SIMILAR PATTERNS OF AMINO ACIDS FOR 4Y1D_D_DVAD5

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bvu PROTEIN (GLUTAMATE
DEHYDROGENASE)

(Thermococcus
litoralis) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		3 GLU A 285
LYS A 309
ASN A 304
 None
 1.09A 4y1dA-1bvuA:
0.0
4y1dD-1bvuA:
undetectable		 4y1dA-1bvuA:
19.57
4y1dD-1bvuA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE

(Shewanella
oneidensis) 		PF00890
(FAD_binding_2)
PF14537
(Cytochrom_c3_2) 		3 GLU A 296
LYS A 294
ASN A 274
 None
 0.99A 4y1dA-1d4eA:
0.0
4y1dD-1d4eA:
undetectable		 4y1dA-1d4eA:
17.09
4y1dD-1d4eA:
4.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpl RP2 LIPASE

(Cavia porcellus) 		PF00151
(Lipase)
PF01477
(PLAT) 		3 GLU A 278
LYS A 306
ASN A 276
 None
 1.08A 4y1dA-1gplA:
0.0
4y1dD-1gplA:
undetectable		 4y1dA-1gplA:
16.86
4y1dD-1gplA:
1.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m6j TRIOSEPHOSPHATE
ISOMERASE

(Entamoeba
histolytica) 		PF00121
(TIM) 		3 GLU A 203
LYS A 199
ASN A 204
 None
 1.10A 4y1dA-1m6jA:
undetectable
4y1dD-1m6jA:
undetectable		 4y1dA-1m6jA:
22.05
4y1dD-1m6jA:
1.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nar NARBONIN

(Vicia
narbonensis) 		PF00704
(Glyco_hydro_18) 		3 GLU A 107
LYS A 106
ASN A 104
 None
 1.08A 4y1dA-1narA:
0.0
4y1dD-1narA:
undetectable		 4y1dA-1narA:
19.59
4y1dD-1narA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ovw ENDOGLUCANASE I

(Fusarium
oxysporum) 		PF00840
(Glyco_hydro_7) 		3 GLU A  14
LYS A  12
ASN A  90
 None
 0.86A 4y1dA-1ovwA:
0.0
4y1dD-1ovwA:
undetectable		 4y1dA-1ovwA:
16.17
4y1dD-1ovwA:
2.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPE-SUBUNIT))

(Sulfolobus
solfataricus) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		3 GLU A 125
LYS A 127
ASN A 124
 None
 1.06A 4y1dA-1qdlA:
0.0
4y1dD-1qdlA:
undetectable		 4y1dA-1qdlA:
17.19
4y1dD-1qdlA:
1.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qpg 3-PHOSPHOGLYCERATE
KINASE

(Saccharomyces
cerevisiae) 		PF00162
(PGK) 		3 GLU A  82
LYS A  32
ASN A  36
 None
 0.95A 4y1dA-1qpgA:
0.0
4y1dD-1qpgA:
undetectable		 4y1dA-1qpgA:
16.83
4y1dD-1qpgA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qvb BETA-GLYCOSIDASE

(Thermosphaera
aggregans) 		PF00232
(Glyco_hydro_1) 		3 GLU A 214
LYS A 286
ASN A 210
 None
 1.00A 4y1dA-1qvbA:
0.0
4y1dD-1qvbA:
undetectable		 4y1dA-1qvbA:
17.05
4y1dD-1qvbA:
2.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qxy METHIONYL
AMINOPEPTIDASE

(Staphylococcus
aureus) 		PF00557
(Peptidase_M24) 		3 GLU A  72
LYS A 226
ASN A  71
 None
 1.06A 4y1dA-1qxyA:
undetectable
4y1dD-1qxyA:
undetectable		 4y1dA-1qxyA:
21.32
4y1dD-1qxyA:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rwl SERINE/THREONINE-PRO
TEIN KINASE PKND

(Mycobacterium
tuberculosis) 		PF01436
(NHL) 		3 GLU A 177
LYS A 175
ASN A 182
 None
 0.93A 4y1dA-1rwlA:
undetectable
4y1dD-1rwlA:
undetectable		 4y1dA-1rwlA:
21.89
4y1dD-1rwlA:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s0p ADENYLYL
CYCLASE-ASSOCIATED
PROTEIN

(Dictyostelium
discoideum) 		PF01213
(CAP_N) 		3 GLU A  82
LYS A  71
ASN A  79
 None
 0.87A 4y1dA-1s0pA:
0.9
4y1dD-1s0pA:
undetectable		 4y1dA-1s0pA:
19.35
4y1dD-1s0pA:
3.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum) 		PF01593
(Amino_oxidase) 		3 GLU A 424
LYS A 347
ASN A 345
 None
 0.99A 4y1dA-1sezA:
undetectable
4y1dD-1sezA:
undetectable		 4y1dA-1sezA:
15.08
4y1dD-1sezA:
1.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6x RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE

(Thermotoga
maritima) 		PF01687
(Flavokinase)
PF06574
(FAD_syn) 		3 GLU A 231
LYS A 229
ASN A 215
 None
 0.96A 4y1dA-1t6xA:
undetectable
4y1dD-1t6xA:
undetectable		 4y1dA-1t6xA:
21.21
4y1dD-1t6xA:
2.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdt TETRAHYDRODIPICOLINA
TE-N-SUCCINYLTRANSFE
RASE

(Mycobacterium
bovis) 		PF00132
(Hexapep)
PF14602
(Hexapep_2)
PF14805
(THDPS_N_2) 		3 GLU A 136
LYS A 154
ASN A 120
 None
 0.87A 4y1dA-1tdtA:
undetectable
4y1dD-1tdtA:
undetectable		 4y1dA-1tdtA:
25.55
4y1dD-1tdtA:
2.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tll NITRIC-OXIDE
SYNTHASE, BRAIN

(Rattus
norvegicus) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		3 GLU A 789
LYS A 820
ASN A 817
 None
 1.01A 4y1dA-1tllA:
undetectable
4y1dD-1tllA:
undetectable		 4y1dA-1tllA:
13.05
4y1dD-1tllA:
3.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpr LUCIFERASE

(Lingulodinium
polyedra) 		PF10284
(Luciferase_3H)
PF10285
(Luciferase_cat) 		3 GLU A1133
LYS A 992
ASN A1112
 None
 1.07A 4y1dA-1vprA:
undetectable
4y1dD-1vprA:
undetectable		 4y1dA-1vprA:
18.16
4y1dD-1vprA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ykw RUBISCO-LIKE PROTEIN

(Chlorobaculum
tepidum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		3 GLU A 231
LYS A 233
ASN A 160
 None
 0.74A 4y1dA-1ykwA:
undetectable
4y1dD-1ykwA:
undetectable		 4y1dA-1ykwA:
18.29
4y1dD-1ykwA:
1.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlr COAGULATION FACTOR
XI

(Homo sapiens) 		PF00089
(Trypsin) 		3 GLU A 202
LYS A 202
ASN A 202
 None
 0.93A 4y1dA-1zlrA:
undetectable
4y1dD-1zlrA:
undetectable		 4y1dA-1zlrA:
24.39
4y1dD-1zlrA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c5u RNA LIGASE

(Escherichia
virus T4) 		PF09511
(RNA_lig_T4_1) 		3 GLU A  81
LYS A 275
ASN A  78
 None
 0.96A 4y1dA-2c5uA:
undetectable
4y1dD-2c5uA:
undetectable		 4y1dA-2c5uA:
17.55
4y1dD-2c5uA:
2.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ckh SMALL
UBIQUITIN-RELATED
MODIFIER 2

(Homo sapiens) 		PF11976
(Rad60-SLD) 		3 GLU B  80
LYS B  20
ASN B  18
 None
 1.01A 4y1dA-2ckhB:
1.7
4y1dD-2ckhB:
undetectable		 4y1dA-2ckhB:
18.56
4y1dD-2ckhB:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csn CASEIN KINASE-1

(Schizosaccharomyces
pombe) 		PF00069
(Pkinase) 		3 GLU A  43
LYS A  41
ASN A  81
 None
 1.05A 4y1dA-2csnA:
undetectable
4y1dD-2csnA:
undetectable		 4y1dA-2csnA:
21.36
4y1dD-2csnA:
5.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2edt OBSCURIN

(Homo sapiens) 		PF07679
(I-set) 		3 GLU A  45
LYS A  42
ASN A  46
 None
 1.00A 4y1dA-2edtA:
undetectable
4y1dD-2edtA:
undetectable		 4y1dA-2edtA:
23.84
4y1dD-2edtA:
30.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fb0 CONSERVED
HYPOTHETICAL PROTEIN

(Bacteroides
thetaiotaomicron) 		PF03992
(ABM) 		3 GLU A  87
LYS A  85
ASN A   5
 GOL  A 804 (-4.6A)
None
None
 1.09A 4y1dA-2fb0A:
undetectable
4y1dD-2fb0A:
undetectable		 4y1dA-2fb0A:
19.88
4y1dD-2fb0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5l COLD SHOCK PROTEIN
CSPB

(Bacillus
subtilis) 		PF00313
(CSD) 		3 GLU X  50
LYS X   1
ASN X  62
 None
 1.06A 4y1dA-2i5lX:
undetectable
4y1dD-2i5lX:
undetectable		 4y1dA-2i5lX:
20.62
4y1dD-2i5lX:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ijx DNA POLYMERASE
SLIDING CLAMP A

(Sulfolobus
solfataricus) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		3 GLU A 167
LYS A 165
ASN A 152
 None
 1.03A 4y1dA-2ijxA:
undetectable
4y1dD-2ijxA:
undetectable		 4y1dA-2ijxA:
19.68
4y1dD-2ijxA:
3.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2io1 SMALL
UBIQUITIN-RELATED
MODIFIER 3 PRECURSOR

(Homo sapiens) 		PF11976
(Rad60-SLD) 		3 GLU B  80
LYS B  20
ASN B  18
 None
 0.67A 4y1dA-2io1B:
undetectable
4y1dD-2io1B:
undetectable		 4y1dA-2io1B:
21.97
4y1dD-2io1B:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ioj HYPOTHETICAL PROTEIN
AF_1212

(Archaeoglobus
fulgidus) 		PF07085
(DRTGG) 		3 GLU A 231
LYS A 206
ASN A 252
 None
 0.97A 4y1dA-2iojA:
undetectable
4y1dD-2iojA:
undetectable		 4y1dA-2iojA:
19.66
4y1dD-2iojA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipx RRNA
2'-O-METHYLTRANSFERA
SE FIBRILLARIN

(Homo sapiens) 		PF01269
(Fibrillarin) 		3 GLU A 134
LYS A 132
ASN A 111
 None
 0.97A 4y1dA-2ipxA:
undetectable
4y1dD-2ipxA:
undetectable		 4y1dA-2ipxA:
21.88
4y1dD-2ipxA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n32 NISIN IMMUNITY
PROTEIN

(Lactococcus
lactis) 		no annotation 3 GLU A  76
LYS A  42
ASN A  39
 None
 1.02A 4y1dA-2n32A:
undetectable
4y1dD-2n32A:
undetectable		 4y1dA-2n32A:
18.34
4y1dD-2n32A:
50.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal disease
virus) 		PF04197
(Birna_RdRp) 		3 GLU A 418
LYS A 529
ASN A 527
 None
 1.03A 4y1dA-2pggA:
undetectable
4y1dD-2pggA:
undetectable		 4y1dA-2pggA:
13.40
4y1dD-2pggA:
1.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qae DIHYDROLIPOYL
DEHYDROGENASE

(Trypanosoma
cruzi) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 GLU A 114
LYS A  33
ASN A 126
 None
FAD  A 480 (-4.6A)
None
 0.90A 4y1dA-2qaeA:
undetectable
4y1dD-2qaeA:
undetectable		 4y1dA-2qaeA:
16.85
4y1dD-2qaeA:
1.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqh COMPLEMENT COMPONENT
C8 ALPHA CHAIN

(Homo sapiens) 		PF01823
(MACPF) 		3 GLU A 248
LYS A 251
ASN A 247
 None
 1.09A 4y1dA-2qqhA:
undetectable
4y1dD-2qqhA:
undetectable		 4y1dA-2qqhA:
19.52
4y1dD-2qqhA:
2.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qu7 PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Staphylococcus
saprophyticus) 		PF13407
(Peripla_BP_4) 		3 GLU A 163
LYS A 202
ASN A 198
 None
 0.85A 4y1dA-2qu7A:
undetectable
4y1dD-2qu7A:
undetectable		 4y1dA-2qu7A:
21.09
4y1dD-2qu7A:
3.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r17 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 35

(Homo sapiens) 		PF03635
(Vps35) 		3 GLU C 597
LYS C 555
ASN C 598
 None
 0.78A 4y1dA-2r17C:
undetectable
4y1dD-2r17C:
undetectable		 4y1dA-2r17C:
18.92
4y1dD-2r17C:
4.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vat ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE

(Acremonium
chrysogenum) 		PF00561
(Abhydrolase_1) 		3 GLU A 360
LYS A 226
ASN A 359
 None
COA  A1383 (-2.8A)
None
 1.11A 4y1dA-2vatA:
undetectable
4y1dD-2vatA:
undetectable		 4y1dA-2vatA:
18.49
4y1dD-2vatA:
5.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w6d DYNAMIN FAMILY
PROTEIN

(Nostoc
punctiforme) 		PF00350
(Dynamin_N) 		3 GLU A 464
LYS A 545
ASN A 550
 None
 1.01A 4y1dA-2w6dA:
undetectable
4y1dD-2w6dA:
undetectable		 4y1dA-2w6dA:
13.39
4y1dD-2w6dA:
0.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wd6 AGGLUTININ RECEPTOR

(Streptococcus
gordonii) 		PF06696
(Strep_SA_rep)
PF08363
(GbpC) 		3 GLU A 591
LYS A 559
ASN A 622
 None
 0.92A 4y1dA-2wd6A:
undetectable
4y1dD-2wd6A:
undetectable		 4y1dA-2wd6A:
17.54
4y1dD-2wd6A:
2.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x2g TRIOSEPHOSPHATE
ISOMERASE,
GLYCOSOMAL

(Trypanosoma
brucei) 		PF00121
(TIM) 		3 GLU A 107
LYS A 152
ASN A 106
 None
 0.94A 4y1dA-2x2gA:
undetectable
4y1dD-2x2gA:
undetectable		 4y1dA-2x2gA:
24.58
4y1dD-2x2gA:
5.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x6k PHOSPHOTIDYLINOSITOL
3 KINASE 59F

(Drosophila
melanogaster) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka) 		3 GLU A 906
LYS A 902
ASN A 907
 None
 1.11A 4y1dA-2x6kA:
undetectable
4y1dD-2x6kA:
undetectable		 4y1dA-2x6kA:
13.90
4y1dD-2x6kA:
4.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yia RNA-DIRECTED RNA
POLYMERASE

(Infectious
pancreatic
necrosis virus) 		PF04197
(Birna_RdRp) 		3 GLU A 404
LYS A 516
ASN A 514
 None
None
K  A1002 (-3.5A)
 0.81A 4y1dA-2yiaA:
undetectable
4y1dD-2yiaA:
undetectable		 4y1dA-2yiaA:
13.42
4y1dD-2yiaA:
1.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yib RNA-DIRECTED RNA
POLYMERASE

(Infectious
pancreatic
necrosis virus) 		PF04197
(Birna_RdRp) 		3 GLU D 404
LYS D 516
ASN D 514
 None
 0.80A 4y1dA-2yibD:
undetectable
4y1dD-2yibD:
undetectable		 4y1dA-2yibD:
13.81
4y1dD-2yibD:
0.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zqm PREFOLDIN BETA
SUBUNIT 1

(Thermococcus
sp. JCM 11816) 		PF01920
(Prefoldin_2) 		3 GLU A  90
LYS A  29
ASN A  87
 None
 0.99A 4y1dA-2zqmA:
undetectable
4y1dD-2zqmA:
undetectable		 4y1dA-2zqmA:
23.56
4y1dD-2zqmA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aay PUTATIVE THIOSULFATE
SULFURTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00581
(Rhodanese) 		3 GLU A  77
LYS A 105
ASN A  76
 None
 0.90A 4y1dA-3aayA:
undetectable
4y1dD-3aayA:
undetectable		 4y1dA-3aayA:
21.28
4y1dD-3aayA:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d45 POLY(A)-SPECIFIC
RIBONUCLEASE PARN

(Mus musculus) 		PF01424
(R3H)
PF04857
(CAF1)
PF08675
(RNA_bind) 		3 GLU A   2
LYS A 125
ASN A  89
 None
 0.88A 4y1dA-3d45A:
undetectable
4y1dD-3d45A:
undetectable		 4y1dA-3d45A:
17.19
4y1dD-3d45A:
3.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dcm UNCHARACTERIZED
PROTEIN TM_1570

(Thermotoga
maritima) 		PF09936
(Methyltrn_RNA_4) 		3 GLU X   3
LYS X  44
ASN X  42
 None
 0.97A 4y1dA-3dcmX:
undetectable
4y1dD-3dcmX:
undetectable		 4y1dA-3dcmX:
18.75
4y1dD-3dcmX:
5.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3x BIPA

(Vibrio
parahaemolyticus) 		PF00679
(EFG_C) 		3 GLU A 103
LYS A  49
ASN A  38
 MLZ  A  45 ( 3.8A)
MLY  A  48 ( 3.3A)
None
 0.92A 4y1dA-3e3xA:
undetectable
4y1dD-3e3xA:
undetectable		 4y1dA-3e3xA:
20.67
4y1dD-3e3xA:
1.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ig2 PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Bacteroides
fragilis) 		no annotation 3 GLU A 645
LYS A 641
ASN A 646
 None
 0.99A 4y1dA-3ig2A:
undetectable
4y1dD-3ig2A:
undetectable		 4y1dA-3ig2A:
21.00
4y1dD-3ig2A:
2.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8k ALPHA-AMYLASE, SUSG

(Bacteroides
thetaiotaomicron) 		PF00128
(Alpha-amylase) 		3 GLU A 617
LYS A 472
ASN A 616
 None
 1.03A 4y1dA-3k8kA:
2.9
4y1dD-3k8kA:
undetectable		 4y1dA-3k8kA:
13.69
4y1dD-3k8kA:
1.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwy CHROMO
DOMAIN-CONTAINING
PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00176
(SNF2_N)
PF00271
(Helicase_C)
PF00385
(Chromo) 		3 GLU W 318
LYS W 461
ASN W 315
 None
 1.10A 4y1dA-3mwyW:
undetectable
4y1dD-3mwyW:
undetectable		 4y1dA-3mwyW:
11.50
4y1dD-3mwyW:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nng UNCHARACTERIZED
PROTEIN

(Bacteroides
fragilis) 		PF00754
(F5_F8_type_C) 		3 GLU A 278
LYS A 313
ASN A 311
 None
 1.06A 4y1dA-3nngA:
undetectable
4y1dD-3nngA:
undetectable		 4y1dA-3nngA:
19.08
4y1dD-3nngA:
3.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3of7 REGULATOR OF
CHROMOSOME
CONDENSATION

(Saccharomyces
cerevisiae) 		PF00415
(RCC1)
PF13540
(RCC1_2) 		3 GLU A 102
LYS A  85
ASN A 104
 None
 0.99A 4y1dA-3of7A:
undetectable
4y1dD-3of7A:
undetectable		 4y1dA-3of7A:
16.45
4y1dD-3of7A:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rle GOLGI
REASSEMBLY-STACKING
PROTEIN 2

(Homo sapiens) 		PF04495
(GRASP55_65) 		3 GLU A 157
LYS A 159
ASN A 181
 None
 0.93A 4y1dA-3rleA:
undetectable
4y1dD-3rleA:
undetectable		 4y1dA-3rleA:
24.77
4y1dD-3rleA:
31.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sbu HYPOTHETICAL
NTF2-LIKE PROTEIN

(Bacteroides
fragilis) 		PF14254
(DUF4348) 		3 GLU A 138
LYS A 150
ASN A 238
 GOL  A 285 ( 4.3A)
MLY  A 149 ( 3.3A)
MLY  A 149 ( 4.2A)
 1.10A 4y1dA-3sbuA:
undetectable
4y1dD-3sbuA:
undetectable		 4y1dA-3sbuA:
18.11
4y1dD-3sbuA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tk8 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E

(Burkholderia
pseudomallei) 		PF00132
(Hexapep)
PF14602
(Hexapep_2)
PF14805
(THDPS_N_2) 		3 GLU A 175
LYS A 193
ASN A 159
 None
EDO  A 320 (-3.3A)
None
 0.90A 4y1dA-3tk8A:
undetectable
4y1dD-3tk8A:
undetectable		 4y1dA-3tk8A:
20.25
4y1dD-3tk8A:
4.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u2h S-LAYER PROTEIN
MA0829

(Methanosarcina
acetivorans) 		PF07752
(S-layer) 		3 GLU A 468
LYS A 390
ASN A 384
 None
 0.91A 4y1dA-3u2hA:
undetectable
4y1dD-3u2hA:
undetectable		 4y1dA-3u2hA:
19.58
4y1dD-3u2hA:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubr CYTOCHROME C-552

(Shewanella
oneidensis) 		PF02335
(Cytochrom_C552) 		3 GLU A  40
LYS A  43
ASN A  39
 None
 0.61A 4y1dA-3ubrA:
undetectable
4y1dD-3ubrA:
undetectable		 4y1dA-3ubrA:
16.79
4y1dD-3ubrA:
2.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbx PUTATIVE
2,5-DIKETO-D-GLUCONI
C ACID REDUCTASE

(Gluconobacter
oxydans) 		PF00248
(Aldo_ket_red) 		3 GLU A 243
LYS A 239
ASN A 244
 None
 1.10A 4y1dA-3wbxA:
undetectable
4y1dD-3wbxA:
undetectable		 4y1dA-3wbxA:
23.18
4y1dD-3wbxA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3t DNA MISMATCH REPAIR
PROTEIN HSM3

(Saccharomyces
cerevisiae) 		no annotation 3 GLU A 247
LYS A 253
ASN A 250
 None
 0.89A 4y1dA-4a3tA:
undetectable
4y1dD-4a3tA:
undetectable		 4y1dA-4a3tA:
16.49
4y1dD-4a3tA:
4.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4z ANTIVIRAL HELICASE
SKI2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		3 GLU A 836
LYS A 827
ASN A 833
 None
 1.10A 4y1dA-4a4zA:
undetectable
4y1dD-4a4zA:
undetectable		 4y1dA-4a4zA:
11.32
4y1dD-4a4zA:
0.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ah6 ASPARTATE--TRNA
LIGASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		3 GLU A 158
LYS A 164
ASN A 161
 None
 1.09A 4y1dA-4ah6A:
undetectable
4y1dD-4ah6A:
undetectable		 4y1dA-4ah6A:
13.75
4y1dD-4ah6A:
2.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cp2 EPITHELIAL ADHESIN 9

([Candida]
glabrata) 		PF10528
(GLEYA) 		3 GLU A 210
LYS A 206
ASN A 220
 None
 1.06A 4y1dA-4cp2A:
undetectable
4y1dD-4cp2A:
undetectable		 4y1dA-4cp2A:
20.69
4y1dD-4cp2A:
3.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4w DNA POLYMERASE IV

(Sulfolobus
acidocaldarius;
Sulfolobus
solfataricus) 		PF00817
(IMS)
PF11798
(IMS_HHH) 		3 GLU A 178
LYS A 202
ASN A 177
 None
 1.06A 4y1dA-4f4wA:
undetectable
4y1dD-4f4wA:
undetectable		 4y1dA-4f4wA:
18.33
4y1dD-4f4wA:
1.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fhn NUCLEOPORIN NUP120

(Schizosaccharomyces
pombe) 		PF11715
(Nup160) 		3 GLU B 270
LYS B 322
ASN B 324
 None
 0.98A 4y1dA-4fhnB:
undetectable
4y1dD-4fhnB:
undetectable		 4y1dA-4fhnB:
8.83
4y1dD-4fhnB:
2.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gbs PUTATIVE LIPOPROTEIN

(Bacteroides
fragilis) 		PF14064
(HmuY) 		3 GLU A  36
LYS A  40
ASN A 205
 None
MLY  A  39 ( 3.3A)
None
 1.10A 4y1dA-4gbsA:
undetectable
4y1dD-4gbsA:
undetectable		 4y1dA-4gbsA:
21.43
4y1dD-4gbsA:
50.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ife GENE 2 PROTEIN

(Shigella virus
Sf6) 		PF04466
(Terminase_3)
PF17288
(Terminase_3C) 		3 GLU A 121
LYS A 149
ASN A 147
 None
None
ATP  A 800 (-3.0A)
 0.99A 4y1dA-4ifeA:
2.2
4y1dD-4ifeA:
undetectable		 4y1dA-4ifeA:
15.71
4y1dD-4ifeA:
4.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iqe CARBOXYVINYL-CARBOXY
PHOSPHONATE
PHOSPHORYLMUTASE

(Bacillus
anthracis) 		PF13714
(PEP_mutase) 		3 GLU A 192
LYS A 220
ASN A 214
 None
 0.93A 4y1dA-4iqeA:
undetectable
4y1dD-4iqeA:
undetectable		 4y1dA-4iqeA:
20.33
4y1dD-4iqeA:
2.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iy9 30K PROTEIN 1

(Bombyx mori) 		PF03260
(Lipoprotein_11) 		3 GLU A  11
LYS A  48
ASN A  44
 None
 0.99A 4y1dA-4iy9A:
undetectable
4y1dD-4iy9A:
undetectable		 4y1dA-4iy9A:
19.59
4y1dD-4iy9A:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jer HEMOPHORE HASA

(Yersinia pestis) 		PF06438
(HasA) 		3 GLU A  65
LYS A  94
ASN A  63
 None
 1.02A 4y1dA-4jerA:
undetectable
4y1dD-4jerA:
undetectable		 4y1dA-4jerA:
21.26
4y1dD-4jerA:
3.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jru THAUMATIN-LIKE
PROTEIN

(Vitis vinifera) 		PF00314
(Thaumatin) 		3 GLU A  85
LYS A  83
ASN A  73
 None
 0.95A 4y1dA-4jruA:
undetectable
4y1dD-4jruA:
undetectable		 4y1dA-4jruA:
22.48
4y1dD-4jruA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n11 GLUTAREDOXIN

(Plasmodium
falciparum) 		PF00462
(Glutaredoxin) 		3 GLU A  17
LYS A  82
ASN A  13
 MPD  A 202 (-3.8A)
None
MPD  A 202 (-4.1A)
 0.99A 4y1dA-4n11A:
undetectable
4y1dD-4n11A:
undetectable		 4y1dA-4n11A:
20.71
4y1dD-4n11A:
50.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nqf NUCLEOTIDYLTRANSFERA
SE

(Agrobacterium
fabrum) 		PF05168
(HEPN) 		3 GLU A 253
LYS A 257
ASN A 252
 None
 1.00A 4y1dA-4nqfA:
undetectable
4y1dD-4nqfA:
undetectable		 4y1dA-4nqfA:
18.71
4y1dD-4nqfA:
5.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ohn ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF00497
(SBP_bac_3) 		3 GLU A 175
LYS A 168
ASN A 173
 None
 1.09A 4y1dA-4ohnA:
undetectable
4y1dD-4ohnA:
undetectable		 4y1dA-4ohnA:
22.27
4y1dD-4ohnA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qyj ALDEHYDE
DEHYDROGENASE

(Pseudomonas
putida) 		PF00171
(Aldedh) 		3 GLU A 100
LYS A 106
ASN A 103
 None
 1.03A 4y1dA-4qyjA:
undetectable
4y1dD-4qyjA:
undetectable		 4y1dA-4qyjA:
16.31
4y1dD-4qyjA:
2.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r58 LEUCINE RICH REPEAT
PROTEIN

(synthetic
construct) 		PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6) 		3 GLU A 198
LYS A 220
ASN A 218
 None
 1.01A 4y1dA-4r58A:
undetectable
4y1dD-4r58A:
undetectable		 4y1dA-4r58A:
19.56
4y1dD-4r58A:
1.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5abm RETINAL
DEHYDROGENASE 1

(Ovis aries) 		PF00171
(Aldedh) 		3 GLU A 106
LYS A 112
ASN A 109
 None
 1.08A 4y1dA-5abmA:
undetectable
4y1dD-5abmA:
undetectable		 4y1dA-5abmA:
16.00
4y1dD-5abmA:
1.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2i ALR1585 PROTEIN

(Nostoc sp. PCC
7120) 		PF04261
(Dyp_perox) 		3 GLU A 261
LYS A 259
ASN A 450
 None
GOL  A 502 (-2.9A)
None
 1.11A 4y1dA-5c2iA:
undetectable
4y1dD-5c2iA:
undetectable		 4y1dA-5c2iA:
15.60
4y1dD-5c2iA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ca5 NONO-1

(Caenorhabditis
elegans) 		PF00076
(RRM_1)
PF08075
(NOPS) 		3 GLU A 203
LYS A 106
ASN A 202
 None
 0.79A 4y1dA-5ca5A:
undetectable
4y1dD-5ca5A:
undetectable		 4y1dA-5ca5A:
20.85
4y1dD-5ca5A:
4.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e2g BETA-LACTAMASE

(Burkholderia
cenocepacia) 		PF00144
(Beta-lactamase) 		3 GLU A 342
LYS A 346
ASN A 282
 None
 0.95A 4y1dA-5e2gA:
undetectable
4y1dD-5e2gA:
undetectable		 4y1dA-5e2gA:
19.71
4y1dD-5e2gA:
3.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyf GLUTAMATE ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Enterococcus
faecium) 		PF00497
(SBP_bac_3) 		3 GLU A 180
LYS A 159
ASN A 181
 None
 1.00A 4y1dA-5eyfA:
undetectable
4y1dD-5eyfA:
undetectable		 4y1dA-5eyfA:
21.83
4y1dD-5eyfA:
2.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f56 SINGLE-STRANDED-DNA-
SPECIFIC EXONUCLEASE

(Deinococcus
radiodurans) 		PF01368
(DHH)
PF02272
(DHHA1) 		3 GLU A 143
LYS A 145
ASN A 140
 None
 1.07A 4y1dA-5f56A:
undetectable
4y1dD-5f56A:
undetectable		 4y1dA-5f56A:
12.29
4y1dD-5f56A:
2.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fre EXO-ALPHA-SIALIDASE

(Clostridium
perfringens) 		PF02973
(Sialidase) 		3 GLU A  13
LYS A 163
ASN A 165
 None
 0.87A 4y1dA-5freA:
undetectable
4y1dD-5freA:
undetectable		 4y1dA-5freA:
21.86
4y1dD-5freA:
4.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gjw VOLTAGE-DEPENDENT
CALCIUM CHANNEL
SUBUNIT
ALPHA-2/DELTA-1

(Oryctolagus
cuniculus) 		PF00092
(VWA)
PF08399
(VWA_N)
PF08473
(VGCC_alpha2) 		3 GLU F 753
LYS F 749
ASN F 754
 None
 1.03A 4y1dA-5gjwF:
undetectable
4y1dD-5gjwF:
undetectable		 4y1dA-5gjwF:
9.58
4y1dD-5gjwF:
0.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k59 UNCHARACTERIZED
LEUKOCIDIN-LIKE
PROTEIN 2

(Staphylococcus
aureus) 		no annotation 3 GLU D 110
LYS D 288
ASN D 269
 None
 1.01A 4y1dA-5k59D:
undetectable
4y1dD-5k59D:
undetectable		 4y1dA-5k59D:
17.70
4y1dD-5k59D:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5p PRE-MRNA-SPLICING
HELICASE BRR2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		3 GLU A 764
LYS A 760
ASN A 765
 None
 1.09A 4y1dA-5m5pA:
undetectable
4y1dD-5m5pA:
undetectable		 4y1dA-5m5pA:
7.27
4y1dD-5m5pA:
0.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mju EXCITATORY AMINO
ACID TRANSPORTER
1,NEUTRAL AMINO ACID
TRANSPORTER
B(0),EXCITATORY
AMINO ACID
TRANSPORTER 1

(Homo sapiens) 		PF00375
(SDF) 		3 GLU A 256
LYS A 260
ASN A 255
 None
 1.03A 4y1dA-5mjuA:
undetectable
4y1dD-5mjuA:
undetectable		 4y1dA-5mjuA:
14.72
4y1dD-5mjuA:
1.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0s GLUCOSYLCERAMIDASE

(Thermoanaerobacterium
xylanolyticum) 		PF04685
(DUF608)
PF12215
(Glyco_hydr_116N)
PF17168
(DUF5127) 		3 GLU A 118
LYS A 116
ASN A 206
 None
 0.90A 4y1dA-5o0sA:
undetectable
4y1dD-5o0sA:
undetectable		 4y1dA-5o0sA:
12.52
4y1dD-5o0sA:
1.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oqm MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 11

(Saccharomyces
cerevisiae) 		no annotation 3 GLU c  42
LYS c  45
ASN c  41
 None
 0.87A 4y1dA-5oqmc:
undetectable
4y1dD-5oqmc:
undetectable		 4y1dA-5oqmc:
undetectable
4y1dD-5oqmc:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oyp STRUCTURAL PROTEIN
VP2

(Sacbrood virus) 		no annotation 3 GLU B  20
LYS B  18
ASN B  59
 None
 1.04A 4y1dA-5oypB:
undetectable
4y1dD-5oypB:
undetectable		 4y1dA-5oypB:
undetectable
4y1dD-5oypB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tzy FREE FATTY ACID
RECEPTOR
1,ENDOLYSIN,FREE
FATTY ACID RECEPTOR
1

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		3 GLU A1064
LYS A1062
ASN A1068
 None
 0.69A 4y1dA-5tzyA:
undetectable
4y1dD-5tzyA:
undetectable		 4y1dA-5tzyA:
16.46
4y1dD-5tzyA:
1.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5up1 EEHEE_RD3_1049

(Escherichia
coli) 		no annotation 3 GLU A  37
LYS A  40
ASN A  35
 None
 0.94A 4y1dA-5up1A:
undetectable
4y1dD-5up1A:
undetectable		 4y1dA-5up1A:
22.29
4y1dD-5up1A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vj4 UNCHARACTERIZED
PROTEIN

(Borrelia
turicatae) 		no annotation 3 GLU A 364
LYS A 426
ASN A 367
 None
 1.08A 4y1dA-5vj4A:
undetectable
4y1dD-5vj4A:
undetectable		 4y1dA-5vj4A:
18.75
4y1dD-5vj4A:
3.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vto BLASTICIDIN M

(Streptomyces
griseochromogenes) 		no annotation 3 GLU A  83
LYS A  86
ASN A  59
 None
 1.00A 4y1dA-5vtoA:
undetectable
4y1dD-5vtoA:
undetectable		 4y1dA-5vtoA:
undetectable
4y1dD-5vtoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x18 CASEIN KINASE I
HOMOLOG 1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		3 GLU A 100
LYS A  98
ASN A 138
 None
GOL  A 402 (-3.2A)
None
 1.06A 4y1dA-5x18A:
undetectable
4y1dD-5x18A:
undetectable		 4y1dA-5x18A:
21.55
4y1dD-5x18A:
5.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)

(Cryptosporidium
parvum) 		no annotation 3 GLU A 424
LYS A 420
ASN A 423
 None
 0.99A 4y1dA-5xioA:
undetectable
4y1dD-5xioA:
undetectable		 4y1dA-5xioA:
undetectable
4y1dD-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6amz 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E

(Acinetobacter
baumannii) 		PF00132
(Hexapep)
PF14602
(Hexapep_2)
PF14805
(THDPS_N_2) 		3 GLU A 136
LYS A 154
ASN A 120
 None
 1.08A 4y1dA-6amzA:
undetectable
4y1dD-6amzA:
undetectable		 4y1dA-6amzA:
22.83
4y1dD-6amzA:
4.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b0t FASCIN

(Homo sapiens) 		no annotation 3 GLU A 417
LYS A 426
ASN A 424
 None
 0.94A 4y1dA-6b0tA:
undetectable
4y1dD-6b0tA:
undetectable		 4y1dA-6b0tA:
undetectable
4y1dD-6b0tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byk 14-3-3 PROTEIN
BETA/ALPHA

(Homo sapiens) 		no annotation 3 GLU A 210
LYS A 214
ASN A 209
 None
 0.93A 4y1dA-6bykA:
undetectable
4y1dD-6bykA:
undetectable		 4y1dA-6bykA:
undetectable
4y1dD-6bykA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6s -

(-) 		no annotation 3 GLU D 149
LYS D 151
ASN D 144
 None
 1.01A 4y1dA-6c6sD:
undetectable
4y1dD-6c6sD:
undetectable		 4y1dA-6c6sD:
undetectable
4y1dD-6c6sD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ckt 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E

(Legionella
pneumophila) 		no annotation 3 GLU A 136
LYS A 154
ASN A 120
 None
 0.93A 4y1dA-6cktA:
undetectable
4y1dD-6cktA:
undetectable		 4y1dA-6cktA:
undetectable
4y1dD-6cktA:
undetectable