SIMILAR PATTERNS OF AMINO ACIDS FOR 4YBN_A_ACTA303_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dqw | OROTIDINE5'-PHOSPHATEDECARBOXYLASE (Saccharomycescerevisiae) |
PF00215(OMPdecase) | 3 | VAL A 220TYR A 251ALA A 254 | None | 0.42A | 4ybnA-1dqwA:0.0 | 4ybnA-1dqwA:22.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gqo | DEHYDROQUINASE (Bacillussubtilis) |
PF01220(DHquinase_II) | 3 | VAL A 71TYR A 131ALA A 134 | None | 0.48A | 4ybnA-1gqoA:undetectable | 4ybnA-1gqoA:22.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i2d | ATP SULFURYLASE (Penicilliumchrysogenum) |
PF01583(APS_kinase)PF01747(ATP-sulfurylase)PF14306(PUA_2) | 3 | VAL A 532TYR A 518ALA A 521 | None | 0.47A | 4ybnA-1i2dA:0.0 | 4ybnA-1i2dA:19.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nvm | 4-HYDROXY-2-OXOVALERATE ALDOLASE (Pseudomonas sp.CF600) |
PF00682(HMGL-like)PF07836(DmpG_comm) | 3 | VAL A 32TYR A 72ALA A 75 | None | 0.56A | 4ybnA-1nvmA:0.0 | 4ybnA-1nvmA:24.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pjb | L-ALANINEDEHYDROGENASE (Phormidiumlapideum) |
PF01262(AlaDh_PNT_C)PF05222(AlaDh_PNT_N) | 3 | VAL A 23TYR A 50ALA A 53 | None | 0.51A | 4ybnA-1pjbA:0.0 | 4ybnA-1pjbA:22.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vhz | ADP COMPOUNDSHYDROLASE NUDE (Escherichiacoli) |
PF00293(NUDIX) | 3 | VAL A 127TYR A 89ALA A 92 | None | 0.56A | 4ybnA-1vhzA:0.0 | 4ybnA-1vhzA:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w07 | ACYL-COA OXIDASE (Arabidopsisthaliana) |
PF01756(ACOX)PF02770(Acyl-CoA_dh_M)PF14749(Acyl-CoA_ox_N) | 3 | VAL A 483TYR A 557ALA A 560 | None | 0.47A | 4ybnA-1w07A:0.0 | 4ybnA-1w07A:16.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y79 | PEPTIDYL-DIPEPTIDASEDCP (Escherichiacoli) |
PF01432(Peptidase_M3) | 3 | VAL 1 71TYR 1 27ALA 1 30 | None | 0.41A | 4ybnA-1y791:0.0 | 4ybnA-1y791:16.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d6f | GLUTAMYL-TRNA(GLN)AMIDOTRANSFERASESUBUNIT D (Methanothermobacterthermautotrophicus) |
PF00710(Asparaginase) | 3 | VAL A 397TYR A 182ALA A 185 | None | 0.55A | 4ybnA-2d6fA:0.0 | 4ybnA-2d6fA:22.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dt8 | DEGV FAMILY PROTEIN (Thermusthermophilus) |
PF02645(DegV) | 3 | VAL A 83TYR A 73ALA A 76 | None | 0.51A | 4ybnA-2dt8A:undetectable | 4ybnA-2dt8A:25.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e0p | ENDOGLUCANASE (Ruminiclostridiumthermocellum) |
PF12891(Glyco_hydro_44) | 3 | VAL A 279TYR A 387ALA A 356 | None | 0.56A | 4ybnA-2e0pA:undetectable | 4ybnA-2e0pA:18.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ec5 | DERMONECROTIC TOXIN (Pasteurellamultocida) |
PF11647(MLD) | 3 | VAL A1240TYR A1260ALA A1187 | None | 0.56A | 4ybnA-2ec5A:undetectable | 4ybnA-2ec5A:15.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f2a | GLUTAMYL-TRNA(GLN)AMIDOTRANSFERASESUBUNIT A (Staphylococcusaureus) |
PF01425(Amidase) | 3 | VAL A 220TYR A 466ALA A 469 | None | 0.54A | 4ybnA-2f2aA:undetectable | 4ybnA-2f2aA:21.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f8q | ALKALINETHERMOSTABLEENDOXYLANASE (Bacillus sp.NG-27) |
PF00331(Glyco_hydro_10) | 3 | VAL A 37TYR A 343ALA A 5 | None | 0.57A | 4ybnA-2f8qA:undetectable | 4ybnA-2f8qA:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g18 | PHYCOCYANOBILIN:FERREDOXINOXIDOREDUCTASE (Anabaena sp.) |
PF05996(Fe_bilin_red) | 3 | VAL A 183TYR A 130ALA A 133 | None | 0.55A | 4ybnA-2g18A:undetectable | 4ybnA-2g18A:19.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ho1 | TYPE 4 FIMBRIALBIOGENESIS PROTEINPILF (Pseudomonasaeruginosa) |
PF13414(TPR_11)PF13424(TPR_12) | 3 | VAL A 107TYR A 94ALA A 97 | None | 0.56A | 4ybnA-2ho1A:undetectable | 4ybnA-2ho1A:22.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2n6j | ZINC METALLOPROTEASEZMP1 (Clostridioidesdifficile) |
PF07737(ATLF) | 3 | VAL A 152TYR A 68ALA A 71 | None | 0.47A | 4ybnA-2n6jA:undetectable | 4ybnA-2n6jA:20.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ob5 | HYPOTHETICAL PROTEINATU2016 (Agrobacteriumfabrum) |
PF05025(RbsD_FucU) | 3 | VAL A 38TYR A 118ALA A 121 | None | 0.52A | 4ybnA-2ob5A:undetectable | 4ybnA-2ob5A:21.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p0q | ALR1010 PROTEIN (Nostoc sp. PCC7120) |
PF11535(Calci_bind_CcbP) | 3 | VAL A 4TYR A 118ALA A 121 | None | 0.54A | 4ybnA-2p0qA:undetectable | 4ybnA-2p0qA:20.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pkd | SLAM FAMILY MEMBER 5 (Homo sapiens) |
no annotation | 3 | VAL A 43TYR A 72ALA A 67 | None | 0.54A | 4ybnA-2pkdA:undetectable | 4ybnA-2pkdA:20.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qez | ETHANOLAMINEAMMONIA-LYASE HEAVYCHAIN (Listeriamonocytogenes) |
PF06751(EutB) | 3 | VAL A 323TYR A 312ALA A 315 | None | 0.44A | 4ybnA-2qezA:undetectable | 4ybnA-2qezA:19.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2uyg | 3-DEHYDROQUINATEDEHYDRATASE (Thermusthermophilus) |
PF01220(DHquinase_II) | 3 | VAL A 71TYR A 131ALA A 134 | None | 0.42A | 4ybnA-2uygA:undetectable | 4ybnA-2uygA:23.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vmf | BETA-MANNOSIDASE (Bacteroidesthetaiotaomicron) |
PF00703(Glyco_hydro_2) | 3 | VAL A 416TYR A 406ALA A 409 | None | 0.55A | 4ybnA-2vmfA:undetectable | 4ybnA-2vmfA:14.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wd5 | STRUCTURALMAINTENANCE OFCHROMOSOMES PROTEIN1A (Mus musculus) |
PF06470(SMC_hinge) | 3 | VAL A 618TYR A 530ALA A 533 | None | 0.47A | 4ybnA-2wd5A:undetectable | 4ybnA-2wd5A:22.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y7i | STM4351 (Salmonellaenterica) |
PF00497(SBP_bac_3) | 3 | VAL A 174TYR A 159ALA A 162 | None | 0.57A | 4ybnA-2y7iA:undetectable | 4ybnA-2y7iA:24.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a0h | PHOTOSYSTEM II CP43PROTEIN (Thermosynechococcusvulcanus) |
PF00421(PSII) | 3 | VAL C 99TYR C 186ALA C 93 | None | 0.56A | 4ybnA-3a0hC:undetectable | 4ybnA-3a0hC:17.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3abi | PUTATIVEUNCHARACTERIZEDPROTEIN PH1688 (Pyrococcushorikoshii) |
PF03435(Sacchrp_dh_NADP)PF16653(Sacchrp_dh_C) | 3 | VAL A 193TYR A 142ALA A 202 | None | 0.57A | 4ybnA-3abiA:undetectable | 4ybnA-3abiA:20.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3any | ETHANOLAMINEAMMONIA-LYASE HEAVYCHAIN (Escherichiacoli) |
PF06751(EutB) | 3 | VAL A 323TYR A 312ALA A 315 | None | 0.52A | 4ybnA-3anyA:undetectable | 4ybnA-3anyA:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bdl | STAPHYLOCOCCALNUCLEASEDOMAIN-CONTAININGPROTEIN 1 (Homo sapiens) |
PF00565(SNase)PF00567(TUDOR) | 3 | VAL A 831TYR A 853ALA A 856 | None | 0.54A | 4ybnA-3bdlA:undetectable | 4ybnA-3bdlA:18.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bs4 | UNCHARACTERIZEDPROTEIN PH0321 (Pyrococcushorikoshii) |
no annotation | 3 | VAL A 86TYR A 118ALA A 121 | None | 0.43A | 4ybnA-3bs4A:undetectable | 4ybnA-3bs4A:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cc1 | PUTATIVEALPHA-N-ACETYLGALACTOSAMINIDASE (Bacillushalodurans) |
PF16499(Melibiase_2) | 3 | VAL A 122TYR A 152ALA A 139 | None | 0.55A | 4ybnA-3cc1A:undetectable | 4ybnA-3cc1A:19.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g10 | CCR4-NOT COMPLEXSUBUNIT CAF1 (Schizosaccharomycespombe) |
PF04857(CAF1) | 3 | VAL A 79TYR A 170ALA A 173 | None | 0.39A | 4ybnA-3g10A:undetectable | 4ybnA-3g10A:22.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gmi | UPF0348 PROTEINMJ0951 (Methanocaldococcusjannaschii) |
PF05636(HIGH_NTase1)PF16581(HIGH_NTase1_ass) | 3 | VAL A 170TYR A 193ALA A 196 | None | 0.57A | 4ybnA-3gmiA:undetectable | 4ybnA-3gmiA:17.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i27 | HEMAGGLUTININ-ESTERASE (Bovinetorovirus) |
PF02710(Hema_HEFG)PF03996(Hema_esterase) | 3 | VAL A 283TYR A 128ALA A 131 | None | 0.56A | 4ybnA-3i27A:undetectable | 4ybnA-3i27A:20.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iwj | PUTATIVEAMINOALDEHYDEDEHYDROGENASE (Pisum sativum) |
PF00171(Aldedh) | 3 | VAL A 204TYR A 77ALA A 80 | None | 0.55A | 4ybnA-3iwjA:undetectable | 4ybnA-3iwjA:17.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iwk | AMINOALDEHYDEDEHYDROGENASE (Pisum sativum) |
PF00171(Aldedh) | 3 | VAL A 204TYR A 77ALA A 80 | None | 0.49A | 4ybnA-3iwkA:undetectable | 4ybnA-3iwkA:18.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kb6 | D-LACTATEDEHYDROGENASE (Aquifexaeolicus) |
PF00389(2-Hacid_dh)PF02826(2-Hacid_dh_C) | 3 | VAL A 311TYR A 16ALA A 19 | None | 0.54A | 4ybnA-3kb6A:undetectable | 4ybnA-3kb6A:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lk6 | LIPOPROTEIN YBBD (Bacillussubtilis) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C) | 3 | VAL A 81TYR A 109ALA A 112 | None | 0.52A | 4ybnA-3lk6A:undetectable | 4ybnA-3lk6A:18.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lm2 | PUTATIVE KINASE (Agrobacteriumfabrum) |
PF00480(ROK) | 3 | VAL A 42TYR A 86ALA A 89 | None | 0.35A | 4ybnA-3lm2A:undetectable | 4ybnA-3lm2A:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n0c | THYMIDYLATE SYNTHASETHYX (Thermotogamaritima) |
PF02511(Thy1) | 3 | VAL A 11TYR A 186ALA A 189 | None | 0.53A | 4ybnA-3n0cA:undetectable | 4ybnA-3n0cA:21.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n2b | DIAMINOPIMELATEDECARBOXYLASE (Vibrio cholerae) |
PF00278(Orn_DAP_Arg_deC)PF02784(Orn_Arg_deC_N) | 3 | VAL A 194TYR A 183ALA A 186 | None | 0.55A | 4ybnA-3n2bA:undetectable | 4ybnA-3n2bA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qok | PUTATIVE CHITINASEII (Klebsiellapneumoniae) |
PF00704(Glyco_hydro_18) | 3 | VAL A 207TYR A 259ALA A 262 | None | 0.53A | 4ybnA-3qokA:undetectable | 4ybnA-3qokA:22.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r1x | 2-OXO-3-DEOXYGALACTONATE KINASE (Klebsiellapneumoniae) |
PF05035(DGOK) | 3 | VAL A 234TYR A 259ALA A 262 | None | 0.52A | 4ybnA-3r1xA:undetectable | 4ybnA-3r1xA:22.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r64 | NAD DEPENDENTBENZALDEHYDEDEHYDROGENASE (Corynebacteriumglutamicum) |
PF00171(Aldedh) | 3 | VAL A 151TYR A 56ALA A 59 | VAL A 151 ( 0.6A)TYR A 56 ( 1.3A)ALA A 59 ( 0.0A) | 0.29A | 4ybnA-3r64A:undetectable | 4ybnA-3r64A:20.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u80 | 3-DEHYDROQUINATEDEHYDRATASE, TYPE II (Bifidobacteriumlongum) |
PF01220(DHquinase_II) | 3 | VAL A 72TYR A 135ALA A 138 | None | 0.34A | 4ybnA-3u80A:undetectable | 4ybnA-3u80A:24.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ugk | SACCHAROPINEDEHYDROGENASE [NAD+,L-LYSINE-FORMING] (Saccharomycescerevisiae) |
PF05222(AlaDh_PNT_N) | 3 | VAL A 26TYR A 51ALA A 54 | None | 0.55A | 4ybnA-3ugkA:undetectable | 4ybnA-3ugkA:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vab | DIAMINOPIMELATEDECARBOXYLASE 1 (Brucellamelitensis) |
PF00278(Orn_DAP_Arg_deC)PF02784(Orn_Arg_deC_N) | 3 | VAL A 194TYR A 183ALA A 186 | None | 0.51A | 4ybnA-3vabA:undetectable | 4ybnA-3vabA:22.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wks | O-PHOSPHO-L-SERYL-TRNA:CYS-TRNA SYNTHASE (Methanocaldococcusjannaschii) |
PF05889(SepSecS) | 3 | VAL A 140TYR A 130ALA A 133 | None | 0.52A | 4ybnA-3wksA:undetectable | 4ybnA-3wksA:18.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zla | NUCLEOPROTEIN (Bunyamweraorthobunyavirus) |
PF00952(Bunya_nucleocap) | 3 | VAL A 208TYR A 158ALA A 161 | None | 0.51A | 4ybnA-3zlaA:undetectable | 4ybnA-3zlaA:20.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zu4 | PUTATIVE REDUCTASEYPO4104/Y4119/YP_4011 (Yersinia pestis) |
PF07055(Eno-Rase_FAD_bd)PF12241(Enoyl_reductase)PF12242(Eno-Rase_NADH_b) | 3 | VAL A 309TYR A 53ALA A 56 | NoneNAI A1400 ( 4.9A)None | 0.54A | 4ybnA-3zu4A:undetectable | 4ybnA-3zu4A:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4awd | BETA-PORPHYRANASE (Bacteroidesplebeius) |
no annotation | 3 | VAL A 47TYR A 26ALA A 29 | None | 0.52A | 4ybnA-4awdA:undetectable | 4ybnA-4awdA:19.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bc7 | ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE,PEROXISOMAL (Cavia porcellus) |
PF01565(FAD_binding_4)PF02913(FAD-oxidase_C) | 3 | VAL A 393TYR A 485ALA A 488 | None | 0.53A | 4ybnA-4bc7A:undetectable | 4ybnA-4bc7A:15.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bhd | SERINEHYDROXYMETHYLTRANSFERASE (Methanocaldococcusjannaschii) |
PF00464(SHMT) | 3 | VAL A 179TYR A 195ALA A 217 | None | 0.56A | 4ybnA-4bhdA:undetectable | 4ybnA-4bhdA:20.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bko | PUTATIVE REDUCTASEBURPS305_1051 (Burkholderiapseudomallei) |
PF07055(Eno-Rase_FAD_bd)PF12241(Enoyl_reductase)PF12242(Eno-Rase_NADH_b) | 3 | VAL A 308TYR A 53ALA A 56 | None | 0.56A | 4ybnA-4bkoA:undetectable | 4ybnA-4bkoA:25.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dez | DNA POLYMERASE IV 1 (Mycolicibacteriumsmegmatis) |
PF00817(IMS) | 3 | VAL A 17TYR A 83ALA A 86 | None | 0.53A | 4ybnA-4dezA:undetectable | 4ybnA-4dezA:22.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dio | NAD(P)TRANSHYDROGENASESUBUNIT ALPHA PART 1 (Sinorhizobiummeliloti) |
PF01262(AlaDh_PNT_C)PF05222(AlaDh_PNT_N) | 3 | VAL A 54TYR A 81ALA A 84 | None | 0.50A | 4ybnA-4dioA:undetectable | 4ybnA-4dioA:18.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e08 | DJ-1 BETA (Drosophilamelanogaster) |
PF01965(DJ-1_PfpI) | 3 | VAL A 24TYR A 159ALA A 162 | None | 0.44A | 4ybnA-4e08A:undetectable | 4ybnA-4e08A:22.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g25 | PENTATRICOPEPTIDEREPEAT-CONTAININGPROTEIN AT2G32230,MITOCHONDRIAL (Arabidopsisthaliana) |
PF16953(PRORP)PF17177(PPR_long) | 3 | VAL A 233TYR A 214ALA A 217 | None | 0.49A | 4ybnA-4g25A:undetectable | 4ybnA-4g25A:19.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gj1 | 1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENEAMINO]IMIDAZOLE-4-CARBOXAMIDE ISOMERASE (Campylobacterjejuni) |
PF00977(His_biosynth) | 3 | VAL A 234TYR A 40ALA A 43 | None | 0.54A | 4ybnA-4gj1A:undetectable | 4ybnA-4gj1A:23.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h5g | AMINO ACID ABCSUPERFAMILY ATPBINDING CASSETTETRANSPORTER, BINDINGPROTEIN (Streptococcuspneumoniae) |
PF00497(SBP_bac_3) | 3 | VAL A 135TYR A 143ALA A 216 | None | 0.52A | 4ybnA-4h5gA:undetectable | 4ybnA-4h5gA:23.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h7u | PYRANOSEDEHYDROGENASE (Leucoagaricusmeleagris) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 3 | VAL A 29TYR A 562ALA A 565 | None | 0.46A | 4ybnA-4h7uA:undetectable | 4ybnA-4h7uA:17.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hzu | PREDICTED MEMBRANEPROTEIN (Lactobacillusbrevis) |
PF07155(ECF-ribofla_trS) | 3 | VAL S 91TYR S 45ALA S 48 | None | 0.47A | 4ybnA-4hzuS:undetectable | 4ybnA-4hzuS:24.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iqr | HEPATOCYTE NUCLEARFACTOR 4-ALPHA (Homo sapiens) |
PF00104(Hormone_recep)PF00105(zf-C4) | 3 | VAL A 306TYR A 279ALA A 282 | None | 0.57A | 4ybnA-4iqrA:undetectable | 4ybnA-4iqrA:19.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j16 | NAD/NADPTRANSHYDROGENASEALPHA SUBUNIT 1 (Thermusthermophilus) |
PF01262(AlaDh_PNT_C)PF05222(AlaDh_PNT_N) | 3 | VAL A 24TYR A 51ALA A 54 | None | 0.57A | 4ybnA-4j16A:undetectable | 4ybnA-4j16A:22.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lc3 | PUTATIVEUDP-4-AMINO-4-DEOXY-L-ARABINOSE--OXOGLUTARATEAMINOTRANSFERASE (Burkholderiacenocepacia) |
PF01041(DegT_DnrJ_EryC1) | 3 | VAL A 371TYR A 264ALA A 267 | None | 0.40A | 4ybnA-4lc3A:undetectable | 4ybnA-4lc3A:21.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n8y | PUTATIVE TRAP-TYPEC4-DICARBOXYLATETRANSPORT SYSTEM,BINDING PERIPLASMICPROTEIN (DCTPSUBUNIT) (Bradyrhizobiumsp. BTAi1) |
PF03480(DctP) | 3 | VAL A 316TYR A 303ALA A 307 | None | 0.50A | 4ybnA-4n8yA:undetectable | 4ybnA-4n8yA:22.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nxk | ABP, A GH27BETA-L-ARABINOPYRANOSIDASE (Geobacillusstearothermophilus) |
PF16499(Melibiase_2) | 3 | VAL A 136TYR A 166ALA A 153 | None | 0.50A | 4ybnA-4nxkA:undetectable | 4ybnA-4nxkA:19.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o3s | DNA POLYMERASE ETA (Homo sapiens) |
PF00817(IMS)PF11799(IMS_C) | 3 | VAL A 21TYR A 92ALA A 95 | None | 0.48A | 4ybnA-4o3sA:undetectable | 4ybnA-4o3sA:19.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pzj | TRANSCRIPTIONALREGULATOR, LYSRFAMILY (Eggerthellalenta) |
PF00126(HTH_1) | 3 | VAL A 32TYR A 18ALA A 21 | None CL A 101 (-4.9A)None | 0.55A | 4ybnA-4pzjA:undetectable | 4ybnA-4pzjA:18.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q22 | GLYCOSIDE HYDROLASEFAMILY 18 (Serratiaproteamaculans) |
PF00704(Glyco_hydro_18) | 3 | VAL A 207TYR A 259ALA A 262 | None | 0.45A | 4ybnA-4q22A:undetectable | 4ybnA-4q22A:22.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ru0 | PUTATIVEBRANCHED-CHAIN AMINOACID ABCTRANSPORTER,PERIPLASMICBRANCHED-CHAIN AMINOACID-BINDING PROTEIN (Pseudomonasprotegens) |
PF13458(Peripla_BP_6) | 3 | VAL A 248TYR A 283ALA A 280 | None | 0.57A | 4ybnA-4ru0A:undetectable | 4ybnA-4ru0A:21.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ru5 | TAILSPIKE GP27 (Pseudomonasphage phi297) |
no annotation | 3 | VAL A 208TYR A 197ALA A 200 | None | 0.57A | 4ybnA-4ru5A:undetectable | 4ybnA-4ru5A:18.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tmd | UNCHARACTERIZEDPROTEIN (Mycolicibacteriumsmegmatis) |
no annotation | 3 | VAL A 209TYR A 174ALA A 101 | None | 0.57A | 4ybnA-4tmdA:undetectable | 4ybnA-4tmdA:22.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tpv | PLATELET INHIBITOR (Ancylostomacaninum) |
PF00188(CAP) | 3 | VAL A 127TYR A 55ALA A 58 | NoneGOL A 201 ( 3.4A)None | 0.44A | 4ybnA-4tpvA:undetectable | 4ybnA-4tpvA:20.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u4p | STRUCTURALMAINTENANCE OFCHROMOSOMES PROTEIN4 (Homo sapiens) |
PF06470(SMC_hinge) | 3 | VAL B 717TYR B 629ALA B 632 | None | 0.51A | 4ybnA-4u4pB:undetectable | 4ybnA-4u4pB:21.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xyw | O-ANTIGENBIOSYNTHESISGLYCOSYLTRANSFERASEWBNH (Escherichiacoli) |
PF00534(Glycos_transf_1)PF13439(Glyco_transf_4) | 3 | VAL A 163TYR A 328ALA A 331 | None | 0.51A | 4ybnA-4xywA:undetectable | 4ybnA-4xywA:20.54 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ybn | FLAVIN-NUCLEOTIDE-BINDING PROTEIN (Mycolicibacteriumsmegmatis) |
PF12900(Pyridox_ox_2) | 3 | VAL A 56TYR A 123ALA A 126 | NoneACT A 303 (-3.7A)ACT A 303 ( 3.9A) | 0.00A | 4ybnA-4ybnA:33.0 | 4ybnA-4ybnA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ynu | GLUCOSE OXIDASE,PUTATIVE (Aspergillusflavus) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 3 | VAL A 19TYR A 554ALA A 557 | None | 0.55A | 4ybnA-4ynuA:undetectable | 4ybnA-4ynuA:18.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bvl | DESIGNED TIM BARRELSTIM11 (syntheticconstruct) |
no annotation | 3 | VAL A 147TYR A 160ALA A 176 | None | 0.57A | 4ybnA-5bvlA:undetectable | 4ybnA-5bvlA:22.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ewp | ARO (ARMADILLOREPEATS ONLYPROTEIN) (Plasmodiumfalciparum) |
no annotation | 3 | VAL A 51TYR A 101ALA A 104 | None | 0.42A | 4ybnA-5ewpA:undetectable | 4ybnA-5ewpA:21.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g4l | OXIDOREDUCTASE,SHORT CHAINDEHYDROGENASE/REDUCTASE FAMILY PROTEIN (Clostridium sp.) |
PF13561(adh_short_C2) | 3 | VAL A 15TYR A 37ALA A 40 | None | 0.57A | 4ybnA-5g4lA:undetectable | 4ybnA-5g4lA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h69 | CHROMOSOME PARTITIONPROTEIN SMC (Geobacillusstearothermophilus) |
PF06470(SMC_hinge) | 3 | VAL A 550TYR A 613ALA A 616 | None | 0.51A | 4ybnA-5h69A:undetectable | 4ybnA-5h69A:24.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h69 | CHROMOSOME PARTITIONPROTEIN SMC (Geobacillusstearothermophilus) |
PF06470(SMC_hinge) | 3 | VAL A 626TYR A 534ALA A 537 | None | 0.56A | 4ybnA-5h69A:undetectable | 4ybnA-5h69A:24.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hdt | SISTER CHROMATIDCOHESION PROTEINPDS5 HOMOLOG B (Homo sapiens) |
no annotation | 3 | VAL A 640TYR A 479ALA A 482 | None | 0.51A | 4ybnA-5hdtA:undetectable | 4ybnA-5hdtA:11.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hj7 | GLUTAMATE RACEMASE (Mycobacteriumtuberculosis) |
PF01177(Asp_Glu_race) | 3 | VAL A 102TYR A 128ALA A 131 | None | 0.42A | 4ybnA-5hj7A:undetectable | 4ybnA-5hj7A:25.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ijl | DNA POLYMERASE IILARGE SUBUNIT (Pyrococcusabyssi) |
PF03833(PolC_DP2) | 3 | VAL A 39TYR A 22ALA A 25 | None | 0.29A | 4ybnA-5ijlA:undetectable | 4ybnA-5ijlA:12.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ijw | GLUTAMATE RACEMASE (Mycolicibacteriumsmegmatis) |
PF01177(Asp_Glu_race) | 3 | VAL A 103TYR A 129ALA A 132 | None | 0.33A | 4ybnA-5ijwA:undetectable | 4ybnA-5ijwA:24.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jta | NEUTRAL TREHALASE (Saccharomycescerevisiae) |
no annotation | 3 | VAL A 206TYR A 238ALA A 241 | None | 0.41A | 4ybnA-5jtaA:undetectable | 4ybnA-5jtaA:15.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m4a | NEUTRAL TREHALASE (Saccharomycescerevisiae) |
no annotation | 3 | VAL A 206TYR A 238ALA A 241 | None | 0.46A | 4ybnA-5m4aA:undetectable | 4ybnA-5m4aA:17.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o67 | FAPF (Pseudomonas sp.UK4) |
no annotation | 3 | VAL B 274TYR B 96ALA B 99 | None | 0.54A | 4ybnA-5o67B:undetectable | 4ybnA-5o67B:22.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5swu | PENTAFUNCTIONAL AROMPOLYPEPTIDE (Aspergillusfumigatus) |
PF01487(DHquinase_I) | 3 | VAL A1152TYR A1141ALA A1144 | None | 0.34A | 4ybnA-5swuA:undetectable | 4ybnA-5swuA:22.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u4q | DTDP-GLUCOSE4,6-DEHYDRATASE (Klebsiellapneumoniae) |
PF16363(GDP_Man_Dehyd) | 3 | VAL A 321TYR A 271ALA A 274 | None | 0.52A | 4ybnA-5u4qA:undetectable | 4ybnA-5u4qA:20.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u7w | APYRASE (Trifoliumrepens) |
PF01150(GDA1_CD39) | 3 | VAL A 38TYR A 387ALA A 390 | None | 0.40A | 4ybnA-5u7wA:undetectable | 4ybnA-5u7wA:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ue0 | CT622 PROTEIN (Chlamydiatrachomatis) |
no annotation | 3 | VAL A 380TYR A 466ALA A 469 | None | 0.50A | 4ybnA-5ue0A:undetectable | 4ybnA-5ue0A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xhq | APOLIPOPROTEINN-ACYLTRANSFERASE (Escherichiacoli) |
PF00795(CN_hydrolase) | 3 | VAL A 227TYR A 249ALA A 252 | None | 0.46A | 4ybnA-5xhqA:undetectable | 4ybnA-5xhqA:19.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xtb | NADH DEHYDROGENASE[UBIQUINONE]IRON-SULFUR PROTEIN4, MITOCHONDRIALNADH-UBIQUINONEOXIDOREDUCTASE 75KDA SUBUNIT,MITOCHONDRIAL (Homo sapiens;Homo sapiens) |
PF04800(ETC_C1_NDUFA4)PF00384(Molybdopterin)PF09326(NADH_dhqG_C)PF10588(NADH-G_4Fe-4S_3)PF13510(Fer2_4) | 3 | VAL M 71TYR L 160ALA M 93 | None | 0.56A | 4ybnA-5xtbM:undetectable | 4ybnA-5xtbM:17.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xyi | RIBOSOMAL PROTEINS19E, PUTATIVE (Trichomonasvaginalis) |
PF01090(Ribosomal_S19e) | 3 | VAL T 35TYR T 61ALA T 64 | None | 0.44A | 4ybnA-5xyiT:undetectable | 4ybnA-5xyiT:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zbl | CYTOKININ RIBOSIDE5'-MONOPHOSPHATEPHOSPHORIBOHYDROLASE (Corynebacteriumglutamicum) |
no annotation | 3 | VAL A 144TYR A 27ALA A 30 | None | 0.48A | 4ybnA-5zblA:undetectable | 4ybnA-5zblA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cwr | - (-) |
no annotation | 3 | VAL A 133TYR A 155ALA A 158 | None | 0.54A | 4ybnA-6cwrA:undetectable | 4ybnA-6cwrA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6d72 | SPERMIDINEN1-ACETYLTRANSFERASE (Yersinia pestis) |
no annotation | 3 | VAL A 7TYR A 99ALA A 102 | None | 0.35A | 4ybnA-6d72A:undetectable | 4ybnA-6d72A:undetectable |