SIMILAR PATTERNS OF AMINO ACIDS FOR 4Y8W_C_STRC603_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b33 ALLOPHYCOCYANIN,
ALPHA CHAIN

(Mastigocladus
laminosus) 		PF00502
(Phycobilisome) 		5 VAL A 111
ILE A 108
ILE A 122
VAL A  64
LEU A  57
 None
None
None
BLA  A 201 (-4.0A)
None
 0.90A 4y8wC-1b33A:
0.6		 4y8wC-1b33A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7j PROTEIN
(PARA-NITROBENZYL
ESTERASE)

(Bacillus
subtilis) 		PF00135
(COesterase) 		5 LEU A 166
ILE A 300
ILE A 195
GLY A 191
LEU A 134
 None
 1.02A 4y8wC-1c7jA:
0.0		 4y8wC-1c7jA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cja PROTEIN
(ACTIN-FRAGMIN
KINASE)

(Physarum
polycephalum) 		PF09192
(Act-Frag_cataly) 		5 LEU A 153
VAL A 125
ILE A 103
GLY A 133
LEU A 140
 None
 0.95A 4y8wC-1cjaA:
0.1		 4y8wC-1cjaA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dlk THROMBIN HEAVY CHAIN

(Bos taurus) 		PF00089
(Trypsin) 		6 VAL B 238
LEU B 105
VAL B 231
ILE B 212
GLY B 196
VAL B  31
 None
 1.44A 4y8wC-1dlkB:
undetectable		 4y8wC-1dlkB:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezi CMP-N-ACETYLNEURAMIN
IC ACID SYNTHETASE

(Neisseria
meningitidis) 		PF02348
(CTP_transf_3) 		5 VAL A  66
ILE A  49
ILE A  36
GLY A  33
LEU A  23
 None
 1.03A 4y8wC-1eziA:
0.0		 4y8wC-1eziA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j71 ASPARTIC PROTEINASE

(Candida
tropicalis) 		PF00026
(Asp) 		5 VAL A  29
ILE A  18
GLY A 100
VAL A   3
LEU A 145
 None
None
None
EOH  A 572 ( 4.2A)
None
 0.87A 4y8wC-1j71A:
0.0		 4y8wC-1j71A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kyh HYPOTHETICAL 29.9
KDA PROTEIN IN
SIGY-CYDD INTERGENIC
REGION

(Bacillus
subtilis) 		PF01256
(Carb_kinase) 		5 VAL A 144
LEU A 146
VAL A 118
ILE A 101
GLY A 102
 None
 1.00A 4y8wC-1kyhA:
0.0		 4y8wC-1kyhA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1llu ALCOHOL
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 SER A  41
LEU A 340
ILE A  21
ILE A  64
GLY A 124
 None
 1.00A 4y8wC-1lluA:
0.0		 4y8wC-1lluA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sc6 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Escherichia
coli) 		PF00389
(2-Hacid_dh)
PF01842
(ACT)
PF02826
(2-Hacid_dh_C) 		5 SER A 208
ILE A 293
ILE A 162
GLY A 163
LEU A 154
 None
None
NAD  A2101 (-3.9A)
None
None
 0.97A 4y8wC-1sc6A:
0.0		 4y8wC-1sc6A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tr7 FIMH PROTEIN

(Escherichia
coli) 		no annotation 5 VAL B  20
ILE B  42
ILE B 148
VAL B 154
LEU B  34
 None
 1.02A 4y8wC-1tr7B:
undetectable		 4y8wC-1tr7B:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xez HEMOLYSIN

(Vibrio cholerae) 		PF07968
(Leukocidin)
PF12563
(Hemolysin_N)
PF16458
(Beta-prism_lec) 		6 VAL A 711
VAL A 708
ILE A 701
ILE A 616
GLY A 675
VAL A 680
 None
 1.43A 4y8wC-1xezA:
undetectable		 4y8wC-1xezA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zap SECRETED ASPARTIC
PROTEINASE

(Candida
albicans) 		PF00026
(Asp) 		5 VAL A  29
ILE A  18
GLY A 100
VAL A   3
LEU A 144
 None
 0.84A 4y8wC-1zapA:
undetectable		 4y8wC-1zapA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b67 COG0778:
NITROREDUCTASE

(Streptococcus
pneumoniae) 		PF00881
(Nitroreductase) 		5 VAL A 179
ILE A  76
ILE A 148
GLY A 147
LEU A   6
 None
 0.97A 4y8wC-2b67A:
undetectable		 4y8wC-2b67A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bb6 TRANSCOBALAMIN II

(Bos taurus) 		PF01122
(Cobalamin_bind) 		5 VAL A 158
ILE A 204
ILE A 143
GLY A 142
VAL A 110
 None
 0.98A 4y8wC-2bb6A:
undetectable		 4y8wC-2bb6A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bs9 BETA-XYLOSIDASE

(Geobacillus
stearothermophilus) 		PF01229
(Glyco_hydro_39) 		5 LEU A 107
VAL A 137
ILE A 134
ILE A  63
GLY A  62
 None
 0.96A 4y8wC-2bs9A:
undetectable		 4y8wC-2bs9A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bwm PSATHYRELLA VELUTINA
LECTIN PVL

(Lacrymaria
velutina) 		PF13517
(VCBS) 		5 VAL A 341
VAL A 305
ILE A 352
VAL A 250
LEU A 243
 None
 1.02A 4y8wC-2bwmA:
undetectable		 4y8wC-2bwmA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cdu NADPH OXIDASE

(Lactobacillus
sanfranciscensis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 VAL A 130
LEU A 132
ILE A 224
ILE A 155
GLY A 156
 None
None
None
None
ADP  A 501 (-3.4A)
 0.97A 4y8wC-2cduA:
undetectable		 4y8wC-2cduA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3y URACIL-DNA
GLYCOSYLASE

(Thermus
thermophilus) 		PF03167
(UDG) 		5 ASP A  75
SER A  77
VAL A  43
GLY A  57
LEU A  81
 ACT  A 222 ( 4.9A)
ACT  A 222 ( 4.2A)
None
ACT  A 222 ( 4.7A)
None
 0.94A 4y8wC-2d3yA:
undetectable		 4y8wC-2d3yA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2de2 DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME B

(Rhodococcus sp.
IGTS8) 		no annotation 5 VAL A 124
LEU A 160
VAL A 219
ILE A 179
LEU A 164
 None
 0.94A 4y8wC-2de2A:
undetectable		 4y8wC-2de2A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dib FILAMIN-B

(Homo sapiens) 		PF00630
(Filamin) 		5 VAL A  99
VAL A  26
ILE A 106
ILE A  31
GLY A  30
 None
 0.94A 4y8wC-2dibA:
undetectable		 4y8wC-2dibA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h6t CANDIDAPEPSIN-3

(Candida
albicans) 		PF00026
(Asp) 		5 VAL A  29
ILE A  18
GLY A 100
VAL A   3
LEU A 144
 None
 0.83A 4y8wC-2h6tA:
undetectable		 4y8wC-2h6tA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ihs CG2944-PF, ISOFORM F

(Drosophila
melanogaster) 		PF00622
(SPRY) 		6 VAL A 183
LEU A 192
VAL A 217
ILE A 106
GLY A 138
LEU A 208
 None
 1.43A 4y8wC-2ihsA:
undetectable		 4y8wC-2ihsA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2in2 PICORNAIN 3C

(Rhinovirus B) 		PF00548
(Peptidase_C3) 		5 VAL A 149
LEU A  10
VAL A  36
ILE A 159
ILE A  30
 None
 1.02A 4y8wC-2in2A:
undetectable		 4y8wC-2in2A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nuu NITROGEN REGULATORY
PROTEIN P-II 2

(Escherichia
coli) 		PF00543
(P-II) 		5 VAL G  73
VAL G  93
ILE G  74
VAL G  99
LEU G 112
 None
None
None
None
ADP  G1200 ( 4.2A)
 0.88A 4y8wC-2nuuG:
undetectable		 4y8wC-2nuuG:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2onf HYPOTHETICAL PROTEIN
TA0195

(Thermoplasma
acidophilum) 		PF02566
(OsmC) 		5 LEU A  59
VAL A 101
ILE A  99
ILE A  67
GLY A  66
 None
 1.00A 4y8wC-2onfA:
undetectable		 4y8wC-2onfA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ox4 PUTATIVE MANDELATE
RACEMASE

(Zymomonas
mobilis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 VAL A 179
LEU A 181
ILE A 192
GLY A 193
VAL A 212
 None
 1.02A 4y8wC-2ox4A:
undetectable		 4y8wC-2ox4A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oze ORF DELTA'

(Streptococcus
pyogenes) 		PF13614
(AAA_31) 		5 LEU A 212
ILE A  37
ILE A 215
GLY A 216
LEU A 201
 None
 0.75A 4y8wC-2ozeA:
undetectable		 4y8wC-2ozeA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p8u HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
CYTOPLASMIC

(Homo sapiens) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		5 LEU A  68
VAL A 162
ARG A 430
GLY A  57
VAL A 337
 None
 1.00A 4y8wC-2p8uA:
undetectable		 4y8wC-2p8uA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pjz HYPOTHETICAL PROTEIN
ST1066

(Sulfurisphaera
tokodaii) 		PF00005
(ABC_tran) 		5 LEU A 254
VAL A 237
ILE A 260
ILE A 232
GLY A 201
 None
 0.98A 4y8wC-2pjzA:
undetectable		 4y8wC-2pjzA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzx CANDIDAPEPSIN-5

(Candida
albicans) 		PF00026
(Asp) 		5 VAL A  29
ILE A  18
GLY A 100
VAL A   3
LEU A 144
 None
 0.87A 4y8wC-2qzxA:
undetectable		 4y8wC-2qzxA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v8j PECTATE LYASE

(Yersinia
enterocolitica) 		PF06917
(Pectate_lyase_2) 		5 SER A 301
LEU A 305
ILE A 485
GLY A 378
VAL A 400
 None
 0.84A 4y8wC-2v8jA:
undetectable		 4y8wC-2v8jA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abb CYTOCHROME P450
HYDROXYLASE

(Streptomyces
avermitilis) 		PF00067
(p450) 		5 VAL A 129
ILE A 252
GLY A 255
VAL A 279
LEU A 269
 None
 1.00A 4y8wC-3abbA:
34.4		 4y8wC-3abbA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjs MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Polaromonas sp.
JS666) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 VAL A 249
VAL A 217
ILE A 253
ILE A 206
GLY A 207
 None
 1.00A 4y8wC-3bjsA:
undetectable		 4y8wC-3bjsA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3enq RIBOSE-5-PHOSPHATE
ISOMERASE A

(Vibrio
vulnificus) 		PF06026
(Rib_5-P_isom_A) 		5 VAL A 106
VAL A  73
ILE A 109
ILE A  23
GLY A  48
 None
 1.01A 4y8wC-3enqA:
undetectable		 4y8wC-3enqA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fnr ARGINYL-TRNA
SYNTHETASE

(Campylobacter
jejuni) 		PF00750
(tRNA-synt_1d)
PF05746
(DALR_1) 		5 LEU A 395
VAL A 373
ILE A 399
ILE A 121
GLY A 122
 None
 1.00A 4y8wC-3fnrA:
2.2		 4y8wC-3fnrA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hsy GLUTAMATE RECEPTOR 2

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		5 VAL A 285
ILE A  91
ILE A 339
GLY A 337
VAL A 249
 None
 1.03A 4y8wC-3hsyA:
undetectable		 4y8wC-3hsyA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus) 		PF01048
(PNP_UDP_1) 		5 VAL A  70
VAL A 272
ILE A 276
ILE A  35
GLY A  33
 None
 0.91A 4y8wC-3khsA:
undetectable		 4y8wC-3khsA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvn UDP-N-ACETYLMURAMATE
:L-ALANYL-GAMMA-D-GL
UTAMYL-MEDO-DIAMINOP
IMELATE LIGASE

([Haemophilus]
ducreyi) 		PF02875
(Mur_ligase_C) 		5 VAL A 329
ASP A 331
ILE A 432
ILE A 443
GLY A 441
 None
 1.02A 4y8wC-3mvnA:
undetectable		 4y8wC-3mvnA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ne5 CATION EFFLUX SYSTEM
PROTEIN CUSA

(Escherichia
coli) 		PF00873
(ACR_tran) 		5 LEU A 467
VAL A1008
ILE A1012
GLY A 929
LEU A 872
 None
 1.03A 4y8wC-3ne5A:
1.8		 4y8wC-3ne5A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qdq 4-HYDROXYBUTYRATE
COA-TRANSFERASE

(Clostridium
aminobutyricum) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		5 VAL A 244
LEU A 214
VAL A 286
ILE A 267
VAL A 300
 None
 0.94A 4y8wC-3qdqA:
undetectable		 4y8wC-3qdqA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qlj SHORT CHAIN
DEHYDROGENASE

(Mycobacterium
avium) 		PF00106
(adh_short) 		5 VAL A 231
ILE A 199
ILE A  18
GLY A  17
VAL A  56
 None
 1.02A 4y8wC-3qljA:
undetectable		 4y8wC-3qljA:
21.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qz1 STEROID
21-HYDROXYLASE

(Bos taurus) 		PF00067
(p450) 		6 VAL A 101
ASP A 107
SER A 109
ARG A 232
VAL A 358
LEU A 362
 None
None
3QZ  A 501 (-3.8A)
3QZ  A 501 (-3.8A)
HEM  A 500 (-4.3A)
HEM  A 500 (-4.7A)
 0.95A 4y8wC-3qz1A:
52.0		 4y8wC-3qz1A:
75.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qz1 STEROID
21-HYDROXYLASE

(Bos taurus) 		PF00067
(p450) 		5 VAL A 101
SER A 109
LEU A 110
GLY A 290
VAL A 469
 None
3QZ  A 501 (-3.8A)
3QZ  A 501 (-4.3A)
3QZ  A 501 (-3.9A)
None
 1.03A 4y8wC-3qz1A:
52.0		 4y8wC-3qz1A:
75.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qz1 STEROID
21-HYDROXYLASE

(Bos taurus) 		PF00067
(p450) 		8 VAL A 101
SER A 109
LEU A 110
TRP A 200
ILE A 229
ARG A 232
VAL A 358
LEU A 362
 None
3QZ  A 501 (-3.8A)
3QZ  A 501 (-4.3A)
3QZ  A 501 (-4.1A)
None
3QZ  A 501 (-3.8A)
HEM  A 500 (-4.3A)
HEM  A 500 (-4.7A)
 0.91A 4y8wC-3qz1A:
52.0		 4y8wC-3qz1A:
75.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qz1 STEROID
21-HYDROXYLASE

(Bos taurus) 		PF00067
(p450) 		6 VAL A 101
SER A 109
LEU A 110
TRP A 200
ILE A 229
GLY A 290
 None
3QZ  A 501 (-3.8A)
3QZ  A 501 (-4.3A)
3QZ  A 501 (-4.1A)
None
3QZ  A 501 (-3.9A)
 1.18A 4y8wC-3qz1A:
52.0		 4y8wC-3qz1A:
75.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r6m YEAZ, RESUSCITATION
PROMOTING FACTOR

(Vibrio
parahaemolyticus) 		PF00814
(Peptidase_M22) 		5 VAL A  16
LEU A   5
ILE A  78
GLY A  81
LEU A  54
 None
 1.02A 4y8wC-3r6mA:
undetectable		 4y8wC-3r6mA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s2g ZINC-CONTAINING
ALCOHOL
DEHYDROGENASE
SUPERFAMILY

(Cupriavidus
pinatubonensis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 SER A  39
LEU A 338
VAL A   9
ILE A  62
GLY A 122
 None
 1.02A 4y8wC-3s2gA:
undetectable		 4y8wC-3s2gA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tha TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Campylobacter
jejuni) 		PF00290
(Trp_syntA) 		5 VAL A 217
LEU A 184
VAL A 221
ILE A 205
GLY A 204
 None
 0.88A 4y8wC-3thaA:
undetectable		 4y8wC-3thaA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u12 USP37 PROTEIN

(Homo sapiens) 		PF16674
(UCH_N) 		5 ASP A  78
SER A  80
LEU A  76
VAL A  40
LEU A  82
 UNX  A1017 ( 3.8A)
UNX  A1017 ( 2.9A)
None
None
None
 1.01A 4y8wC-3u12A:
undetectable		 4y8wC-3u12A:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4o MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1

(Homo sapiens) 		PF00656
(Peptidase_C14) 		5 LEU A 515
VAL A 487
ILE A 550
ILE A 525
LEU A 369
 None
 0.94A 4y8wC-3v4oA:
undetectable		 4y8wC-3v4oA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vu4 KMHSV2

(Kluyveromyces
marxianus) 		no annotation 5 VAL A 196
LEU A 198
ILE A 193
ILE A 186
GLY A 223
 None
 0.98A 4y8wC-3vu4A:
undetectable		 4y8wC-3vu4A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wrv TM-1 PROTEIN

(Solanum
lycopersicum) 		PF06792
(UPF0261) 		5 VAL A 195
VAL A  31
ILE A 120
GLY A 121
LEU A 107
 None
 0.96A 4y8wC-3wrvA:
undetectable		 4y8wC-3wrvA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a01 PROTON
PYROPHOSPHATASE

(Vigna radiata) 		PF03030
(H_PPase) 		5 ASP A 294
SER A 298
LEU A 295
ILE A 545
LEU A 490
 None
 0.96A 4y8wC-4a01A:
0.8		 4y8wC-4a01A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae) 		PF01926
(MMR_HSR1)
PF02824
(TGS)
PF16897
(MMR_HSR1_Xtn) 		5 SER A  75
VAL A 248
ILE A 272
ILE A 149
GLY A  72
 None
 0.98A 4y8wC-4a9aA:
undetectable		 4y8wC-4a9aA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4av6 K(+)-STIMULATED
PYROPHOSPHATE-ENERGI
ZED SODIUM PUMP

(Thermotoga
maritima) 		PF03030
(H_PPase) 		5 ASP A 243
SER A 247
LEU A 244
ILE A 503
LEU A 448
 None
 1.02A 4y8wC-4av6A:
undetectable		 4y8wC-4av6A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cpn NEURAMINIDASE

(Influenza B
virus) 		PF00064
(Neur) 		5 LEU A 221
VAL A 203
ILE A 260
ILE A 190
GLY A 178
 None
 0.91A 4y8wC-4cpnA:
undetectable		 4y8wC-4cpnA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvc ALCOHOL
DEHYDROGENASE

(Pseudogluconobacter
saccharoketogenes) 		PF13360
(PQQ_2) 		5 ASP A 330
SER A 334
LEU A 327
ILE A 420
VAL A 399
 None
 0.92A 4y8wC-4cvcA:
undetectable		 4y8wC-4cvcA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4egf L-XYLULOSE REDUCTASE

(Mycolicibacterium
smegmatis) 		PF13561
(adh_short_C2) 		5 LEU A  43
VAL A 237
ILE A  32
GLY A  29
LEU A  60
 None
 1.03A 4y8wC-4egfA:
undetectable		 4y8wC-4egfA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gij PSEUDOURIDINE-5'-PHO
SPHATE GLYCOSIDASE

(Escherichia
coli) 		PF04227
(Indigoidine_A) 		5 VAL A  91
SER A  32
LEU A  84
VAL A 102
LEU A  76
 None
 1.00A 4y8wC-4gijA:
undetectable		 4y8wC-4gijA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gou EHRGS-RHOGEF

(Entamoeba
histolytica) 		PF00615
(RGS)
PF00621
(RhoGEF) 		5 LEU A 400
ILE A 474
ILE A 438
VAL A 450
LEU A 389
 None
 0.99A 4y8wC-4gouA:
undetectable		 4y8wC-4gouA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gx7 CYTOLYSIN AND
HEMOLYSIN HLYA
PORE-FORMING TOXIN

(Vibrio cholerae) 		PF16458
(Beta-prism_lec) 		6 VAL A 711
VAL A 708
ILE A 701
ILE A 616
GLY A 675
VAL A 680
 None
 1.46A 4y8wC-4gx7A:
undetectable		 4y8wC-4gx7A:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h16 SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		5 VAL A  79
LEU A   7
VAL A 133
ILE A 233
LEU A   5
 None
 1.02A 4y8wC-4h16A:
undetectable		 4y8wC-4h16A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hcj THIJ/PFPI DOMAIN
PROTEIN

(Brachyspira
murdochii) 		PF01965
(DJ-1_PfpI) 		5 ASP A 128
SER A 106
LEU A 125
ILE A  76
GLY A  77
 None
 0.97A 4y8wC-4hcjA:
undetectable		 4y8wC-4hcjA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1p MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1

(Homo sapiens) 		PF00656
(Peptidase_C14) 		5 LEU A 515
VAL A 487
ILE A 550
ILE A 525
LEU A 369
 None
 0.96A 4y8wC-4i1pA:
undetectable		 4y8wC-4i1pA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jkl BETA-GLUCURONIDASE

(Streptococcus
agalactiae) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		6 VAL A 401
SER A 324
LEU A 346
VAL A 458
ILE A 498
GLY A 542
 None
 1.40A 4y8wC-4jklA:
undetectable		 4y8wC-4jklA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kq6 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE

([Candida]
glabrata) 		PF00885
(DMRL_synthase) 		5 SER A  68
VAL A  36
ILE A  32
ILE A  22
GLY A  21
 None
 0.84A 4y8wC-4kq6A:
undetectable		 4y8wC-4kq6A:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kq8 CYTOCHROME P450 19A1

(Homo sapiens) 		PF00067
(p450) 		5 LEU A 319
ILE A 333
ARG A 495
VAL A 194
LEU A 191
 None
 1.01A 4y8wC-4kq8A:
37.9		 4y8wC-4kq8A:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7w PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Leptotrichia
buccalis) 		PF01048
(PNP_UDP_1) 		5 SER A 131
LEU A 134
VAL A  83
ILE A  17
GLY A 194
 None
 0.96A 4y8wC-4m7wA:
undetectable		 4y8wC-4m7wA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n7t PHOSPHOPENTOMUTASE

(Streptococcus
mutans) 		PF01676
(Metalloenzyme) 		5 ASP A 318
ILE A 324
ILE A  56
GLY A  57
LEU A  39
 None
 1.02A 4y8wC-4n7tA:
undetectable		 4y8wC-4n7tA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4na3 POLYKETIDE SYNTHASE
PKSJ

(Bacillus
subtilis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 LEU A 375
VAL A 246
ILE A 367
ILE A   9
GLY A 263
 None
 0.94A 4y8wC-4na3A:
undetectable		 4y8wC-4na3A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 LEU A3510
VAL A3390
ILE A3502
ILE A3145
GLY A3407
 None
 0.88A 4y8wC-4tktA:
undetectable		 4y8wC-4tktA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		5 VAL A 328
ILE A 272
GLY A 301
VAL A 242
LEU A 333
 None
 1.01A 4y8wC-4wboA:
1.4		 4y8wC-4wboA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9v PARTICLE-ASSOCIATED
LYASE

(Acinetobacter
virus AP22) 		no annotation 5 SER A 505
TRP A 575
ILE A 591
ILE A 541
GLY A 509
 None
 0.93A 4y8wC-4y9vA:
undetectable		 4y8wC-4y9vA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0t OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY

(Brucella ovis) 		PF00106
(adh_short) 		5 SER A 160
ILE A  65
ILE A  94
GLY A  96
VAL A 104
 None
BR  A 305 ( 4.0A)
None
None
None
 1.02A 4y8wC-4z0tA:
undetectable		 4y8wC-4z0tA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0t OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY

(Brucella ovis) 		PF00106
(adh_short) 		5 VAL A 185
VAL A 213
ILE A  19
GLY A  20
VAL A  34
 None
None
BR  A 304 (-4.5A)
None
None
 0.99A 4y8wC-4z0tA:
undetectable		 4y8wC-4z0tA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 LEU A2686
VAL A2566
ILE A2678
ILE A2325
GLY A2583
 None
 0.88A 4y8wC-4z37A:
undetectable		 4y8wC-4z37A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 SER A2418
VAL A2681
ILE A2325
ILE A2678
VAL A2387
 None
 0.85A 4y8wC-4z37A:
undetectable		 4y8wC-4z37A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ejb FUSION GLYCOPROTEIN
F0

(Hendra
henipavirus) 		no annotation 5 LEU B 210
VAL B 269
ILE B 266
GLY B  85
LEU B 207
 None
 0.95A 4y8wC-5ejbB:
undetectable		 4y8wC-5ejbB:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5erb POLYKETIDE SYNTHASE

(Bacillus
amyloliquefaciens) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 LEU A 373
VAL A 253
ILE A 365
ILE A  11
GLY A 270
 None
 1.02A 4y8wC-5erbA:
undetectable		 4y8wC-5erbA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae) 		PF08704
(GCD14) 		5 SER B 137
LEU B 135
VAL B  94
ILE B 102
GLY B 120
 None
None
SAM  B 401 (-3.8A)
None
SAM  B 401 (-3.3A)
 1.03A 4y8wC-5ergB:
undetectable		 4y8wC-5ergB:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f38 ACETYL-COA
ACETYLTRANSFERASE

(Escherichia
coli) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 VAL B  95
LEU B  92
ILE B 259
ILE B 390
GLY B 374
 None
 0.97A 4y8wC-5f38B:
undetectable		 4y8wC-5f38B:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fod LEUCYL-TRNA
SYNTHETASE

(Plasmodium
falciparum) 		no annotation 5 SER A 457
LEU A 461
ILE A 390
ILE A 567
GLY A 566
 None
 1.00A 4y8wC-5fodA:
undetectable		 4y8wC-5fodA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ilq ASPARTATE
CARBAMOYLTRANSFERASE

(Plasmodium
falciparum) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 VAL A 344
LEU A 321
ILE A 315
VAL A 245
LEU A 285
 None
 0.73A 4y8wC-5ilqA:
undetectable		 4y8wC-5ilqA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5d 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE

(Mycobacterium
tuberculosis) 		PF00701
(DHDPS) 		5 VAL A 244
ASP A 196
SER A 212
VAL A 298
LEU A  15
 None
 0.96A 4y8wC-5j5dA:
undetectable		 4y8wC-5j5dA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j7u MAJOR CAPSID PROTEIN

(Faustovirus) 		PF04451
(Capsid_NCLDV) 		5 VAL A 424
ILE A 609
GLY A 449
VAL A 526
LEU A 568
 None
 0.95A 4y8wC-5j7uA:
undetectable		 4y8wC-5j7uA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxr CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN

(Thermothelomyces
thermophila) 		PF00176
(SNF2_N)
PF00271
(Helicase_C) 		5 VAL A 457
LEU A 454
VAL A 624
ILE A 620
GLY A 169
 None
 0.96A 4y8wC-5jxrA:
undetectable		 4y8wC-5jxrA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdx METALLOPEPTIDASE

(Pseudomonas
aeruginosa) 		PF13402
(Peptidase_M60) 		5 VAL A 588
LEU A 579
ILE A 664
GLY A 597
LEU A 571
 None
 1.01A 4y8wC-5kdxA:
undetectable		 4y8wC-5kdxA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kuf GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
2

(Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		6 VAL A 298
ILE A  99
ILE A 344
GLY A 342
VAL A 258
LEU A 251
 None
 1.43A 4y8wC-5kufA:
undetectable		 4y8wC-5kufA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kum ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 12

(Gallus gallus) 		PF01007
(IRK) 		5 SER A 278
ILE A 321
ILE A 283
GLY A 282
VAL A 363
 None
 1.02A 4y8wC-5kumA:
undetectable		 4y8wC-5kumA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kum ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 12

(Gallus gallus) 		PF01007
(IRK) 		5 VAL A 202
LEU A 209
ILE A 321
ILE A 283
GLY A 282
 None
 1.03A 4y8wC-5kumA:
undetectable		 4y8wC-5kumA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lol GLUTATHIONE
S-TRANSFERASE DHAR2

(Arabidopsis
thaliana) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		5 VAL A 173
ILE A 102
GLY A  99
VAL A 142
LEU A 134
 None
 0.94A 4y8wC-5lolA:
undetectable		 4y8wC-5lolA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nvr TELOMERE LENGTH
REGULATOR PROTEIN
RIF1

(Saccharomyces
cerevisiae) 		PF12231
(Rif1_N) 		5 LEU A 503
ILE A 476
ILE A 429
GLY A 430
LEU A 523
 None
 1.03A 4y8wC-5nvrA:
undetectable		 4y8wC-5nvrA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5txe ATXE2

(Asticcacaulis
excentricus) 		PF00326
(Peptidase_S9) 		6 VAL A 402
LEU A 369
VAL A 464
ILE A 454
VAL A  42
LEU A 394
 None
 1.41A 4y8wC-5txeA:
undetectable		 4y8wC-5txeA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uow N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR1-8A

(Xenopus laevis) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 VAL A 288
ILE A 292
ILE A 119
GLY A 120
LEU A  33
 None
 0.95A 4y8wC-5uowA:
undetectable		 4y8wC-5uowA:
20.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vbu CYTOCHROME P450
21-HYDROXYLASE

(Homo sapiens) 		PF00067
(p450) 		12 VAL A 101
ASP A 107
SER A 109
LEU A 110
VAL A 198
TRP A 202
ILE A 231
ARG A 234
ILE A 291
GLY A 292
VAL A 360
LEU A 364
 3QZ  A 502 (-4.5A)
3QZ  A 502 ( 3.8A)
3QZ  A 502 ( 3.5A)
3QZ  A 502 ( 4.8A)
3QZ  A 502 (-4.6A)
3QZ  A 502 ( 3.9A)
3QZ  A 502 (-4.8A)
3QZ  A 502 (-3.8A)
3QZ  A 502 (-4.3A)
3QZ  A 502 ( 3.2A)
HEM  A 501 ( 4.3A)
3QZ  A 502 (-4.1A)
 0.20A 4y8wC-5vbuA:
64.5		 4y8wC-5vbuA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vc2 SERINE
HYDROXYMETHYLTRANSFE
RASE

(Helicobacter
pylori) 		PF00464
(SHMT) 		5 LEU A 297
VAL A 339
ILE A 337
ILE A 357
GLY A 356
 None
 0.94A 4y8wC-5vc2A:
undetectable		 4y8wC-5vc2A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xkl ESX-3
SECRETION-ASSOCIATED
PROTEIN ESPG3

(Mycobacterium
tuberculosis) 		no annotation 5 LEU A 144
ILE A 104
GLY A 103
VAL A 211
LEU A 148
 None
 1.01A 4y8wC-5xklA:
undetectable		 4y8wC-5xklA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6az1 RIBOSOMAL PROTEIN S5

(Leishmania
donovani) 		no annotation 5 VAL F 151
ILE F 123
GLY F 124
VAL F  79
LEU F  88
 None
 1.00A 4y8wC-6az1F:
undetectable		 4y8wC-6az1F:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d4j PROTEIN PATCHED
HOMOLOG 1

(Homo sapiens) 		no annotation 6 VAL A1081
LEU A 775
VAL A1155
ILE A1085
ILE A1076
GLY A1075
 None
 1.12A 4y8wC-6d4jA:
2.9		 4y8wC-6d4jA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyd PUTATIVE
FAD-DEPENDENT
OXYGENASE ENCM

(Streptomyces
maritimus) 		no annotation 5 VAL A 145
ILE A 161
GLY A 199
VAL A  57
LEU A  94
 None
None
None
None
FAD  A 600 (-4.7A)
 1.02A 4y8wC-6fydA:
undetectable		 4y8wC-6fydA:
10.38