SIMILAR PATTERNS OF AMINO ACIDS FOR 4XZK_A_AG2A700
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ffv | CUTL, MOLYBDOPROTEINOF CARBON MONOXIDEDEHYDROGENASE (Hydrogenophagapseudoflava) |
PF01315(Ald_Xan_dh_C)PF02738(Ald_Xan_dh_C2) | 4 | SER B 386SER B 564GLU B 482GLU B 757 | CSZ B 385 ( 3.5A)PCD B1920 (-4.0A)NonePCD B1920 (-3.2A) | 1.12A | 4xzkA-1ffvB:undetectable | 4xzkA-1ffvB:14.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hzh | IMMUNOGLOBULIN HEAVYCHAIN (Homo sapiens) |
PF07654(C1-set)PF07686(V-set) | 4 | SER H 280TYR H 319SER H 317GLU H 282 | None | 1.26A | 4xzkA-1hzhH:undetectable | 4xzkA-1hzhH:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lt3 | HEAT-LABILEENTEROTOXIN (Escherichiacoli) |
PF01375(Enterotoxin_a) | 4 | ARG A 7SER A 61GLU A 110GLU A 112 | None | 0.70A | 4xzkA-1lt3A:3.4 | 4xzkA-1lt3A:22.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n60 | CARBON MONOXIDEDEHYDROGENASE LARGECHAIN (Oligotrophacarboxidovorans) |
PF01315(Ald_Xan_dh_C)PF02738(Ald_Xan_dh_C2) | 4 | SER B 389SER B 570GLU B 488GLU B 763 | NoneMCN B4920 (-4.3A)NoneOMO B4921 ( 3.3A) | 1.18A | 4xzkA-1n60B:0.0 | 4xzkA-1n60B:15.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ofe | FERREDOXIN-DEPENDENTGLUTAMATE SYNTHASE 2 (Synechocystissp. PCC 6803) |
PF00310(GATase_2)PF01493(GXGXG)PF01645(Glu_synthase)PF04898(Glu_syn_central) | 4 | ARG A1160SER A 881PHE A1163GLU A1135 | None | 1.23A | 4xzkA-1ofeA:undetectable | 4xzkA-1ofeA:10.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qs1 | ADP-RIBOSYLTRANSFERASE (Bacillus cereus) |
PF03496(ADPrib_exo_Tox) | 4 | SER A 425ARG A 349SER A 386GLU A 428 | None | 1.39A | 4xzkA-1qs1A:12.0 | 4xzkA-1qs1A:18.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vjo | ALANINE--GLYOXYLATEAMINOTRANSFERASE (Nostoc sp. PCC7120) |
PF00266(Aminotran_5) | 4 | TYR A 107ARG A 356SER A 159GLU A 157 | None | 1.12A | 4xzkA-1vjoA:undetectable | 4xzkA-1vjoA:22.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wcg | THIOGLUCOSIDASE (Brevicorynebrassicae) |
PF00232(Glyco_hydro_1) | 4 | ARG A 252SER A 226GLU A 374GLU A 167 | NoneNoneGOL A1465 (-2.6A)GOL A1466 ( 3.1A) | 1.28A | 4xzkA-1wcgA:undetectable | 4xzkA-1wcgA:18.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xkp | CHAPERONE PROTEINSYCNPUTATIVEMEMBRANE-BOUND YOPTARGETING PROTEINYOPN (Yersinia pestis) |
PF07201(HrpJ)no annotation | 4 | SER B 34ARG A 35PHE B 110GLU A 37 | None | 1.46A | 4xzkA-1xkpB:undetectable | 4xzkA-1xkpB:20.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a30 | DEOXYCYTIDINE KINASE (Homo sapiens) |
PF01712(dNK) | 4 | SER A 132TYR A 131SER A 25GLU A 27 | None | 1.46A | 4xzkA-2a30A:undetectable | 4xzkA-2a30A:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bi7 | UDP-GALACTOPYRANOSEMUTASE (Klebsiellapneumoniae) |
PF03275(GLF)PF13450(NAD_binding_8) | 4 | TYR A 259SER A 296PHE A 257GLU A 283 | None | 1.21A | 4xzkA-2bi7A:undetectable | 4xzkA-2bi7A:21.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eba | PUTATIVEGLUTARYL-COADEHYDROGENASE (Thermusthermophilus) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 4 | SER A 225SER A 109PHE A 116GLU A 111 | None | 1.36A | 4xzkA-2ebaA:undetectable | 4xzkA-2ebaA:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f3o | PYRUVATEFORMATE-LYASE 2 (Archaeoglobusfulgidus) |
PF01228(Gly_radical)PF02901(PFL-like) | 4 | SER A 502SER A 438PHE A 625GLU A 149 | None | 1.25A | 4xzkA-2f3oA:undetectable | 4xzkA-2f3oA:17.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h1t | HYPOTHETICAL PROTEIN (Pseudomonasaeruginosa) |
PF06475(Glycolipid_bind) | 4 | SER A 32SER A 107PHE A 109GLU A 21 | None | 1.42A | 4xzkA-2h1tA:undetectable | 4xzkA-2h1tA:22.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ixs | SDAI RESTRICTIONENDONUCLEASE (Streptomycesdiastaticus) |
PF06616(BsuBI_PstI_RE) | 4 | SER A 128TYR A 129ARG A 157PHE A 24 | NoneEPE A1329 (-4.6A)EPE A1329 ( 4.7A)None | 1.29A | 4xzkA-2ixsA:undetectable | 4xzkA-2ixsA:23.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j3z | C2 TOXIN COMPONENT I (Clostridiumbotulinum) |
PF03496(ADPrib_exo_Tox) | 4 | TYR A 257ARG A 299SER A 348GLU A 389 | GOL A1435 (-3.4A)SO4 A1438 (-3.3A)GOL A1435 ( 3.0A)GOL A1435 (-3.4A) | 0.81A | 4xzkA-2j3zA:12.4 | 4xzkA-2j3zA:20.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jeo | URIDINE-CYTIDINEKINASE 1 (Homo sapiens) |
PF00485(PRK) | 4 | SER A 37ARG A 66SER A 63GLU A 138 | None | 1.40A | 4xzkA-2jeoA:undetectable | 4xzkA-2jeoA:26.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o6r | VARIABLE LYMPHOCYTERECEPTOR B (Eptatretusburgeri) |
PF01462(LRRNT)PF11921(DUF3439)PF13855(LRR_8) | 4 | SER A 83TYR A 105ARG A 55GLU A 59 | None | 1.43A | 4xzkA-2o6rA:undetectable | 4xzkA-2o6rA:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o8r | POLYPHOSPHATE KINASE (Porphyromonasgingivalis) |
PF02503(PP_kinase)PF13089(PP_kinase_N)PF13090(PP_kinase_C) | 4 | SER A 473TYR A 592ARG A 675GLU A 594 | None | 1.30A | 4xzkA-2o8rA:undetectable | 4xzkA-2o8rA:16.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oip | CHAIN A, CRYSTALSTRUCTURE OF DHFR (Cryptosporidiumhominis) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 4 | SER A 437TYR A 438PHE A 298GLU A 294 | NoneNoneNoneCB3 A 604 ( 3.8A) | 1.41A | 4xzkA-2oipA:undetectable | 4xzkA-2oipA:17.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pka | KALLIKREIN A (Sus scrofa) |
PF00089(Trypsin) | 4 | SER A 38ARG A 70PHE A 82GLU A 64 | None | 1.33A | 4xzkA-2pkaA:undetectable | 4xzkA-2pkaA:15.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qpm | CYTOKININDEHYDROGENASE 1 (Zea mays) |
PF01565(FAD_binding_4)PF09265(Cytokin-bind) | 4 | SER A 185PHE A 374GLU A 331GLU A 288 | None | 1.13A | 4xzkA-2qpmA:undetectable | 4xzkA-2qpmA:19.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r39 | FIXG-RELATED PROTEIN (Vibrioparahaemolyticus) |
PF11614(FixG_C) | 4 | SER A 449TYR A 404PHE A 483GLU A 401 | None | 1.46A | 4xzkA-2r39A:undetectable | 4xzkA-2r39A:18.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rhq | PHENYLALANYL-TRNASYNTHETASE BETACHAIN (Staphylococcushaemolyticus) |
PF01588(tRNA_bind)PF03147(FDX-ACB)PF03483(B3_4)PF03484(B5) | 4 | SER B 281ARG B 287SER B 313GLU B 283 | None | 1.47A | 4xzkA-2rhqB:undetectable | 4xzkA-2rhqB:15.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2tdd | THYMIDYLATE SYNTHASE (Lactobacilluscasei) |
PF00303(Thymidylat_synt) | 4 | SER A 232TYR A 233PHE A 64GLU A 60 | None | 1.32A | 4xzkA-2tddA:undetectable | 4xzkA-2tddA:20.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wab | ENDOGLUCANASE E (Ruminiclostridiumthermocellum) |
PF00657(Lipase_GDSL) | 4 | SER A 98SER A 176PHE A 147GLU A 96 | BGC A1339 ( 4.0A)BGC A1339 (-4.5A)BGC A1339 ( 3.7A)BGC A1339 ( 4.0A) | 1.47A | 4xzkA-2wabA:undetectable | 4xzkA-2wabA:22.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wed | PENICILLOPEPSIN (Penicilliumjanthinellum) |
PF00026(Asp) | 4 | SER A 43TYR A 57PHE A 86GLU A 45 | None | 1.21A | 4xzkA-2wedA:undetectable | 4xzkA-2wedA:21.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wn4 | ADP-RIBOSYLTRANSFERASE ENZYMATICCOMPONENT (Clostridioidesdifficile) |
PF03496(ADPrib_exo_Tox) | 4 | TYR A 258ARG A 302SER A 345GLU A 387 | None | 0.62A | 4xzkA-2wn4A:15.0 | 4xzkA-2wn4A:20.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xy9 | ANGIOTENSIN-CONVERTING ENZYME (Homo sapiens) |
PF01401(Peptidase_M2) | 4 | SER A 147TYR A 146SER A 516GLU A 143 | None | 0.90A | 4xzkA-2xy9A:undetectable | 4xzkA-2xy9A:18.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ynm | LIGHT-INDEPENDENTPROTOCHLOROPHYLLIDEREDUCTASE SUBUNIT N (Prochlorococcusmarinus) |
PF00148(Oxidored_nitro) | 4 | SER C 133SER C 105GLU C 138GLU C 106 | None | 1.43A | 4xzkA-2ynmC:undetectable | 4xzkA-2ynmC:19.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yrr | AMINOTRANSFERASE,CLASS V (Thermusthermophilus) |
PF00266(Aminotran_5) | 4 | SER A 86ARG A 326SER A 136GLU A 134 | None | 1.30A | 4xzkA-2yrrA:undetectable | 4xzkA-2yrrA:19.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a1n | NDP-SUGAR EPIMERASE (Thermoplasmavolcanium) |
PF01370(Epimerase) | 4 | ARG A 163SER A 127GLU A 285GLU A 281 | None | 1.13A | 4xzkA-3a1nA:undetectable | 4xzkA-3a1nA:25.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3buz | IOTA TOXIN COMPONENTIA (Clostridiumperfringens) |
PF03496(ADPrib_exo_Tox) | 4 | ARG A 295SER A 338GLU A 378GLU A 380 | TAD A 500 (-3.2A)TAD A 500 (-3.2A)NoneTAD A 500 (-2.6A) | 0.87A | 4xzkA-3buzA:10.4 | 4xzkA-3buzA:19.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3buz | IOTA TOXIN COMPONENTIA (Clostridiumperfringens) |
PF03496(ADPrib_exo_Tox) | 4 | TYR A 251ARG A 295SER A 338GLU A 380 | TAD A 500 (-4.1A)TAD A 500 (-3.2A)TAD A 500 (-3.2A)TAD A 500 (-2.6A) | 0.62A | 4xzkA-3buzA:10.4 | 4xzkA-3buzA:19.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3di4 | UNCHARACTERIZEDPROTEIN DUF1989 (Ruegeriapomeroyi) |
PF09347(DUF1989) | 4 | SER A 71TYR A 221PHE A 261GLU A 259 | None | 1.40A | 4xzkA-3di4A:undetectable | 4xzkA-3di4A:21.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dwl | ACTIN-RELATEDPROTEIN 2/3 COMPLEXSUBUNIT 1ACTIN-RELATEDPROTEIN 2/3 COMPLEXSUBUNIT 4 (Schizosaccharomycespombe) |
PF00400(WD40)PF05856(ARPC4) | 4 | SER C 147SER F 43PHE F 25GLU F 45 | None | 1.40A | 4xzkA-3dwlC:undetectable | 4xzkA-3dwlC:25.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ffr | PHOSPHOSERINEAMINOTRANSFERASESERC (Cytophagahutchinsonii) |
PF00266(Aminotran_5) | 4 | SER A 94ARG A 337SER A 141GLU A 139 | None | 1.31A | 4xzkA-3ffrA:undetectable | 4xzkA-3ffrA:23.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fnb | ACYLAMINOACYLPEPTIDASE SMU_737 (Streptococcusmutans) |
PF12146(Hydrolase_4) | 4 | ARG A 97PHE A 114GLU A 118GLU A 170 | None | 1.33A | 4xzkA-3fnbA:undetectable | 4xzkA-3fnbA:19.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3git | CARBON MONOXIDEDEHYDROGENASE/ACETYL-COA SYNTHASESUBUNIT ALPHA (Moorellathermoacetica) |
PF03598(CdhC) | 4 | TYR A 413PHE A 410GLU A 455GLU A 454 | None | 1.40A | 4xzkA-3gitA:undetectable | 4xzkA-3gitA:19.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i9v | NADH-QUINONEOXIDOREDUCTASESUBUNIT 15NADH-QUINONEOXIDOREDUCTASESUBUNIT 3 (Thermusthermophilus) |
PF00384(Molybdopterin)PF01568(Molydop_binding)PF04879(Molybdop_Fe4S4)PF10588(NADH-G_4Fe-4S_3)PF11497(NADH_Oxid_Nqo15)PF13510(Fer2_4) | 4 | SER 7 58ARG 3 178GLU 7 32GLU 7 34 | NoneNone CA 3 790 ( 3.4A) CA 3 790 ( 4.3A) | 1.34A | 4xzkA-3i9v7:undetectable | 4xzkA-3i9v7:23.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jux | PROTEIN TRANSLOCASESUBUNIT SECA (Thermotogamaritima) |
PF00271(Helicase_C)PF01043(SecA_PP_bind)PF07516(SecA_SW)PF07517(SecA_DEAD) | 4 | SER A 375TYR A 374ARG A 302GLU A 768 | None | 1.29A | 4xzkA-3juxA:undetectable | 4xzkA-3juxA:14.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ke3 | PUTATIVESERINE-PYRUVATEAMINOTRANSFERASE (Psychrobacterarcticus) |
PF00266(Aminotran_5) | 4 | SER A 85ARG A 349SER A 146GLU A 144 | NoneACT A 380 (-3.1A)NoneNone | 1.20A | 4xzkA-3ke3A:undetectable | 4xzkA-3ke3A:22.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ld8 | BIFUNCTIONALARGININE DEMETHYLASEANDLYSYL-HYDROXYLASEJMJD6 (Homo sapiens) |
PF02373(JmjC) | 4 | SER A 290SER A 194PHE A 266GLU A 64 | None | 1.46A | 4xzkA-3ld8A:undetectable | 4xzkA-3ld8A:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lxq | UNCHARACTERIZEDPROTEIN VP1736 (Vibrioparahaemolyticus) |
PF00884(Sulfatase) | 4 | SER A 635TYR A 638ARG A 349SER A 348 | None | 1.20A | 4xzkA-3lxqA:undetectable | 4xzkA-3lxqA:19.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ndh | RESTRICTIONENDONUCLEASE THAI (Thermoplasmaacidophilum) |
PF15514(ThaI) | 4 | TYR A 160SER A 176GLU A 182GLU A 178 | None | 1.21A | 4xzkA-3ndhA:undetectable | 4xzkA-3ndhA:24.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o1h | PERIPLASMIC PROTEINTORT (Vibrioparahaemolyticus) |
PF00532(Peripla_BP_1) | 4 | SER B 254TYR B 252SER B 250GLU B 231 | None | 0.89A | 4xzkA-3o1hB:undetectable | 4xzkA-3o1hB:19.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o6x | GLUTAMINE SYNTHETASE (Bacteroidesfragilis) |
PF00120(Gln-synt_C)PF12437(GSIII_N) | 4 | SER A 540PHE A 534GLU A 546GLU A 542 | None | 1.44A | 4xzkA-3o6xA:undetectable | 4xzkA-3o6xA:16.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3otr | ENOLASE (Toxoplasmagondii) |
PF00113(Enolase_C)PF03952(Enolase_N) | 4 | ARG A 16SER A 385GLU A 174GLU A 217 | None | 1.42A | 4xzkA-3otrA:undetectable | 4xzkA-3otrA:19.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rc0 | N-LYSINEMETHYLTRANSFERASESETD6 (Homo sapiens) |
PF00856(SET)PF09273(Rubis-subs-bind) | 4 | SER A 104ARG A 141SER A 138GLU A 132 | None | 1.35A | 4xzkA-3rc0A:undetectable | 4xzkA-3rc0A:18.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s8d | COENZYME ATRANSFERASE (Yersinia pestis) |
PF02550(AcetylCoA_hydro)PF13336(AcetylCoA_hyd_C) | 4 | TYR A 108SER A 83PHE A 85GLU A 90 | None | 1.36A | 4xzkA-3s8dA:undetectable | 4xzkA-3s8dA:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u0j | TYPE III EFFECTORHOPU1 (Pseudomonassyringae groupgenomosp. 3) |
no annotation | 4 | ARG B 164SER B 193GLU B 233GLU B 235 | None | 0.81A | 4xzkA-3u0jB:14.0 | 4xzkA-3u0jB:23.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u4j | NAD-DEPENDENTALDEHYDEDEHYDROGENASE (Sinorhizobiummeliloti) |
PF00171(Aldedh) | 4 | ARG A 307SER A 306PHE A 426GLU A 400 | None | 1.37A | 4xzkA-3u4jA:2.2 | 4xzkA-3u4jA:17.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vbe | BETA-CYANOALNINESYNTHASE (Glycine max) |
PF00291(PALP) | 4 | SER A 151ARG A 361SER A 353GLU A 153 | None | 1.39A | 4xzkA-3vbeA:undetectable | 4xzkA-3vbeA:25.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vom | PUTATIVEPHOSPHOSERINEAMINOTRANSFERASE (Mycobacteriumtuberculosis) |
PF00266(Aminotran_5) | 4 | SER A 109ARG A 350SER A 155GLU A 153 | None | 1.37A | 4xzkA-3vomA:undetectable | 4xzkA-3vomA:21.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w3s | TYPE-2 SERINE--TRNALIGASE (Methanopyruskandleri) |
PF00587(tRNA-synt_2b) | 4 | SER A 405ARG A 485SER A 449GLU A 430 | NoneSSA A2002 ( 3.7A)SSA A2002 (-3.1A)None | 1.41A | 4xzkA-3w3sA:undetectable | 4xzkA-3w3sA:18.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wky | PROPHENOLOXIDASE B (Marsupenaeusjaponicus) |
PF00372(Hemocyanin_M)PF03722(Hemocyanin_N)PF03723(Hemocyanin_C) | 4 | SER A 617ARG A 547SER A 552GLU A 529 | None | 1.24A | 4xzkA-3wkyA:undetectable | 4xzkA-3wkyA:16.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wnb | PROTEIN TRANSLATIONELONGATION FACTOR 1A (Methanosarcinamazei) |
no annotation | 4 | SER A 327SER A 254PHE A 176GLU A 257 | None | 1.33A | 4xzkA-3wnbA:undetectable | 4xzkA-3wnbA:25.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aut | DECAPRENYL-PHOSPHORYL-BETA-D-RIBOFURANOSE-2-OXIDOREDUCTASE (Mycolicibacteriumsmegmatis) |
PF01565(FAD_binding_4)PF04030(ALO) | 4 | SER A 234TYR A 231PHE A 222GLU A 228 | None | 1.44A | 4xzkA-4autA:undetectable | 4xzkA-4autA:18.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bed | HEMOCYANIN KLH1 (Megathuracrenulata) |
PF00264(Tyrosinase)PF14830(Haemocyan_bet_s) | 4 | ARG A 775PHE A 773GLU A 599GLU A 595 | None | 1.31A | 4xzkA-4bedA:undetectable | 4xzkA-4bedA:9.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cu8 | GLYCOSIDE HYDROLASE2 (Streptococcuspneumoniae) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N)PF16355(DUF4982) | 4 | SER A 625TYR A 624ARG A 481SER A 644 | NoneEDO A2021 ( 4.4A)NoneNone | 1.43A | 4xzkA-4cu8A:undetectable | 4xzkA-4cu8A:13.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dnh | UNCHARACTERIZEDPROTEIN (Sinorhizobiummeliloti) |
PF06187(DUF993) | 4 | SER A 104ARG A 88SER A 82GLU A 81 | None | 1.42A | 4xzkA-4dnhA:undetectable | 4xzkA-4dnhA:20.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fvv | NEUROTOXIN (Clostridiumbotulinum) |
PF07951(Toxin_R_bind_C)PF07953(Toxin_R_bind_N) | 4 | SER A1242ARG A1253SER A1244GLU A1255 | NoneSO4 A1303 (-3.7A)NoneNone | 1.43A | 4xzkA-4fvvA:undetectable | 4xzkA-4fvvA:19.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fvv | NEUROTOXIN (Clostridiumbotulinum) |
PF07951(Toxin_R_bind_C)PF07953(Toxin_R_bind_N) | 4 | SER A1242TYR A1243ARG A1184GLU A1255 | None | 1.39A | 4xzkA-4fvvA:undetectable | 4xzkA-4fvvA:19.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i62 | AMINO ACID ABCTRANSPORTER,PERIPLASMIC AMINOACID-BINDINGPROTEIN, PUTATIVE (Streptococcuspneumoniae) |
PF00497(SBP_bac_3) | 4 | SER A 109SER A 158PHE A 48GLU A 197 | ARG A 301 (-2.8A)ARG A 301 (-4.8A)ARG A 301 (-3.4A)ARG A 301 (-2.7A) | 1.20A | 4xzkA-4i62A:undetectable | 4xzkA-4i62A:21.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iqq | THYMIDYLATE SYNTHASE (Caenorhabditiselegans) |
PF00303(Thymidylat_synt) | 4 | SER A 231TYR A 232PHE A 93GLU A 89 | None | 1.43A | 4xzkA-4iqqA:undetectable | 4xzkA-4iqqA:20.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4itx | CYSTATHIONINEBETA-LYASE METC (Escherichiacoli) |
PF01053(Cys_Met_Meta_PP) | 4 | TYR A 111ARG A 372SER A 158GLU A 154 | IN5 A 401 (-3.6A)IN5 A 401 (-2.9A)IN5 A 401 ( 4.0A)IN5 A 401 (-3.7A) | 1.28A | 4xzkA-4itxA:undetectable | 4xzkA-4itxA:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nhy | 2-OXOGLUTARATE ANDIRON-DEPENDENTOXYGENASEDOMAIN-CONTAININGPROTEIN 1 (Homo sapiens) |
PF10637(Ofd1_CTDD)PF13661(2OG-FeII_Oxy_4) | 4 | SER A 142ARG A 230SER A 232PHE A 98 | NonePD2 A 603 (-2.6A)PD2 A 603 (-3.1A)None | 1.38A | 4xzkA-4nhyA:undetectable | 4xzkA-4nhyA:20.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nre | ARACHIDONATE15-LIPOXYGENASE B (Homo sapiens) |
PF00305(Lipoxygenase)PF01477(PLAT) | 4 | SER A 675TYR A 408GLU A 613GLU A 671 | GOL A 718 ( 4.6A)SO4 A 710 (-4.8A)GOL A 718 (-3.3A)GOL A 718 ( 4.8A) | 1.48A | 4xzkA-4nreA:undetectable | 4xzkA-4nreA:18.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oua | LATENT FORM OF PPO4TYROSINASE (Agaricusbisporus) |
PF00264(Tyrosinase) | 4 | SER B 311TYR B 75ARG B 466GLU B 307 | None | 1.42A | 4xzkA-4ouaB:undetectable | 4xzkA-4ouaB:18.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pn0 | MRNA-CAPPING ENZYMESUBUNIT BETA (Schizosaccharomycespombe) |
PF02940(mRNA_triPase) | 4 | ARG A 203SER A 205GLU A 260GLU A 80 | None | 1.32A | 4xzkA-4pn0A:undetectable | 4xzkA-4pn0A:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q8k | ALGINASE (Pseudoalteromonassp. SM0524) |
PF08787(Alginate_lyase2) | 4 | TYR A 270SER A 272PHE A 279GLU A 276 | SO4 A 502 (-4.8A)NoneNoneSO4 A 502 ( 4.7A) | 1.39A | 4xzkA-4q8kA:undetectable | 4xzkA-4q8kA:19.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q8l | ALGINASE (Pseudoalteromonassp. SM0524) |
PF08787(Alginate_lyase2) | 4 | TYR A 103SER A 105PHE A 112GLU A 109 | None | 1.40A | 4xzkA-4q8lA:undetectable | 4xzkA-4q8lA:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u48 | PUTATIVE INNERMEMBRANE LIPOPROTEIN (Salmonellaenterica) |
PF00207(A2M)PF01835(A2M_N)PF07703(A2M_N_2)PF10569(Thiol-ester_cl)PF11974(MG1) | 4 | SER A1415ARG A1363SER A1375GLU A1418 | None | 1.30A | 4xzkA-4u48A:undetectable | 4xzkA-4u48A:10.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xgk | UDP-GALACTOPYRANOSEMUTASE (Corynebacteriumdiphtheriae) |
PF03275(GLF)PF13450(NAD_binding_8) | 4 | TYR A 325ARG A 316PHE A 261GLU A 313 | FDA A 403 (-4.2A)NoneNoneNone | 1.33A | 4xzkA-4xgkA:undetectable | 4xzkA-4xgkA:20.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ypj | BETA GALACTOSIDASE (Bacilluscirculans) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N)PF16355(DUF4982) | 4 | SER A 512TYR A 511ARG A 376SER A 531 | None | 1.45A | 4xzkA-4ypjA:undetectable | 4xzkA-4ypjA:14.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ys4 | MEROZOITE SURFACEPROTEIN P41 (Plasmodiumfalciparum) |
PF07422(s48_45) | 4 | TYR A 328SER A 325PHE A 286GLU A 288 | NoneNoneGOL A 406 ( 3.7A)None | 1.28A | 4xzkA-4ys4A:undetectable | 4xzkA-4ys4A:20.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yzw | AGAP004976-PA (Anophelesgambiae) |
PF00372(Hemocyanin_M)PF03722(Hemocyanin_N)PF03723(Hemocyanin_C) | 4 | TYR A 640ARG A 561SER A 566GLU A 544 | None | 1.33A | 4xzkA-4yzwA:undetectable | 4xzkA-4yzwA:16.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ziu | UNCHARACTERIZEDLIPOPROTEIN YFHM (Escherichiacoli) |
PF07678(A2M_comp) | 4 | SER A1424ARG A1371SER A1384GLU A1427 | None | 1.27A | 4xzkA-4ziuA:undetectable | 4xzkA-4ziuA:18.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a08 | PROBABLEMANNOSYLTRANSFERASEKTR4 (Saccharomycescerevisiae) |
PF01793(Glyco_transf_15) | 4 | SER A 457SER A 399GLU A 459GLU A 460 | None | 1.17A | 4xzkA-5a08A:undetectable | 4xzkA-5a08A:20.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a42 | UNCHARACTERIZEDLIPOPROTEIN YFHM (Escherichiacoli) |
PF00207(A2M)PF01835(A2M_N)PF07703(A2M_N_2)PF11974(MG1) | 4 | SER A1424ARG A1371SER A1384GLU A1427 | None | 1.33A | 4xzkA-5a42A:undetectable | 4xzkA-5a42A:9.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a6f | GATING RING OFPOTASSIUM CHANNELSUBFAMILY T MEMBER 1 (Gallus gallus) |
PF03493(BK_channel_a) | 4 | SER C 536TYR C 532PHE C 933GLU C 520 | None | 1.26A | 4xzkA-5a6fC:undetectable | 4xzkA-5a6fC:17.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dm3 | L-GLUTAMINESYNTHETASE (Chromohalobactersalexigens) |
PF00120(Gln-synt_C) | 4 | ARG A 315SER A 260GLU A 206GLU A 145 | None | 1.27A | 4xzkA-5dm3A:undetectable | 4xzkA-5dm3A:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5edu | MALTOSE-BINDINGPERIPLASMIC PROTEIN,HISTONE DEACETYLASE6 CHIMERA (Escherichiacoli;Homo sapiens) |
no annotation | 4 | SER B 479TYR B 449ARG B 174SER B 445 | NoneNoneMAL B2505 (-3.5A)None | 1.20A | 4xzkA-5eduB:undetectable | 4xzkA-5eduB:17.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gr1 | 1,4-ALPHA-GLUCANBRANCHING ENZYMEGLGB (Cyanothece sp.ATCC 51142) |
PF00128(Alpha-amylase)PF02806(Alpha-amylase_C)PF02922(CBM_48) | 4 | SER A 339TYR A 212SER A 336GLU A 320 | None | 1.38A | 4xzkA-5gr1A:undetectable | 4xzkA-5gr1A:14.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gut | DNA(CYTOSINE-5)-METHYLTRANSFERASE 1 (Mus musculus) |
PF00145(DNA_methylase)PF01426(BAH) | 4 | SER A1094TYR A1092SER A1048GLU A1050 | None | 1.09A | 4xzkA-5gutA:undetectable | 4xzkA-5gutA:14.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h04 | BINARY ENTEROTOXINOF CLOSTRIDIUMPERFRINGENSCOMPONENT A (Clostridiumperfringens) |
PF03496(ADPrib_exo_Tox) | 4 | TYR A 252ARG A 297SER A 340GLU A 382 | NAI A 501 (-3.4A)NAI A 501 (-2.8A)NAI A 501 (-2.6A)NAI A 501 (-3.1A) | 1.16A | 4xzkA-5h04A:15.3 | 4xzkA-5h04A:20.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h04 | BINARY ENTEROTOXINOF CLOSTRIDIUMPERFRINGENSCOMPONENT A (Clostridiumperfringens) |
PF03496(ADPrib_exo_Tox) | 4 | TYR A 252SER A 340PHE A 351GLU A 382 | NAI A 501 (-3.4A)NAI A 501 (-2.6A)NAI A 501 (-4.0A)NAI A 501 (-3.1A) | 1.32A | 4xzkA-5h04A:15.3 | 4xzkA-5h04A:20.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hw3 | BETA-LACTAMASE (Burkholderiavietnamiensis) |
PF13354(Beta-lactamase2) | 4 | SER A 70ARG A 165SER A 170GLU A 167 | SO4 A 301 (-2.7A)NoneNoneNone | 1.32A | 4xzkA-5hw3A:undetectable | 4xzkA-5hw3A:22.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ig3 | CALCIUM/CALMODULIN-DEPENDENT PROTEINKINASE TYPE IISUBUNIT ALPHA (Homo sapiens) |
PF08332(CaMKII_AD) | 4 | TYR A 369ARG A 433PHE A 467GLU A 381 | None | 1.44A | 4xzkA-5ig3A:undetectable | 4xzkA-5ig3A:25.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kwl | VP3 (Enterovirus C) |
PF00073(Rhv) | 4 | SER 3 86SER 3 91PHE 3 184GLU 3 186 | None | 1.38A | 4xzkA-5kwl3:undetectable | 4xzkA-5kwl3:20.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mkk | MULTIDRUG RESISTANCEABC TRANSPORTERATP-BINDING ANDPERMEASE PROTEIN (Thermusthermophilus) |
PF00005(ABC_tran)PF00664(ABC_membrane) | 4 | SER B 425ARG B 487PHE B 422GLU A 218 | None | 1.20A | 4xzkA-5mkkB:undetectable | 4xzkA-5mkkB:18.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oqm | GENERALTRANSCRIPTION ANDDNA REPAIR FACTORIIH HELICASE SUBUNITXPB (Saccharomycescerevisiae) |
no annotation | 4 | SER 7 675ARG 7 681SER 7 679GLU 7 683 | None | 1.39A | 4xzkA-5oqm7:undetectable | 4xzkA-5oqm7:13.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t0l | BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Toxoplasmagondii) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 4 | SER A 524TYR A 525PHE A 385GLU A 381 | NoneNoneNoneCB3 A 703 ( 4.1A) | 1.27A | 4xzkA-5t0lA:undetectable | 4xzkA-5t0lA:19.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tj3 | ALKALINE PHOSPHATASEPAFA (Elizabethkingiameningoseptica) |
PF01663(Phosphodiest) | 4 | SER A 315PHE A 249GLU A 317GLU A 238 | NoneNone ZN A 603 (-2.3A) ZN A 603 (-2.7A) | 1.32A | 4xzkA-5tj3A:undetectable | 4xzkA-5tj3A:18.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wab | PUTATIVEBETA-GLUCOSIDASE (Bifidobacteriumadolescentis) |
no annotation | 4 | SER A 254TYR A 255SER A 22GLU A 250 | None | 1.35A | 4xzkA-5wabA:undetectable | 4xzkA-5wabA:18.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y3r | DNA-DEPENDENTPROTEIN KINASECATALYTIC SUBUNITX-RAY REPAIRCROSS-COMPLEMENTINGPROTEIN 6 (Homo sapiens) |
PF00454(PI3_PI4_kinase)PF02259(FAT)PF02260(FATC)PF02735(Ku)PF03730(Ku_C)PF03731(Ku_N)PF08163(NUC194) | 4 | ARG C 213SER C 210GLU A 333GLU A 332 | None | 1.22A | 4xzkA-5y3rC:undetectable | 4xzkA-5y3rC:4.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zq6 | SIDE (Legionellapneumophila) |
no annotation | 4 | SER A 815PHE A 827GLU A 855GLU A 857 | None | 0.63A | 4xzkA-5zq6A:9.8 | 4xzkA-5zq6A:18.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6d6q | EXOSOME RNA HELICASEMTR4 (Homo sapiens) |
no annotation | 4 | SER M 588TYR M 590SER M 561GLU M 267 | None | 1.25A | 4xzkA-6d6qM:undetectable | 4xzkA-6d6qM:17.96 |