SIMILAR PATTERNS OF AMINO ACIDS FOR 4XZK_A_AG2A700

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ffv CUTL, MOLYBDOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE


(Hydrogenophaga
pseudoflava)
PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2)
4 SER B 386
SER B 564
GLU B 482
GLU B 757
CSZ  B 385 ( 3.5A)
PCD  B1920 (-4.0A)
None
PCD  B1920 (-3.2A)
1.12A 4xzkA-1ffvB:
undetectable
4xzkA-1ffvB:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hzh IMMUNOGLOBULIN HEAVY
CHAIN


(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
4 SER H 280
TYR H 319
SER H 317
GLU H 282
None
1.26A 4xzkA-1hzhH:
undetectable
4xzkA-1hzhH:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lt3 HEAT-LABILE
ENTEROTOXIN


(Escherichia
coli)
PF01375
(Enterotoxin_a)
4 ARG A   7
SER A  61
GLU A 110
GLU A 112
None
0.70A 4xzkA-1lt3A:
3.4
4xzkA-1lt3A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN


(Oligotropha
carboxidovorans)
PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2)
4 SER B 389
SER B 570
GLU B 488
GLU B 763
None
MCN  B4920 (-4.3A)
None
OMO  B4921 ( 3.3A)
1.18A 4xzkA-1n60B:
0.0
4xzkA-1n60B:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2


(Synechocystis
sp. PCC 6803)
PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central)
4 ARG A1160
SER A 881
PHE A1163
GLU A1135
None
1.23A 4xzkA-1ofeA:
undetectable
4xzkA-1ofeA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qs1 ADP-RIBOSYLTRANSFERA
SE


(Bacillus cereus)
PF03496
(ADPrib_exo_Tox)
4 SER A 425
ARG A 349
SER A 386
GLU A 428
None
1.39A 4xzkA-1qs1A:
12.0
4xzkA-1qs1A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjo ALANINE--GLYOXYLATE
AMINOTRANSFERASE


(Nostoc sp. PCC
7120)
PF00266
(Aminotran_5)
4 TYR A 107
ARG A 356
SER A 159
GLU A 157
None
1.12A 4xzkA-1vjoA:
undetectable
4xzkA-1vjoA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcg THIOGLUCOSIDASE

(Brevicoryne
brassicae)
PF00232
(Glyco_hydro_1)
4 ARG A 252
SER A 226
GLU A 374
GLU A 167
None
None
GOL  A1465 (-2.6A)
GOL  A1466 ( 3.1A)
1.28A 4xzkA-1wcgA:
undetectable
4xzkA-1wcgA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkp CHAPERONE PROTEIN
SYCN
PUTATIVE
MEMBRANE-BOUND YOP
TARGETING PROTEIN
YOPN


(Yersinia pestis)
PF07201
(HrpJ)
no annotation
4 SER B  34
ARG A  35
PHE B 110
GLU A  37
None
1.46A 4xzkA-1xkpB:
undetectable
4xzkA-1xkpB:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a30 DEOXYCYTIDINE KINASE

(Homo sapiens)
PF01712
(dNK)
4 SER A 132
TYR A 131
SER A  25
GLU A  27
None
1.46A 4xzkA-2a30A:
undetectable
4xzkA-2a30A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bi7 UDP-GALACTOPYRANOSE
MUTASE


(Klebsiella
pneumoniae)
PF03275
(GLF)
PF13450
(NAD_binding_8)
4 TYR A 259
SER A 296
PHE A 257
GLU A 283
None
1.21A 4xzkA-2bi7A:
undetectable
4xzkA-2bi7A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eba PUTATIVE
GLUTARYL-COA
DEHYDROGENASE


(Thermus
thermophilus)
PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
4 SER A 225
SER A 109
PHE A 116
GLU A 111
None
1.36A 4xzkA-2ebaA:
undetectable
4xzkA-2ebaA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f3o PYRUVATE
FORMATE-LYASE 2


(Archaeoglobus
fulgidus)
PF01228
(Gly_radical)
PF02901
(PFL-like)
4 SER A 502
SER A 438
PHE A 625
GLU A 149
None
1.25A 4xzkA-2f3oA:
undetectable
4xzkA-2f3oA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h1t HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa)
PF06475
(Glycolipid_bind)
4 SER A  32
SER A 107
PHE A 109
GLU A  21
None
1.42A 4xzkA-2h1tA:
undetectable
4xzkA-2h1tA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ixs SDAI RESTRICTION
ENDONUCLEASE


(Streptomyces
diastaticus)
PF06616
(BsuBI_PstI_RE)
4 SER A 128
TYR A 129
ARG A 157
PHE A  24
None
EPE  A1329 (-4.6A)
EPE  A1329 ( 4.7A)
None
1.29A 4xzkA-2ixsA:
undetectable
4xzkA-2ixsA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3z C2 TOXIN COMPONENT I

(Clostridium
botulinum)
PF03496
(ADPrib_exo_Tox)
4 TYR A 257
ARG A 299
SER A 348
GLU A 389
GOL  A1435 (-3.4A)
SO4  A1438 (-3.3A)
GOL  A1435 ( 3.0A)
GOL  A1435 (-3.4A)
0.81A 4xzkA-2j3zA:
12.4
4xzkA-2j3zA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jeo URIDINE-CYTIDINE
KINASE 1


(Homo sapiens)
PF00485
(PRK)
4 SER A  37
ARG A  66
SER A  63
GLU A 138
None
1.40A 4xzkA-2jeoA:
undetectable
4xzkA-2jeoA:
26.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6r VARIABLE LYMPHOCYTE
RECEPTOR B


(Eptatretus
burgeri)
PF01462
(LRRNT)
PF11921
(DUF3439)
PF13855
(LRR_8)
4 SER A  83
TYR A 105
ARG A  55
GLU A  59
None
1.43A 4xzkA-2o6rA:
undetectable
4xzkA-2o6rA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8r POLYPHOSPHATE KINASE

(Porphyromonas
gingivalis)
PF02503
(PP_kinase)
PF13089
(PP_kinase_N)
PF13090
(PP_kinase_C)
4 SER A 473
TYR A 592
ARG A 675
GLU A 594
None
1.30A 4xzkA-2o8rA:
undetectable
4xzkA-2o8rA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR


(Cryptosporidium
hominis)
PF00186
(DHFR_1)
PF00303
(Thymidylat_synt)
4 SER A 437
TYR A 438
PHE A 298
GLU A 294
None
None
None
CB3  A 604 ( 3.8A)
1.41A 4xzkA-2oipA:
undetectable
4xzkA-2oipA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pka KALLIKREIN A

(Sus scrofa)
PF00089
(Trypsin)
4 SER A  38
ARG A  70
PHE A  82
GLU A  64
None
1.33A 4xzkA-2pkaA:
undetectable
4xzkA-2pkaA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qpm CYTOKININ
DEHYDROGENASE 1


(Zea mays)
PF01565
(FAD_binding_4)
PF09265
(Cytokin-bind)
4 SER A 185
PHE A 374
GLU A 331
GLU A 288
None
1.13A 4xzkA-2qpmA:
undetectable
4xzkA-2qpmA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r39 FIXG-RELATED PROTEIN

(Vibrio
parahaemolyticus)
PF11614
(FixG_C)
4 SER A 449
TYR A 404
PHE A 483
GLU A 401
None
1.46A 4xzkA-2r39A:
undetectable
4xzkA-2r39A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN


(Staphylococcus
haemolyticus)
PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5)
4 SER B 281
ARG B 287
SER B 313
GLU B 283
None
1.47A 4xzkA-2rhqB:
undetectable
4xzkA-2rhqB:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2tdd THYMIDYLATE SYNTHASE

(Lactobacillus
casei)
PF00303
(Thymidylat_synt)
4 SER A 232
TYR A 233
PHE A  64
GLU A  60
None
1.32A 4xzkA-2tddA:
undetectable
4xzkA-2tddA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wab ENDOGLUCANASE E

(Ruminiclostridium
thermocellum)
PF00657
(Lipase_GDSL)
4 SER A  98
SER A 176
PHE A 147
GLU A  96
BGC  A1339 ( 4.0A)
BGC  A1339 (-4.5A)
BGC  A1339 ( 3.7A)
BGC  A1339 ( 4.0A)
1.47A 4xzkA-2wabA:
undetectable
4xzkA-2wabA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wed PENICILLOPEPSIN

(Penicillium
janthinellum)
PF00026
(Asp)
4 SER A  43
TYR A  57
PHE A  86
GLU A  45
None
1.21A 4xzkA-2wedA:
undetectable
4xzkA-2wedA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wn4 ADP-RIBOSYLTRANSFERA
SE ENZYMATIC
COMPONENT


(Clostridioides
difficile)
PF03496
(ADPrib_exo_Tox)
4 TYR A 258
ARG A 302
SER A 345
GLU A 387
None
0.62A 4xzkA-2wn4A:
15.0
4xzkA-2wn4A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME


(Homo sapiens)
PF01401
(Peptidase_M2)
4 SER A 147
TYR A 146
SER A 516
GLU A 143
None
0.90A 4xzkA-2xy9A:
undetectable
4xzkA-2xy9A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynm LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N


(Prochlorococcus
marinus)
PF00148
(Oxidored_nitro)
4 SER C 133
SER C 105
GLU C 138
GLU C 106
None
1.43A 4xzkA-2ynmC:
undetectable
4xzkA-2ynmC:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yrr AMINOTRANSFERASE,
CLASS V


(Thermus
thermophilus)
PF00266
(Aminotran_5)
4 SER A  86
ARG A 326
SER A 136
GLU A 134
None
1.30A 4xzkA-2yrrA:
undetectable
4xzkA-2yrrA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1n NDP-SUGAR EPIMERASE

(Thermoplasma
volcanium)
PF01370
(Epimerase)
4 ARG A 163
SER A 127
GLU A 285
GLU A 281
None
1.13A 4xzkA-3a1nA:
undetectable
4xzkA-3a1nA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3buz IOTA TOXIN COMPONENT
IA


(Clostridium
perfringens)
PF03496
(ADPrib_exo_Tox)
4 ARG A 295
SER A 338
GLU A 378
GLU A 380
TAD  A 500 (-3.2A)
TAD  A 500 (-3.2A)
None
TAD  A 500 (-2.6A)
0.87A 4xzkA-3buzA:
10.4
4xzkA-3buzA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3buz IOTA TOXIN COMPONENT
IA


(Clostridium
perfringens)
PF03496
(ADPrib_exo_Tox)
4 TYR A 251
ARG A 295
SER A 338
GLU A 380
TAD  A 500 (-4.1A)
TAD  A 500 (-3.2A)
TAD  A 500 (-3.2A)
TAD  A 500 (-2.6A)
0.62A 4xzkA-3buzA:
10.4
4xzkA-3buzA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3di4 UNCHARACTERIZED
PROTEIN DUF1989


(Ruegeria
pomeroyi)
PF09347
(DUF1989)
4 SER A  71
TYR A 221
PHE A 261
GLU A 259
None
1.40A 4xzkA-3di4A:
undetectable
4xzkA-3di4A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwl ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 1
ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 4


(Schizosaccharomyces
pombe)
PF00400
(WD40)
PF05856
(ARPC4)
4 SER C 147
SER F  43
PHE F  25
GLU F  45
None
1.40A 4xzkA-3dwlC:
undetectable
4xzkA-3dwlC:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ffr PHOSPHOSERINE
AMINOTRANSFERASE
SERC


(Cytophaga
hutchinsonii)
PF00266
(Aminotran_5)
4 SER A  94
ARG A 337
SER A 141
GLU A 139
None
1.31A 4xzkA-3ffrA:
undetectable
4xzkA-3ffrA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fnb ACYLAMINOACYL
PEPTIDASE SMU_737


(Streptococcus
mutans)
PF12146
(Hydrolase_4)
4 ARG A  97
PHE A 114
GLU A 118
GLU A 170
None
1.33A 4xzkA-3fnbA:
undetectable
4xzkA-3fnbA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3git CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA


(Moorella
thermoacetica)
PF03598
(CdhC)
4 TYR A 413
PHE A 410
GLU A 455
GLU A 454
None
1.40A 4xzkA-3gitA:
undetectable
4xzkA-3gitA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 15
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 3


(Thermus
thermophilus)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4)
PF10588
(NADH-G_4Fe-4S_3)
PF11497
(NADH_Oxid_Nqo15)
PF13510
(Fer2_4)
4 SER 7  58
ARG 3 178
GLU 7  32
GLU 7  34
None
None
CA  3 790 ( 3.4A)
CA  3 790 ( 4.3A)
1.34A 4xzkA-3i9v7:
undetectable
4xzkA-3i9v7:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jux PROTEIN TRANSLOCASE
SUBUNIT SECA


(Thermotoga
maritima)
PF00271
(Helicase_C)
PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD)
4 SER A 375
TYR A 374
ARG A 302
GLU A 768
None
1.29A 4xzkA-3juxA:
undetectable
4xzkA-3juxA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ke3 PUTATIVE
SERINE-PYRUVATE
AMINOTRANSFERASE


(Psychrobacter
arcticus)
PF00266
(Aminotran_5)
4 SER A  85
ARG A 349
SER A 146
GLU A 144
None
ACT  A 380 (-3.1A)
None
None
1.20A 4xzkA-3ke3A:
undetectable
4xzkA-3ke3A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ld8 BIFUNCTIONAL
ARGININE DEMETHYLASE
AND
LYSYL-HYDROXYLASE
JMJD6


(Homo sapiens)
PF02373
(JmjC)
4 SER A 290
SER A 194
PHE A 266
GLU A  64
None
1.46A 4xzkA-3ld8A:
undetectable
4xzkA-3ld8A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxq UNCHARACTERIZED
PROTEIN VP1736


(Vibrio
parahaemolyticus)
PF00884
(Sulfatase)
4 SER A 635
TYR A 638
ARG A 349
SER A 348
None
1.20A 4xzkA-3lxqA:
undetectable
4xzkA-3lxqA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ndh RESTRICTION
ENDONUCLEASE THAI


(Thermoplasma
acidophilum)
PF15514
(ThaI)
4 TYR A 160
SER A 176
GLU A 182
GLU A 178
None
1.21A 4xzkA-3ndhA:
undetectable
4xzkA-3ndhA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o1h PERIPLASMIC PROTEIN
TORT


(Vibrio
parahaemolyticus)
PF00532
(Peripla_BP_1)
4 SER B 254
TYR B 252
SER B 250
GLU B 231
None
0.89A 4xzkA-3o1hB:
undetectable
4xzkA-3o1hB:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o6x GLUTAMINE SYNTHETASE

(Bacteroides
fragilis)
PF00120
(Gln-synt_C)
PF12437
(GSIII_N)
4 SER A 540
PHE A 534
GLU A 546
GLU A 542
None
1.44A 4xzkA-3o6xA:
undetectable
4xzkA-3o6xA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3otr ENOLASE

(Toxoplasma
gondii)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
4 ARG A  16
SER A 385
GLU A 174
GLU A 217
None
1.42A 4xzkA-3otrA:
undetectable
4xzkA-3otrA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rc0 N-LYSINE
METHYLTRANSFERASE
SETD6


(Homo sapiens)
PF00856
(SET)
PF09273
(Rubis-subs-bind)
4 SER A 104
ARG A 141
SER A 138
GLU A 132
None
1.35A 4xzkA-3rc0A:
undetectable
4xzkA-3rc0A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s8d COENZYME A
TRANSFERASE


(Yersinia pestis)
PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C)
4 TYR A 108
SER A  83
PHE A  85
GLU A  90
None
1.36A 4xzkA-3s8dA:
undetectable
4xzkA-3s8dA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0j TYPE III EFFECTOR
HOPU1


(Pseudomonas
syringae group
genomosp. 3)
no annotation 4 ARG B 164
SER B 193
GLU B 233
GLU B 235
None
0.81A 4xzkA-3u0jB:
14.0
4xzkA-3u0jB:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4j NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE


(Sinorhizobium
meliloti)
PF00171
(Aldedh)
4 ARG A 307
SER A 306
PHE A 426
GLU A 400
None
1.37A 4xzkA-3u4jA:
2.2
4xzkA-3u4jA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vbe BETA-CYANOALNINE
SYNTHASE


(Glycine max)
PF00291
(PALP)
4 SER A 151
ARG A 361
SER A 353
GLU A 153
None
1.39A 4xzkA-3vbeA:
undetectable
4xzkA-3vbeA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vom PUTATIVE
PHOSPHOSERINE
AMINOTRANSFERASE


(Mycobacterium
tuberculosis)
PF00266
(Aminotran_5)
4 SER A 109
ARG A 350
SER A 155
GLU A 153
None
1.37A 4xzkA-3vomA:
undetectable
4xzkA-3vomA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w3s TYPE-2 SERINE--TRNA
LIGASE


(Methanopyrus
kandleri)
PF00587
(tRNA-synt_2b)
4 SER A 405
ARG A 485
SER A 449
GLU A 430
None
SSA  A2002 ( 3.7A)
SSA  A2002 (-3.1A)
None
1.41A 4xzkA-3w3sA:
undetectable
4xzkA-3w3sA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wky PROPHENOLOXIDASE B

(Marsupenaeus
japonicus)
PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C)
4 SER A 617
ARG A 547
SER A 552
GLU A 529
None
1.24A 4xzkA-3wkyA:
undetectable
4xzkA-3wkyA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wnb PROTEIN TRANSLATION
ELONGATION FACTOR 1A


(Methanosarcina
mazei)
no annotation 4 SER A 327
SER A 254
PHE A 176
GLU A 257
None
1.33A 4xzkA-3wnbA:
undetectable
4xzkA-3wnbA:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aut DECAPRENYL-PHOSPHORY
L-BETA-D-RIBOFURANOS
E-2-OXIDOREDUCTASE


(Mycolicibacterium
smegmatis)
PF01565
(FAD_binding_4)
PF04030
(ALO)
4 SER A 234
TYR A 231
PHE A 222
GLU A 228
None
1.44A 4xzkA-4autA:
undetectable
4xzkA-4autA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata)
PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s)
4 ARG A 775
PHE A 773
GLU A 599
GLU A 595
None
1.31A 4xzkA-4bedA:
undetectable
4xzkA-4bedA:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cu8 GLYCOSIDE HYDROLASE
2


(Streptococcus
pneumoniae)
PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982)
4 SER A 625
TYR A 624
ARG A 481
SER A 644
None
EDO  A2021 ( 4.4A)
None
None
1.43A 4xzkA-4cu8A:
undetectable
4xzkA-4cu8A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dnh UNCHARACTERIZED
PROTEIN


(Sinorhizobium
meliloti)
PF06187
(DUF993)
4 SER A 104
ARG A  88
SER A  82
GLU A  81
None
1.42A 4xzkA-4dnhA:
undetectable
4xzkA-4dnhA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fvv NEUROTOXIN

(Clostridium
botulinum)
PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N)
4 SER A1242
ARG A1253
SER A1244
GLU A1255
None
SO4  A1303 (-3.7A)
None
None
1.43A 4xzkA-4fvvA:
undetectable
4xzkA-4fvvA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fvv NEUROTOXIN

(Clostridium
botulinum)
PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N)
4 SER A1242
TYR A1243
ARG A1184
GLU A1255
None
1.39A 4xzkA-4fvvA:
undetectable
4xzkA-4fvvA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i62 AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING
PROTEIN, PUTATIVE


(Streptococcus
pneumoniae)
PF00497
(SBP_bac_3)
4 SER A 109
SER A 158
PHE A  48
GLU A 197
ARG  A 301 (-2.8A)
ARG  A 301 (-4.8A)
ARG  A 301 (-3.4A)
ARG  A 301 (-2.7A)
1.20A 4xzkA-4i62A:
undetectable
4xzkA-4i62A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iqq THYMIDYLATE SYNTHASE

(Caenorhabditis
elegans)
PF00303
(Thymidylat_synt)
4 SER A 231
TYR A 232
PHE A  93
GLU A  89
None
1.43A 4xzkA-4iqqA:
undetectable
4xzkA-4iqqA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4itx CYSTATHIONINE
BETA-LYASE METC


(Escherichia
coli)
PF01053
(Cys_Met_Meta_PP)
4 TYR A 111
ARG A 372
SER A 158
GLU A 154
IN5  A 401 (-3.6A)
IN5  A 401 (-2.9A)
IN5  A 401 ( 4.0A)
IN5  A 401 (-3.7A)
1.28A 4xzkA-4itxA:
undetectable
4xzkA-4itxA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nhy 2-OXOGLUTARATE AND
IRON-DEPENDENT
OXYGENASE
DOMAIN-CONTAINING
PROTEIN 1


(Homo sapiens)
PF10637
(Ofd1_CTDD)
PF13661
(2OG-FeII_Oxy_4)
4 SER A 142
ARG A 230
SER A 232
PHE A  98
None
PD2  A 603 (-2.6A)
PD2  A 603 (-3.1A)
None
1.38A 4xzkA-4nhyA:
undetectable
4xzkA-4nhyA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nre ARACHIDONATE
15-LIPOXYGENASE B


(Homo sapiens)
PF00305
(Lipoxygenase)
PF01477
(PLAT)
4 SER A 675
TYR A 408
GLU A 613
GLU A 671
GOL  A 718 ( 4.6A)
SO4  A 710 (-4.8A)
GOL  A 718 (-3.3A)
GOL  A 718 ( 4.8A)
1.48A 4xzkA-4nreA:
undetectable
4xzkA-4nreA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oua LATENT FORM OF PPO4
TYROSINASE


(Agaricus
bisporus)
PF00264
(Tyrosinase)
4 SER B 311
TYR B  75
ARG B 466
GLU B 307
None
1.42A 4xzkA-4ouaB:
undetectable
4xzkA-4ouaB:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pn0 MRNA-CAPPING ENZYME
SUBUNIT BETA


(Schizosaccharomyces
pombe)
PF02940
(mRNA_triPase)
4 ARG A 203
SER A 205
GLU A 260
GLU A  80
None
1.32A 4xzkA-4pn0A:
undetectable
4xzkA-4pn0A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q8k ALGINASE

(Pseudoalteromonas
sp. SM0524)
PF08787
(Alginate_lyase2)
4 TYR A 270
SER A 272
PHE A 279
GLU A 276
SO4  A 502 (-4.8A)
None
None
SO4  A 502 ( 4.7A)
1.39A 4xzkA-4q8kA:
undetectable
4xzkA-4q8kA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q8l ALGINASE

(Pseudoalteromonas
sp. SM0524)
PF08787
(Alginate_lyase2)
4 TYR A 103
SER A 105
PHE A 112
GLU A 109
None
1.40A 4xzkA-4q8lA:
undetectable
4xzkA-4q8lA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u48 PUTATIVE INNER
MEMBRANE LIPOPROTEIN


(Salmonella
enterica)
PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl)
PF11974
(MG1)
4 SER A1415
ARG A1363
SER A1375
GLU A1418
None
1.30A 4xzkA-4u48A:
undetectable
4xzkA-4u48A:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgk UDP-GALACTOPYRANOSE
MUTASE


(Corynebacterium
diphtheriae)
PF03275
(GLF)
PF13450
(NAD_binding_8)
4 TYR A 325
ARG A 316
PHE A 261
GLU A 313
FDA  A 403 (-4.2A)
None
None
None
1.33A 4xzkA-4xgkA:
undetectable
4xzkA-4xgkA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ypj BETA GALACTOSIDASE

(Bacillus
circulans)
PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982)
4 SER A 512
TYR A 511
ARG A 376
SER A 531
None
1.45A 4xzkA-4ypjA:
undetectable
4xzkA-4ypjA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ys4 MEROZOITE SURFACE
PROTEIN P41


(Plasmodium
falciparum)
PF07422
(s48_45)
4 TYR A 328
SER A 325
PHE A 286
GLU A 288
None
None
GOL  A 406 ( 3.7A)
None
1.28A 4xzkA-4ys4A:
undetectable
4xzkA-4ys4A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzw AGAP004976-PA

(Anopheles
gambiae)
PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C)
4 TYR A 640
ARG A 561
SER A 566
GLU A 544
None
1.33A 4xzkA-4yzwA:
undetectable
4xzkA-4yzwA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ziu UNCHARACTERIZED
LIPOPROTEIN YFHM


(Escherichia
coli)
PF07678
(A2M_comp)
4 SER A1424
ARG A1371
SER A1384
GLU A1427
None
1.27A 4xzkA-4ziuA:
undetectable
4xzkA-4ziuA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a08 PROBABLE
MANNOSYLTRANSFERASE
KTR4


(Saccharomyces
cerevisiae)
PF01793
(Glyco_transf_15)
4 SER A 457
SER A 399
GLU A 459
GLU A 460
None
1.17A 4xzkA-5a08A:
undetectable
4xzkA-5a08A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a42 UNCHARACTERIZED
LIPOPROTEIN YFHM


(Escherichia
coli)
PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF11974
(MG1)
4 SER A1424
ARG A1371
SER A1384
GLU A1427
None
1.33A 4xzkA-5a42A:
undetectable
4xzkA-5a42A:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a6f GATING RING OF
POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1


(Gallus gallus)
PF03493
(BK_channel_a)
4 SER C 536
TYR C 532
PHE C 933
GLU C 520
None
1.26A 4xzkA-5a6fC:
undetectable
4xzkA-5a6fC:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dm3 L-GLUTAMINE
SYNTHETASE


(Chromohalobacter
salexigens)
PF00120
(Gln-synt_C)
4 ARG A 315
SER A 260
GLU A 206
GLU A 145
None
1.27A 4xzkA-5dm3A:
undetectable
4xzkA-5dm3A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5edu MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HISTONE DEACETYLASE
6 CHIMERA


(Escherichia
coli;
Homo sapiens)
no annotation 4 SER B 479
TYR B 449
ARG B 174
SER B 445
None
None
MAL  B2505 (-3.5A)
None
1.20A 4xzkA-5eduB:
undetectable
4xzkA-5eduB:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gr1 1,4-ALPHA-GLUCAN
BRANCHING ENZYME
GLGB


(Cyanothece sp.
ATCC 51142)
PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48)
4 SER A 339
TYR A 212
SER A 336
GLU A 320
None
1.38A 4xzkA-5gr1A:
undetectable
4xzkA-5gr1A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1


(Mus musculus)
PF00145
(DNA_methylase)
PF01426
(BAH)
4 SER A1094
TYR A1092
SER A1048
GLU A1050
None
1.09A 4xzkA-5gutA:
undetectable
4xzkA-5gutA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h04 BINARY ENTEROTOXIN
OF CLOSTRIDIUM
PERFRINGENS
COMPONENT A


(Clostridium
perfringens)
PF03496
(ADPrib_exo_Tox)
4 TYR A 252
ARG A 297
SER A 340
GLU A 382
NAI  A 501 (-3.4A)
NAI  A 501 (-2.8A)
NAI  A 501 (-2.6A)
NAI  A 501 (-3.1A)
1.16A 4xzkA-5h04A:
15.3
4xzkA-5h04A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h04 BINARY ENTEROTOXIN
OF CLOSTRIDIUM
PERFRINGENS
COMPONENT A


(Clostridium
perfringens)
PF03496
(ADPrib_exo_Tox)
4 TYR A 252
SER A 340
PHE A 351
GLU A 382
NAI  A 501 (-3.4A)
NAI  A 501 (-2.6A)
NAI  A 501 (-4.0A)
NAI  A 501 (-3.1A)
1.32A 4xzkA-5h04A:
15.3
4xzkA-5h04A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hw3 BETA-LACTAMASE

(Burkholderia
vietnamiensis)
PF13354
(Beta-lactamase2)
4 SER A  70
ARG A 165
SER A 170
GLU A 167
SO4  A 301 (-2.7A)
None
None
None
1.32A 4xzkA-5hw3A:
undetectable
4xzkA-5hw3A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA


(Homo sapiens)
PF08332
(CaMKII_AD)
4 TYR A 369
ARG A 433
PHE A 467
GLU A 381
None
1.44A 4xzkA-5ig3A:
undetectable
4xzkA-5ig3A:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kwl VP3

(Enterovirus C)
PF00073
(Rhv)
4 SER 3  86
SER 3  91
PHE 3 184
GLU 3 186
None
1.38A 4xzkA-5kwl3:
undetectable
4xzkA-5kwl3:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkk MULTIDRUG RESISTANCE
ABC TRANSPORTER
ATP-BINDING AND
PERMEASE PROTEIN


(Thermus
thermophilus)
PF00005
(ABC_tran)
PF00664
(ABC_membrane)
4 SER B 425
ARG B 487
PHE B 422
GLU A 218
None
1.20A 4xzkA-5mkkB:
undetectable
4xzkA-5mkkB:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oqm GENERAL
TRANSCRIPTION AND
DNA REPAIR FACTOR
IIH HELICASE SUBUNIT
XPB


(Saccharomyces
cerevisiae)
no annotation 4 SER 7 675
ARG 7 681
SER 7 679
GLU 7 683
None
1.39A 4xzkA-5oqm7:
undetectable
4xzkA-5oqm7:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t0l BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE


(Toxoplasma
gondii)
PF00186
(DHFR_1)
PF00303
(Thymidylat_synt)
4 SER A 524
TYR A 525
PHE A 385
GLU A 381
None
None
None
CB3  A 703 ( 4.1A)
1.27A 4xzkA-5t0lA:
undetectable
4xzkA-5t0lA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj3 ALKALINE PHOSPHATASE
PAFA


(Elizabethkingia
meningoseptica)
PF01663
(Phosphodiest)
4 SER A 315
PHE A 249
GLU A 317
GLU A 238
None
None
ZN  A 603 (-2.3A)
ZN  A 603 (-2.7A)
1.32A 4xzkA-5tj3A:
undetectable
4xzkA-5tj3A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wab PUTATIVE
BETA-GLUCOSIDASE


(Bifidobacterium
adolescentis)
no annotation 4 SER A 254
TYR A 255
SER A  22
GLU A 250
None
1.35A 4xzkA-5wabA:
undetectable
4xzkA-5wabA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 6


(Homo sapiens)
PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF02735
(Ku)
PF03730
(Ku_C)
PF03731
(Ku_N)
PF08163
(NUC194)
4 ARG C 213
SER C 210
GLU A 333
GLU A 332
None
1.22A 4xzkA-5y3rC:
undetectable
4xzkA-5y3rC:
4.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zq6 SIDE

(Legionella
pneumophila)
no annotation 4 SER A 815
PHE A 827
GLU A 855
GLU A 857
None
0.63A 4xzkA-5zq6A:
9.8
4xzkA-5zq6A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6q EXOSOME RNA HELICASE
MTR4


(Homo sapiens)
no annotation 4 SER M 588
TYR M 590
SER M 561
GLU M 267
None
1.25A 4xzkA-6d6qM:
undetectable
4xzkA-6d6qM:
17.96