SIMILAR PATTERNS OF AMINO ACIDS FOR 4Y0Q_A_PX9A201_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5f MONOCLONAL
ANTI-E-SELECTIN 7A9
ANTIBODY (HEAVY
CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 LEU H 166
VAL H 188
ILE H 214
LEU H 145
VAL H 210
 None
 0.98A 4y0qA-1a5fH:
undetectable		 4y0qA-1a5fH:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a6t IGG1 FAB1-IA FAB
(HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 LEU B 159
VAL B 181
ILE B 210
LEU B 138
VAL B 206
 None
 1.12A 4y0qA-1a6tB:
undetectable		 4y0qA-1a6tB:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1axt IMMUNOGLOBULIN IGG2A

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 LEU H 166
VAL H 191
ILE H 223
LEU H 140
VAL H 219
 None
 1.05A 4y0qA-1axtH:
0.0		 4y0qA-1axtH:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cyg CYCLODEXTRIN
GLUCANOTRANSFERASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		5 LEU A 314
VAL A 313
ILE A 303
VAL A 344
LEU A 285
 None
 0.98A 4y0qA-1cygA:
0.0		 4y0qA-1cygA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fn4 MONOCLONAL ANTIBODY
AGAINST
ACETYLCHOLINE
RECEPTOR

(Rattus
norvegicus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 LEU B 152
VAL B 174
ILE B 203
LEU B 131
VAL B 199
 None
 1.11A 4y0qA-1fn4B:
0.0		 4y0qA-1fn4B:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8w LEUCOAGGLUTINATING
PHYTOHEMAGGLUTININ

(Phaseolus
vulgaris) 		PF00139
(Lectin_legB) 		5 LEU A 199
ILE A  57
LYS A   1
VAL A 193
LEU A 174
 None
 1.08A 4y0qA-1g8wA:
0.0		 4y0qA-1g8wA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ga8 GALACTOSYL
TRANSFERASE LGTC

(Neisseria
meningitidis) 		PF01501
(Glyco_transf_8) 		5 VAL A 108
LEU A  52
VAL A  35
LEU A  15
PHE A   5
 None
 0.97A 4y0qA-1ga8A:
0.0		 4y0qA-1ga8A:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hxn HEMOPEXIN

(Oryctolagus
cuniculus) 		PF00045
(Hemopexin) 		5 ILE A 293
LEU A 317
VAL A 239
LEU A 290
PHE A 284
 None
None
PO4  A   1 ( 4.2A)
None
None
 1.08A 4y0qA-1hxnA:
0.0		 4y0qA-1hxnA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hxn HEMOPEXIN

(Oryctolagus
cuniculus) 		PF00045
(Hemopexin) 		5 LEU A 355
ILE A 293
LEU A 317
LEU A 290
PHE A 284
 None
 1.12A 4y0qA-1hxnA:
0.0		 4y0qA-1hxnA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idm 3-ISOPROPYLMALATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00180
(Iso_dh) 		6 LEU A  32
LEU A 290
LYS A   1
GLU A  65
VAL A 309
VAL A 338
 None
 1.42A 4y0qA-1idmA:
0.0		 4y0qA-1idmA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1igy IGG1 INTACT ANTIBODY
MAB61.1.3

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 LEU B 166
VAL B 191
ILE B 223
LEU B 140
VAL B 219
 None
 0.98A 4y0qA-1igyB:
undetectable		 4y0qA-1igyB:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1izo CYTOCHROME P450
152A1

(Bacillus
subtilis) 		PF00067
(p450) 		5 LEU A 102
VAL A 240
ILE A 194
LEU A 241
MET A 217
 None
HEM  A 501 (-4.5A)
None
None
None
 1.10A 4y0qA-1izoA:
undetectable		 4y0qA-1izoA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jwq N-ACETYLMURAMOYL-L-A
LANINE AMIDASE CWLV

(Paenibacillus
polymyxa) 		PF01520
(Amidase_3) 		5 VAL A 139
ILE A 168
LEU A 141
VAL A  49
LEU A  51
 None
 1.12A 4y0qA-1jwqA:
undetectable		 4y0qA-1jwqA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l8r DACHSHUND

(Homo sapiens) 		PF02437
(Ski_Sno) 		6 LEU A 219
VAL A 229
LEU A 208
ILE A 267
LEU A 233
LYS A 232
 None
 1.30A 4y0qA-1l8rA:
undetectable		 4y0qA-1l8rA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m7t CHIMERA OF HUMAN AND
E. COLI THIOREDOXIN

(Escherichia
coli;
Homo sapiens) 		PF00085
(Thioredoxin) 		5 LEU A  78
VAL A  25
ILE A   5
LEU A  55
VAL A  65
 None
 1.13A 4y0qA-1m7tA:
undetectable		 4y0qA-1m7tA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mky PROBABLE GTP-BINDING
PROTEIN ENGA

(Thermotoga
maritima) 		PF01926
(MMR_HSR1)
PF14714
(KH_dom-like) 		5 LEU A  53
VAL A   4
ILE A 114
LEU A  84
VAL A  89
 None
 1.06A 4y0qA-1mkyA:
undetectable		 4y0qA-1mkyA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1obg PHOSPHORIBOSYLAMIDOI
MIDAZOLE-
SUCCINOCARBOXAMIDE
SYNTHASE

(Saccharomyces
cerevisiae) 		PF01259
(SAICAR_synt) 		6 LEU A 182
VAL A 183
LEU A 187
VAL A 119
VAL A 121
PHE A 159
 None
 1.36A 4y0qA-1obgA:
undetectable		 4y0qA-1obgA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qo0 AMIR

(Pseudomonas
aeruginosa) 		PF03861
(ANTAR) 		5 ILE D  35
LEU D 116
VAL D  15
VAL D  17
PHE D  57
 None
 0.92A 4y0qA-1qo0D:
undetectable		 4y0qA-1qo0D:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r3d CONSERVED
HYPOTHETICAL PROTEIN
VC1974

(Vibrio cholerae) 		PF12697
(Abhydrolase_6) 		5 ILE A  71
LEU A  96
VAL A  19
VAL A  85
LEU A 111
 None
 1.01A 4y0qA-1r3dA:
undetectable		 4y0qA-1r3dA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sa3 TYPE II RESTRICTION
ENZYME MSPI

(Moraxella sp.) 		PF09208
(Endonuc-MspI) 		5 LEU A 147
ILE A 151
LYS A 257
VAL A 140
PHE A 182
 None
 1.08A 4y0qA-1sa3A:
undetectable		 4y0qA-1sa3A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tht THIOESTERASE

(Vibrio harveyi) 		PF02273
(Acyl_transf_2) 		5 VAL A 138
LEU A 165
VAL A 178
LEU A 154
MET A  86
 None
 0.98A 4y0qA-1thtA:
undetectable		 4y0qA-1thtA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1to6 GLYCERATE KINASE

(Neisseria
meningitidis) 		PF02595
(Gly_kinase) 		5 LEU A 119
ILE A 143
LEU A 147
VAL A  88
VAL A  92
 None
 1.00A 4y0qA-1to6A:
undetectable		 4y0qA-1to6A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2v ACTIN-RELATED
PROTEIN 3

(Bos taurus) 		PF00022
(Actin) 		5 LEU A 139
VAL A 136
ILE A  97
GLU A 132
VAL A  10
 None
 1.14A 4y0qA-1u2vA:
undetectable		 4y0qA-1u2vA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6g TIP120 PROTEIN

(Homo sapiens) 		PF08623
(TIP120) 		5 VAL C  79
LEU C  91
ILE C  87
LYS C  80
VAL C  69
 None
 1.13A 4y0qA-1u6gC:
undetectable		 4y0qA-1u6gC:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uok OLIGO-1,6-GLUCOSIDAS
E

(Bacillus cereus) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		5 LEU A  95
ILE A  48
LEU A  40
VAL A  53
LEU A  30
 None
 1.12A 4y0qA-1uokA:
1.6		 4y0qA-1uokA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE

(Thermus
thermophilus) 		PF01070
(FMN_dh) 		5 LEU A 138
LEU A 204
VAL A 184
VAL A 186
LEU A 126
 None
 1.10A 4y0qA-1vcgA:
undetectable		 4y0qA-1vcgA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE

(Thermus
thermophilus) 		PF01070
(FMN_dh) 		5 LEU A 204
VAL A 184
VAL A 186
LEU A 126
PHE A 151
 None
 0.92A 4y0qA-1vcgA:
undetectable		 4y0qA-1vcgA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w25 STALKED-CELL
DIFFERENTIATION
CONTROLLING PROTEIN

(Caulobacter
vibrioides) 		PF00072
(Response_reg)
PF00990
(GGDEF) 		5 VAL A 374
ILE A 415
LEU A 324
VAL A 395
PHE A 350
 None
 0.99A 4y0qA-1w25A:
undetectable		 4y0qA-1w25A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1woq INORGANIC
POLYPHOSPHATE/ATP-GL
UCOMANNOKINASE

(Arthrobacter
sp. KM) 		PF00480
(ROK) 		5 LEU A 212
LEU A 149
ILE A 147
LEU A 145
LEU A 235
 None
 1.03A 4y0qA-1woqA:
undetectable		 4y0qA-1woqA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wx8 RIKEN CDNA
4931431F19

(Mus musculus) 		PF00240
(ubiquitin) 		5 LEU A  59
VAL A  22
VAL A  20
LEU A  33
PHE A  31
 None
 0.96A 4y0qA-1wx8A:
undetectable		 4y0qA-1wx8A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yee IGG2A FAB FRAGMENT
(D2.5)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 LEU H 164
VAL H 189
ILE H 221
LEU H 138
VAL H 217
 None
 1.10A 4y0qA-1yeeH:
undetectable		 4y0qA-1yeeH:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z05 TRANSCRIPTIONAL
REGULATOR, ROK
FAMILY

(Vibrio cholerae) 		PF00480
(ROK) 		5 LEU A 128
ILE A  98
GLU A 117
VAL A 145
LEU A 142
 None
 1.10A 4y0qA-1z05A:
undetectable		 4y0qA-1z05A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zsq MYOTUBULARIN-RELATED
PROTEIN 2

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		6 LEU A 433
VAL A 487
LEU A 540
ILE A 508
LEU A 505
VAL A 449
 None
 1.44A 4y0qA-1zsqA:
undetectable		 4y0qA-1zsqA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2avt DNA POLYMERASE III
BETA SUBUNIT

(Streptococcus
pyogenes) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		5 LEU A  45
LEU A  89
ILE A  94
LEU A 115
PHE A  82
 None
 1.13A 4y0qA-2avtA:
undetectable		 4y0qA-2avtA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3t FATTY OXIDATION
COMPLEX ALPHA
SUBUNIT

(Pseudomonas
fragi) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 LEU A 672
LEU A 635
VAL A 680
LEU A 703
PHE A 683
 None
 1.06A 4y0qA-2d3tA:
undetectable		 4y0qA-2d3tA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dh3 4F2 CELL-SURFACE
ANTIGEN HEAVY CHAIN

(Homo sapiens) 		PF00128
(Alpha-amylase) 		5 LEU A 153
VAL A 155
LEU A 129
ILE A 126
LEU A 192
 None
 1.13A 4y0qA-2dh3A:
undetectable		 4y0qA-2dh3A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpw HYPOTHETICAL PROTEIN
TTHA0179

(Thermus
thermophilus) 		PF12804
(NTP_transf_3) 		5 LEU A  66
VAL A  52
LEU A   8
VAL A  83
LEU A  47
 None
 1.00A 4y0qA-2dpwA:
undetectable		 4y0qA-2dpwA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fml MUTT/NUDIX FAMILY
PROTEIN

(Enterococcus
faecalis) 		PF00293
(NUDIX) 		5 VAL A  58
LEU A 171
ILE A 158
LEU A 160
VAL A 198
 None
 1.13A 4y0qA-2fmlA:
undetectable		 4y0qA-2fmlA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gju 252AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii) 		no annotation 6 LEU A 118
LEU A   7
ILE A  10
VAL A  68
VAL A  66
LEU A  60
 None
 1.35A 4y0qA-2gjuA:
undetectable		 4y0qA-2gjuA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gpr GLUCOSE-PERMEASE IIA
COMPONENT

(Mycoplasma
capricolum) 		PF00358
(PTS_EIIA_1) 		5 VAL A 120
LEU A  82
ILE A  84
LYS A 123
VAL A 113
 None
 1.10A 4y0qA-2gprA:
undetectable		 4y0qA-2gprA:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gzm GLUTAMATE RACEMASE

(Bacillus
anthracis) 		PF01177
(Asp_Glu_race) 		5 LEU A 143
VAL A 198
VAL A 194
LEU A 191
MET A 199
 None
 0.99A 4y0qA-2gzmA:
undetectable		 4y0qA-2gzmA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h0e TRANSTHYRETIN-LIKE
PROTEIN PUCM

(Bacillus
subtilis) 		PF00576
(Transthyretin) 		5 VAL A  93
VAL A  91
LEU A 110
PHE A  69
MET A  67
 None
 1.11A 4y0qA-2h0eA:
undetectable		 4y0qA-2h0eA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hiv THERMOSTABLE DNA
LIGASE

(Sulfolobus
solfataricus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		5 VAL A 229
LEU A 349
ILE A 307
VAL A 296
VAL A 292
 None
 1.13A 4y0qA-2hivA:
undetectable		 4y0qA-2hivA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		5 LEU A 534
LEU A 511
ILE A 615
VAL A 552
VAL A 554
 None
 0.87A 4y0qA-2j0jA:
undetectable		 4y0qA-2j0jA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		5 LEU A 534
LEU A 511
ILE A 615
VAL A 552
VAL A 554
 None
 0.82A 4y0qA-2jkmA:
undetectable		 4y0qA-2jkmA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k5e UNCHARACTERIZED
PROTEIN

(Methanocaldococcus
jannaschii) 		PF08984
(DUF1858) 		5 LEU A  15
VAL A  21
LEU A  52
ILE A  57
LEU A  61
 None
 1.09A 4y0qA-2k5eA:
undetectable		 4y0qA-2k5eA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oz4 FAB FRAGMENT, HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 LEU H 160
VAL H 182
ILE H 211
LEU H 139
VAL H 207
 None
 1.11A 4y0qA-2oz4H:
undetectable		 4y0qA-2oz4H:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oze ORF DELTA'

(Streptococcus
pyogenes) 		PF13614
(AAA_31) 		5 LEU A  66
VAL A  68
ILE A  39
VAL A 282
LEU A  53
 None
 0.99A 4y0qA-2ozeA:
undetectable		 4y0qA-2ozeA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1n TRANSPORT INHIBITOR
RESPONSE 1 PROTEIN

(Arabidopsis
thaliana) 		PF12937
(F-box-like) 		5 LEU B 218
ILE B 191
LEU B 163
VAL B 207
LEU B 213
 None
 1.13A 4y0qA-2p1nB:
undetectable		 4y0qA-2p1nB:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3e DIAMINOPIMELATE
DECARBOXYLASE

(Aquifex
aeolicus) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 LEU A  18
GLU A   2
VAL A 396
VAL A 394
LEU A  36
 None
 1.11A 4y0qA-2p3eA:
undetectable		 4y0qA-2p3eA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pd2 HYPOTHETICAL PROTEIN
ST0148

(Sulfurisphaera
tokodaii) 		PF02635
(DrsE) 		5 VAL A   4
LEU A  44
GLU A 101
VAL A  13
LEU A  17
 None
 0.99A 4y0qA-2pd2A:
undetectable		 4y0qA-2pd2A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qw6 AAA ATPASE, CENTRAL
REGION

(Enterococcus
faecium) 		PF12002
(MgsA_C)
PF16193
(AAA_assoc_2) 		5 LEU A 317
VAL A 320
ILE A 282
LEU A 324
PHE A 247
 None
 1.11A 4y0qA-2qw6A:
undetectable		 4y0qA-2qw6A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qza SECRETED EFFECTOR
PROTEIN

(Salmonella
enterica) 		PF13599
(Pentapeptide_4)
PF13979
(SopA_C)
PF13981
(SopA) 		5 VAL A 402
LEU A 331
ILE A 356
LEU A 357
LEU A 301
 None
 1.11A 4y0qA-2qzaA:
undetectable		 4y0qA-2qzaA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ro1 TRANSCRIPTION
INTERMEDIARY FACTOR
1-BETA

(Homo sapiens) 		PF00628
(PHD) 		5 LEU A 740
ILE A 743
LEU A 788
PHE A 792
MET A 796
 None
 1.13A 4y0qA-2ro1A:
undetectable		 4y0qA-2ro1A:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vvt GLUTAMATE RACEMASE

(Enterococcus
faecalis) 		PF01177
(Asp_Glu_race) 		5 LEU A 143
VAL A 198
VAL A 194
LEU A 191
MET A 199
 None
 0.98A 4y0qA-2vvtA:
undetectable		 4y0qA-2vvtA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR

(Methanothermobacter
thermautotrophicus) 		PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		5 LEU A 424
VAL A 427
ILE A 432
VAL A 442
PHE A 483
 None
 1.13A 4y0qA-2ycbA:
1.6		 4y0qA-2ycbA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR

(Methanothermobacter
thermautotrophicus) 		PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		5 LEU A 504
VAL A 442
ILE A 401
GLU A 429
VAL A 531
 None
 1.13A 4y0qA-2ycbA:
1.6		 4y0qA-2ycbA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ygn WNT INHIBITORY
FACTOR 1

(Homo sapiens) 		PF02019
(WIF) 		5 LEU A  48
VAL A 136
VAL A 134
PHE A  89
MET A  87
 PCF  A1179 (-4.1A)
None
PCF  A1179 ( 4.7A)
PCF  A1179 ( 3.8A)
PCF  A1179 (-3.6A)
 1.11A 4y0qA-2ygnA:
undetectable		 4y0qA-2ygnA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ygo WNT INHIBITORY
FACTOR 1

(Homo sapiens) 		PF02019
(WIF) 		5 LEU A  48
VAL A 136
VAL A 134
PHE A  89
MET A  87
 PCF  A1213 (-4.3A)
None
PCF  A1213 ( 4.6A)
PCF  A1213 (-4.1A)
PCF  A1213 ( 3.8A)
 1.13A 4y0qA-2ygoA:
undetectable		 4y0qA-2ygoA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus) 		PF08241
(Methyltransf_11) 		5 VAL A  91
ILE A  98
VAL A 108
VAL A 110
LEU A 113
 None
 1.13A 4y0qA-2yr0A:
undetectable		 4y0qA-2yr0A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ze4 PHOSPHOLIPASE D

(Streptomyces
antibioticus) 		PF13091
(PLDc_2) 		5 ILE A 325
LEU A 324
GLU A 473
VAL A 367
LEU A 339
 None
 1.07A 4y0qA-2ze4A:
undetectable		 4y0qA-2ze4A:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a8p T-LYMPHOMA INVASION
AND
METASTASIS-INDUCING
PROTEIN 2

(Mus musculus) 		PF00169
(PH) 		5 LEU A 566
LEU A 540
VAL A 573
LEU A 606
PHE A 586
 None
 1.13A 4y0qA-3a8pA:
undetectable		 4y0qA-3a8pA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai9 UPF0217 PROTEIN
MJ1640

(Methanocaldococcus
jannaschii) 		PF04013
(Methyltrn_RNA_2) 		5 LEU X  56
LEU X  73
ILE X 112
GLU X  95
VAL X  36
 None
 1.11A 4y0qA-3ai9X:
undetectable		 4y0qA-3ai9X:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aup BASIC 7S GLOBULIN

(Glycine max) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		5 LEU A 273
VAL A 348
ILE A 330
LEU A 335
LEU A 366
 None
 1.06A 4y0qA-3aupA:
undetectable		 4y0qA-3aupA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3awk CHALCONE
SYNTHASE-LIKE
POLYKETIDE SYNTHASE

(Huperzia
serrata) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 LEU A 356
VAL A 352
LEU A 293
ILE A 381
LEU A 329
 None
 1.14A 4y0qA-3awkA:
undetectable		 4y0qA-3awkA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bcq ALPHA-CHAIN
HEMOGLOBIN

(Brycon cephalus) 		PF00042
(Globin) 		6 LEU A  92
VAL A  94
LEU A 106
VAL A  63
VAL A  67
LEU A 133
 HEM  A 143 (-4.1A)
HEM  A 143 (-4.5A)
None
HEM  A 143 (-4.3A)
None
HEM  A 143 (-4.9A)
 1.19A 4y0qA-3bcqA:
undetectable		 4y0qA-3bcqA:
28.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqu 3H6 FAB HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 LEU D 170
VAL D 192
ILE D 221
LEU D 149
VAL D 217
 None
 1.07A 4y0qA-3bquD:
undetectable		 4y0qA-3bquD:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cnn PUTATIVE
UNCHARACTERIZED
PROTEIN

(Thermotoga
maritima) 		PF01926
(MMR_HSR1) 		5 LEU A  18
VAL A  22
LEU A 119
ILE A 148
LEU A  52
 None
 1.12A 4y0qA-3cnnA:
undetectable		 4y0qA-3cnnA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddj CBS
DOMAIN-CONTAINING
PROTEIN

(Sulfolobus
solfataricus) 		PF00571
(CBS) 		5 ILE A  36
LYS A  16
GLU A  17
VAL A 111
VAL A  87
 None
 1.03A 4y0qA-3ddjA:
undetectable		 4y0qA-3ddjA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1s EXODEOXYRIBONUCLEASE
V, SUBUNIT RECD

(Deinococcus
radiodurans) 		PF13538
(UvrD_C_2)
PF13604
(AAA_30)
PF14490
(HHH_4) 		5 LEU A 347
VAL A 346
LEU A 397
LEU A 358
GLU A 342
 None
 0.98A 4y0qA-3e1sA:
undetectable		 4y0qA-3e1sA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		5 LEU A1111
VAL A1191
VAL A1119
VAL A1121
LEU A1195
 None
 0.99A 4y0qA-3ecqA:
undetectable		 4y0qA-3ecqA:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efs BIOTIN
[ACETYL-COA-CARBOXYL
ASE] LIGASE

(Aquifex
aeolicus) 		PF02237
(BPL_C)
PF03099
(BPL_LplA_LipB) 		5 ILE A 161
LEU A 165
GLU A  62
VAL A 107
VAL A  97
 None
 0.94A 4y0qA-3efsA:
undetectable		 4y0qA-3efsA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f83 FUSION OF THE MINOR
PILIN CFAE AND MAJOR
PILIN CFAB

(Escherichia
coli) 		PF04449
(Fimbrial_CS1)
PF07434
(CblD) 		5 LEU A 381
VAL A 424
VAL A 422
LEU A 465
PHE A 460
 None
 0.84A 4y0qA-3f83A:
undetectable		 4y0qA-3f83A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f84 CFA/I FIMBRIAL
SUBUNIT B

(Escherichia
coli) 		PF04449
(Fimbrial_CS1) 		5 LEU A   4
VAL A  47
VAL A  45
LEU A  88
PHE A  83
 None
 0.93A 4y0qA-3f84A:
undetectable		 4y0qA-3f84A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f85 HOMO TRIMERIC FUSION
OF CFA/I FIMBRIAL
SUBUNITS B

(Escherichia
coli) 		PF04449
(Fimbrial_CS1) 		5 LEU A   4
VAL A  47
VAL A  45
LEU A  88
PHE A  83
 None
 0.84A 4y0qA-3f85A:
undetectable		 4y0qA-3f85A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f85 HOMO TRIMERIC FUSION
OF CFA/I FIMBRIAL
SUBUNITS B

(Escherichia
coli) 		PF04449
(Fimbrial_CS1) 		5 LEU A 155
VAL A 198
VAL A 196
LEU A 239
PHE A 234
 None
 0.84A 4y0qA-3f85A:
undetectable		 4y0qA-3f85A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f85 HOMO TRIMERIC FUSION
OF CFA/I FIMBRIAL
SUBUNITS B

(Escherichia
coli) 		PF04449
(Fimbrial_CS1) 		5 LEU A 306
VAL A 349
VAL A 347
LEU A 390
PHE A 385
 None
 0.79A 4y0qA-3f85A:
undetectable		 4y0qA-3f85A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fbk REGULATOR OF
G-PROTEIN SIGNALING
3

(Homo sapiens) 		PF00168
(C2) 		5 LEU A  50
VAL A 116
LEU A 141
PHE A 136
MET A 134
 None
 1.07A 4y0qA-3fbkA:
undetectable		 4y0qA-3fbkA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8) 		5 LEU A 230
VAL A 233
LEU A 415
VAL A 312
VAL A 310
 None
 0.95A 4y0qA-3gcwA:
undetectable		 4y0qA-3gcwA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 SMALL NUCLEAR
RIBONUCLEOPROTEIN SM
D2
SMALL NUCLEAR
RIBONUCLEOPROTEIN F

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		PF01423
(LSM)
PF01423
(LSM) 		5 LEU I  60
VAL G 110
ILE I  65
VAL I  20
LEU I  34
 None
 1.11A 4y0qA-3jb9I:
undetectable		 4y0qA-3jb9I:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kb6 D-LACTATE
DEHYDROGENASE

(Aquifex
aeolicus) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 LEU A  67
ILE A  78
VAL A  48
VAL A  32
LEU A  58
 None
None
None
None
1PE  A 700 (-4.4A)
 1.07A 4y0qA-3kb6A:
undetectable		 4y0qA-3kb6A:
19.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kza BETA-LACTOGLOBULIN

(Equus caballus;
Bos taurus) 		PF00061
(Lipocalin) 		7 LEU A  39
VAL A  41
LEU A  54
ILE A  56
LEU A  58
LYS A  60
MET A 107
 None
 1.05A 4y0qA-3kzaA:
25.2		 4y0qA-3kzaA:
81.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kza BETA-LACTOGLOBULIN

(Equus caballus;
Bos taurus) 		PF00061
(Lipocalin) 		7 LEU A  39
VAL A  41
LEU A  54
ILE A  56
LEU A  58
VAL A  92
MET A 107
 None
 0.80A 4y0qA-3kzaA:
25.2		 4y0qA-3kzaA:
81.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kza BETA-LACTOGLOBULIN

(Equus caballus;
Bos taurus) 		PF00061
(Lipocalin) 		9 LEU A  39
VAL A  41
LEU A  54
ILE A  56
LYS A  60
VAL A  94
LEU A 103
PHE A 105
MET A 107
 None
 0.85A 4y0qA-3kzaA:
25.2		 4y0qA-3kzaA:
81.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kza BETA-LACTOGLOBULIN

(Equus caballus;
Bos taurus) 		PF00061
(Lipocalin) 		9 LEU A  39
VAL A  41
LEU A  54
ILE A  56
VAL A  92
VAL A  94
LEU A 103
PHE A 105
MET A 107
 None
 0.56A 4y0qA-3kzaA:
25.2		 4y0qA-3kzaA:
81.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kza BETA-LACTOGLOBULIN

(Equus caballus;
Bos taurus) 		PF00061
(Lipocalin) 		6 LEU A  87
VAL A  92
VAL A  94
LEU A 103
PHE A 105
MET A 107
 None
 1.31A 4y0qA-3kzaA:
25.2		 4y0qA-3kzaA:
81.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la6 TYROSINE-PROTEIN
KINASE WZC

(Escherichia
coli) 		PF13614
(AAA_31) 		5 LEU A 680
LEU A 513
ILE A 694
GLU A 675
LEU A 529
 None
 1.12A 4y0qA-3la6A:
undetectable		 4y0qA-3la6A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nbh RECQ-MEDIATED GENOME
INSTABILITY PROTEIN
2

(Homo sapiens) 		PF16100
(RMI2) 		5 LEU B  30
LEU B  86
VAL B 104
VAL B 102
MET B  60
 None
 1.00A 4y0qA-3nbhB:
undetectable		 4y0qA-3nbhB:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nmz APC VARIANT PROTEIN

(Homo sapiens) 		PF00514
(Arm) 		5 LEU A 563
VAL A 566
LEU A 479
VAL A 547
VAL A 543
 None
 1.10A 4y0qA-3nmzA:
undetectable		 4y0qA-3nmzA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nva CTP SYNTHASE

(Sulfolobus
solfataricus) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		5 LEU A 266
LEU A  21
ILE A  25
LEU A  29
VAL A 174
 None
 1.00A 4y0qA-3nvaA:
undetectable		 4y0qA-3nvaA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o80 HEXOKINASE

(Kluyveromyces
lactis) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 LEU A 170
ILE A 130
GLU A 180
LEU A 152
PHE A 154
 None
 1.12A 4y0qA-3o80A:
undetectable		 4y0qA-3o80A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdi NITROGENASE MOFE
COFACTOR
BIOSYNTHESIS PROTEIN
NIFE

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro) 		5 ILE A 398
LEU A 415
GLU A 433
VAL A 350
MET A 348
 None
 1.11A 4y0qA-3pdiA:
undetectable		 4y0qA-3pdiA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pg6 E3 UBIQUITIN-PROTEIN
LIGASE DTX3L

(Homo sapiens) 		no annotation 5 LEU A 727
VAL A 673
ILE A 635
LEU A 677
GLU A 733
 None
 1.12A 4y0qA-3pg6A:
undetectable		 4y0qA-3pg6A:
18.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ph5 BETA-LACTOGLOBULIN

(Bos taurus) 		PF00061
(Lipocalin) 		6 LEU A  55
VAL A  57
ILE A  87
LEU A  74
VAL A 108
PHE A 121
 None
 1.44A 4y0qA-3ph5A:
28.7		 4y0qA-3ph5A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ph5 BETA-LACTOGLOBULIN

(Bos taurus) 		PF00061
(Lipocalin) 		12 LEU A  55
VAL A  57
LEU A  70
ILE A  72
LEU A  74
LYS A  76
GLU A  78
VAL A 108
VAL A 110
LEU A 119
PHE A 121
MET A 123
 None
 0.73A 4y0qA-3ph5A:
28.7		 4y0qA-3ph5A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q2v CADHERIN-1

(Mus musculus) 		PF00028
(Cadherin) 		5 ILE A 511
VAL A 529
VAL A 531
PHE A 448
MET A 446
 None
 1.03A 4y0qA-3q2vA:
undetectable		 4y0qA-3q2vA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qy9 DIHYDRODIPICOLINATE
REDUCTASE

(Staphylococcus
aureus) 		PF01113
(DapB_N)
PF05173
(DapB_C) 		5 VAL A  49
LEU A  64
ILE A   6
LEU A   4
LEU A  94
 None
 1.11A 4y0qA-3qy9A:
undetectable		 4y0qA-3qy9A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swg UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Aquifex
aeolicus) 		PF00275
(EPSP_synthase) 		5 LEU A 179
LEU A 195
ILE A 193
LEU A 190
VAL A 199
 None
 1.12A 4y0qA-3swgA:
undetectable		 4y0qA-3swgA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tlz MCCF

(Escherichia
coli) 		PF02016
(Peptidase_S66) 		5 VAL A 264
LEU A 273
ILE A 271
LYS A 267
VAL A 252
 None
EDO  A 347 ( 4.3A)
None
EDO  A 346 ( 3.7A)
EDO  A 347 ( 4.9A)
 1.09A 4y0qA-3tlzA:
undetectable		 4y0qA-3tlzA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tx2 PROBABLE
6-PHOSPHOGLUCONOLACT
ONASE

(Mycobacteroides
abscessus) 		PF01182
(Glucosamine_iso) 		5 LEU A  61
GLU A 133
VAL A  96
LEU A  92
PHE A  98
 None
 1.11A 4y0qA-3tx2A:
undetectable		 4y0qA-3tx2A:
20.39