SIMILAR PATTERNS OF AMINO ACIDS FOR 4Y03_B_SALB801

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ebl BETA-KETOACYL-ACP
SYNTHASE III

(Escherichia
coli) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 LEU A 189
ALA A 246
ASN A 247
ILE A 250
 COA  A1350 ( 4.8A)
COA  A1350 ( 3.7A)
COA  A1350 (-2.8A)
COA  A1350 (-3.2A)
 0.94A 4y03B-1eblA:
undetectable		 4y03B-1eblA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eov ASPARTYL-TRNA
SYNTHETASE

(Saccharomyces
cerevisiae) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 LEU A 140
ALA A 143
ASN A 144
ILE A 149
 None
 1.05A 4y03B-1eovA:
undetectable		 4y03B-1eovA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gt9 KUMAMOLYSIN

(Bacillus
subtilis) 		PF00082
(Peptidase_S8) 		4 LEU 1 195
TYR 1  15
ALA 1 254
ILE 1 317
 None
 1.19A 4y03B-1gt91:
undetectable		 4y03B-1gt91:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h0h FORMATE
DEHYDROGENASE
SUBUNIT ALPHA

(Desulfovibrio
gigas) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 LEU A 808
TYR A 329
ALA A 385
ILE A 242
 None
 1.11A 4y03B-1h0hA:
undetectable		 4y03B-1h0hA:
7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i4w MITOCHONDRIAL
REPLICATION PROTEIN
MTF1

(Saccharomyces
cerevisiae) 		PF00398
(RrnaAD) 		4 LEU A  75
TYR A  73
ALA A  62
ILE A   5
 None
 0.94A 4y03B-1i4wA:
0.0		 4y03B-1i4wA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ibq ASPERGILLOPEPSIN

(Aspergillus
phoenicis) 		PF00026
(Asp) 		4 LEU A 120
TYR A  74
ALA A  80
ILE A 107
 None
 1.15A 4y03B-1ibqA:
undetectable		 4y03B-1ibqA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5x SURVIVAL PROTEIN E

(Pyrobaculum
aerophilum) 		PF01975
(SurE) 		4 LEU A  19
TYR A 125
ALA A 153
ILE A  87
 None
 0.94A 4y03B-1l5xA:
0.0		 4y03B-1l5xA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lml LEISHMANOLYSIN

(Leishmania
major) 		PF01457
(Peptidase_M8) 		4 LEU A 389
TYR A 312
ALA A 340
ILE A 335
 None
 1.16A 4y03B-1lmlA:
undetectable		 4y03B-1lmlA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n21 (+)-BORNYL
DIPHOSPHATE SYNTHASE

(Salvia
officinalis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 LEU A  73
TYR A  69
ALA A 590
ILE A 589
 None
 1.18A 4y03B-1n21A:
3.4		 4y03B-1n21A:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ny5 TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)

(Aquifex
aeolicus) 		PF00072
(Response_reg)
PF00158
(Sigma54_activat) 		4 LEU A 380
ALA A 321
ASN A 322
ILE A 318
 None
 1.03A 4y03B-1ny5A:
undetectable		 4y03B-1ny5A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oyw ATP-DEPENDENT DNA
HELICASE

(Escherichia
coli) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF09382
(RQC)
PF16124
(RecQ_Zn_bind) 		4 LEU A 165
TYR A 162
ALA A 148
ILE A 192
 None
 1.09A 4y03B-1oywA:
0.0		 4y03B-1oywA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgu PROTEIN (NITROGENASE
MOLYBDENUM IRON
PROTEIN)

(Klebsiella
pneumoniae) 		PF00148
(Oxidored_nitro) 		4 LEU A 206
ALA A 281
ASN A 269
ILE A 224
 None
 1.03A 4y03B-1qguA:
undetectable		 4y03B-1qguA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1e KUMAMOLISIN

(Bacillus sp.
MN-32) 		PF00082
(Peptidase_S8)
PF09286
(Pro-kuma_activ) 		4 LEU A 384
TYR A 204
ALA A 443
ILE A 506
 None
 1.20A 4y03B-1t1eA:
undetectable		 4y03B-1t1eA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ug0 SPLICING FACTOR 4

(Mus musculus) 		PF01805
(Surp) 		4 LEU A  34
TYR A  73
ALA A  39
ILE A  80
 None
 1.09A 4y03B-1ug0A:
undetectable		 4y03B-1ug0A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urj MAJOR DNA-BINDING
PROTEIN

(Human
alphaherpesvirus
1) 		PF00747
(Viral_DNA_bp) 		4 LEU A 778
ALA A 897
ASN A 898
ILE A 881
 None
 1.18A 4y03B-1urjA:
undetectable		 4y03B-1urjA:
7.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 LEU A 167
TYR A 163
ALA A 112
ILE A 177
 None
 0.91A 4y03B-1w99A:
2.2		 4y03B-1w99A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wy1 HYPOTHETICAL PROTEIN
PH0671

(Pyrococcus
horikoshii) 		PF01923
(Cob_adeno_trans) 		4 LEU A 146
ALA A  30
ASN A  31
ILE A  70
 None
 0.90A 4y03B-1wy1A:
undetectable		 4y03B-1wy1A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xhl SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY MEMBER
(5L265), PUTATIVE
TROPINONE
REDUCTASE-II

(Caenorhabditis
elegans) 		PF13561
(adh_short_C2) 		4 LEU A 211
TYR A 212
ALA A 192
ILE A 222
 None
None
TNE  A1279 (-4.0A)
None
 1.15A 4y03B-1xhlA:
undetectable		 4y03B-1xhlA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3z DIALKYLGLYCINE
DECARBOXYLASE

(Burkholderia
cepacia) 		PF00202
(Aminotran_3) 		4 LEU A 106
TYR A 298
ALA A 118
ILE A 267
 None
 1.00A 4y03B-1z3zA:
undetectable		 4y03B-1z3zA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zx2 UBP3-ASSOCIATED
PROTEIN BRE5

(Saccharomyces
cerevisiae) 		PF02136
(NTF2) 		4 LEU A  81
TYR A  17
ALA A 102
ILE A  86
 None
 1.03A 4y03B-1zx2A:
undetectable		 4y03B-1zx2A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a3l AMP DEAMINASE

(Arabidopsis
thaliana) 		PF00962
(A_deaminase) 		4 LEU A 685
TYR A 695
ALA A 670
ILE A 339
 None
 0.86A 4y03B-2a3lA:
undetectable		 4y03B-2a3lA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cir HEXOSE-6-PHOSPHATE
MUTAROTASE

(Saccharomyces
cerevisiae) 		PF01263
(Aldose_epim) 		4 LEU A 126
TYR A 124
ALA A 112
ILE A 111
 None
 1.09A 4y03B-2cirA:
undetectable		 4y03B-2cirA:
16.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dat POSSIBLE GLOBAL
TRANSCRIPTION
ACTIVATOR SNF2L2

(Homo sapiens) 		PF00439
(Bromodomain) 		4 LEU A  43
ALA A  91
ASN A  95
ILE A 101
 None
 0.87A 4y03B-2datA:
16.9		 4y03B-2datA:
36.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f7v AECTYLCITRULLINE
DEACETYLASE

(Xanthomonas
campestris) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 LEU A 111
TYR A 354
ALA A 154
ILE A 104
 None
None
None
CO  A5367 ( 4.7A)
 1.03A 4y03B-2f7vA:
undetectable		 4y03B-2f7vA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g2p TRANSTHYRETIN-LIKE
PROTEIN

(Escherichia
coli) 		PF00576
(Transthyretin) 		4 LEU A  37
TYR A  62
ALA A  57
ILE A   5
 None
 1.05A 4y03B-2g2pA:
undetectable		 4y03B-2g2pA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II

(Caldanaerobacter
subterraneus) 		PF00753
(Lactamase_B) 		4 LEU A 179
ALA A 201
ASN A 158
ILE A 154
 None
 1.20A 4y03B-2p4zA:
undetectable		 4y03B-2p4zA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbz HYPOTHETICAL PROTEIN

(Thermococcus
kodakarensis) 		PF06849
(DUF1246)
PF06973
(DUF1297) 		4 LEU A 224
TYR A 279
ALA A 218
ILE A 217
 None
 1.06A 4y03B-2pbzA:
undetectable		 4y03B-2pbzA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfv EXOCYST COMPLEX
COMPONENT EXO70

(Saccharomyces
cerevisiae) 		PF03081
(Exo70) 		4 LEU A 402
TYR A 411
ASN A 441
ILE A 353
 None
 1.15A 4y03B-2pfvA:
undetectable		 4y03B-2pfvA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pv4 UNCHARACTERIZED
PROTEIN

(Shewanella
amazonensis) 		PF11269
(DUF3069) 		4 LEU A  26
TYR A  37
ALA A  78
ILE A  82
 None
 0.93A 4y03B-2pv4A:
undetectable		 4y03B-2pv4A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r0s CHROMATIN
STRUCTURE-REMODELING
COMPLEX PROTEIN RSC4

(Saccharomyces
cerevisiae) 		PF00439
(Bromodomain) 		4 TYR A 225
ALA A 264
ASN A 268
ILE A 274
 None
 0.36A 4y03B-2r0sA:
15.6		 4y03B-2r0sA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r0v CHROMATIN
STRUCTURE-REMODELING
COMPLEX PROTEIN RSC4

(Saccharomyces
cerevisiae) 		PF00439
(Bromodomain) 		4 TYR A 225
ALA A 264
ASN A 268
ILE A 274
 None
 0.40A 4y03B-2r0vA:
15.9		 4y03B-2r0vA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rds FE(II)/ALPHA-KETOGL
UTARATE DEPENDENT
HYDROXYLASE
1-DEOXYPENTALENIC
ACID 11-BETA
HYDROXYLASE

(Streptomyces
avermitilis) 		PF05721
(PhyH) 		4 LEU A 218
TYR A   8
ALA A 167
ILE A 229
 None
 1.06A 4y03B-2rdsA:
undetectable		 4y03B-2rdsA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Pseudomonas
aeruginosa) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 LEU A 191
ALA A 251
ASN A 252
ILE A 255
 None
 1.20A 4y03B-2x3eA:
undetectable		 4y03B-2x3eA:
14.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2yqd POLYBROMO-1

(Mus musculus) 		PF00439
(Bromodomain) 		4 LEU A  45
ALA A  93
ASN A  97
ILE A 103
 None
 0.87A 4y03B-2yqdA:
16.0		 4y03B-2yqdA:
96.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zab ALGINATE LYASE

(Sphingomonas
sp. A1) 		PF08787
(Alginate_lyase2) 		4 LEU A 237
ALA A 295
ASN A 283
ILE A 185
 None
 1.16A 4y03B-2zabA:
undetectable		 4y03B-2zabA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1f PUTATIVE PREPHENATE
DEHYDROGENASE

(Streptococcus
mutans) 		PF02153
(PDH) 		4 LEU A 166
TYR A 146
ALA A  97
ILE A  14
 None
None
NAD  A1001 (-4.7A)
NAD  A1001 (-4.0A)
 0.86A 4y03B-3b1fA:
undetectable		 4y03B-3b1fA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdk D-MANNONATE
DEHYDRATASE

(Streptococcus
suis) 		PF03786
(UxuA) 		4 LEU A 360
TYR A 356
ASN A 289
ILE A 309
 None
 1.13A 4y03B-3bdkA:
undetectable		 4y03B-3bdkA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwl ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 5

(Schizosaccharomyces
pombe) 		PF04699
(P16-Arc) 		4 LEU G  59
ALA G  52
ASN G  86
ILE G  47
 None
 1.16A 4y03B-3dwlG:
undetectable		 4y03B-3dwlG:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzb PREPHENATE
DEHYDROGENASE

(Streptococcus
thermophilus) 		PF02153
(PDH) 		4 LEU A 166
TYR A 146
ALA A  97
ILE A  14
 None
 1.02A 4y03B-3dzbA:
undetectable		 4y03B-3dzbA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e82 PUTATIVE
OXIDOREDUCTASE

(Klebsiella
pneumoniae) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 LEU A 338
ALA A 223
ASN A 220
ILE A 210
 None
 1.18A 4y03B-3e82A:
undetectable		 4y03B-3e82A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN 2

(Gallus gallus) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 LEU B 430
ALA B 425
ASN B 162
ILE B 244
 None
 1.14A 4y03B-3h1lB:
undetectable		 4y03B-3h1lB:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbd CLASS IV CHITINASE
CHIA4-PA2

(Picea abies) 		PF00182
(Glyco_hydro_19) 		4 LEU A 103
ALA A  84
ASN A  85
ILE A  81
 None
 1.14A 4y03B-3hbdA:
2.2		 4y03B-3hbdA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihs PHOSPHOCARRIER
PROTEIN HPR

(Bacillus
anthracis) 		PF00381
(PTS-HPr) 		4 LEU A  10
TYR A  80
ALA A  19
ILE A  50
 None
 1.01A 4y03B-3ihsA:
1.7		 4y03B-3ihsA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j47 26S PROTEASOME
REGULATORY SUBUNIT
RPN11
26S PROTEASOME
REGULATORY SUBUNIT
RPN3

(Saccharomyces
cerevisiae) 		PF08375
(Rpn3_C)
no annotation 		4 LEU V 288
ALA S 468
ASN S 469
ILE S 465
 None
 1.16A 4y03B-3j47V:
2.9		 4y03B-3j47V:
20.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k2j PROTEIN POLYBROMO-1

(Homo sapiens) 		PF00439
(Bromodomain) 		4 TYR A 388
ALA A 427
ASN A 431
ILE A 437
 None
 0.53A 4y03B-3k2jA:
19.3		 4y03B-3k2jA:
31.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kux PUTATIVE
OXIDOREDUCTASE

(Yersinia pestis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 LEU A 118
ALA A 104
ASN A 105
ILE A 324
 None
 1.07A 4y03B-3kuxA:
undetectable		 4y03B-3kuxA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lnb N-ACETYLTRANSFERASE
FAMILY PROTEIN

(Bacillus
anthracis) 		PF00797
(Acetyltransf_2) 		4 LEU A 260
ALA A 220
ASN A  40
ILE A 221
 None
None
None
COA  A1001 ( 3.8A)
 1.18A 4y03B-3lnbA:
undetectable		 4y03B-3lnbA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m0e TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)

(Aquifex
aeolicus) 		PF00158
(Sigma54_activat) 		4 LEU A 380
ALA A 321
ASN A 322
ILE A 318
 None
 1.07A 4y03B-3m0eA:
undetectable		 4y03B-3m0eA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m62 UBIQUITIN
CONJUGATION FACTOR
E4

(Saccharomyces
cerevisiae) 		PF04564
(U-box)
PF10408
(Ufd2P_core) 		4 LEU A 319
TYR A 392
ALA A 287
ILE A 349
 None
 0.87A 4y03B-3m62A:
undetectable		 4y03B-3m62A:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3noy 4-HYDROXY-3-METHYLBU
T-2-EN-1-YL
DIPHOSPHATE SYNTHASE

(Aquifex
aeolicus) 		PF04551
(GcpE) 		4 LEU A 157
ALA A 186
ASN A 187
ILE A 175
 None
 1.15A 4y03B-3noyA:
undetectable		 4y03B-3noyA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r2h BACTERIOFERRITIN

(Pseudomonas
aeruginosa) 		PF00210
(Ferritin) 		4 LEU A  14
TYR A  10
ALA A 101
ILE A 104
 None
 1.17A 4y03B-3r2hA:
3.2		 4y03B-3r2hA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rst SIGNAL PEPTIDE
PEPTIDASE SPPA

(Bacillus
subtilis) 		PF01343
(Peptidase_S49) 		4 LEU A 259
TYR A 251
ALA A 246
ILE A 231
 None
 1.02A 4y03B-3rstA:
undetectable		 4y03B-3rstA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s2u UDP-N-ACETYLGLUCOSAM
INE--N-ACETYLMURAMYL
-(PENTAPEPTIDE)
PYROPHOSPHORYL-UNDEC
APRENOL
N-ACETYLGLUCOSAMINE
TRANSFERASE

(Pseudomonas
aeruginosa) 		PF03033
(Glyco_transf_28)
PF04101
(Glyco_tran_28_C) 		4 LEU A  81
ALA A 111
ASN A 114
ILE A  88
 None
 1.09A 4y03B-3s2uA:
undetectable		 4y03B-3s2uA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t7l ZINC FINGER FYVE
DOMAIN-CONTAINING
PROTEIN 16

(Homo sapiens) 		PF01363
(FYVE) 		4 LEU A 790
TYR A 789
ALA A 771
ILE A 804
 LEU  A 790 ( 0.5A)
TYR  A 789 ( 1.3A)
ALA  A 771 ( 0.0A)
ILE  A 804 ( 0.7A)
 0.96A 4y03B-3t7lA:
undetectable		 4y03B-3t7lA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbj ACTIBIND

(Aspergillus
niger) 		PF00445
(Ribonuclease_T2) 		4 LEU A 169
TYR A 237
ALA A 232
ILE A 233
 None
 1.19A 4y03B-3tbjA:
undetectable		 4y03B-3tbjA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vbo GENOME POLYPROTEIN,
CAPSID PROTEIN VP2

(Enterovirus A) 		PF00073
(Rhv) 		4 LEU B 284
TYR B 199
ALA B 237
ILE B 239
 None
 1.20A 4y03B-3vboB:
undetectable		 4y03B-3vboB:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgq INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 5

(Homo sapiens) 		PF07719
(TPR_2)
PF13181
(TPR_8)
PF13374
(TPR_10)
PF13424
(TPR_12) 		4 LEU A 167
ALA A 207
ASN A 211
ILE A 178
 None
 1.06A 4y03B-3zgqA:
undetectable		 4y03B-3zgqA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zn8 SIGNAL RECOGNITION
PARTICLE 54 KDA
PROTEIN

(Sulfolobus
solfataricus) 		PF02978
(SRP_SPB) 		4 LEU M 389
TYR M 421
ALA M 380
ILE M 403
 None
 1.11A 4y03B-3zn8M:
undetectable		 4y03B-3zn8M:
27.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zv8 3C PROTEASE

(Enterovirus D) 		PF00548
(Peptidase_C3) 		4 LEU A  62
TYR A 178
ALA A 172
ILE A 160
 None
 1.18A 4y03B-3zv8A:
undetectable		 4y03B-3zv8A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d4g APNAA1

(Planktothrix
agardhii) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 LEU A  75
TYR A  81
ALA A 203
ILE A 206
 None
 1.00A 4y03B-4d4gA:
undetectable		 4y03B-4d4gA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e8d GLYCOSYL HYDROLASE,
FAMILY 35

(Streptococcus
pneumoniae) 		PF01301
(Glyco_hydro_35) 		4 LEU A 133
TYR A 129
ALA A  54
ILE A  95
 None
 1.17A 4y03B-4e8dA:
undetectable		 4y03B-4e8dA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmc RORF2

(Escherichia
coli) 		PF06872
(EspG) 		4 LEU A 384
TYR A 367
ALA A 286
ILE A 338
 None
 1.15A 4y03B-4fmcA:
undetectable		 4y03B-4fmcA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ghb HYPOTHETICAL PROTEIN

(Bacteroides
uniformis) 		PF15283
(DUF4595) 		4 LEU A 172
TYR A 162
ALA A 143
ILE A 249
 None
 1.17A 4y03B-4ghbA:
undetectable		 4y03B-4ghbA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ieg RNA-DEPENDENT RNA
POLYMERASE P2

(Pseudomonas
phage phi12) 		no annotation 4 LEU A 212
TYR A 208
ALA A 239
ILE A 306
 None
 1.18A 4y03B-4iegA:
undetectable		 4y03B-4iegA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4im4 ENDOGLUCANASE E

(Ruminiclostridium
thermocellum) 		PF00150
(Cellulase) 		4 LEU A 294
TYR A 335
ALA A 269
ILE A 267
 None
 1.17A 4y03B-4im4A:
undetectable		 4y03B-4im4A:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iv9 TRYPTOPHAN
2-MONOOXYGENASE

(Pseudomonas
savastanoi) 		PF01593
(Amino_oxidase) 		4 LEU A  13
TYR A 555
ALA A 193
ILE A 192
 None
 1.19A 4y03B-4iv9A:
undetectable		 4y03B-4iv9A:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jo0 CMLA

(Streptomyces
venezuelae) 		PF12706
(Lactamase_B_2) 		4 LEU A 473
TYR A 412
ALA A 401
ILE A 427
 None
 1.06A 4y03B-4jo0A:
undetectable		 4y03B-4jo0A:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kwb SIGNAL PEPTIDE
PEPTIDASE SPPA

(Bacillus
subtilis) 		PF01343
(Peptidase_S49) 		4 LEU A 259
TYR A 251
ALA A 246
ILE A 231
 None
 1.05A 4y03B-4kwbA:
undetectable		 4y03B-4kwbA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l4u TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)

(Aquifex
aeolicus) 		PF00072
(Response_reg)
PF00158
(Sigma54_activat) 		4 LEU A 380
ALA A 321
ASN A 322
ILE A 318
 None
 0.99A 4y03B-4l4uA:
undetectable		 4y03B-4l4uA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mad BETA-GALACTOSIDASE

(Bacillus
circulans) 		PF01301
(Glyco_hydro_35) 		4 LEU A 134
TYR A 130
ALA A  54
ILE A  95
 None
 1.14A 4y03B-4madA:
undetectable		 4y03B-4madA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mmo SSO-CP2
METALLO-CARBOXYPETID
ASE

(Sulfolobus
solfataricus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 LEU A 167
TYR A 367
ALA A 423
ILE A 399
 None
 0.82A 4y03B-4mmoA:
undetectable		 4y03B-4mmoA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfb C4-DICARBOXYLATE-BIN
DING PROTEIN

(Fusobacterium
nucleatum) 		PF03480
(DctP) 		4 LEU A 141
TYR A 100
ALA A 131
ILE A 136
 None
 1.02A 4y03B-4pfbA:
undetectable		 4y03B-4pfbA:
15.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4q0n PROTEIN POLYBROMO-1

(Homo sapiens) 		PF00439
(Bromodomain) 		5 LEU A 655
TYR A 664
ALA A 703
ASN A 707
ILE A 713
 2XD  A 802 ( 4.3A)
2XD  A 802 (-4.4A)
2XD  A 802 (-3.4A)
2XD  A 802 (-3.4A)
2XD  A 802 (-4.6A)
 0.37A 4y03B-4q0nA:
22.3		 4y03B-4q0nA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q48 DNA HELICASE RECQ

(Deinococcus
radiodurans) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF09382
(RQC)
PF16124
(RecQ_Zn_bind) 		4 LEU A 164
TYR A 161
ALA A 147
ILE A 191
 None
 1.15A 4y03B-4q48A:
undetectable		 4y03B-4q48A:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yw5 NEURAMINIDASE C

(Streptococcus
pneumoniae) 		PF02012
(BNR)
PF02973
(Sialidase)
PF13088
(BNR_2) 		4 LEU A 150
TYR A 120
ALA A 205
ASN A 206
 None
None
GOL  A 804 (-3.9A)
GOL  A 804 (-3.7A)
 1.09A 4y03B-4yw5A:
undetectable		 4y03B-4yw5A:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE

(Geobacillus
stearothermophilus) 		PF00232
(Glyco_hydro_1) 		4 TYR A 258
ALA A 201
ASN A 198
ILE A 175
 None
 1.20A 4y03B-4zfmA:
undetectable		 4y03B-4zfmA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zqg 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Moraxella
catarrhalis) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		4 LEU A 350
ALA A 345
ASN A 342
ILE A 359
 None
 1.20A 4y03B-4zqgA:
undetectable		 4y03B-4zqgA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2a APO FORM OF
ANOXYBACILLUS
ALPHA-AMYLASES

(Anoxybacillus
ayderensis) 		PF00128
(Alpha-amylase) 		4 LEU A 380
TYR A 376
ALA A 466
ILE A 420
 None
 1.17A 4y03B-5a2aA:
undetectable		 4y03B-5a2aA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5abj VP2

(Enterovirus A) 		PF00073
(Rhv) 		4 LEU B 215
TYR B 130
ALA B 168
ILE B 170
 None
 1.16A 4y03B-5abjB:
undetectable		 4y03B-5abjB:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c8c VP0

(Enterovirus A) 		PF00073
(Rhv)
PF02226
(Pico_P1A) 		4 LEU B 284
TYR B 199
ALA B 237
ILE B 239
 None
 1.11A 4y03B-5c8cB:
undetectable		 4y03B-5c8cB:
13.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dkc PROBABLE GLOBAL
TRANSCRIPTION
ACTIVATOR SNF2L2

(Homo sapiens) 		PF00439
(Bromodomain) 		5 LEU A1412
TYR A1421
ALA A1460
ASN A1464
ILE A1470
 5BW  A1502 (-4.2A)
5BW  A1502 (-4.5A)
5BW  A1502 (-3.5A)
5BW  A1502 (-3.2A)
5BW  A1502 (-4.9A)
 0.41A 4y03B-5dkcA:
20.6		 4y03B-5dkcA:
36.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dkd TRANSCRIPTION
ACTIVATOR BRG1

(Homo sapiens) 		PF00439
(Bromodomain) 		5 LEU A1488
TYR A1497
ALA A1536
ASN A1540
ILE A1546
 5BW  A1605 (-4.0A)
5BW  A1605 (-4.6A)
5BW  A1605 (-3.4A)
5BW  A1605 (-3.3A)
None
 0.46A 4y03B-5dkdA:
19.6		 4y03B-5dkdA:
39.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dv5 GNTR FAMILY
TRANSCRIPTIONAL
REGULATOR

(Vibrio
alginolyticus) 		PF00392
(GntR)
PF07840
(FadR_C) 		4 LEU A  86
ALA A  94
ASN A  93
ILE A  17
 None
 1.09A 4y03B-5dv5A:
undetectable		 4y03B-5dv5A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ewq AMIDASE

(Bacillus
anthracis) 		PF01425
(Amidase) 		4 LEU A 362
TYR A 524
ALA A 494
ASN A 530
 None
 1.09A 4y03B-5ewqA:
undetectable		 4y03B-5ewqA:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h0i ASPARAGINYL
ENDOPEPTIDASE

(Oldenlandia
affinis) 		PF01650
(Peptidase_C13) 		4 LEU A 214
ALA A 191
ASN A 195
ILE A 226
 None
 1.13A 4y03B-5h0iA:
undetectable		 4y03B-5h0iA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hnm D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Enterococcus
faecalis) 		PF02557
(VanY) 		4 LEU A  91
TYR A 263
ALA A 250
ILE A 222
 None
 0.94A 4y03B-5hnmA:
undetectable		 4y03B-5hnmA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kha GLUTAMINE-DEPENDENT
NAD+ SYNTHETASE

(Acinetobacter
baumannii) 		PF00795
(CN_hydrolase)
PF02540
(NAD_synthase) 		4 LEU A  57
TYR A 125
ALA A  52
ILE A  48
 None
EDO  A 601 ( 4.7A)
EDO  A 601 (-3.4A)
None
 1.05A 4y03B-5khaA:
undetectable		 4y03B-5khaA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o9h C5A ANAPHYLATOXIN
CHEMOTACTIC RECEPTOR
1

(Homo sapiens) 		no annotation 4 LEU A 323
TYR A 300
ALA A  79
ASN A  55
 None
 1.16A 4y03B-5o9hA:
undetectable		 4y03B-5o9hA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tr7 D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Vibrio cholerae) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		4 LEU A 191
TYR A 202
ASN A 122
ILE A  76
 None
 1.12A 4y03B-5tr7A:
undetectable		 4y03B-5tr7A:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u89 AMINO ACID
ADENYLATION DOMAIN
PROTEIN

(Geobacillus sp.
Y4.1MC1) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF13193
(AMP-binding_C) 		4 LEU A 528
TYR A 534
ALA A 659
ILE A 662
 None
 0.98A 4y03B-5u89A:
undetectable		 4y03B-5u89A:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uaz NUCLEOPORIN NUP53

(Saccharomyces
cerevisiae) 		no annotation 4 LEU A 316
TYR A 318
ALA A 271
ILE A 283
 None
 1.10A 4y03B-5uazA:
undetectable		 4y03B-5uazA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6v RAGULATOR COMPLEX
PROTEIN LAMTOR2

(Homo sapiens) 		no annotation 4 LEU B  23
TYR B  94
ALA B  49
ILE B  83
 None
 1.10A 4y03B-5x6vB:
undetectable		 4y03B-5x6vB:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8r 30S RIBOSOMAL
PROTEIN S9,
CHLOROPLASTIC

(Spinacia
oleracea) 		no annotation 4 LEU i 139
TYR i 104
ALA i 134
ILE i 146
 C  a1197 ( 4.5A)
A  a1196 ( 4.7A)
None
None
 1.13A 4y03B-5x8ri:
undetectable		 4y03B-5x8ri:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbn WSS1P

(Saccharomyces
cerevisiae) 		no annotation 4 LEU A 117
ALA A  52
ASN A  26
ILE A  29
 None
 1.18A 4y03B-5xbnA:
2.6		 4y03B-5xbnA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xge UNCHARACTERIZED
PROTEIN PA0861

(Pseudomonas
aeruginosa) 		no annotation 4 LEU A 707
ALA A 691
ASN A 687
ILE A 652
 None
 1.12A 4y03B-5xgeA:
undetectable		 4y03B-5xgeA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yhh UNCHARACTERIZED
CONSERVED PROTEIN
YIIM

(Geobacillus
stearothermophilus) 		no annotation 4 LEU A 128
TYR A  74
ALA A 134
ILE A 135
 None
 1.20A 4y03B-5yhhA:
undetectable		 4y03B-5yhhA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z67 DNA REPLICATION AND
REPAIR PROTEIN RECF

(Caldanaerobacter
subterraneus) 		no annotation 4 LEU A 238
ALA A 228
ASN A 226
ILE A 194
 None
 0.83A 4y03B-5z67A:
undetectable		 4y03B-5z67A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c1q SOLUBLE CYTOCHROME
B562, C5A
ANAPHYLATOXIN
CHEMOTACTIC RECEPTOR
1 CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 4 LEU B 409
TYR B 386
ALA B 165
ASN B 141
 None
 1.13A 4y03B-6c1qB:
2.3		 4y03B-6c1qB:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9k DARP14 - SUBUNIT A
WITH DARPIN

(synthetic
construct) 		no annotation 4 LEU A 146
ALA A  30
ASN A  31
ILE A  70
 None
 1.06A 4y03B-6c9kA:
undetectable		 4y03B-6c9kA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH DEHYDROGENASE
[UBIQUINONE]
FLAVOPROTEIN 1,
MITOCHONDRIAL

(Mus musculus) 		no annotation 4 LEU F 123
TYR F 171
ALA F 128
ILE F  56
 None
 1.13A 4y03B-6g2jF:
undetectable		 4y03B-6g2jF:
18.90