SIMILAR PATTERNS OF AMINO ACIDS FOR 4XV2_B_P06B801_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cm8 PHOSPHORYLATED MAP
KINASE P38-GAMMA

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  54
LYS A  56
LEU A  78
ASP A 171
PHE A 172
 ANP  A 400 (-3.3A)
ANP  A 400 (-2.9A)
None
MG  A 402 (-2.3A)
None
 0.85A 4xv2B-1cm8A:
21.6		 4xv2B-1cm8A:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4l CELL DIVISION
PROTEIN KINASE 5

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  31
LYS A  33
LEU A  55
CYH A  83
PHE A 145
 None
 0.90A 4xv2B-1h4lA:
18.1		 4xv2B-1h4lA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 ALA A 220
LYS A 222
THR A 266
ASP A 332
PHE A 333
 None
 0.88A 4xv2B-1k9aA:
27.8		 4xv2B-1k9aA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 ALA A 185
LYS A 187
LEU A 206
LEU A 226
ASP A 550
 ADP  A 810 (-3.3A)
ADP  A 810 (-3.1A)
None
ADP  A 810 (-4.4A)
ADP  A 810 ( 3.0A)
 0.86A 4xv2B-1q8yA:
21.2		 4xv2B-1q8yA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		7 ALA A  55
LYS A  57
LEU A  80
CYH A 108
GLY A 168
ASP A 169
PHE A 170
 None
 0.92A 4xv2B-1u5qA:
24.5		 4xv2B-1u5qA:
29.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  36
LYS A  38
CYH A  87
ASP A 148
PHE A 149
 HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
HYM  A 400 (-4.2A)
HYM  A 400 (-3.9A)
None
 0.67A 4xv2B-1zltA:
14.5		 4xv2B-1zltA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  40
LYS A  42
LEU A  68
ASP A 161
PHE A 162
 None
 0.84A 4xv2B-1zwsA:
24.2		 4xv2B-1zwsA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		6 ALA A 626
LEU A 647
CYH A 791
PHE A 842
GLY A 852
PHE A 854
 GOL  A 998 ( 3.7A)
None
GOL  A 998 (-4.3A)
GOL  A 998 ( 4.2A)
None
None
 0.93A 4xv2B-1zy4A:
22.3		 4xv2B-1zy4A:
28.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2a1a INTERFERON-INDUCED,
DOUBLE-STRANDED
RNA-ACTIVATED
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 LYS B 296
CYH B 369
PHE B 421
GLY B 431
ASP B 432
PHE B 433
 None
 0.86A 4xv2B-2a1aB:
22.1		 4xv2B-2a1aB:
30.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  40
LYS A  42
LEU A  68
ASP A 161
PHE A 162
 GOL  A3001 (-3.5A)
None
None
None
None
 0.71A 4xv2B-2a2aA:
24.2		 4xv2B-2a2aA:
25.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA X  37
LYS X  39
THR X  82
ASP X 148
PHE X 149
 STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
STU  X 902 (-4.1A)
STU  X 902 (-3.6A)
None
 0.71A 4xv2B-2dq7X:
21.8		 4xv2B-2dq7X:
32.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 184
LYS A 186
LEU A 205
ASP A 320
PHE A 321
 None
 0.75A 4xv2B-2eu9A:
22.1		 4xv2B-2eu9A:
24.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 ALA A  55
LEU A  80
CYH A 108
GLY A 168
ASP A 169
PHE A 170
 STU  A 400 (-3.2A)
None
STU  A 400 (-4.0A)
None
STU  A 400 (-3.6A)
None
 0.79A 4xv2B-2gcdA:
25.8		 4xv2B-2gcdA:
30.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6l MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  47
LYS A  49
PHE A 159
GLY A 170
PHE A 172
 None
 0.66A 4xv2B-2i6lA:
23.6		 4xv2B-2i6lA:
27.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		6 ALA A 452
LYS A 454
CYH A 502
GLY A 563
ASP A 564
PHE A 565
 4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 (-4.1A)
None
4ST  A1687 (-4.7A)
None
 1.01A 4xv2B-2j0jA:
28.8		 4xv2B-2j0jA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgz CELL DIVISION
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  31
LYS A  33
LEU A  55
ASP A 145
PHE A 146
 None
 0.97A 4xv2B-2jgzA:
24.2		 4xv2B-2jgzA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		5 ALA A 452
LYS A 454
CYH A 502
GLY A 563
PHE A 565
 BII  A1687 (-3.5A)
BII  A1687 (-2.9A)
BII  A1687 (-4.1A)
BII  A1687 ( 3.9A)
None
 0.82A 4xv2B-2jkmA:
28.6		 4xv2B-2jkmA:
28.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 614
LYS A 616
THR A 663
CYH A 666
GLY A 795
ASP A 796
 None
 0.90A 4xv2B-2ogvA:
25.6		 4xv2B-2ogvA:
28.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		5 ALA A  46
LYS A  48
LEU A  77
ASP A 167
PHE A 168
 ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
None
MN  A 382 (-2.0A)
None
 0.92A 4xv2B-2phkA:
23.8		 4xv2B-2phkA:
28.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 ALA A  34
LYS A  36
GLY A 150
ASP A 151
PHE A 152
 AGS  A3001 (-3.5A)
AGS  A3001 (-3.4A)
None
AGS  A3001 (-2.8A)
None
 0.91A 4xv2B-2pmiA:
22.0		 4xv2B-2pmiA:
27.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmo SER/THR PROTEIN
KINASE

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		5 ALA X  53
LYS X  55
LEU X 101
ASP X 190
PHE X 191
 HMD  X 400 (-3.5A)
HMD  X 400 (-4.2A)
HMD  X 400 (-4.2A)
HMD  X 400 (-3.7A)
None
 0.65A 4xv2B-2pmoX:
22.4		 4xv2B-2pmoX:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 215
LYS A 217
LEU A 245
THR A 265
ASP A 339
PHE A 340
 ADE  A 488 (-3.2A)
None
ADE  A 488 ( 4.5A)
ADE  A 488 (-4.3A)
None
None
 0.87A 4xv2B-2qluA:
25.6		 4xv2B-2qluA:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qr7 RIBOSOMAL PROTEIN S6
KINASE ALPHA-3

(Mus musculus) 		PF00069
(Pkinase) 		6 ALA A 449
LYS A 451
LEU A 467
THR A 493
ASP A 561
PHE A 562
 None
 0.79A 4xv2B-2qr7A:
20.0		 4xv2B-2qr7A:
25.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  40
LYS A  42
LEU A  68
ASP A 161
PHE A 162
 ADP  A1303 (-3.5A)
ADP  A1303 (-2.7A)
None
MG  A1304 ( 2.8A)
None
 0.85A 4xv2B-2w4kA:
24.0		 4xv2B-2w4kA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnt RIBOSOMAL PROTEIN S6
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 445
LYS A 447
LEU A 463
THR A 489
ASP A 557
PHE A 558
 None
 0.98A 4xv2B-2wntA:
20.6		 4xv2B-2wntA:
26.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yab DEATH-ASSOCIATED
PROTEIN KINASE 2

(Mus musculus) 		PF00069
(Pkinase) 		5 ALA A  40
LYS A  42
LEU A  68
ASP A 161
PHE A 162
 AMP  A1302 (-3.6A)
AMP  A1302 (-2.8A)
None
AMP  A1302 (-3.1A)
None
 0.81A 4xv2B-2yabA:
24.2		 4xv2B-2yabA:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2w WEE1-LIKE PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 326
CYH A 379
PHE A 433
GLY A 462
ASP A 463
 770  A 901 (-3.5A)
770  A 901 (-3.9A)
770  A 901 (-4.0A)
None
770  A 901 (-3.8A)
 0.62A 4xv2B-2z2wA:
23.1		 4xv2B-2z2wA:
27.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z8c INSULIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A1028
LYS A1030
GLY A1149
ASP A1150
PHE A1151
 S91  A   1 (-3.2A)
S91  A   1 ( 4.2A)
None
None
None
 0.70A 4xv2B-2z8cA:
27.3		 4xv2B-2z8cA:
30.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqr DEATH-ASSOCIATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  40
LYS A  42
LEU A  68
ASP A 161
PHE A 162
 4RB  A 401 (-3.3A)
4RB  A 401 ( 2.8A)
None
GOL  A 503 ( 3.1A)
None
 0.76A 4xv2B-3bqrA:
22.7		 4xv2B-3bqrA:
28.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 220
LYS A 222
THR A 266
ASP A 332
PHE A 333
 None
 0.88A 4xv2B-3d7uA:
28.4		 4xv2B-3d7uA:
30.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  65
LYS A  67
LEU A  93
ASP A 186
PHE A 187
 985  A   1 (-3.5A)
985  A   1 ( 2.8A)
MG  A 314 ( 4.8A)
985  A   1 ( 4.0A)
None
 0.78A 4xv2B-3f2aA:
18.1		 4xv2B-3f2aA:
25.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		5 ALA A 665
LYS A 667
THR A 713
ASP A 778
PHE A 779
 None
 0.72A 4xv2B-3kulA:
23.0		 4xv2B-3kulA:
32.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lij CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		5 ALA A  89
LYS A  91
LEU A 113
ASP A 205
PHE A 206
 ANP  A 522 (-3.6A)
ANP  A 522 (-3.5A)
None
MG  A 521 ( 3.6A)
None
 0.68A 4xv2B-3lijA:
25.3		 4xv2B-3lijA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		5 ALA A 700
LYS A 702
CYH A 748
ASP A 828
PHE A 829
 ADP  A2101 (-3.5A)
ADP  A2101 (-2.7A)
ADP  A2101 (-4.2A)
SR  A2103 (-2.6A)
None
 0.68A 4xv2B-3lj0A:
23.8		 4xv2B-3lj0A:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llt SERINE/THREONINE
KINASE-1, PFLAMMER

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		5 ALA A 579
LYS A 581
LEU A 600
ASP A 720
PHE A 721
 ANP  A 877 ( 3.7A)
ANP  A 877 (-2.7A)
None
ANP  A 877 (-2.9A)
None
 0.97A 4xv2B-3lltA:
21.7		 4xv2B-3lltA:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi9 CELL DIVISION
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  46
LYS A  48
LEU A  70
CYH A 106
ASP A 167
PHE A 168
 None
 0.83A 4xv2B-3mi9A:
17.5		 4xv2B-3mi9A:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  70
LYS A  72
LEU A  95
ASP A 184
PHE A 185
 XFE  A 351 (-3.2A)
None
None
None
None
 0.97A 4xv2B-3mvjA:
22.0		 4xv2B-3mvjA:
27.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ALA A 373
LEU A 397
LEU A 406
THR A 421
TRP A 423
CYH A 424
PHE A 475
GLY A 485
PHE A 487
 SM5  A   1 (-3.6A)
None
None
SM5  A   1 (-4.4A)
SM5  A   1 (-4.3A)
SM5  A   1 ( 4.4A)
SM5  A   1 (-3.0A)
None
None
 0.77A 4xv2B-3omvA:
35.4		 4xv2B-3omvA:
72.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 373
LEU A 406
TRP A 423
CYH A 424
PHE A 475
GLY A 485
ASP A 486
PHE A 487
 SM5  A   1 (-3.6A)
None
SM5  A   1 (-4.3A)
SM5  A   1 ( 4.4A)
SM5  A   1 (-3.0A)
None
SM5  A   1 (-3.5A)
None
 0.99A 4xv2B-3omvA:
35.4		 4xv2B-3omvA:
72.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 373
LYS A 375
LEU A 397
THR A 421
PHE A 475
GLY A 485
PHE A 487
 SM5  A   1 (-3.6A)
SM5  A   1 (-3.5A)
None
SM5  A   1 (-4.4A)
SM5  A   1 (-3.0A)
None
None
 0.89A 4xv2B-3omvA:
35.4		 4xv2B-3omvA:
72.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		5 ALA A 576
LYS A 578
THR A 625
ASP A 694
PHE A 695
 STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
STU  A   1 (-4.1A)
STU  A   1 (-3.5A)
None
 0.85A 4xv2B-3ppzA:
29.7		 4xv2B-3ppzA:
38.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3q4t ACTIVIN RECEPTOR
TYPE-2A

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 217
LYS A 219
LEU A 247
THR A 267
ASP A 340
PHE A 341
 TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
None
TAK  A   2 (-3.5A)
None
None
 0.79A 4xv2B-3q4tA:
25.5		 4xv2B-3q4tA:
30.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 ALA A  84
LYS A  86
LEU A 119
THR A 144
ASP A 211
PHE A 212
 ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
ANP  A1634 (-4.6A)
MG  A 529 (-2.2A)
None
 0.71A 4xv2B-3q5iA:
21.8		 4xv2B-3q5iA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q60 ROP5B

(Toxoplasma
gondii) 		PF14531
(Kinase-like) 		5 ALA A 261
LEU A 304
PHE A 396
GLY A 406
ASP A 407
 ATP  A 600 (-3.6A)
ATP  A 600 ( 4.8A)
ATP  A 600 (-4.4A)
None
MG  A 602 ( 2.5A)
 0.96A 4xv2B-3q60A:
18.2		 4xv2B-3q60A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		7 ALA B 616
LYS B 618
CYH B 889
PHE B 942
GLY B 952
ASP B 953
PHE B 954
 None
 0.70A 4xv2B-3qd2B:
22.7		 4xv2B-3qd2B:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		7 ALA B 616
LYS B 618
LEU B 639
PHE B 942
GLY B 952
ASP B 953
PHE B 954
 None
 0.83A 4xv2B-3qd2B:
22.7		 4xv2B-3qd2B:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s95 LIM DOMAIN KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LYS A 368
LEU A 397
THR A 413
ASP A 478
PHE A 479
 STU  A   1 (-3.1A)
STU  A   1 (-4.6A)
STU  A   1 (-3.9A)
STU  A   1 ( 4.2A)
None
 0.84A 4xv2B-3s95A:
25.1		 4xv2B-3s95A:
29.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A1978
LYS A1980
LEU A2010
GLY A2101
ASP A2102
PHE A2103
 VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
VGH  A3000 (-4.8A)
VGH  A3000 (-3.5A)
None
None
 0.80A 4xv2B-3zbfA:
28.3		 4xv2B-3zbfA:
31.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  31
LYS A  33
LEU A  54
ASP A 143
PHE A 144
 38R  A 350 (-3.4A)
38R  A 350 (-2.9A)
None
NA  A 353 ( 2.5A)
None
 0.80A 4xv2B-3zduA:
23.1		 4xv2B-3zduA:
28.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 649
LYS A 651
THR A 697
ASP A 762
PHE A 763
 None
 0.70A 4xv2B-3zfxA:
28.4		 4xv2B-3zfxA:
32.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  80
LYS A  82
CYH A 133
PHE A 183
GLY A 193
ASP A 194
PHE A 195
 939  A1331 (-3.5A)
939  A1331 (-2.6A)
939  A1331 (-4.0A)
939  A1331 (-4.0A)
None
939  A1331 (-3.1A)
None
 0.65A 4xv2B-4a4lA:
24.7		 4xv2B-4a4lA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  31
LYS A  33
LEU A  55
CYH A  83
ASP A 144
PHE A 145
 D15  A 500 (-3.4A)
D15  A 500 ( 4.1A)
None
D15  A 500 (-4.3A)
D15  A 500 (-3.7A)
None
 1.02A 4xv2B-4aguA:
24.4		 4xv2B-4aguA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 586
LEU A 608
GLY A 709
ASP A 710
PHE A 711
 LTI  A1839 (-3.3A)
None
LTI  A1839 (-3.4A)
None
None
 0.84A 4xv2B-4at3A:
27.9		 4xv2B-4at3A:
29.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 ALA A 104
LYS A 106
LEU A 129
ASP A 219
PHE A 220
 EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
None
None
None
 0.87A 4xv2B-4aw2A:
20.2		 4xv2B-4aw2A:
21.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 121
LYS A 123
THR A 169
ASP A 234
PHE A 235
 30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
30K  A1365 (-3.8A)
30K  A1365 (-3.3A)
None
 0.89A 4xv2B-4aw5A:
28.4		 4xv2B-4aw5A:
32.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  89
LYS A  91
CYH A 142
PHE A 192
GLY A 202
ASP A 203
PHE A 204
 9ZP  A1333 (-3.5A)
None
9ZP  A1333 (-4.1A)
9ZP  A1333 (-3.6A)
9ZP  A1333 ( 4.4A)
None
None
 0.72A 4xv2B-4b6lA:
24.5		 4xv2B-4b6lA:
28.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		5 ALA A 267
LYS A 269
LEU A 292
ASP A 382
PHE A 383
 None
 0.91A 4xv2B-4c0tA:
22.5		 4xv2B-4c0tA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e93 TYROSINE-PROTEIN
KINASE FES/FPS

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		5 ALA A 588
LYS A 590
LEU A 611
ASP A 701
PHE A 702
 GUI  A 901 (-3.4A)
GUI  A 901 (-2.8A)
None
GUI  A 901 ( 4.1A)
None
 0.96A 4xv2B-4e93A:
29.5		 4xv2B-4e93A:
26.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  36
LYS A  38
LEU A  59
CYH A  89
ASP A 157
PHE A 158
 BX7  A 401 (-3.4A)
BX7  A 401 ( 4.0A)
None
BX7  A 401 (-4.1A)
BX7  A 401 ( 3.7A)
None
 0.66A 4xv2B-4eutA:
21.1		 4xv2B-4eutA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  36
LYS A  38
LEU A  59
CYH A  89
ASP A 157
PHE A 158
 BX7  A 401 (-3.4A)
BX7  A 401 (-3.5A)
None
BX7  A 401 (-4.1A)
BX7  A 401 (-3.6A)
None
 0.77A 4xv2B-4euuA:
23.4		 4xv2B-4euuA:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ez5 CYCLIN-DEPENDENT
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  41
LYS A  43
LEU A  65
ASP A 163
PHE A 164
 0RS  A 900 ( 3.7A)
0RS  A 900 (-3.3A)
None
0RS  A 900 (-3.6A)
None
 0.89A 4xv2B-4ez5A:
24.0		 4xv2B-4ez5A:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f99 CELL DIVISION CYCLE
7-RELATED PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  88
LYS A  90
LEU A 108
ASP A 196
PHE A 197
 ADP  A 601 (-3.5A)
ADP  A 601 (-2.6A)
None
MG  A 602 ( 3.1A)
None
 0.93A 4xv2B-4f99A:
15.8		 4xv2B-4f99A:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A1148
LYS A1150
GLY A1269
ASP A1270
PHE A1271
 0UV  A1501 (-3.4A)
0UV  A1501 (-3.7A)
0UV  A1501 (-4.5A)
0UV  A1501 ( 4.2A)
None
 0.80A 4xv2B-4fodA:
27.1		 4xv2B-4fodA:
28.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 ALA A 880
LYS A 882
GLY A 993
ASP A 994
PHE A 995
 IZA  A2001 (-3.4A)
IZA  A2001 ( 4.7A)
None
IZA  A2001 ( 4.5A)
None
 0.90A 4xv2B-4gl9A:
17.6		 4xv2B-4gl9A:
30.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 109
LYS A 111
CYH A 162
PHE A 212
GLY A 222
ASP A 223
PHE A 224
 1C7  A 401 (-3.2A)
1C7  A 401 ( 4.7A)
1C7  A 401 (-4.1A)
1C7  A 401 (-4.0A)
None
None
None
 0.72A 4xv2B-4i6fA:
23.0		 4xv2B-4i6fA:
28.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 156
LYS A 158
THR A 205
GLY A 269
ASP A 270
PHE A 271
 1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 (-3.2A)
None
None
1G0  A 401 ( 4.8A)
 1.19A 4xv2B-4id7A:
27.3		 4xv2B-4id7A:
29.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7b POLO-LIKE KINASE

(Danio rerio) 		PF00069
(Pkinase) 		7 ALA A  66
LYS A  68
CYH A 119
PHE A 169
GLY A 179
ASP A 180
PHE A 181
 None
 0.71A 4xv2B-4j7bA:
24.5		 4xv2B-4j7bA:
27.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		5 ALA A  99
LYS A 101
CYH A 149
ASP A 213
PHE A 214
 STU  A 601 (-3.3A)
STU  A 601 (-3.9A)
STU  A 601 (-4.2A)
STU  A 601 (-4.3A)
None
 0.86A 4xv2B-4mvfA:
21.7		 4xv2B-4mvfA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1o RIBONUCLEASE L

(Sus scrofa) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		5 ALA A 388
LYS A 390
CYH A 435
ASP A 500
PHE A 501
 None
 0.85A 4xv2B-4o1oA:
16.1		 4xv2B-4o1oA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1o RIBONUCLEASE L

(Sus scrofa) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		5 ALA A 388
LYS A 390
LEU A 406
CYH A 435
PHE A 501
 None
 0.78A 4xv2B-4o1oA:
16.1		 4xv2B-4o1oA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  67
LYS A  69
THR A 123
CYH A 126
ASP A 191
PHE A 192
 SIN  A 401 ( 3.7A)
None
None
SIN  A 401 (-4.3A)
None
None
 0.71A 4xv2B-4o38A:
21.0		 4xv2B-4o38A:
26.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oav PROTEIN (RNASE L)

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		6 ALA B 390
LYS B 392
LEU B 408
CYH B 437
ASP B 503
PHE B 504
 ACP  B 801 (-3.2A)
ACP  B 801 (-2.8A)
None
ACP  B 801 (-4.5A)
MG  B 803 (-1.8A)
None
 0.89A 4xv2B-4oavB:
17.2		 4xv2B-4oavB:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 928
LEU A 951
GLY A1040
ASP A1041
PHE A1042
 2TT  A1202 ( 3.9A)
None
2TT  A1202 (-3.4A)
2TT  A1202 (-4.6A)
None
 0.96A 4xv2B-4oliA:
27.0		 4xv2B-4oliA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ylj DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 1A

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 186
LYS A 188
LEU A 207
ASP A 307
PHE A 308
 4E1  A 505 (-3.5A)
4E1  A 505 (-2.7A)
None
4E1  A 505 (-3.6A)
None
 0.80A 4xv2B-4yljA:
21.3		 4xv2B-4yljA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 ALA A  55
LYS A  57
LEU A  80
THR A 105
ASP A 172
PHE A 173
 ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
ADP  A 506 ( 4.6A)
ADP  A 506 ( 2.4A)
None
 0.85A 4xv2B-4ysjA:
25.0		 4xv2B-4ysjA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 275
LYS A 277
LEU A 305
THR A 325
ASP A 397
PHE A 398
 STU  A 601 (-3.1A)
STU  A 601 (-2.4A)
STU  A 601 ( 3.8A)
STU  A 601 ( 3.7A)
STU  A 601 (-3.0A)
None
 0.59A 4xv2B-5e8yA:
25.2		 4xv2B-5e8yA:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax) 		PF00027
(cNMP_binding)
PF00069
(Pkinase) 		5 ALA A 561
LYS A 563
THR A 611
ASP A 675
PHE A 676
 4ZS  A 901 ( 3.8A)
4ZS  A 901 (-3.9A)
4ZS  A 901 (-3.2A)
None
4ZS  A 901 (-4.9A)
 0.85A 4xv2B-5ezrA:
19.7		 4xv2B-5ezrA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 928
LYS A 930
GLY A1040
ASP A1041
PHE A1042
 5U3  A1200 (-3.5A)
None
5U3  A1200 ( 4.9A)
5U3  A1200 ( 4.9A)
None
 0.72A 4xv2B-5f1zA:
26.7		 4xv2B-5f1zA:
28.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fd2 SERINE/THREONINE-PRO
TEIN KINASE B-RAF

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 ALA A 481
LYS A 483
LEU A 505
LEU A 514
THR A 529
TRP A 531
CYH A 532
PHE A 583
GLY A 593
PHE A 595
 5XJ  A 801 (-3.1A)
5XJ  A 801 (-3.8A)
5XJ  A 801 (-3.8A)
5XJ  A 801 (-4.5A)
5XJ  A 801 (-3.4A)
5XJ  A 801 (-4.4A)
5XJ  A 801 (-4.6A)
5XJ  A 801 (-4.3A)
5XJ  A 801 ( 3.7A)
5XJ  A 801 (-3.7A)
 0.76A 4xv2B-5fd2A:
36.1		 4xv2B-5fd2A:
90.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fd2 SERINE/THREONINE-PRO
TEIN KINASE B-RAF

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 ALA A 481
LYS A 483
LEU A 505
LEU A 514
THR A 529
TRP A 531
PHE A 583
GLY A 593
ASP A 594
PHE A 595
 5XJ  A 801 (-3.1A)
5XJ  A 801 (-3.8A)
5XJ  A 801 (-3.8A)
5XJ  A 801 (-4.5A)
5XJ  A 801 (-3.4A)
5XJ  A 801 (-4.4A)
5XJ  A 801 (-4.3A)
5XJ  A 801 ( 3.7A)
None
5XJ  A 801 (-3.7A)
 0.80A 4xv2B-5fd2A:
36.1		 4xv2B-5fd2A:
90.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A  43
LYS A  45
LEU A  57
THR A  82
ASP A 151
 032  A 401 (-3.2A)
032  A 401 (-4.4A)
032  A 401 ( 4.7A)
032  A 401 (-3.7A)
032  A 401 (-4.6A)
 0.64A 4xv2B-5hesA:
7.5		 4xv2B-5hesA:
31.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		5 ALA A  43
LYS A  45
LEU A  68
ASP A 157
PHE A 158
 STU  A 601 (-3.3A)
STU  A 601 ( 4.4A)
None
STU  A 601 (-3.5A)
None
 0.84A 4xv2B-5isoA:
25.7		 4xv2B-5isoA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  43
LYS A  45
CYH A  93
ASP A 154
PHE A 155
 6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
TPO  A 145 (-4.1A)
6G2  A 901 (-3.4A)
None
 0.71A 4xv2B-5j5tA:
22.7		 4xv2B-5j5tA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 417
LYS A 419
GLY A 532
ASP A 533
PHE A 534
 GUI  A 701 ( 3.9A)
GUI  A 701 (-3.1A)
GUI  A 701 ( 4.7A)
GUI  A 701 ( 4.8A)
None
 0.80A 4xv2B-5jznA:
23.5		 4xv2B-5jznA:
26.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 417
LYS A 419
LEU A 440
GLY A 532
PHE A 534
 GUI  A 701 ( 3.9A)
GUI  A 701 (-3.1A)
None
GUI  A 701 ( 4.7A)
None
 0.79A 4xv2B-5jznA:
23.5		 4xv2B-5jznA:
26.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 228
LYS A 230
LEU A 263
CYH A 286
PHE A 350
 6UY  A 501 (-3.4A)
6UY  A 501 (-4.0A)
None
6UY  A 501 (-4.3A)
None
 0.78A 4xv2B-5ko1A:
26.1		 4xv2B-5ko1A:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 176
LYS A 178
LEU A 197
ASP A 295
PHE A 296
 7A7  A 501 (-3.5A)
7A7  A 501 (-3.5A)
None
7A7  A 501 (-3.2A)
None
 0.95A 4xv2B-5lxdA:
20.5		 4xv2B-5lxdA:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o2c SERINE/THREONINE-PRO
TEIN KINASE WNK3

(Homo sapiens) 		PF00069
(Pkinase)
PF12202
(OSR1_C) 		5 ALA A 174
LEU A 198
THR A 227
PHE A 282
GLY A 293
 GOL  A 604 ( 3.8A)
None
GOL  A 604 (-3.9A)
GOL  A 604 ( 4.5A)
GOL  A 604 ( 4.6A)
 0.53A 4xv2B-5o2cA:
25.9		 4xv2B-5o2cA:
28.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		no annotation 5 ALA A  65
LYS A  67
LEU A  93
ASP A 186
PHE A 187
 7LK  A 401 (-3.3A)
None
None
None
None
 0.82A 4xv2B-5turA:
22.9		 4xv2B-5turA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo sapiens) 		no annotation 5 ALA A  38
LYS A  40
CYH A  89
ASP A 150
PHE A 151
 7LV  A 401 (-3.4A)
7LV  A 401 (-3.0A)
7LV  A 401 (-4.3A)
7LV  A 401 (-4.2A)
None
 0.80A 4xv2B-5tvtA:
23.6		 4xv2B-5tvtA:
27.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 137
THR A 187
CYH A 190
PHE A 240
GLY A 250
ASP A 251
 H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
H8H  A 401 (-4.3A)
None
EDO  A 402 ( 2.9A)
 0.67A 4xv2B-5vcxA:
22.6		 4xv2B-5vcxA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 137
THR A 187
PHE A 240
GLY A 250
ASP A 251
PHE A 252
 H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
None
EDO  A 402 ( 2.9A)
None
 0.65A 4xv2B-5vcxA:
22.6		 4xv2B-5vcxA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vdk WEE1-LIKE PROTEIN
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 239
CYH A 292
PHE A 346
GLY A 379
ASP A 380
 8X7  A 501 ( 3.7A)
8X7  A 501 (-3.8A)
8X7  A 501 (-3.7A)
None
8X7  A 501 (-4.8A)
 0.74A 4xv2B-5vdkA:
22.8		 4xv2B-5vdkA:
27.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vo1 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 12

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 150
LYS A 152
CYH A 193
ASP A 254
PHE A 255
 9FS  A 501 (-3.4A)
None
9FS  A 501 (-4.3A)
None
None
 0.92A 4xv2B-5vo1A:
27.3		 4xv2B-5vo1A:
36.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y86 DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 3

(Homo sapiens) 		no annotation 5 ALA A 236
LYS A 238
LEU A 257
ASP A 355
PHE A 356
 HRM  A 601 (-3.5A)
HRM  A 601 (-3.3A)
None
HRM  A 601 (-4.7A)
None
 0.86A 4xv2B-5y86A:
20.8		 4xv2B-5y86A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3e CYCLIN-DEPENDENT
KINASE 12

(Homo sapiens) 		no annotation 5 ALA A 754
LYS A 756
LEU A 778
ASP A 877
PHE A 878
 CJM  A1102 (-3.1A)
None
None
MG  A1101 (-2.5A)
None
 0.69A 4xv2B-6b3eA:
24.1		 4xv2B-6b3eA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1

(Homo sapiens) 		no annotation 5 ALA A 237
LYS A 239
GLY A 357
ASP A 358
PHE A 359
 DL1  A 601 (-3.4A)
DL1  A 601 ( 4.1A)
DL1  A 601 ( 4.8A)
DL1  A 601 (-3.1A)
None
 0.96A 4xv2B-6bfnA:
24.8		 4xv2B-6bfnA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 6 ALA A 906
LYS A 908
LEU A 929
GLY A1020
ASP A1021
PHE A1022
 ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
None
MG  A1203 (-1.8A)
None
 1.02A 4xv2B-6c7yA:
17.3		 4xv2B-6c7yA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2

(Homo sapiens) 		no annotation 5 ALA A 191
LYS A 193
LEU A 212
ASP A 327
PHE A 328
 3NG  A 501 (-3.3A)
3NG  A 501 (-3.0A)
None
3NG  A 501 (-4.5A)
None
 0.93A 4xv2B-6fylA:
22.2		 4xv2B-6fylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 5 ALA A 189
LYS A 191
LEU A 210
ASP A 325
PHE A 326
 3NG  A 501 (-3.5A)
3NG  A 501 (-2.7A)
None
3NG  A 501 (-4.3A)
None
 0.92A 4xv2B-6fyvA:
22.3		 4xv2B-6fyvA:
undetectable