SIMILAR PATTERNS OF AMINO ACIDS FOR 4Y03_A_SALA801

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cb8 PROTEIN
(CHONDROITINASE AC)

(Pedobacter
heparinus) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		4 ILE A  89
LEU A  82
ALA A 112
ILE A 109
 None
 0.86A 4y03A-1cb8A:
undetectable		 4y03A-1cb8A:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e96 NEUTROPHIL CYTOSOL
FACTOR 2 (NCF-2) TPR
DOMAIN, RESIDUES
1-203

(Homo sapiens) 		PF07719
(TPR_2)
PF13181
(TPR_8) 		4 ILE B 127
MET B  79
ALA B  90
ILE B  91
 None
 0.81A 4y03A-1e96B:
undetectable		 4y03A-1e96B:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jji CARBOXYLESTERASE

(Archaeoglobus
fulgidus) 		PF07859
(Abhydrolase_3) 		4 ILE A 187
LEU A 248
ALA A 300
ILE A 288
 None
 0.87A 4y03A-1jjiA:
undetectable		 4y03A-1jjiA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5x SURVIVAL PROTEIN E

(Pyrobaculum
aerophilum) 		PF01975
(SurE) 		5 ILE A   3
LEU A  19
TYR A 125
ALA A 153
ILE A  87
 None
 1.35A 4y03A-1l5xA:
undetectable		 4y03A-1l5xA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mns MANDELATE RACEMASE

(Pseudomonas
putida) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A  73
LEU A  78
ALA A 110
ILE A 107
 None
 0.81A 4y03A-1mnsA:
undetectable		 4y03A-1mnsA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nrz PTS SYSTEM,
SORBOSE-SPECIFIC IIB
COMPONENT

(Klebsiella
pneumoniae) 		PF03830
(PTSIIB_sorb) 		4 ILE A 128
ALA A 162
ASN A 159
ILE A 158
 None
 0.77A 4y03A-1nrzA:
undetectable		 4y03A-1nrzA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofu CELL DIVISION
PROTEIN FTSZ

(Pseudomonas
aeruginosa) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		4 ILE A  89
LEU A  83
ALA A 113
ILE A 117
 None
 0.80A 4y03A-1ofuA:
undetectable		 4y03A-1ofuA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p31 UDP-N-ACETYLMURAMATE
--ALANINE LIGASE

(Haemophilus
influenzae) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 ILE A  26
LEU A  39
ALA A  60
ILE A  66
 None
 0.81A 4y03A-1p31A:
undetectable		 4y03A-1p31A:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pem RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 2
ALPHA CHAIN

(Salmonella
enterica) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF08343
(RNR_N) 		4 ILE A 694
LEU A 691
ALA A 679
ILE A 676
 None
 0.79A 4y03A-1pemA:
undetectable		 4y03A-1pemA:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sc6 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Escherichia
coli) 		PF00389
(2-Hacid_dh)
PF01842
(ACT)
PF02826
(2-Hacid_dh_C) 		4 ILE A 381
LEU A 332
ALA A 366
ILE A 365
 None
 0.84A 4y03A-1sc6A:
undetectable		 4y03A-1sc6A:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1smr RENIN

(Mus musculus) 		PF00026
(Asp) 		4 ILE A 258
LEU A 255
ALA A 234
ILE A 231
 None
 0.84A 4y03A-1smrA:
undetectable		 4y03A-1smrA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbk HYPOTHETICAL PROTEIN
PH1313

(Pyrococcus
horikoshii) 		PF02568
(ThiI)
PF02926
(THUMP) 		5 ILE A 154
MET A  94
ALA A  91
ASN A  88
ILE A  87
 None
 1.48A 4y03A-1vbkA:
undetectable		 4y03A-1vbkA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vff BETA-GLUCOSIDASE

(Pyrococcus
horikoshii) 		PF00232
(Glyco_hydro_1) 		4 ILE A 322
LEU A 320
ALA A 309
ILE A 306
 None
 0.74A 4y03A-1vffA:
undetectable		 4y03A-1vffA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w5f CELL DIVISION
PROTEIN FTSZ

(Thermotoga
maritima) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		4 ILE A  99
LEU A  93
ALA A 123
ILE A 127
 None
 0.76A 4y03A-1w5fA:
undetectable		 4y03A-1w5fA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8g HYPOTHETICAL UPF0001
PROTEIN YGGS

(Escherichia
coli) 		PF01168
(Ala_racemase_N) 		4 ILE A  29
LEU A 200
ALA A 211
ILE A 212
 None
 0.82A 4y03A-1w8gA:
undetectable		 4y03A-1w8gA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE

(Alcaligenaceae
bacterium FB188) 		PF00850
(Hist_deacetyl) 		4 ILE A 304
LEU A 177
ALA A 289
ILE A 293
 None
 0.79A 4y03A-1zz3A:
undetectable		 4y03A-1zz3A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a3l AMP DEAMINASE

(Arabidopsis
thaliana) 		PF00962
(A_deaminase) 		4 LEU A 685
TYR A 695
ALA A 670
ILE A 339
 None
 0.80A 4y03A-2a3lA:
undetectable		 4y03A-2a3lA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfa THYMIDYLATE SYNTHASE

(Paramecium
bursaria
Chlorella virus
1) 		PF02511
(Thy1) 		4 ILE B 209
MET B  62
ALA B  60
ILE B  23
 None
 0.78A 4y03A-2cfaB:
undetectable		 4y03A-2cfaB:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cq0 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT 4

(Homo sapiens) 		PF00076
(RRM_1) 		4 ILE A 285
LEU A 258
ALA A 296
ILE A 241
 None
 0.79A 4y03A-2cq0A:
undetectable		 4y03A-2cq0A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0i DEHYDROGENASE

(Pyrococcus
horikoshii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 ILE A 157
LEU A  97
ALA A 286
ILE A 234
 None
 0.86A 4y03A-2d0iA:
undetectable		 4y03A-2d0iA:
19.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dat POSSIBLE GLOBAL
TRANSCRIPTION
ACTIVATOR SNF2L2

(Homo sapiens) 		PF00439
(Bromodomain) 		4 LEU A  43
ALA A  91
ASN A  95
ILE A 101
 None
 0.76A 4y03A-2datA:
16.9		 4y03A-2datA:
36.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dat POSSIBLE GLOBAL
TRANSCRIPTION
ACTIVATOR SNF2L2

(Homo sapiens) 		PF00439
(Bromodomain) 		4 LEU A  43
TYR A  52
ALA A  91
ILE A 101
 None
 0.85A 4y03A-2datA:
16.9		 4y03A-2datA:
36.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dlz PROTEIN VAV-2

(Homo sapiens) 		PF00017
(SH2) 		4 ILE A  76
LEU A  85
ALA A  53
ILE A  65
 None
 0.84A 4y03A-2dlzA:
undetectable		 4y03A-2dlzA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dvr BROMODOMAIN-CONTAINI
NG PROTEIN 2

(Homo sapiens) 		PF00439
(Bromodomain) 		4 TYR A  47
MET A  82
ASN A  90
ILE A  96
 None
 0.58A 4y03A-2dvrA:
15.2		 4y03A-2dvrA:
27.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e54 ACETYLORNITHINE
AMINOTRANSFERASE

(Thermotoga
maritima) 		PF00202
(Aminotran_3) 		4 ILE A 119
LEU A 207
ALA A 101
ILE A 102
 None
 0.83A 4y03A-2e54A:
undetectable		 4y03A-2e54A:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gai DNA TOPOISOMERASE I

(Thermotoga
maritima) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		4 ILE A  20
LEU A  80
ALA A 122
ILE A 119
 None
 0.87A 4y03A-2gaiA:
undetectable		 4y03A-2gaiA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gca FOLYLPOLYGLUTAMATE
SYNTHASE

(Lactobacillus
casei) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 ILE A 288
LEU A  61
ALA A 268
ILE A 269
 None
 0.74A 4y03A-2gcaA:
undetectable		 4y03A-2gcaA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 ILE A 349
LEU A 342
ALA A 431
ILE A 310
 None
OHT  A 500 ( 4.7A)
OHT  A 500 (-4.3A)
None
 0.77A 4y03A-2gpvA:
undetectable		 4y03A-2gpvA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jzy TRANSCRIPTIONAL
REGULATORY PROTEIN
PCOR

(Klebsiella
pneumoniae) 		PF00486
(Trans_reg_C) 		4 ILE A  53
LEU A  37
ALA A  72
ILE A  69
 None
 0.64A 4y03A-2jzyA:
undetectable		 4y03A-2jzyA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o69 IRON-UTILIZATION
PERIPLASMIC PROTEIN

(Haemophilus
influenzae) 		PF01547
(SBP_bac_1) 		4 ILE A  74
LEU A  71
ALA A 230
ILE A  96
 None
 0.83A 4y03A-2o69A:
undetectable		 4y03A-2o69A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ocp DEOXYGUANOSINE
KINASE

(Homo sapiens) 		PF01712
(dNK) 		4 ILE A 214
LEU A 216
ASN A  46
ILE A  47
 None
None
None
DTP  A 301 (-3.8A)
 0.78A 4y03A-2ocpA:
undetectable		 4y03A-2ocpA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pnw MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE

(Agrobacterium
fabrum) 		PF03562
(MltA)
PF06725
(3D) 		4 ILE A 202
LEU A 104
ALA A 173
ILE A 172
 None
 0.72A 4y03A-2pnwA:
undetectable		 4y03A-2pnwA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pv4 UNCHARACTERIZED
PROTEIN

(Shewanella
amazonensis) 		PF11269
(DUF3069) 		4 LEU A  26
TYR A  37
ALA A  78
ILE A  82
 None
 0.67A 4y03A-2pv4A:
undetectable		 4y03A-2pv4A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qv2 INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1

(Homo sapiens) 		PF00620
(RhoGAP) 		4 ILE A 221
LEU A 186
ALA A 231
ILE A 209
 ILE  A 221 ( 0.7A)
LEU  A 186 ( 0.6A)
ALA  A 231 ( 0.0A)
ILE  A 209 ( 0.7A)
 0.86A 4y03A-2qv2A:
undetectable		 4y03A-2qv2A:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyb MEMBRANE PROTEIN,
PUTATIVE

(Geobacter
sulfurreducens) 		PF13185
(GAF_2) 		4 ILE A  38
LEU A  23
ALA A 147
ILE A 113
 None
 0.85A 4y03A-2qybA:
undetectable		 4y03A-2qybA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r0s CHROMATIN
STRUCTURE-REMODELING
COMPLEX PROTEIN RSC4

(Saccharomyces
cerevisiae) 		PF00439
(Bromodomain) 		4 TYR A 225
ALA A 264
ASN A 268
ILE A 274
 None
 0.50A 4y03A-2r0sA:
15.5		 4y03A-2r0sA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r0v CHROMATIN
STRUCTURE-REMODELING
COMPLEX PROTEIN RSC4

(Saccharomyces
cerevisiae) 		PF00439
(Bromodomain) 		4 TYR A 225
ALA A 264
ASN A 268
ILE A 274
 None
 0.55A 4y03A-2r0vA:
15.9		 4y03A-2r0vA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6r CELL DIVISION
PROTEIN FTSZ

(Aquifex
aeolicus) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		4 ILE 1  85
LEU 1  79
ALA 1 109
ILE 1 113
 None
 0.76A 4y03A-2r6r1:
undetectable		 4y03A-2r6r1:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vaw CELL DIVISION
PROTEIN FTSZ

(Pseudomonas
aeruginosa) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		4 ILE A  89
LEU A  83
ALA A 113
ILE A 117
 None
 0.74A 4y03A-2vawA:
undetectable		 4y03A-2vawA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y4f PEROXIDASE YCDB

(Escherichia
coli) 		PF04261
(Dyp_perox) 		4 ILE A 295
LEU A 297
ALA A 290
ILE A 289
 HEM  A 389 (-4.5A)
None
None
None
 0.83A 4y03A-2y4fA:
undetectable		 4y03A-2y4fA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yek BROMODOMAIN-CONTAINI
NG PROTEIN 2

(Homo sapiens) 		PF00439
(Bromodomain) 		4 TYR A 113
MET A 148
ASN A 156
ILE A 162
 None
None
EAM  A1188 (-3.2A)
EAM  A1188 (-3.8A)
 0.64A 4y03A-2yekA:
15.0		 4y03A-2yekA:
29.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2yqd POLYBROMO-1

(Mus musculus) 		PF00439
(Bromodomain) 		6 ILE A  41
LEU A  45
MET A  89
ALA A  93
ASN A  97
ILE A 103
 None
 0.98A 4y03A-2yqdA:
15.8		 4y03A-2yqdA:
96.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ze4 PHOSPHOLIPASE D

(Streptomyces
antibioticus) 		PF13091
(PLDc_2) 		4 ILE A  12
LEU A 321
TYR A 454
ILE A 267
 None
 0.80A 4y03A-2ze4A:
undetectable		 4y03A-2ze4A:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ci0 PSEUDOPILIN GSPK

(Escherichia
coli) 		PF03934
(T2SSK) 		4 ILE K 206
LEU K 267
ALA K 221
ILE K 218
 None
 0.84A 4y03A-3ci0K:
undetectable		 4y03A-3ci0K:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		4 ILE A 377
MET A 408
ALA A 406
ILE A 404
 None
 0.79A 4y03A-3ecqA:
undetectable		 4y03A-3ecqA:
6.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN

(Plexaura
homomalla) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 TYR A 678
ALA A 695
ASN A 717
ILE A 716
 None
 0.68A 4y03A-3fg4A:
undetectable		 4y03A-3fg4A:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3go4 PROTEIN OF UNKNOWN
FUNCTION DUF574

(Streptomyces
avermitilis) 		PF04672
(Methyltransf_19) 		4 ILE A  84
TYR A 134
ALA A 137
ILE A 145
 None
 0.83A 4y03A-3go4A:
undetectable		 4y03A-3go4A:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihs PHOSPHOCARRIER
PROTEIN HPR

(Bacillus
anthracis) 		PF00381
(PTS-HPr) 		4 ILE A  55
LEU A  10
TYR A  80
ALA A  19
 None
 0.87A 4y03A-3ihsA:
undetectable		 4y03A-3ihsA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ij3 CYTOSOL
AMINOPEPTIDASE

(Coxiella
burnetii) 		PF00883
(Peptidase_M17) 		4 ILE A 182
LEU A 188
ALA A 278
ILE A 209
 None
 0.83A 4y03A-3ij3A:
undetectable		 4y03A-3ij3A:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j81 EIF2 ALPHA

(Saccharomyces
cerevisiae) 		PF00163
(Ribosomal_S4)
PF01479
(S4) 		4 ILE j  59
LEU j  51
ALA j  32
ILE j  27
 None
 0.84A 4y03A-3j81j:
2.3		 4y03A-3j81j:
19.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k2j PROTEIN POLYBROMO-1

(Homo sapiens) 		PF00439
(Bromodomain) 		5 TYR A 388
MET A 423
ALA A 427
ASN A 431
ILE A 437
 None
 0.62A 4y03A-3k2jA:
19.2		 4y03A-3k2jA:
31.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kf8 PROTEIN TEN1

(Candida
tropicalis) 		PF12658
(Ten1) 		4 ILE B  60
LEU B  65
ALA B  84
ILE B  91
 None
 0.86A 4y03A-3kf8B:
undetectable		 4y03A-3kf8B:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpo PREDICTED HYDROLASE
OF THE HAD
SUPERFAMILY

(Lactobacillus
brevis) 		PF08282
(Hydrolase_3) 		4 ILE A   6
LEU A 232
ALA A 262
ILE A 263
 None
 0.83A 4y03A-3mpoA:
undetectable		 4y03A-3mpoA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o57 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		4 ILE A 199
LEU A 192
ALA A 271
ILE A 268
 None
 0.76A 4y03A-3o57A:
undetectable		 4y03A-3o57A:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o6n APL1

(Anopheles
gambiae) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 LEU A 315
ALA A 345
ASN A 348
ILE A 350
 None
 0.84A 4y03A-3o6nA:
undetectable		 4y03A-3o6nA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o80 HEXOKINASE

(Kluyveromyces
lactis) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		4 ILE A 202
LEU A  85
ALA A 131
ILE A 200
 None
 0.85A 4y03A-3o80A:
undetectable		 4y03A-3o80A:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oja ANOPHELES
PLASMODIUM-RESPONSIV
E LEUCINE-RICH
REPEAT PROTEIN 1

(Anopheles
gambiae) 		PF13855
(LRR_8) 		4 LEU B 315
ALA B 345
ASN B 348
ILE B 350
 None
 0.86A 4y03A-3ojaB:
undetectable		 4y03A-3ojaB:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pa8 TOXIN B

(Clostridioides
difficile) 		PF11713
(Peptidase_C80) 		4 ILE A  35
LEU A 105
ALA A 139
ILE A  93
 None
 0.66A 4y03A-3pa8A:
undetectable		 4y03A-3pa8A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppx VON WILLEBRAND
FACTOR

(Homo sapiens) 		PF00092
(VWA) 		4 ILE A1642
TYR A1542
ALA A1612
ILE A1616
 None
 0.79A 4y03A-3ppxA:
undetectable		 4y03A-3ppxA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qw4 UMP SYNTHASE

(Leishmania
donovani) 		PF00156
(Pribosyltran)
PF00215
(OMPdecase) 		5 ILE B 370
LEU B 400
MET B 300
ALA B 304
ILE B 333
 None
 1.14A 4y03A-3qw4B:
undetectable		 4y03A-3qw4B:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r11 ENZYME OF ENOLASE
SUPERFAMILY

(Francisella
philomiragia) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A  76
LEU A  81
ALA A 108
ILE A 105
 None
 0.80A 4y03A-3r11A:
undetectable		 4y03A-3r11A:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3skv SSFX3

(Streptomyces
sp. SF2575) 		PF13472
(Lipase_GDSL_2) 		4 ILE A 228
LEU A 203
ALA A 217
ILE A 257
 None
 0.82A 4y03A-3skvA:
undetectable		 4y03A-3skvA:
15.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tlp PROTEIN POLYBROMO-1

(Homo sapiens) 		PF00439
(Bromodomain) 		4 TYR A 526
MET A 561
ALA A 565
ASN A 569
 None
 0.37A 4y03A-3tlpA:
19.8		 4y03A-3tlpA:
37.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tp9 BETA-LACTAMASE AND
RHODANESE DOMAIN
PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF00581
(Rhodanese)
PF00753
(Lactamase_B) 		4 ILE A 326
LEU A 304
ALA A 316
ILE A 347
 None
 0.82A 4y03A-3tp9A:
undetectable		 4y03A-3tp9A:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vis ESTERASE

(Thermobifida
alba) 		PF12740
(Chlorophyllase2) 		4 ILE A 210
ALA A 249
ASN A 254
ILE A 257
 None
 0.83A 4y03A-3visA:
undetectable		 4y03A-3visA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vyg THIOCYANATE
HYDROLASE SUBUNIT
ALPHA

(Thiobacillus
thioparus) 		PF02211
(NHase_beta) 		4 ILE A  94
LEU A 114
TYR A  59
ILE A 118
 None
 0.78A 4y03A-3vygA:
undetectable		 4y03A-3vygA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB

(Pseudomonas
aeruginosa) 		PF00873
(ACR_tran) 		4 ILE A 291
LEU A 293
ALA A 303
ILE A 306
 None
 0.79A 4y03A-3w9iA:
2.3		 4y03A-3w9iA:
7.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE

(Methanocaldococcus
jannaschii) 		PF00464
(SHMT) 		4 ILE A 319
MET A 386
ALA A 390
ILE A 325
 None
 0.81A 4y03A-4bhdA:
undetectable		 4y03A-4bhdA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cg1 CUTINASE

(Thermobifida
fusca) 		PF12740
(Chlorophyllase2) 		4 ILE A 171
ALA A 210
ASN A 215
ILE A 218
 None
 0.87A 4y03A-4cg1A:
undetectable		 4y03A-4cg1A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e6u ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE

(Acinetobacter
baumannii) 		PF00132
(Hexapep)
PF13720
(Acetyltransf_11) 		4 ILE A 235
LEU A 214
TYR A 183
ILE A 250
 None
 0.80A 4y03A-4e6uA:
undetectable		 4y03A-4e6uA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmz INTERNALIN

(Listeria
monocytogenes) 		PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13855
(LRR_8) 		5 ILE A 225
LEU A 215
ALA A 239
ASN A 242
ILE A 244
 None
 1.35A 4y03A-4fmzA:
undetectable		 4y03A-4fmzA:
16.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hbx BROMODOMAIN-CONTAINI
NG PROTEIN 4

(Homo sapiens) 		PF00439
(Bromodomain) 		4 TYR A  97
MET A 132
ASN A 140
ILE A 146
 None
None
14X  A 201 (-3.1A)
14X  A 201 ( 4.0A)
 0.53A 4y03A-4hbxA:
14.3		 4y03A-4hbxA:
31.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4im4 ENDOGLUCANASE E

(Ruminiclostridium
thermocellum) 		PF00150
(Cellulase) 		5 ILE A 301
LEU A 294
TYR A 335
ALA A 269
ILE A 267
 None
 1.03A 4y03A-4im4A:
undetectable		 4y03A-4im4A:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7o PUTATIVE SURFACE
CELL ANTIGEN SCA2

(Rickettsia
conorii) 		no annotation 4 LEU A 248
TYR A 263
ALA A 232
ILE A 228
 None
 0.84A 4y03A-4j7oA:
undetectable		 4y03A-4j7oA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jg5 PUTATIVE CELL
ADHESION PROTEIN

(Parabacteroides
distasonis) 		PF06321
(P_gingi_FimA) 		4 ILE A 194
LEU A 356
ALA A 283
ILE A 210
 None
 0.85A 4y03A-4jg5A:
undetectable		 4y03A-4jg5A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jjp PHOSPHOMETHYLPYRIMID
INE KINASE

(Clostridioides
difficile) 		PF08543
(Phos_pyr_kin) 		4 ILE A 137
LEU A 215
ALA A 232
ILE A 229
 None
 0.76A 4y03A-4jjpA:
undetectable		 4y03A-4jjpA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpp PUTATIVE
UNCHARACTERIZED
PROTEIN

(Archaeoglobus
fulgidus) 		PF01699
(Na_Ca_ex) 		4 ILE A 122
MET A 275
ALA A 262
ILE A 263
 None
 0.79A 4y03A-4kppA:
undetectable		 4y03A-4kppA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4le1 TRANSCRIPTIONAL
REGULATORY PROTEIN
DESR

(Bacillus
subtilis) 		PF00072
(Response_reg) 		4 ILE A   4
LEU A  17
ALA A 110
ILE A 113
 None
 0.84A 4y03A-4le1A:
undetectable		 4y03A-4le1A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mrq PHOSPHOMANNOMUTASE/P
HOSPHOGLUCOMUTASE

(Pseudomonas
aeruginosa) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 ILE A  19
LEU A 126
ALA A  38
ILE A  35
 None
 0.80A 4y03A-4mrqA:
undetectable		 4y03A-4mrqA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4my5 PUTATIVE AMINO ACID
AMINOTRANSFERASE

(Streptococcus
mutans) 		PF00155
(Aminotran_1_2) 		4 ILE A 303
LEU A 382
ALA A 325
ILE A 323
 None
 0.78A 4y03A-4my5A:
undetectable		 4y03A-4my5A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n3w CREB-BINDING PROTEIN

(Homo sapiens) 		PF00439
(Bromodomain)
PF06001
(DUF902) 		4 TYR A1125
MET A1160
ALA A1164
ASN A1168
 None
 0.58A 4y03A-4n3wA:
12.3		 4y03A-4n3wA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ndw NUCLEOID-ASSOCIATED
PROTEIN ESPR

(Mycobacterium
tuberculosis) 		no annotation 4 LEU A   9
MET A  61
ALA A  65
ILE A  70
 None
 0.75A 4y03A-4ndwA:
undetectable		 4y03A-4ndwA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4okq HUT OPERON POSITIVE
REGULATORY PROTEIN

(Geobacillus
thermodenitrificans) 		PF09021
(HutP) 		4 ILE A  55
LEU A 103
ALA A  83
ILE A  80
 None
 0.71A 4y03A-4okqA:
undetectable		 4y03A-4okqA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovt TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Ochrobactrum
anthropi) 		PF03480
(DctP) 		4 ILE A 151
MET A 183
ALA A 185
ILE A 168
 None
 0.75A 4y03A-4ovtA:
undetectable		 4y03A-4ovtA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pkl BROMODOMAIN FACTOR 2

(Trypanosoma
brucei) 		PF00439
(Bromodomain) 		4 TYR A  43
MET A  78
ALA A  82
ASN A  86
 None
None
None
1GH  A 201 ( 3.0A)
 0.38A 4y03A-4pklA:
13.7		 4y03A-4pklA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pmd ENDO-1,4-BETA-XYLANA
SE

(Caldicellulosiruptor
bescii) 		PF00331
(Glyco_hydro_10) 		4 ILE A  39
LEU A  13
ALA A  25
ILE A 299
 None
 0.77A 4y03A-4pmdA:
undetectable		 4y03A-4pmdA:
17.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4q0n PROTEIN POLYBROMO-1

(Homo sapiens) 		PF00439
(Bromodomain) 		7 ILE A 651
LEU A 655
TYR A 664
MET A 699
ALA A 703
ASN A 707
ILE A 713
 2XD  A 802 ( 4.8A)
2XD  A 802 ( 4.3A)
2XD  A 802 (-4.4A)
2XD  A 802 ( 4.3A)
2XD  A 802 (-3.4A)
2XD  A 802 (-3.4A)
2XD  A 802 (-4.6A)
 0.51A 4y03A-4q0nA:
22.1		 4y03A-4q0nA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q5t LIPOPROTEIN

(Streptococcus
mutans) 		PF03180
(Lipoprotein_9) 		4 ILE A  83
LEU A  61
ALA A 251
ILE A 252
 None
 0.76A 4y03A-4q5tA:
undetectable		 4y03A-4q5tA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ru5 TAILSPIKE GP27

(Pseudomonas
phage phi297) 		no annotation 5 ILE A 546
LEU A 610
MET A 597
ALA A 562
ILE A 529
 None
 1.44A 4y03A-4ru5A:
undetectable		 4y03A-4ru5A:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tkd HOLLIDAY JUNCTION
RESOLVASE HJC

(Sulfolobus
solfataricus) 		PF01870
(Hjc) 		4 ILE A  15
LEU A 125
ALA A  45
ILE A  43
 None
 0.76A 4y03A-4tkdA:
undetectable		 4y03A-4tkdA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tpn PUTATIVE P450-LIKE
PROTEIN

(Streptomyces
scabiei) 		PF00067
(p450) 		4 ILE A 129
LEU A 125
ALA A 141
ILE A 136
 None
 0.82A 4y03A-4tpnA:
undetectable		 4y03A-4tpnA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uyd BROMODOMAIN-CONTAINI
NG PROTEIN 4

(Homo sapiens) 		PF00439
(Bromodomain) 		4 TYR A  97
MET A 132
ASN A 140
ILE A 146
 None
None
V1T  A1171 (-3.1A)
DMS  A1169 ( 4.3A)
 0.51A 4y03A-4uydA:
14.4		 4y03A-4uydA:
27.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		4 ILE A 371
LEU A 364
ALA A 443
ILE A 440
 None
 0.76A 4y03A-4wziA:
undetectable		 4y03A-4wziA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgo ANOPHELES
PLASMODIUM-RESPONSIV
E LEUCINE-RICH
REPEAT PROTEIN 1B

(Anopheles
gambiae) 		PF13855
(LRR_8) 		4 LEU A 156
ALA A 186
ASN A 189
ILE A 191
 None
 0.82A 4y03A-4xgoA:
undetectable		 4y03A-4xgoA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xz8 NUCLEOPROTEIN

(Thiafora
orthonairovirus) 		PF02477
(Nairo_nucleo) 		4 ILE A 390
TYR A 459
ALA A  75
ILE A  77
 None
 0.78A 4y03A-4xz8A:
2.5		 4y03A-4xz8A:
14.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4z6i BROMODOMAIN-CONTAINI
NG PROTEIN 9

(Homo sapiens) 		PF00439
(Bromodomain) 		4 TYR A  57
MET A  92
ALA A  96
ASN A 100
 None
None
4L3  A 201 ( 4.8A)
4L3  A 201 (-3.2A)
 0.32A 4y03A-4z6iA:
15.1		 4y03A-4z6iA:
30.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a55 ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		4 ILE A 377
MET A 408
ALA A 406
ILE A 404
 None
 0.77A 4y03A-5a55A:
undetectable		 4y03A-5a55A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3g PROTEIN SHORT-ROOT

(Arabidopsis
thaliana) 		PF03514
(GRAS) 		4 ILE B 385
TYR B 482
ALA B 242
ILE B 246
 None
 0.84A 4y03A-5b3gB:
undetectable		 4y03A-5b3gB:
13.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5c4q BROMODOMAIN

(Leishmania
donovani) 		PF00439
(Bromodomain) 		4 TYR A  44
MET A  79
ALA A  83
ASN A  87
 BMF  A 201 ( 4.9A)
None
BMF  A 201 ( 4.1A)
BMF  A 201 (-2.8A)
 0.32A 4y03A-5c4qA:
13.3		 4y03A-5c4qA:
31.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cm2 TRNA
METHYLTRANSFERASE

(Yarrowia
lipolytica) 		PF08241
(Methyltransf_11) 		4 ILE Z 141
LEU Z 145
ALA Z 227
ILE Z 153
 None
 0.85A 4y03A-5cm2Z:
undetectable		 4y03A-5cm2Z:
20.30