SIMILAR PATTERNS OF AMINO ACIDS FOR 4Y0Q_A_PX9A201_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aj8 CITRATE SYNTHASE

(Pyrococcus
furiosus) 		PF00285
(Citrate_synt) 		3 LYS A 219
ILE A 215
ILE A 102
 None
 0.67A 4y0qA-1aj8A:
0.0		 4y0qA-1aj8A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c07 PROTEIN (EPIDERMAL
GROWTH FACTOR
RECEPTOR PATHWAY
SUBSTRATE 15)

(Homo sapiens) 		PF12763
(EF-hand_4) 		3 LYS A  19
ILE A  23
ILE A  43
 None
 0.68A 4y0qA-1c07A:
undetectable		 4y0qA-1c07A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c9l CLATHRIN

(Rattus
norvegicus) 		PF01394
(Clathrin_propel)
PF09268
(Clathrin-link) 		3 LYS A  96
ILE A  93
ILE A  52
 None
 0.72A 4y0qA-1c9lA:
0.0		 4y0qA-1c9lA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6s O-ACETYLSERINE
SULFHYDRYLASE

(Salmonella
enterica) 		PF00291
(PALP) 		3 LYS A 292
ILE A 294
ILE A 172
 None
 0.68A 4y0qA-1d6sA:
0.0		 4y0qA-1d6sA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dk5 ANNEXIN 24(CA32)

(Capsicum annuum) 		PF00191
(Annexin) 		3 LYS A 190
ILE A 187
ILE A 224
 None
 0.62A 4y0qA-1dk5A:
undetectable		 4y0qA-1dk5A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dl3 PROTEIN
(PHOSPHORIBOSYLANTRA
NILATE ISOMERASE)

(Thermotoga
maritima) 		PF00697
(PRAI) 		3 LYS A 190
ILE A 195
ILE A 199
 None
 0.68A 4y0qA-1dl3A:
0.0		 4y0qA-1dl3A:
26.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dub 2-ENOYL-COA
HYDRATASE

(Rattus
norvegicus) 		PF00378
(ECH_1) 		3 LYS A 128
ILE A  85
ILE A  50
 None
 0.70A 4y0qA-1dubA:
0.2		 4y0qA-1dubA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dxe 2-DEHYDRO-3-DEOXY-GA
LACTARATE ALDOLASE

(Escherichia
coli) 		PF03328
(HpcH_HpaI) 		3 LYS A 211
ILE A 173
ILE A 152
 None
 0.71A 4y0qA-1dxeA:
0.0		 4y0qA-1dxeA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eo1 HYPOTHETICAL PROTEIN
MTH1175

(Methanothermobacter
thermautotrophicus) 		PF02579
(Nitro_FeMo-Co) 		3 LYS A   2
ILE A  28
ILE A  42
 None
 0.64A 4y0qA-1eo1A:
0.0		 4y0qA-1eo1A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g71 DNA PRIMASE

(Pyrococcus
furiosus) 		PF01896
(DNA_primase_S) 		3 LYS A 239
ILE A 235
ILE A 227
 None
 0.72A 4y0qA-1g71A:
0.0		 4y0qA-1g71A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3e TYROSYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00579
(tRNA-synt_1b) 		3 LYS A 114
ILE A 305
ILE A 309
 None
 0.53A 4y0qA-1h3eA:
0.0		 4y0qA-1h3eA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ji0 ABC TRANSPORTER

(Thermotoga
maritima) 		PF00005
(ABC_tran) 		3 LYS A  72
ILE A  77
ILE A  82
 None
 0.59A 4y0qA-1ji0A:
undetectable		 4y0qA-1ji0A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k32 TRICORN PROTEASE

(Thermoplasma
acidophilum) 		PF03572
(Peptidase_S41)
PF07676
(PD40)
PF14684
(Tricorn_C1)
PF14685
(Tricorn_PDZ) 		3 LYS A 981
ILE A 983
ILE A1033
 None
 0.69A 4y0qA-1k32A:
undetectable		 4y0qA-1k32A:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l7y HYPOTHETICAL PROTEIN
ZK652.3

(Caenorhabditis
elegans) 		PF03671
(Ufm1) 		3 LYS A  29
ILE A  18
ILE A  59
 None
 0.70A 4y0qA-1l7yA:
undetectable		 4y0qA-1l7yA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lkd BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE

(Paraburkholderia
xenovorans) 		PF00903
(Glyoxalase) 		3 LYS A   2
ILE A 116
ILE A 104
 None
 0.61A 4y0qA-1lkdA:
undetectable		 4y0qA-1lkdA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nnw HYPOTHETICAL PROTEIN

(Pyrococcus
furiosus) 		no annotation 3 LYS A  72
ILE A  76
ILE A  90
 None
 0.68A 4y0qA-1nnwA:
undetectable		 4y0qA-1nnwA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nnx PROTEIN YGIW

(Escherichia
coli) 		PF04076
(BOF) 		3 LYS A 106
ILE A 104
ILE A  68
 None
 0.71A 4y0qA-1nnxA:
undetectable		 4y0qA-1nnxA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nvt SHIKIMATE
5'-DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		3 LYS A 129
ILE A 131
ILE A 198
 None
 0.59A 4y0qA-1nvtA:
undetectable		 4y0qA-1nvtA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o0s NAD-DEPENDENT MALIC
ENZYME

(Ascaris suum) 		PF00390
(malic)
PF03949
(Malic_M) 		3 LYS A 199
ILE A 195
ILE A 182
 None
 0.58A 4y0qA-1o0sA:
undetectable		 4y0qA-1o0sA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o70 FASCICLIN I

(Drosophila
melanogaster) 		PF02469
(Fasciclin) 		3 LYS A 593
ILE A 595
ILE A 612
 None
 0.69A 4y0qA-1o70A:
undetectable		 4y0qA-1o70A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1op2 VENOM SERINE
PROTEINASE

(Deinagkistrodon
acutus) 		PF00089
(Trypsin) 		3 LYS A 110
ILE A 112
ILE A 118
 None
 0.62A 4y0qA-1op2A:
undetectable		 4y0qA-1op2A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qs2 ADP-RIBOSYLTRANSFERA
SE

(Bacillus cereus) 		PF03496
(ADPrib_exo_Tox) 		3 LYS A 339
ILE A 341
ILE A 345
 None
 0.72A 4y0qA-1qs2A:
undetectable		 4y0qA-1qs2A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rki HYPOTHETICAL PROTEIN

(Pyrobaculum
aerophilum) 		PF11424
(DUF3195) 		3 LYS A   3
ILE A   5
ILE A  67
 None
 0.71A 4y0qA-1rkiA:
undetectable		 4y0qA-1rkiA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rqg METHIONYL-TRNA
SYNTHETASE

(Pyrococcus
abyssi) 		PF08264
(Anticodon_1)
PF09334
(tRNA-synt_1g) 		3 LYS A 279
ILE A 266
ILE A  99
 None
 0.66A 4y0qA-1rqgA:
undetectable		 4y0qA-1rqgA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rz0 PHENOL 2-HYDROXYLASE
COMPONENT B

(Parageobacillus
thermoglucosidasius) 		PF01613
(Flavin_Reduct) 		3 LYS A  64
ILE A  60
ILE A  50
 None
None
FAD  A1200 ( 4.9A)
 0.63A 4y0qA-1rz0A:
undetectable		 4y0qA-1rz0A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sy7 CATALASE 1

(Neurospora
crassa) 		PF00199
(Catalase)
PF01965
(DJ-1_PfpI)
PF06628
(Catalase-rel) 		3 LYS A 650
ILE A 620
ILE A 561
 None
 0.70A 4y0qA-1sy7A:
3.5		 4y0qA-1sy7A:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tff UBIQUITIN
THIOLESTERASE
PROTEIN OTUB2

(Homo sapiens) 		PF10275
(Peptidase_C65) 		3 LYS A  44
ILE A  42
ILE A  15
 None
 0.69A 4y0qA-1tffA:
undetectable		 4y0qA-1tffA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tkc TRANSKETOLASE

(Saccharomyces
cerevisiae) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		3 LYS A 668
ILE A 664
ILE A 581
 None
 0.73A 4y0qA-1tkcA:
undetectable		 4y0qA-1tkcA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u3i GLUTATHIONE
S-TRANSFERASE 28 KDA

(Schistosoma
mansoni) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		3 LYS A  57
ILE A   9
ILE A  36
 None
 0.68A 4y0qA-1u3iA:
undetectable		 4y0qA-1u3iA:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vra ARGININE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
ARGJ
ARGININE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
ARGJ

(Bacillus
halodurans;
Bacillus
halodurans) 		PF01960
(ArgJ)
PF01960
(ArgJ) 		3 LYS A 186
ILE B 278
ILE B 228
 SO4  A 197 (-2.7A)
None
None
 0.50A 4y0qA-1vraA:
undetectable		 4y0qA-1vraA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		3 LYS A 487
ILE A 523
ILE A 610
 None
 0.63A 4y0qA-1w99A:
undetectable		 4y0qA-1w99A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y4u CHAPERONE PROTEIN
HTPG

(Escherichia
coli) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		3 LYS A 212
ILE A 210
ILE A 197
 None
 0.69A 4y0qA-1y4uA:
undetectable		 4y0qA-1y4uA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z26 ARGONAUTE

(Pyrococcus
furiosus) 		PF02171
(Piwi)
PF12212
(PAZ_siRNAbind) 		3 LYS A 621
ILE A 623
ILE A 555
 None
 0.63A 4y0qA-1z26A:
undetectable		 4y0qA-1z26A:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7m ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT

(Lactococcus
lactis) 		PF13393
(tRNA-synt_His) 		3 LYS A 254
ILE A 256
ILE A 163
 None
 0.53A 4y0qA-1z7mA:
undetectable		 4y0qA-1z7mA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a98 INOSITOL
1,4,5-TRISPHOSPHATE
3-KINASE C

(Homo sapiens) 		PF03770
(IPK) 		3 LYS A 559
ILE A 557
ILE A 554
 None
 0.70A 4y0qA-2a98A:
undetectable		 4y0qA-2a98A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aw5 NADP-DEPENDENT MALIC
ENZYME

(Homo sapiens) 		PF00390
(malic)
PF03949
(Malic_M) 		3 LYS A 173
ILE A 169
ILE A 156
 None
 0.60A 4y0qA-2aw5A:
undetectable		 4y0qA-2aw5A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cwe HYPOTHETICAL
TRANSCRIPTION
REGULATOR PROTEIN,
PH1932

(Pyrococcus
horikoshii) 		PF01022
(HTH_5) 		3 LYS A  45
ILE A  50
ILE A  54
 None
 0.62A 4y0qA-2cweA:
undetectable		 4y0qA-2cweA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dgp BRUNO-LIKE 4, RNA
BINDING PROTEIN

(Homo sapiens) 		PF00076
(RRM_1) 		3 LYS A 119
ILE A 128
ILE A  58
 None
 0.67A 4y0qA-2dgpA:
undetectable		 4y0qA-2dgpA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fv4 HYPOTHETICAL 24.6
KDA PROTEIN IN
ILV2-ADE17
INTERGENIC REGION

(Saccharomyces
cerevisiae) 		PF08286
(Spc24) 		3 LYS B 203
ILE B 207
ILE B 181
 None
 0.73A 4y0qA-2fv4B:
undetectable		 4y0qA-2fv4B:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g6t UNCHARACTERIZED
PROTEIN, HOMOLOG
HI1244 FROM
HAEMOPHILUS
INFLUENZAE

(Clostridium
acetobutylicum) 		PF08942
(DUF1919) 		3 LYS A  87
ILE A  63
ILE A  35
 None
 0.70A 4y0qA-2g6tA:
undetectable		 4y0qA-2g6tA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gnp TRANSCRIPTIONAL
REGULATOR

(Streptococcus
pneumoniae) 		PF04198
(Sugar-bind) 		3 LYS A 310
ILE A 308
ILE A  79
 None
 0.66A 4y0qA-2gnpA:
undetectable		 4y0qA-2gnpA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i2q COFILIN

(Schizosaccharomyces
pombe) 		PF00241
(Cofilin_ADF) 		3 LYS A  80
ILE A  82
ILE A 117
 None
None
EDO  A 304 ( 4.9A)
 0.67A 4y0qA-2i2qA:
undetectable		 4y0qA-2i2qA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j87 THYMIDINE KINASE

(Vaccinia virus) 		PF00265
(TK) 		3 LYS A 102
ILE A  79
ILE A  38
 None
 0.71A 4y0qA-2j87A:
undetectable		 4y0qA-2j87A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jaq DEOXYGUANOSINE
KINASE

(Mycoplasma
mycoides) 		PF01712
(dNK) 		3 LYS A  73
ILE A   3
ILE A 127
 None
 0.60A 4y0qA-2jaqA:
undetectable		 4y0qA-2jaqA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lcj PAB POLC INTEIN

(Pyrococcus
abyssi) 		PF14890
(Intein_splicing) 		3 LYS A  42
ILE A  47
ILE A  12
 None
 0.63A 4y0qA-2lcjA:
undetectable		 4y0qA-2lcjA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ld4 ANAMORSIN

(Homo sapiens) 		PF08241
(Methyltransf_11) 		3 LYS A  56
ILE A  86
ILE A  63
 None
 0.66A 4y0qA-2ld4A:
undetectable		 4y0qA-2ld4A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n8n TRANSLATION
INITIATION FACTOR
IF-1

(Staphylococcus
aureus) 		PF01176
(eIF-1a) 		3 LYS A  39
ILE A  40
ILE A  47
 None
 0.73A 4y0qA-2n8nA:
undetectable		 4y0qA-2n8nA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nrq HYPOTHETICAL PROTEIN
ORF-C20_032

(Sulfolobus
solfataricus) 		PF01877
(RNA_binding) 		3 LYS A 101
ILE A 119
ILE A   8
 None
 0.69A 4y0qA-2nrqA:
undetectable		 4y0qA-2nrqA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nxg 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Aquifex
aeolicus) 		PF00793
(DAHP_synth_1) 		3 LYS A1041
ILE A1007
ILE A1180
 PEP  A1268 (-3.3A)
None
None
 0.57A 4y0qA-2nxgA:
undetectable		 4y0qA-2nxgA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ph5 HOMOSPERMIDINE
SYNTHASE

(Legionella
pneumophila) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		3 LYS A  64
ILE A  46
ILE A  77
 None
 0.72A 4y0qA-2ph5A:
undetectable		 4y0qA-2ph5A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyz UNCHARACTERIZED
PROTEIN

(Clostridium
tetani) 		PF09643
(YopX) 		3 LYS A  64
ILE A  66
ILE A  84
 None
 0.73A 4y0qA-2qyzA:
undetectable		 4y0qA-2qyzA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE

(Lactococcus
lactis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 LYS A 419
ILE A 416
ILE A  44
 LYS  A 419 ( 0.0A)
ILE  A 416 ( 0.7A)
ILE  A  44 ( 0.7A)
 0.73A 4y0qA-2vbfA:
undetectable		 4y0qA-2vbfA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8d PROCESSED GLYCEROL
PHOSPHATE
LIPOTEICHOIC ACID
SYNTHASE 2

(Bacillus
subtilis) 		PF00884
(Sulfatase) 		3 LYS A 245
ILE A 465
ILE A 507
 None
 0.54A 4y0qA-2w8dA:
undetectable		 4y0qA-2w8dA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wqp POLYSIALIC ACID
CAPSULE BIOSYNTHESIS
PROTEIN SIAC

(Neisseria
meningitidis) 		PF03102
(NeuB)
PF08666
(SAF) 		3 LYS A  53
ILE A  23
ILE A 232
 WQP  A1350 (-3.2A)
None
None
 0.73A 4y0qA-2wqpA:
undetectable		 4y0qA-2wqpA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		3 LYS A 103
ILE A  55
ILE A  21
 None
 0.70A 4y0qA-2wtbA:
undetectable		 4y0qA-2wtbA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x06 L-SULFOLACTATE
DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF02615
(Ldh_2) 		3 LYS A   1
ILE A 343
ILE A 339
 None
 0.67A 4y0qA-2x06A:
undetectable		 4y0qA-2x06A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xbi THIOREDOXIN

(Schistosoma
mansoni) 		PF00085
(Thioredoxin) 		3 LYS A  23
ILE A  54
ILE A   5
 None
 0.64A 4y0qA-2xbiA:
undetectable		 4y0qA-2xbiA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zkm 1-PHOSPHATIDYLINOSIT
OL-4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-2

(Homo sapiens) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		3 LYS X 461
ILE X 404
ILE X 323
 None
 0.58A 4y0qA-2zkmX:
undetectable		 4y0qA-2zkmX:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zyl POSSIBLE
OXIDOREDUCTASE

(Mycobacterium
tuberculosis) 		PF00355
(Rieske) 		3 LYS A 311
ILE A 307
ILE A 185
 None
 0.57A 4y0qA-2zylA:
2.1		 4y0qA-2zylA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3be8 NEUROLIGIN-4,
X-LINKED

(Homo sapiens) 		PF00135
(COesterase) 		3 LYS A 166
ILE A 197
ILE A 151
 None
 0.64A 4y0qA-3be8A:
1.6		 4y0qA-3be8A:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bmw CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE

(Thermoanaerobacterium
thermosulfurigenes) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		3 LYS A 648
ILE A 650
ILE A 657
 None
 0.67A 4y0qA-3bmwA:
undetectable		 4y0qA-3bmwA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwm CATECHOL
O-METHYLTRANSFERASE

(Homo sapiens) 		PF01596
(Methyltransf_3) 		3 LYS A   5
ILE A   9
ILE A  29
 None
 0.57A 4y0qA-3bwmA:
undetectable		 4y0qA-3bwmA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1

(Homo sapiens) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		3 LYS A 496
ILE A 500
ILE A 576
 None
 0.69A 4y0qA-3dwbA:
undetectable		 4y0qA-3dwbA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edn PHENAZINE
BIOSYNTHESIS
PROTEIN, PHZF FAMILY

(Bacillus
anthracis) 		PF02567
(PhzC-PhzF) 		3 LYS A  93
ILE A 109
ILE A 119
 None
 0.71A 4y0qA-3ednA:
undetectable		 4y0qA-3ednA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efe THIJ/PFPI FAMILY
PROTEIN

(Bacillus
anthracis) 		PF01965
(DJ-1_PfpI) 		3 LYS A  40
ILE A  42
ILE A  63
 None
 0.57A 4y0qA-3efeA:
undetectable		 4y0qA-3efeA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN

(Plexaura
homomalla) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		3 LYS A1002
ILE A1066
ILE A 796
 None
None
ACD  A2001 ( 4.9A)
 0.59A 4y0qA-3fg4A:
undetectable		 4y0qA-3fg4A:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fs2 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Brucella
melitensis) 		PF00793
(DAHP_synth_1) 		3 LYS A  57
ILE A  24
ILE A 197
 None
 0.53A 4y0qA-3fs2A:
undetectable		 4y0qA-3fs2A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gla LOW MOLECULAR WEIGHT
HEAT SHOCK PROTEIN

(Xanthomonas
citri) 		PF00011
(HSP20) 		3 LYS A  85
ILE A  64
ILE A  69
 None
 0.67A 4y0qA-3glaA:
undetectable		 4y0qA-3glaA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjz TRANSALDOLASE B

(Prochlorococcus
marinus) 		PF00923
(TAL_FSA) 		3 LYS A 123
ILE A 119
ILE A 154
 None
 0.70A 4y0qA-3hjzA:
undetectable		 4y0qA-3hjzA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipo PUTATIVE THIOSULFATE
SULFURTRANSFERASE
YNJE

(Escherichia
coli) 		PF00581
(Rhodanese) 		3 LYS A 169
ILE A 171
ILE A 192
 None
 0.61A 4y0qA-3ipoA:
undetectable		 4y0qA-3ipoA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jar MICROTUBULE-ASSOCIAT
ED PROTEIN RP/EB
FAMILY MEMBER 3

(Homo sapiens) 		no annotation 3 LYS N 112
ILE N 108
ILE N  35
 None
 0.64A 4y0qA-3jarN:
undetectable		 4y0qA-3jarN:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF11

(Schizosaccharomyces
pombe) 		PF13087
(AAA_12)
PF16399
(Aquarius_N) 		3 LYS X 581
ILE X 583
ILE X 559
 None
 0.68A 4y0qA-3jb9X:
undetectable		 4y0qA-3jb9X:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lfl GLUTATHIONE
S-TRANSFERASE
OMEGA-1

(Homo sapiens) 		PF13417
(GST_N_3)
PF14497
(GST_C_3) 		3 LYS A  45
ILE A  47
ILE A  24
 None
 0.68A 4y0qA-3lflA:
undetectable		 4y0qA-3lflA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lhf SERINE RECOMBINASE

(Sulfolobus
solfataricus) 		PF00239
(Resolvase) 		3 LYS A  55
ILE A  57
ILE A  89
 None
 0.72A 4y0qA-3lhfA:
undetectable		 4y0qA-3lhfA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lke ENOYL-COA HYDRATASE

(Bacillus
halodurans) 		PF00378
(ECH_1) 		3 LYS A 102
ILE A  52
ILE A  17
 None
 0.69A 4y0qA-3lkeA:
undetectable		 4y0qA-3lkeA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll7 PUTATIVE
METHYLTRANSFERASE

(Porphyromonas
gingivalis) 		no annotation 3 LYS A 315
ILE A 281
ILE A 279
 None
 0.69A 4y0qA-3ll7A:
undetectable		 4y0qA-3ll7A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpg DIHYDROOROTASE

(Bacillus
anthracis) 		PF01979
(Amidohydro_1) 		3 LYS A 341
ILE A 343
ILE A 290
 None
 0.67A 4y0qA-3mpgA:
undetectable		 4y0qA-3mpgA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mw8 UROPORPHYRINOGEN-III
SYNTHASE

(Shewanella
amazonensis) 		PF02602
(HEM4) 		3 LYS A 120
ILE A 122
ILE A  54
 None
 0.62A 4y0qA-3mw8A:
undetectable		 4y0qA-3mw8A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3njb ENOYL-COA HYDRATASE

(Mycolicibacterium
smegmatis) 		PF00378
(ECH_1) 		3 LYS A 137
ILE A  62
ILE A  27
 None
 0.55A 4y0qA-3njbA:
undetectable		 4y0qA-3njbA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o3w BH2092 PROTEIN

(Bacillus
halodurans) 		PF00581
(Rhodanese) 		3 LYS A  88
ILE A  50
ILE A  69
 None
 0.58A 4y0qA-3o3wA:
undetectable		 4y0qA-3o3wA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ome ENOYL-COA HYDRATASE

(Mycolicibacterium
smegmatis) 		PF00378
(ECH_1) 		3 LYS A  99
ILE A  49
ILE A  14
 None
 0.67A 4y0qA-3omeA:
undetectable		 4y0qA-3omeA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oon OUTER MEMBRANE
PROTEIN (TPN50)

(Borreliella
burgdorferi) 		PF00691
(OmpA) 		3 LYS A 300
ILE A 304
ILE A 384
 None
 0.64A 4y0qA-3oonA:
undetectable		 4y0qA-3oonA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q19 GLUTATHIONE
S-TRANSFERASE
OMEGA-2

(Homo sapiens) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		3 LYS A  45
ILE A  47
ILE A  24
 None
 0.70A 4y0qA-3q19A:
undetectable		 4y0qA-3q19A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qr1 PHOSPHOLIPASE C-BETA
(PLC-BETA)

(Doryteuthis
pealeii) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		3 LYS A 469
ILE A 413
ILE A 334
 None
 0.66A 4y0qA-3qr1A:
undetectable		 4y0qA-3qr1A:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qre ENOYL-COA HYDRATASE,
ECHA12_1

(Mycobacterium
marinum) 		PF00378
(ECH_1) 		3 LYS A 110
ILE A  57
ILE A  22
 None
 0.52A 4y0qA-3qreA:
undetectable		 4y0qA-3qreA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rsj BONT/F

(Clostridium
botulinum) 		PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N) 		3 LYS A1007
ILE A1009
ILE A1025
 None
 0.72A 4y0qA-3rsjA:
undetectable		 4y0qA-3rsjA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t0p DNA POLYMERASE III,
BETA SUBUNIT

([Eubacterium]
rectale) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		3 LYS A 313
ILE A 315
ILE A 317
 None
 0.68A 4y0qA-3t0pA:
undetectable		 4y0qA-3t0pA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t3w ENOYL-COA HYDRATASE

(Mycolicibacterium
thermoresistibile) 		PF00378
(ECH_1) 		3 LYS A 115
ILE A  65
ILE A  30
 None
 0.67A 4y0qA-3t3wA:
undetectable		 4y0qA-3t3wA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tov GLYCOSYL TRANSFERASE
FAMILY 9

(Veillonella
parvula) 		PF01075
(Glyco_transf_9) 		3 LYS A   6
ILE A   8
ILE A  91
 None
 0.69A 4y0qA-3tovA:
undetectable		 4y0qA-3tovA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1w HYPOTHETICAL
PERIPLASMIC PROTEIN

(Parabacteroides
distasonis) 		PF11396
(PepSY_like) 		3 LYS A 266
ILE A 268
ILE A 276
 None
 0.59A 4y0qA-3u1wA:
undetectable		 4y0qA-3u1wA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9l 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Sinorhizobium
meliloti) 		PF00106
(adh_short) 		3 LYS A   4
ILE A   6
ILE A  92
 None
 0.72A 4y0qA-3u9lA:
undetectable		 4y0qA-3u9lA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3upy OXIDOREDUCTASE

(Brucella
abortus) 		PF03447
(NAD_binding_3) 		3 LYS A 133
ILE A 111
ILE A  29
 None
 0.70A 4y0qA-3upyA:
undetectable		 4y0qA-3upyA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9e LACCASE

(Botrytis aclada) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 LYS A 225
ILE A 277
ILE A 251
 None
 0.67A 4y0qA-3v9eA:
undetectable		 4y0qA-3v9eA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vdr D-3-HYDROXYBUTYRATE
DEHYDROGENASE

(Alcaligenes
faecalis) 		PF00106
(adh_short) 		3 LYS A   5
ILE A  86
ILE A 138
 None
 0.72A 4y0qA-3vdrA:
undetectable		 4y0qA-3vdrA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vti HYDROGENASE
MATURATION FACTOR

(Caldanaerobacter
subterraneus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		3 LYS C 289
ILE C 186
ILE C 318
 None
 0.70A 4y0qA-3vtiC:
undetectable		 4y0qA-3vtiC:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wp5 CDBFV

(Neocallimastix
patriciarum) 		PF00457
(Glyco_hydro_11) 		3 LYS A  70
ILE A  75
ILE A 223
 None
 0.61A 4y0qA-3wp5A:
undetectable		 4y0qA-3wp5A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wrc GALLATE DIOXYGENASE

(Sphingomonas
paucimobilis) 		PF02900
(LigB)
PF07746
(LigA) 		3 LYS A   2
ILE A   4
ILE A 184
 None
 0.60A 4y0qA-3wrcA:
undetectable		 4y0qA-3wrcA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aka IL-4-INDUCING
PROTEIN

(Schistosoma
mansoni) 		no annotation 3 LYS A  44
ILE A 108
ILE A 105
 None
 0.61A 4y0qA-4akaA:
undetectable		 4y0qA-4akaA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ako SPORE COAT PROTEIN A

(Bacillus
subtilis) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 LYS A 249
ILE A 303
ILE A 276
 None
 0.70A 4y0qA-4akoA:
undetectable		 4y0qA-4akoA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c41 CORTICOSTEROID-BINDI
NG GLOBULIN

(Homo sapiens) 		PF00079
(Serpin) 		3 LYS A  39
ILE A  41
ILE A  43
 None
 0.56A 4y0qA-4c41A:
undetectable		 4y0qA-4c41A:
18.24