SIMILAR PATTERNS OF AMINO ACIDS FOR 4Y8W_C_STRC603_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a76 FLAP ENDONUCLEASE-1
PROTEIN

(Methanocaldococcus
jannaschii) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		3 LEU A 280
VAL A 305
ASP A 306
 None
 0.38A 4y8wC-1a76A:
0.0		 4y8wC-1a76A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b2h PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Salmonella
enterica) 		PF00496
(SBP_bac_5) 		3 LEU A 293
VAL A 287
ASP A 286
 None
 0.68A 4y8wC-1b2hA:
0.0		 4y8wC-1b2hA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cbg CYANOGENIC
BETA-GLUCOSIDASE

(Trifolium
repens) 		PF00232
(Glyco_hydro_1) 		3 LEU A 236
VAL A 157
ASP A 158
 None
 0.41A 4y8wC-1cbgA:
0.0		 4y8wC-1cbgA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus) 		PF00464
(SHMT) 		3 LEU A 364
VAL A 310
ASP A 322
 None
 0.70A 4y8wC-1cj0A:
0.0		 4y8wC-1cj0A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1db3 GDP-MANNOSE
4,6-DEHYDRATASE

(Escherichia
coli) 		PF16363
(GDP_Man_Dehyd) 		3 LEU A  74
VAL A   3
ASP A  80
 None
 0.71A 4y8wC-1db3A:
0.0		 4y8wC-1db3A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fvp FLAVOPROTEIN 390

(Photobacterium
phosphoreum) 		no annotation 3 LEU A 199
VAL A  44
ASP A  43
 None
 0.67A 4y8wC-1fvpA:
0.0		 4y8wC-1fvpA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3j PEROXIDASE

(Coprinopsis
cinerea) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		3 LEU A 137
VAL A 295
ASP A 294
 None
 0.62A 4y8wC-1h3jA:
1.0		 4y8wC-1h3jA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3q SEDLIN

(Mus musculus) 		PF04628
(Sedlin_N) 		3 LEU A 139
VAL A  89
ASP A  88
 None
 0.54A 4y8wC-1h3qA:
undetectable		 4y8wC-1h3qA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0h NEOPULLULANASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		3 LEU A 298
VAL A 329
ASP A 328
 None
 0.50A 4y8wC-1j0hA:
0.1		 4y8wC-1j0hA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jf5 ALPHA AMYLASE II

(Thermoactinomyces
vulgaris) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		3 LEU A 296
VAL A 326
ASP A 325
 None
 0.38A 4y8wC-1jf5A:
undetectable		 4y8wC-1jf5A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jx2 MYOSIN-2 HEAVY
CHAIN,DYNAMIN-A

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		3 LEU A 436
VAL A 618
ASP A 616
 None
 0.66A 4y8wC-1jx2A:
1.3		 4y8wC-1jx2A:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ldj CULLIN HOMOLOG 1

(Homo sapiens) 		PF00888
(Cullin)
PF10557
(Cullin_Nedd8) 		3 LEU A 775
VAL A 765
ASP A 766
 None
 0.68A 4y8wC-1ldjA:
undetectable		 4y8wC-1ldjA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nvm 4-HYDROXY-2-OXOVALER
ATE ALDOLASE

(Pseudomonas sp.
CF600) 		PF00682
(HMGL-like)
PF07836
(DmpG_comm) 		3 LEU A 140
VAL A 121
ASP A 120
 None
 0.55A 4y8wC-1nvmA:
undetectable		 4y8wC-1nvmA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odo PUTATIVE CYTOCHROME
P450 154A1

(Streptomyces
coelicolor) 		PF00067
(p450) 		3 LEU A 366
VAL A 111
ASP A 112
 None
 0.60A 4y8wC-1odoA:
34.0		 4y8wC-1odoA:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q51 MENB

(Mycobacterium
tuberculosis) 		PF00378
(ECH_1) 		3 LEU A 142
VAL A  66
ASP A  67
 None
 0.66A 4y8wC-1q51A:
undetectable		 4y8wC-1q51A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rfb INTERFERON-GAMMA

(Bos taurus) 		PF00714
(IFN-gamma) 		3 LEU A  28
VAL A  22
ASP A  21
 None
 0.64A 4y8wC-1rfbA:
undetectable		 4y8wC-1rfbA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rvv RIBOFLAVIN SYNTHASE

(Bacillus
subtilis) 		no annotation 3 LEU A   8
VAL A 137
ASP A 138
 None
 0.48A 4y8wC-1rvvA:
undetectable		 4y8wC-1rvvA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sma MALTOGENIC AMYLASE

(Thermus sp.
IM6501) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		3 LEU A 298
VAL A 329
ASP A 328
 None
 0.47A 4y8wC-1smaA:
undetectable		 4y8wC-1smaA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1so8 3-HYDROXYACYL-COA
DEHYDROGENASE TYPE
II

(Homo sapiens) 		PF00106
(adh_short) 		3 LEU A  75
VAL A  12
ASP A  86
 None
 0.67A 4y8wC-1so8A:
undetectable		 4y8wC-1so8A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u7k GAG POLYPROTEIN

(Murine leukemia
virus) 		PF02093
(Gag_p30) 		3 LEU A  72
VAL A  93
ASP A  94
 None
 0.59A 4y8wC-1u7kA:
undetectable		 4y8wC-1u7kA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uaz ARCHAERHODOPSIN-1

(Halorubrum
chaoviator) 		PF01036
(Bac_rhodopsin) 		3 LEU A 103
VAL A 118
ASP A 121
 None
 0.62A 4y8wC-1uazA:
0.0		 4y8wC-1uazA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uok OLIGO-1,6-GLUCOSIDAS
E

(Bacillus cereus) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		3 LEU A 170
VAL A 200
ASP A 199
 None
 0.65A 4y8wC-1uokA:
undetectable		 4y8wC-1uokA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wmr ISOPULLULANASE

(Aspergillus
niger) 		PF03718
(Glyco_hydro_49)
PF17433
(Glyco_hydro_49N) 		3 LEU A  28
VAL A  21
ASP A  71
 None
 0.52A 4y8wC-1wmrA:
undetectable		 4y8wC-1wmrA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wn2 PEPTIDYL-TRNA
HYDROLASE

(Pyrococcus
horikoshii) 		PF01981
(PTH2) 		3 LEU A  71
VAL A 111
ASP A 112
 None
 0.64A 4y8wC-1wn2A:
undetectable		 4y8wC-1wn2A:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x1s RAS-RELATED PROTEIN
M-RAS

(Mus musculus) 		PF00071
(Ras) 		3 LEU A  16
VAL A 164
ASP A 165
 None
 0.71A 4y8wC-1x1sA:
undetectable		 4y8wC-1x1sA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xb2 ELONGATION FACTOR
TS, MITOCHONDRIAL

(Bos taurus) 		PF00889
(EF_TS) 		3 LEU B 169
VAL B 220
ASP B 127
 None
 0.61A 4y8wC-1xb2B:
undetectable		 4y8wC-1xb2B:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xtt PROBABLE URACIL
PHOSPHORIBOSYLTRANSF
ERASE

(Sulfolobus
solfataricus) 		PF14681
(UPRTase) 		3 LEU A  47
VAL A 133
ASP A 134
 None
 0.68A 4y8wC-1xttA:
1.2		 4y8wC-1xttA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y3n ALGQ1

(Sphingomonas
sp. A1) 		PF01547
(SBP_bac_1) 		3 LEU A 242
VAL A 157
ASP A 158
 None
 0.54A 4y8wC-1y3nA:
undetectable		 4y8wC-1y3nA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ycl S-RIBOSYLHOMOCYSTEIN
ASE

(Bacillus
subtilis) 		PF02664
(LuxS) 		3 LEU A 145
VAL A 102
ASP A 103
 None
 0.66A 4y8wC-1yclA:
undetectable		 4y8wC-1yclA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ye9 CATALASE HPII

(Escherichia
coli) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		3 LEU E 552
VAL E 544
ASP E 545
 None
 0.67A 4y8wC-1ye9E:
undetectable		 4y8wC-1ye9E:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yve ACETOHYDROXY ACID
ISOMEROREDUCTASE

(Spinacia
oleracea) 		PF01450
(IlvC)
PF07991
(IlvN) 		3 LEU I 523
VAL I 514
ASP I 515
 None
 0.67A 4y8wC-1yveI:
undetectable		 4y8wC-1yveI:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzp PEROXIDASE
MANGANESE-DEPENDENT
I

(Phanerochaete
chrysosporium) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		3 LEU A 126
VAL A 292
ASP A 291
 None
 0.55A 4y8wC-1yzpA:
0.5		 4y8wC-1yzpA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z72 TRANSCRIPTIONAL
REGULATOR, PUTATIVE

(Streptococcus
pneumoniae) 		PF03070
(TENA_THI-4) 		3 LEU A  12
VAL A 185
ASP A 186
 None
 0.61A 4y8wC-1z72A:
undetectable		 4y8wC-1z72A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zrr E-2/E-2' PROTEIN

(Klebsiella
oxytoca) 		PF03079
(ARD) 		3 LEU A  78
VAL A  75
ASP A  74
 None
 0.61A 4y8wC-1zrrA:
undetectable		 4y8wC-1zrrA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0d 2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE

(Pseudomonas
fluorescens) 		PF00561
(Abhydrolase_1) 		3 LEU A 233
VAL A 227
ASP A 224
 None
 0.63A 4y8wC-2d0dA:
undetectable		 4y8wC-2d0dA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dbb PUTATIVE HTH-TYPE
TRANSCRIPTIONAL
REGULATOR PH0061

(Pyrococcus
horikoshii) 		PF13412
(HTH_24) 		3 LEU A  29
VAL A  10
ASP A  11
 None
 0.56A 4y8wC-2dbbA:
undetectable		 4y8wC-2dbbA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ekf ANCIENT UBIQUITOUS
PROTEIN 1

(Homo sapiens) 		PF02845
(CUE) 		3 LEU A  24
VAL A  42
ASP A  43
 None
 0.61A 4y8wC-2ekfA:
undetectable		 4y8wC-2ekfA:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpo METHYLASE YHHF

(Escherichia
coli) 		PF03602
(Cons_hypoth95) 		3 LEU A  71
VAL A  52
ASP A  53
 None
 0.49A 4y8wC-2fpoA:
undetectable		 4y8wC-2fpoA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g0t CONSERVED
HYPOTHETICAL PROTEIN

(Thermotoga
maritima) 		PF07755
(DUF1611)
PF17396
(DUF1611_N) 		3 LEU A 257
VAL A 159
ASP A 263
 None
 0.52A 4y8wC-2g0tA:
undetectable		 4y8wC-2g0tA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gfn HTH-TYPE
TRANSCRIPTIONAL
REGULATOR PKSA
RELATED PROTEIN

(Rhodococcus
jostii) 		PF00440
(TetR_N)
PF13977
(TetR_C_6) 		3 LEU A 153
VAL A 193
ASP A 194
 None
 0.69A 4y8wC-2gfnA:
undetectable		 4y8wC-2gfnA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h3a CCDA

(Escherichia
coli) 		PF07362
(CcdA) 		3 LEU A  16
VAL A  22
ASP A  21
 None
 0.44A 4y8wC-2h3aA:
undetectable		 4y8wC-2h3aA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)

(Homo sapiens) 		PF03199
(GSH_synthase)
PF03917
(GSH_synth_ATP) 		3 LEU A  32
VAL A  23
ASP A  24
 None
 0.54A 4y8wC-2hgsA:
undetectable		 4y8wC-2hgsA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxv DIAMINOHYDROXYPHOSPH
ORIBOSYLAMINOPYRIMID
INE DEAMINASE/
5-AMINO-6-(5-PHOSPHO
RIBOSYLAMINO)URACIL
REDUCTASE

(Thermotoga
maritima) 		PF00383
(dCMP_cyt_deam_1)
PF01872
(RibD_C) 		3 LEU A 291
VAL A 150
ASP A 295
 None
None
GOL  A 504 (-3.9A)
 0.57A 4y8wC-2hxvA:
undetectable		 4y8wC-2hxvA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2icy PROBABLE
UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2

(Arabidopsis
thaliana) 		PF01704
(UDPGP) 		3 LEU A  76
VAL A  70
ASP A  69
 None
 0.67A 4y8wC-2icyA:
undetectable		 4y8wC-2icyA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jbm NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE

(Homo sapiens) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		3 LEU A 101
VAL A  21
ASP A  22
 None
 0.53A 4y8wC-2jbmA:
undetectable		 4y8wC-2jbmA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kkn UNCHARACTERIZED
PROTEIN

(Thermotoga
maritima) 		PF12850
(Metallophos_2) 		3 LEU A  19
VAL A  40
ASP A  38
 None
 0.57A 4y8wC-2kknA:
undetectable		 4y8wC-2kknA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n3f DOUBLE-STRANDED
RNA-BINDING PROTEIN
4

(Arabidopsis
thaliana) 		PF00035
(dsrm) 		3 LEU A  86
VAL A  81
ASP A  80
 None
 0.45A 4y8wC-2n3fA:
undetectable		 4y8wC-2n3fA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ong 4S-LIMONENE SYNTHASE

(Mentha spicata) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		3 LEU A 514
VAL A 510
ASP A 509
 None
None
MN  A 601 ( 3.6A)
 0.70A 4y8wC-2ongA:
0.7		 4y8wC-2ongA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qs8 XAA-PRO DIPEPTIDASE

(Alteromonas
macleodii) 		PF01979
(Amidohydro_1) 		3 LEU A  62
VAL A 402
ASP A 401
 None
 0.58A 4y8wC-2qs8A:
undetectable		 4y8wC-2qs8A:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rsm PROBABLE PEPTIDE
CHAIN RELEASE FACTOR
C12ORF65 HOMOLOG,
MITOCHONDRIAL

(Mus musculus) 		PF00472
(RF-1) 		3 LEU A  72
VAL A  89
ASP A  90
 None
 0.59A 4y8wC-2rsmA:
undetectable		 4y8wC-2rsmA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v8j PECTATE LYASE

(Yersinia
enterocolitica) 		PF06917
(Pectate_lyase_2) 		3 LEU A 396
VAL A 326
ASP A 327
 None
 0.60A 4y8wC-2v8jA:
undetectable		 4y8wC-2v8jA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsi 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE

(Streptococcus
pneumoniae) 		PF01128
(IspD) 		3 LEU A  71
VAL A  65
ASP A  66
 None
 0.53A 4y8wC-2vsiA:
undetectable		 4y8wC-2vsiA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vw8 PA1000

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B) 		3 LEU A 244
VAL A 189
ASP A 184
 None
 0.64A 4y8wC-2vw8A:
undetectable		 4y8wC-2vw8A:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Homo sapiens) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		3 LEU A 426
VAL A 247
ASP A 248
 None
None
SO4  A1697 (-4.4A)
 0.51A 4y8wC-2vxoA:
undetectable		 4y8wC-2vxoA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vyo POLYSACCHARIDE
DEACETYLASE
DOMAIN-CONTAINING
PROTEIN ECU11_0510

(Encephalitozoon
cuniculi) 		PF01522
(Polysacc_deac_1) 		3 LEU A  85
VAL A  33
ASP A  34
 None
 0.48A 4y8wC-2vyoA:
undetectable		 4y8wC-2vyoA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w2d BOTULINUM NEUROTOXIN
A HEAVY CHAIN

(Clostridium
botulinum) 		PF07952
(Toxin_trans) 		3 LEU B 820
VAL B 834
ASP B 835
 None
SO4  B1872 (-3.4A)
SO4  B1872 (-4.0A)
 0.56A 4y8wC-2w2dB:
undetectable		 4y8wC-2w2dB:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wrt GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME 51

(Fasciola
hepatica) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		3 LEU A 102
VAL A 151
ASP A 152
 None
 0.56A 4y8wC-2wrtA:
undetectable		 4y8wC-2wrtA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xqr INVERTASE INHIBITOR

(Nicotiana
tabacum) 		PF04043
(PMEI) 		3 LEU B  81
VAL B  40
ASP B  41
 EPE  B1000 (-4.0A)
None
None
 0.65A 4y8wC-2xqrB:
undetectable		 4y8wC-2xqrB:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y1l DARPIN-8.4

(synthetic
construct) 		PF12796
(Ank_2)
PF13637
(Ank_4) 		3 LEU E  53
VAL E  40
ASP E  39
 EDO  E1169 (-4.3A)
None
None
 0.71A 4y8wC-2y1lE:
undetectable		 4y8wC-2y1lE:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y4r 4-AMINO-4-DEOXYCHORI
SMATE LYASE

(Pseudomonas
aeruginosa) 		PF01063
(Aminotran_4) 		3 LEU A  81
VAL A   5
ASP A   6
 None
 0.64A 4y8wC-2y4rA:
undetectable		 4y8wC-2y4rA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjq CEL44C

(Paenibacillus
polymyxa) 		PF12891
(Glyco_hydro_44) 		3 LEU A 277
VAL A 209
ASP A 210
 None
 0.65A 4y8wC-2yjqA:
undetectable		 4y8wC-2yjqA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yoc PULLULANASE

(Klebsiella
oxytoca) 		PF02922
(CBM_48)
PF03714
(PUD)
PF11852
(DUF3372) 		3 LEU A 176
VAL A 271
ASP A 274
 None
 0.65A 4y8wC-2yocA:
undetectable		 4y8wC-2yocA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxx DNA REPLICATION
FACTOR CDT1

(Mus musculus) 		PF08839
(CDT1) 		3 LEU C 314
VAL C 349
ASP C 350
 None
 0.63A 4y8wC-2zxxC:
undetectable		 4y8wC-2zxxC:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abz BETA-GLUCOSIDASE I

(Kluyveromyces
marxianus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF07691
(PA14)
PF14310
(Fn3-like) 		3 LEU A  21
VAL A 271
ASP A 272
 None
 0.61A 4y8wC-3abzA:
undetectable		 4y8wC-3abzA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bba INTERPAIN A

(Prevotella
intermedia) 		PF01640
(Peptidase_C10) 		3 LEU A 337
VAL A 328
ASP A 329
 None
 0.52A 4y8wC-3bbaA:
undetectable		 4y8wC-3bbaA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cai POSSIBLE
AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00266
(Aminotran_5) 		3 LEU A 314
VAL A 387
ASP A 388
 None
 0.71A 4y8wC-3caiA:
undetectable		 4y8wC-3caiA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clm TRANSALDOLASE

(Neisseria
gonorrhoeae) 		PF00923
(TAL_FSA) 		3 LEU A  10
VAL A 273
ASP A 274
 None
 0.43A 4y8wC-3clmA:
undetectable		 4y8wC-3clmA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3db2 PUTATIVE
NADPH-DEPENDENT
OXIDOREDUCTASE

(Desulfitobacterium
hafniense) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 LEU A 302
VAL A 299
ASP A 267
 None
 0.68A 4y8wC-3db2A:
undetectable		 4y8wC-3db2A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epj TRNA
ISOPENTENYLTRANSFERA
SE

(Saccharomyces
cerevisiae) 		PF01715
(IPPT) 		3 LEU A 230
VAL A 221
ASP A 222
 None
 0.71A 4y8wC-3epjA:
undetectable		 4y8wC-3epjA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fet ELECTRON TRANSFER
FLAVOPROTEIN SUBUNIT
ALPHA RELATED
PROTEIN

(Thermoplasma
acidophilum) 		PF01012
(ETF) 		3 LEU A 150
VAL A  43
ASP A  27
 None
 0.56A 4y8wC-3fetA:
undetectable		 4y8wC-3fetA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g0o 3-HYDROXYISOBUTYRATE
DEHYDROGENASE

(Salmonella
enterica) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		3 LEU A 269
VAL A 241
ASP A 242
 None
 0.24A 4y8wC-3g0oA:
undetectable		 4y8wC-3g0oA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzd SELENOCYSTEINE LYASE

(Homo sapiens) 		PF00266
(Aminotran_5) 		3 LEU C 216
VAL C 177
ASP C 178
 None
 0.54A 4y8wC-3gzdC:
undetectable		 4y8wC-3gzdC:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h86 ADENYLATE KINASE

(Methanococcus
maripaludis) 		no annotation 3 LEU B 110
VAL B   5
ASP B 116
 None
 0.68A 4y8wC-3h86B:
undetectable		 4y8wC-3h86B:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hf8 TRYPTOPHAN
5-HYDROXYLASE 1

(Homo sapiens) 		PF00351
(Biopterin_H) 		3 LEU A 214
VAL A 256
ASP A 269
 None
 0.69A 4y8wC-3hf8A:
undetectable		 4y8wC-3hf8A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ia4 DIHYDROFOLATE
REDUCTASE

(Moritella
profunda) 		PF00186
(DHFR_1) 		3 LEU A 106
VAL A   3
ASP A 110
 None
 0.47A 4y8wC-3ia4A:
undetectable		 4y8wC-3ia4A:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icj UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE

(Pyrococcus
furiosus) 		PF07969
(Amidohydro_3) 		3 LEU A 386
VAL A 353
ASP A 354
 None
 0.42A 4y8wC-3icjA:
undetectable		 4y8wC-3icjA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ie5 PHENOLIC OXIDATIVE
COUPLING PROTEIN
HYP-1

(Hypericum
perforatum) 		PF00407
(Bet_v_1) 		3 LEU A  69
VAL A  91
ASP A  90
 None
PG4  A 502 ( 4.7A)
None
 0.52A 4y8wC-3ie5A:
undetectable		 4y8wC-3ie5A:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ima CYSTEINE PROTEINASE
INHIBITOR

(Colocasia
esculenta) 		PF16845
(SQAPI) 		3 LEU B  37
VAL B  27
ASP B  28
 None
 0.64A 4y8wC-3imaB:
undetectable		 4y8wC-3imaB:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jd5 28S RIBOSOMAL
PROTEIN S22,
MITOCHONDRIAL

(Bos taurus) 		no annotation 3 LEU a 326
VAL a 293
ASP a 294
 None
 0.57A 4y8wC-3jd5a:
undetectable		 4y8wC-3jd5a:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jx9 PUTATIVE
PHOSPHOHEPTOSE
ISOMERASE

(Exiguobacterium
sibiricum) 		PF10740
(DUF2529) 		3 LEU A  34
VAL A  77
ASP A  78
 None
 0.57A 4y8wC-3jx9A:
undetectable		 4y8wC-3jx9A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ktc XYLOSE ISOMERASE

(Pectobacterium
atrosepticum) 		PF01261
(AP_endonuc_2) 		3 LEU A 193
VAL A 148
ASP A 149
 None
 0.35A 4y8wC-3ktcA:
undetectable		 4y8wC-3ktcA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lev RNA POLYMERASE SIGMA
FACTOR

(Thermus
aquaticus) 		PF04542
(Sigma70_r2) 		3 LEU A 131
VAL A 174
ASP A 175
 None
 0.60A 4y8wC-3levA:
3.1		 4y8wC-3levA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lfl GLUTATHIONE
S-TRANSFERASE
OMEGA-1

(Homo sapiens) 		PF13417
(GST_N_3)
PF14497
(GST_C_3) 		3 LEU A 200
VAL A 192
ASP A 193
 None
 0.62A 4y8wC-3lflA:
undetectable		 4y8wC-3lflA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my7 ALCOHOL
DEHYDROGENASE/ACETAL
DEHYDE DEHYDROGENASE

(Vibrio
parahaemolyticus) 		PF00171
(Aldedh) 		3 LEU A 125
VAL A  31
ASP A  32
 None
 0.70A 4y8wC-3my7A:
undetectable		 4y8wC-3my7A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2o BIOSYNTHETIC
ARGININE
DECARBOXYLASE

(Vibrio
vulnificus) 		PF02784
(Orn_Arg_deC_N) 		3 LEU A 128
VAL A 113
ASP A 114
 None
 0.56A 4y8wC-3n2oA:
undetectable		 4y8wC-3n2oA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2t PUTATIVE
OXIDOREDUCTASE

(Gluconobacter
oxydans) 		PF00248
(Aldo_ket_red) 		3 LEU A 116
VAL A  81
ASP A 125
 None
 0.68A 4y8wC-3n2tA:
undetectable		 4y8wC-3n2tA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ngh PDZ
DOMAIN-CONTAINING
PROTEIN 1

(Mus musculus) 		PF00595
(PDZ) 		3 LEU A  24
VAL A  37
ASP A  51
 None
 0.70A 4y8wC-3nghA:
undetectable		 4y8wC-3nghA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oka GDP-MANNOSE-DEPENDEN
T
ALPHA-(1-6)-PHOSPHAT
IDYLINOSITOL
MONOMANNOSIDE
MANNOSYLTRANSFERASE

(Corynebacterium
glutamicum) 		PF00534
(Glycos_transf_1)
PF13439
(Glyco_transf_4) 		3 LEU A 270
VAL A 200
ASP A 274
 None
 0.59A 4y8wC-3okaA:
undetectable		 4y8wC-3okaA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p24 BFT-3

(Bacteroides
fragilis) 		PF13583
(Reprolysin_4)
PF16376
(fragilysinNterm) 		3 LEU A 186
VAL A 177
ASP A 178
 None
None
GOL  A 505 ( 3.6A)
 0.62A 4y8wC-3p24A:
undetectable		 4y8wC-3p24A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pwx PUTATIVE FLAGELLAR
HOOK-ASSOCIATED
PROTEIN

(Vibrio
parahaemolyticus) 		PF00669
(Flagellin_N) 		3 LEU A  49
VAL A 254
ASP A 255
 None
 0.49A 4y8wC-3pwxA:
1.4		 4y8wC-3pwxA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3u LIGNIN PEROXIDASE

(Trametopsis
cervina) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		3 LEU A 129
VAL A 286
ASP A 285
 None
 0.61A 4y8wC-3q3uA:
undetectable		 4y8wC-3q3uA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rpl D-FRUCTOSE
1,6-BISPHOSPHATASE
CLASS
2/SEDOHEPTULOSE
1,7-BISPHOSPHATASE

(Synechocystis
sp. PCC 6803) 		PF03320
(FBPase_glpX) 		3 LEU A 104
VAL A 201
ASP A 200
 None
None
FBP  A 350 (-2.8A)
 0.69A 4y8wC-3rplA:
undetectable		 4y8wC-3rplA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t1b TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY

(Vibrio cholerae) 		PF00126
(HTH_1)
PF03466
(LysR_substrate) 		3 LEU A 220
VAL A 239
ASP A 238
 None
 0.50A 4y8wC-3t1bA:
undetectable		 4y8wC-3t1bA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3to9 HISTONE
ACETYLTRANSFERASE
ESA1

(Saccharomyces
cerevisiae) 		PF01853
(MOZ_SAS) 		3 LEU A 272
VAL A 268
ASP A 269
 None
 0.57A 4y8wC-3to9A:
undetectable		 4y8wC-3to9A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqi GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Coxiella
burnetii) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		3 LEU A 386
VAL A 238
ASP A 239
 None
 0.54A 4y8wC-3tqiA:
undetectable		 4y8wC-3tqiA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqi GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Coxiella
burnetii) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		3 LEU A 390
VAL A 238
ASP A 239
 None
 0.65A 4y8wC-3tqiA:
undetectable		 4y8wC-3tqiA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ty4 PROBABLE
HOMOISOCITRATE
DEHYDROGENASE

(Schizosaccharomyces
pombe) 		PF00180
(Iso_dh) 		3 LEU A 339
VAL A 329
ASP A 330
 None
 0.56A 4y8wC-3ty4A:
undetectable		 4y8wC-3ty4A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u5u RAUCAFFRICINE-O-BETA
-D-GLUCOSIDASE

(Rauvolfia
serpentina) 		PF00232
(Glyco_hydro_1) 		3 LEU A 256
VAL A 160
ASP A 161
 None
 0.49A 4y8wC-3u5uA:
undetectable		 4y8wC-3u5uA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3usc HYDROGENASE-1 LARGE
CHAIN

(Escherichia
coli) 		PF00374
(NiFeSe_Hases) 		3 LEU L 417
VAL L 428
ASP L 432
 None
 0.64A 4y8wC-3uscL:
1.0		 4y8wC-3uscL:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v0t PERAKINE REDUCTASE

(Rauvolfia
serpentina) 		PF00248
(Aldo_ket_red) 		3 LEU A 112
VAL A  81
ASP A 121
 None
 0.68A 4y8wC-3v0tA:
undetectable		 4y8wC-3v0tA:
21.66