SIMILAR PATTERNS OF AMINO ACIDS FOR 4YFB_F_PACF601_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ar1 CYTOCHROME C OXIDASE

(Paracoccus
denitrificans) 		PF00116
(COX2)
PF02790
(COX2_TM) 		5 PHE B 188
PHE B 204
VAL B 163
TRP B 183
VAL B 162
 None
 1.32A 4yfbF-1ar1B:
0.0		 4yfbF-1ar1B:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1edz 5,10-METHYLENETETRAH
YDROFOLATE
DEHYDROGENASE

(Saccharomyces
cerevisiae) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		5 SER A 246
PHE A 260
PHE A 280
ILE A 183
VAL A 248
 None
 1.38A 4yfbF-1edzA:
undetectable		 4yfbF-1edzA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s16 TOPOISOMERASE IV
SUBUNIT B

(Escherichia
coli) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		5 SER A1123
PRO A1169
PHE A1179
HIS A1166
VAL A1126
 None
 1.27A 4yfbF-1s16A:
0.0		 4yfbF-1s16A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xo3 RIKEN CDNA
2900073H19

(Mus musculus) 		PF09138
(Urm1) 		5 ILE A  45
HIS A  25
VAL A   7
TRP A  44
VAL A  27
 None
 1.28A 4yfbF-1xo3A:
0.0		 4yfbF-1xo3A:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zso HYPOTHETICAL PROTEIN

(Plasmodium
falciparum) 		PF05907
(DUF866) 		5 TRP A  26
PHE A  44
ILE A  74
VAL A   6
VAL A 155
 None
 1.21A 4yfbF-1zsoA:
0.0		 4yfbF-1zsoA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cyc TYROSYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00579
(tRNA-synt_1b) 		5 PRO A 218
PHE A 177
ILE A 176
HIS A 194
VAL A 195
 None
 1.48A 4yfbF-2cycA:
undetectable		 4yfbF-2cycA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fea 2-HYDROXY-3-KETO-5-M
ETHYLTHIOPENTENYL-1-
PHOSPHATE
PHOSPHATASE

(Bacillus
subtilis) 		PF12710
(HAD) 		5 PHE A  84
PHE A  87
ILE A   8
VAL A 217
VAL A 220
 None
 1.45A 4yfbF-2feaA:
undetectable		 4yfbF-2feaA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m3t BETA-CRYSTALLIN S

(Homo sapiens) 		PF00030
(Crystall) 		5 TRP A 137
PHE A 139
PHE A 173
ILE A 127
VAL A 132
 None
 1.28A 4yfbF-2m3tA:
0.0		 4yfbF-2m3tA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbc FK506-BINDING
PROTEIN 2

(Homo sapiens) 		PF00254
(FKBP_C) 		5 SER A  69
PRO A  75
PHE A  78
TRP A  89
VAL A 131
 None
None
None
PEG  A 201 (-3.7A)
None
 1.44A 4yfbF-2pbcA:
undetectable		 4yfbF-2pbcA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wp1 BROMODOMAIN
TESTIS-SPECIFIC
PROTEIN

(Mus musculus) 		PF00439
(Bromodomain) 		5 PRO A 379
PHE A 372
ILE A 375
HIS A 274
VAL A 268
 None
 1.37A 4yfbF-2wp1A:
0.0		 4yfbF-2wp1A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xi8 PUTATIVE
TRANSCRIPTION
REGULATOR

(Enterococcus
faecalis) 		PF01381
(HTH_3) 		5 SER A  42
PRO A  41
PHE A  61
ILE A  34
VAL A  26
 GOL  A1067 (-2.6A)
None
None
None
None
 1.24A 4yfbF-2xi8A:
undetectable		 4yfbF-2xi8A:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y32 BLR5658 PROTEIN

(Bradyrhizobium
japonicum) 		PF01382
(Avidin) 		5 TRP A  75
PHE A 109
ILE A  60
VAL A  64
VAL A  47
 None
 1.25A 4yfbF-2y32A:
undetectable		 4yfbF-2y32A:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yx0 RADICAL SAM ENZYME

(Pyrococcus
horikoshii) 		PF04055
(Radical_SAM)
PF08608
(Wyosine_form) 		5 PRO A 142
PHE A 171
PHE A 166
ILE A 115
VAL A  42
 None
 1.24A 4yfbF-2yx0A:
undetectable		 4yfbF-2yx0A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcr PUTATIVE
AMINOTRANSFERASE

(Ruegeria sp.
TM1040) 		PF00202
(Aminotran_3) 		5 PRO A 107
PHE A 272
PHE A 265
ILE A 284
VAL A 113
 None
 1.15A 4yfbF-3fcrA:
undetectable		 4yfbF-3fcrA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fv5 DNA TOPOISOMERASE 4
SUBUNIT B

(Escherichia
coli) 		PF02518
(HATPase_c) 		5 SER A 123
PRO A 169
PHE A 179
HIS A 166
VAL A 126
 None
 1.30A 4yfbF-3fv5A:
undetectable		 4yfbF-3fv5A:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gju PUTATIVE
AMINOTRANSFERASE

(Mesorhizobium
japonicum) 		PF00202
(Aminotran_3) 		5 PRO A 108
PHE A 273
PHE A 266
ILE A 285
VAL A 114
 None
 1.17A 4yfbF-3gjuA:
0.0		 4yfbF-3gjuA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jyy LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE

(Enterococcus
faecium) 		no annotation 5 PHE A  55
PHE A  92
ILE A  21
VAL A  64
VAL A  11
 None
 1.20A 4yfbF-3jyyA:
0.1		 4yfbF-3jyyA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2w BETAINE-ALDEHYDE
DEHYDROGENASE

(Pseudoalteromonas
atlantica) 		PF00171
(Aldedh) 		5 SER A  22
PRO A  43
GLN A 183
ILE A  42
VAL A 216
 None
 1.48A 4yfbF-3k2wA:
undetectable		 4yfbF-3k2wA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ktd PREPHENATE
DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF02153
(PDH) 		5 SER A 122
PRO A 124
PHE A 141
ILE A  18
VAL A  72
 None
 1.04A 4yfbF-3ktdA:
undetectable		 4yfbF-3ktdA:
22.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3l91 ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
SUBUNIT BETA

(Pseudomonas
aeruginosa) 		PF01804
(Penicil_amidase) 		9 SER B 217
PRO B 238
PHE B 248
ILE B 274
HIS B 284
VAL B 286
TRP B 378
TRP B 402
VAL B 403
 OCA  B   1 (-2.6A)
OCA  B   1 (-4.0A)
None
None
OCA  B   1 (-4.6A)
OCA  B   1 (-4.0A)
EDO  B 915 ( 3.5A)
OCA  B   1 (-4.6A)
OCA  B   1 (-4.8A)
 0.62A 4yfbF-3l91B:
49.3		 4yfbF-3l91B:
36.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sft CHEMOTAXIS RESPONSE
REGULATOR
PROTEIN-GLUTAMATE
METHYLESTERASE

(Thermotoga
maritima) 		PF01339
(CheB_methylest) 		5 SER A 210
PRO A 178
ILE A 176
VAL A 214
VAL A 228
 None
 1.40A 4yfbF-3sftA:
undetectable		 4yfbF-3sftA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bbo BLR5658 PROTEIN

(Bradyrhizobium
japonicum) 		PF01382
(Avidin) 		5 TRP A  75
PHE A 109
ILE A  60
VAL A  64
VAL A  47
 BTN  A1001 (-4.9A)
None
None
None
None
 1.28A 4yfbF-4bboA:
undetectable		 4yfbF-4bboA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hne PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-ALPHA

(Homo sapiens) 		PF00454
(PI3_PI4_kinase) 		5 PHE A 416
PHE A 405
GLN A 419
ILE A 420
VAL A 199
 PHE  A 416 ( 1.3A)
PHE  A 405 ( 1.3A)
GLN  A 419 ( 0.6A)
ILE  A 420 ( 0.7A)
VAL  A 199 ( 0.6A)
 1.50A 4yfbF-4hneA:
undetectable		 4yfbF-4hneA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4okh CALPAIN-3

(Homo sapiens) 		PF00036
(EF-hand_1)
PF13202
(EF-hand_5)
PF13833
(EF-hand_8) 		5 PHE A 717
PHE A 654
ILE A 661
VAL A 681
VAL A 680
 None
 1.35A 4yfbF-4okhA:
undetectable		 4yfbF-4okhA:
15.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE

(Acidovorax sp.
MR-S7) 		PF01804
(Penicil_amidase) 		12 SER C   1
PRO C  22
TRP C  24
PHE C  32
PHE C  50
GLN C  57
ILE C  58
HIS C  68
VAL C  70
TRP C 165
TRP C 189
VAL C 190
 DKA  C 601 (-2.5A)
None
DKA  C 601 (-4.3A)
None
DKA  C 601 ( 4.5A)
DKA  C 601 (-4.3A)
None
DKA  C 601 (-4.8A)
DKA  C 601 (-4.6A)
DKA  C 601 (-4.8A)
DKA  C 601 (-3.8A)
DKA  C 601 ( 4.8A)
 0.19A 4yfbF-4yfaC:
66.4		 4yfbF-4yfaC:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5c9i PROTEIN RELATED TO
PENICILLIN ACYLASE

(Acidovorax sp.
MR-S7) 		PF01804
(Penicil_amidase) 		12 SER A 203
PRO A 224
TRP A 226
PHE A 234
PHE A 252
GLN A 259
ILE A 260
HIS A 270
VAL A 272
TRP A 367
TRP A 391
VAL A 392
 None
 0.20A 4yfbF-5c9iA:
44.6		 4yfbF-5c9iA:
74.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cbk SHHTL5

(Striga
hermonthica) 		PF12697
(Abhydrolase_6) 		5 SER A 251
PRO A 248
HIS A 246
VAL A 162
VAL A 161
 None
 1.34A 4yfbF-5cbkA:
undetectable		 4yfbF-5cbkA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dm6 50S RIBOSOMAL
PROTEIN L16

(Deinococcus
radiodurans) 		PF00252
(Ribosomal_L16) 		5 PRO J  71
GLN J  47
ILE J  48
VAL J  97
VAL J  98
 None
G  X2485 ( 4.0A)
None
None
None
 1.26A 4yfbF-5dm6J:
undetectable		 4yfbF-5dm6J:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eut PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-ALPHA,ENDOLYSIN,PH
OSPHATIDYLINOSITOL
4-KINASE TYPE
2-ALPHA

(Homo sapiens;
Escherichia
virus T4) 		PF00454
(PI3_PI4_kinase)
PF00959
(Phage_lysozyme) 		5 PHE A 416
PHE A 405
GLN A 419
ILE A 420
VAL A 199
 None
 1.45A 4yfbF-5eutA:
undetectable		 4yfbF-5eutA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i27 MATRIX PROTEIN

(Mouse mammary
tumor virus) 		PF02337
(Gag_p10) 		5 PRO A  48
PHE A  13
ILE A  41
TRP A  58
VAL A  61
 None
 1.20A 4yfbF-5i27A:
undetectable		 4yfbF-5i27A:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6g ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		5 SER A1772
PHE A1641
PHE A1649
ILE A1775
VAL A1780
 None
 1.30A 4yfbF-5i6gA:
undetectable		 4yfbF-5i6gA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6h ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		5 SER A1772
PHE A1641
PHE A1649
ILE A1775
VAL A1780
 None
 1.31A 4yfbF-5i6hA:
undetectable		 4yfbF-5i6hA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6i ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		5 SER A1772
PHE A1641
PHE A1649
ILE A1775
VAL A1780
 None
 1.21A 4yfbF-5i6iA:
undetectable		 4yfbF-5i6iA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kr6 4-AMINOBUTYRATE
TRANSAMINASE

(Pseudomonas) 		PF00202
(Aminotran_3) 		5 PRO A 108
PHE A 272
PHE A 265
ILE A 284
VAL A 114
 None
 1.10A 4yfbF-5kr6A:
0.0		 4yfbF-5kr6A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ks8 PYRUVATE CARBOXYLASE
SUBUNIT ALPHA

(Methylobacillus
flagellatus) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 PHE A 435
ILE A 424
VAL A 398
TRP A 395
VAL A 399
 None
 1.13A 4yfbF-5ks8A:
undetectable		 4yfbF-5ks8A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t0l BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Toxoplasma
gondii) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		5 PHE A 593
ILE A 576
HIS A 534
VAL A 532
VAL A 535
 None
 1.06A 4yfbF-5t0lA:
undetectable		 4yfbF-5t0lA:
22.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ

(Pseudomonas
aeruginosa) 		PF01804
(Penicil_amidase) 		8 PRO A  22
PHE A  32
ILE A  58
HIS A  68
VAL A  70
TRP A 162
TRP A 186
VAL A 187
 83M  A 801 ( 4.9A)
None
None
83M  A 801 ( 4.7A)
83M  A 801 (-4.8A)
83M  A 801 (-4.4A)
None
None
 0.54A 4yfbF-5ubkA:
42.1		 4yfbF-5ubkA:
30.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vni PROTEIN TRANSPORT
PROTEIN SEC23A

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		5 PHE A 570
PHE A 574
VAL A  35
TRP A  21
VAL A  36
 None
 1.36A 4yfbF-5vniA:
undetectable		 4yfbF-5vniA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wya ISOLEUCINE
2-EPIMERASE

(Lactobacillus
buchneri) 		PF00202
(Aminotran_3) 		5 PRO A 411
GLN A 419
ILE A 415
VAL A 398
VAL A 397
 None
 1.45A 4yfbF-5wyaA:
0.0		 4yfbF-5wyaA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ysx -

(-) 		no annotation 5 PRO A 172
PHE A  21
PHE A 107
VAL A 137
VAL A 138
 None
 1.45A 4yfbF-5ysxA:
undetectable		 4yfbF-5ysxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6q EXOSOME RNA HELICASE
MTR4

(Homo sapiens) 		no annotation 5 PHE M 281
PHE M 251
ILE M 296
HIS M 300
VAL M 277
 None
 1.33A 4yfbF-6d6qM:
undetectable		 4yfbF-6d6qM:
undetectable