SIMILAR PATTERNS OF AMINO ACIDS FOR 4XUM_A_IMNA501_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE

(Escherichia
coli) 		PF00982
(Glyco_transf_20) 		5 PHE A  79
ILE A 155
LEU A 166
LEU A 172
LEU A 134
 None
G6P  A 901 (-4.8A)
None
None
None
 1.22A 4xumA-1gz5A:
undetectable		 4xumA-1gz5A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jeq KU70

(Homo sapiens) 		PF02037
(SAP)
PF02735
(Ku)
PF03730
(Ku_C)
PF03731
(Ku_N) 		5 SER A 257
LEU A 434
LEU A 345
LEU A 259
TYR A 400
 None
 1.28A 4xumA-1jeqA:
undetectable		 4xumA-1jeqA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k0f PERIPLASMIC
ZINC-BINDING PROTEIN
TROA

(Treponema
pallidum) 		PF01297
(ZnuA) 		5 SER A 250
HIS A 199
ILE A 251
HIS A  68
LEU A  93
 None
 1.24A 4xumA-1k0fA:
0.0		 4xumA-1k0fA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qe0 HISTIDINE--TRNA
LIGASE

(Staphylococcus
aureus) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		6 PHE A 127
SER A 153
HIS A 149
PHE A 306
LEU A  29
TYR A  33
 None
 1.43A 4xumA-1qe0A:
0.0		 4xumA-1qe0A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r88 MPT51/MPB51 ANTIGEN

(Mycobacterium
tuberculosis) 		PF00756
(Esterase) 		5 SER A 103
PHE A 119
MET A  46
LEU A 120
LEU A  65
 None
 1.32A 4xumA-1r88A:
undetectable		 4xumA-1r88A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v27 REGULATING SYNAPTIC
MEMBRANE EXOCYTOSIS
PROTEIN 2

(Homo sapiens) 		PF00168
(C2) 		5 ILE A  27
PHE A  50
LEU A  23
LEU A 122
LEU A  14
 None
 1.28A 4xumA-1v27A:
undetectable		 4xumA-1v27A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjv UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 6

(Saccharomyces
cerevisiae) 		PF00443
(UCH) 		5 PHE A 233
ILE A 160
PHE A 214
LEU A 127
LEU A 133
 None
 1.25A 4xumA-1vjvA:
0.0		 4xumA-1vjvA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xc6 BETA-GALACTOSIDASE

(Penicillium sp.) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		5 PHE A 913
LEU A 956
LEU A 901
LEU A 903
TYR A 958
 None
 1.21A 4xumA-1xc6A:
undetectable		 4xumA-1xc6A:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zg4 BETA-LACTAMASE TEM

(Escherichia
coli) 		PF13354
(Beta-lactamase2) 		5 PHE A 151
ILE A 127
LEU A 193
LEU A 199
LEU A  81
 None
 1.30A 4xumA-1zg4A:
0.0		 4xumA-1zg4A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a5z HYPOTHETICAL PROTEIN
SO2946

(Shewanella
oneidensis) 		no annotation 5 PHE A 124
LEU A 179
LEU A 201
LEU A 209
TYR A 177
 None
 1.28A 4xumA-2a5zA:
undetectable		 4xumA-2a5zA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Sulfolobus
solfataricus) 		PF00348
(polyprenyl_synt) 		5 ILE A 251
PHE A  51
LEU A 264
LEU A 192
TYR A 244
 None
 1.28A 4xumA-2azkA:
1.9		 4xumA-2azkA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bex RIBONUCLEASE
INHIBITOR

(Homo sapiens) 		PF13516
(LRR_6) 		5 CYH A 247
ILE A 267
LEU A 279
LEU A 285
LEU A 260
 None
 1.22A 4xumA-2bexA:
undetectable		 4xumA-2bexA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bnh RIBONUCLEASE
INHIBITOR

(Sus scrofa) 		PF13516
(LRR_6) 		5 CYH A 243
ILE A 263
LEU A 275
LEU A 281
LEU A 256
 None
 1.32A 4xumA-2bnhA:
undetectable		 4xumA-2bnhA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dyl DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		5 PHE A 372
ILE A 273
PHE A 369
LEU A 328
LEU A 324
 None
 1.26A 4xumA-2dylA:
undetectable		 4xumA-2dylA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f1z UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7

(Homo sapiens) 		PF00443
(UCH)
PF00917
(MATH) 		5 ILE A 494
LEU A 431
LEU A 404
LEU A 516
TYR A 518
 None
 1.21A 4xumA-2f1zA:
undetectable		 4xumA-2f1zA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1i RIBONUCLEOTIDE
REDUCTASE, SMALL
CHAIN

(Plasmodium
yoelii) 		PF00268
(Ribonuc_red_sm) 		5 SER A 218
PHE A 206
LEU A  92
LEU A 140
TYR A 144
 None
 1.19A 4xumA-2p1iA:
undetectable		 4xumA-2p1iA:
23.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 PHE A 273
CYH A 276
SER A 280
ILE A 317
MET A 355
HIS A 440
LEU A 456
LEU A 460
TYR A 464
 735  A 469 (-3.7A)
735  A 469 (-2.9A)
735  A 469 (-2.8A)
735  A 469 ( 4.8A)
735  A 469 (-2.9A)
735  A 469 (-4.0A)
735  A 469 ( 4.8A)
735  A 469 (-4.3A)
735  A 469 (-4.6A)
 0.69A 4xumA-2p54A:
37.3		 4xumA-2p54A:
61.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qv5 UNCHARACTERIZED
PROTEIN ATU2773

(Agrobacterium
fabrum) 		PF04748
(Polysacc_deac_2) 		5 PHE A 303
ILE A 258
LEU A 289
LEU A 233
LEU A 248
 None
 1.31A 4xumA-2qv5A:
undetectable		 4xumA-2qv5A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpw THIOSULFATE
REDUCTASE

(Thermus
thermophilus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 ILE A 440
LEU A 456
LEU A 459
LEU A 435
TYR A 462
 MGD  A1765 (-4.3A)
None
None
None
None
 1.15A 4xumA-2vpwA:
undetectable		 4xumA-2vpwA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z01 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Geobacillus
kaustophilus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 PHE A 199
ILE A 278
LEU A  70
LEU A 206
LEU A 217
 None
 1.00A 4xumA-2z01A:
undetectable		 4xumA-2z01A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7x TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		5 PHE A 120
ILE A 181
LEU A 115
LEU A 139
TYR A 136
 None
 1.16A 4xumA-2z7xA:
undetectable		 4xumA-2z7xA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z80 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		5 PHE A 120
ILE A 181
LEU A 115
LEU A 139
TYR A 136
 None
 1.10A 4xumA-2z80A:
undetectable		 4xumA-2z80A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Mus musculus) 		PF11921
(DUF3439)
PF13306
(LRR_5)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 PHE A 120
ILE A 181
LEU A 115
LEU A 139
TYR A 136
 None
 1.10A 4xumA-2z81A:
undetectable		 4xumA-2z81A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zhy ATP:COB(I)ALAMIN
ADENOSYLTRANSFERASE,
PUTATIVE

(Burkholderia
thailandensis) 		PF01923
(Cob_adeno_trans) 		5 CYH A 124
ILE A  65
LEU A  54
LEU A 166
LEU A 162
 None
 1.18A 4xumA-2zhyA:
undetectable		 4xumA-2zhyA:
20.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 CYH A 285
SER A 289
HIS A 323
ILE A 326
MET A 364
HIS A 449
LEU A 453
LEU A 465
LEU A 469
TYR A 473
 MC5  A   1 (-3.6A)
MC5  A   1 (-2.6A)
MC5  A   1 (-3.8A)
MC5  A   1 ( 4.9A)
MC5  A   1 (-3.7A)
MC5  A   1 (-3.9A)
MC5  A   1 (-4.2A)
None
MC5  A   1 (-4.1A)
MC5  A   1 (-4.9A)
 0.70A 4xumA-3b0qA:
41.1		 4xumA-3b0qA:
98.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 HIS A 323
ILE A 326
PHE A 282
LEU A 453
TYR A 473
 MC5  A   1 (-3.8A)
MC5  A   1 ( 4.9A)
MC5  A   1 (-4.4A)
MC5  A   1 (-4.2A)
MC5  A   1 (-4.9A)
 1.09A 4xumA-3b0qA:
41.1		 4xumA-3b0qA:
98.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 PHE A 282
CYH A 285
SER A 289
HIS A 323
LEU A 469
 MC5  A   1 (-4.4A)
MC5  A   1 (-3.6A)
MC5  A   1 (-2.6A)
MC5  A   1 (-3.8A)
MC5  A   1 (-4.1A)
 0.94A 4xumA-3b0qA:
41.1		 4xumA-3b0qA:
98.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d5f PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 PHE A 282
CYH A 285
HIS A 323
ILE A 326
HIS A 449
LEU A 465
LEU A 469
TYR A 473
 L41  A 501 ( 4.9A)
L41  A 501 (-3.5A)
L41  A 501 (-3.8A)
None
L41  A 501 (-3.9A)
None
L41  A 501 (-3.8A)
L41  A 501 (-4.8A)
 0.85A 4xumA-3d5fA:
36.2		 4xumA-3d5fA:
62.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dw8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
55 KDA REGULATORY
SUBUNIT B ALPHA
ISOFORM

(Homo sapiens) 		no annotation 5 HIS B 326
LEU B 306
LEU B 333
LEU B 336
TYR B 305
 None
 1.29A 4xumA-3dw8B:
undetectable		 4xumA-3dw8B:
20.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		5 PHE D 282
ILE D 326
MET D 364
HIS D 449
LEU D 469
 None
PLB  D 701 ( 4.5A)
PLB  D 701 ( 4.8A)
None
None
 1.02A 4xumA-3dzuD:
37.0		 4xumA-3dzuD:
91.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		5 PHE D 282
ILE D 326
PHE D 363
MET D 364
LEU D 469
 None
PLB  D 701 ( 4.5A)
None
PLB  D 701 ( 4.8A)
None
 1.16A 4xumA-3dzuD:
37.0		 4xumA-3dzuD:
91.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		5 PHE D 282
PHE D 363
MET D 364
LEU D 465
LEU D 469
 None
None
PLB  D 701 ( 4.8A)
None
None
 1.24A 4xumA-3dzuD:
37.0		 4xumA-3dzuD:
91.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		6 SER D 289
ILE D 326
MET D 364
HIS D 449
LEU D 469
TYR D 473
 PLB  D 701 ( 3.9A)
PLB  D 701 ( 4.5A)
PLB  D 701 ( 4.8A)
None
None
None
 0.84A 4xumA-3dzuD:
37.0		 4xumA-3dzuD:
91.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		6 SER D 289
ILE D 326
PHE D 363
MET D 364
LEU D 469
TYR D 473
 PLB  D 701 ( 3.9A)
PLB  D 701 ( 4.5A)
None
PLB  D 701 ( 4.8A)
None
None
 0.65A 4xumA-3dzuD:
37.0		 4xumA-3dzuD:
91.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		6 SER D 289
PHE D 363
MET D 364
LEU D 465
LEU D 469
TYR D 473
 PLB  D 701 ( 3.9A)
None
PLB  D 701 ( 4.8A)
None
None
None
 0.71A 4xumA-3dzuD:
37.0		 4xumA-3dzuD:
91.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eh1 PROTEIN TRANSPORT
PROTEIN SEC24B

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		5 PHE A 865
ILE A 718
LEU A 699
LEU A 910
LEU A 914
 None
 1.30A 4xumA-3eh1A:
undetectable		 4xumA-3eh1A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3flo DNA POLYMERASE ALPHA
SUBUNIT B

(Saccharomyces
cerevisiae) 		PF04042
(DNA_pol_E_B)
PF08418
(Pol_alpha_B_N) 		5 PHE A 465
ILE A 417
PHE A 435
LEU A 484
LEU A 510
 None
 1.17A 4xumA-3floA:
undetectable		 4xumA-3floA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9o INTRACELLULAR GROWTH
LOCUS PROTEIN A
INTRACELLULAR GROWTH
LOCUS PROTEIN B

(Francisella
tularensis) 		PF05591
(T6SS_VipA)
PF05943
(VipB) 		5 PHE B 146
SER B 153
PHE A  50
LEU B 123
LEU A  33
 None
 1.14A 4xumA-3j9oB:
undetectable		 4xumA-3j9oB:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN

(Escherichia
coli) 		PF00580
(UvrD-helicase)
PF12705
(PDDEXK_1)
PF13361
(UvrD_C) 		5 PHE B 461
ILE B 857
LEU B 806
LEU B 802
LEU B 838
 None
 1.13A 4xumA-3k70B:
undetectable		 4xumA-3k70B:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2h PUTATIVE SUGAR
PHOSPHATE ISOMERASE

(Acidithiobacillus
ferrooxidans) 		PF07883
(Cupin_2) 		5 HIS A  23
LEU A  25
LEU A 146
LEU A 137
TYR A 130
 None
 1.13A 4xumA-3l2hA:
undetectable		 4xumA-3l2hA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m19 VARIABLE LYMPHOCYTE
RECEPTOR A DIVERSITY
REGION

(Petromyzon
marinus) 		PF13855
(LRR_8) 		5 PHE A  78
ILE A  32
LEU A  49
LEU A  65
LEU A  41
 None
 1.23A 4xumA-3m19A:
undetectable		 4xumA-3m19A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogr BETA-GALACTOSIDASE

(Trichoderma
reesei) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		5 PHE A 926
LEU A 968
LEU A 913
LEU A 915
TYR A 970
 None
 1.17A 4xumA-3ogrA:
undetectable		 4xumA-3ogrA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3red HYDROXYNITRILE LYASE

(Prunus mume) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 ILE A 145
PHE A   9
HIS A   7
LEU A  67
LEU A  66
 None
 1.26A 4xumA-3redA:
undetectable		 4xumA-3redA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5t DUF3298 FAMILY
PROTEIN

(Bacteroides
fragilis) 		PF11738
(DUF3298)
PF13739
(DUF4163) 		5 SER A  67
PHE A  80
LEU A 152
LEU A 178
TYR A 147
 None
 1.29A 4xumA-3s5tA:
undetectable		 4xumA-3s5tA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s9v ABIETADIENE
SYNTHASE,
CHLOROPLASTIC

(Abies grandis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 PHE A 662
LEU A 693
LEU A 620
LEU A 623
TYR A 624
 None
 1.25A 4xumA-3s9vA:
undetectable		 4xumA-3s9vA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3twi VARIABLE LYMPHOCYTE
RECEPTOR B

(Petromyzon
marinus) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		5 PHE D  93
ILE D  47
LEU D  64
LEU D  80
LEU D  56
 None
GOL  D   2 (-3.5A)
None
None
None
 1.24A 4xumA-3twiD:
undetectable		 4xumA-3twiD:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfo POLY A POLYMERASE

(Aquifex
aeolicus) 		PF01743
(PolyA_pol)
PF01966
(HD)
PF12627
(PolyA_pol_RNAbd) 		5 ILE A 436
PHE A 303
LEU A 318
LEU A 373
LEU A 411
 None
 1.29A 4xumA-3wfoA:
undetectable		 4xumA-3wfoA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wmd PROBABLE MONENSIN
BIOSYNTHESIS
ISOMERASE

(Streptomyces
cinnamonensis) 		PF12680
(SnoaL_2) 		5 HIS A  13
ILE A  17
LEU A  35
LEU A  50
TYR A  29
 None
 1.31A 4xumA-3wmdA:
undetectable		 4xumA-3wmdA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4az3 LYSOSOMAL PROTECTIVE
PROTEIN 20 KDA CHAIN
LYSOSOMAL PROTECTIVE
PROTEIN 32 KDA CHAIN

(Homo sapiens) 		PF00450
(Peptidase_S10) 		5 ILE A   7
PHE A 106
LEU B 313
LEU A  67
TYR B 312
 None
 1.28A 4xumA-4az3A:
undetectable		 4xumA-4az3A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4az3 LYSOSOMAL PROTECTIVE
PROTEIN 20 KDA CHAIN
LYSOSOMAL PROTECTIVE
PROTEIN 32 KDA CHAIN

(Homo sapiens) 		PF00450
(Peptidase_S10) 		5 PHE A  73
HIS A  35
ILE B 324
LEU A  66
LEU A  63
 None
 1.31A 4xumA-4az3A:
undetectable		 4xumA-4az3A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cyf PANTETHEINASE

(Homo sapiens) 		PF00795
(CN_hydrolase) 		5 PHE A 250
HIS A 387
LEU A 215
LEU A 395
TYR A 393
 None
 1.32A 4xumA-4cyfA:
undetectable		 4xumA-4cyfA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cyj PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3-LIKE PROTEIN

(Chaetomium
thermophilum) 		no annotation 5 PHE A 567
LEU A 535
LEU A 590
LEU A 616
TYR A 620
 None
 1.14A 4xumA-4cyjA:
undetectable		 4xumA-4cyjA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d0k PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3-LIKE PROTEIN

(Chaetomium
thermophilum) 		no annotation 5 PHE B 493
LEU B 461
LEU B 516
LEU B 542
TYR B 546
 None
 1.17A 4xumA-4d0kB:
undetectable		 4xumA-4d0kB:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g6b CITRATE SYNTHASE

(Escherichia
coli) 		PF00285
(Citrate_synt) 		5 PHE A 103
ILE A 224
LEU A 165
LEU A  90
LEU A  89
 None
 1.31A 4xumA-4g6bA:
undetectable		 4xumA-4g6bA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iug BETA-GALACTOSIDASE A

(Aspergillus
oryzae) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		5 PHE A 910
LEU A 950
LEU A 898
LEU A 900
TYR A 952
 None
 1.24A 4xumA-4iugA:
undetectable		 4xumA-4iugA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0k TANNASE

(Lactobacillus
plantarum) 		no annotation 5 HIS A 207
ILE A 426
LEU A 434
LEU A 400
LEU A 397
 None
 1.26A 4xumA-4j0kA:
undetectable		 4xumA-4j0kA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j34 KYNURENINE
3-MONOOXYGENASE

(Saccharomyces
cerevisiae) 		PF01494
(FAD_binding_3) 		5 PHE A 286
SER A 243
ILE A 200
LEU A 266
LEU A 231
 None
 1.11A 4xumA-4j34A:
undetectable		 4xumA-4j34A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k5u VARIABLE LYMPHOCYTE
RECEPTOR

(Petromyzon
marinus) 		no annotation 5 PHE B  74
ILE B  28
LEU B  45
LEU B  61
LEU B  37
 None
 1.32A 4xumA-4k5uB:
undetectable		 4xumA-4k5uB:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lar SINGLE HEAVY CHAIN
VARIABLE FRAGMENT
SINGLE LIGHT CHAIN
VARIABLE FRAGMENT

(Mus musculus) 		PF07686
(V-set) 		5 SER H  93
ILE H  37
HIS L  89
LEU L  46
TYR L  36
 None
None
1WE  L 300 (-4.2A)
None
None
 1.30A 4xumA-4larH:
undetectable		 4xumA-4larH:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mwt LYSOSOMAL PROTECTIVE
PROTEIN

(Homo sapiens) 		PF00450
(Peptidase_S10) 		5 ILE A   7
PHE A 106
LEU A 313
LEU A  67
TYR A 312
 ILE  A   7 ( 0.7A)
PHE  A 106 ( 1.3A)
LEU  A 313 ( 0.6A)
LEU  A  67 ( 0.5A)
TYR  A 312 ( 1.3A)
 1.26A 4xumA-4mwtA:
undetectable		 4xumA-4mwtA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p37 PUTATIVE POLY(A)
POLYMERASE CATALYTIC
SUBUNIT

(Megavirus
chiliensis) 		no annotation 5 HIS B 169
LEU B 172
LEU B 176
LEU B 369
TYR B 373
 None
None
None
None
PEG  B 602 ( 4.5A)
 1.11A 4xumA-4p37B:
undetectable		 4xumA-4p37B:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txa ROQUIN-1

(Mus musculus) 		PF13445
(zf-RING_UBOX) 		5 HIS A 389
LEU A 129
LEU A 137
LEU A 106
TYR A 109
 None
 1.13A 4xumA-4txaA:
undetectable		 4xumA-4txaA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ufs LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5

(Homo sapiens) 		PF00560
(LRR_1)
PF01462
(LRRNT)
PF13855
(LRR_8) 		5 ILE A 460
PHE A 418
LEU A 429
LEU A 434
LEU A 456
 None
 1.21A 4xumA-4ufsA:
undetectable		 4xumA-4ufsA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uyi STRUCTURE-SPECIFIC
ENDONUCLEASE SUBUNIT
SLX4

(Homo sapiens) 		PF00651
(BTB) 		5 PHE A 695
SER A 691
LEU A 752
LEU A 710
TYR A 756
 None
 1.21A 4xumA-4uyiA:
undetectable		 4xumA-4uyiA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9v PARTICLE-ASSOCIATED
LYASE

(Acinetobacter
virus AP22) 		no annotation 5 ILE A 311
PHE A 362
LEU A 356
LEU A 354
LEU A 331
 EDO  A 803 (-4.6A)
None
None
None
None
 1.32A 4xumA-4y9vA:
undetectable		 4xumA-4y9vA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zou STRUCTURE-SPECIFIC
ENDONUCLEASE SUBUNIT
SLX4

(Homo sapiens) 		PF00651
(BTB) 		5 PHE A 695
SER A 691
LEU A 752
LEU A 710
TYR A 756
 None
 1.24A 4xumA-4zouA:
undetectable		 4xumA-4zouA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aqa OFF7_DB04V3

(synthetic
construct) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13354
(Beta-lactamase2) 		5 PHE A 281
ILE A 257
LEU A 323
LEU A 329
LEU A 211
 None
 1.29A 4xumA-5aqaA:
undetectable		 4xumA-5aqaA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c77 PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1

(Saccharomyces
cerevisiae) 		PF04252
(RNA_Me_trans) 		5 HIS A   7
LEU A  34
LEU A  55
LEU A  50
TYR A  20
 None
 1.32A 4xumA-5c77A:
undetectable		 4xumA-5c77A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF

(Serratia sp.
FS14) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 PHE A 303
PHE A 248
LEU A 380
LEU A 262
LEU A 259
 None
 1.28A 4xumA-5cioA:
undetectable		 4xumA-5cioA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus musculus) 		PF08696
(Dna2)
PF13086
(AAA_11)
PF13087
(AAA_12) 		5 CYH A 773
ILE A 747
PHE A 783
LEU A 592
LEU A 582
 None
 1.19A 4xumA-5eawA:
undetectable		 4xumA-5eawA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus musculus) 		PF08696
(Dna2)
PF13086
(AAA_11)
PF13087
(AAA_12) 		5 PHE A 983
ILE A 834
PHE A 895
LEU A1031
LEU A1002
 None
 1.19A 4xumA-5eawA:
undetectable		 4xumA-5eawA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fgl NICR

(Pseudomonas
putida) 		PF00440
(TetR_N) 		5 PHE A  76
LEU A 138
LEU A 149
LEU A 153
TYR A 154
 None
None
None
None
6HY  A 301 (-3.4A)
 1.23A 4xumA-5fglA:
2.3		 4xumA-5fglA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmg PROTEASOME SUBUNIT
BETA TYPE

(Plasmodium
falciparum) 		PF00227
(Proteasome) 		5 SER M  82
HIS M  93
ILE M  89
LEU M 120
LEU M 138
 None
 1.02A 4xumA-5fmgM:
undetectable		 4xumA-5fmgM:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 PHE A 168
ILE A 115
LEU A 178
LEU A 176
LEU A 152
 None
 1.14A 4xumA-5gr8A:
undetectable		 4xumA-5gr8A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdh TOLL-LIKE RECEPTOR 8

(Homo sapiens) 		PF13855
(LRR_8) 		5 PHE A 579
ILE A 496
LEU A 561
LEU A 559
LEU A 535
 None
 1.24A 4xumA-5hdhA:
undetectable		 4xumA-5hdhA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2g DIOL DEHYDRATASE

(Roseburia
inulinivorans) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		5 PHE A 492
ILE A 650
PHE A 489
LEU A 565
LEU A 462
 None
 1.29A 4xumA-5i2gA:
undetectable		 4xumA-5i2gA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijb TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA

(Eptatretus
burgeri;
Mus musculus) 		PF00560
(LRR_1)
PF11921
(DUF3439)
PF13855
(LRR_8) 		5 PHE A 514
ILE A 464
LEU A 501
LEU A 499
LEU A 474
 None
 1.22A 4xumA-5ijbA:
undetectable		 4xumA-5ijbA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5im6 DESIGNED
SELF-ASSEMBLING
ICOSAHEDRAL CAGE
I32-28 TRIMERIC
SUBUNIT

(Burkholderia
thailandensis) 		PF01923
(Cob_adeno_trans) 		5 CYH A 124
ILE A  65
LEU A  54
LEU A 166
LEU A 162
 None
 1.20A 4xumA-5im6A:
undetectable		 4xumA-5im6A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6q CELL WALL BINDING
PROTEIN CWP8

(Clostridioides
difficile) 		PF04122
(CW_binding_2) 		5 PHE A 249
PHE A 225
LEU A 280
LEU A 276
LEU A 200
 None
 1.19A 4xumA-5j6qA:
undetectable		 4xumA-5j6qA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jtv UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7

(Homo sapiens) 		PF00443
(UCH)
PF14533
(USP7_C2) 		5 ILE A 494
LEU A 431
LEU A 404
LEU A 516
TYR A 518
 None
 1.24A 4xumA-5jtvA:
undetectable		 4xumA-5jtvA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzs PUTATIVE CELL
SURFACE PROTEIN,
SIMILAR TO
INTERNALIN PROTEINS

(Listeria
monocytogenes) 		PF12354
(Internalin_N)
PF13855
(LRR_8) 		5 PHE A 238
ILE A 166
LEU A 226
LEU A 224
LEU A 202
 None
 1.14A 4xumA-5kzsA:
undetectable		 4xumA-5kzsA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5med ARACHIDONATE
15-LIPOXYGENASE

(Cyanothece sp.
PCC 8801) 		PF00305
(Lipoxygenase) 		5 HIS A 280
LEU A 404
LEU A 434
LEU A 388
TYR A 392
 None
 1.25A 4xumA-5medA:
undetectable		 4xumA-5medA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nv3 RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN

(Rhodobacter
sphaeroides) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 PHE A 312
ILE A 123
LEU A 271
LEU A 319
TYR A 275
 None
 0.96A 4xumA-5nv3A:
undetectable		 4xumA-5nv3A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojq HAEMOLYSIN
CO-REGULATED PROTEIN

(Vibrio cholerae) 		PF05638
(T6SS_HCP) 		5 HIS 1  65
PHE 1  44
HIS 1  46
LEU 1 115
TYR 1 148
 None
 1.30A 4xumA-5ojq1:
undetectable		 4xumA-5ojq1:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5svd NUCLEOLAR PROTEIN 9

(Saccharomyces
cerevisiae) 		PF00806
(PUF) 		5 SER A 488
HIS A 523
LEU A 472
LEU A 467
LEU A 465
 SER  A 488 ( 0.0A)
HIS  A 523 ( 1.0A)
LEU  A 472 ( 0.5A)
LEU  A 467 ( 0.6A)
LEU  A 465 ( 0.5A)
 1.31A 4xumA-5svdA:
undetectable		 4xumA-5svdA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tf2 PROLACTIN REGULATORY
ELEMENT-BINDING
PROTEIN

(Homo sapiens) 		PF00400
(WD40) 		5 SER A  64
ILE A  41
LEU A  48
LEU A  61
TYR A  10
 None
 1.32A 4xumA-5tf2A:
undetectable		 4xumA-5tf2A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uf1 O13

(Petromyzon
marinus) 		no annotation 5 PHE B  93
ILE B  47
LEU B  64
LEU B  80
LEU B  56
 None
 1.31A 4xumA-5uf1B:
undetectable		 4xumA-5uf1B:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ufb TN4-22

(Petromyzon
marinus) 		no annotation 5 PHE A  76
ILE A  30
LEU A  47
LEU A  63
LEU A  39
 None
 1.28A 4xumA-5ufbA:
undetectable		 4xumA-5ufbA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uff RBC36

(Petromyzon
marinus) 		no annotation 5 PHE A  93
ILE A  47
LEU A  64
LEU A  80
LEU A  56
 None
 1.32A 4xumA-5uffA:
undetectable		 4xumA-5uffA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5veu CYTOCHROME P450 3A5

(Homo sapiens) 		no annotation 5 PHE A 316
HIS A 403
LEU A 476
LEU A 482
TYR A 399
 None
 1.32A 4xumA-5veuA:
2.0		 4xumA-5veuA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vni PROTEIN TRANSPORT
PROTEIN SEC23A

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		5 PHE A 580
MET A 581
LEU A 616
LEU A 612
LEU A  41
 None
 1.31A 4xumA-5vniA:
undetectable		 4xumA-5vniA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wln TYPE II SECRETION
SYSTEM PROTEIN D

(Pseudomonas
aeruginosa) 		no annotation 5 SER G 268
ILE G 267
LEU G 301
LEU G 303
LEU G 313
 None
 1.07A 4xumA-5wlnG:
undetectable		 4xumA-5wlnG:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wvc CASPASE

(Homo sapiens) 		no annotation 5 PHE D 273
CYH D 276
PHE D 235
LEU D 258
LEU D 220
 None
 1.26A 4xumA-5wvcD:
undetectable		 4xumA-5wvcD:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wve CASPASE

(Homo sapiens) 		PF00619
(CARD) 		5 PHE S  73
CYH S  76
PHE S  35
LEU S  58
LEU S  20
 None
 0.97A 4xumA-5wveS:
undetectable		 4xumA-5wveS:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xh9 EXTRACELLULAR
INVERTASE

(Aspergillus
kawachii) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		5 ILE A 289
LEU A 207
LEU A 245
LEU A 231
TYR A 215
 None
 1.31A 4xumA-5xh9A:
undetectable		 4xumA-5xh9A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ykb TREHALOSE SYNTHASE

(Deinococcus
radiodurans) 		no annotation 5 PHE A  14
ILE A 305
PHE A 275
LEU A 249
LEU A 247
 None
 1.28A 4xumA-5ykbA:
undetectable		 4xumA-5ykbA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bxa TOLL-LIKE RECEPTOR
5B, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA

(Danio rerio;
Eptatretus
burgeri) 		no annotation 5 ILE A 161
MET A 212
LEU A 236
LEU A 234
LEU A 202
 None
 1.09A 4xumA-6bxaA:
undetectable		 4xumA-6bxaA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bxa VARIABLE LYMPHOCYTE
RECEPTOR 2

(Petromyzon
marinus) 		no annotation 5 PHE C  93
ILE C  47
LEU C  64
LEU C  80
LEU C  56
 None
 1.28A 4xumA-6bxaC:
undetectable		 4xumA-6bxaC:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c5w CALCIUM UNIPORTER

(Metarhizium
acridum) 		no annotation 5 PHE A 249
ILE A 253
LEU A 158
LEU A 114
LEU A 116
 None
 1.29A 4xumA-6c5wA:
undetectable		 4xumA-6c5wA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6v TELOMERASE REVERSE
TRANSCRIPTASE

(Tetrahymena
thermophila) 		no annotation 5 PHE A 151
PHE A 148
LEU A 139
LEU A  36
LEU A  40
 None
 1.28A 4xumA-6d6vA:
undetectable		 4xumA-6d6vA:
14.55