SIMILAR PATTERNS OF AMINO ACIDS FOR 4XV2_B_P06B801_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgm ADENOSINE KINASE

(Toxoplasma
gondii) 		PF00294
(PfkB) 		4 GLY A 280
VAL A 302
PHE A 324
ILE A 338
 None
 1.15A 4xv2B-1dgmA:
undetectable		 4xv2B-1dgmA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g61 TRANSLATION
INITIATION FACTOR 6

(Methanocaldococcus
jannaschii) 		PF01912
(eIF-6) 		4 GLY A2069
VAL A2064
PHE A2127
ILE A2100
 None
 1.03A 4xv2B-1g61A:
undetectable		 4xv2B-1g61A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2h HYPOTHETICAL PROTEIN
TM1643

(Thermotoga
maritima) 		PF01958
(DUF108)
PF03447
(NAD_binding_3) 		4 GLY A 174
VAL A 178
PHE A 206
ILE A 197
 None
 1.08A 4xv2B-1h2hA:
undetectable		 4xv2B-1h2hA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h71 SERRALYSIN

(Pseudomonas sp.
'TAC II 18') 		PF00413
(Peptidase_M10)
PF08548
(Peptidase_M10_C) 		4 GLY P 376
VAL P 374
PHE P  14
ILE P 338
 None
 0.92A 4xv2B-1h71P:
0.0		 4xv2B-1h71P:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h79 ANAEROBIC
RIBONUCLEOTIDE-TRIPH
OSPHATE REDUCTASE
LARGE CHAIN

(Escherichia
virus T4) 		PF13597
(NRDD) 		4 GLY A 106
VAL A 171
PHE A 199
ILE A 214
 None
 1.07A 4xv2B-1h79A:
0.1		 4xv2B-1h79A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1f GLUTAMATE
DEHYDROGENASE 1

(Homo sapiens) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 GLY A 260
VAL A 253
PHE A 298
ILE A 305
 None
 1.17A 4xv2B-1l1fA:
0.0		 4xv2B-1l1fA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mg5 ALCOHOL
DEHYDROGENASE

(Drosophila
melanogaster) 		PF00106
(adh_short) 		4 GLY A 142
VAL A 160
PHE A 222
ILE A 137
 None
None
None
NAI  A 850 (-4.1A)
 1.08A 4xv2B-1mg5A:
0.6		 4xv2B-1mg5A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n76 LACTOFERRIN

(Homo sapiens) 		PF00405
(Transferrin) 		4 GLY A 124
VAL A 127
PHE A 325
ILE A 328
 CO3  A 695 (-4.0A)
None
None
None
 1.14A 4xv2B-1n76A:
0.0		 4xv2B-1n76A:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oq1 PROTEIN YESU

(Bacillus
subtilis) 		PF09224
(DUF1961) 		4 GLY A 167
VAL A 169
PHE A  56
ILE A  60
 None
 1.15A 4xv2B-1oq1A:
undetectable		 4xv2B-1oq1A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r8w GLYCEROL DEHYDRATASE

(Clostridium
butyricum) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 GLY A 254
VAL A 219
PHE A 267
ILE A 270
 None
 1.17A 4xv2B-1r8wA:
undetectable		 4xv2B-1r8wA:
16.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ru4 PECTATE LYASE

(Dickeya
chrysanthemi) 		PF13229
(Beta_helix) 		4 GLY A 281
VAL A 307
PHE A 236
ILE A 247
 None
 1.10A 4xv2B-1ru4A:
undetectable		 4xv2B-1ru4A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s4f RNA-DEPENDENT RNA
POLYMERASE

(Pestivirus A) 		PF00998
(RdRP_3) 		4 GLY A 459
VAL A 487
PHE A 491
ILE A 494
 None
 1.05A 4xv2B-1s4fA:
undetectable		 4xv2B-1s4fA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uek 4-(CYTIDINE
5'-DIPHOSPHO)-2C-MET
HYL-D-ERYTHRITOL
KINASE

(Thermus
thermophilus) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 GLY A  75
VAL A  44
PHE A  50
ILE A  79
 None
 1.11A 4xv2B-1uekA:
undetectable		 4xv2B-1uekA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbl PECTATE LYASE 47

(Bacillus sp.
TS-47) 		PF00544
(Pec_lyase_C) 		4 GLY A  65
VAL A 139
PHE A  33
ILE A  61
 None
 1.12A 4xv2B-1vblA:
undetectable		 4xv2B-1vblA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vqv THIAMINE
MONOPHOSPHATE KINASE

(Aquifex
aeolicus) 		PF00586
(AIRS) 		4 GLY A 134
VAL A  72
PHE A 110
ILE A 192
 None
 0.94A 4xv2B-1vqvA:
undetectable		 4xv2B-1vqvA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wvg CDP-GLUCOSE
4,6-DEHYDRATASE

(Salmonella
enterica) 		PF16363
(GDP_Man_Dehyd) 		4 GLY A 124
VAL A 188
PHE A  87
ILE A  85
 None
 1.14A 4xv2B-1wvgA:
undetectable		 4xv2B-1wvgA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x5n HARMONIN

(Homo sapiens) 		PF00595
(PDZ) 		4 GLY A 100
VAL A  96
PHE A  73
ILE A  65
 None
 1.03A 4xv2B-1x5nA:
undetectable		 4xv2B-1x5nA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ywf PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
PTPB

(Mycobacterium
tuberculosis) 		PF13350
(Y_phosphatase3) 		4 GLY A  67
VAL A  75
PHE A  28
ILE A  49
 None
 0.88A 4xv2B-1ywfA:
undetectable		 4xv2B-1ywfA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zov MONOMERIC SARCOSINE
OXIDASE

(Bacillus sp.
NS-129) 		PF01266
(DAO) 		4 GLY A 312
VAL A 224
PHE A 297
ILE A 266
 None
 1.17A 4xv2B-1zovA:
undetectable		 4xv2B-1zovA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ae6 ACETYLTRANSFERASE,
GNAT FAMILY

(Enterococcus
faecalis) 		PF00583
(Acetyltransf_1) 		4 GLY A  94
VAL A  86
PHE A  53
ILE A  65
 None
 1.17A 4xv2B-2ae6A:
undetectable		 4xv2B-2ae6A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bfw GLGA GLYCOGEN
SYNTHASE

(Pyrococcus
abyssi) 		PF00534
(Glycos_transf_1) 		4 GLY A 256
VAL A 265
PHE A 252
ILE A 333
 SO4  A1417 ( 2.6A)
None
None
None
 1.15A 4xv2B-2bfwA:
undetectable		 4xv2B-2bfwA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eo0 HYPOTHETICAL PROTEIN
ST1444

(Sulfurisphaera
tokodaii) 		PF01870
(Hjc) 		4 GLY A  26
VAL A  29
PHE A  90
ILE A  55
 None
 1.12A 4xv2B-2eo0A:
undetectable		 4xv2B-2eo0A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hu9 MERCURIC TRANSPORT
PROTEIN PERIPLASMIC
COMPONENT

(Archaeoglobus
fulgidus) 		no annotation 4 GLY A 104
VAL A  80
PHE A  92
ILE A 100
 FES  A 131 (-3.5A)
None
None
None
 1.16A 4xv2B-2hu9A:
undetectable		 4xv2B-2hu9A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Bacillus
anthracis) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		4 GLY A  59
VAL A  51
PHE A 343
ILE A  68
 None
 0.91A 4xv2B-2ifyA:
undetectable		 4xv2B-2ifyA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ly3 TRANSLOCATION AND
ASSEMBLY MODULE TAMA

(Escherichia
coli) 		PF17243
(POTRA_TamA_1) 		4 GLY 1  68
VAL 1  39
PHE 1  57
ILE 1  46
 None
 1.16A 4xv2B-2ly31:
undetectable		 4xv2B-2ly31:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjt BETA-KETOACYL-ACP
SYNTHASE II

(Streptococcus
pneumoniae) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 GLY A 228
VAL A 230
PHE A  46
ILE A 200
 None
 1.16A 4xv2B-2rjtA:
undetectable		 4xv2B-2rjtA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ucz UBIQUITIN
CONJUGATING ENZYME

(Saccharomyces
cerevisiae) 		PF00179
(UQ_con) 		4 GLY A  27
VAL A  25
PHE A  54
ILE A  41
 None
 1.09A 4xv2B-2uczA:
undetectable		 4xv2B-2uczA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vqa SLL1358 PROTEIN

(Synechocystis
sp. PCC 6803) 		PF00190
(Cupin_1) 		4 GLY A 321
VAL A 294
PHE A 388
ILE A 272
 None
 0.90A 4xv2B-2vqaA:
undetectable		 4xv2B-2vqaA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vug PAB1020

(Pyrococcus
abyssi) 		PF09414
(RNA_ligase) 		4 GLY A  80
VAL A 240
PHE A 203
ILE A 229
 None
 0.89A 4xv2B-2vugA:
undetectable		 4xv2B-2vugA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
CYTOCHROME C OXIDASE
SUBUNIT 2

(Thermus
thermophilus) 		PF00034
(Cytochrom_C)
PF00115
(COX1)
PF00116
(COX2)
PF00510
(COX3)
PF02790
(COX2_TM) 		4 GLY B 195
VAL B  22
PHE A 376
ILE B  24
 None
 1.16A 4xv2B-2yevB:
undetectable		 4xv2B-2yevB:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zqp PREPROTEIN
TRANSLOCASE SECY
SUBUNIT

(Thermus
thermophilus) 		PF00344
(SecY) 		4 GLY Y  38
VAL Y 157
PHE Y  73
ILE Y  72
 None
 0.78A 4xv2B-2zqpY:
undetectable		 4xv2B-2zqpY:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a8p T-LYMPHOMA INVASION
AND
METASTASIS-INDUCING
PROTEIN 2

(Mus musculus) 		PF00169
(PH) 		4 GLY A 593
VAL A 595
PHE A 690
ILE A 572
 None
 1.17A 4xv2B-3a8pA:
undetectable		 4xv2B-3a8pA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3act CELLOBIOSE
PHOSPHORYLASE

(Cellulomonas
gilvus) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 GLY A 171
VAL A 173
PHE A 217
ILE A 246
 None
 1.04A 4xv2B-3actA:
undetectable		 4xv2B-3actA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3act CELLOBIOSE
PHOSPHORYLASE

(Cellulomonas
gilvus) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 GLY A 242
VAL A 173
PHE A 217
ILE A 246
 None
 1.08A 4xv2B-3actA:
undetectable		 4xv2B-3actA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c9r THIAMINE
MONOPHOSPHATE KINASE

(Aquifex
aeolicus) 		PF00586
(AIRS) 		4 GLY A 134
VAL A  72
PHE A 110
ILE A 192
 None
 0.95A 4xv2B-3c9rA:
undetectable		 4xv2B-3c9rA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cps GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Cryptosporidium
parvum) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 GLY A  78
VAL A  90
PHE A  70
ILE A  83
 None
 1.01A 4xv2B-3cpsA:
undetectable		 4xv2B-3cpsA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h39 TRNA NUCLEOTIDYL
TRANSFERASE-RELATED
PROTEIN

(Thermotoga
maritima) 		PF01743
(PolyA_pol)
PF12627
(PolyA_pol_RNAbd) 		4 GLY A  41
VAL A  39
PHE A   4
ILE A 149
 ATP  A 501 (-3.3A)
None
None
None
 1.15A 4xv2B-3h39A:
undetectable		 4xv2B-3h39A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hc7 GENE 12 PROTEIN

(Mycobacterium
virus D29) 		PF01083
(Cutinase) 		4 GLY A  89
VAL A  57
PHE A 106
ILE A  64
 None
 1.11A 4xv2B-3hc7A:
undetectable		 4xv2B-3hc7A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hgo 12-OXOPHYTODIENOATE
REDUCTASE 3

(Solanum
lycopersicum) 		PF00724
(Oxidored_FMN) 		4 GLY A 327
VAL A 331
PHE A  59
ILE A 317
 None
 1.17A 4xv2B-3hgoA:
undetectable		 4xv2B-3hgoA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l01 GLGA GLYCOGEN
SYNTHASE

(Pyrococcus
abyssi) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		4 GLY A 256
VAL A 265
PHE A 252
ILE A 333
 None
 1.14A 4xv2B-3l01A:
undetectable		 4xv2B-3l01A:
22.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 GLY A 358
VAL A 363
PHE A 408
ILE A 419
 None
SM5  A   1 (-4.0A)
None
SM5  A   1 ( 4.3A)
 0.44A 4xv2B-3omvA:
35.4		 4xv2B-3omvA:
72.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qde CELLOBIOSE
PHOSPHORYLASE

(Ruminiclostridium
thermocellum) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 GLY A 171
VAL A 173
PHE A 212
ILE A 241
 None
 1.11A 4xv2B-3qdeA:
undetectable		 4xv2B-3qdeA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qde CELLOBIOSE
PHOSPHORYLASE

(Ruminiclostridium
thermocellum) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 GLY A 237
VAL A 173
PHE A 212
ILE A 241
 None
 1.14A 4xv2B-3qdeA:
undetectable		 4xv2B-3qdeA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rru TOM1L1 PROTEIN

(Homo sapiens) 		PF00790
(VHS) 		4 GLY A 129
VAL A 134
PHE A  96
ILE A  91
 None
 1.05A 4xv2B-3rruA:
undetectable		 4xv2B-3rruA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4d LACTOSE
PHOSPHORYLASE

(Cellulomonas
uda) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 GLY A 171
VAL A 173
PHE A 217
ILE A 246
 None
 1.14A 4xv2B-3s4dA:
undetectable		 4xv2B-3s4dA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 GLY A 426
VAL A 431
PHE A 475
ILE A 487
 PP2  A   1 ( 4.8A)
PP2  A   1 (-4.5A)
None
PP2  A   1 (-3.6A)
 0.47A 4xv2B-3sxsA:
28.2		 4xv2B-3sxsA:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vb0 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Sphingomonas
wittichii) 		PF00903
(Glyoxalase) 		4 GLY A  30
VAL A  33
PHE A  11
ILE A  52
 None
 1.17A 4xv2B-3vb0A:
undetectable		 4xv2B-3vb0A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vi1 ALKALINE
METALLOPROTEINASE

(Pseudomonas
aeruginosa) 		PF08548
(Peptidase_M10_C)
PF13583
(Reprolysin_4) 		4 GLY A 379
VAL A 377
PHE A  12
ILE A 341
 None
 0.82A 4xv2B-3vi1A:
undetectable		 4xv2B-3vi1A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vta CUCUMISIN

(Cucumis melo) 		PF00082
(Peptidase_S8) 		4 GLY A 674
VAL A 708
PHE A 637
ILE A 725
 None
 1.07A 4xv2B-3vtaA:
undetectable		 4xv2B-3vtaA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3s 6-PHOSPHOFRUCTOKINAS
E

(Bacillus
subtilis) 		PF00365
(PFK) 		4 GLY A 268
VAL A 284
PHE A 135
ILE A 286
 None
 0.97A 4xv2B-4a3sA:
undetectable		 4xv2B-4a3sA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw7 GH86A
BETA-PORPHYRANASE

(Bacteroides
plebeius) 		no annotation 4 GLY A 166
VAL A 164
PHE A 176
ILE A 120
 None
 0.91A 4xv2B-4aw7A:
2.2		 4xv2B-4aw7A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dqd EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Rhodopseudomonas
palustris) 		PF13458
(Peripla_BP_6) 		4 GLY A 256
VAL A 225
PHE A 236
ILE A 240
 None
 1.06A 4xv2B-4dqdA:
undetectable		 4xv2B-4dqdA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fn5 ELONGATION FACTOR G
1

(Pseudomonas
aeruginosa) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		4 GLY A 611
VAL A 499
PHE A 539
ILE A 520
 None
 1.13A 4xv2B-4fn5A:
undetectable		 4xv2B-4fn5A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g38 SULFITE REDUCTASE
[NADPH] HEMOPROTEIN
BETA-COMPONENT

(Escherichia
coli) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 GLY A 351
VAL A 349
PHE A 390
ILE A 400
 None
 1.14A 4xv2B-4g38A:
undetectable		 4xv2B-4g38A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl9 SUPPRESSOR OF
CYTOKINE SIGNALING
3,SUPPRESSOR OF
CYTOKINE SIGNALING
3,SUPPRESSOR OF
CYTOKINE SIGNALING
3,SUPPRESSOR OF
CYTOKINE SIGNALING 3

(Mus musculus) 		PF00017
(SH2) 		4 GLY E  53
VAL E  51
PHE E  46
ILE E  70
 None
 1.09A 4xv2B-4gl9E:
undetectable		 4xv2B-4gl9E:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h09 HYPOTHETICAL LEUCINE
RICH REPEAT PROTEIN

(Eubacterium
ventriosum) 		PF13306
(LRR_5) 		4 GLY A 243
VAL A 239
PHE A 301
ILE A 285
 None
None
None
EDO  A 510 (-4.6A)
 1.10A 4xv2B-4h09A:
undetectable		 4xv2B-4h09A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4he4 YELLOW FLUORESCENT
PROTEIN

(Phialidium sp.
SL-2003) 		PF01353
(GFP) 		4 GLY A  40
VAL A  42
PHE A 112
ILE A  12
 None
 0.86A 4xv2B-4he4A:
undetectable		 4xv2B-4he4A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hva CASPASE-6

(Homo sapiens) 		PF00656
(Peptidase_C14) 		4 GLY A 215
VAL A 212
PHE A 118
ILE A 160
 None
 1.08A 4xv2B-4hvaA:
undetectable		 4xv2B-4hvaA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwg UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Rickettsia
bellii) 		PF02350
(Epimerase_2) 		4 GLY A 167
VAL A 354
PHE A 113
ILE A 361
 None
 0.81A 4xv2B-4hwgA:
undetectable		 4xv2B-4hwgA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyd PUTATIVE
UNCHARACTERIZED
PROTEIN

(Methanoculleus
marisnigri) 		PF06550
(SPP) 		4 GLY A 250
VAL A 228
PHE A  18
ILE A  21
 None
 0.91A 4xv2B-4hydA:
undetectable		 4xv2B-4hydA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i4i 6-PHOSPHOFRUCTOKINAS
E

(Geobacillus
stearothermophilus) 		PF00365
(PFK) 		4 GLY A 268
VAL A 284
PHE A 135
ILE A 286
 None
 0.91A 4xv2B-4i4iA:
undetectable		 4xv2B-4i4iA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jnd CA(2+)/CALMODULIN-DE
PENDENT PROTEIN
KINASE PHOSPHATASE

(Caenorhabditis
elegans) 		PF00481
(PP2C) 		4 GLY A 422
VAL A 420
PHE A 376
ILE A 404
 None
 0.98A 4xv2B-4jndA:
undetectable		 4xv2B-4jndA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4obu PYRIDOXAL-DEPENDENT
DECARBOXYLASE DOMAIN
PROTEIN

([Ruminococcus]
gnavus) 		no annotation 4 GLY E 159
VAL E 317
PHE E 271
ILE E 273
 PLP  E 501 (-3.5A)
None
None
None
 1.13A 4xv2B-4obuE:
1.8		 4xv2B-4obuE:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1i AMINOBENZOYL-GLUTAMA
TE TRANSPORTER

(Neisseria
gonorrhoeae) 		PF03806
(ABG_transport) 		4 GLY A 198
VAL A  99
PHE A 188
ILE A 319
 None
 1.03A 4xv2B-4r1iA:
undetectable		 4xv2B-4r1iA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ra7 PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE

(Atopobium
parvulum) 		PF00905
(Transpeptidase) 		4 GLY A 762
VAL A 827
PHE A 908
ILE A 821
 None
 1.17A 4xv2B-4ra7A:
undetectable		 4xv2B-4ra7A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1

(Homo sapiens;
synthetic
construct) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 GLY A1984
VAL A2169
PHE A2421
ILE A2424
 ATP  A4403 (-2.9A)
None
None
None
 1.12A 4xv2B-4rh7A:
undetectable		 4xv2B-4rh7A:
6.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rld ASPARTIC PROTEASE
BLA G 2

(Blattella
germanica) 		PF00026
(Asp) 		4 GLY A  16
VAL A   4
PHE A 313
ILE A 153
 None
 1.00A 4xv2B-4rldA:
undetectable		 4xv2B-4rldA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tsh SURFACE PROTEIN
ADHESIN

(Streptococcus
mutans) 		PF16364
(Antigen_C) 		4 GLY B1398
VAL B1430
PHE B1385
ILE B1439
 None
 1.15A 4xv2B-4tshB:
undetectable		 4xv2B-4tshB:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u7d ATP-DEPENDENT DNA
HELICASE Q1

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF16124
(RecQ_Zn_bind) 		4 GLY A 252
VAL A 109
PHE A  92
ILE A 100
 None
 1.03A 4xv2B-4u7dA:
undetectable		 4xv2B-4u7dA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4us4 TRANSPORTER

(Bacillus
halodurans) 		PF00209
(SNF) 		4 GLY A  94
VAL A 331
PHE A 230
ILE A 104
 None
None
TRP  A 601 (-4.4A)
None
 1.10A 4xv2B-4us4A:
0.9		 4xv2B-4us4A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ywo MERCURIC REDUCTASE

(Metallosphaera
sedula) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 GLY A 273
VAL A 276
PHE A 126
ILE A 287
 None
 1.15A 4xv2B-4ywoA:
undetectable		 4xv2B-4ywoA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yxf MUPS

(Pseudomonas
fluorescens) 		PF13561
(adh_short_C2) 		4 GLY A 146
VAL A 148
PHE A  84
ILE A  25
 None
 1.03A 4xv2B-4yxfA:
undetectable		 4xv2B-4yxfA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zj8 HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE

(Homo sapiens;
Pyrococcus
abyssi) 		PF00001
(7tm_1)
PF00534
(Glycos_transf_1) 		4 GLY A1039
VAL A1048
PHE A1035
ILE A1116
 None
 1.11A 4xv2B-4zj8A:
0.5		 4xv2B-4zj8A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoh PUTATIVE
OXIDOREDUCTASE
MOLYBDOPTERIN-BINDIN
G SUBUNIT

(Sulfurisphaera
tokodaii) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 GLY A 137
VAL A 140
PHE A 262
ILE A 275
 None
 1.16A 4xv2B-4zohA:
undetectable		 4xv2B-4zohA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aoh CARF

(Serratia sp.
ATCC 39006) 		PF03781
(FGE-sulfatase) 		4 GLY A  65
VAL A  87
PHE A 230
ILE A 257
 None
 1.13A 4xv2B-5aohA:
0.7		 4xv2B-5aohA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b23 UNCHARACTERIZED
PROTEIN SORTASE B

(Clostridium
perfringens) 		PF04203
(Sortase) 		4 GLY A  96
VAL A 119
PHE A  91
ILE A 117
 None
 1.13A 4xv2B-5b23A:
undetectable		 4xv2B-5b23A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bnd ABC TRANSPORTER,
ATP-BINDING PROTEIN

(Staphylococcus
epidermidis) 		no annotation 4 GLY A 460
VAL A 462
PHE A 385
ILE A 492
 None
 1.12A 4xv2B-5bndA:
undetectable		 4xv2B-5bndA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dl7 PORIN

(Acinetobacter
baumannii) 		PF03573
(OprD) 		4 GLY A 268
VAL A 304
PHE A 233
ILE A 252
 None
 1.14A 4xv2B-5dl7A:
undetectable		 4xv2B-5dl7A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dqn CYTOCHROME P450
CYP125

(Mycolicibacterium
smegmatis) 		PF00067
(p450) 		4 GLY A  46
VAL A  92
PHE A 299
ILE A  80
 None
None
HEM  A 501 (-4.2A)
None
 1.08A 4xv2B-5dqnA:
undetectable		 4xv2B-5dqnA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dxx ARTEMISINIC ALDEHYDE
DELTA(11(13))
REDUCTASE

(Artemisia annua) 		PF00724
(Oxidored_FMN) 		4 GLY A 324
VAL A 328
PHE A  54
ILE A 314
 None
 1.14A 4xv2B-5dxxA:
undetectable		 4xv2B-5dxxA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqi SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 1

(Homo sapiens) 		PF00083
(Sugar_tr) 		4 GLY A  27
VAL A  32
PHE A 194
ILE A 192
 None
 1.11A 4xv2B-5eqiA:
undetectable		 4xv2B-5eqiA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g3z ADENYLATE KINSE

(synthetic
construct) 		PF00406
(ADK)
PF05191
(ADK_lid) 		4 GLY A  85
VAL A   4
PHE A 205
ILE A  20
 AP5  A1217 (-4.3A)
None
None
None
 1.17A 4xv2B-5g3zA:
undetectable		 4xv2B-5g3zA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5im5 DESIGNED
KETO-HYDROXYGLUTARAT
E-ALDOLASE/KETO-DEOX
Y-PHOSPHOGLUCONATE
ALDOLASE

(Vibrionales
bacterium
SWAT-3) 		no annotation 4 GLY P 110
VAL P 108
PHE P  44
ILE P  70
 None
 1.15A 4xv2B-5im5P:
undetectable		 4xv2B-5im5P:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ir6 BD-TYPE QUINOL
OXIDASE SUBUNIT I
BD-TYPE QUINOL
OXIDASE SUBUNIT II

(Geobacillus
stearothermophilus) 		PF01654
(Cyt_bd_oxida_I)
PF02322
(Cyt_bd_oxida_II) 		4 GLY A  76
VAL B  68
PHE A 152
ILE A  94
 HEB  A 502 (-3.4A)
None
None
None
 1.03A 4xv2B-5ir6A:
3.0		 4xv2B-5ir6A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Caenorhabditis
elegans) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		4 GLY A  84
VAL A  76
PHE A 367
ILE A  93
 None
 0.87A 4xv2B-5kgnA:
undetectable		 4xv2B-5kgnA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mj7 UNCHARACTERIZED
PROTEIN

(Caenorhabditis
elegans) 		PF01156
(IU_nuc_hydro) 		4 GLY A  41
VAL A  45
PHE A  36
ILE A  52
 None
 1.12A 4xv2B-5mj7A:
undetectable		 4xv2B-5mj7A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n94 CG9323, ISOFORM A

(Drosophila
melanogaster) 		no annotation 4 GLY A 423
VAL A 544
PHE A 475
ILE A 498
 None
 1.10A 4xv2B-5n94A:
undetectable		 4xv2B-5n94A:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ols RHAMNOGALACTURONAN
LYASE

(Bacteroides
thetaiotaomicron) 		no annotation 4 GLY A 231
VAL A 258
PHE A 183
ILE A 193
 None
 1.09A 4xv2B-5olsA:
undetectable		 4xv2B-5olsA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tch TRYPTOPHAN SYNTHASE
BETA CHAIN

(Mycobacterium
tuberculosis) 		PF00291
(PALP) 		4 GLY B 176
VAL B 173
PHE B 188
ILE B 184
 None
 1.03A 4xv2B-5tchB:
undetectable		 4xv2B-5tchB:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u09 CANNABINOID RECEPTOR
1,GLGA GLYCOGEN
SYNTHASE

(Homo sapiens;
Pyrococcus
abyssi) 		PF00001
(7tm_1)
PF00534
(Glycos_transf_1) 		4 GLY A1039
VAL A1048
PHE A1035
ILE A1116
 None
 1.15A 4xv2B-5u09A:
undetectable		 4xv2B-5u09A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xap PROTEIN TRANSLOCASE
SUBUNIT SECD

(Deinococcus
radiodurans) 		PF02355
(SecD_SecF)
PF07549
(Sec_GG) 		4 GLY A 299
VAL A 357
PHE A 311
ILE A 307
 OLC  A 807 ( 4.5A)
None
None
None
 1.10A 4xv2B-5xapA:
undetectable		 4xv2B-5xapA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmb PANTOTHENATE KINASE

(Mycobacterium
tuberculosis) 		no annotation 4 GLY A 168
VAL A  89
PHE A 218
ILE A  92
 None
 1.14A 4xv2B-5xmbA:
undetectable		 4xv2B-5xmbA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Komagataella
phaffii) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 GLY B 282
VAL B 284
PHE B 325
ILE B 276
 None
 1.05A 4xv2B-5xogB:
undetectable		 4xv2B-5xogB:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi RIBOSOMAL PROTEIN
S3AE, PUTATIVE

(Trichomonas
vaginalis) 		PF01015
(Ribosomal_S3Ae) 		4 GLY B 205
VAL B 136
PHE B 184
ILE B 208
 None
 1.14A 4xv2B-5xyiB:
undetectable		 4xv2B-5xyiB:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6q EXOSOME RNA HELICASE
MTR4

(Homo sapiens) 		no annotation 4 GLY M 533
VAL M 535
PHE M 485
ILE M 390
 None
 1.07A 4xv2B-6d6qM:
undetectable		 4xv2B-6d6qM:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6e9p -

(-) 		no annotation 4 GLY A 100
VAL A  49
PHE A  16
ILE A  55
 None
 1.13A 4xv2B-6e9pA:
undetectable		 4xv2B-6e9pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eio ANTIFREEZE PROTEIN

(uncultured
bacterium) 		no annotation 4 GLY A  79
VAL A  66
PHE A 206
ILE A 222
 None
 0.90A 4xv2B-6eioA:
undetectable		 4xv2B-6eioA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f34 AMINO ACID
TRANSPORTER

(Geobacillus
kaustophilus) 		no annotation 4 GLY A  38
VAL A 317
PHE A 230
ILE A 234
 None
ARG  A 501 (-4.7A)
None
ARG  A 501 (-3.7A)
 1.13A 4xv2B-6f34A:
undetectable		 4xv2B-6f34A:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f9n PRE-MRNA 3' END
PROCESSING PROTEIN
WDR33

(Homo sapiens) 		no annotation 4 GLY B 244
VAL B 247
PHE B 272
ILE B 270
 None
 1.15A 4xv2B-6f9nB:
undetectable		 4xv2B-6f9nB:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fa5 PUTATIVE MRNA
SPLICING FACTOR

(Chaetomium
thermophilum) 		no annotation 4 GLY A 507
VAL A 629
PHE A 558
ILE A 581
 None
None
ADP  A1001 (-3.3A)
None
 1.02A 4xv2B-6fa5A:
undetectable		 4xv2B-6fa5A:
12.94