SIMILAR PATTERNS OF AMINO ACIDS FOR 4XV2_A_P06A801

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cm8 PHOSPHORYLATED MAP
KINASE P38-GAMMA

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  41
ALA A  54
LYS A  56
ASP A 171
PHE A 172
 ANP  A 400 (-4.1A)
ANP  A 400 (-3.3A)
ANP  A 400 (-2.9A)
MG  A 402 (-2.3A)
None
 0.70A 4xv2A-1cm8A:
21.4		 4xv2A-1cm8A:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 VAL A 209
ALA A 220
LYS A 222
THR A 266
ASP A 332
PHE A 333
 None
 0.92A 4xv2A-1k9aA:
27.6		 4xv2A-1k9aA:
22.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1py5 TGF-BETA RECEPTOR
TYPE I

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		5 VAL A 219
ALA A 230
LYS A 232
LEU A 260
ASP A 351
 PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 (-3.9A)
PY1  A 700 (-4.2A)
PY1  A 700 (-2.7A)
 0.73A 4xv2A-1py5A:
25.1		 4xv2A-1py5A:
30.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 603
ALA A 621
LYS A 623
THR A 670
CYH A 673
 STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.2A)
STI  A   3 (-4.5A)
 0.25A 4xv2A-1t46A:
21.9		 4xv2A-1t46A:
30.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 VAL A  42
ALA A  55
CYH A 108
GLY A 168
ASP A 169
PHE A 170
 None
 0.76A 4xv2A-1u5qA:
24.2		 4xv2A-1u5qA:
29.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 VAL A  42
LYS A  57
CYH A 108
GLY A 168
ASP A 169
PHE A 170
 None
 0.93A 4xv2A-1u5qA:
24.2		 4xv2A-1u5qA:
29.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  23
ALA A  36
LYS A  38
CYH A  87
ASP A 148
PHE A 149
 HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
HYM  A 400 (-4.2A)
HYM  A 400 (-3.9A)
None
 0.74A 4xv2A-1zltA:
15.3		 4xv2A-1zltA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  27
ALA A  40
LYS A  42
ASP A 161
PHE A 162
 None
 0.74A 4xv2A-1zwsA:
24.2		 4xv2A-1zwsA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		6 VAL A 613
ALA A 626
CYH A 791
PHE A 842
GLY A 852
PHE A 854
 None
GOL  A 998 ( 3.7A)
GOL  A 998 (-4.3A)
GOL  A 998 ( 4.2A)
None
None
 0.81A 4xv2A-1zy4A:
22.3		 4xv2A-1zy4A:
28.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2a1a INTERFERON-INDUCED,
DOUBLE-STRANDED
RNA-ACTIVATED
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL B 281
LYS B 296
CYH B 369
PHE B 421
GLY B 431
ASP B 432
PHE B 433
 None
 0.89A 4xv2A-2a1aB:
22.1		 4xv2A-2a1aB:
30.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  27
ALA A  40
LYS A  42
ASP A 161
PHE A 162
 None
GOL  A3001 (-3.5A)
None
None
None
 0.62A 4xv2A-2a2aA:
24.1		 4xv2A-2a2aA:
25.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL X  25
ALA X  37
LYS X  39
THR X  82
ASP X 148
PHE X 149
 STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
STU  X 902 (-4.1A)
STU  X 902 (-3.6A)
None
 0.73A 4xv2A-2dq7X:
27.4		 4xv2A-2dq7X:
32.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A 170
ALA A 184
LYS A 186
ASP A 320
PHE A 321
 None
 0.72A 4xv2A-2eu9A:
21.6		 4xv2A-2eu9A:
24.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 VAL A  42
ALA A  55
CYH A 108
GLY A 168
ASP A 169
PHE A 170
 STU  A 400 ( 4.8A)
STU  A 400 (-3.2A)
STU  A 400 (-4.0A)
None
STU  A 400 (-3.6A)
None
 0.69A 4xv2A-2gcdA:
25.5		 4xv2A-2gcdA:
30.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 256
ALA A 269
LYS A 271
THR A 315
ASP A 381
 GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.4A)
GIN  A 600 (-4.9A)
 0.60A 4xv2A-2hz0A:
27.7		 4xv2A-2hz0A:
30.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6l MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  34
ALA A  47
LYS A  49
PHE A 159
GLY A 170
PHE A 172
 None
 0.77A 4xv2A-2i6lA:
23.4		 4xv2A-2i6lA:
27.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		6 VAL A 436
ALA A 452
LYS A 454
CYH A 502
GLY A 563
ASP A 564
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 (-4.1A)
None
4ST  A1687 (-4.7A)
 0.93A 4xv2A-2j0jA:
28.4		 4xv2A-2j0jA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		6 VAL A 436
ALA A 452
LYS A 454
CYH A 502
GLY A 563
PHE A 565
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 (-4.1A)
None
None
 0.74A 4xv2A-2j0jA:
28.4		 4xv2A-2j0jA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		6 VAL A 436
ALA A 452
LYS A 454
CYH A 502
GLY A 563
PHE A 565
 BII  A1687 ( 4.7A)
BII  A1687 (-3.5A)
BII  A1687 (-2.9A)
BII  A1687 (-4.1A)
BII  A1687 ( 3.9A)
None
 0.87A 4xv2A-2jkmA:
28.0		 4xv2A-2jkmA:
28.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 596
ALA A 614
LYS A 616
THR A 663
CYH A 666
GLY A 795
 None
 0.54A 4xv2A-2ogvA:
25.1		 4xv2A-2ogvA:
28.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmo SER/THR PROTEIN
KINASE

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		5 ALA X  53
LYS X  55
LEU X 101
ASP X 190
PHE X 191
 HMD  X 400 (-3.5A)
HMD  X 400 (-4.2A)
HMD  X 400 (-4.2A)
HMD  X 400 (-3.7A)
None
 0.72A 4xv2A-2pmoX:
22.0		 4xv2A-2pmoX:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 204
ALA A 215
LYS A 217
LEU A 245
THR A 265
ASP A 339
PHE A 340
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
ADE  A 488 ( 4.5A)
ADE  A 488 (-4.3A)
None
None
 0.85A 4xv2A-2qluA:
25.3		 4xv2A-2qluA:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qr7 RIBOSOMAL PROTEIN S6
KINASE ALPHA-3

(Mus musculus) 		PF00069
(Pkinase) 		5 ALA A 449
LYS A 451
THR A 493
ASP A 561
PHE A 562
 None
 0.71A 4xv2A-2qr7A:
20.1		 4xv2A-2qr7A:
25.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  27
ALA A  40
LYS A  42
ASP A 161
PHE A 162
 ADP  A1303 (-4.0A)
ADP  A1303 (-3.5A)
ADP  A1303 (-2.7A)
MG  A1304 ( 2.8A)
None
 0.74A 4xv2A-2w4kA:
23.9		 4xv2A-2w4kA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2w WEE1-LIKE PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 313
ALA A 326
CYH A 379
PHE A 433
GLY A 462
ASP A 463
 770  A 901 ( 4.7A)
770  A 901 (-3.5A)
770  A 901 (-3.9A)
770  A 901 (-4.0A)
None
770  A 901 (-3.8A)
 0.66A 4xv2A-2z2wA:
23.0		 4xv2A-2z2wA:
27.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z8c INSULIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A1010
ALA A1028
LYS A1030
GLY A1149
ASP A1150
PHE A1151
 S91  A   1 ( 4.9A)
S91  A   1 (-3.2A)
S91  A   1 ( 4.2A)
None
None
None
 0.72A 4xv2A-2z8cA:
26.9		 4xv2A-2z8cA:
30.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 209
ALA A 220
LYS A 222
THR A 266
ASP A 332
PHE A 333
 None
 0.92A 4xv2A-3d7uA:
23.1		 4xv2A-3d7uA:
30.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  52
ALA A  65
LYS A  67
ASP A 186
PHE A 187
 985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 ( 2.8A)
985  A   1 ( 4.0A)
None
 0.68A 4xv2A-3f2aA:
18.0		 4xv2A-3f2aA:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igo CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		5 VAL A  90
ALA A 103
LYS A 105
ASP A 219
PHE A 220
 ANP  A 610 (-3.9A)
ANP  A 610 ( 3.7A)
ANP  A 610 (-2.8A)
ANP  A 610 ( 2.7A)
None
 0.60A 4xv2A-3igoA:
22.4		 4xv2A-3igoA:
25.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 VAL A 649
ALA A 665
LYS A 667
THR A 713
ASP A 778
PHE A 779
 None
 0.88A 4xv2A-3kulA:
28.3		 4xv2A-3kulA:
32.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lij CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		5 VAL A  76
ALA A  89
LYS A  91
ASP A 205
PHE A 206
 ANP  A 522 (-4.1A)
ANP  A 522 (-3.6A)
ANP  A 522 (-3.5A)
MG  A 521 ( 3.6A)
None
 0.67A 4xv2A-3lijA:
25.5		 4xv2A-3lijA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		6 VAL A 689
ALA A 700
LYS A 702
CYH A 748
ASP A 828
PHE A 829
 ADP  A2101 (-4.5A)
ADP  A2101 (-3.5A)
ADP  A2101 (-2.7A)
ADP  A2101 (-4.2A)
SR  A2103 (-2.6A)
None
 0.81A 4xv2A-3lj0A:
18.2		 4xv2A-3lj0A:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		5 VAL A 218
ALA A 229
LEU A 259
THR A 279
ASP A 350
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
LDN  A   1 (-3.8A)
LDN  A   1 (-3.9A)
 0.48A 4xv2A-3mdyA:
25.3		 4xv2A-3mdyA:
29.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi9 CELL DIVISION
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  33
ALA A  46
LYS A  48
CYH A 106
ASP A 167
PHE A 168
 None
 0.97A 4xv2A-3mi9A:
22.6		 4xv2A-3mi9A:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 216
ALA A 227
LYS A 229
LEU A 257
THR A 277
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
None
LDN  A 600 (-4.0A)
 0.44A 4xv2A-3my0A:
24.4		 4xv2A-3my0A:
26.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 373
LYS A 375
THR A 421
PHE A 475
GLY A 485
PHE A 487
 SM5  A   1 (-3.6A)
SM5  A   1 (-3.5A)
SM5  A   1 (-4.4A)
SM5  A   1 (-3.0A)
None
None
 0.83A 4xv2A-3omvA:
35.1		 4xv2A-3omvA:
72.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL A 363
ALA A 373
LEU A 406
THR A 421
TRP A 423
CYH A 424
PHE A 475
GLY A 485
PHE A 487
 SM5  A   1 (-4.0A)
SM5  A   1 (-3.6A)
None
SM5  A   1 (-4.4A)
SM5  A   1 (-4.3A)
SM5  A   1 ( 4.4A)
SM5  A   1 (-3.0A)
None
None
 0.78A 4xv2A-3omvA:
35.1		 4xv2A-3omvA:
72.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL A 363
ALA A 373
LEU A 406
TRP A 423
CYH A 424
PHE A 475
GLY A 485
ASP A 486
PHE A 487
 SM5  A   1 (-4.0A)
SM5  A   1 (-3.6A)
None
SM5  A   1 (-4.3A)
SM5  A   1 ( 4.4A)
SM5  A   1 (-3.0A)
None
SM5  A   1 (-3.5A)
None
 1.09A 4xv2A-3omvA:
35.1		 4xv2A-3omvA:
72.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pls MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A1096
ALA A1112
LYS A1114
LEU A1144
ASP A1226
PHE A1227
 ANP  A1358 (-4.4A)
ANP  A1358 ( 3.8A)
ANP  A1358 (-3.2A)
None
MG  A   1 ( 3.2A)
None
 1.33A 4xv2A-3plsA:
27.7		 4xv2A-3plsA:
31.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3q4t ACTIVIN RECEPTOR
TYPE-2A

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 206
ALA A 217
LYS A 219
LEU A 247
THR A 267
ASP A 340
PHE A 341
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
None
TAK  A   2 (-3.5A)
None
None
 0.86A 4xv2A-3q4tA:
25.2		 4xv2A-3q4tA:
30.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 VAL A  71
ALA A  84
LYS A  86
THR A 144
ASP A 211
PHE A 212
 ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
ANP  A1634 (-4.6A)
MG  A 529 (-2.2A)
None
 0.68A 4xv2A-3q5iA:
21.7		 4xv2A-3q5iA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q60 ROP5B

(Toxoplasma
gondii) 		PF14531
(Kinase-like) 		6 ALA A 261
LYS A 263
LEU A 304
PHE A 396
GLY A 406
ASP A 407
 ATP  A 600 (-3.6A)
MLI  A 601 ( 2.8A)
ATP  A 600 ( 4.8A)
ATP  A 600 (-4.4A)
None
MG  A 602 ( 2.5A)
 1.39A 4xv2A-3q60A:
18.2		 4xv2A-3q60A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q60 ROP5B

(Toxoplasma
gondii) 		PF14531
(Kinase-like) 		6 VAL A 248
ALA A 261
LYS A 263
LEU A 304
PHE A 396
GLY A 406
 ATP  A 600 (-4.3A)
ATP  A 600 (-3.6A)
MLI  A 601 ( 2.8A)
ATP  A 600 ( 4.8A)
ATP  A 600 (-4.4A)
None
 0.90A 4xv2A-3q60A:
18.2		 4xv2A-3q60A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		7 ALA B 616
LYS B 618
CYH B 889
PHE B 942
GLY B 952
ASP B 953
PHE B 954
 None
 0.71A 4xv2A-3qd2B:
22.7		 4xv2A-3qd2B:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		7 VAL B 603
ALA B 616
CYH B 889
PHE B 942
GLY B 952
ASP B 953
PHE B 954
 None
 0.75A 4xv2A-3qd2B:
22.7		 4xv2A-3qd2B:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3she MAP KINASE-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  58
ALA A  71
LYS A  73
ASP A 187
PHE A 188
 I85  A 350 (-4.9A)
I85  A 350 (-3.3A)
I85  A 350 (-2.8A)
I85  A 350 (-3.3A)
None
 0.62A 4xv2A-3sheA:
19.9		 4xv2A-3sheA:
23.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A1978
LYS A1980
LEU A2010
GLY A2101
ASP A2102
PHE A2103
 VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
VGH  A3000 (-4.8A)
VGH  A3000 (-3.5A)
None
None
 0.85A 4xv2A-3zbfA:
22.3		 4xv2A-3zbfA:
31.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A1959
ALA A1978
LYS A1980
LEU A2010
GLY A2101
PHE A2103
 None
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
VGH  A3000 (-4.8A)
VGH  A3000 (-3.5A)
None
 0.85A 4xv2A-3zbfA:
22.3		 4xv2A-3zbfA:
31.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 633
ALA A 649
LYS A 651
THR A 697
ASP A 762
PHE A 763
 None
 0.88A 4xv2A-3zfxA:
28.2		 4xv2A-3zfxA:
32.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  80
LYS A  82
CYH A 133
PHE A 183
GLY A 193
ASP A 194
PHE A 195
 939  A1331 (-3.5A)
939  A1331 (-2.6A)
939  A1331 (-4.0A)
939  A1331 (-4.0A)
None
939  A1331 (-3.1A)
None
 0.68A 4xv2A-4a4lA:
18.4		 4xv2A-4a4lA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  18
ALA A  31
LYS A  33
CYH A  83
PHE A 145
 D15  A 500 (-4.6A)
D15  A 500 (-3.4A)
D15  A 500 ( 4.1A)
D15  A 500 (-4.3A)
None
 0.66A 4xv2A-4aguA:
15.8		 4xv2A-4aguA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  89
LYS A  91
CYH A 142
PHE A 192
GLY A 202
ASP A 203
PHE A 204
 9ZP  A1333 (-3.5A)
None
9ZP  A1333 (-4.1A)
9ZP  A1333 (-3.6A)
9ZP  A1333 ( 4.4A)
None
None
 0.74A 4xv2A-4b6lA:
24.2		 4xv2A-4b6lA:
28.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		5 VAL A 222
ALA A 233
LYS A 235
LEU A 263
THR A 283
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
 0.41A 4xv2A-4c02A:
24.3		 4xv2A-4c02A:
28.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  23
ALA A  36
LYS A  38
CYH A  89
ASP A 157
PHE A 158
 BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
BX7  A 401 ( 4.0A)
BX7  A 401 (-4.1A)
BX7  A 401 ( 3.7A)
None
 0.56A 4xv2A-4eutA:
13.8		 4xv2A-4eutA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  23
ALA A  36
LYS A  38
CYH A  89
ASP A 157
PHE A 158
 BX7  A 401 ( 4.6A)
BX7  A 401 (-3.4A)
BX7  A 401 (-3.5A)
BX7  A 401 (-4.1A)
BX7  A 401 (-3.6A)
None
 0.69A 4xv2A-4euuA:
17.2		 4xv2A-4euuA:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ez5 CYCLIN-DEPENDENT
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  27
ALA A  41
LYS A  43
ASP A 163
PHE A 164
 None
0RS  A 900 ( 3.7A)
0RS  A 900 (-3.3A)
0RS  A 900 (-3.6A)
None
 0.74A 4xv2A-4ez5A:
24.5		 4xv2A-4ez5A:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f99 CELL DIVISION CYCLE
7-RELATED PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  72
ALA A  88
LYS A  90
ASP A 196
PHE A 197
 ADP  A 601 (-4.0A)
ADP  A 601 (-3.5A)
ADP  A 601 (-2.6A)
MG  A 602 ( 3.1A)
None
 0.64A 4xv2A-4f99A:
15.8		 4xv2A-4f99A:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A1130
ALA A1148
LYS A1150
GLY A1269
ASP A1270
PHE A1271
 0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 (-3.7A)
0UV  A1501 (-4.5A)
0UV  A1501 ( 4.2A)
None
 0.93A 4xv2A-4fodA:
26.4		 4xv2A-4fodA:
28.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 606
ALA A 619
CYH A 890
PHE A 943
GLY A 953
PHE A 955
 924  A1101 ( 4.8A)
924  A1101 (-3.5A)
924  A1101 (-3.9A)
924  A1101 ( 4.2A)
924  A1101 (-4.6A)
924  A1101 ( 4.4A)
 0.78A 4xv2A-4g34A:
23.6		 4xv2A-4g34A:
27.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 606
ALA A 619
LYS A 621
CYH A 890
GLY A 953
PHE A 955
 924  A1101 ( 4.8A)
924  A1101 (-3.5A)
None
924  A1101 (-3.9A)
924  A1101 (-4.6A)
924  A1101 ( 4.4A)
 0.92A 4xv2A-4g34A:
23.6		 4xv2A-4g34A:
27.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 606
CYH A 890
PHE A 943
GLY A 953
ASP A 954
PHE A 955
 924  A1101 ( 4.8A)
924  A1101 (-3.9A)
924  A1101 ( 4.2A)
924  A1101 (-4.6A)
924  A1101 (-3.7A)
924  A1101 ( 4.4A)
 1.43A 4xv2A-4g34A:
23.6		 4xv2A-4g34A:
27.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 VAL A 863
ALA A 880
GLY A 993
ASP A 994
PHE A 995
 None
IZA  A2001 (-3.4A)
None
IZA  A2001 ( 4.5A)
None
 0.65A 4xv2A-4gl9A:
25.8		 4xv2A-4gl9A:
30.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		6 VAL A 140
ALA A 156
LYS A 158
GLY A 269
ASP A 270
PHE A 271
 None
 1.10A 4xv2A-4hzsA:
27.1		 4xv2A-4hzsA:
28.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		6 VAL A 140
ALA A 156
LYS A 158
THR A 205
GLY A 269
PHE A 271
 None
 1.17A 4xv2A-4hzsA:
27.1		 4xv2A-4hzsA:
28.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 109
LYS A 111
CYH A 162
PHE A 212
GLY A 222
ASP A 223
PHE A 224
 1C7  A 401 (-3.2A)
1C7  A 401 ( 4.7A)
1C7  A 401 (-4.1A)
1C7  A 401 (-4.0A)
None
None
None
 0.78A 4xv2A-4i6fA:
22.7		 4xv2A-4i6fA:
28.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 156
LYS A 158
THR A 205
GLY A 269
ASP A 270
PHE A 271
 1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 (-3.2A)
None
None
1G0  A 401 ( 4.8A)
 1.23A 4xv2A-4id7A:
27.0		 4xv2A-4id7A:
29.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 140
ALA A 156
LYS A 158
THR A 205
GLY A 269
PHE A 271
 1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 (-3.2A)
None
1G0  A 401 ( 4.8A)
 0.80A 4xv2A-4id7A:
27.0		 4xv2A-4id7A:
29.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7b POLO-LIKE KINASE

(Danio rerio) 		PF00069
(Pkinase) 		7 ALA A  66
LYS A  68
CYH A 119
PHE A 169
GLY A 179
ASP A 180
PHE A 181
 None
 0.72A 4xv2A-4j7bA:
24.3		 4xv2A-4j7bA:
27.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Mus musculus) 		PF00069
(Pkinase) 		6 VAL A  23
ALA A  36
LYS A  38
CYH A  89
ASP A 157
PHE A 158
 None
SU6  A 701 (-3.4A)
None
SU6  A 701 (-3.8A)
None
None
 0.97A 4xv2A-4jlcA:
20.3		 4xv2A-4jlcA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		6 VAL A  36
ALA A  49
LYS A  51
LEU A  74
THR A  95
PHE A 162
 ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
None
ANP  A 401 (-3.8A)
None
 1.04A 4xv2A-4m69A:
27.1		 4xv2A-4m69A:
27.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 VAL A  86
ALA A  99
LYS A 101
CYH A 149
ASP A 213
PHE A 214
 STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-3.9A)
STU  A 601 (-4.2A)
STU  A 601 (-4.3A)
None
 1.01A 4xv2A-4mvfA:
21.3		 4xv2A-4mvfA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  54
ALA A  67
LYS A  69
THR A 123
CYH A 126
ASP A 191
PHE A 192
 None
SIN  A 401 ( 3.7A)
None
None
SIN  A 401 (-4.3A)
None
None
 0.74A 4xv2A-4o38A:
20.9		 4xv2A-4o38A:
26.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 911
ALA A 928
GLY A1040
ASP A1041
PHE A1042
 2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
2TT  A1202 (-3.4A)
2TT  A1202 (-4.6A)
None
 0.71A 4xv2A-4oliA:
26.8		 4xv2A-4oliA:
19.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 477
ALA A 488
LYS A 490
THR A 539
ASP A 606
PHE A 607
 None
4CV  A 801 (-3.5A)
4CV  A 801 (-3.9A)
4CV  A 801 (-2.8A)
4CV  A 801 (-3.5A)
None
 0.97A 4xv2A-4yffA:
26.7		 4xv2A-4yffA:
32.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 VAL A  42
ALA A  55
LYS A  57
THR A 105
ASP A 172
PHE A 173
 ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
ADP  A 506 ( 4.6A)
ADP  A 506 ( 2.4A)
None
 0.85A 4xv2A-4ysjA:
25.2		 4xv2A-4ysjA:
22.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  30
ALA A  44
LYS A  46
CYH A  95
PHE A 166
 51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
GOL  A 404 ( 3.1A)
51W  A 401 (-3.9A)
None
 0.68A 4xv2A-5ci7A:
23.0		 4xv2A-5ci7A:
30.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 258
ALA A 275
LYS A 277
LEU A 305
THR A 325
ASP A 397
PHE A 398
 STU  A 601 (-4.0A)
STU  A 601 (-3.1A)
STU  A 601 (-2.4A)
STU  A 601 ( 3.8A)
STU  A 601 ( 3.7A)
STU  A 601 (-3.0A)
None
 0.65A 4xv2A-5e8yA:
25.0		 4xv2A-5e8yA:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax) 		PF00027
(cNMP_binding)
PF00069
(Pkinase) 		6 VAL A 548
ALA A 561
LYS A 563
THR A 611
ASP A 675
PHE A 676
 4ZS  A 901 (-4.8A)
4ZS  A 901 ( 3.8A)
4ZS  A 901 (-3.9A)
4ZS  A 901 (-3.2A)
None
4ZS  A 901 (-4.9A)
 0.88A 4xv2A-5ezrA:
19.5		 4xv2A-5ezrA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 911
ALA A 928
LYS A 930
GLY A1040
ASP A1041
PHE A1042
 5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
5U3  A1200 ( 4.9A)
5U3  A1200 ( 4.9A)
None
 0.71A 4xv2A-5f1zA:
20.1		 4xv2A-5f1zA:
28.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fd2 SERINE/THREONINE-PRO
TEIN KINASE B-RAF

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 VAL A 471
ALA A 481
LYS A 483
LEU A 514
THR A 529
TRP A 531
CYH A 532
PHE A 583
GLY A 593
PHE A 595
 5XJ  A 801 (-4.6A)
5XJ  A 801 (-3.1A)
5XJ  A 801 (-3.8A)
5XJ  A 801 (-4.5A)
5XJ  A 801 (-3.4A)
5XJ  A 801 (-4.4A)
5XJ  A 801 (-4.6A)
5XJ  A 801 (-4.3A)
5XJ  A 801 ( 3.7A)
5XJ  A 801 (-3.7A)
 0.70A 4xv2A-5fd2A:
30.7		 4xv2A-5fd2A:
90.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fd2 SERINE/THREONINE-PRO
TEIN KINASE B-RAF

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 VAL A 471
ALA A 481
LYS A 483
LEU A 514
THR A 529
TRP A 531
PHE A 583
GLY A 593
ASP A 594
PHE A 595
 5XJ  A 801 (-4.6A)
5XJ  A 801 (-3.1A)
5XJ  A 801 (-3.8A)
5XJ  A 801 (-4.5A)
5XJ  A 801 (-3.4A)
5XJ  A 801 (-4.4A)
5XJ  A 801 (-4.3A)
5XJ  A 801 ( 3.7A)
None
5XJ  A 801 (-3.7A)
 0.78A 4xv2A-5fd2A:
30.7		 4xv2A-5fd2A:
90.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 607
ALA A 625
LYS A 627
THR A 674
CYH A 677
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.2A)
748  A1001 (-4.5A)
 0.36A 4xv2A-5grnA:
21.8		 4xv2A-5grnA:
28.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A  30
ALA A  43
LYS A  45
THR A  82
ASP A 151
 032  A 401 (-4.4A)
032  A 401 (-3.2A)
032  A 401 (-4.4A)
032  A 401 (-3.7A)
032  A 401 (-4.6A)
 0.62A 4xv2A-5hesA:
26.7		 4xv2A-5hesA:
31.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		5 VAL A  30
ALA A  43
LYS A  45
ASP A 157
PHE A 158
 STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 ( 4.4A)
STU  A 601 (-3.5A)
None
 0.70A 4xv2A-5isoA:
25.4		 4xv2A-5isoA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  30
ALA A  43
LYS A  45
CYH A  93
ASP A 154
PHE A 155
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
TPO  A 145 (-4.1A)
6G2  A 901 (-3.4A)
None
 0.68A 4xv2A-5j5tA:
22.4		 4xv2A-5j5tA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 404
ALA A 417
LYS A 419
GLY A 532
ASP A 533
PHE A 534
 GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
GUI  A 701 (-3.1A)
GUI  A 701 ( 4.7A)
GUI  A 701 ( 4.8A)
None
 0.90A 4xv2A-5jznA:
23.5		 4xv2A-5jznA:
26.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o2c SERINE/THREONINE-PRO
TEIN KINASE WNK3

(Homo sapiens) 		PF00069
(Pkinase)
PF12202
(OSR1_C) 		5 VAL A 161
ALA A 174
THR A 227
PHE A 282
GLY A 293
 None
GOL  A 604 ( 3.8A)
GOL  A 604 (-3.9A)
GOL  A 604 ( 4.5A)
GOL  A 604 ( 4.6A)
 0.59A 4xv2A-5o2cA:
26.1		 4xv2A-5o2cA:
28.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		no annotation 5 VAL A  52
ALA A  65
LYS A  67
ASP A 186
PHE A 187
 7LK  A 401 (-4.9A)
7LK  A 401 (-3.3A)
None
None
None
 0.69A 4xv2A-5turA:
22.8		 4xv2A-5turA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo sapiens) 		no annotation 6 VAL A  25
ALA A  38
LYS A  40
CYH A  89
ASP A 150
PHE A 151
 7LV  A 401 ( 4.6A)
7LV  A 401 (-3.4A)
7LV  A 401 (-3.0A)
7LV  A 401 (-4.3A)
7LV  A 401 (-4.2A)
None
 0.91A 4xv2A-5tvtA:
23.0		 4xv2A-5tvtA:
27.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis) 		no annotation 5 VAL A  25
ALA A  38
LYS A  40
ASP A 156
PHE A 157
 G93  A 301 (-3.4A)
G93  A 301 ( 3.7A)
G93  A 301 (-3.0A)
G93  A 301 ( 3.2A)
G93  A 301 (-4.8A)
 0.74A 4xv2A-5u94A:
21.6		 4xv2A-5u94A:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 124
ALA A 137
THR A 187
CYH A 190
PHE A 240
GLY A 250
ASP A 251
 H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
H8H  A 401 (-4.3A)
None
EDO  A 402 ( 2.9A)
 0.76A 4xv2A-5vcxA:
18.5		 4xv2A-5vcxA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 124
ALA A 137
THR A 187
PHE A 240
GLY A 250
ASP A 251
PHE A 252
 H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
None
EDO  A 402 ( 2.9A)
None
 0.81A 4xv2A-5vcxA:
18.5		 4xv2A-5vcxA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vdk WEE1-LIKE PROTEIN
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A 226
ALA A 239
CYH A 292
PHE A 346
GLY A 379
 8X7  A 501 ( 4.5A)
8X7  A 501 ( 3.7A)
8X7  A 501 (-3.8A)
8X7  A 501 (-3.7A)
None
 0.51A 4xv2A-5vdkA:
16.4		 4xv2A-5vdkA:
27.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 5 VAL A  32
ALA A  45
LYS A  47
LEU A  79
THR A  95
 9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.3A)
9WS  A 401 (-4.9A)
9WS  A 401 (-3.2A)
 0.41A 4xv2A-5w5jA:
27.1		 4xv2A-5w5jA:
28.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x1t PPKA-294

(Serratia sp.
FS14) 		no annotation 6 PHE A  86
VAL A  37
ALA A  50
LEU A 102
THR A 118
ASP A 183
 None
ADP  A 401 ( 4.5A)
ADP  A 401 (-3.4A)
None
ADP  A 401 (-4.1A)
None
 1.11A 4xv2A-5x1tA:
22.1		 4xv2A-5x1tA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3e CYCLIN-DEPENDENT
KINASE 12

(Homo sapiens) 		no annotation 5 VAL A 741
ALA A 754
LYS A 756
ASP A 877
PHE A 878
 None
CJM  A1102 (-3.1A)
None
MG  A1101 (-2.5A)
None
 0.59A 4xv2A-6b3eA:
23.7		 4xv2A-6b3eA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1

(Homo sapiens) 		no annotation 6 VAL A 226
ALA A 237
LYS A 239
GLY A 357
ASP A 358
PHE A 359
 None
DL1  A 601 (-3.4A)
DL1  A 601 ( 4.1A)
DL1  A 601 ( 4.8A)
DL1  A 601 (-3.1A)
None
 1.01A 4xv2A-6bfnA:
24.4		 4xv2A-6bfnA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0t CGMP-DEPENDENT
PROTEIN KINASE 1

(Homo sapiens) 		no annotation 6 VAL A 374
ALA A 388
LYS A 390
CYH A 441
ASP A 502
PHE A 503
 EE4  A 701 (-4.4A)
EE4  A 701 (-3.3A)
DMS  A 702 (-3.5A)
EE4  A 701 (-4.6A)
DMS  A 702 ( 3.1A)
None
 0.85A 4xv2A-6c0tA:
17.6		 4xv2A-6c0tA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 6 VAL A 889
ALA A 906
LYS A 908
GLY A1020
ASP A1021
PHE A1022
 ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
MG  A1203 (-1.8A)
None
 0.68A 4xv2A-6c7yA:
25.8		 4xv2A-6c7yA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cth CONCANAVALIN A-LIKE
LECTIN PROTEIN
KINASE FAMILY
PROTEIN

(Theobroma cacao) 		no annotation 6 PHE A 280
VAL A 283
ALA A 296
LYS A 298
GLY A 410
PHE A 412
 None
FE7  A 601 ( 4.3A)
FE7  A 601 (-3.3A)
FE7  A 601 (-3.6A)
FE7  A 601 ( 4.1A)
None
 0.94A 4xv2A-6cthA:
23.1		 4xv2A-6cthA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3r HDLP (HISTONE
DEACETYLASE-LIKE
PROTEIN)

(Aquifex
aeolicus) 		PF00850
(Hist_deacetyl) 		4 GLY A 140
LEU A  69
PHE A 100
ILE A 144
 TSN  A 502 ( 3.9A)
None
None
None
 0.95A 4xv2A-1c3rA:
0.0		 4xv2A-1c3rA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1clx XYLANASE A

(Cellvibrio
japonicus) 		PF00331
(Glyco_hydro_10) 		4 GLY A  19
LEU A 331
PHE A 327
ILE A 307
 None
 0.97A 4xv2A-1clxA:
0.0		 4xv2A-1clxA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cy9 DNA TOPOISOMERASE I

(Escherichia
coli) 		PF01131
(Topoisom_bac) 		4 GLY A 315
LEU A 289
PHE A 284
ILE A 394
 None
 0.96A 4xv2A-1cy9A:
undetectable		 4xv2A-1cy9A:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cyi CYTOCHROME C6

(Chlamydomonas
reinhardtii) 		PF13442
(Cytochrome_CBB3) 		4 GLY A  56
LEU A  36
PHE A  44
ILE A  49
 None
HEM  A 200 (-4.6A)
None
HEM  A 200 ( 4.3A)
 0.95A 4xv2A-1cyiA:
undetectable		 4xv2A-1cyiA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hw2 FATTY ACID
METABOLISM REGULATOR
PROTEIN

(Escherichia
coli) 		PF00392
(GntR)
PF07840
(FadR_C) 		4 GLY A 203
LEU A 152
PHE A 112
ILE A 113
 None
 0.92A 4xv2A-1hw2A:
1.8		 4xv2A-1hw2A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i9g HYPOTHETICAL PROTEIN
RV2118C

(Mycobacterium
tuberculosis) 		PF08704
(GCD14)
PF14801
(GCD14_N) 		4 GLY A  47
LEU A  15
PHE A  62
ILE A  40
 None
 0.91A 4xv2A-1i9gA:
0.0		 4xv2A-1i9gA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jn0 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
A

(Spinacia
oleracea) 		no annotation 4 GLY O  34
LEU O  16
PHE O  15
ILE O   5
 None
 0.94A 4xv2A-1jn0O:
0.0		 4xv2A-1jn0O:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k1d D-HYDANTOINASE

(Geobacillus
stearothermophilus) 		PF01979
(Amidohydro_1) 		4 GLY A  84
LEU A  61
PHE A  74
ILE A  89
 None
 0.87A 4xv2A-1k1dA:
0.0		 4xv2A-1k1dA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1

(Mus musculus) 		PF01979
(Amidohydro_1) 		4 GLY A  99
LEU A  76
PHE A  89
ILE A 104
 None
 0.86A 4xv2A-1kcxA:
0.0		 4xv2A-1kcxA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lkd BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE

(Paraburkholderia
xenovorans) 		PF00903
(Glyoxalase) 		4 GLY A 143
LEU A  29
PHE A  41
ILE A  50
 None
 0.90A 4xv2A-1lkdA:
0.0		 4xv2A-1lkdA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lnz SPO0B-ASSOCIATED
GTP-BINDING PROTEIN

(Bacillus
subtilis) 		PF01018
(GTP1_OBG)
PF01926
(MMR_HSR1) 		4 GLY A 165
LEU A 320
PHE A 307
ILE A 278
 None
 0.86A 4xv2A-1lnzA:
undetectable		 4xv2A-1lnzA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lox 15-LIPOXYGENASE

(Oryctolagus
cuniculus) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 GLY A  11
LEU A 109
PHE A  95
ILE A  81
 None
 0.92A 4xv2A-1loxA:
undetectable		 4xv2A-1loxA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mw9 DNA TOPOISOMERASE I

(Escherichia
coli) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		4 GLY X 315
LEU X 289
PHE X 284
ILE X 394
 None
 0.95A 4xv2A-1mw9X:
undetectable		 4xv2A-1mw9X:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n76 LACTOFERRIN

(Homo sapiens) 		PF00405
(Transferrin) 		4 GLY A 124
LEU A 320
PHE A 325
ILE A 328
 CO3  A 695 (-4.0A)
None
None
None
 0.97A 4xv2A-1n76A:
undetectable		 4xv2A-1n76A:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p2f RESPONSE REGULATOR

(Thermotoga
maritima) 		PF00072
(Response_reg)
PF00486
(Trans_reg_C) 		4 GLY A 210
LEU A 157
PHE A 215
ILE A 205
 None
 0.98A 4xv2A-1p2fA:
undetectable		 4xv2A-1p2fA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pn4 PEROXISOMAL
HYDRATASE-DEHYDROGEN
ASE-EPIMERASE

(Candida
tropicalis) 		PF01575
(MaoC_dehydratas) 		4 GLY A 104
LEU A  63
PHE A  66
ILE A 133
 None
 0.98A 4xv2A-1pn4A:
undetectable		 4xv2A-1pn4A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q67 DECAPPING PROTEIN
INVOLVED IN MRNA
DEGRADATION-DCP1P

(Saccharomyces
cerevisiae) 		PF06058
(DCP1) 		4 GLY A  63
LEU A  37
PHE A  24
ILE A  27
 None
 0.70A 4xv2A-1q67A:
undetectable		 4xv2A-1q67A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qo8 FLAVOCYTOCHROME C3
FUMARATE REDUCTASE

(Shewanella
frigidimarina) 		PF00890
(FAD_binding_2)
PF14537
(Cytochrom_c3_2) 		4 GLY A 166
LEU A 256
PHE A 134
ILE A 253
 FAD  A 605 (-4.3A)
None
None
None
 0.91A 4xv2A-1qo8A:
undetectable		 4xv2A-1qo8A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rz3 HYPOTHETICAL PROTEIN
RBSTP0775

(Geobacillus
stearothermophilus) 		PF00485
(PRK) 		4 GLY A  50
LEU A  25
PHE A 146
ILE A  14
 None
 0.95A 4xv2A-1rz3A:
undetectable		 4xv2A-1rz3A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sg9 HEMK PROTEIN

(Thermotoga
maritima) 		PF05175
(MTS) 		4 GLY A 136
LEU A 181
PHE A 188
ILE A 194
 None
 0.84A 4xv2A-1sg9A:
undetectable		 4xv2A-1sg9A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tp7 GENOME POLYPROTEIN

(Rhinovirus A) 		PF00680
(RdRP_1) 		4 GLY A 203
LEU A 194
PHE A 195
ILE A 294
 None
 0.98A 4xv2A-1tp7A:
undetectable		 4xv2A-1tp7A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tve HOMOSERINE
DEHYDROGENASE

(Saccharomyces
cerevisiae) 		PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3) 		4 GLY A 289
LEU A 156
PHE A 155
ILE A 323
 None
 0.71A 4xv2A-1tveA:
undetectable		 4xv2A-1tveA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4g GLUTAMATE--CYSTEINE
LIGASE

(Escherichia
coli) 		PF04262
(Glu_cys_ligase) 		4 GLY A 148
LEU A 350
PHE A 349
ILE A 194
 None
 0.74A 4xv2A-1v4gA:
0.9		 4xv2A-1v4gA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w7c LYSYL OXIDASE

(Komagataella
pastoris) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF09248
(DUF1965) 		4 GLY A 541
LEU A 492
PHE A 486
ILE A 364
 None
 0.91A 4xv2A-1w7cA:
undetectable		 4xv2A-1w7cA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x1b CRTF-RELATED PROTEIN

(Chlorobaculum
tepidum) 		PF00891
(Methyltransf_2) 		4 GLY A  78
LEU A  35
PHE A  36
ILE A  73
 None
 0.82A 4xv2A-1x1bA:
undetectable		 4xv2A-1x1bA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y0g PROTEIN YCEI

(Escherichia
coli) 		PF04264
(YceI) 		4 GLY A  50
LEU A 127
PHE A 166
ILE A 161
 None
None
None
8PP  A 320 (-4.8A)
 0.86A 4xv2A-1y0gA:
undetectable		 4xv2A-1y0gA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzv HYPOTHETICAL PROTEIN

(Trypanosoma
cruzi) 		PF00857
(Isochorismatase) 		4 GLY A  49
LEU A 173
PHE A 181
ILE A 184
 None
 0.99A 4xv2A-1yzvA:
undetectable		 4xv2A-1yzvA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zk7 MERCURIC REDUCTASE

(Pseudomonas
aeruginosa) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 GLY A  36
LEU A 276
PHE A 119
ILE A  10
 FAD  A 666 ( 4.6A)
None
None
FAD  A 666 (-4.7A)
 0.90A 4xv2A-1zk7A:
undetectable		 4xv2A-1zk7A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ak3 ADENYLATE KINASE
ISOENZYME-3

(Bos taurus) 		PF00406
(ADK)
PF05191
(ADK_lid) 		4 GLY A  19
LEU A 210
PHE A 209
ILE A 110
 SO4  A 227 (-3.3A)
None
None
None
 0.82A 4xv2A-2ak3A:
undetectable		 4xv2A-2ak3A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4n PROTEIN NAGD

(Escherichia
coli) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 GLY A  91
LEU A  79
PHE A  78
ILE A 141
 None
 0.90A 4xv2A-2c4nA:
undetectable		 4xv2A-2c4nA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfm THERMOSTABLE DNA
LIGASE

(Pyrococcus
furiosus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 GLY A 169
LEU A  30
PHE A  29
ILE A  45
 None
 0.81A 4xv2A-2cfmA:
undetectable		 4xv2A-2cfmA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csq RIM BINDING PROTEIN
2

(Homo sapiens) 		PF07653
(SH3_2) 		4 GLY A   4
LEU A  42
PHE A  44
ILE A  50
 None
 0.98A 4xv2A-2csqA:
undetectable		 4xv2A-2csqA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ekm HYPOTHETICAL PROTEIN
ST1511

(Sulfurisphaera
tokodaii) 		PF04008
(Adenosine_kin) 		4 GLY A  21
LEU A  36
PHE A  45
ILE A  47
 None
 0.99A 4xv2A-2ekmA:
undetectable		 4xv2A-2ekmA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmh ELECTRON TRANSFER
FLAVOPROTEIN-UBIQUIN
ONE OXIDOREDUCTASE

(Sus scrofa) 		PF05187
(ETF_QO)
PF13450
(NAD_binding_8) 		4 GLY A 214
LEU A 415
PHE A 338
ILE A 341
 FAD  A 611 (-3.4A)
None
None
None
 0.89A 4xv2A-2gmhA:
undetectable		 4xv2A-2gmhA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2klb PUTATIVE DIFLAVIN
FLAVOPROTEIN A 3

(Nostoc sp. PCC
7120) 		no annotation 4 GLY A  91
LEU A  36
PHE A   5
ILE A  57
 None
 0.90A 4xv2A-2klbA:
undetectable		 4xv2A-2klbA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oox HYPOTHETICAL PROTEIN
C1556.08C IN
CHROMOSOME I

(Schizosaccharomyces
pombe) 		no annotation 4 GLY G 302
LEU G 276
PHE G 280
ILE G 309
 None
 0.98A 4xv2A-2ooxG:
undetectable		 4xv2A-2ooxG:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca) 		PF04672
(Methyltransf_19) 		4 GLY A 164
LEU A  71
PHE A  70
ILE A 268
 SAM  A 400 (-3.5A)
None
None
None
 0.80A 4xv2A-2qe6A:
undetectable		 4xv2A-2qe6A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zu8 MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE

(Pyrococcus
horikoshii) 		PF09488
(Osmo_MPGsynth) 		4 GLY A 130
LEU A 150
PHE A 264
ILE A 370
 None
 0.84A 4xv2A-2zu8A:
undetectable		 4xv2A-2zu8A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9x SELENOCYSTEINE LYASE

(Rattus
norvegicus) 		PF00266
(Aminotran_5) 		4 GLY A  87
LEU A 267
PHE A 280
ILE A  82
 PLP  A 501 (-3.7A)
None
None
None
 0.94A 4xv2A-3a9xA:
undetectable		 4xv2A-3a9xA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al0 ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B

(Thermotoga
maritima) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N) 		4 GLY B 194
LEU B 177
PHE B 173
ILE B  11
 None
 0.96A 4xv2A-3al0B:
1.3		 4xv2A-3al0B:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3baz HYDROXYPHENYLPYRUVAT
E REDUCTASE

(Plectranthus
scutellarioides) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 GLY A 222
LEU A 116
PHE A 142
ILE A 198
 None
 0.92A 4xv2A-3bazA:
undetectable		 4xv2A-3bazA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bre PROBABLE
TWO-COMPONENT
RESPONSE REGULATOR

(Pseudomonas
aeruginosa) 		PF00072
(Response_reg)
PF00990
(GGDEF) 		4 GLY A 299
LEU A 189
PHE A 312
ILE A 316
 None
 0.86A 4xv2A-3breA:
undetectable		 4xv2A-3breA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3daq DIHYDRODIPICOLINATE
SYNTHASE

(Staphylococcus
aureus) 		PF00701
(DHDPS) 		4 GLY A  98
LEU A   4
PHE A   5
ILE A  76
 None
 0.79A 4xv2A-3daqA:
undetectable		 4xv2A-3daqA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dqz ALPHA-HYDROXYNITRILE
LYASE-LIKE PROTEIN

(Arabidopsis
thaliana) 		PF12697
(Abhydrolase_6) 		4 GLY A  83
LEU A  66
PHE A  94
ILE A  63
 None
 0.98A 4xv2A-3dqzA:
undetectable		 4xv2A-3dqzA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e4e CYTOCHROME P450 2E1

(Homo sapiens) 		PF00067
(p450) 		4 GLY A 137
LEU A 449
PHE A 448
ILE A 341
 None
 0.91A 4xv2A-3e4eA:
undetectable		 4xv2A-3e4eA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyr PHENOXAZINONE
SYNTHASE

(Streptomyces
antibioticus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 GLY A 483
LEU A 519
PHE A 546
ILE A 479
 None
 0.81A 4xv2A-3gyrA:
undetectable		 4xv2A-3gyrA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzd SELENOCYSTEINE LYASE

(Homo sapiens) 		PF00266
(Aminotran_5) 		4 GLY C  98
LEU C 279
PHE C 292
ILE C  94
 PLR  C 500 ( 4.5A)
None
None
None
 0.95A 4xv2A-3gzdC:
undetectable		 4xv2A-3gzdC:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzd SELENOCYSTEINE LYASE

(Homo sapiens) 		PF00266
(Aminotran_5) 		4 GLY C  99
LEU C 279
PHE C 292
ILE C  94
 PLR  C 500 (-3.6A)
None
None
None
 0.92A 4xv2A-3gzdC:
undetectable		 4xv2A-3gzdC:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hc7 GENE 12 PROTEIN

(Mycobacterium
virus D29) 		PF01083
(Cutinase) 		4 GLY A  21
LEU A 251
PHE A 250
ILE A 114
 None
 0.84A 4xv2A-3hc7A:
undetectable		 4xv2A-3hc7A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hi0 PUTATIVE
EXOPOLYPHOSPHATASE

(Agrobacterium
fabrum) 		PF02541
(Ppx-GppA) 		4 GLY A 144
LEU A 247
PHE A 246
ILE A 218
 None
 0.86A 4xv2A-3hi0A:
undetectable		 4xv2A-3hi0A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4t DIPHTHINE SYNTHASE

(Entamoeba
histolytica) 		PF00590
(TP_methylase) 		4 GLY A  83
LEU A 160
PHE A 127
ILE A 117
 None
 0.78A 4xv2A-3i4tA:
undetectable		 4xv2A-3i4tA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5b WSPR RESPONSE
REGULATOR

(Pseudomonas
aeruginosa) 		PF00990
(GGDEF) 		4 GLY A 299
LEU A 189
PHE A 312
ILE A 316
 None
 0.95A 4xv2A-3i5bA:
1.7		 4xv2A-3i5bA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6s SUBTILISIN-LIKE
PROTEASE

(Solanum
lycopersicum) 		PF00082
(Peptidase_S8) 		4 GLY A 173
LEU A 185
PHE A 154
ILE A 147
 None
 0.96A 4xv2A-3i6sA:
undetectable		 4xv2A-3i6sA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ic9 DIHYDROLIPOAMIDE
DEHYDROGENASE

(Colwellia
psychrerythraea) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 GLY A  37
LEU A 276
PHE A 118
ILE A  11
 FAD  A 490 ( 4.2A)
None
None
FAD  A 490 (-4.8A)
 0.81A 4xv2A-3ic9A:
undetectable		 4xv2A-3ic9A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihv SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 GLY A  80
LEU A  66
PHE A  67
ILE A  87
 None
 0.98A 4xv2A-3ihvA:
1.4		 4xv2A-3ihvA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ja6 CHEMOTAXIS PROTEIN
CHEW

(Escherichia
coli) 		PF01584
(CheW) 		4 GLY A 124
LEU A  65
PHE A  93
ILE A 141
 None
 0.99A 4xv2A-3ja6A:
undetectable		 4xv2A-3ja6A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k28 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
2

(Bacillus
anthracis) 		PF00202
(Aminotran_3) 		4 GLY A 336
LEU A 427
PHE A 379
ILE A 346
 None
 0.94A 4xv2A-3k28A:
undetectable		 4xv2A-3k28A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3b RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 2
SUBUNIT BETA

(Escherichia
coli) 		no annotation 4 GLY B 144
LEU B 225
PHE B 156
ILE B 152
 None
 0.98A 4xv2A-3n3bB:
undetectable		 4xv2A-3n3bB:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nbi RECQ-MEDIATED GENOME
INSTABILITY PROTEIN
1

(Homo sapiens) 		PF08585
(RMI1_N) 		4 GLY A 142
LEU A  81
PHE A 175
ILE A  73
 None
 0.95A 4xv2A-3nbiA:
undetectable		 4xv2A-3nbiA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oaj PUTATIVE
RING-CLEAVING
DIOXYGENASE MHQO

(Bacillus
subtilis) 		PF00903
(Glyoxalase) 		4 GLY A 196
LEU A  32
PHE A  51
ILE A  62
 None
 0.92A 4xv2A-3oajA:
undetectable		 4xv2A-3oajA:
20.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 GLY A 358
LEU A 397
PHE A 408
ILE A 419
 None
None
None
SM5  A   1 ( 4.3A)
 0.71A 4xv2A-3omvA:
35.1		 4xv2A-3omvA:
72.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pic CIP2

(Trichoderma
reesei) 		no annotation 4 GLY A 283
LEU A 202
PHE A 414
ILE A 369
 None
 0.98A 4xv2A-3picA:
undetectable		 4xv2A-3picA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rr5 DNA LIGASE

(Thermococcus
sp. 1519) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 GLY A 180
LEU A  41
PHE A  40
ILE A  56
 None
 0.93A 4xv2A-3rr5A:
undetectable		 4xv2A-3rr5A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sfw DIHYDROPYRIMIDINASE

(Brevibacillus
agri) 		PF01979
(Amidohydro_1) 		4 GLY A  84
LEU A  61
PHE A  74
ILE A  89
 None
 0.86A 4xv2A-3sfwA:
undetectable		 4xv2A-3sfwA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sfw DIHYDROPYRIMIDINASE

(Brevibacillus
agri) 		PF01979
(Amidohydro_1) 		4 GLY A  85
LEU A  61
PHE A  74
ILE A  89
 None
 0.95A 4xv2A-3sfwA:
undetectable		 4xv2A-3sfwA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v98 ARACHIDONATE
5-LIPOXYGENASE

(Homo sapiens) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 GLY A  13
LEU A 111
PHE A  97
ILE A  85
 None
 0.88A 4xv2A-3v98A:
undetectable		 4xv2A-3v98A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zs6 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Burkholderia
pseudomallei) 		PF00496
(SBP_bac_5) 		4 GLY A 346
LEU A 527
PHE A 296
ILE A 292
 None
 0.90A 4xv2A-3zs6A:
undetectable		 4xv2A-3zs6A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyo ASPARTYL
AMINOPEPTIDASE

(Homo sapiens) 		PF02127
(Peptidase_M18) 		4 GLY A  92
LEU A  42
PHE A  65
ILE A  73
 None
 0.82A 4xv2A-4dyoA:
undetectable		 4xv2A-4dyoA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e51 HISTIDINE--TRNA
LIGASE

(Burkholderia
thailandensis) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		4 GLY A 310
LEU A 250
PHE A 257
ILE A 171
 HIS  A 501 (-3.3A)
None
None
None
 0.98A 4xv2A-4e51A:
undetectable		 4xv2A-4e51A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eo3 BACTERIOFERRITIN
COMIGRATORY
PROTEIN/NADH
DEHYDROGENASE

(Thermotoga
maritima) 		PF00578
(AhpC-TSA)
PF00881
(Nitroreductase) 		4 GLY A 112
LEU A 134
PHE A  52
ILE A  28
 None
 0.95A 4xv2A-4eo3A:
1.9		 4xv2A-4eo3A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eq5 DNA LIGASE

(Thermococcus
sibiricus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 GLY A 181
LEU A  41
PHE A  40
ILE A  57
 None
 0.93A 4xv2A-4eq5A:
undetectable		 4xv2A-4eq5A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fsp PROBABLE PORIN

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		4 GLY A 185
LEU A 149
PHE A 129
ILE A 117
 C8E  A 406 ( 4.0A)
None
None
None
 0.98A 4xv2A-4fspA:
undetectable		 4xv2A-4fspA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h5i GUANINE
NUCLEOTIDE-EXCHANGE
FACTOR SEC12

(Saccharomyces
cerevisiae) 		no annotation 4 GLY A  30
LEU A  45
PHE A  58
ILE A 333
 None
 0.96A 4xv2A-4h5iA:
undetectable		 4xv2A-4h5iA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ieg RNA-DEPENDENT RNA
POLYMERASE P2

(Pseudomonas
phage phi12) 		no annotation 4 GLY A 510
LEU A 340
PHE A 339
ILE A 465
 None
 0.93A 4xv2A-4iegA:
1.5		 4xv2A-4iegA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kqn D-HYDANTOINASE

(Bacillus sp.
AR9) 		PF01979
(Amidohydro_1) 		4 GLY A  84
LEU A  61
PHE A  74
ILE A  89
 GLY  A  84 ( 0.0A)
LEU  A  61 ( 0.6A)
PHE  A  74 ( 1.3A)
ILE  A  89 ( 0.6A)
 0.83A 4xv2A-4kqnA:
undetectable		 4xv2A-4kqnA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kqn D-HYDANTOINASE

(Bacillus sp.
AR9) 		PF01979
(Amidohydro_1) 		4 GLY A  85
LEU A  61
PHE A  74
ILE A  89
 GLY  A  85 ( 0.0A)
LEU  A  61 ( 0.6A)
PHE  A  74 ( 1.3A)
ILE  A  89 ( 0.6A)
 0.92A 4xv2A-4kqnA:
undetectable		 4xv2A-4kqnA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mmg MRNA INTERFERASE
YAFQ

(Escherichia
coli) 		PF15738
(YafQ_toxin) 		4 GLY A  10
LEU A  90
PHE A  91
ILE A  71
 None
 0.95A 4xv2A-4mmgA:
undetectable		 4xv2A-4mmgA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0q LEU/ILE/VAL-BINDING
PROTEIN HOMOLOG 3

(Brucella
melitensis) 		PF13458
(Peripla_BP_6) 		4 GLY A 215
LEU A 231
PHE A 221
ILE A 166
 None
 0.94A 4xv2A-4n0qA:
undetectable		 4xv2A-4n0qA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nf7 ENDO-1,4-BETA-GLUCAN
ASE CEL5C

(Butyrivibrio
proteoclasticus) 		PF00150
(Cellulase) 		4 GLY A 103
LEU A 137
PHE A 184
ILE A 171
 None
 0.94A 4xv2A-4nf7A:
undetectable		 4xv2A-4nf7A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8u UNCHARACTERIZED
PROTEIN PF2046

(Pyrococcus
furiosus) 		PF13680
(DUF4152) 		4 GLY A 157
LEU A  21
PHE A  25
ILE A 230
 None
 0.95A 4xv2A-4o8uA:
undetectable		 4xv2A-4o8uA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0f SERINE PROTEASE
INHIBITOR 4, ISOFORM
B

(Drosophila
melanogaster) 		PF00079
(Serpin) 		4 GLY A 374
LEU A 281
PHE A 285
ILE A  40
 None
 0.91A 4xv2A-4p0fA:
undetectable		 4xv2A-4p0fA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE

(Mycobacterium
avium) 		PF00289
(Biotin_carb_N)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 GLY A 981
LEU A 921
PHE A 920
ILE A 898
 None
 0.82A 4xv2A-4rcnA:
undetectable		 4xv2A-4rcnA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rul DNA TOPOISOMERASE 1

(Escherichia
coli) 		PF01131
(Topoisom_bac)
PF01396
(zf-C4_Topoisom)
PF01751
(Toprim)
PF08272
(Topo_Zn_Ribbon) 		4 GLY A 315
LEU A 289
PHE A 284
ILE A 394
 None
 0.99A 4xv2A-4rulA:
undetectable		 4xv2A-4rulA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzg SURFACE PROTEIN SPB1

(Streptococcus
agalactiae) 		no annotation 4 GLY A 352
LEU A 421
PHE A 372
ILE A 356
 None
 0.90A 4xv2A-4uzgA:
undetectable		 4xv2A-4uzgA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzr PUTATIVE
UNCHARACTERIZED
PROTEIN PH1500

(Pyrococcus
horikoshii) 		PF02933
(CDC48_2) 		4 GLY A  33
LEU A  11
PHE A  53
ILE A  27
 None
 0.89A 4xv2A-4uzrA:
undetectable		 4xv2A-4uzrA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN

(Escherichia
coli;
Homo sapiens) 		PF00100
(Zona_pellucida)
PF13416
(SBP_bac_8) 		4 GLY A 588
LEU A 579
PHE A 653
ILE A 704
 None
 0.81A 4xv2A-4wrnA:
undetectable		 4xv2A-4wrnA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0t RIBONUCLEASE J

(Streptomyces
coelicolor) 		PF00753
(Lactamase_B)
PF07521
(RMMBL) 		4 GLY A 368
LEU A 225
PHE A 229
ILE A 337
 None
 0.97A 4xv2A-5a0tA:
undetectable		 4xv2A-5a0tA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II SUBUNIT
ALPHA

(Methanothermobacter
marburgensis) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		4 GLY A 224
LEU A 316
PHE A 289
ILE A 104
 None
 0.99A 4xv2A-5a8rA:
undetectable		 4xv2A-5a8rA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d5t UNCHARACTERIZED
PROTEIN MJ0489

(Methanocaldococcus
jannaschii) 		PF06690
(DUF1188) 		4 GLY A  59
LEU A  42
PHE A  41
ILE A 137
 None
 0.97A 4xv2A-5d5tA:
undetectable		 4xv2A-5d5tA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e0c CELLULASE

(Bacillus sp.
BG-CS10) 		PF00150
(Cellulase)
PF03442
(CBM_X2) 		4 GLY A 237
LEU A 274
PHE A 277
ILE A 284
 None
 0.96A 4xv2A-5e0cA:
undetectable		 4xv2A-5e0cA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fif CARBOXYLASE

(Deinococcus
radiodurans) 		PF01039
(Carboxyl_trans) 		4 GLY A 426
LEU A 366
PHE A 365
ILE A 343
 None
 0.81A 4xv2A-5fifA:
undetectable		 4xv2A-5fifA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lon KLLA0E01827P

(Kluyveromyces
lactis) 		PF06058
(DCP1) 		4 GLY B  52
LEU B  28
PHE B  15
ILE B  18
 None
 0.71A 4xv2A-5lonB:
undetectable		 4xv2A-5lonB:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkg DIGUANYLATE
PHOSPHODIESTERASE

(Pseudomonas
aeruginosa) 		PF00563
(EAL) 		4 GLY B  30
LEU B 200
PHE B 186
ILE B 182
 None
 0.83A 4xv2A-5mkgB:
undetectable		 4xv2A-5mkgB:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mvo FOXE

(Rhodobacter sp.
SW2) 		no annotation 4 GLY A  82
LEU A 248
PHE A 249
ILE A 107
 None
 0.78A 4xv2A-5mvoA:
undetectable		 4xv2A-5mvoA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nmp ISATIN HYDROLASE

(Ralstonia
solanacearum) 		no annotation 4 GLY A 191
LEU A 130
PHE A 129
ILE A 111
 None
 0.99A 4xv2A-5nmpA:
undetectable		 4xv2A-5nmpA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj1 DNA TOPOISOMERASE 1

(Mycobacterium
tuberculosis) 		no annotation 4 GLY A 338
LEU A 312
PHE A 307
ILE A 423
 None
 0.97A 4xv2A-5uj1A:
undetectable		 4xv2A-5uj1A:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x1y MERCURIC REDUCTASE

(Lysinibacillus
sphaericus) 		no annotation 4 GLY B 116
LEU B 354
PHE B 197
ILE B  90
 FAD  B 601 (-4.0A)
FAD  B 601 (-4.6A)
None
FAD  B 601 (-4.9A)
 0.83A 4xv2A-5x1yB:
undetectable		 4xv2A-5x1yB:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xb0 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Pseudomonas
syringae group
genomosp. 3) 		PF00254
(FKBP_C) 		4 GLY A  92
LEU A 151
PHE A 157
ILE A 207
 None
 0.89A 4xv2A-5xb0A:
undetectable		 4xv2A-5xb0A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ylv POTASSIUM-TRANSPORTI
NG ATPASE SUBUNIT
BETA

(Sus scrofa) 		no annotation 4 GLY B 171
LEU B 117
PHE B 116
ILE B 180
 None
 0.92A 4xv2A-5ylvB:
undetectable		 4xv2A-5ylvB:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aun PLA2G6, IPLA2BETA

(Cricetulus
griseus) 		no annotation 4 GLY A 532
LEU A 510
PHE A 509
ILE A 469
 None
 0.96A 4xv2A-6aunA:
undetectable		 4xv2A-6aunA:
14.63