SIMILAR PATTERNS OF AMINO ACIDS FOR 4XTA_B_DIFB501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bs0 PROTEIN
(8-AMINO-7-OXONANOAT
E SYNTHASE)

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		4 ILE A  58
ARG A 284
LEU A  93
ILE A 283
 None
 0.95A 4xtaB-1bs0A:
0.0		 4xtaB-1bs0A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fb5 ORNITHINE
TRANSCARBAMOYLASE

(Ovis aries) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 ILE A 261
CYH A 303
ARG A 330
ILE A 172
 None
 0.93A 4xtaB-1fb5A:
0.0		 4xtaB-1fb5A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flo FLP RECOMBINASE

(Saccharomyces
cerevisiae) 		PF03930
(Flp_N)
PF05202
(Flp_C) 		4 ILE A 215
CYH A 217
LEU A 274
ILE A 407
 None
 0.88A 4xtaB-1floA:
0.0		 4xtaB-1floA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fvf SEC1

(Doryteuthis
pealeii) 		PF00995
(Sec1) 		4 ILE A 430
LEU A 240
LEU A 581
ILE A 437
 None
 0.98A 4xtaB-1fvfA:
0.0		 4xtaB-1fvfA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gng FRATTIDE
GLYCOGEN SYNTHASE
KINASE-3 BETA

(Homo sapiens) 		PF00069
(Pkinase)
PF05350
(GSK-3_bind) 		4 ILE A 269
ARG X 219
LEU X 203
LEU X 206
 None
 0.95A 4xtaB-1gngA:
0.0		 4xtaB-1gngA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h65 CHLOROPLAST OUTER
ENVELOPE PROTEIN
OEP34

(Pisum sativum) 		PF04548
(AIG1) 		4 ILE A  91
LEU A  25
LEU A  28
ILE A 239
 None
 0.93A 4xtaB-1h65A:
undetectable		 4xtaB-1h65A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j5y TRANSCRIPTIONAL
REGULATOR, BIOTIN
REPRESSOR FAMILY

(Thermotoga
maritima) 		PF02829
(3H)
PF08279
(HTH_11) 		4 ILE A  98
ARG A  73
LEU A 171
ILE A 161
 None
 0.74A 4xtaB-1j5yA:
undetectable		 4xtaB-1j5yA:
25.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jkw CYCLIN H

(Homo sapiens) 		PF00134
(Cyclin_N)
PF16899
(Cyclin_C_2) 		4 ILE A 172
SER A 210
LEU A 236
LEU A 232
 None
 0.99A 4xtaB-1jkwA:
undetectable		 4xtaB-1jkwA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k3r CONSERVED PROTEIN
MT0001

(Methanothermobacter
thermautotrophicus) 		PF02598
(Methyltrn_RNA_3) 		4 ILE A 231
LEU A   6
LEU A 254
MET A 207
 None
 0.99A 4xtaB-1k3rA:
undetectable		 4xtaB-1k3rA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k68 PHYTOCHROME RESPONSE
REGULATOR RCPA

(Tolypothrix sp.
PCC 7601) 		PF00072
(Response_reg) 		4 ILE A  26
SER A  33
LEU A 141
ILE A 136
 None
 0.88A 4xtaB-1k68A:
undetectable		 4xtaB-1k68A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lb4 TNF
RECEPTOR-ASSOCIATED
FACTOR 6

(Homo sapiens) 		no annotation 4 ILE A 488
LEU A 393
LEU A 409
ILE A 434
 None
 0.98A 4xtaB-1lb4A:
undetectable		 4xtaB-1lb4A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mv5 MULTIDRUG RESISTANCE
ABC TRANSPORTER
ATP-BINDING AND
PERMEASE PROTEIN

(Lactococcus
lactis) 		PF00005
(ABC_tran) 		4 ILE A 385
ARG A 391
ILE A 400
MET A 503
 None
 0.97A 4xtaB-1mv5A:
undetectable		 4xtaB-1mv5A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n94 PROTEIN
FARNESYLTRANSFERASE
BETA SUBUNIT

(Rattus
norvegicus) 		PF00432
(Prenyltrans) 		4 ILE B 261
LEU B 181
LEU B 178
ILE B 217
 None
 0.98A 4xtaB-1n94B:
undetectable		 4xtaB-1n94B:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oaa SEPIAPTERIN
REDUCTASE

(Mus musculus) 		PF00106
(adh_short) 		4 ILE A  99
ARG A  22
LEU A  55
MET A  38
 None
 0.99A 4xtaB-1oaaA:
undetectable		 4xtaB-1oaaA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qlm METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE

(Methanopyrus
kandleri) 		PF02289
(MCH) 		4 CYH A  56
SER A 109
LEU A 166
ILE A 136
 None
 0.93A 4xtaB-1qlmA:
undetectable		 4xtaB-1qlmA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s1f PUTATIVE CYTOCHROME
P450

(Streptomyces
coelicolor) 		PF00067
(p450) 		4 ILE A 285
SER A 259
LEU A 400
LEU A 144
 None
 0.95A 4xtaB-1s1fA:
undetectable		 4xtaB-1s1fA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1to6 GLYCERATE KINASE

(Neisseria
meningitidis) 		PF02595
(Gly_kinase) 		4 ILE A 143
CYH A 252
LEU A 189
ILE A 129
 None
 0.94A 4xtaB-1to6A:
undetectable		 4xtaB-1to6A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u78 TRANSPOSABLE ELEMENT
TC3 TRANSPOSASE

(Caenorhabditis
elegans) 		PF01498
(HTH_Tnp_Tc3_2)
PF11427
(HTH_Tnp_Tc3_1) 		4 ARG A  84
SER A  92
LEU A  61
ILE A  83
 None
 0.94A 4xtaB-1u78A:
undetectable		 4xtaB-1u78A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v8b ADENOSYLHOMOCYSTEINA
SE

(Plasmodium
falciparum) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 ILE A  49
LEU A  31
LEU A  61
ILE A  63
 None
 0.93A 4xtaB-1v8bA:
undetectable		 4xtaB-1v8bA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vgm 378AA LONG
HYPOTHETICAL CITRATE
SYNTHASE

(Sulfurisphaera
tokodaii) 		PF00285
(Citrate_synt) 		4 ILE A  69
SER A 156
LEU A 178
ILE A 125
 None
 0.99A 4xtaB-1vgmA:
undetectable		 4xtaB-1vgmA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa5 IMPORTIN ALPHA
RE-EXPORTER

(Saccharomyces
cerevisiae) 		PF03378
(CAS_CSE1)
PF03810
(IBN_N)
PF08506
(Cse1) 		4 LEU C 269
LEU C 272
ILE C 221
MET C 233
 None
 0.98A 4xtaB-1wa5C:
undetectable		 4xtaB-1wa5C:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wch PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 13

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 ILE A2421
LEU A2204
LEU A2207
ILE A2436
 None
 0.95A 4xtaB-1wchA:
undetectable		 4xtaB-1wchA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wrm DUAL SPECIFICITY
PHOSPHATASE 22

(Homo sapiens) 		PF00782
(DSPc) 		4 ILE A  14
SER A  70
LEU A  63
ILE A 100
 None
 0.98A 4xtaB-1wrmA:
undetectable		 4xtaB-1wrmA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xpo RHO TRANSCRIPTION
TERMINATION FACTOR

(Escherichia
coli) 		PF00006
(ATP-synt_ab)
PF07497
(Rho_RNA_bind)
PF07498
(Rho_N) 		4 ILE A 176
LEU A 145
ILE A 191
MET A 341
 None
 0.97A 4xtaB-1xpoA:
undetectable		 4xtaB-1xpoA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ydx TYPE I RESTRICTION
ENZYME SPECIFICITY
PROTEIN MG438

(Mycoplasma
genitalium) 		PF01420
(Methylase_S) 		4 ILE A 129
LEU A  94
LEU A  21
ILE A  18
 None
 0.95A 4xtaB-1ydxA:
undetectable		 4xtaB-1ydxA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ynq OXIDOREDUCTASE

(Bacillus
halodurans) 		PF00248
(Aldo_ket_red) 		4 ILE A 186
SER A   9
LEU A 115
ILE A 165
 None
 0.76A 4xtaB-1ynqA:
undetectable		 4xtaB-1ynqA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A

(Homo sapiens) 		PF00233
(PDEase_I) 		4 ILE A 318
LEU A 170
LEU A 198
ILE A 247
 None
 0.99A 4xtaB-1zklA:
undetectable		 4xtaB-1zklA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bf4 NADPH-CYTOCHROME
P450 REDUCTASE

(Saccharomyces
cerevisiae) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		4 ILE A 408
SER A 416
LEU A 387
LEU A 390
 None
 0.98A 4xtaB-2bf4A:
undetectable		 4xtaB-2bf4A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bra NEDD9 INTERACTING
PROTEIN WITH
CALPONIN HOMOLOGY
AND LIM DOMAINS

(Mus musculus) 		PF01494
(FAD_binding_3) 		5 ILE A 215
ARG A 377
SER A 374
LEU A 433
MET A 419
 None
 1.42A 4xtaB-2braA:
undetectable		 4xtaB-2braA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btv PROTEIN (VP3 CORE
PROTEIN)

(Bluetongue
virus) 		PF01700
(Orbi_VP3) 		4 ILE A 354
LEU A 576
LEU A 380
MET A 394
 None
 0.89A 4xtaB-2btvA:
undetectable		 4xtaB-2btvA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkd PHOSPHOACETYLGLUCOSA
MINE MUTASE

(Candida
albicans) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I) 		4 SER A 245
LEU A 443
LEU A 440
ILE A 232
 None
 0.91A 4xtaB-2dkdA:
undetectable		 4xtaB-2dkdA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dyu FORMAMIDASE

(Helicobacter
pylori) 		PF00795
(CN_hydrolase) 		4 ARG A 188
LEU A 174
ILE A 165
MET A 150
 None
 0.97A 4xtaB-2dyuA:
undetectable		 4xtaB-2dyuA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e11 HYDROLASE

(Xanthomonas
campestris) 		PF00795
(CN_hydrolase) 		4 ILE A   6
LEU A  95
LEU A 129
ILE A 138
 None
 0.91A 4xtaB-2e11A:
undetectable		 4xtaB-2e11A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hku A PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Rhodococcus
jostii) 		PF00440
(TetR_N)
PF16914
(TetR_C_12) 		4 SER A  60
LEU A 125
LEU A 128
MET A 118
 None
 0.85A 4xtaB-2hkuA:
undetectable		 4xtaB-2hkuA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7x PROTEIN CFT2

(Saccharomyces
cerevisiae) 		PF16661
(Lactamase_B_6) 		4 ILE A 164
CYH A 166
SER A 168
ILE A 210
 None
 0.81A 4xtaB-2i7xA:
undetectable		 4xtaB-2i7xA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgp TYROCIDINE
SYNTHETASE 3

(Brevibacillus
brevis) 		PF00550
(PP-binding)
PF00668
(Condensation) 		4 ILE A 514
LEU A 316
LEU A 502
ILE A 504
 None
 0.99A 4xtaB-2jgpA:
undetectable		 4xtaB-2jgpA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jk1 HYDROGENASE
TRANSCRIPTIONAL
REGULATORY PROTEIN
HUPR1

(Rhodobacter
capsulatus) 		PF00072
(Response_reg) 		4 ILE A 100
SER A 116
LEU A  10
ILE A  52
 None
 0.94A 4xtaB-2jk1A:
undetectable		 4xtaB-2jk1A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l5y STROMAL INTERACTION
MOLECULE 2

(Homo sapiens) 		PF07647
(SAM_2) 		4 ILE A 121
SER A  92
LEU A 203
LEU A 199
 None
 0.92A 4xtaB-2l5yA:
undetectable		 4xtaB-2l5yA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l7e TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 14

(Saccharomyces
cerevisiae) 		PF03366
(YEATS) 		4 ILE A  55
ARG A  10
LEU A  39
ILE A   9
 None
 0.91A 4xtaB-2l7eA:
undetectable		 4xtaB-2l7eA:
18.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 ILE A 272
SER A 280
LEU A 321
MET A 355
 735  A 469 ( 4.2A)
735  A 469 (-2.8A)
735  A 469 ( 4.3A)
735  A 469 (-2.9A)
 0.61A 4xtaB-2p54A:
33.4		 4xtaB-2p54A:
61.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phc UNCHARACTERIZED
PROTEIN PH0987

(Pyrococcus
horikoshii) 		PF02682
(CT_C_D) 		4 ILE B 185
LEU B 128
LEU B 201
ILE B 199
 None
 0.84A 4xtaB-2phcB:
undetectable		 4xtaB-2phcB:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pla GLYCEROL-3-PHOSPHATE
DEHYDROGENASE 1-LIKE
PROTEIN

(Homo sapiens) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		4 ILE A 138
ARG A 102
LEU A  81
ILE A  95
 None
NAD  A 401 (-3.7A)
None
None
 0.88A 4xtaB-2plaA:
undetectable		 4xtaB-2plaA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qen WALKER-TYPE ATPASE

(Pyrococcus
abyssi) 		PF01637
(ATPase_2) 		4 ILE A  60
SER A  86
LEU A 101
LEU A 123
 None
 0.98A 4xtaB-2qenA:
undetectable		 4xtaB-2qenA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfq 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Escherichia
coli) 		PF00275
(EPSP_synthase) 		4 SER A  25
LEU A  54
LEU A  57
ILE A  75
 None
 0.98A 4xtaB-2qfqA:
undetectable		 4xtaB-2qfqA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qwv UPF0217 PROTEIN
VC_A1059

(Vibrio cholerae) 		PF04013
(Methyltrn_RNA_2) 		4 ILE A  69
SER A   7
LEU A 127
LEU A 124
 None
 0.97A 4xtaB-2qwvA:
undetectable		 4xtaB-2qwvA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uxt PROTEIN SUFI

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ILE A 293
SER A 317
LEU A 213
ILE A 186
 None
 0.97A 4xtaB-2uxtA:
undetectable		 4xtaB-2uxtA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wd9 ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL

(Homo sapiens) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 ILE A 357
LEU A 300
LEU A 297
MET A 308
 None
 0.87A 4xtaB-2wd9A:
undetectable		 4xtaB-2wd9A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wdu GLUTATHIONE
TRANSFERASE SIGMA
CLASS

(Fasciola
hepatica) 		PF14497
(GST_C_3) 		4 SER A 195
LEU A 161
LEU A  22
MET A  84
 None
 0.90A 4xtaB-2wduA:
undetectable		 4xtaB-2wduA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wk2 CHITINASE A

(Serratia
marcescens) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		4 ILE A 194
SER A 203
LEU A 326
ILE A 200
 None
 0.97A 4xtaB-2wk2A:
undetectable		 4xtaB-2wk2A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wry INTERLEUKIN-1BETA

(Gallus gallus) 		PF00340
(IL1) 		4 ILE A  48
LEU A  30
ILE A  14
MET A  78
 None
 0.99A 4xtaB-2wryA:
undetectable		 4xtaB-2wryA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4h HYPOTHETICAL PROTEIN
SSO2273

(Sulfolobus
solfataricus) 		PF01325
(Fe_dep_repress)
PF02742
(Fe_dep_repr_C) 		4 SER A  11
LEU A  54
LEU A  59
ILE A  77
 None
 0.99A 4xtaB-2x4hA:
undetectable		 4xtaB-2x4hA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x5d PROBABLE
AMINOTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00155
(Aminotran_1_2) 		4 ILE A 226
ARG A 195
LEU A 161
MET A 175
 None
 0.92A 4xtaB-2x5dA:
undetectable		 4xtaB-2x5dA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xkr PUTATIVE CYTOCHROME
P450 142

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		4 ILE A  65
LEU A 225
LEU A 228
MET A  74
 None
None
None
PG4  A1399 ( 4.4A)
 0.96A 4xtaB-2xkrA:
undetectable		 4xtaB-2xkrA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y6e UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 4

(Homo sapiens) 		PF00443
(UCH) 		5 ILE A 868
CYH A 319
SER A 315
LEU A 398
LEU A 401
 None
None
CME  A 311 ( 4.7A)
None
None
 1.13A 4xtaB-2y6eA:
undetectable		 4xtaB-2y6eA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z0m 337AA LONG
HYPOTHETICAL
ATP-DEPENDENT RNA
HELICASE DEAD

(Sulfurisphaera
tokodaii) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 ILE A 125
ARG A 160
SER A 158
ILE A 153
 None
 0.98A 4xtaB-2z0mA:
undetectable		 4xtaB-2z0mA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zu6 EUKARYOTIC
INITIATION FACTOR
4A-I

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 LEU A 263
LEU A 266
ILE A 272
MET A 292
 None
 0.93A 4xtaB-2zu6A:
undetectable		 4xtaB-2zu6A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqc COMPONENT A OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE

(Micrococcus
luteus) 		no annotation 4 ILE A  31
LEU A  75
LEU A  78
ILE A   7
 None
 0.92A 4xtaB-3aqcA:
undetectable		 4xtaB-3aqcA:
20.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 CYH A 285
ARG A 288
LEU A 330
LEU A 333
ILE A 341
MET A 364
 MC5  A   1 (-3.6A)
None
MC5  A   1 (-4.4A)
None
MC5  A   1 (-4.5A)
MC5  A   1 (-3.7A)
 0.83A 4xtaB-3b0qA:
36.3		 4xtaB-3b0qA:
98.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 ILE A 281
ARG A 288
LEU A 330
LEU A 333
ILE A 341
MET A 364
 MC5  A   1 ( 4.8A)
None
MC5  A   1 (-4.4A)
None
MC5  A   1 (-4.5A)
MC5  A   1 (-3.7A)
 0.51A 4xtaB-3b0qA:
36.3		 4xtaB-3b0qA:
98.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 ILE A 281
ARG A 288
SER A 289
LEU A 330
LEU A 333
MET A 364
 MC5  A   1 ( 4.8A)
None
MC5  A   1 (-2.6A)
MC5  A   1 (-4.4A)
None
MC5  A   1 (-3.7A)
 0.57A 4xtaB-3b0qA:
36.3		 4xtaB-3b0qA:
98.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjd PUTATIVE
3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE

(Pseudomonas
aeruginosa) 		PF14515
(HOASN)
PF14518
(Haem_oxygenas_2) 		4 ILE A  35
ARG A  20
LEU A  11
LEU A   8
 None
 0.87A 4xtaB-3bjdA:
undetectable		 4xtaB-3bjdA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvg PUTATIVE METAL
BINDING PROTEIN

(Coccidioides
immitis) 		PF12849
(PBP_like_2) 		4 ILE A 143
LEU A 166
ILE A 220
MET A 150
 None
 0.98A 4xtaB-3cvgA:
undetectable		 4xtaB-3cvgA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1r FRUCTOSE-1,6-BISPHOS
PHATASE CLASS II
GLPX

(Escherichia
coli) 		PF03320
(FBPase_glpX) 		4 ILE A 124
SER A 200
LEU A 290
LEU A 306
 None
MG  A3504 (-3.9A)
None
None
 0.99A 4xtaB-3d1rA:
undetectable		 4xtaB-3d1rA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dli METHYLTRANSFERASE

(Archaeoglobus
fulgidus) 		PF13489
(Methyltransf_23) 		4 ILE A 332
SER A 369
LEU A 415
LEU A 412
 None
 0.99A 4xtaB-3dliA:
undetectable		 4xtaB-3dliA:
23.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		7 ILE D 281
CYH D 285
SER D 289
LEU D 330
LEU D 333
ILE D 341
MET D 364
 PLB  D 701 (-4.6A)
PLB  D 701 (-3.2A)
PLB  D 701 ( 3.9A)
PLB  D 701 ( 4.1A)
PLB  D 701 (-4.4A)
PLB  D 701 (-3.6A)
PLB  D 701 ( 4.8A)
 0.46A 4xtaB-3dzuD:
33.7		 4xtaB-3dzuD:
91.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3emv URIDINE
PHOSPHORYLASE,
PUTATIVE

(Plasmodium
vivax) 		PF01048
(PNP_UDP_1) 		4 ILE A 108
LEU A  21
LEU A 235
ILE A 233
 None
 0.94A 4xtaB-3emvA:
undetectable		 4xtaB-3emvA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f0n MEVALONATE
PYROPHOSPHATE
DECARBOXYLASE

(Mus musculus) 		PF00288
(GHMP_kinases_N) 		4 CYH A 160
SER A 149
LEU A  33
ILE A  32
 None
None
None
PO4  A 401 ( 4.6A)
 0.98A 4xtaB-3f0nA:
undetectable		 4xtaB-3f0nA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f59 ANKYRIN-1

(Homo sapiens) 		PF00791
(ZU5) 		4 ILE A 949
CYH A 951
ARG A 952
LEU A1061
 None
 0.71A 4xtaB-3f59A:
undetectable		 4xtaB-3f59A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ffr PHOSPHOSERINE
AMINOTRANSFERASE
SERC

(Cytophaga
hutchinsonii) 		PF00266
(Aminotran_5) 		4 ILE A 124
ARG A 155
ILE A 133
MET A 146
 None
 0.99A 4xtaB-3ffrA:
undetectable		 4xtaB-3ffrA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3frk QDTB

(Thermoanaerobacterium
thermosaccharolyticum) 		PF01041
(DegT_DnrJ_EryC1) 		4 ILE A 358
LEU A 295
LEU A 341
ILE A 343
 None
 0.73A 4xtaB-3frkA:
undetectable		 4xtaB-3frkA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxa SIS DOMAIN PROTEIN

(Listeria
monocytogenes) 		PF01380
(SIS) 		4 ILE A  40
SER A 119
LEU A  97
ILE A 122
 None
 0.96A 4xtaB-3fxaA:
undetectable		 4xtaB-3fxaA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hin PUTATIVE
3-HYDROXYBUTYRYL-COA
DEHYDRATASE

(Rhodopseudomonas
palustris) 		PF00378
(ECH_1) 		4 ILE A 102
SER A  72
LEU A  44
ILE A  29
 None
 0.99A 4xtaB-3hinA:
undetectable		 4xtaB-3hinA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hww 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE-1-CARBOXYLA
TE SYNTHASE

(Escherichia
coli) 		PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
PF16582
(TPP_enzyme_M_2) 		4 ILE A 134
LEU A  90
LEU A 100
ILE A 101
 None
 0.99A 4xtaB-3hwwA:
undetectable		 4xtaB-3hwwA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iq0 PUTATIVE RIBOKINASE
II

(Escherichia
coli) 		PF00294
(PfkB) 		4 ILE A  42
SER A 138
LEU A 116
ILE A  10
 None
 0.99A 4xtaB-3iq0A:
undetectable		 4xtaB-3iq0A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ir4 GLUTAREDOXIN 2

(Salmonella
enterica) 		PF04399
(Glutaredoxin2_C)
PF13417
(GST_N_3) 		4 ILE A   5
LEU A 210
LEU A 209
ILE A 207
 None
 0.79A 4xtaB-3ir4A:
undetectable		 4xtaB-3ir4A:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ixl ARYLMALONATE
DECARBOXYLASE

(Bordetella
bronchiseptica) 		no annotation 4 SER A  76
LEU A  40
LEU A  38
ILE A  52
 PAC  A5000 (-2.6A)
None
None
None
 0.95A 4xtaB-3ixlA:
undetectable		 4xtaB-3ixlA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kmh D-LYXOSE ISOMERASE

(Escherichia
coli) 		PF07385
(Lyx_isomer) 		4 ILE A  91
LEU A 120
LEU A 157
ILE A 113
 None
 0.78A 4xtaB-3kmhA:
undetectable		 4xtaB-3kmhA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ld8 ANTIBODY FAB
FRAGMENT LIGHT CHAIN
BIFUNCTIONAL
ARGININE DEMETHYLASE
AND
LYSYL-HYDROXYLASE
JMJD6

(Cricetulus
migratorius;
Homo sapiens) 		PF02373
(JmjC)
PF07654
(C1-set)
PF07686
(V-set) 		4 ARG A  65
LEU B  29
LEU B  38
MET B   4
 None
 0.99A 4xtaB-3ld8A:
undetectable		 4xtaB-3ld8A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mlx HUMAN MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY 3074 FAB
HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ILE H  51
ARG H  94
LEU H   4
ILE H  29
 None
 0.98A 4xtaB-3mlxH:
undetectable		 4xtaB-3mlxH:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzy RNA POLYMERASE
SIGMA-H FACTOR

(Fusobacterium
nucleatum) 		PF04542
(Sigma70_r2) 		4 ILE A 139
SER A 192
LEU A 158
LEU A 161
 None
 0.91A 4xtaB-3mzyA:
undetectable		 4xtaB-3mzyA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0r RESPONSE REGULATOR

(Caulobacter
vibrioides) 		PF00072
(Response_reg) 		4 ILE A 116
LEU A  39
LEU A  36
ILE A  14
 None
 0.98A 4xtaB-3n0rA:
undetectable		 4xtaB-3n0rA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ndq TRANSCRIPTION
ELONGATION FACTOR A
PROTEIN 1

(Homo sapiens) 		PF07500
(TFIIS_M) 		4 ILE A 195
CYH A 144
ARG A 145
ILE A 172
 None
 0.95A 4xtaB-3ndqA:
undetectable		 4xtaB-3ndqA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nv9 MALIC ENZYME

(Entamoeba
histolytica) 		PF00390
(malic)
PF03949
(Malic_M) 		4 ILE A 158
SER A 185
LEU A 179
ILE A 165
 None
 0.96A 4xtaB-3nv9A:
undetectable		 4xtaB-3nv9A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzt GLUTAMATE--CYSTEINE
LIGASE

(Francisella
tularensis) 		PF04262
(Glu_cys_ligase) 		4 ILE A 133
SER A  49
LEU A  26
ILE A 129
 None
 0.86A 4xtaB-3nztA:
undetectable		 4xtaB-3nztA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o80 HEXOKINASE

(Kluyveromyces
lactis) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		4 ILE A 165
LEU A 249
LEU A 252
MET A 263
 None
 0.96A 4xtaB-3o80A:
undetectable		 4xtaB-3o80A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3of7 REGULATOR OF
CHROMOSOME
CONDENSATION

(Saccharomyces
cerevisiae) 		PF00415
(RCC1)
PF13540
(RCC1_2) 		4 SER A 406
LEU A 351
LEU A 345
ILE A 335
 None
 0.99A 4xtaB-3of7A:
undetectable		 4xtaB-3of7A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qdq 4-HYDROXYBUTYRATE
COA-TRANSFERASE

(Clostridium
aminobutyricum) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		4 SER A 210
LEU A 227
LEU A 224
ILE A 309
 None
 0.95A 4xtaB-3qdqA:
undetectable		 4xtaB-3qdqA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfv CDC42BPB PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A 214
ARG A 178
LEU A 275
ILE A 181
 None
 0.98A 4xtaB-3qfvA:
undetectable		 4xtaB-3qfvA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qw3 OROTIDINE-5-PHOSPHAT
E
DECARBOXYLASE/OROTAT
E
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE
(OMPDCASE-OPRTASE,
PUTATIVE)

(Leishmania
infantum) 		PF00215
(OMPdecase) 		4 ILE A 248
LEU A 184
ILE A 201
MET A 223
 None
 0.99A 4xtaB-3qw3A:
undetectable		 4xtaB-3qw3A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rju BETA-LACTAMASE/D-ALA
NINE
CARBOXYPEPTIDASE

(Yersinia pestis) 		PF00144
(Beta-lactamase) 		4 ARG A  56
SER A 211
LEU A  54
ILE A  55
 None
 1.00A 4xtaB-3rjuA:
undetectable		 4xtaB-3rjuA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rks HYDROXYNITRILASE

(Manihot
esculenta) 		PF00561
(Abhydrolase_1) 		4 ILE A  18
LEU A 149
LEU A 153
MET A 174
 None
 0.90A 4xtaB-3rksA:
undetectable		 4xtaB-3rksA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sil SIALIDASE

(Salmonella
enterica) 		PF13859
(BNR_3) 		4 ILE A 327
LEU A 319
LEU A 293
ILE A 287
 None
 0.98A 4xtaB-3silA:
undetectable		 4xtaB-3silA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sop NEURONAL-SPECIFIC
SEPTIN-3

(Homo sapiens) 		PF00735
(Septin) 		4 LEU A 309
LEU A 312
ILE A  64
MET A 119
 None
 0.99A 4xtaB-3sopA:
undetectable		 4xtaB-3sopA:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tac LIPRIN-ALPHA-2

(Homo sapiens) 		PF00536
(SAM_1)
PF07647
(SAM_2) 		4 CYH B1080
SER B1137
LEU B1032
ILE B1078
 None
 0.98A 4xtaB-3tacB:
undetectable		 4xtaB-3tacB:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tad LIPRIN-ALPHA-2

(Homo sapiens) 		PF00536
(SAM_1)
PF07647
(SAM_2) 		4 CYH A1080
SER A1137
LEU A1032
ILE A1078
 None
 0.93A 4xtaB-3tadA:
undetectable		 4xtaB-3tadA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thu MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME FAMILY
PROTEIN

(Sphingomonas
sp. SKA58) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A 212
LEU A 274
LEU A 279
ILE A 251
 None
 0.83A 4xtaB-3thuA:
undetectable		 4xtaB-3thuA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsm INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE

(Brucella
abortus) 		PF00218
(IGPS) 		4 ILE A 225
SER A  93
LEU A 169
LEU A 188
 None
 0.76A 4xtaB-3tsmA:
undetectable		 4xtaB-3tsmA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ud2 ANKYRIN-1

(Homo sapiens) 		no annotation 4 ILE C 949
CYH C 951
ARG C 952
LEU C1061
 None
 0.82A 4xtaB-3ud2C:
undetectable		 4xtaB-3ud2C:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ue3 SEPTUM FORMATION,
PENICILLIN BINDING
PROTEIN 3,
PEPTIDOGLYCAN
SYNTHETASE

(Acinetobacter
sp. ATCC 27244) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		4 ILE A 260
SER A  90
LEU A 208
ILE A 206
 None
 0.96A 4xtaB-3ue3A:
undetectable		 4xtaB-3ue3A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uf6 LMO1369 PROTEIN

(Listeria
monocytogenes) 		PF01515
(PTA_PTB) 		4 ILE A 196
SER A 222
LEU A 229
ILE A 228
 None
 0.88A 4xtaB-3uf6A:
undetectable		 4xtaB-3uf6A:
20.68