SIMILAR PATTERNS OF AMINO ACIDS FOR 4XUM_A_IMNA502_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bs0 PROTEIN
(8-AMINO-7-OXONANOAT
E SYNTHASE)

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		4 ILE A  58
ARG A 284
LEU A  93
ILE A 283
 None
 0.98A 4xumA-1bs0A:
0.2		 4xumA-1bs0A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dcp DCOH

(Rattus
norvegicus) 		PF01329
(Pterin_4a) 		4 GLU A  97
ILE A  34
ARG A  88
ILE A  90
 None
 0.93A 4xumA-1dcpA:
undetectable		 4xumA-1dcpA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ddb PROTEIN (BID)

(Mus musculus) 		PF06393
(BID) 		4 GLU A  81
ILE A  16
LEU A 149
ILE A  86
 None
 0.92A 4xumA-1ddbA:
undetectable		 4xumA-1ddbA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ds9 OUTER ARM DYNEIN

(Chlamydomonas
reinhardtii) 		PF12799
(LRR_4) 		4 GLU A  61
ILE A  63
LEU A  98
ILE A  82
 None
 0.91A 4xumA-1ds9A:
0.0		 4xumA-1ds9A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e19 CARBAMATE KINASE

(Pyrococcus
furiosus) 		PF00696
(AA_kinase) 		5 GLU A 305
ILE A  40
ARG A   4
ILE A 230
MET A 232
 None
 1.47A 4xumA-1e19A:
0.0		 4xumA-1e19A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e69 CHROMOSOME
SEGREGATION SMC
PROTEIN

(Thermotoga
maritima) 		PF02463
(SMC_N) 		4 GLU A1105
ILE A  29
LEU A  82
ILE A  41
 None
 0.79A 4xumA-1e69A:
1.4		 4xumA-1e69A:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f7c RHOGAP PROTEIN

(Gallus gallus) 		PF00620
(RhoGAP) 		4 GLU A 370
ILE A 365
LEU A 261
MET A 316
 None
 0.87A 4xumA-1f7cA:
undetectable		 4xumA-1f7cA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flo FLP RECOMBINASE

(Saccharomyces
cerevisiae) 		PF03930
(Flp_N)
PF05202
(Flp_C) 		5 GLU A 410
ILE A 215
CYH A 217
LEU A 274
ILE A 407
 None
 1.10A 4xumA-1floA:
1.0		 4xumA-1floA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1foh PHENOL HYDROXYLASE

(Cutaneotrichosporon
cutaneum) 		PF01494
(FAD_binding_3)
PF07976
(Phe_hydrox_dim) 		4 GLU A 139
ILE A  12
LEU A  67
ILE A 128
 None
 0.94A 4xumA-1fohA:
0.0		 4xumA-1fohA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hu3 EIF4GII

(Homo sapiens) 		PF02854
(MIF4G) 		4 GLU A 844
ILE A 893
LEU A 940
ILE A 909
 None
 0.99A 4xumA-1hu3A:
0.0		 4xumA-1hu3A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i5n CHEMOTAXIS PROTEIN
CHEA

(Salmonella
enterica) 		PF01627
(Hpt) 		4 GLU A 117
ILE A  61
LEU A  20
ILE A  97
 None
 0.79A 4xumA-1i5nA:
undetectable		 4xumA-1i5nA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j5y TRANSCRIPTIONAL
REGULATOR, BIOTIN
REPRESSOR FAMILY

(Thermotoga
maritima) 		PF02829
(3H)
PF08279
(HTH_11) 		4 ILE A  98
ARG A  73
LEU A 171
ILE A 161
 None
 0.93A 4xumA-1j5yA:
undetectable		 4xumA-1j5yA:
25.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kk0 EIF2GAMMA

(Pyrococcus
abyssi) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF09173
(eIF2_C) 		4 GLU A  10
ILE A  57
LEU A  26
ILE A  13
 None
 0.94A 4xumA-1kk0A:
undetectable		 4xumA-1kk0A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nkq HYPOTHETICAL 28.8
KDA PROTEIN IN
PSD1-SKO1 INTERGENIC
REGION

(Saccharomyces
cerevisiae) 		PF01557
(FAA_hydrolase) 		4 GLU A  89
ILE A  12
LEU A  66
ILE A 150
 CA  A 260 ( 2.6A)
None
None
None
 0.89A 4xumA-1nkqA:
undetectable		 4xumA-1nkqA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nnh ASPARAGINYL-TRNA
SYNTHETASE-RELATED
PEPTIDE

(Pyrococcus
furiosus) 		PF00152
(tRNA-synt_2) 		4 ILE A  21
ARG A 267
LEU A 209
ILE A 263
 None
 0.93A 4xumA-1nnhA:
undetectable		 4xumA-1nnhA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o3u CONSERVED
HYPOTHETICAL PROTEIN
TM0613

(Thermotoga
maritima) 		PF05168
(HEPN) 		4 GLU A  67
ILE A 112
CYH A 116
ILE A  64
 None
 0.97A 4xumA-1o3uA:
undetectable		 4xumA-1o3uA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhm PYRUVATE
FORMATE-LYASE

(Escherichia
coli) 		PF02901
(PFL-like) 		4 GLU A1253
LEU A1053
ILE A1096
MET A1304
 None
 0.90A 4xumA-1qhmA:
undetectable		 4xumA-1qhmA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sbx SKI ONCOGENE

(Homo sapiens) 		PF02437
(Ski_Sno) 		4 GLU A 183
ILE A 177
LEU A 167
ILE A 110
 None
 0.96A 4xumA-1sbxA:
undetectable		 4xumA-1sbxA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sma MALTOGENIC AMYLASE

(Thermus sp.
IM6501) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		4 GLU A 223
CYH A 232
LEU A 185
ILE A 179
 None
 0.98A 4xumA-1smaA:
undetectable		 4xumA-1smaA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uli BIPHENYL DIOXYGENASE
LARGE SUBUNIT

(Rhodococcus
jostii) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		4 ILE A 329
CYH A 320
LEU A 178
MET A 188
 None
 0.83A 4xumA-1uliA:
undetectable		 4xumA-1uliA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbk HYPOTHETICAL PROTEIN
PH1313

(Pyrococcus
horikoshii) 		PF02568
(ThiI)
PF02926
(THUMP) 		4 GLU A  43
ARG A  50
ILE A  51
MET A  27
 None
 0.97A 4xumA-1vbkA:
undetectable		 4xumA-1vbkA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wvc GLUCOSE-1-PHOSPHATE
CYTIDYLYLTRANSFERASE

(Salmonella
enterica) 		PF00483
(NTP_transferase) 		4 GLU A 117
CYH A  55
LEU A  36
ILE A  52
 None
 0.92A 4xumA-1wvcA:
undetectable		 4xumA-1wvcA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2chg REPLICATION FACTOR C
SMALL SUBUNIT

(Archaeoglobus
fulgidus) 		PF00004
(AAA) 		4 GLU A  91
ILE A  89
ILE A  72
MET A  74
 None
 0.98A 4xumA-2chgA:
undetectable		 4xumA-2chgA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cqy PROPIONYL-COA
CARBOXYLASE ALPHA
CHAIN, MITOCHONDRIAL

(Homo sapiens) 		PF02786
(CPSase_L_D2) 		4 GLU A  93
ILE A  24
ARG A  42
ILE A  40
 None
 0.92A 4xumA-2cqyA:
undetectable		 4xumA-2cqyA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cvz 3-HYDROXYISOBUTYRATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		4 GLU A 194
ILE A 214
ARG A 206
ILE A 200
 None
 0.86A 4xumA-2cvzA:
undetectable		 4xumA-2cvzA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Thermus
thermophilus) 		PF00496
(SBP_bac_5) 		4 ILE A  36
ARG A 250
LEU A 258
ILE A  10
 None
 0.98A 4xumA-2d5wA:
undetectable		 4xumA-2d5wA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eff PROTEIN CYAY

(Escherichia
coli) 		PF01491
(Frataxin_Cyay) 		4 GLU A  92
ILE A  17
CYH A  32
ILE A  49
 None
 0.90A 4xumA-2effA:
undetectable		 4xumA-2effA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ex5 DNA ENDONUCLEASE
I-CEUI

(Chlamydomonas
moewusii) 		PF00961
(LAGLIDADG_1) 		4 GLU A  18
ARG A 112
LEU A 105
ILE A  23
 None
 0.88A 4xumA-2ex5A:
undetectable		 4xumA-2ex5A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmh ELECTRON TRANSFER
FLAVOPROTEIN-UBIQUIN
ONE OXIDOREDUCTASE

(Sus scrofa) 		PF05187
(ETF_QO)
PF13450
(NAD_binding_8) 		4 GLU A 335
ILE A 240
CYH A 556
ILE A 561
 None
None
SF4  A 610 (-2.2A)
None
 0.97A 4xumA-2gmhA:
undetectable		 4xumA-2gmhA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2il5 HYPOTHETICAL PROTEIN

(Staphylococcus
aureus) 		PF08327
(AHSA1) 		4 ILE A  91
ARG A  61
ILE A  62
MET A  41
 None
 0.96A 4xumA-2il5A:
undetectable		 4xumA-2il5A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k4y FEOA-LIKE PROTEIN

(Clostridium
acetobutylicum) 		PF04023
(FeoA) 		5 GLU A   9
ILE A  73
ARG A  66
LEU A  63
ILE A  54
 None
 1.21A 4xumA-2k4yA:
undetectable		 4xumA-2k4yA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lp4 CHEMOTAXIS PROTEIN
CHEA

(Escherichia
coli) 		PF01627
(Hpt)
PF09078
(CheY-binding) 		4 GLU A 117
ILE A  61
LEU A  20
ILE A  97
 None
 0.80A 4xumA-2lp4A:
undetectable		 4xumA-2lp4A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0q ALR1010 PROTEIN

(Nostoc sp. PCC
7120) 		PF11535
(Calci_bind_CcbP) 		4 GLU A  64
ILE A 103
LEU A 117
ILE A 100
 None
 0.95A 4xumA-2p0qA:
undetectable		 4xumA-2p0qA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qmm UPF0217 PROTEIN
AF_1056

(Archaeoglobus
fulgidus) 		PF04013
(Methyltrn_RNA_2) 		4 GLU A 164
ILE A 160
ARG A 139
ILE A 138
 None
 0.48A 4xumA-2qmmA:
undetectable		 4xumA-2qmmA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxq FAB

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ILE H  52
ARG H  98
LEU H   3
ILE H  28
 None
 0.85A 4xumA-2vxqH:
undetectable		 4xumA-2vxqH:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxy CELL DIVISION
PROTEIN FTSZ

(Bacillus
subtilis) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		4 GLU A  91
ILE A  89
ILE A  41
MET A  59
 None
 0.92A 4xumA-2vxyA:
undetectable		 4xumA-2vxyA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wm4 PUTATIVE CYTOCHROME
P450 124

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		4 GLU A 270
ILE A 190
ARG A 144
ILE A 176
 None
None
None
HEM  A 450 (-4.9A)
 0.95A 4xumA-2wm4A:
undetectable		 4xumA-2wm4A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wv9 FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT, FLAVIVIRIN
PROTEASE NS3
CATALYTIC SUBUNIT

(Murray Valley
encephalitis
virus) 		PF00271
(Helicase_C)
PF00949
(Peptidase_S7)
PF01002
(Flavi_NS2B)
PF07652
(Flavi_DEAD) 		4 GLU A 177
ILE A 313
LEU A 236
ILE A 204
 None
 0.87A 4xumA-2wv9A:
undetectable		 4xumA-2wv9A:
15.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 GLU A 259
ILE A 281
CYH A 285
ARG A 288
LEU A 330
ILE A 341
MET A 348
 None
MC5  A   1 ( 4.8A)
MC5  A   1 (-3.6A)
None
MC5  A   1 (-4.4A)
MC5  A   1 (-4.5A)
MC5  A   1 ( 4.0A)
 0.54A 4xumA-3b0qA:
41.1		 4xumA-3b0qA:
98.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxp PUTATIVE
LIPASE/ESTERASE

(Lactobacillus
plantarum) 		PF07859
(Abhydrolase_3) 		4 ILE A 151
LEU A  89
ILE A  39
MET A  37
 None
 0.98A 4xumA-3bxpA:
undetectable		 4xumA-3bxpA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cc8 PUTATIVE
METHYLTRANSFERASE

(Bacillus cereus) 		PF13489
(Methyltransf_23) 		4 GLU A 223
ILE A  28
LEU A  73
ILE A  97
 None
 0.99A 4xumA-3cc8A:
undetectable		 4xumA-3cc8A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddd PUTATIVE
ACETYLTRANSFERASE

(Pyrococcus
horikoshii) 		PF00583
(Acetyltransf_1) 		4 GLU A  54
ILE A  17
LEU A 114
ILE A  84
 None
None
COA  A 300 (-4.1A)
COA  A 300 ( 4.6A)
 0.87A 4xumA-3dddA:
undetectable		 4xumA-3dddA:
20.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		4 ILE D 281
LEU D 330
ILE D 341
MET D 348
 PLB  D 701 (-4.6A)
PLB  D 701 ( 4.1A)
PLB  D 701 (-3.6A)
PLB  D 701 ( 4.7A)
 0.49A 4xumA-3dzuD:
37.0		 4xumA-3dzuD:
91.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fsn RETINAL PIGMENT
EPITHELIUM-SPECIFIC
65 KDA PROTEIN

(Bos taurus) 		PF03055
(RPE65) 		4 GLU A 254
ILE A 202
LEU A 265
ILE A 259
 None
 0.98A 4xumA-3fsnA:
undetectable		 4xumA-3fsnA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gnn NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE

(Burkholderia
pseudomallei) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		5 GLU A 268
ILE A 266
ARG A 273
LEU A 230
MET A 239
 None
 1.13A 4xumA-3gnnA:
undetectable		 4xumA-3gnnA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzy BIPHENYL DIOXYGENASE
SUBUNIT ALPHA

(Comamonas
testosteroni) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		4 ILE A 337
CYH A 328
LEU A 187
MET A 197
 None
 0.85A 4xumA-3gzyA:
undetectable		 4xumA-3gzyA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5k RIBOSOME-INACTIVATIN
G PROTEIN
PD-L1/PD-L2

(Phytolacca
dioica) 		PF00161
(RIP) 		4 ILE A 210
LEU A  40
ILE A  37
MET A 248
 None
 0.98A 4xumA-3h5kA:
undetectable		 4xumA-3h5kA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjh TRANSCRIPTION-REPAIR
-COUPLING FACTOR

(Escherichia
coli) 		no annotation 4 GLU A 207
ILE A 189
LEU A 145
ILE A 209
 None
 0.98A 4xumA-3hjhA:
undetectable		 4xumA-3hjhA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hxl UNCHARACTERIZED
PROTEIN DSY3957

(Desulfitobacterium
hafniense) 		PF04984
(Phage_sheath_1)
PF17481
(Phage_sheath_1N)
PF17482
(Phage_sheath_1C) 		4 ILE A 353
ARG A 345
ILE A 396
MET A 387
 None
 0.99A 4xumA-3hxlA:
undetectable		 4xumA-3hxlA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igr RIBOSOMAL-PROTEIN-S5
-ALANINE
N-ACETYLTRANSFERASE

(Aliivibrio
fischeri) 		PF13302
(Acetyltransf_3) 		4 ILE A  89
ARG A 132
ILE A 133
MET A 124
 None
 0.93A 4xumA-3igrA:
undetectable		 4xumA-3igrA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jq0 SUSD SUPERFAMILY
PROTEIN

(Bacteroides
vulgatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 GLU A 222
ARG A 142
LEU A 158
ILE A 187
 None
 0.96A 4xumA-3jq0A:
undetectable		 4xumA-3jq0A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lfv CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF01590
(GAF) 		4 GLU A 348
CYH A 367
LEU A 492
ILE A 354
 None
 0.94A 4xumA-3lfvA:
undetectable		 4xumA-3lfvA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mlx HUMAN MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY 3074 FAB
HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ILE H  51
ARG H  94
LEU H   4
ILE H  29
 None
 0.87A 4xumA-3mlxH:
undetectable		 4xumA-3mlxH:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nqp SUSD SUPERFAMILY
PROTEIN

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 GLU A 233
ARG A 148
LEU A 164
ILE A 194
 None
 0.97A 4xumA-3nqpA:
undetectable		 4xumA-3nqpA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzp ARGININE
DECARBOXYLASE

(Campylobacter
jejuni) 		PF02784
(Orn_Arg_deC_N) 		4 GLU A 314
ILE A 306
LEU A 186
ILE A 269
 None
 0.96A 4xumA-3nzpA:
undetectable		 4xumA-3nzpA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oe7 ATP SYNTHASE SUBUNIT
GAMMA

(Saccharomyces
cerevisiae) 		PF00231
(ATP-synt) 		5 GLU G 229
ILE G 133
LEU G 150
ILE G  77
MET G 222
 None
 1.36A 4xumA-3oe7G:
undetectable		 4xumA-3oe7G:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3one ADENOSYLHOMOCYSTEINA
SE

(Lupinus luteus) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 GLU A 361
ILE A 355
ILE A 387
MET A 336
 None
 0.94A 4xumA-3oneA:
undetectable		 4xumA-3oneA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r38 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1

(Listeria
monocytogenes) 		PF00275
(EPSP_synthase) 		4 GLU A 276
ILE A 260
ILE A 252
MET A 240
 None
 0.79A 4xumA-3r38A:
undetectable		 4xumA-3r38A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9w GTPASE ERA

(Aquifex
aeolicus) 		PF01926
(MMR_HSR1)
PF07650
(KH_2) 		4 GLU A 140
ILE A  93
LEU A 165
ILE A 151
 None
 0.74A 4xumA-3r9wA:
undetectable		 4xumA-3r9wA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rf5 MACROPHAGE MIGRATION
INHIBITORY FACTOR

(Ancylostoma
ceylanicum) 		PF01187
(MIF) 		4 GLU A  62
ILE A  39
LEU A  87
ILE A  59
 None
 0.87A 4xumA-3rf5A:
undetectable		 4xumA-3rf5A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG

(Mus musculus) 		PF14631
(FancD2) 		5 GLU B 360
ILE B 352
ARG B 300
LEU B 303
ILE B 296
 None
 1.13A 4xumA-3s4wB:
undetectable		 4xumA-3s4wB:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sc6 DTDP-4-DEHYDRORHAMNO
SE REDUCTASE

(Bacillus
anthracis) 		PF04321
(RmlD_sub_bind) 		4 ILE A   7
CYH A  60
LEU A 153
ILE A 195
 None
None
NAP  A 285 (-4.5A)
None
 0.97A 4xumA-3sc6A:
undetectable		 4xumA-3sc6A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tje FAB E09, HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ILE H  53
ARG H 104
LEU H   4
ILE H  29
 None
 0.98A 4xumA-3tjeH:
undetectable		 4xumA-3tjeH:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9w LEUKOTRIENE A-4
HYDROLASE

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C) 		4 GLU A1296
ARG A1338
ILE A1328
MET A1240
 28P  A7001 (-2.6A)
None
None
None
 0.98A 4xumA-3u9wA:
undetectable		 4xumA-3u9wA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufg GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT

(Campylobacter
jejuni) 		PF02091
(tRNA-synt_2e) 		4 GLU A 229
ILE A 227
LEU A  40
ILE A 278
 None
 0.93A 4xumA-3ufgA:
undetectable		 4xumA-3ufgA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v67 SENSOR PROTEIN CPXA

(Vibrio
parahaemolyticus) 		PF16527
(CpxA_peri) 		4 GLU A  80
ILE A  75
ARG A  59
ILE A  62
 None
 0.98A 4xumA-3v67A:
undetectable		 4xumA-3v67A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vb9 UNCHARACTERIZED
PROTEIN VPA0735

(Vibrio
parahaemolyticus) 		PF06742
(DUF1214)
PF06863
(DUF1254) 		4 GLU A  72
ILE A 246
LEU A 335
ILE A  65
 None
 0.92A 4xumA-3vb9A:
undetectable		 4xumA-3vb9A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zi5 RESTRICTION
ENDONUCLEASE

(Bacillus firmus) 		no annotation 4 GLU A 313
ILE A 304
LEU A 241
ILE A 257
 None
 0.95A 4xumA-3zi5A:
undetectable		 4xumA-3zi5A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4art STRUCTURAL PROTEIN
ORF273

(Acidianus
two-tailed
virus) 		no annotation 4 GLU A  36
ILE A  67
LEU A 137
ILE A 141
 None
 0.96A 4xumA-4artA:
undetectable		 4xumA-4artA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4chh PROTEIN INTERACTING
WITH HSP90 1

(Saccharomyces
cerevisiae) 		PF08190
(PIH1) 		4 GLU A 137
ILE A  61
LEU A 171
ILE A  94
 None
 0.79A 4xumA-4chhA:
undetectable		 4xumA-4chhA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e6f UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF14730
(DUF4468) 		4 GLU A  43
ILE A 154
ARG A 139
ILE A 138
 None
None
EDO  A 403 ( 4.9A)
None
 0.96A 4xumA-4e6fA:
undetectable		 4xumA-4e6fA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4etq ANTI-VACCINIA D8L
ANTIGEN MURINE
MONOCLONAL IGG2A
ANTIBODY LA5, HEAVY
CHAIN

(Mus musculus) 		no annotation 4 GLU H  56
ILE H  52
ARG H  99
LEU H   5
 None
 0.97A 4xumA-4etqH:
undetectable		 4xumA-4etqH:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f92 U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		4 ILE B 586
CYH B 588
LEU B 631
ILE B 596
 None
 0.87A 4xumA-4f92B:
undetectable		 4xumA-4f92B:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgw GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(+)] 1

(Saccharomyces
cerevisiae) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		4 ILE A 168
ARG A 132
LEU A 111
ILE A 125
 None
 0.92A 4xumA-4fgwA:
undetectable		 4xumA-4fgwA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gt6 CELL SURFACE PROTEIN

(Faecalibacterium
prausnitzii) 		PF13306
(LRR_5) 		4 ILE A 305
LEU A 293
ILE A 275
MET A 298
 None
 0.88A 4xumA-4gt6A:
undetectable		 4xumA-4gt6A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6m ACTIN-RELATED
PROTEIN 7

(Saccharomyces
cerevisiae) 		PF00022
(Actin) 		4 GLU A 141
ILE A 393
LEU A 387
ILE A 169
 PO4  A 505 (-3.3A)
None
None
None
 0.92A 4xumA-4i6mA:
undetectable		 4xumA-4i6mA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE

(Saccharomyces
cerevisiae) 		PF03200
(Glyco_hydro_63)
PF16923
(Glyco_hydro_63N) 		4 GLU A 393
ILE A 430
ILE A 426
MET A 418
 None
 0.72A 4xumA-4j5tA:
undetectable		 4xumA-4j5tA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4je3 CENTRAL KINETOCHORE
SUBUNIT CHL4
CENTRAL KINETOCHORE
SUBUNIT IML3

(Saccharomyces
cerevisiae) 		PF05238
(CENP-N)
no annotation 		4 GLU A 171
ILE B 398
LEU B 402
ILE A 165
 None
 0.95A 4xumA-4je3A:
undetectable		 4xumA-4je3A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4js5 EXODEOXYRIBONUCLEASE
I

(Escherichia
coli) 		PF00929
(RNase_T)
PF08411
(Exonuc_X-T_C) 		4 GLU A 254
ILE A 350
ARG A 344
ILE A 260
 None
 0.86A 4xumA-4js5A:
undetectable		 4xumA-4js5A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4js5 EXODEOXYRIBONUCLEASE
I

(Escherichia
coli) 		PF00929
(RNase_T)
PF08411
(Exonuc_X-T_C) 		4 ILE A 350
ARG A 344
LEU A 337
ILE A 260
 None
 0.98A 4xumA-4js5A:
undetectable		 4xumA-4js5A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jwp GCN5-RELATED
N-ACETYLTRANSFERASE

(Brucella
abortus) 		PF13420
(Acetyltransf_4) 		4 GLU A  59
ILE A   5
LEU A 132
ILE A  98
 None
None
ACO  A 201 ( 4.2A)
ACO  A 201 (-4.4A)
 0.92A 4xumA-4jwpA:
undetectable		 4xumA-4jwpA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k2u ANTIBODY HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ILE H  51
ARG H  94
LEU H   4
ILE H  29
 None
SO4  H 301 (-2.8A)
None
None
 0.96A 4xumA-4k2uH:
undetectable		 4xumA-4k2uH:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k59 RNA BINDING PROTEIN
RSMF

(Pseudomonas
aeruginosa) 		PF02599
(CsrA) 		4 GLU A  56
ILE A  41
ARG A  65
ILE A  63
 None
 0.97A 4xumA-4k59A:
undetectable		 4xumA-4k59A:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ktd GE136 HEAVY CHAIN
FAB

(Macaca mulatta) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ILE H  51
ARG H  94
LEU H   4
ILE H  29
 None
 0.97A 4xumA-4ktdH:
undetectable		 4xumA-4ktdH:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l7t NANU SIALIC ACID
BINDING PROTEIN

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 GLU A 215
ARG A 135
LEU A 151
ILE A 180
 None
 0.96A 4xumA-4l7tA:
undetectable		 4xumA-4l7tA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m5y FAB 5J8 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ILE H  51
ARG H  94
LEU H   4
ILE H  29
 None
 0.90A 4xumA-4m5yH:
undetectable		 4xumA-4m5yH:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m88 EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Verminephrobacter
eiseniae) 		PF13458
(Peripla_BP_6) 		4 GLU A 283
ILE A 235
LEU A 184
ILE A 208
 GOL  A 403 (-2.9A)
None
None
None
 0.98A 4xumA-4m88A:
undetectable		 4xumA-4m88A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mbu SIMILAR TO
N-ACETYLTRANSFERASE

(Staphylococcus
aureus) 		PF13420
(Acetyltransf_4) 		4 GLU A  56
ILE A   2
LEU A 129
ILE A  95
 None
 0.84A 4xumA-4mbuA:
undetectable		 4xumA-4mbuA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mu9 GLYCOSIDE HYDROLASE
FAMILY 73

(Bacteroides
thetaiotaomicron) 		PF03663
(Glyco_hydro_76) 		4 GLU A 114
ILE A 146
LEU A 373
MET A  86
 None
 0.95A 4xumA-4mu9A:
undetectable		 4xumA-4mu9A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0l PREDICTED COMPONENT
OF A
THERMOPHILE-SPECIFIC
DNA REPAIR SYSTEM,
CONTAINS A RAMP
DOMAIN

(Methanopyrus
kandleri) 		PF03787
(RAMPs) 		4 GLU A 335
ILE A 272
LEU A  54
MET A 246
 None
 0.98A 4xumA-4n0lA:
undetectable		 4xumA-4n0lA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n9w GDP-MANNOSE-DEPENDEN
T
ALPHA-(1-2)-PHOSPHAT
IDYLINOSITOL
MANNOSYLTRANSFERASE

(Mycolicibacterium
smegmatis) 		PF13439
(Glyco_transf_4)
PF13692
(Glyco_trans_1_4) 		4 GLU A 361
ILE A 356
ARG A  29
ILE A   3
 None
 0.97A 4xumA-4n9wA:
undetectable		 4xumA-4n9wA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ook METHIONINE
AMINOPEPTIDASE 2

(Mycobacterium
tuberculosis) 		PF00557
(Peptidase_M24) 		4 GLU A 165
ILE A 187
LEU A 246
ILE A 241
 None
 0.98A 4xumA-4ookA:
undetectable		 4xumA-4ookA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p80 ANCESTRAL PYRR
PROTEIN (GREEN)

(synthetic
construct) 		PF00156
(Pribosyltran) 		4 GLU A  23
ILE A 101
ILE A  54
MET A  31
 None
 0.89A 4xumA-4p80A:
undetectable		 4xumA-4p80A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxb UREIDOGLYCOLATE
HYDROLASE

(Arabidopsis
thaliana) 		PF01546
(Peptidase_M20) 		4 GLU A 176
ILE A 119
LEU A  73
MET A 104
 None
 0.99A 4xumA-4pxbA:
undetectable		 4xumA-4pxbA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qgk FATTY ALDEHYDE
DEHYDROGENASE

(Homo sapiens) 		PF00171
(Aldedh) 		4 GLU A 250
ILE A 216
CYH A 214
ILE A 339
 None
 0.95A 4xumA-4qgkA:
undetectable		 4xumA-4qgkA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qvh MALTOSE-BINDING
PERIPLASMIC PROTEIN,
4'-PHOSPHOPANTETHEIN
YL TRANSFERASE
CHIMERA

(Escherichia
coli;
Mycobacterium
tuberculosis) 		PF01648
(ACPS)
PF13416
(SBP_bac_8) 		4 GLU A 552
ILE A 549
LEU A 492
ILE A 522
 None
 0.84A 4xumA-4qvhA:
undetectable		 4xumA-4qvhA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5d LEUCINE RICH REPEAT
PROTEIN

(synthetic
construct) 		PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 GLU A 300
ILE A 325
LEU A 344
ILE A 305
 None
 0.85A 4xumA-4r5dA:
undetectable		 4xumA-4r5dA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6g LEUCINE RICH REPEATS
DLRR_K

(synthetic
construct) 		PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 GLU A 380
ILE A 405
LEU A 424
ILE A 385
 None
 0.84A 4xumA-4r6gA:
undetectable		 4xumA-4r6gA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u4i CU/ZN SUPEROXIDE
DISMUTASE

(Megavirus
chiliensis) 		PF00080
(Sod_Cu) 		4 ILE A  55
CYH A  53
LEU A  43
ILE A  39
 None
 0.85A 4xumA-4u4iA:
undetectable		 4xumA-4u4iA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xb6 ALPHA-D-RIBOSE
1-METHYLPHOSPHONATE
5-PHOSPHATE C-P
LYASE
ALPHA-D-RIBOSE
1-METHYLPHOSPHONATE
5-TRIPHOSPHATE
SYNTHASE SUBUNIT
PHNH

(Escherichia
coli) 		PF05845
(PhnH)
PF06007
(PhnJ) 		4 GLU B 118
ILE D 213
ARG D  40
LEU D  12
 None
 0.85A 4xumA-4xb6B:
undetectable		 4xumA-4xb6B:
22.14