24
GLN A 238
LEU A 246
LEU A 248
LEU A 269
TRP A 272
ASN A 273
LEU A 276
 T44  A1370 ( 4.7A)
T44  A1370 (-3.3A)
T44  A1370 (-4.6A)
None
T44  A1370 (-4.0A)
None
T44  A1370 ( 3.3A)
None
 0.49A 4yiaA-2xn6A:
54.1		 4yiaA-2xn6A:
99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xn6 THYROXINE-BINDING
GLOBULIN

(Homo sapiens) 		PF00079
(Serpin) 		8 SER A  24
GLN A 238
LEU A 248
SER A 266
LEU A 269
TRP A 272
ASN A 273
LEU A 276
 T44  A1370 ( 4.7A)
T44  A1370 (-3.3A)
None
T44  A1370 ( 4.1A)
T44  A1370 (-4.0A)
None
T44  A1370 ( 3.3A)
None
 0.78A 4yiaA-2xn6A:
54.1		 4yiaA-2xn6A:
99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xn6 THYROXINE-BINDING
GLOBULIN

(Homo sapiens) 		PF00079
(Serpin) 		5 SER A  24
LEU A 269
TRP A 272
ASN A 273
LEU A 276
 T44  A1370 ( 4.7A)
T44  A1370 (-4.0A)
None
T44  A1370 ( 3.3A)
None
 1.18A 4yiaA-2xn6A:
54.1		 4yiaA-2xn6A:
99.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ymu WD-40 REPEAT PROTEIN

(Nostoc
punctiforme) 		PF00400
(WD40) 		5 SER A  25
GLN A 297
LEU A 288
LEU A 299
ASN A  44
 None
 1.17A 4yiaA-2ymuA:
undetectable		 4yiaA-2ymuA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Mus musculus) 		PF11921
(DUF3439)
PF13306
(LRR_5)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 SER A  60
LEU A  72
SER A 108
LEU A 107
LEU A 123
 None
 1.21A 4yiaA-2z81A:
undetectable		 4yiaA-2z81A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a8p T-LYMPHOMA INVASION
AND
METASTASIS-INDUCING
PROTEIN 2

(Mus musculus) 		PF00169
(PH) 		5 LEU A 540
LEU A 545
SER A 589
LEU A 588
LEU A 511
 None
 1.20A 4yiaA-3a8pA:
undetectable		 4yiaA-3a8pA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2d CD180 ANTIGEN

(Homo sapiens) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 LEU A 474
LEU A 492
SER A 460
ASN A 479
LEU A 503
 None
 1.02A 4yiaA-3b2dA:
undetectable		 4yiaA-3b2dA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ciy TOLL-LIKE RECEPTOR 3

(Mus musculus) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 SER A  88
LEU A 104
LEU A  80
LEU A  66
LEU A  98
 A  D  45 ( 4.3A)
None
None
None
None
 1.18A 4yiaA-3ciyA:
undetectable		 4yiaA-3ciyA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ciy TOLL-LIKE RECEPTOR 3

(Mus musculus) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 SER A 213
LEU A 226
LEU A 204
LEU A 186
LEU A 176
 None
 1.20A 4yiaA-3ciyA:
undetectable		 4yiaA-3ciyA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dad FH1/FH2
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		no annotation 5 GLN A  91
LEU A  82
LEU A  51
SER A  44
LEU A  45
 None
 1.19A 4yiaA-3dadA:
undetectable		 4yiaA-3dadA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f95 BETA-GLUCOSIDASE

(Pseudoalteromonas
sp. BB1) 		no annotation 5 LEU A 782
LEU A 732
SER A 790
LEU A 791
LEU A 762
 None
 1.17A 4yiaA-3f95A:
undetectable		 4yiaA-3f95A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g2p PCZA361.24

(Amycolatopsis
orientalis) 		PF13649
(Methyltransf_25) 		5 LEU A 171
LEU A 169
SER A 124
LEU A 153
LEU A 242
 None
None
SAH  A 500 ( 4.7A)
None
None
 1.18A 4yiaA-3g2pA:
undetectable		 4yiaA-3g2pA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gc6 ECTO-NAD+
GLYCOHYDROLASE (CD38
MOLECULE)

(Bos taurus) 		PF02267
(Rib_hydrolayse) 		5 SER A 248
SER A 243
LEU A 232
ASN A 201
LEU A 124
 None
None
None
NAG  A 501 (-1.9A)
NAG  A 501 ( 4.6A)
 1.08A 4yiaA-3gc6A:
undetectable		 4yiaA-3gc6A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3goz LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN

(Legionella
pneumophila) 		no annotation 5 SER A 229
LEU A 191
SER A 200
LEU A 201
LEU A 179
 None
 1.04A 4yiaA-3gozA:
undetectable		 4yiaA-3gozA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h77 PQS BIOSYNTHETIC
ENZYME

(Pseudomonas
aeruginosa) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 SER A  82
LEU A 193
LEU A 155
SER A 143
ASN A 287
 None
CSJ  A 112 (-4.5A)
None
None
CSJ  A 112 ( 3.8A)
 1.21A 4yiaA-3h77A:
undetectable		 4yiaA-3h77A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT

(Saccharomyces
cerevisiae) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		5 SER A 243
LEU A 160
LEU A 227
SER A 237
LEU A 236
 None
 1.15A 4yiaA-3iayA:
undetectable		 4yiaA-3iayA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jx9 PUTATIVE
PHOSPHOHEPTOSE
ISOMERASE

(Exiguobacterium
sibiricum) 		PF10740
(DUF2529) 		5 GLN A  19
LEU A  16
SER A 146
LEU A 149
LEU A 125
 None
 1.13A 4yiaA-3jx9A:
undetectable		 4yiaA-3jx9A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9y 1,25-DIHYDROXYVITAMI
N D(3)
24-HYDROXYLASE,
MITOCHONDRIAL

(Rattus
norvegicus) 		PF00067
(p450) 		5 SER A 106
LEU A 115
LEU A 109
ASN A 418
LEU A 422
 None
 1.22A 4yiaA-3k9yA:
undetectable		 4yiaA-3k9yA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o6n APL1

(Anopheles
gambiae) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 SER A 389
GLN A 449
LEU A 422
SER A 413
LEU A 453
 None
 1.10A 4yiaA-3o6nA:
undetectable		 4yiaA-3o6nA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oja ANOPHELES
PLASMODIUM-RESPONSIV
E LEUCINE-RICH
REPEAT PROTEIN 1

(Anopheles
gambiae) 		PF13855
(LRR_8) 		5 SER B 389
GLN B 449
LEU B 422
SER B 413
LEU B 453
 None
 1.10A 4yiaA-3ojaB:
undetectable		 4yiaA-3ojaB:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qcw NEUREXIN-1-ALPHA

(Bos taurus) 		PF00008
(EGF)
PF02210
(Laminin_G_2) 		5 LEU A 774
LEU A 776
SER A 878
LEU A 751
LEU A 830
 None
 1.19A 4yiaA-3qcwA:
undetectable		 4yiaA-3qcwA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rh7 HYPOTHETICAL
OXIDOREDUCTASE

(Sinorhizobium
meliloti) 		PF01613
(Flavin_Reduct) 		5 SER A 270
SER A 269
SER A 195
LEU A 196
LEU A 210
 None
 1.00A 4yiaA-3rh7A:
undetectable		 4yiaA-3rh7A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rsi PUTATIVE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus) 		PF00378
(ECH_1) 		5 GLN A 118
LEU A 150
LEU A 179
LEU A 169
LEU A 117
 None
 1.19A 4yiaA-3rsiA:
undetectable		 4yiaA-3rsiA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s1s RESTRICTION
ENDONUCLEASE BPUSI

(Bacillus
pumilus) 		PF02384
(N6_Mtase)
PF15516
(BpuSI_N) 		5 LEU A 621
LEU A 668
SER A 682
LEU A 685
LEU A 634
 None
 1.16A 4yiaA-3s1sA:
undetectable		 4yiaA-3s1sA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsr RIBONUCLEASE
INHIBITOR

(Mus musculus) 		PF13516
(LRR_6) 		5 LEU E 398
LEU E 413
SER E 380
ASN E 403
LEU E 429
 None
 1.13A 4yiaA-3tsrE:
undetectable		 4yiaA-3tsrE:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umc HALOACID
DEHALOGENASE

(Pseudomonas
aeruginosa) 		PF13419
(HAD_2) 		5 SER A  18
SER A  17
LEU A 137
LEU A  12
LEU A 222
 None
 1.16A 4yiaA-3umcA:
undetectable		 4yiaA-3umcA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aio LIMIT DEXTRINASE

(Hordeum vulgare) 		PF02922
(CBM_48)
PF11852
(DUF3372) 		5 LEU A  57
LEU A  31
SER A  91
LEU A  92
LEU A 114
 None
 1.15A 4yiaA-4aioA:
undetectable		 4yiaA-4aioA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyu DNA PROTECTION
DURING STARVATION
PROTEIN

(Yersinia pestis) 		PF00210
(Ferritin) 		5 LEU A 104
LEU A  43
SER A 152
LEU A 155
LEU A 121
 None
 1.17A 4yiaA-4dyuA:
undetectable		 4yiaA-4dyuA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewg BETA-KETOACYL
SYNTHASE

(Paraburkholderia
phymatum) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 SER A 162
SER A 161
LEU A 402
SER A 107
LEU A 238
 None
 1.21A 4yiaA-4ewgA:
undetectable		 4yiaA-4ewgA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f9d POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE

(Escherichia
coli) 		PF01522
(Polysacc_deac_1)
PF14883
(GHL13) 		5 LEU A 608
SER A 624
LEU A 627
TRP A 630
LEU A 634
 None
 1.00A 4yiaA-4f9dA:
undetectable		 4yiaA-4f9dA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fcg UNCHARACTERIZED
PROTEIN

(Xanthomonas
euvesicatoria) 		PF13855
(LRR_8) 		6 SER A 341
LEU A 356
LEU A 333
SER A 319
LEU A 320
LEU A 350
 None
 1.44A 4yiaA-4fcgA:
undetectable		 4yiaA-4fcgA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdu PUTATIVE MULTIPLE
INOSITOL
POLYPHOSPHATE
HISTIDINE
PHOSPHATASE 1

(Bacteroides
thetaiotaomicron) 		PF00328
(His_Phos_2) 		5 SER A 112
LEU A  70
LEU A 100
SER A 251
LEU A 256
 None
 1.10A 4yiaA-4fduA:
undetectable		 4yiaA-4fduA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g2c DYP2

(Amycolatopsis
sp. ATCC 39116) 		no annotation 5 LEU A  11
LEU A  32
SER A 459
LEU A  27
LEU A  71
 None
 1.09A 4yiaA-4g2cA:
undetectable		 4yiaA-4g2cA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jmp C-TERMINAL FRAGMENT
OF CAPA, PROTEIN
TYROSINE KINASE

(Staphylococcus
aureus) 		PF01656
(CbiA) 		5 SER A1113
LEU A1143
LEU A1074
ASN A1150
LEU A1148
 None
 1.01A 4yiaA-4jmpA:
undetectable		 4yiaA-4jmpA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc5 RHIE PROTEIN

(Paraburkholderia
rhizoxinica) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 SER A3231
SER A3232
LEU A3063
LEU A3414
LEU A3419
 None
 1.09A 4yiaA-4kc5A:
undetectable		 4yiaA-4kc5A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kt1 LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4

(Homo sapiens) 		PF01462
(LRRNT)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 GLN A 342
LEU A 315
LEU A 338
LEU A 350
LEU A 345
 None
 1.22A 4yiaA-4kt1A:
undetectable		 4yiaA-4kt1A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kt1 LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4

(Homo sapiens) 		PF01462
(LRRNT)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 SER A 215
LEU A 206
LEU A 184
SER A 191
LEU A 173
 None
 1.22A 4yiaA-4kt1A:
undetectable		 4yiaA-4kt1A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ly7 RIBONUCLEASE H

(unidentified) 		PF00075
(RNase_H) 		5 LEU A  59
LEU A  56
SER A  68
LEU A  67
TRP A 118
 None
 0.98A 4yiaA-4ly7A:
undetectable		 4yiaA-4ly7A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4my0 GCN5-RELATED
N-ACETYLTRANSFERASE

(Kribbella
flavida) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		5 LEU A 345
LEU A 348
SER A 320
LEU A 319
LEU A 338
 None
 1.00A 4yiaA-4my0A:
undetectable		 4yiaA-4my0A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nkh E3 UBIQUITIN-PROTEIN
LIGASE SSPH1

(Salmonella
enterica) 		no annotation 5 SER A 251
LEU A 238
LEU A 221
LEU A 231
LEU A 214
 None
 1.19A 4yiaA-4nkhA:
undetectable		 4yiaA-4nkhA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nnz PROBABLE ZINC
PROTEASE

(Pseudomonas
aeruginosa) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 SER A 298
LEU A 339
LEU A 336
SER A 314
LEU A 313
 None
 1.19A 4yiaA-4nnzA:
undetectable		 4yiaA-4nnzA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ow2 YOP EFFECTOR YOPM

(Yersinia
enterocolitica) 		PF12468
(TTSSLRR) 		5 LEU A  89
LEU A 106
SER A 102
LEU A 103
LEU A 116
 None
 1.20A 4yiaA-4ow2A:
undetectable		 4yiaA-4ow2A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ow2 YOP EFFECTOR YOPM

(Yersinia
enterocolitica) 		PF12468
(TTSSLRR) 		5 LEU A 149
LEU A 168
SER A 164
LEU A 165
LEU A 178
 None
 1.18A 4yiaA-4ow2A:
undetectable		 4yiaA-4ow2A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qxe LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, LINKER,
VARIABLE LYMPHOCYTE
RECEPTOR B

(Eptatretus
burgeri;
Homo sapiens) 		PF01462
(LRRNT)
PF11921
(DUF3439)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 SER A 215
LEU A 206
LEU A 184
SER A 191
LEU A 173
 None
 1.21A 4yiaA-4qxeA:
undetectable		 4yiaA-4qxeA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qxf LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF01462
(LRRNT)
PF11921
(DUF3439)
PF13855
(LRR_8) 		5 SER A 215
LEU A 206
LEU A 184
SER A 191
LEU A 173
 None
 1.19A 4yiaA-4qxfA:
undetectable		 4yiaA-4qxfA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u09 LIC12759

(Leptospira
interrogans) 		PF13855
(LRR_8) 		5 LEU A 276
LEU A 253
SER A 239
LEU A 240
LEU A 270
 None
 1.11A 4yiaA-4u09A:
undetectable		 4yiaA-4u09A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxm TRANSCRIPTIONAL
REGULATOR FLEQ

(Pseudomonas
aeruginosa) 		PF06490
(FleQ) 		5 LEU A 118
LEU A 114
SER A  17
LEU A  20
LEU A  27
 None
 1.17A 4yiaA-4wxmA:
undetectable		 4yiaA-4wxmA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xri PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		5 SER A 788
LEU A 758
LEU A 710
LEU A 735
LEU A 696
 None
 1.06A 4yiaA-4xriA:
undetectable		 4yiaA-4xriA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0c TOLL-LIKE RECEPTOR
13

(Mus musculus) 		PF00560
(LRR_1)
PF13516
(LRR_6)
PF13855
(LRR_8) 		6 SER A 276
LEU A 342
LEU A 308
SER A 278
LEU A 301
LEU A 334
 NAG  A 907 ( 4.6A)
None
None
NAG  A 907 (-3.5A)
None
None
 1.45A 4yiaA-4z0cA:
undetectable		 4yiaA-4z0cA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0c TOLL-LIKE RECEPTOR
13

(Mus musculus) 		PF00560
(LRR_1)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 SER A 302
LEU A 349
LEU A 343
LEU A 324
LEU A 367
 NAG  A 907 ( 4.5A)
None
None
None
None
 1.16A 4yiaA-4z0cA:
undetectable		 4yiaA-4z0cA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c8p MOCVNH3 VARIANT

(Magnaporthe
oryzae) 		PF01476
(LysM)
PF08881
(CVNH) 		5 SER A  54
LEU A 137
SER A  44
LEU A  43
LEU A  16
 None
 1.18A 4yiaA-5c8pA:
undetectable		 4yiaA-5c8pA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gtm INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1

(Homo sapiens) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
PF02212
(GED) 		5 LEU A 111
LEU A 176
SER A  84
LEU A  87
LEU A 327
 None
 1.01A 4yiaA-5gtmA:
undetectable		 4yiaA-5gtmA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iki CYTOCHROME P450(MEG)

(Bacillus
megaterium) 		PF00067
(p450) 		5 SER A 144
LEU A 369
SER A 249
LEU A 252
LEU A 259
 None
 1.00A 4yiaA-5ikiA:
undetectable		 4yiaA-5ikiA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixq RECEPTOR-LIKE
PROTEIN KINASE 5

(Arabidopsis
thaliana) 		PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 SER A  95
LEU A 134
LEU A 105
LEU A 121
LEU A 151
 None
 1.13A 4yiaA-5ixqA:
undetectable		 4yiaA-5ixqA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kh1 INVASION PLASMID
ANTIGEN

(Shigella
flexneri) 		PF12468
(TTSSLRR)
PF14496
(NEL) 		5 LEU A 177
LEU A 164
SER A 153
LEU A 154
LEU A 161
 None
 1.21A 4yiaA-5kh1A:
undetectable		 4yiaA-5kh1A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lki TCDA1

(Photorhabdus
luminescens) 		PF03538
(VRP1) 		5 SER A1095
LEU A1200
LEU A1198
LEU A1234
LEU A1267
 None
 0.96A 4yiaA-5lkiA:
undetectable		 4yiaA-5lkiA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5loq PUTATIVE
HEME-DEPENDENT
PEROXIDASE LMO2113

(Listeria
monocytogenes) 		PF06778
(Chlor_dismutase) 		5 SER A  41
LEU A  98
LEU A  70
SER A 242
LEU A 245
 None
 0.98A 4yiaA-5loqA:
undetectable		 4yiaA-5loqA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m0j SWI5-DEPENDENT HO
EXPRESSION PROTEIN
2,SWI5-DEPENDENT HO
EXPRESSION PROTEIN 3

(Saccharomyces
cerevisiae) 		no annotation 5 GLN D 122
LEU D 121
LEU D 117
LEU D  35
LEU D 136
 None
 1.05A 4yiaA-5m0jD:
undetectable		 4yiaA-5m0jD:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oei UNCHARACTERIZED
PROTEIN FAMILY
UPF0065:TAT PATHWAY
SIGNAL

(Rhodopseudomonas
palustris) 		no annotation 5 SER A 198
SER A 169
LEU A  57
SER A 173
TRP A 262
 OOG  A 401 (-3.1A)
OOG  A 401 (-3.0A)
None
OOG  A 401 (-4.6A)
None
 1.19A 4yiaA-5oeiA:
undetectable		 4yiaA-5oeiA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohe GLOBIN-COUPLED
HISTIDINE KINASE

(Anaeromyxobacter
sp. Fw109-5) 		no annotation 5 LEU A 146
LEU A 120
SER A  28
LEU A  29
LEU A  76
 LEU  A 146 ( 0.6A)
LEU  A 120 ( 0.6A)
SER  A  28 ( 0.0A)
LEU  A  29 ( 0.5A)
LEU  A  76 ( 0.6A)
 1.19A 4yiaA-5oheA:
undetectable		 4yiaA-5oheA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sva DNA REPAIR HELICASE
RAD3

(Saccharomyces
cerevisiae) 		PF06733
(DEAD_2)
PF06777
(HBB)
PF13307
(Helicase_C_2) 		5 LEU Y 171
LEU Y 181
SER Y 110
LEU Y 114
LEU Y 190
 None
 1.22A 4yiaA-5svaY:
undetectable		 4yiaA-5svaY:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t5w INTERFERON LAMBDA
RECEPTOR 1

(Homo sapiens) 		PF01108
(Tissue_fac) 		5 GLN B 114
LEU B 166
LEU B 119
SER B 177
LEU B 176
 None
 1.16A 4yiaA-5t5wB:
undetectable		 4yiaA-5t5wB:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yv5 ATPASE RIL

(Pyrococcus
furiosus) 		no annotation 5 SER A 239
LEU A 200
LEU A 198
SER A 238
LEU A 225
 None
 1.18A 4yiaA-5yv5A:
undetectable		 4yiaA-5yv5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY

(Thermobifida
fusca) 		no annotation 5 LEU G 213
LEU G 210
SER G  54
LEU G  53
TRP G  49
 None
 1.19A 4yiaA-6c66G:
undetectable		 4yiaA-6c66G:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cjk -

(-) 		no annotation 5 SER B  31
SER B  30
LEU B 102
LEU B   4
SER B  74
 None
None
PCA  B   3 ( 4.5A)
PCA  B   3 ( 3.7A)
None
 1.15A 4yiaA-6cjkB:
undetectable		 4yiaA-6cjkB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eqn TRYPTOPHAN SYNTHASE
BETA CHAIN 2

(Sulfobacillus) 		no annotation 5 SER B 365
LEU B  91
LEU B  87
SER B 385
LEU B 388
 None
 1.07A 4yiaA-6eqnB:
undetectable		 4yiaA-6eqnB:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f1s CGLIIR PROTEIN

(Corynebacterium
glutamicum) 		no annotation 5 SER A 611
SER A 610
LEU A 501
LEU A 591
LEU A 523
 None
 1.06A 4yiaA-6f1sA:
undetectable		 4yiaA-6f1sA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fg8 PROBABLE INACTIVE
RECEPTOR KINASE
AT1G27190

(Arabidopsis
thaliana) 		no annotation 5 SER B 100
LEU B  34
SER B  76
LEU B  77
LEU B  84
 None
 1.16A 4yiaA-6fg8B:
undetectable		 4yiaA-6fg8B:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g3w PROBABLE INACTIVE
RECEPTOR KINASE
AT1G27190

(Arabidopsis
thaliana) 		no annotation 5 SER B 100
LEU B  34
SER B  76
LEU B  77
LEU B  45
 None
 1.22A 4yiaA-6g3wB:
undetectable		 4yiaA-6g3wB:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g3w PROBABLE INACTIVE
RECEPTOR KINASE
AT1G27190

(Arabidopsis
thaliana) 		no annotation 5 SER B 100
LEU B  34
SER B  76
LEU B  77
LEU B  84
 None
 1.08A 4yiaA-6g3wB:
undetectable		 4yiaA-6g3wB:
12.10