SIMILAR PATTERNS OF AMINO ACIDS FOR 4Y0P_A_TE4A201_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj0 PSEUDOURIDINE
SYNTHASE I

(Escherichia
coli) 		PF01416
(PseudoU_synth_1) 		5 ILE A 207
ILE A 194
VAL A 192
VAL A 190
LEU A 143
 None
 1.22A 4y0pA-1dj0A:
0.5		 4y0pA-1dj0A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dms DMSO REDUCTASE

(Rhodobacter
capsulatus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		5 LEU A 174
VAL A 217
VAL A 219
PHE A 183
MET A 181
 None
 1.15A 4y0pA-1dmsA:
0.0		 4y0pA-1dmsA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fyh INTERFERON GAMMA
RECEPTOR 1

(Homo sapiens) 		PF01108
(Tissue_fac)
PF07140
(IFNGR1) 		5 LEU B 185
ILE B 187
ILE B 124
ILE B 117
VAL B 198
 None
 0.80A 4y0pA-1fyhB:
0.4		 4y0pA-1fyhB:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkw DIAMINOPIMELATE
DECARBOXYLASE

(Mycobacterium
tuberculosis) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 LEU A 297
LEU A 234
ILE A 232
VAL A 160
LEU A 207
 None
 0.92A 4y0pA-1hkwA:
undetectable		 4y0pA-1hkwA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i5a CHEMOTAXIS PROTEIN
CHEA

(Thermotoga
maritima) 		PF02518
(HATPase_c) 		5 LEU A 406
ILE A 454
VAL A 488
PHE A 487
MET A 507
 None
ACP  A 998 (-4.3A)
None
None
ACP  A 998 (-3.7A)
 1.15A 4y0pA-1i5aA:
0.0		 4y0pA-1i5aA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i5a CHEMOTAXIS PROTEIN
CHEA

(Thermotoga
maritima) 		PF02518
(HATPase_c) 		5 VAL A 533
ILE A 454
VAL A 488
PHE A 487
MET A 507
 None
ACP  A 998 (-4.3A)
None
None
ACP  A 998 (-3.7A)
 0.96A 4y0pA-1i5aA:
0.0		 4y0pA-1i5aA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kc8 RIBOSOMAL PROTEIN
L15E

(Haloarcula
marismortui) 		PF00827
(Ribosomal_L15e) 		5 ILE N 100
ILE N  67
VAL N  65
VAL N  63
LEU N 133
 A  A1470 ( 4.1A)
None
None
None
None
 1.01A 4y0pA-1kc8N:
undetectable		 4y0pA-1kc8N:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT

(Acidaminococcus
fermentans) 		PF01039
(Carboxyl_trans) 		5 ILE A 411
ILE A 449
ILE A 547
LEU A 335
PHE A 330
 None
 1.08A 4y0pA-1pixA:
1.7		 4y0pA-1pixA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z82 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Thermotoga
maritima) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		5 LEU A 189
ILE A 182
ILE A 290
VAL A 294
VAL A 298
 MRD  A 601 (-4.2A)
None
None
MRD  A 601 (-4.2A)
None
 0.92A 4y0pA-1z82A:
undetectable		 4y0pA-1z82A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cg4 REGULATORY PROTEIN
ASNC

(Escherichia
coli) 		PF01037
(AsnC_trans_reg)
PF13404
(HTH_AsnC-type) 		5 LEU A  92
VAL A  95
ILE A 107
ILE A  74
ILE A 133
 None
 0.82A 4y0pA-2cg4A:
0.5		 4y0pA-2cg4A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2crq MITOCHONDRIAL
TRANSLATIONAL
INITIATION FACTOR 3

(Mus musculus) 		PF00707
(IF3_C) 		5 ILE A  66
ILE A  50
VAL A  48
VAL A  46
PHE A  97
 None
 1.04A 4y0pA-2crqA:
undetectable		 4y0pA-2crqA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ddt SPHINGOMYELIN
PHOSPHODIESTERASE

(Bacillus cereus) 		PF03372
(Exo_endo_phos) 		5 LEU A  64
VAL A 106
ILE A  43
ILE A  37
VAL A  17
 None
 1.08A 4y0pA-2ddtA:
1.6		 4y0pA-2ddtA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgv TAGATOSE-6-PHOSPHATE
KINASE

(Staphylococcus
aureus) 		PF00294
(PfkB) 		5 LEU A 169
LEU A 204
ILE A 219
VAL A 221
LEU A 197
 None
 1.01A 4y0pA-2jgvA:
undetectable		 4y0pA-2jgvA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okx RHAMNOSIDASE B

(Bacillus sp.
GL1) 		PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		5 VAL A 905
ILE A 935
VAL A 937
VAL A 939
LEU A 927
 None
 1.23A 4y0pA-2okxA:
undetectable		 4y0pA-2okxA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3x REGULATING SYNAPTIC
MEMBRANE EXOCYTOSIS
PROTEIN 1

(Rattus
norvegicus) 		PF00168
(C2) 		5 LEU A1531
VAL A1502
ILE A1465
VAL A1575
LEU A1569
 None
 1.03A 4y0pA-2q3xA:
undetectable		 4y0pA-2q3xA:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ro1 TRANSCRIPTION
INTERMEDIARY FACTOR
1-BETA

(Homo sapiens) 		PF00628
(PHD) 		5 LEU A 740
ILE A 743
VAL A 707
LEU A 788
PHE A 792
 None
 1.24A 4y0pA-2ro1A:
undetectable		 4y0pA-2ro1A:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhe SYNTAXIN1

(Monosiga
brevicollis) 		PF00804
(Syntaxin)
PF05739
(SNARE) 		5 LEU B 229
ILE B  64
VAL B 150
PHE B 147
MET B 151
 None
 1.14A 4y0pA-2xheB:
undetectable		 4y0pA-2xheB:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ygn WNT INHIBITORY
FACTOR 1

(Homo sapiens) 		PF02019
(WIF) 		5 LEU A  48
VAL A 136
VAL A 134
PHE A  89
MET A  87
 PCF  A1179 (-4.1A)
None
PCF  A1179 ( 4.7A)
PCF  A1179 ( 3.8A)
PCF  A1179 (-3.6A)
 1.06A 4y0pA-2ygnA:
undetectable		 4y0pA-2ygnA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ygo WNT INHIBITORY
FACTOR 1

(Homo sapiens) 		PF02019
(WIF) 		5 LEU A  48
VAL A 136
VAL A 134
PHE A  89
MET A  87
 PCF  A1213 (-4.3A)
None
PCF  A1213 ( 4.6A)
PCF  A1213 (-4.1A)
PCF  A1213 ( 3.8A)
 1.08A 4y0pA-2ygoA:
undetectable		 4y0pA-2ygoA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z0u WW DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00168
(C2) 		5 ILE A  25
ILE A  61
VAL A  63
VAL A  65
LEU A 130
 None
 1.10A 4y0pA-2z0uA:
undetectable		 4y0pA-2z0uA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z0u WW DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00168
(C2) 		5 ILE A  27
ILE A  61
VAL A  63
VAL A  65
LEU A 130
 None
 0.82A 4y0pA-2z0uA:
undetectable		 4y0pA-2z0uA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aii GLUTAMYL-TRNA
SYNTHETASE

(Methanothermobacter
thermautotrophicus) 		PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C) 		5 VAL A 143
LEU A 133
ILE A 135
ILE A 167
LEU A 109
 None
 0.90A 4y0pA-3aiiA:
undetectable		 4y0pA-3aiiA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9e CHITINASE A

(Vibrio harveyi) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		5 LEU A 142
VAL A 177
ILE A 188
ILE A 268
LEU A 580
 None
 1.28A 4y0pA-3b9eA:
undetectable		 4y0pA-3b9eA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bcq ALPHA-CHAIN
HEMOGLOBIN

(Brycon cephalus) 		PF00042
(Globin) 		5 LEU A  92
VAL A  94
VAL A  63
VAL A  67
LEU A 133
 HEM  A 143 (-4.1A)
HEM  A 143 (-4.5A)
HEM  A 143 (-4.3A)
None
HEM  A 143 (-4.9A)
 1.00A 4y0pA-3bcqA:
undetectable		 4y0pA-3bcqA:
28.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5h GLUCOCORTICOID
RECEPTOR DNA-BINDING
FACTOR 1

(Homo sapiens) 		PF00071
(Ras) 		5 LEU A 178
VAL A 181
LEU A  38
ILE A  33
VAL A 226
 None
None
None
GNP  A 301 (-4.3A)
None
 1.14A 4y0pA-3c5hA:
undetectable		 4y0pA-3c5hA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3q TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE

(Staphylococcus
epidermidis) 		PF01715
(IPPT) 		5 LEU A 300
LEU A 199
ILE A 201
LYS A 295
ILE A  12
 None
 1.11A 4y0pA-3d3qA:
undetectable		 4y0pA-3d3qA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ed3 PROTEIN
DISULFIDE-ISOMERASE
MPD1

(Saccharomyces
cerevisiae) 		PF00085
(Thioredoxin) 		5 VAL A 235
ILE A 163
ILE A 207
VAL A 179
PHE A 250
 None
 1.16A 4y0pA-3ed3A:
undetectable		 4y0pA-3ed3A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]

(Escherichia
coli) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 LEU A 272
LEU A 332
ILE A 226
ILE A 204
VAL A 248
 None
 1.17A 4y0pA-3eyaA:
undetectable		 4y0pA-3eyaA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f0h AMINOTRANSFERASE

([Eubacterium]
rectale) 		PF00266
(Aminotran_5) 		5 VAL A 208
LYS A 221
ILE A 198
VAL A 159
PHE A 157
 None
 1.20A 4y0pA-3f0hA:
undetectable		 4y0pA-3f0hA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f85 HOMO TRIMERIC FUSION
OF CFA/I FIMBRIAL
SUBUNITS B

(Escherichia
coli) 		PF04449
(Fimbrial_CS1) 		5 LEU A 155
VAL A 198
VAL A 196
LEU A 239
PHE A 234
 None
 0.87A 4y0pA-3f85A:
undetectable		 4y0pA-3f85A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f85 HOMO TRIMERIC FUSION
OF CFA/I FIMBRIAL
SUBUNITS B

(Escherichia
coli) 		PF04449
(Fimbrial_CS1) 		5 LEU A 306
VAL A 349
VAL A 347
LEU A 390
PHE A 385
 None
 0.82A 4y0pA-3f85A:
undetectable		 4y0pA-3f85A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gaf 7-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE

(Brucella
abortus) 		PF13561
(adh_short_C2) 		5 ILE A 187
ILE A 144
VAL A  93
VAL A  91
LEU A   9
 None
 1.18A 4y0pA-3gafA:
undetectable		 4y0pA-3gafA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h05 UNCHARACTERIZED
PROTEIN VPA0413

(Vibrio
parahaemolyticus) 		PF01467
(CTP_transf_like) 		5 ILE A 137
ILE A 142
VAL A  55
LEU A  33
PHE A  58
 None
 1.26A 4y0pA-3h05A:
undetectable		 4y0pA-3h05A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhe RIBOSE-5-PHOSPHATE
ISOMERASE A

(Bartonella
henselae) 		PF06026
(Rib_5-P_isom_A) 		5 LEU A  45
ILE A  47
ILE A  90
VAL A  88
LEU A  36
 None
 0.94A 4y0pA-3hheA:
undetectable		 4y0pA-3hheA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ix7 UNCHARACTERIZED
PROTEIN TTHA0540

(Thermus
thermophilus) 		no annotation 5 LEU A 150
LYS A 253
ILE A 257
VAL A 155
LEU A 209
 None
 1.10A 4y0pA-3ix7A:
undetectable		 4y0pA-3ix7A:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2u KINESIN-LIKE PROTEIN
KLP10A

(Drosophila
melanogaster) 		PF00225
(Kinesin) 		5 LEU K 352
ILE K 549
ILE K 279
VAL K 281
VAL K 283
 None
 1.24A 4y0pA-3j2uK:
undetectable		 4y0pA-3j2uK:
20.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kza BETA-LACTOGLOBULIN

(Bos taurus;
Equus caballus) 		PF00061
(Lipocalin) 		10 LEU A  39
VAL A  41
LEU A  54
ILE A  56
ILE A  71
ILE A  84
VAL A  92
VAL A  94
LEU A 103
PHE A 105
 None
 0.54A 4y0pA-3kzaA:
25.4		 4y0pA-3kzaA:
81.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kza BETA-LACTOGLOBULIN

(Bos taurus;
Equus caballus) 		PF00061
(Lipocalin) 		9 LEU A  39
VAL A  41
LEU A  54
ILE A  56
VAL A  92
VAL A  94
LEU A 103
PHE A 105
MET A 107
 None
 0.53A 4y0pA-3kzaA:
25.4		 4y0pA-3kzaA:
81.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kza BETA-LACTOGLOBULIN

(Bos taurus;
Equus caballus) 		PF00061
(Lipocalin) 		6 LEU A  39
VAL A  41
LEU A  54
LYS A  60
LEU A 103
PHE A 105
 None
 0.89A 4y0pA-3kzaA:
25.4		 4y0pA-3kzaA:
81.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ly9 TRANSCRIPTIONAL
ACTIVATOR CADC

(Escherichia
coli) 		no annotation 5 LEU A 381
ILE A 418
ILE A 407
VAL A 425
LEU A 455
 None
 1.02A 4y0pA-3ly9A:
undetectable		 4y0pA-3ly9A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzu PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT GAMMA
ISOFORM

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd) 		5 LEU A 987
ILE A 888
ILE A 952
LEU A 911
PHE A 928
 None
 1.21A 4y0pA-3nzuA:
undetectable		 4y0pA-3nzuA:
9.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ph5 BETA-LACTOGLOBULIN

(Bos taurus) 		PF00061
(Lipocalin) 		11 LEU A  55
VAL A  57
LEU A  70
ILE A  72
LYS A  76
ILE A  87
ILE A 100
VAL A 108
VAL A 110
LEU A 119
PHE A 121
 None
 0.61A 4y0pA-3ph5A:
29.0		 4y0pA-3ph5A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ph5 BETA-LACTOGLOBULIN

(Bos taurus) 		PF00061
(Lipocalin) 		9 LEU A  55
VAL A  57
LEU A  70
LYS A  76
VAL A 108
VAL A 110
LEU A 119
PHE A 121
MET A 123
 None
 0.61A 4y0pA-3ph5A:
29.0		 4y0pA-3ph5A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pie 5'->3'
EXORIBONUCLEASE
(XRN1)

(Kluyveromyces
lactis) 		PF03159
(XRN_N) 		5 LEU A 541
ILE A 330
ILE A 578
VAL A 570
LEU A 339
 None
 0.90A 4y0pA-3pieA:
undetectable		 4y0pA-3pieA:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3h HMW1C-LIKE
GLYCOSYLTRANSFERASE

(Actinobacillus
pleuropneumoniae) 		no annotation 5 VAL A  16
LEU A  98
ILE A  72
ILE A 113
LEU A  29
 None
 1.18A 4y0pA-3q3hA:
undetectable		 4y0pA-3q3hA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rr5 DNA LIGASE

(Thermococcus
sp. 1519) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		5 LEU A 347
ILE A 292
ILE A 289
VAL A 307
LEU A 300
 None
 1.11A 4y0pA-3rr5A:
undetectable		 4y0pA-3rr5A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqp ENOLASE

(Coxiella
burnetii) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 LEU A 191
ILE A 151
ILE A 169
ILE A 228
LEU A 214
 None
 1.09A 4y0pA-3tqpA:
undetectable		 4y0pA-3tqpA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1t DMMA HALOALKANE
DEHALOGENASE

(unidentified) 		PF00561
(Abhydrolase_1) 		5 LEU A  84
ILE A  88
ILE A 325
VAL A 220
LEU A 224
 None
 1.24A 4y0pA-3u1tA:
undetectable		 4y0pA-3u1tA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vn5 RIBONUCLEASE HIII

(Aquifex
aeolicus) 		PF01351
(RNase_HII) 		5 LEU A 218
VAL A 221
ILE A 251
ILE A  84
VAL A 237
 None
 1.16A 4y0pA-3vn5A:
undetectable		 4y0pA-3vn5A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxy PUTATIVE
UNCHARACTERIZED
PROTEIN CSYB

(Aspergillus
oryzae) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 LEU A 386
ILE A 352
ILE A 349
VAL A 279
LEU A 324
 None
 0.92A 4y0pA-3wxyA:
undetectable		 4y0pA-3wxyA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b9p TYPE 3A
CELLULOSE-BINDING
DOMAIN PROTEIN

(Ruminiclostridium
thermocellum) 		PF00942
(CBM_3) 		5 LEU A   9
VAL A 154
ILE A  90
ILE A 107
VAL A 105
 None
 1.05A 4y0pA-4b9pA:
undetectable		 4y0pA-4b9pA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bin N-ACETYLMURAMOYL-L-A
LANINE AMIDASE AMIC

(Escherichia
coli) 		PF01520
(Amidase_3)
PF11741
(AMIN) 		6 LEU A  84
VAL A  39
VAL A  73
LEU A 142
PHE A 115
MET A 113
 None
 1.26A 4y0pA-4binA:
undetectable		 4y0pA-4binA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bin N-ACETYLMURAMOYL-L-A
LANINE AMIDASE AMIC

(Escherichia
coli) 		PF01520
(Amidase_3)
PF11741
(AMIN) 		6 LEU A  84
VAL A  39
VAL A  73
VAL A  71
LEU A 142
MET A 113
 None
 1.10A 4y0pA-4binA:
undetectable		 4y0pA-4binA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cmr GLYCOSYL
HYDROLASE/DEACETYLAS
E FAMILY PROTEIN

(Pyrococcus sp.
ST04) 		no annotation 5 ILE A 271
ILE A 281
VAL A  75
VAL A  77
PHE A   9
 None
 1.08A 4y0pA-4cmrA:
undetectable		 4y0pA-4cmrA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewl 1D-MYO-INOSITOL
2-ACETAMIDO-2-DEOXY-
ALPHA-D-GLUCOPYRANOS
IDE DEACETYLASE

(Mycobacterium
tuberculosis) 		PF02585
(PIG-L) 		5 VAL A 227
LEU A  79
VAL A  35
VAL A  37
PHE A   9
 None
None
GOL  A 402 (-4.4A)
None
None
 0.97A 4y0pA-4ewlA:
undetectable		 4y0pA-4ewlA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fg0 POLYPROTEIN

(Saint Louis
encephalitis
virus) 		PF00869
(Flavi_glycoprot)
PF02832
(Flavi_glycop_C) 		5 VAL A 186
ILE A 297
VAL A  33
LEU A  25
PHE A  43
 None
 1.01A 4y0pA-4fg0A:
undetectable		 4y0pA-4fg0A:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwb HALOALKANE
DEHALOGENASE

(Rhodococcus
rhodochrous) 		PF00561
(Abhydrolase_1) 		5 LEU A  47
ILE A  51
ILE A 282
VAL A 177
LEU A 181
 None
 1.27A 4y0pA-4fwbA:
undetectable		 4y0pA-4fwbA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gbr BETA-2 ADRENERGIC
RECEPTOR

(Homo sapiens) 		PF00001
(7tm_1) 		5 LEU A 145
VAL A  67
ILE A 127
VAL A 222
LEU A 244
 None
 1.22A 4y0pA-4gbrA:
undetectable		 4y0pA-4gbrA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc6 RIBOSOME-RECYCLING
FACTOR

(Mycobacterium
tuberculosis) 		PF01765
(RRF) 		5 LEU A  87
LEU A  75
ILE A  98
ILE A  67
ILE A  51
 None
 1.10A 4y0pA-4kc6A:
undetectable		 4y0pA-4kc6A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lc9 GLUCOKINASE
REGULATORY PROTEIN

(Rattus
norvegicus) 		no annotation 5 LEU A 332
ILE A 409
ILE A 341
VAL A 489
LEU A 316
 None
 0.99A 4y0pA-4lc9A:
undetectable		 4y0pA-4lc9A:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lkb HYPOTHETICAL PROTEIN
ALR4568/PUTATIVE
4-OXALOCROTONATE
TAUTOMERASE

(Nostoc sp. PCC
7120) 		no annotation 5 VAL F  88
LEU F 103
ILE F 101
ILE F  64
ILE F   4
 None
 0.90A 4y0pA-4lkbF:
undetectable		 4y0pA-4lkbF:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lt6 POLY(A) POLYMERASE
GAMMA

(Homo sapiens) 		PF01909
(NTP_transf_2)
PF04926
(PAP_RNA-bind)
PF04928
(PAP_central) 		5 LEU A  61
LEU A 167
ILE A 165
ILE A 113
VAL A  71
 None
 1.16A 4y0pA-4lt6A:
undetectable		 4y0pA-4lt6A:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mxn UNCHARACTERIZED
PROTEIN

(Parabacteroides
merdae) 		PF00295
(Glyco_hydro_28) 		5 ILE A  71
ILE A 106
ILE A 122
VAL A  90
LEU A  39
 None
 1.21A 4y0pA-4mxnA:
undetectable		 4y0pA-4mxnA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4myo VIRGINIAMYCIN A
ACETYLTRANSFERASE

(Staphylococcus
aureus) 		PF00132
(Hexapep) 		5 ILE A 127
ILE A  74
ILE A  68
VAL A 155
LEU A 166
 None
 1.12A 4y0pA-4myoA:
undetectable		 4y0pA-4myoA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n9f TRANSCRIPTION
ELONGATION FACTOR B
POLYPEPTIDE 2

(Homo sapiens) 		no annotation 5 LEU X   5
ILE X   7
ILE X  14
VAL X  24
LEU X  51
 None
 1.15A 4y0pA-4n9fX:
undetectable		 4y0pA-4n9fX:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nk6 POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE

(Pseudomonas
syringae group
genomosp. 3) 		PF13229
(Beta_helix) 		5 VAL A 231
LEU A 145
ILE A 168
ILE A 178
MET A 201
 None
 1.23A 4y0pA-4nk6A:
undetectable		 4y0pA-4nk6A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5p UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF09994
(DUF2235) 		5 LEU A 803
VAL A 806
LEU A 716
VAL A 707
LEU A 603
 None
 0.98A 4y0pA-4o5pA:
undetectable		 4y0pA-4o5pA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8) 		5 LEU B 230
VAL B 233
LEU B 415
VAL B 312
VAL B 310
 None
 0.92A 4y0pA-4ov6B:
undetectable		 4y0pA-4ov6B:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozy POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE

(Pseudomonas
syringae group
genomosp. 3) 		PF13229
(Beta_helix) 		5 VAL A 231
LEU A 145
ILE A 168
ILE A 178
MET A 201
 None
 1.16A 4y0pA-4ozyA:
undetectable		 4y0pA-4ozyA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4px1 MALEYLACETOACETATE
ISOMERASE
(GLUTATHIONE
S-TRANSFERASE)

(Methylobacterium
extorquens) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 LEU A  82
VAL A 161
ILE A 169
VAL A 100
LEU A 142
 None
 1.24A 4y0pA-4px1A:
undetectable		 4y0pA-4px1A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qa8 PUTATIVE LIPOPROTEIN
LPRF

(Mycobacterium
bovis) 		PF07161
(LppX_LprAFG) 		5 LEU A  87
ILE A 200
ILE A 197
ILE A 236
VAL A  77
 None
 1.10A 4y0pA-4qa8A:
undetectable		 4y0pA-4qa8A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qbl VRR-NUC

(Psychrobacter
sp. PRwf-1) 		PF08774
(VRR_NUC) 		5 ILE A  88
ILE A 129
VAL A  17
VAL A  13
MET A  18
 None
 0.89A 4y0pA-4qblA:
undetectable		 4y0pA-4qblA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qdg PUTATIVE ADHESIN

(Bacteroides
thetaiotaomicron) 		PF08842
(Mfa2) 		5 LEU A 284
ILE A 202
VAL A 183
PHE A 311
MET A 309
 None
 0.93A 4y0pA-4qdgA:
undetectable		 4y0pA-4qdgA:
19.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r0b GLYCODELIN

(Homo sapiens) 		PF00061
(Lipocalin) 		6 LEU A  39
VAL A  41
LEU A  54
ILE A  56
ILE A  84
LEU A 103
 None
 0.62A 4y0pA-4r0bA:
21.4		 4y0pA-4r0bA:
41.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rca SLIT AND NTRK-LIKE
PROTEIN 1

(Homo sapiens) 		PF13855
(LRR_8) 		5 LEU B 252
VAL B 239
ILE B 207
VAL B 197
LEU B 169
 None
SO4  B 301 (-3.6A)
None
None
None
 1.20A 4y0pA-4rcaB:
undetectable		 4y0pA-4rcaB:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rca SLIT AND NTRK-LIKE
PROTEIN 1

(Homo sapiens) 		PF13855
(LRR_8) 		5 VAL B 239
ILE B 207
ILE B 230
VAL B 197
LEU B 169
 SO4  B 301 (-3.6A)
None
None
None
None
 1.10A 4y0pA-4rcaB:
undetectable		 4y0pA-4rcaB:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xiv CHEMOTAXIS PROTEIN
CHEA

(Thermotoga
maritima) 		PF02518
(HATPase_c)
PF02895
(H-kinase_dim) 		5 VAL A 533
ILE A 454
VAL A 488
PHE A 487
MET A 507
 None
ACP  A 601 ( 4.6A)
None
None
ACP  A 601 (-4.2A)
 0.96A 4y0pA-4xivA:
undetectable		 4y0pA-4xivA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y2l CFA/I FIMBRIAL
SUBUNIT B

(Escherichia
coli) 		PF04449
(Fimbrial_CS1) 		5 LEU A  17
VAL A  60
VAL A  58
LEU A 101
PHE A  96
 None
 0.85A 4y0pA-4y2lA:
undetectable		 4y0pA-4y2lA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z07 CGMP-DEPENDENT
PROTEIN KINASE 1

(Homo sapiens) 		PF00027
(cNMP_binding) 		5 LEU A 187
LEU A  96
ILE A 207
ILE A 130
MET A 216
 None
 1.20A 4y0pA-4z07A:
undetectable		 4y0pA-4z07A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cag UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF17145
(DUF5119) 		5 ILE A 264
ILE A 298
VAL A 166
LEU A 273
PHE A 164
 None
 0.74A 4y0pA-5cagA:
undetectable		 4y0pA-5cagA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chh ARAC FAMILY
TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		PF12625
(Arabinose_bd)
PF12833
(HTH_18) 		5 VAL A 146
ILE A 119
VAL A 117
VAL A 115
LEU A 196
 None
 1.20A 4y0pA-5chhA:
undetectable		 4y0pA-5chhA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5evm FUSION GLYCOPROTEIN
F0

(Nipah
henipavirus) 		PF00523
(Fusion_gly) 		5 LEU A 218
VAL A 213
ILE A 276
VAL A 278
VAL A 280
 None
 1.03A 4y0pA-5evmA:
undetectable		 4y0pA-5evmA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ftf TPR DOMAIN PROTEIN

(Bacteroides sp.
3_1_23) 		PF05970
(PIF1) 		5 ILE A 104
ILE A 107
VAL A 135
LEU A 122
PHE A 132
 None
 0.98A 4y0pA-5ftfA:
undetectable		 4y0pA-5ftfA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmb TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ

(Pseudomonas
aeruginosa) 		PF00588
(SpoU_methylase) 		5 VAL A 133
ILE A   5
VAL A   7
LEU A 146
PHE A 114
 None
 1.28A 4y0pA-5gmbA:
undetectable		 4y0pA-5gmbA:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzt CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		5 VAL B 397
ILE B 389
LYS B 396
ILE B 408
LEU B 339
 None
 1.22A 4y0pA-5gztB:
undetectable		 4y0pA-5gztB:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jn9 CARBONIC ANHYDRASE 4

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 LEU A 182
LEU A  95
ILE A 120
VAL A 148
LEU A 218
 None
 1.02A 4y0pA-5jn9A:
undetectable		 4y0pA-5jn9A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxm PRIB

(Streptomyces
sp. RM-5-8) 		PF11991
(Trp_DMAT) 		5 LEU A  46
VAL A  49
VAL A 379
VAL A 377
PHE A  99
 None
 1.14A 4y0pA-5jxmA:
2.1		 4y0pA-5jxmA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5knl UBIQUITIN-CONJUGATIN
G ENZYME E2 15

(Schizosaccharomyces
pombe) 		PF00179
(UQ_con) 		5 LEU C 121
ILE C  91
VAL C  89
PHE C  74
MET C  72
 None
 1.23A 4y0pA-5knlC:
undetectable		 4y0pA-5knlC:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2r FUMARATE HYDRATASE

(Leishmania
major) 		PF05681
(Fumerase)
PF05683
(Fumerase_C) 		5 LEU A 531
VAL A 541
LEU A 489
ILE A 447
VAL A 546
 None
 1.04A 4y0pA-5l2rA:
undetectable		 4y0pA-5l2rA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l8v DNA REPAIR AND
RECOMBINATION
PROTEIN RADA

(Pyrococcus
furiosus) 		PF08423
(Rad51) 		5 LEU A 268
LEU A 147
ILE A 236
VAL A 313
LEU A 124
 None
 0.93A 4y0pA-5l8vA:
undetectable		 4y0pA-5l8vA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lw0 BASIC
HELIX-LOOP-HELIX,
PUTATIVE, EXPRESSED

(Oryza sativa) 		PF01661
(Macro) 		5 LEU A 238
VAL A 250
ILE A 176
VAL A 256
LEU A 287
 None
None
AR6  A 301 (-4.0A)
None
None
 0.97A 4y0pA-5lw0A:
undetectable		 4y0pA-5lw0A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ny0 L. REUTERIS SRRP
BINDING REGION

(Lactobacillus
reuteri) 		no annotation 5 LEU A 296
ILE A 335
ILE A 305
VAL A 372
LEU A 383
 None
 1.26A 4y0pA-5ny0A:
undetectable		 4y0pA-5ny0A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5of4 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPD
SUBUNIT

(Homo sapiens) 		PF06733
(DEAD_2)
PF06777
(HBB)
PF13307
(Helicase_C_2) 		5 LEU B 597
ILE B 595
ILE B 535
ILE B 619
LEU B 558
 None
 0.93A 4y0pA-5of4B:
undetectable		 4y0pA-5of4B:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olj DIPEPTIDYL PEPTIDASE
IV

(Porphyromonas
gingivalis) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		5 LEU A 312
VAL A 307
LEU A 202
ILE A 281
VAL A 253
 None
 0.82A 4y0pA-5oljA:
undetectable		 4y0pA-5oljA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5osn CAPSID PROTEIN

(Enterovirus E) 		PF00073
(Rhv) 		5 ILE A  90
VAL A 175
VAL A 173
PHE A 114
MET A 112
 SPH  A 301 (-4.1A)
SPH  A 301 (-4.9A)
None
SPH  A 301 ( 4.2A)
SPH  A 301 ( 4.2A)
 1.02A 4y0pA-5osnA:
undetectable		 4y0pA-5osnA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo sapiens) 		no annotation 5 VAL A 192
LEU A 138
VAL A 112
LEU A 202
PHE A 113
 None
 1.14A 4y0pA-5tvtA:
undetectable		 4y0pA-5tvtA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujd SIDEROPHORE
BIOSYNTHESIS PROTEIN
SBNI

(Staphylococcus
pseudintermedius) 		no annotation 5 VAL A  47
LEU A 181
ILE A 186
ILE A 183
VAL A 200
 None
 1.25A 4y0pA-5ujdA:
undetectable		 4y0pA-5ujdA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7k LIPASE B

(Serratia
marcescens) 		no annotation 5 LEU A 391
LEU A 537
ILE A 355
VAL A 351
LEU A 348
 None
 1.22A 4y0pA-5x7kA:
undetectable		 4y0pA-5x7kA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xaq PROBABLE
D-TYROSYL-TRNA(TYR)
DEACYLASE 2

(Mus musculus) 		no annotation 5 LEU A  57
LEU A  42
ILE A  44
ILE A  89
VAL A  67
 None
 1.28A 4y0pA-5xaqA:
undetectable		 4y0pA-5xaqA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fju -

(-) 		no annotation 5 VAL A  13
LEU A  38
ILE A  40
ILE A   5
VAL A 133
 None
 0.82A 4y0pA-6fjuA:
undetectable		 4y0pA-6fjuA:
undetectable