SIMILAR PATTERNS OF AMINO ACIDS FOR 4Y8W_A_STRA604_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ag9 | FLAVODOXIN (Escherichiacoli) |
PF00258(Flavodoxin_1) | 5 | LEU A 73ASP A 107ILE A 108VAL A 83LEU A 85 | None | 1.04A | 4y8wA-1ag9A:0.0 | 4y8wA-1ag9A:16.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b41 | ACETYLCHOLINESTERASE (Homo sapiens) |
PF00135(COesterase) | 5 | VAL A 408TRP A 532ARG A 525GLY A 335VAL A 294 | None | 1.03A | 4y8wA-1b41A:0.0 | 4y8wA-1b41A:21.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bdg | HEXOKINASE (Schistosomamansoni) |
PF00349(Hexokinase_1)PF03727(Hexokinase_2) | 5 | VAL A 226LEU A 228ILE A 390GLY A 387VAL A 297 | None | 1.08A | 4y8wA-1bdgA:0.1 | 4y8wA-1bdgA:21.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cli | PROTEIN(PHOSPHORIBOSYL-AMINOIMIDAZOLESYNTHETASE) (Escherichiacoli) |
PF00586(AIRS)PF02769(AIRS_C) | 5 | VAL A 302ASP A 270ILE A 330GLY A 331VAL A 313 | None | 1.09A | 4y8wA-1cliA:0.0 | 4y8wA-1cliA:23.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ebv | PROSTAGLANDIN H2SYNTHASE (Ovis aries) |
PF00008(EGF)PF03098(An_peroxidase) | 5 | LEU A 230ILE A 337GLY A 338VAL A 344LEU A 534 | NoneNoneNoneNoneOAS A 530 ( 3.3A) | 1.10A | 4y8wA-1ebvA:0.0 | 4y8wA-1ebvA:22.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ejb | LUMAZINE SYNTHASE (Saccharomycescerevisiae) |
PF00885(DMRL_synthase) | 5 | SER A 60VAL A 35LEU A 34ILE A 87GLY A 123 | INJ A 200 (-2.8A)NoneNoneNoneNone | 1.01A | 4y8wA-1ejbA:0.0 | 4y8wA-1ejbA:16.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g67 | THIAMIN PHOSPHATESYNTHASE (Bacillussubtilis) |
PF02581(TMP-TENI) | 5 | ASP A 192VAL A 205ILE A 189GLY A 188VAL A 165 | NoneNoneNoneTZP A2005 (-3.5A)None | 1.06A | 4y8wA-1g67A:0.0 | 4y8wA-1g67A:18.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g8x | MYOSIN II HEAVYCHAIN FUSED TOALPHA-ACTININ 3 (Dictyosteliumdiscoideum) |
PF00063(Myosin_head)PF00435(Spectrin)PF02736(Myosin_N) | 5 | LEU A 425ILE A 351GLY A 350VAL A 384LEU A 389 | None | 1.10A | 4y8wA-1g8xA:0.1 | 4y8wA-1g8xA:19.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i1h | PRECORRIN-8XMETHYLMUTASE (Pseudomonasdenitrificans(nomenrejiciendum)) |
PF02570(CbiC) | 6 | SER A 172VAL A 55ARG A 189ILE A 187GLY A 161LEU A 146 | None | 1.49A | 4y8wA-1i1hA:undetectable | 4y8wA-1i1hA:18.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i6q | LACTOFERRIN (Camelusdromedarius) |
PF00405(Transferrin) | 6 | ASP A 395LEU A 680ARG A 673ILE A 401VAL A 384LEU A 392 | None | 1.38A | 4y8wA-1i6qA:undetectable | 4y8wA-1i6qA:21.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ile | ISOLEUCYL-TRNASYNTHETASE (Thermusthermophilus) |
PF00133(tRNA-synt_1)PF08264(Anticodon_1) | 5 | VAL A 781VAL A 770LEU A 769VAL A 649LEU A 646 | None | 1.03A | 4y8wA-1ileA:undetectable | 4y8wA-1ileA:21.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1inl | SPERMIDINE SYNTHASE (Thermotogamaritima) |
PF01564(Spermine_synth)PF17284(Spermine_synt_N) | 5 | ASP A 63VAL A 126LEU A 125ILE A 48GLY A 41 | None | 1.10A | 4y8wA-1inlA:undetectable | 4y8wA-1inlA:19.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j71 | ASPARTIC PROTEINASE (Candidatropicalis) |
PF00026(Asp) | 5 | VAL A 29ILE A 18GLY A 100VAL A 3LEU A 145 | NoneNoneNoneEOH A 572 ( 4.2A)None | 0.87A | 4y8wA-1j71A:undetectable | 4y8wA-1j71A:18.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kz1 | 6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE (Schizosaccharomycespombe) |
PF00885(DMRL_synthase) | 5 | SER A 62VAL A 36LEU A 35ILE A 84VAL A 124 | None | 1.11A | 4y8wA-1kz1A:undetectable | 4y8wA-1kz1A:18.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1muu | GDP-MANNOSE6-DEHYDROGENASE (Pseudomonasaeruginosa) |
PF00984(UDPG_MGDP_dh)PF03720(UDPG_MGDP_dh_C)PF03721(UDPG_MGDP_dh_N) | 5 | VAL A 29SER A 77VAL A 102ILE A 106LEU A 75 | NoneNoneNAD A1001 (-4.4A)NoneNone | 1.04A | 4y8wA-1muuA:undetectable | 4y8wA-1muuA:23.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nd1 | BAP1 (Bothrops asper) |
PF01421(Reprolysin) | 5 | VAL A 136ARG A 32ILE A 18GLY A 17VAL A 67 | None | 1.04A | 4y8wA-1nd1A:undetectable | 4y8wA-1nd1A:17.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qs0 | 2-OXOISOVALERATEDEHYDROGENASEBETA-SUBUNIT (Pseudomonasputida) |
PF02779(Transket_pyr)PF02780(Transketolase_C) | 5 | ARG B 22ILE B 161GLY B 158VAL B 148LEU B 211 | None | 0.89A | 4y8wA-1qs0B:undetectable | 4y8wA-1qs0B:20.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rf5 | 5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATESYNTHASE (Streptococcuspneumoniae) |
PF00275(EPSP_synthase) | 5 | VAL A 216LEU A 173GLY A 100VAL A 134LEU A 155 | None | 1.08A | 4y8wA-1rf5A:undetectable | 4y8wA-1rf5A:22.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ta3 | XYLANASE INHIBITORPROTEIN I (Triticumaestivum) |
PF00704(Glyco_hydro_18) | 6 | VAL A 33LEU A 120ASP A 62ILE A 63GLY A 60LEU A 51 | None | 1.48A | 4y8wA-1ta3A:undetectable | 4y8wA-1ta3A:20.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v8b | ADENOSYLHOMOCYSTEINASE (Plasmodiumfalciparum) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | VAL A 304ASP A 311ILE A 309GLY A 313VAL A 340 | None | 0.95A | 4y8wA-1v8bA:0.1 | 4y8wA-1v8bA:23.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wsp | AXIN 1 PROTEIN (Rattusnorvegicus) |
PF00778(DIX) | 5 | VAL A 770LEU A 817ILE A 824GLY A 826LEU A 784 | None | 0.82A | 4y8wA-1wspA:undetectable | 4y8wA-1wspA:13.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yii | ANNEXIN A5 (Gallus gallus) |
PF00191(Annexin) | 5 | VAL A 178LEU A 179ILE A 197VAL A 240LEU A 152 | None | 0.92A | 4y8wA-1yiiA:undetectable | 4y8wA-1yiiA:21.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ynz | PIN3P (Saccharomycescerevisiae) |
PF00018(SH3_1) | 5 | ASP A 17ILE A 47GLY A 46VAL A 26LEU A 20 | None | 0.92A | 4y8wA-1ynzA:undetectable | 4y8wA-1ynzA:9.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zap | SECRETED ASPARTICPROTEINASE (Candidaalbicans) |
PF00026(Asp) | 5 | VAL A 29ILE A 18GLY A 100VAL A 3LEU A 144 | None | 0.84A | 4y8wA-1zapA:undetectable | 4y8wA-1zapA:20.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zjy | R-SPECIFIC ALCOHOLDEHYDROGENASE (Lactobacillusbrevis) |
PF13561(adh_short_C2) | 5 | SER A 63LEU A 109ILE A 92GLY A 91VAL A 162 | NAI A1270 (-3.9A)NoneNAI A1270 (-4.6A)NAI A1270 (-3.9A)None | 1.00A | 4y8wA-1zjyA:undetectable | 4y8wA-1zjyA:19.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d3y | URACIL-DNAGLYCOSYLASE (Thermusthermophilus) |
PF03167(UDG) | 5 | ASP A 75SER A 77VAL A 43GLY A 57LEU A 81 | ACT A 222 ( 4.9A)ACT A 222 ( 4.2A)NoneACT A 222 ( 4.7A)None | 0.95A | 4y8wA-2d3yA:undetectable | 4y8wA-2d3yA:19.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h6t | CANDIDAPEPSIN-3 (Candidaalbicans) |
PF00026(Asp) | 5 | VAL A 29ILE A 18GLY A 100VAL A 3LEU A 144 | None | 0.86A | 4y8wA-2h6tA:undetectable | 4y8wA-2h6tA:19.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i6t | UBIQUITIN-CONJUGATING ENZYME E2-LIKEISOFORM A (Homo sapiens) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 5 | VAL A 390ILE A 317GLY A 316VAL A 288LEU A 433 | NoneGOL A 6 (-3.8A)NoneNoneNone | 1.06A | 4y8wA-2i6tA:undetectable | 4y8wA-2i6tA:21.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iv2 | FORMATEDEHYDROGENASE H (Escherichiacoli) |
PF00384(Molybdopterin)PF01568(Molydop_binding)PF04879(Molybdop_Fe4S4) | 5 | VAL X 273LEU X 218ILE X 216VAL X 299LEU X 312 | None | 1.04A | 4y8wA-2iv2X:undetectable | 4y8wA-2iv2X:20.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2kn6 | APOPTOSIS-ASSOCIATEDSPECK-LIKE PROTEINCONTAINING A CARD (Homo sapiens) |
PF00619(CARD)PF02758(PYRIN) | 5 | VAL A 57LEU A 56ARG A 5ILE A 8LEU A 20 | None | 1.07A | 4y8wA-2kn6A:undetectable | 4y8wA-2kn6A:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oxf | URIDINEPHOSPHORYLASE (Salmonellaenterica) |
PF01048(PNP_UDP_1) | 5 | VAL A1141LEU A1140ASP A1133GLY A1214LEU A1021 | None | 1.10A | 4y8wA-2oxfA:undetectable | 4y8wA-2oxfA:21.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qpq | PROTEIN BUG27 (Bordetellapertussis) |
PF03401(TctC) | 5 | VAL A 96VAL A 99ILE A 29GLY A 30LEU A 37 | None | 1.03A | 4y8wA-2qpqA:undetectable | 4y8wA-2qpqA:21.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qzx | CANDIDAPEPSIN-5 (Candidaalbicans) |
PF00026(Asp) | 5 | VAL A 29ILE A 18GLY A 100VAL A 3LEU A 144 | None | 0.85A | 4y8wA-2qzxA:undetectable | 4y8wA-2qzxA:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r4f | 3-HYDROXY-3-METHYLGLUTARYL-COENZYME AREDUCTASE (Homo sapiens) |
PF00368(HMG-CoA_red) | 5 | VAL A 583ASP A 586LEU A 838ILE A 802GLY A 803 | None | 1.03A | 4y8wA-2r4fA:undetectable | 4y8wA-2r4fA:20.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rag | DIPEPTIDASE (Caulobactervibrioides) |
PF01244(Peptidase_M19) | 5 | SER A 228VAL A 401ASP A 226ILE A 247LEU A 263 | None | 1.10A | 4y8wA-2ragA:undetectable | 4y8wA-2ragA:21.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wpg | AMYLOSUCRASE ORALPHA AMYLASE (Xanthomonascampestris) |
PF00128(Alpha-amylase)PF11941(DUF3459) | 5 | VAL A 418ILE A 368GLY A 366VAL A 481LEU A 478 | None | 1.11A | 4y8wA-2wpgA:undetectable | 4y8wA-2wpgA:23.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a9s | D-ARABINOSEISOMERASE (Aeribacilluspallidus) |
PF02952(Fucose_iso_C)PF07881(Fucose_iso_N1)PF07882(Fucose_iso_N2) | 5 | SER A 465LEU A 357ILE A 540GLY A 541LEU A 477 | None | 1.04A | 4y8wA-3a9sA:undetectable | 4y8wA-3a9sA:20.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3abb | CYTOCHROME P450HYDROXYLASE (Streptomycesavermitilis) |
PF00067(p450) | 5 | VAL A 129ILE A 252GLY A 255VAL A 279LEU A 269 | None | 1.01A | 4y8wA-3abbA:34.5 | 4y8wA-3abbA:25.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bg0 | NUCLEOPORIN NUP145 (Saccharomycescerevisiae) |
PF12110(Nup96) | 5 | LEU B 236ILE B 418GLY B 419VAL B 403LEU B 385 | None | 1.01A | 4y8wA-3bg0B:undetectable | 4y8wA-3bg0B:22.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3blx | ISOCITRATEDEHYDROGENASE [NAD]SUBUNIT 2 (Saccharomycescerevisiae) |
PF00180(Iso_dh) | 5 | SER B 302VAL B 350LEU B 354ILE B 43LEU B 306 | None | 1.11A | 4y8wA-3blxB:undetectable | 4y8wA-3blxB:22.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3clm | TRANSALDOLASE (Neisseriagonorrhoeae) |
PF00923(TAL_FSA) | 5 | VAL A 273VAL A 7LEU A 4ILE A 3GLY A 0 | None | 1.05A | 4y8wA-3clmA:undetectable | 4y8wA-3clmA:22.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3es1 | CUPIN 2, CONSERVEDBARREL DOMAINPROTEIN (Novosphingobiumaromaticivorans) |
PF07883(Cupin_2) | 5 | ARG A 81ASP A 100GLY A 102VAL A 121LEU A 111 | None | 1.09A | 4y8wA-3es1A:undetectable | 4y8wA-3es1A:17.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h0g | DNA-DIRECTED RNAPOLYMERASE IISUBUNIT RPB1DNA-DIRECTED RNAPOLYMERASE IISUBUNIT RPB2 (Schizosaccharomycespombe) |
PF00562(RNA_pol_Rpb2_6)PF00623(RNA_pol_Rpb1_2)PF04560(RNA_pol_Rpb2_7)PF04561(RNA_pol_Rpb2_2)PF04563(RNA_pol_Rpb2_1)PF04565(RNA_pol_Rpb2_3)PF04566(RNA_pol_Rpb2_4)PF04567(RNA_pol_Rpb2_5)PF04983(RNA_pol_Rpb1_3)PF04990(RNA_pol_Rpb1_7)PF04992(RNA_pol_Rpb1_6)PF04997(RNA_pol_Rpb1_1)PF04998(RNA_pol_Rpb1_5)PF05000(RNA_pol_Rpb1_4) | 5 | VAL B1016LEU B1015ILE A 672GLY A 673VAL A 749 | None | 0.94A | 4y8wA-3h0gB:undetectable | 4y8wA-3h0gB:16.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hnp | OXIDOREDUCTASE (Bacillus cereus) |
PF01408(GFO_IDH_MocA)PF02894(GFO_IDH_MocA_C) | 6 | LEU A 332ASP A 181ILE A 177GLY A 176VAL A 212LEU A 214 | None | 1.49A | 4y8wA-3hnpA:undetectable | 4y8wA-3hnpA:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i3w | PHOSPHOGLUCOSAMINEMUTASE (Francisellatularensis) |
PF00408(PGM_PMM_IV)PF02878(PGM_PMM_I)PF02879(PGM_PMM_II)PF02880(PGM_PMM_III) | 5 | ASP A 337LEU A 346ILE A 343VAL A 177LEU A 238 | None | 1.09A | 4y8wA-3i3wA:undetectable | 4y8wA-3i3wA:22.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3il3 | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 3 (Haemophilusinfluenzae) |
PF08541(ACP_syn_III_C)PF08545(ACP_syn_III) | 5 | ASP A 150SER A 152VAL A 190LEU A 189GLY A 208 | None | 1.06A | 4y8wA-3il3A:undetectable | 4y8wA-3il3A:20.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kb5 | TRIPARTITEMOTIF-CONTAININGPROTEIN 72 (Homo sapiens) |
PF00622(SPRY)PF13765(PRY) | 5 | SER A 430LEU A 359ASP A 428GLY A 414VAL A 470 | None | 1.01A | 4y8wA-3kb5A:undetectable | 4y8wA-3kb5A:19.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m6c | 60 KDA CHAPERONIN 1 (Mycobacteriumtuberculosis) |
PF00118(Cpn60_TCP1) | 5 | VAL A 293LEU A 290ILE A 191GLY A 192VAL A 274 | None | 1.07A | 4y8wA-3m6cA:undetectable | 4y8wA-3m6cA:19.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mmh | METHIONINE-R-SULFOXIDE REDUCTASE (Neisseriameningitidis) |
PF13185(GAF_2) | 6 | VAL A 26VAL A 42LEU A 43GLY A 53VAL A 119LEU A 121 | MG A 174 ( 4.6A) MG A 170 (-4.0A)NoneNoneNoneNone | 1.49A | 4y8wA-3mmhA:undetectable | 4y8wA-3mmhA:18.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3moz | MYO-INOSITOLHEXAPHOSPHATEPHOSPHOHYDROLASE (Selenomonasruminantium) |
PF14566(PTPlike_phytase) | 5 | VAL A 180TRP A 56ASP A 142ILE A 144GLY A 143 | None | 1.02A | 4y8wA-3mozA:undetectable | 4y8wA-3mozA:20.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ps0 | CRISPR-ASSOCIATEDPROTEIN, CSA2 (Sulfolobussolfataricus) |
PF01905(DevR) | 5 | VAL A 62LEU A 61ILE A 117GLY A 121LEU A 139 | None | 0.96A | 4y8wA-3ps0A:undetectable | 4y8wA-3ps0A:20.45 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3qz1 | STEROID21-HYDROXYLASE (Bos taurus) |
PF00067(p450) | 6 | VAL A 101ASP A 107SER A 109ARG A 232VAL A 358LEU A 362 | NoneNone3QZ A 501 (-3.8A)3QZ A 501 (-3.8A)HEM A 500 (-4.3A)HEM A 500 (-4.7A) | 0.98A | 4y8wA-3qz1A:52.3 | 4y8wA-3qz1A:75.50 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3qz1 | STEROID21-HYDROXYLASE (Bos taurus) |
PF00067(p450) | 7 | VAL A 101SER A 109TRP A 200ARG A 232ASP A 286VAL A 358LEU A 362 | None3QZ A 501 (-3.8A)3QZ A 501 (-4.1A)3QZ A 501 (-3.8A)3QZ A 501 ( 4.7A)HEM A 500 (-4.3A)HEM A 500 (-4.7A) | 0.78A | 4y8wA-3qz1A:52.3 | 4y8wA-3qz1A:75.50 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3qz1 | STEROID21-HYDROXYLASE (Bos taurus) |
PF00067(p450) | 5 | VAL A 101SER A 109TRP A 200ASP A 286GLY A 290 | None3QZ A 501 (-3.8A)3QZ A 501 (-4.1A)3QZ A 501 ( 4.7A)3QZ A 501 (-3.9A) | 1.06A | 4y8wA-3qz1A:52.3 | 4y8wA-3qz1A:75.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3red | HYDROXYNITRILE LYASE (Prunus mume) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 5 | VAL A 470SER A 489VAL A 272LEU A 268LEU A 296 | None | 1.08A | 4y8wA-3redA:undetectable | 4y8wA-3redA:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3viu | PHOSPHORIBOSYLFORMYLGLYCINAMIDINESYNTHASE 2 (Thermusthermophilus) |
PF00586(AIRS)PF02769(AIRS_C) | 5 | ASP A 390TRP A 706GLY A 702VAL A 645LEU A 653 | None | 1.10A | 4y8wA-3viuA:undetectable | 4y8wA-3viuA:21.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vps | NAD-DEPENDENTEPIMERASE/DEHYDRATASE (Streptomyceschartreusis) |
PF01370(Epimerase) | 5 | ASP A 209SER A 236VAL A 245ILE A 291GLY A 290 | None | 1.03A | 4y8wA-3vpsA:undetectable | 4y8wA-3vpsA:21.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wrv | TM-1 PROTEIN (Solanumlycopersicum) |
PF06792(UPF0261) | 5 | VAL A 195VAL A 31ILE A 120GLY A 121LEU A 107 | None | 0.95A | 4y8wA-3wrvA:undetectable | 4y8wA-3wrvA:15.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wry | TM-1 PROTEIN (Solanumlycopersicum) |
PF06792(UPF0261) | 5 | VAL A 195VAL A 31ILE A 120GLY A 121LEU A 107 | None | 1.06A | 4y8wA-3wryA:undetectable | 4y8wA-3wryA:22.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zq4 | RIBONUCLEASE J 1 (Bacillussubtilis) |
PF00753(Lactamase_B)PF07521(RMMBL) | 5 | VAL A 27VAL A 135ILE A 150GLY A 149LEU A 192 | None | 0.99A | 4y8wA-3zq4A:undetectable | 4y8wA-3zq4A:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a0s | OCTENOYL-COAREDUCTASE/CARBOXYLASE (Streptomycescinnabarigriseus) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | SER A 322LEU A 275GLY A 292VAL A 299LEU A 225 | None | 1.07A | 4y8wA-4a0sA:undetectable | 4y8wA-4a0sA:22.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bmv | SHORT-CHAINDEHYDROGENASE (Sphingobiumyanoikuyae) |
PF00106(adh_short) | 5 | VAL A 136LEU A 85ILE A 86VAL A 72LEU A 63 | NoneNoneNoneNoneNAP A 300 (-4.0A) | 0.97A | 4y8wA-4bmvA:undetectable | 4y8wA-4bmvA:21.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cak | INTEGRIN BETA-3 (Homo sapiens) |
PF00362(Integrin_beta)PF07965(Integrin_B_tail)PF07974(EGF_2)PF17205(PSI_integrin) | 5 | VAL B 247VAL B 340LEU B 341GLY B 135LEU B 149 | None | 0.86A | 4y8wA-4cakB:undetectable | 4y8wA-4cakB:20.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4egs | RIBOSE 5-PHOSPHATEISOMERASE RPIB (Caldanaerobactersubterraneus) |
PF01451(LMWPc) | 5 | SER A 36VAL A 52LEU A 55ILE A 63GLY A 19 | SER A 36 ( 0.0A)VAL A 52 ( 0.6A)LEU A 55 ( 0.6A)ILE A 63 ( 0.7A)GLY A 19 ( 0.0A) | 0.98A | 4y8wA-4egsA:undetectable | 4y8wA-4egsA:16.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f7k | LACCASE (unculturedbacterium) |
PF00394(Cu-oxidase)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 5 | VAL A 261ILE A 267GLY A 268VAL A 221LEU A 210 | NoneNoneGOL A 501 ( 4.0A)NoneNone | 1.11A | 4y8wA-4f7kA:undetectable | 4y8wA-4f7kA:22.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hi0 | UREASE ACCESSORYPROTEIN UREG (Helicobacterpylori) |
PF02492(cobW) | 5 | VAL E 33LEU E 96ILE E 18VAL E 187LEU E 184 | None | 1.10A | 4y8wA-4hi0E:undetectable | 4y8wA-4hi0E:17.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kq6 | 6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE ([Candida]glabrata) |
PF00885(DMRL_synthase) | 5 | SER A 61VAL A 36LEU A 35ILE A 88GLY A 124 | None | 0.96A | 4y8wA-4kq6A:undetectable | 4y8wA-4kq6A:14.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kyq | PHOSPHOGLUCANPHOSPHATASE LSF2,CHLOROPLASTIC (Arabidopsisthaliana) |
PF00782(DSPc) | 5 | LEU A 223ILE A 205GLY A 202VAL A 191LEU A 178 | None | 0.93A | 4y8wA-4kyqA:undetectable | 4y8wA-4kyqA:18.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lxf | TREHALOSE SYNTHASE (Mycobacteriumtuberculosis) |
PF00128(Alpha-amylase)PF16657(Malt_amylase_C) | 5 | ASP A 76LEU A 122ILE A 72GLY A 70VAL A 52 | None | 1.11A | 4y8wA-4lxfA:undetectable | 4y8wA-4lxfA:21.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q9a | TAT PATHWAY SIGNALSEQUENCE DOMAINPROTEIN (Parabacteroidesmerdae) |
PF13472(Lipase_GDSL_2) | 5 | VAL A 132ASP A 233ILE A 184GLY A 181VAL A 222 | None | 0.97A | 4y8wA-4q9aA:undetectable | 4y8wA-4q9aA:18.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qb9 | ENHANCEDINTRACELLULARSURVIVAL PROTEIN (Mycolicibacteriumsmegmatis) |
PF13527(Acetyltransf_9)PF13530(SCP2_2) | 5 | VAL A 366VAL A 355LEU A 356ILE A 351LEU A 312 | None | 0.98A | 4y8wA-4qb9A:undetectable | 4y8wA-4qb9A:23.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rf3 | NADPH DEPENDENTR-SPECIFIC ALCOHOLDEHYDROGENASE (Lactobacilluskefiri) |
PF13561(adh_short_C2) | 5 | ASP A 63LEU A 110ILE A 93GLY A 92VAL A 163 | None | 1.08A | 4y8wA-4rf3A:undetectable | 4y8wA-4rf3A:18.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xdt | FAD:PROTEIN FMNTRANSFERASE (Treponemapallidum) |
PF02424(ApbE) | 5 | VAL A 319SER A 274VAL A 331GLY A 215VAL A 232 | NoneACT A 409 ( 4.5A)NoneACT A 409 (-4.3A)EDO A 411 (-3.2A) | 1.10A | 4y8wA-4xdtA:undetectable | 4y8wA-4xdtA:22.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xri | PUTATIVEUNCHARACTERIZEDPROTEIN (Chaetomiumthermophilum) |
PF03810(IBN_N)PF13513(HEAT_EZ) | 5 | VAL A 140LEU A 139ILE A 158GLY A 159LEU A 169 | None | 0.90A | 4y8wA-4xriA:undetectable | 4y8wA-4xriA:20.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yv2 | SPERMIDINE SYNTHASE,PUTATIVE (Trypanosomacruzi) |
PF01564(Spermine_synth)PF17284(Spermine_synt_N) | 5 | VAL A 255SER A 282LEU A 245GLY A 243LEU A 285 | None | 1.01A | 4y8wA-4yv2A:undetectable | 4y8wA-4yv2A:20.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ywn | NADH-FMNOXIDOREDUCTASE (Mycobacteriumavium) |
PF01613(Flavin_Reduct) | 5 | VAL A 53LEU A 137ILE A 75GLY A 74LEU A 38 | None | 1.08A | 4y8wA-4ywnA:undetectable | 4y8wA-4ywnA:16.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z0t | OXIDOREDUCTASE,SHORT-CHAINDEHYDROGENASE/REDUCTASE FAMILY (Brucella ovis) |
PF00106(adh_short) | 5 | VAL A 185VAL A 213ILE A 19GLY A 20VAL A 34 | NoneNone BR A 304 (-4.5A)NoneNone | 1.02A | 4y8wA-4z0tA:undetectable | 4y8wA-4z0tA:21.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z4l | CELLOBIOSE2-EPIMERASE (Caldicellulosiruptorsaccharolyticus) |
PF07221(GlcNAc_2-epim) | 5 | VAL A 189LEU A 190ILE A 212VAL A 271LEU A 262 | None | 0.95A | 4y8wA-4z4lA:undetectable | 4y8wA-4z4lA:20.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5aff | SYMPORTIN 1 (Chaetomiumthermophilum) |
no annotation | 5 | VAL A 422LEU A 417ILE A 452GLY A 316LEU A 323 | None | 1.05A | 4y8wA-5affA:undetectable | 4y8wA-5affA:22.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eaw | DNA REPLICATIONATP-DEPENDENTHELICASE/NUCLEASEDNA2 (Mus musculus) |
PF08696(Dna2)PF13086(AAA_11)PF13087(AAA_12) | 6 | VAL A 663LEU A 662ASP A 763ILE A 761VAL A 822LEU A 824 | None | 1.31A | 4y8wA-5eawA:undetectable | 4y8wA-5eawA:19.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ees | 4-HYDROXY-TETRAHYDRODIPICOLINATEREDUCTASE (Corynebacteriumglutamicum) |
PF01113(DapB_N)PF05173(DapB_C) | 5 | SER A 25VAL A 50ASP A 27ILE A 3GLY A 2 | None | 0.86A | 4y8wA-5eesA:undetectable | 4y8wA-5eesA:17.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fcl | CRISPR-ASSOCIATEDENDONUCLEASE CAS1 (Pectobacteriumatrosepticum) |
PF01867(Cas_Cas1) | 5 | VAL A 244LEU A 245ASP A 308ILE A 311GLY A 312 | None | 1.04A | 4y8wA-5fclA:undetectable | 4y8wA-5fclA:22.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gai | PORTAL PROTEIN (Salmonellavirus P22) |
PF16510(P22_portal) | 5 | VAL A 68LEU A 67ARG A 116ILE A 119VAL A 415 | None | 1.09A | 4y8wA-5gaiA:undetectable | 4y8wA-5gaiA:21.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5im4 | 6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE (Candidaalbicans) |
PF00885(DMRL_synthase) | 5 | SER A 61VAL A 36LEU A 35ILE A 88GLY A 124 | None | 0.98A | 4y8wA-5im4A:undetectable | 4y8wA-5im4A:16.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j5d | 4-HYDROXY-TETRAHYDRODIPICOLINATESYNTHASE (Mycobacteriumtuberculosis) |
PF00701(DHDPS) | 5 | VAL A 244ASP A 196SER A 212VAL A 298LEU A 15 | None | 0.88A | 4y8wA-5j5dA:undetectable | 4y8wA-5j5dA:20.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j7u | MAJOR CAPSID PROTEIN (Faustovirus) |
PF04451(Capsid_NCLDV) | 5 | VAL A 424ILE A 609GLY A 449VAL A 526LEU A 568 | None | 1.02A | 4y8wA-5j7uA:undetectable | 4y8wA-5j7uA:20.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j7u | MAJOR CAPSID PROTEIN (Faustovirus) |
PF04451(Capsid_NCLDV) | 5 | VAL A 424LEU A 608GLY A 449VAL A 526LEU A 568 | None | 0.99A | 4y8wA-5j7uA:undetectable | 4y8wA-5j7uA:20.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lol | GLUTATHIONES-TRANSFERASE DHAR2 (Arabidopsisthaliana) |
PF13410(GST_C_2)PF13417(GST_N_3) | 5 | VAL A 173ILE A 102GLY A 99VAL A 142LEU A 134 | None | 0.92A | 4y8wA-5lolA:undetectable | 4y8wA-5lolA:18.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lon | KLLA0E01827P (Kluyveromyceslactis) |
PF06058(DCP1) | 5 | VAL B 141LEU B 178ILE B 116GLY B 100LEU B 54 | None | 0.95A | 4y8wA-5lonB:undetectable | 4y8wA-5lonB:15.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tur | SERINE/THREONINE-PROTEIN KINASE PIM-1 (Homo sapiens) |
no annotation | 5 | ASP A 234VAL A 151LEU A 182ASP A 170ILE A 173 | None | 1.04A | 4y8wA-5turA:undetectable | 4y8wA-5turA:23.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u30 | CRISPR-ASSOCIATEDENDONUCLEASE C2C1 (Alicyclobacillusacidoterrestris) |
no annotation | 6 | VAL A 434LEU A 423ARG A 432GLY A 21VAL A 500LEU A 12 | None | 1.40A | 4y8wA-5u30A:undetectable | 4y8wA-5u30A:17.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u7w | APYRASE (Trifoliumrepens) |
PF01150(GDA1_CD39) | 5 | LEU A 91ASP A 12GLY A 86VAL A 106LEU A 62 | None | 1.04A | 4y8wA-5u7wA:undetectable | 4y8wA-5u7wA:22.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u7x | NOD FACTOR BINDINGLECTIN-NUCLEOTIDEPHOSPHOHYDROLASE (Vignaunguiculata) |
PF01150(GDA1_CD39) | 5 | LEU F 91ASP F 12GLY F 86VAL F 106LEU F 62 | None MN F 503 ( 4.2A)NoneNoneNone | 1.00A | 4y8wA-5u7xF:undetectable | 4y8wA-5u7xF:20.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u81 | ACID CERAMIDASEISOFORM B (Heterocephalusglaber) |
no annotation | 5 | LEU A 275ILE A 249GLY A 250VAL A 256LEU A 221 | NoneNoneNonePG4 A 418 ( 3.9A)None | 1.05A | 4y8wA-5u81A:undetectable | 4y8wA-5u81A:10.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uve | SUBSTRATE-BINDINGREGION OF ABC-TYPEGLYCINE BETAINETRANSPORT SYSTEM (Brucellaabortus) |
PF04069(OpuAC) | 5 | ASP A 277VAL A 231LEU A 229ILE A 224GLY A 223 | None | 1.11A | 4y8wA-5uveA:undetectable | 4y8wA-5uveA:21.96 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5vbu | CYTOCHROME P45021-HYDROXYLASE (Homo sapiens) |
PF00067(p450) | 12 | VAL A 101ASP A 107SER A 109VAL A 198LEU A 199TRP A 202ARG A 234ASP A 288ILE A 291GLY A 292VAL A 360LEU A 364 | 3QZ A 502 (-4.5A)3QZ A 502 ( 3.8A)3QZ A 502 ( 3.5A)3QZ A 502 (-4.6A)3QZ A 502 ( 4.7A)3QZ A 502 ( 3.9A)3QZ A 502 (-3.8A)3QZ A 502 (-4.0A)3QZ A 502 (-4.3A)3QZ A 502 ( 3.2A)HEM A 501 ( 4.3A)3QZ A 502 (-4.1A) | 0.31A | 4y8wA-5vbuA:63.3 | 4y8wA-5vbuA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yem | CATALASE (Mycothermusthermophilus) |
no annotation | 5 | LEU A 276ASP A 330ILE A 280GLY A 285LEU A 327 | None | 0.96A | 4y8wA-5yemA:undetectable | 4y8wA-5yemA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6az1 | RIBOSOMAL PROTEIN S5 (Leishmaniadonovani) |
no annotation | 5 | VAL F 151ILE F 123GLY F 124VAL F 79LEU F 88 | None | 1.05A | 4y8wA-6az1F:undetectable | 4y8wA-6az1F:10.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6erq | DIMETHYLADENOSINETRANSFERASE 2,MITOCHONDRIAL (Homo sapiens) |
no annotation | 5 | SER F 169LEU F 207ARG F 157ASP F 155VAL F 191 | None | 1.10A | 4y8wA-6erqF:undetectable | 4y8wA-6erqF:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fv4 | N-ACETYLGLUCOSAMINE-6-PHOSPHATEDEACETYLASE (Mycolicibacteriumsmegmatis) |
no annotation | 5 | VAL A 104LEU A 107ILE A 119GLY A 118LEU A 57 | None | 1.07A | 4y8wA-6fv4A:undetectable | 4y8wA-6fv4A:10.87 |