SIMILAR PATTERNS OF AMINO ACIDS FOR 4Y0S_A_PX9A201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a1z FADD PROTEIN

(Homo sapiens) 		PF01335
(DED) 		5 VAL A  39
LEU A  63
LEU A  67
VAL A  11
LEU A   8
 None
 0.95A 4y0sA-1a1zA:
undetectable		 4y0sA-1a1zA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ako EXONUCLEASE III

(Escherichia
coli) 		PF03372
(Exo_endo_phos) 		5 LEU A  32
LEU A  11
ILE A   8
VAL A  47
LEU A  68
 None
 0.97A 4y0sA-1akoA:
0.0		 4y0sA-1akoA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhg BETA-GLUCURONIDASE

(Homo sapiens) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		5 LEU A 166
ILE A 168
ILE A 123
VAL A 119
LEU A 156
 None
 0.91A 4y0sA-1bhgA:
0.3		 4y0sA-1bhgA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ecx AMINOTRANSFERASE

(Thermotoga
maritima) 		PF00266
(Aminotran_5) 		5 LEU A 373
LEU A 307
ILE A 369
ILE A 351
VAL A 297
 None
 0.99A 4y0sA-1ecxA:
undetectable		 4y0sA-1ecxA:
16.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1exs BETA-LACTOGLOBULIN

(Sus scrofa) 		PF00061
(Lipocalin) 		5 LEU A  46
LEU A  54
ILE A  56
GLU A  62
MET A 107
 None
 0.70A 4y0sA-1exsA:
14.9		 4y0sA-1exsA:
63.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1exs BETA-LACTOGLOBULIN

(Sus scrofa) 		PF00061
(Lipocalin) 		5 LEU A  46
LEU A  54
ILE A  56
ILE A  84
LEU A 103
 None
 0.55A 4y0sA-1exsA:
14.9		 4y0sA-1exsA:
63.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1exs BETA-LACTOGLOBULIN

(Sus scrofa) 		PF00061
(Lipocalin) 		5 LEU A  46
LEU A  54
ILE A  56
LEU A 103
MET A 107
 None
 0.80A 4y0sA-1exsA:
14.9		 4y0sA-1exsA:
63.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fxj UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE

(Escherichia
coli) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		5 VAL A 131
LEU A 114
LEU A 102
ILE A 172
VAL A 106
 VAL  A 131 ( 0.6A)
LEU  A 114 ( 0.6A)
LEU  A 102 ( 0.6A)
ILE  A 172 ( 0.7A)
VAL  A 106 ( 0.6A)
 0.95A 4y0sA-1fxjA:
0.0		 4y0sA-1fxjA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8w LEUCOAGGLUTINATING
PHYTOHEMAGGLUTININ

(Phaseolus
vulgaris) 		PF00139
(Lectin_legB) 		5 LEU A  92
LEU A 199
ILE A  57
LYS A   1
VAL A 193
 None
 0.86A 4y0sA-1g8wA:
0.0		 4y0sA-1g8wA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ga8 GALACTOSYL
TRANSFERASE LGTC

(Neisseria
meningitidis) 		PF01501
(Glyco_transf_8) 		5 VAL A 108
LEU A  52
VAL A  35
LEU A  15
PHE A   5
 None
 0.95A 4y0sA-1ga8A:
0.0		 4y0sA-1ga8A:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kum GLUCOAMYLASE

(Aspergillus
niger) 		PF00686
(CBM_20) 		5 LEU A 540
LEU A 533
ILE A 549
VAL A 517
LEU A 569
 None
 0.76A 4y0sA-1kumA:
undetectable		 4y0sA-1kumA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mor GLUCOSAMINE
6-PHOSPHATE SYNTHASE

(Escherichia
coli) 		PF01380
(SIS) 		6 LEU A 389
LEU A 371
ILE A 373
GLU A 481
ILE A 297
LEU A 278
 None
 1.10A 4y0sA-1morA:
0.0		 4y0sA-1morA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pww LETHAL FACTOR

(Bacillus
anthracis) 		PF07737
(ATLF)
PF09156
(Anthrax-tox_M) 		5 LEU A 114
ILE A 104
GLU A 212
VAL A 130
LEU A  94
 None
 0.85A 4y0sA-1pwwA:
undetectable		 4y0sA-1pwwA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sbd SOYBEAN AGGLUTININ

(Glycine max) 		PF00139
(Lectin_legB) 		5 LEU A  94
LEU A 200
ILE A  59
LYS A   1
VAL A 194
 None
 0.98A 4y0sA-1sbdA:
undetectable		 4y0sA-1sbdA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ugk SYNAPTOTAGMIN IV

(Homo sapiens) 		PF00168
(C2) 		6 LEU A 115
LEU A 120
ILE A 118
VAL A  26
LEU A  92
PHE A  13
 None
 1.38A 4y0sA-1ugkA:
undetectable		 4y0sA-1ugkA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uh9 HIZOPUSPEPSIN I

(Rhizopus
microsporus) 		PF00026
(Asp) 		5 LEU A 224
ILE A 299
ILE A 197
VAL A 199
LEU A 260
 None
 0.88A 4y0sA-1uh9A:
undetectable		 4y0sA-1uh9A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE

(Thermus
thermophilus) 		PF01070
(FMN_dh) 		5 LEU A 204
VAL A 184
VAL A 186
LEU A 126
PHE A 151
 None
 0.92A 4y0sA-1vcgA:
undetectable		 4y0sA-1vcgA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vg0 RAB PROTEINS
GERANYLGERANYLTRANSF
ERASE COMPONENT A 1

(Rattus
norvegicus) 		PF00996
(GDI) 		5 LEU A  55
VAL A  98
LEU A 547
PHE A 549
MET A 551
 None
 0.94A 4y0sA-1vg0A:
undetectable		 4y0sA-1vg0A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		5 VAL A 623
LEU A 539
ILE A 541
ILE A 566
VAL A 553
 None
None
None
BR  A1664 ( 4.6A)
None
 0.96A 4y0sA-1w99A:
undetectable		 4y0sA-1w99A:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xf1 C5A PEPTIDASE

(Streptococcus
pyogenes) 		PF00082
(Peptidase_S8)
PF02225
(PA)
PF06280
(fn3_5)
PF13585
(CHU_C) 		5 LEU A 947
LEU A 989
ILE A 964
GLU A1013
LEU A1028
 None
 0.95A 4y0sA-1xf1A:
undetectable		 4y0sA-1xf1A:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xg2 PECTINESTERASE 1

(Solanum
lycopersicum) 		PF01095
(Pectinesterase) 		5 VAL A   7
LEU A  55
ILE A  57
ILE A  67
VAL A  46
 None
 0.89A 4y0sA-1xg2A:
undetectable		 4y0sA-1xg2A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xwc THIOREDOXIN

(Drosophila
melanogaster) 		PF00085
(Thioredoxin) 		6 VAL A  87
LEU A  98
LEU A  45
ILE A 106
VAL A  53
VAL A  55
 None
 1.27A 4y0sA-1xwcA:
undetectable		 4y0sA-1xwcA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ytu HYPOTHETICAL PROTEIN
AF1318

(Archaeoglobus
fulgidus) 		PF02171
(Piwi) 		5 LEU A  64
ILE A  68
ILE A  49
VAL A 114
LEU A 144
 None
 0.97A 4y0sA-1ytuA:
undetectable		 4y0sA-1ytuA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE

(Thermotoga
maritima) 		PF00294
(PfkB) 		5 LEU A 202
LEU A 165
ILE A 198
ILE A 239
VAL A 237
 None
 0.96A 4y0sA-2afbA:
undetectable		 4y0sA-2afbA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cya TYROSYL-TRNA
SYNTHETASE

(Aeropyrum
pernix) 		PF00579
(tRNA-synt_1b) 		5 VAL A 330
LEU A  53
ILE A 283
ILE A 214
VAL A 250
 None
 0.98A 4y0sA-2cyaA:
undetectable		 4y0sA-2cyaA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0o DIOL
DEHYDRATASE-REACTIVA
TING FACTOR LARGE
SUBUNIT

(Klebsiella
oxytoca) 		PF08841
(DDR) 		5 LEU A 332
ILE A 359
VAL A 277
VAL A 275
LEU A 266
 None
 0.98A 4y0sA-2d0oA:
undetectable		 4y0sA-2d0oA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dlu INAD-LIKE PROTEIN

(Homo sapiens) 		PF00595
(PDZ) 		5 VAL A  19
LEU A  83
ILE A  45
VAL A  42
VAL A  40
 None
 0.97A 4y0sA-2dluA:
undetectable		 4y0sA-2dluA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e5v L-ASPARTATE OXIDASE

(Sulfurisphaera
tokodaii) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 LEU A 170
LEU A 332
ILE A 319
GLU A 207
LEU A 141
 None
None
None
None
FAD  A1002 (-4.6A)
 0.96A 4y0sA-2e5vA:
undetectable		 4y0sA-2e5vA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9i ACETYL-COENZYME A
CARBOXYLASE CARBOXYL
TRANSFERASE SUBUNIT
BETA

(Staphylococcus
aureus) 		PF01039
(Carboxyl_trans) 		6 VAL B 127
LEU B 273
ILE B  70
GLU B  78
VAL B 264
LEU B 221
 None
 1.42A 4y0sA-2f9iB:
undetectable		 4y0sA-2f9iB:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fa0 HMG-COA SYNTHASE

(Brassica juncea) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		5 LEU A 142
LEU A  78
ILE A 144
ILE A  92
LEU A  65
 None
 0.99A 4y0sA-2fa0A:
undetectable		 4y0sA-2fa0A:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fa0 HMG-COA SYNTHASE

(Brassica juncea) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		5 LEU A 368
LEU A 370
ILE A 175
ILE A 382
VAL A 340
 None
 0.99A 4y0sA-2fa0A:
undetectable		 4y0sA-2fa0A:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hmf PROBABLE
ASPARTOKINASE

(Methanocaldococcus
jannaschii) 		PF00696
(AA_kinase)
PF01842
(ACT)
PF13840
(ACT_7) 		5 ILE A 187
VAL A  37
VAL A  39
PHE A   7
MET A   5
 None
 0.96A 4y0sA-2hmfA:
undetectable		 4y0sA-2hmfA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i04 MEMBRANE-ASSOCIATED
GUANYLATE KINASE, WW
AND PDZ
DOMAIN-CONTAINING
PROTEIN 1

(Mus musculus) 		PF00595
(PDZ) 		5 VAL A 516
LEU A 530
LEU A 532
ILE A 499
LEU A 455
 None
 0.98A 4y0sA-2i04A:
undetectable		 4y0sA-2i04A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0z NAD(FAD)-UTILIZING
DEHYDROGENASES

(Bacillus cereus) 		PF03486
(HI0933_like) 		5 LEU A  29
LEU A 154
ILE A   6
ILE A 136
VAL A 133
 None
None
None
None
FAD  A 501 (-3.9A)
 0.98A 4y0sA-2i0zA:
undetectable		 4y0sA-2i0zA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF01380
(SIS)
PF13522
(GATase_6) 		6 LEU A 389
LEU A 371
ILE A 373
GLU A 481
ILE A 297
LEU A 278
 None
 1.05A 4y0sA-2j6hA:
undetectable		 4y0sA-2j6hA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgp TYROCIDINE
SYNTHETASE 3

(Brevibacillus
brevis) 		PF00550
(PP-binding)
PF00668
(Condensation) 		5 LEU A  75
LEU A  17
ILE A  79
VAL A  49
LEU A  66
 None
 0.97A 4y0sA-2jgpA:
undetectable		 4y0sA-2jgpA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2v DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 5

(Homo sapiens) 		PF00564
(PB1) 		5 LEU A 102
ILE A 104
ILE A  48
VAL A  44
LEU A  82
 None
 0.78A 4y0sA-2o2vA:
undetectable		 4y0sA-2o2vA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oqz SORTASE B

(Bacillus
anthracis) 		PF04203
(Sortase) 		5 LEU A 166
ILE A  85
VAL A 228
VAL A 246
LEU A 151
 None
 0.94A 4y0sA-2oqzA:
undetectable		 4y0sA-2oqzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ow4 CANAVALIA MARITIMA
LECTIN

(Canavalia rosea) 		PF00139
(Lectin_legB) 		5 VAL A  65
LEU A  93
LEU A 156
ILE A 210
ILE A 199
 None
 0.95A 4y0sA-2ow4A:
undetectable		 4y0sA-2ow4A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q01 URONATE ISOMERASE

(Caulobacter
vibrioides) 		PF02614
(UxaC) 		5 LEU A 421
LEU A  59
GLU A 129
LEU A 157
PHE A 152
 None
 0.88A 4y0sA-2q01A:
undetectable		 4y0sA-2q01A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6f EXCINUCLEASE ABC
SUBUNIT A

(Geobacillus
stearothermophilus) 		PF00005
(ABC_tran) 		5 LEU A 610
LEU A 651
ILE A 672
VAL A 681
LEU A 678
 None
 0.93A 4y0sA-2r6fA:
undetectable		 4y0sA-2r6fA:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6f EXCINUCLEASE ABC
SUBUNIT A

(Geobacillus
stearothermophilus) 		PF00005
(ABC_tran) 		5 VAL A 635
LEU A 849
LEU A 655
VAL A 612
LEU A 629
 None
 0.86A 4y0sA-2r6fA:
undetectable		 4y0sA-2r6fA:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rb9 HYPE PROTEIN

(Escherichia
coli) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		6 LEU A 275
LEU A 219
ILE A 207
ILE A 157
VAL A 287
LEU A 291
 None
 1.33A 4y0sA-2rb9A:
undetectable		 4y0sA-2rb9A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ro1 TRANSCRIPTION
INTERMEDIARY FACTOR
1-BETA

(Homo sapiens) 		PF00628
(PHD) 		6 LEU A 740
ILE A 743
VAL A 707
LEU A 788
PHE A 792
MET A 796
 None
 1.25A 4y0sA-2ro1A:
undetectable		 4y0sA-2ro1A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		5 VAL A 299
LEU A 410
LEU A 406
VAL A 342
MET A 335
 None
 0.99A 4y0sA-2vdcA:
undetectable		 4y0sA-2vdcA:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vvf MAJOR CAPSID PROTEIN
P2

(Pseudoalteromonas
virus PM2) 		no annotation 5 VAL A  47
LEU A  23
LEU A   7
ILE A  21
PHE A  83
 None
 0.97A 4y0sA-2vvfA:
undetectable		 4y0sA-2vvfA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR

(Methanothermobacter
thermautotrophicus) 		PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		6 LEU A 428
GLU A 491
ILE A 448
VAL A 415
VAL A 533
LEU A 397
 None
 1.34A 4y0sA-2ycbA:
undetectable		 4y0sA-2ycbA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK

([Ruminococcus]
gnavus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		5 LEU A 673
LEU A 632
ILE A 640
VAL A 657
PHE A 715
 None
 0.91A 4y0sA-2yfnA:
undetectable		 4y0sA-2yfnA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z0u WW DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00168
(C2) 		6 LEU A  29
ILE A  27
ILE A  61
VAL A  63
VAL A  65
LEU A 130
 None
 0.87A 4y0sA-2z0uA:
undetectable		 4y0sA-2z0uA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwg UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR YYDK

(Bacillus
subtilis) 		PF00392
(GntR)
PF07702
(UTRA) 		5 LEU A 175
LEU A 177
ILE A 201
VAL A 229
LEU A  78
 None
 0.93A 4y0sA-3bwgA:
undetectable		 4y0sA-3bwgA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bws PROTEIN LP49

(Leptospira
interrogans) 		PF10282
(Lactonase) 		5 LEU A 282
LEU A 291
ILE A 293
GLU A 302
VAL A 261
 None
 0.90A 4y0sA-3bwsA:
undetectable		 4y0sA-3bwsA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb2 PUTATIVE
DIHYDRODIPICOLINATE
SYNTHETASE

(Rhodopseudomonas
palustris) 		PF00701
(DHDPS) 		5 ILE A 212
ILE A 291
VAL A 242
LEU A 251
PHE A 246
 None
 0.98A 4y0sA-3eb2A:
undetectable		 4y0sA-3eb2A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f83 FUSION OF THE MINOR
PILIN CFAE AND MAJOR
PILIN CFAB

(Escherichia
coli) 		PF04449
(Fimbrial_CS1)
PF07434
(CblD) 		5 LEU A 381
VAL A 424
VAL A 422
LEU A 465
PHE A 460
 None
 0.86A 4y0sA-3f83A:
undetectable		 4y0sA-3f83A:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f85 HOMO TRIMERIC FUSION
OF CFA/I FIMBRIAL
SUBUNITS B

(Escherichia
coli) 		PF04449
(Fimbrial_CS1) 		5 LEU A   4
VAL A  47
VAL A  45
LEU A  88
PHE A  83
 None
 0.90A 4y0sA-3f85A:
undetectable		 4y0sA-3f85A:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f85 HOMO TRIMERIC FUSION
OF CFA/I FIMBRIAL
SUBUNITS B

(Escherichia
coli) 		PF04449
(Fimbrial_CS1) 		5 LEU A 155
VAL A 198
VAL A 196
LEU A 239
PHE A 234
 None
 0.88A 4y0sA-3f85A:
undetectable		 4y0sA-3f85A:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f85 HOMO TRIMERIC FUSION
OF CFA/I FIMBRIAL
SUBUNITS B

(Escherichia
coli) 		PF04449
(Fimbrial_CS1) 		5 LEU A 306
VAL A 349
VAL A 347
LEU A 390
PHE A 385
 None
 0.84A 4y0sA-3f85A:
undetectable		 4y0sA-3f85A:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fii BOTULINUM NEUROTOXIN
TYPE F

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		6 VAL A   3
LEU A 229
LEU A 225
ILE A  98
VAL A 155
LEU A 153
 None
 1.43A 4y0sA-3fiiA:
undetectable		 4y0sA-3fiiA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fww BIFUNCTIONAL PROTEIN
GLMU

(Yersinia pestis) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		5 VAL A 131
LEU A 114
LEU A 102
ILE A 172
VAL A 106
 None
 0.96A 4y0sA-3fwwA:
undetectable		 4y0sA-3fwwA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhe RIBOSE-5-PHOSPHATE
ISOMERASE A

(Bartonella
henselae) 		PF06026
(Rib_5-P_isom_A) 		5 LEU A  45
ILE A  47
ILE A  90
VAL A  88
LEU A  36
 None
 0.93A 4y0sA-3hheA:
undetectable		 4y0sA-3hheA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00109
(ketoacyl-synt)
PF01648
(ACPS)
PF02801
(Ketoacyl-synt_C) 		5 LEU A 679
ILE A 752
ILE A 733
VAL A 735
PHE A 394
 None
 0.96A 4y0sA-3hmjA:
undetectable		 4y0sA-3hmjA:
6.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i2m ORF59

(Human
gammaherpesvirus
8) 		PF04929
(Herpes_DNAp_acc) 		6 LEU X 252
LEU X 256
ILE X 253
LYS X 186
VAL X 295
LEU X 297
 None
 1.47A 4y0sA-3i2mX:
undetectable		 4y0sA-3i2mX:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibm CUPIN 2, CONSERVED
BARREL DOMAIN
PROTEIN

(Halorhodospira
halophila) 		PF07883
(Cupin_2) 		5 ILE A 104
VAL A  78
VAL A  80
LEU A 121
PHE A 123
 None
 0.83A 4y0sA-3ibmA:
undetectable		 4y0sA-3ibmA:
21.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kza BETA-LACTOGLOBULIN

(Equus caballus;
Bos taurus) 		PF00061
(Lipocalin) 		7 LEU A  46
LEU A  54
ILE A  56
ILE A  84
VAL A  92
LEU A 122
MET A 107
 None
 1.38A 4y0sA-3kzaA:
25.2		 4y0sA-3kzaA:
78.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kza BETA-LACTOGLOBULIN

(Equus caballus;
Bos taurus) 		PF00061
(Lipocalin) 		6 LEU A  54
ILE A  71
VAL A  94
LEU A 103
PHE A 105
MET A 107
 None
 1.38A 4y0sA-3kzaA:
25.2		 4y0sA-3kzaA:
78.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kza BETA-LACTOGLOBULIN

(Equus caballus;
Bos taurus) 		PF00061
(Lipocalin) 		11 VAL A  41
LEU A  46
LEU A  54
ILE A  56
LYS A  60
ILE A  84
VAL A  92
VAL A  94
LEU A 103
PHE A 105
MET A 107
 None
 0.82A 4y0sA-3kzaA:
25.2		 4y0sA-3kzaA:
78.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM

(Homo sapiens) 		PF00149
(Metallophos) 		6 LEU A 209
LEU A  78
ILE A 212
ILE A 230
VAL A 198
LEU A 274
 None
 1.34A 4y0sA-3ll8A:
undetectable		 4y0sA-3ll8A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0u PROBABLE
N-GLYCOSYLASE/DNA
LYASE

(Thermotoga
maritima) 		no annotation 5 LEU A 197
LEU A   8
GLU A  24
VAL A 182
LEU A 179
 None
 0.94A 4y0sA-3n0uA:
undetectable		 4y0sA-3n0uA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odp PUTATIVE
TAGATOSE-6-PHOSPHATE
KETOSE/ALDOSE
ISOMERASE

(Clostridium
novyi) 		PF01380
(SIS) 		5 LEU A 163
LEU A 140
ILE A 142
GLU A 246
ILE A  62
 None
 0.83A 4y0sA-3odpA:
undetectable		 4y0sA-3odpA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p11 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		5 LEU A  58
LEU A  80
ILE A  61
VAL A  68
VAL A  70
 None
 0.95A 4y0sA-3p11A:
undetectable		 4y0sA-3p11A:
14.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ph5 BETA-LACTOGLOBULIN

(Bos taurus) 		PF00061
(Lipocalin) 		6 LEU A  62
LEU A  70
ILE A  72
ILE A 100
VAL A 108
LEU A 138
 None
 1.38A 4y0sA-3ph5A:
28.8		 4y0sA-3ph5A:
96.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ph5 BETA-LACTOGLOBULIN

(Bos taurus) 		PF00061
(Lipocalin) 		11 VAL A  57
LEU A  62
LEU A  70
ILE A  72
LYS A  76
GLU A  78
ILE A 100
VAL A 108
VAL A 110
LEU A 119
PHE A 121
 None
 0.72A 4y0sA-3ph5A:
28.8		 4y0sA-3ph5A:
96.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ph5 BETA-LACTOGLOBULIN

(Bos taurus) 		PF00061
(Lipocalin) 		11 VAL A  57
LEU A  62
LEU A  70
ILE A  72
LYS A  76
GLU A  78
VAL A 108
VAL A 110
LEU A 119
PHE A 121
MET A 123
 None
 0.67A 4y0sA-3ph5A:
28.8		 4y0sA-3ph5A:
96.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pie 5'->3'
EXORIBONUCLEASE
(XRN1)

(Kluyveromyces
lactis) 		PF03159
(XRN_N) 		5 LEU A 541
ILE A 330
ILE A 578
VAL A 570
LEU A 339
 None
 0.97A 4y0sA-3pieA:
undetectable		 4y0sA-3pieA:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6k ACETYLGLUTAMATE
KINASE

(Xanthomonas
campestris) 		PF00696
(AA_kinase)
PF04768
(NAT) 		5 VAL A  70
LEU A  32
LEU A  19
ILE A  15
PHE A 282
 None
 0.90A 4y0sA-3s6kA:
2.5		 4y0sA-3s6kA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t05 PYRUVATE KINASE

(Staphylococcus
aureus) 		PF00224
(PK)
PF00391
(PEP-utilizers)
PF02887
(PK_C) 		5 LEU A 130
LEU A 123
ILE A 121
ILE A  72
VAL A 106
 None
 0.87A 4y0sA-3t05A:
undetectable		 4y0sA-3t05A:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ta6 TRIOSEPHOSPHATE
ISOMERASE

(Mycobacterium
tuberculosis) 		PF00121
(TIM) 		5 VAL A 233
LEU A 199
LEU A 152
ILE A 195
VAL A 130
 None
 0.96A 4y0sA-3ta6A:
undetectable		 4y0sA-3ta6A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8i DOPAMINE N
ACETYLTRANSFERASE,
ISOFORM A

(Drosophila
melanogaster) 		PF00583
(Acetyltransf_1) 		5 VAL A  78
LEU A  89
LEU A  69
ILE A  27
LEU A  39
 None
 0.99A 4y0sA-3v8iA:
undetectable		 4y0sA-3v8iA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aec CYSTEINE SYNTHASE,
MITOCHONDRIAL

(Arabidopsis
thaliana) 		PF00291
(PALP) 		6 VAL A 285
LEU A 366
GLU A 350
ILE A 386
VAL A 127
LEU A 144
 None
 1.49A 4y0sA-4aecA:
undetectable		 4y0sA-4aecA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bin N-ACETYLMURAMOYL-L-A
LANINE AMIDASE AMIC

(Escherichia
coli) 		PF01520
(Amidase_3)
PF11741
(AMIN) 		6 VAL A  39
ILE A  75
VAL A  73
VAL A  71
LEU A 142
PHE A 115
 None
 1.25A 4y0sA-4binA:
undetectable		 4y0sA-4binA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bin N-ACETYLMURAMOYL-L-A
LANINE AMIDASE AMIC

(Escherichia
coli) 		PF01520
(Amidase_3)
PF11741
(AMIN) 		6 VAL A  39
LEU A 125
ILE A  75
VAL A  71
LEU A 142
PHE A 115
 None
 1.14A 4y0sA-4binA:
undetectable		 4y0sA-4binA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bin N-ACETYLMURAMOYL-L-A
LANINE AMIDASE AMIC

(Escherichia
coli) 		PF01520
(Amidase_3)
PF11741
(AMIN) 		6 VAL A  39
VAL A  73
VAL A  71
LEU A 142
PHE A 115
MET A 113
 None
 1.15A 4y0sA-4binA:
undetectable		 4y0sA-4binA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bub UDP-N-ACETYLMURAMOYL
-L-ALANYL-D-GLUTAMAT
E--LD-LYSINE LIGASE

(Thermotoga
maritima) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 LEU A 125
LEU A 304
ILE A 121
ILE A 197
VAL A 195
 None
 0.81A 4y0sA-4bubA:
undetectable		 4y0sA-4bubA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4df9 PUTATIVE PEPTIDASE

(Bacteroides
fragilis) 		PF09471
(Peptidase_M64)
PF16217
(M64_N) 		5 LEU A  51
LEU A  31
ILE A  33
ILE A  75
VAL A 126
 None
 0.89A 4y0sA-4df9A:
undetectable		 4y0sA-4df9A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dh2 CELLULOSOME
ANCHORING PROTEIN
COHESIN REGION

(Ruminiclostridium
thermocellum) 		PF00963
(Cohesin) 		6 LEU A  36
LEU A  53
GLU A 161
ILE A  60
VAL A  62
VAL A  65
 None
 1.37A 4y0sA-4dh2A:
undetectable		 4y0sA-4dh2A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewl 1D-MYO-INOSITOL
2-ACETAMIDO-2-DEOXY-
ALPHA-D-GLUCOPYRANOS
IDE DEACETYLASE

(Mycobacterium
tuberculosis) 		PF02585
(PIG-L) 		5 VAL A 227
LEU A  79
VAL A  35
VAL A  37
PHE A   9
 None
None
GOL  A 402 (-4.4A)
None
None
 0.99A 4y0sA-4ewlA:
undetectable		 4y0sA-4ewlA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1

(Caenorhabditis
elegans) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		6 LEU A1110
ILE A1270
ILE A1238
VAL A1077
LEU A1098
PHE A1079
 None
 1.35A 4y0sA-4f4cA:
undetectable		 4y0sA-4f4cA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1

(Caenorhabditis
elegans) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		6 LEU A1110
LEU A1108
ILE A1270
VAL A1077
LEU A1098
PHE A1079
 None
 1.17A 4y0sA-4f4cA:
undetectable		 4y0sA-4f4cA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fg0 POLYPROTEIN

(Saint Louis
encephalitis
virus) 		PF00869
(Flavi_glycoprot)
PF02832
(Flavi_glycop_C) 		5 VAL A 186
ILE A 297
VAL A  33
LEU A  25
PHE A  43
 None
 0.97A 4y0sA-4fg0A:
undetectable		 4y0sA-4fg0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g7a CARBONATE
DEHYDRATASE

(Sulfurihydrogenibium
sp. YO3AOP1) 		PF00194
(Carb_anhydrase) 		5 LEU A 134
LEU A 138
ILE A 137
GLU A  72
LEU A 105
 None
 0.95A 4y0sA-4g7aA:
undetectable		 4y0sA-4g7aA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h87 KANADAPTIN

(Homo sapiens) 		PF00498
(FHA) 		5 LEU A 169
VAL A 259
VAL A 257
LEU A 213
PHE A 231
 None
 0.97A 4y0sA-4h87A:
undetectable		 4y0sA-4h87A:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i7i RYANODINE RECEPTOR 1

(Oryctolagus
cuniculus) 		PF01365
(RYDR_ITPR)
PF02815
(MIR)
PF08709
(Ins145_P3_rec) 		5 LEU A 262
LEU A 280
ILE A 282
VAL A 348
LEU A 390
 None
 0.94A 4y0sA-4i7iA:
undetectable		 4y0sA-4i7iA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i96 RYANODINE RECEPTOR 1

(Oryctolagus
cuniculus) 		PF01365
(RYDR_ITPR)
PF02815
(MIR) 		5 LEU A 262
LEU A 280
ILE A 282
VAL A 348
LEU A 390
 None
 0.86A 4y0sA-4i96A:
undetectable		 4y0sA-4i96A:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4il1 CALMODULIN,
CALCINEURIN SUBUNIT
B TYPE 1,
SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM

(Rattus
norvegicus) 		PF00149
(Metallophos)
PF13499
(EF-hand_7) 		5 LEU A 542
LEU A 411
ILE A 545
VAL A 531
LEU A 607
 None
 0.96A 4y0sA-4il1A:
undetectable		 4y0sA-4il1A:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4leo RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		5 LEU C  58
LEU C  80
ILE C  61
VAL C  68
VAL C  70
 None
 0.93A 4y0sA-4leoC:
undetectable		 4y0sA-4leoC:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ltm NADH-DEPENDENT FMN
REDUCTASE

(EDTA-degrading
bacterium BNC1) 		PF03358
(FMN_red) 		6 LEU A 108
LEU A 106
ILE A  74
ILE A   5
VAL A  29
LEU A 164
 None
 1.18A 4y0sA-4ltmA:
undetectable		 4y0sA-4ltmA:
25.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m3c LECTIN BETA CHAIN

(Butea
monosperma) 		PF00139
(Lectin_legB) 		5 LEU B  94
LEU B 204
ILE B  59
LYS B   1
VAL B 198
 None
 0.98A 4y0sA-4m3cB:
undetectable		 4y0sA-4m3cB:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mix PUTATIVE
INSECTICIDAL TOXIN

(Photorhabdus
asymbiotica) 		PF04488
(Gly_transf_sug) 		6 VAL A2249
LEU A2265
LEU A2328
ILE A2261
LYS A2254
LEU A2237
 None
 1.37A 4y0sA-4mixA:
undetectable		 4y0sA-4mixA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nq3 CYANURIC ACID
AMIDOHYDROLASE

(Azorhizobium
caulinodans) 		PF09663
(Amido_AtzD_TrzD) 		5 LEU A 239
LEU A 107
ILE A 109
GLU A  73
LEU A 283
 None
 0.92A 4y0sA-4nq3A:
undetectable		 4y0sA-4nq3A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4og1 ENOYL-COA
HYDRATASE/ISOMERASE

(Novosphingobium
aromaticivorans) 		PF00378
(ECH_1) 		5 ILE A  14
VAL A  12
VAL A  10
PHE A   6
MET A   4
 None
 0.95A 4y0sA-4og1A:
undetectable		 4y0sA-4og1A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4orb SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM

(Mus musculus) 		PF00149
(Metallophos) 		6 LEU A 209
LEU A  78
ILE A 212
ILE A 230
VAL A 198
LEU A 274
 None
 1.35A 4y0sA-4orbA:
undetectable		 4y0sA-4orbA:
14.94