SIMILAR PATTERNS OF AMINO ACIDS FOR 4XT8_A_TMQA302_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bdg HEXOKINASE

(Schistosoma
mansoni) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 ILE A 229
GLY A 414
ASP A 209
GLU A 294
THR A 210
 GLC  A 501 (-4.1A)
SO4  A 502 ( 3.8A)
GLC  A 501 (-3.0A)
GLC  A 501 (-3.2A)
GLC  A 501 ( 4.3A)
 1.32A 4xt8A-1bdgA:
undetectable		 4xt8A-1bdgA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eun KDPG ALDOLASE

(Escherichia
coli) 		PF01081
(Aldolase) 		5 ILE A  57
GLY A  87
ALA A  88
GLU A  85
GLU A  82
 None
 1.33A 4xt8A-1eunA:
undetectable		 4xt8A-1eunA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)

(Allochromatium
vinosum) 		PF07992
(Pyr_redox_2)
PF09242
(FCSD-flav_bind) 		5 ILE A 352
SER A 368
GLY A 369
ALA A 351
GLU A 363
 None
 1.23A 4xt8A-1fcdA:
undetectable		 4xt8A-1fcdA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ik6 PYRUVATE
DEHYDROGENASE

(Pyrobaculum
aerophilum) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 GLY A  69
ALA A  71
GLU A  97
GLU A  64
THR A  60
 None
 1.32A 4xt8A-1ik6A:
undetectable		 4xt8A-1ik6A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT

(Klebsiella
pneumoniae) 		PF02286
(Dehydratase_LU) 		5 ILE A 534
SER A 535
ASP A 398
ARG A 402
GLU A 541
 None
 1.33A 4xt8A-1iwpA:
undetectable		 4xt8A-1iwpA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j8s PYELONEPHRITIC
ADHESIN

(Escherichia
coli) 		PF03627
(PapG_N) 		5 ASN A   3
GLY A 115
ALA A  50
PHE A 163
TYR A   7
 None
 1.10A 4xt8A-1j8sA:
undetectable		 4xt8A-1j8sA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ko7 HPR
KINASE/PHOSPHATASE

(Staphylococcus
xylosus) 		PF02603
(Hpr_kinase_N)
PF07475
(Hpr_kinase_C) 		5 ASN A 208
ILE A 218
SER A 217
GLY A 216
ALA A 215
 None
 1.20A 4xt8A-1ko7A:
undetectable		 4xt8A-1ko7A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A

(Rattus
norvegicus) 		PF01593
(Amino_oxidase) 		5 ASN A  75
GLY A 447
ARG A  79
GLU A 450
GLU A 475
 None
 1.22A 4xt8A-1o5wA:
undetectable		 4xt8A-1o5wA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oy1 PUTATIVE SIGMA
CROSS-REACTING
PROTEIN 27A

(Escherichia
coli) 		no annotation 5 ILE A  73
SER A  20
GLY A  13
ALA A  70
THR A  74
 None
 1.22A 4xt8A-1oy1A:
undetectable		 4xt8A-1oy1A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		5 SER A 633
ALA A 481
ASP A 532
PHE A 529
THR A 670
 GOL  A 701 (-3.0A)
None
None
None
None
 1.21A 4xt8A-1q3xA:
undetectable		 4xt8A-1q3xA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qrr SULFOLIPID
BIOSYNTHESIS (SQD1)
PROTEIN

(Arabidopsis
thaliana) 		PF01370
(Epimerase) 		5 ILE A 193
SER A 190
ALA A 194
GLU A 148
TYR A 149
 None
 1.32A 4xt8A-1qrrA:
undetectable		 4xt8A-1qrrA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rk2 RIBOKINASE

(Escherichia
coli) 		PF00294
(PfkB) 		5 ILE A  13
SER A  12
GLY A  44
ALA A  45
GLU A 143
 None
None
None
None
RIB  A 311 (-2.5A)
 1.20A 4xt8A-1rk2A:
undetectable		 4xt8A-1rk2A:
26.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sgf NERVE GROWTH FACTOR

(Mus musculus) 		PF00089
(Trypsin) 		5 SER A 195
ALA A  55
ASP A 102
GLU A 218
THR A 229
 None
 1.06A 4xt8A-1sgfA:
undetectable		 4xt8A-1sgfA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vc4 INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE

(Thermus
thermophilus) 		PF00218
(IGPS) 		5 GLY A 174
ALA A 175
ARG A 205
GLU A 172
GLU A 168
 None
 1.04A 4xt8A-1vc4A:
undetectable		 4xt8A-1vc4A:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vi1 FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX

(Bacillus
subtilis) 		PF02504
(FA_synthesis) 		5 ILE A 202
SER A 159
GLY A 158
ALA A 155
THR A 199
 None
 1.30A 4xt8A-1vi1A:
undetectable		 4xt8A-1vi1A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wz8 ENOYL-COA HYDRATASE

(Thermus
thermophilus) 		PF00378
(ECH_1) 		5 ILE A  76
SER A  72
GLY A  71
ARG A  88
GLU A  78
 MPD  A3003 ( 4.9A)
None
MPD  A3003 ( 4.1A)
None
None
 1.08A 4xt8A-1wz8A:
undetectable		 4xt8A-1wz8A:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8a HYPOTHETICAL PROTEIN
AF1437

(Archaeoglobus
fulgidus) 		no annotation 5 ASN A 231
ILE A 209
SER A 210
GLY A  52
ARG A 301
 None
None
None
None
MG  A 501 ( 4.7A)
 1.27A 4xt8A-1y8aA:
2.1		 4xt8A-1y8aA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8a HYPOTHETICAL PROTEIN
AF1437

(Archaeoglobus
fulgidus) 		no annotation 5 ASN A 231
ILE A 209
SER A 210
GLY A  52
ASP A  38
 None
 1.23A 4xt8A-1y8aA:
2.1		 4xt8A-1y8aA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzx GLUTATHIONE
S-TRANSFERASE KAPPA
1

(Homo sapiens) 		PF01323
(DSBA) 		5 GLY A 179
ALA A 180
PHE A  11
ARG A  40
GLU A   9
 None
 0.93A 4xt8A-1yzxA:
undetectable		 4xt8A-1yzxA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bb6 TRANSCOBALAMIN II

(Bos taurus) 		PF01122
(Cobalamin_bind) 		5 ILE A 317
SER A 340
GLY A 339
ALA A 338
PHE A 316
 None
 1.28A 4xt8A-2bb6A:
undetectable		 4xt8A-2bb6A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cxe RIBULOSE
BISPHOSPHATE
CARBOXYLASE

(Pyrococcus
horikoshii) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 ILE A 182
GLY A 180
ALA A 386
GLU A 219
THR A 157
 None
 1.24A 4xt8A-2cxeA:
2.1		 4xt8A-2cxeA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gah HETEROTETRAMERIC
SARCOSINE OXIDASE
ALPHA-SUBUNIT

(Stenotrophomonas
maltophilia) 		PF01571
(GCV_T)
PF07992
(Pyr_redox_2)
PF08669
(GCV_T_C)
PF13510
(Fer2_4) 		6 ILE A 515
SER A 516
GLY A 526
ALA A 529
GLU A 507
THR A 513
 None
 1.36A 4xt8A-2gahA:
undetectable		 4xt8A-2gahA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gah HETEROTETRAMERIC
SARCOSINE OXIDASE
ALPHA-SUBUNIT

(Stenotrophomonas
maltophilia) 		PF01571
(GCV_T)
PF07992
(Pyr_redox_2)
PF08669
(GCV_T_C)
PF13510
(Fer2_4) 		5 ILE A 515
SER A 525
GLY A 526
ALA A 529
THR A 513
 None
 1.25A 4xt8A-2gahA:
undetectable		 4xt8A-2gahA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hiv THERMOSTABLE DNA
LIGASE

(Sulfolobus
solfataricus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		5 ILE A  70
GLY A  92
ALA A  95
GLU A 167
THR A  74
 None
 1.30A 4xt8A-2hivA:
undetectable		 4xt8A-2hivA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o4c ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
PF11890
(DUF3410) 		5 ILE A 255
GLY A 257
ALA A 256
ASP A 232
THR A 252
 None
NAD  A1002 (-3.4A)
NAD  A1002 (-3.7A)
NAD  A1002 (-4.0A)
None
 1.09A 4xt8A-2o4cA:
undetectable		 4xt8A-2o4cA:
26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oda HYPOTHETICAL PROTEIN
PSPTO_2114

(Pseudomonas
syringae group
genomosp. 3) 		no annotation 5 SER A  14
GLY A  15
ALA A  22
ARG A 116
THR A  26
 None
 1.26A 4xt8A-2odaA:
undetectable		 4xt8A-2odaA:
21.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p4g HYPOTHETICAL PROTEIN

(Corynebacterium
diphtheriae) 		PF01872
(RibD_C) 		8 ILE A  40
GLY A  54
ASP A  61
ARG A  69
GLU A  85
TYR A  87
GLU A 193
THR A 214
 EDO  A 278 ( 3.9A)
None
EDO  A 278 (-3.2A)
EDO  A 275 (-2.8A)
EDO  A 284 ( 3.8A)
EDO  A 271 ( 4.0A)
None
None
 0.66A 4xt8A-2p4gA:
27.2		 4xt8A-2p4gA:
31.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p4g HYPOTHETICAL PROTEIN

(Corynebacterium
diphtheriae) 		PF01872
(RibD_C) 		8 ILE A  40
SER A  53
GLY A  54
ASP A  61
GLU A  85
TYR A  87
GLU A 193
THR A 214
 EDO  A 278 ( 3.9A)
EDO  A 280 ( 3.1A)
None
EDO  A 278 (-3.2A)
EDO  A 284 ( 3.8A)
EDO  A 271 ( 4.0A)
None
None
 0.78A 4xt8A-2p4gA:
27.2		 4xt8A-2p4gA:
31.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzu PUTATIVE SULFATASE
YIDJ

(Bacteroides
fragilis) 		PF00884
(Sulfatase) 		5 ILE A 261
ALA A 320
ASP A 260
TYR A 280
GLU A  49
 None
 1.24A 4xt8A-2qzuA:
undetectable		 4xt8A-2qzuA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w2k D-MANDELATE
DEHYDROGENASE

(Rhodotorula
graminis) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 ILE B 305
GLY B 307
ASP B 281
ARG B 257
THR B 302
 None
 1.32A 4xt8A-2w2kB:
undetectable		 4xt8A-2w2kB:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2woc ADP-RIBOSYL-[DINITRO
GEN REDUCTASE]
GLYCOHYDROLASE

(Rhodospirillum
rubrum) 		PF03747
(ADP_ribosyl_GH) 		5 ILE A  58
GLY A  56
ALA A  22
ASP A  21
THR A  62
 None
 1.19A 4xt8A-2wocA:
undetectable		 4xt8A-2wocA:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wwx DRRA

(Legionella
pneumophila) 		no annotation 5 SER B 399
GLY B 402
ALA B 404
ASP B 457
GLU B 361
 None
 1.32A 4xt8A-2wwxB:
undetectable		 4xt8A-2wwxB:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzf GLUCOSYLTRANSFERASE

(Legionella
pneumophila) 		PF16849
(Glyco_transf_88) 		5 ASN A 506
ILE A 275
SER A 274
GLY A 273
ALA A 501
 None
 1.33A 4xt8A-2wzfA:
undetectable		 4xt8A-2wzfA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xgo XCOGT

(Xanthomonas
campestris) 		PF13432
(TPR_16)
PF13844
(Glyco_transf_41) 		5 SER A 319
GLY A 320
ALA A 185
ARG A 304
GLU A 344
 None
 0.95A 4xt8A-2xgoA:
3.1		 4xt8A-2xgoA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zsg AMINOPEPTIDASE P,
PUTATIVE

(Thermotoga
maritima) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		5 GLY A 220
ALA A 228
ASP A 338
GLU A 322
THR A 350
 None
None
None
ZN  A1001 (-2.8A)
None
 1.34A 4xt8A-2zsgA:
undetectable		 4xt8A-2zsgA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3am6 RHODOPSIN-2

(Acetabularia
acetabulum) 		PF01036
(Bac_rhodopsin) 		5 ILE A 201
GLY A   9
ALA A  12
ARG A  78
GLU A 199
 None
 1.12A 4xt8A-3am6A:
undetectable		 4xt8A-3am6A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8u PURR TRANSCRIPTIONAL
REGULATOR

(Vibrio
parahaemolyticus) 		PF13377
(Peripla_BP_3) 		5 ILE A 155
GLY A 134
ALA A 156
TYR A 110
GLU A  82
 None
 1.06A 4xt8A-3d8uA:
undetectable		 4xt8A-3d8uA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwz BETA-LACTAMASE

(Mycobacterium
tuberculosis) 		PF13354
(Beta-lactamase2) 		5 GLY A 283
ALA A 282
ASP A 280
ARG A  75
GLU A  52
 None
 1.23A 4xt8A-3dwzA:
undetectable		 4xt8A-3dwzA:
24.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dyj TALIN-1

(Mus musculus) 		no annotation 5 SER A2279
GLY A2278
ALA A2277
GLU A2249
THR A2186
 None
 1.12A 4xt8A-3dyjA:
undetectable		 4xt8A-3dyjA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ebv CHINITASE A

(Streptomyces
coelicolor) 		PF00704
(Glyco_hydro_18) 		5 GLY A   9
ALA A  34
ASP A 117
TYR A 181
THR A 147
 None
 1.21A 4xt8A-3ebvA:
undetectable		 4xt8A-3ebvA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gv1 DISULFIDE
INTERCHANGE PROTEIN

(Neisseria
gonorrhoeae) 		PF13098
(Thioredoxin_2) 		5 ASN A 215
ILE A 212
SER A 211
GLY A 210
ARG A 193
 None
 1.16A 4xt8A-3gv1A:
undetectable		 4xt8A-3gv1A:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hd6 AMMONIUM TRANSPORTER
RH TYPE C

(Homo sapiens) 		PF00909
(Ammonium_transp) 		5 ASN A 342
ILE A 340
GLY A 192
ALA A 141
ASP A 336
 None
 1.19A 4xt8A-3hd6A:
undetectable		 4xt8A-3hd6A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hm8 HEXOKINASE-3

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 ILE A 683
GLY A 868
ASP A 663
GLU A 748
THR A 664
 GLC  A1001 (-4.2A)
BG6  A1002 (-3.5A)
GLC  A1001 ( 2.9A)
GLC  A1001 (-3.1A)
GLC  A1001 (-4.1A)
 1.33A 4xt8A-3hm8A:
undetectable		 4xt8A-3hm8A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3htx HEN1

(Arabidopsis
thaliana) 		PF13847
(Methyltransf_31) 		5 SER A 726
GLY A 725
ASP A 719
GLU A 796
THR A 793
 SAH  A 951 (-3.1A)
None
None
MG  A 950 ( 3.0A)
None
 1.29A 4xt8A-3htxA:
undetectable		 4xt8A-3htxA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ijp DIHYDRODIPICOLINATE
REDUCTASE

(Bartonella
henselae) 		PF01113
(DapB_N)
PF05173
(DapB_C) 		5 ILE A 217
GLY A 170
ALA A 173
ARG A 196
GLU A 149
 None
 1.31A 4xt8A-3ijpA:
undetectable		 4xt8A-3ijpA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iq0 PUTATIVE RIBOKINASE
II

(Escherichia
coli) 		PF00294
(PfkB) 		5 ILE A  40
SER A  35
GLY A  36
ALA A  37
ASP A 258
 None
 1.23A 4xt8A-3iq0A:
2.8		 4xt8A-3iq0A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jza UNCHARACTERIZED
PROTEIN DRRA

(Legionella
pneumophila) 		no annotation 5 SER B 399
GLY B 402
ALA B 404
PHE B 460
GLU B 361
 None
 1.22A 4xt8A-3jzaB:
undetectable		 4xt8A-3jzaB:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k5p D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Brucella
abortus) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 ILE A 294
SER A 297
GLY A 296
ASP A 265
THR A 291
 None
 0.94A 4xt8A-3k5pA:
undetectable		 4xt8A-3k5pA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k80 ANTIBODY

(Lama glama) 		PF07686
(V-set) 		5 SER A 105
GLY A 104
ALA A  50
PHE A  37
GLU A 110
 None
 1.29A 4xt8A-3k80A:
undetectable		 4xt8A-3k80A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kb3 PROTEIN PHOSPHATASE
2C 16

(Arabidopsis
thaliana) 		PF00481
(PP2C) 		5 ASN B 343
SER B 397
GLU B 371
GLU B 414
THR B 328
 None
None
None
None
MG  B 999 ( 4.0A)
 1.27A 4xt8A-3kb3B:
undetectable		 4xt8A-3kb3B:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krz NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE

(Thermoanaerobacter
pseudethanolicus) 		PF00724
(Oxidored_FMN) 		5 SER A  63
GLY A  65
ALA A  60
GLU A 113
TYR A 112
 None
 1.30A 4xt8A-3krzA:
1.7		 4xt8A-3krzA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7g XAA-PRO DIPEPTIDASE

(Alteromonas sp.) 		PF00557
(Peptidase_M24) 		5 ILE A 256
GLY A 246
ALA A 254
GLU A 381
THR A 434
 None
None
None
MN  A 519 ( 2.7A)
None
 1.30A 4xt8A-3l7gA:
undetectable		 4xt8A-3l7gA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m2r METHYL-COENZYME M
REDUCTASE I SUBUNIT
BETA

(Methanothermobacter
marburgensis) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		5 ILE B  85
GLY B  80
ALA B  82
ARG B 111
GLU B  54
 None
 1.28A 4xt8A-3m2rB:
undetectable		 4xt8A-3m2rB:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nra ASPARTATE
AMINOTRANSFERASE

(Rhodobacter
sphaeroides) 		PF00155
(Aminotran_1_2) 		5 ILE A 270
SER A 267
GLY A 266
GLU A 242
THR A 121
 None
 1.08A 4xt8A-3nraA:
undetectable		 4xt8A-3nraA:
24.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o1h PERIPLASMIC PROTEIN
TORT

(Vibrio
parahaemolyticus) 		PF00532
(Peripla_BP_1) 		5 ILE B 187
GLY B 148
ALA B 152
TYR B 141
GLU B 185
 None
 1.23A 4xt8A-3o1hB:
undetectable		 4xt8A-3o1hB:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oet ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE

(Salmonella
enterica) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
PF11890
(DUF3410) 		5 ILE A 255
GLY A 257
ALA A 256
ASP A 232
THR A 252
 None
NAD  A 379 (-3.6A)
NAD  A 379 (-3.8A)
NAD  A 379 (-4.1A)
None
 1.10A 4xt8A-3oetA:
undetectable		 4xt8A-3oetA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qk8 ENOYL-COA HYDRATASE
ECHA15

(Mycobacterium
marinum) 		PF00378
(ECH_1) 		5 ILE A  75
SER A  71
GLY A  70
ARG A  87
GLU A  77
 None
 1.25A 4xt8A-3qk8A:
undetectable		 4xt8A-3qk8A:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qnq PTS SYSTEM,
CELLOBIOSE-SPECIFIC
IIC COMPONENT

(Bacillus cereus) 		PF02378
(PTS_EIIC) 		5 ASN A 270
ILE A 284
GLY A 228
ALA A 229
THR A 283
 None
 1.30A 4xt8A-3qnqA:
undetectable		 4xt8A-3qnqA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rxz POLYSACCHARIDE
DEACETYLASE

(Mycolicibacterium
smegmatis) 		PF01522
(Polysacc_deac_1) 		5 ILE A 273
GLY A 269
ALA A 268
GLU A 100
GLU A 275
 None
 1.31A 4xt8A-3rxzA:
undetectable		 4xt8A-3rxzA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tmg GLYCINE BETAINE,
L-PROLINE ABC
TRANSPORTER,
GLYCINE/BETAINE/L-PR
OLINE-BINDING
PROTEIN (PROX)

(Borreliella
burgdorferi) 		PF04069
(OpuAC) 		5 ILE A  30
GLY A  77
PHE A  59
GLU A  57
THR A  42
 None
 1.26A 4xt8A-3tmgA:
undetectable		 4xt8A-3tmgA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u3x OXIDOREDUCTASE

(Sinorhizobium
meliloti) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 ILE A  39
GLY A  33
ALA A  95
GLU A  58
GLU A  66
 None
 1.33A 4xt8A-3u3xA:
undetectable		 4xt8A-3u3xA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vte TETRAHYDROCANNABINOL
IC ACID SYNTHASE

(Cannabis sativa) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 ILE A 431
GLY A 188
ALA A 201
ASP A 202
TYR A 387
 None
 1.25A 4xt8A-3vteA:
undetectable		 4xt8A-3vteA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo sapiens) 		PF01593
(Amino_oxidase) 		5 ASN A  66
GLY A 438
ARG A  70
GLU A 441
GLU A 466
 None
 1.21A 4xt8A-3zyxA:
undetectable		 4xt8A-3zyxA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4drs PYRUVATE KINASE

(Cryptosporidium
parvum) 		PF00224
(PK)
PF02887
(PK_C) 		5 ASN A 145
ILE A 149
GLY A 118
GLU A 197
GLU A 121
 None
 1.33A 4xt8A-4drsA:
2.4		 4xt8A-4drsA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4j ARGININE DEIMINASE

(Mycoplasma
penetrans) 		PF02274
(Amidinotransf) 		5 ASN A 331
ILE A 374
GLY A 376
ALA A 375
THR A 388
 None
 1.21A 4xt8A-4e4jA:
undetectable		 4xt8A-4e4jA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4exl PHOSPHATE-BINDING
PROTEIN PSTS 1

(Streptococcus
pneumoniae) 		PF12849
(PBP_like_2) 		5 ASN A 153
SER A 160
GLY A 159
ALA A 162
GLU A 179
 None
 1.23A 4xt8A-4exlA:
undetectable		 4xt8A-4exlA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4exl PHOSPHATE-BINDING
PROTEIN PSTS 1

(Streptococcus
pneumoniae) 		PF12849
(PBP_like_2) 		5 ASN A 153
SER A 160
GLY A 159
ASP A 165
GLU A 179
 None
 1.16A 4xt8A-4exlA:
undetectable		 4xt8A-4exlA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f9o HEXOKINASE-1

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 ILE A 229
GLY A 414
ASP A 209
GLU A 294
THR A 210
 BGC  A1001 (-4.2A)
0NZ  A1002 (-3.1A)
BGC  A1001 ( 3.0A)
BGC  A1001 (-2.6A)
BGC  A1001 (-4.0A)
 1.31A 4xt8A-4f9oA:
undetectable		 4xt8A-4f9oA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmv GLUCURONOARABINOXYLA
N
ENDO-1,4-BETA-XYLANA
SE

([Clostridium]
papyrosolvens) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		5 ILE A 263
GLY A  18
ALA A 261
ARG A 172
THR A 231
 None
 1.12A 4xt8A-4fmvA:
2.0		 4xt8A-4fmvA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gys ALLOPHANATE
HYDROLASE

(Granulibacter
bethesdensis) 		PF01425
(Amidase) 		5 GLY A  81
ALA A  80
ASP A  98
GLU A  48
GLU A  52
 None
 1.23A 4xt8A-4gysA:
undetectable		 4xt8A-4gysA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j1y COMPLEMENT C1S
SUBCOMPONENT

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		5 SER A 632
ALA A 473
ASP A 529
PHE A 526
THR A 666
 None
 1.32A 4xt8A-4j1yA:
undetectable		 4xt8A-4j1yA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4le5 S-ADENOSYLMETHIONINE
SYNTHETASE

(Campylobacter
jejuni) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		5 ILE A 144
SER A   6
ALA A 147
TYR A 177
GLU A 135
 None
 1.24A 4xt8A-4le5A:
undetectable		 4xt8A-4le5A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgr CAMELID NANOBODY
(VHH3)

(Vicugna pacos) 		PF07686
(V-set) 		5 ILE B  28
SER B  27
GLY B  26
ALA B  24
GLU B  99
 None
 1.07A 4xt8A-4lgrB:
undetectable		 4xt8A-4lgrB:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nbt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Acholeplasma
laidlawii) 		PF13561
(adh_short_C2) 		5 ASN A  80
ILE A 128
SER A 127
GLY A 126
TYR A  26
 None
 1.23A 4xt8A-4nbtA:
undetectable		 4xt8A-4nbtA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4npa PUTATIVE
UNCHARACTERIZED
PROTEIN

(Vibrio cholerae) 		PF03641
(Lysine_decarbox)
PF11892
(DUF3412)
PF14793
(DUF4478) 		5 ILE A 183
GLY A 173
ALA A 199
TYR A 166
GLU A 193
 None
 1.21A 4xt8A-4npaA:
undetectable		 4xt8A-4npaA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1e DIHYDROPTEROATE
SYNTHASE DHPS

(Desulfitobacterium
hafniense) 		PF00809
(Pterin_bind) 		5 ILE A  43
GLY A   6
ALA A  40
ARG A  34
THR A  71
 None
 1.28A 4xt8A-4o1eA:
undetectable		 4xt8A-4o1eA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqt D-HYDANTOINASE

(Brucella suis) 		PF01979
(Amidohydro_1) 		5 ILE A 414
GLY A 341
ALA A 320
ASP A  75
GLU A 345
 None
 1.26A 4xt8A-4tqtA:
1.8		 4xt8A-4tqtA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xrl MITOGEN-ACTIVATED
PROTEIN KINASE 1

(Rattus
norvegicus) 		PF00069
(Pkinase) 		5 ILE A  54
GLY A  35
ALA A  33
GLU A  58
THR A  66
 None
 1.30A 4xt8A-4xrlA:
undetectable		 4xt8A-4xrlA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwo ORGANOPHOSPHATE
ANHYDROLASE/PROLIDAS
E

(Alteromonas sp.) 		PF00557
(Peptidase_M24) 		5 ILE A 256
GLY A 246
ALA A 254
GLU A 381
THR A 434
 None
None
None
MN  A 501 ( 2.6A)
None
 1.31A 4xt8A-4zwoA:
undetectable		 4xt8A-4zwoA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a01 O-GLYCOSYLTRANSFERAS
E

(Drosophila
melanogaster) 		PF13374
(TPR_10)
PF13414
(TPR_11)
PF13844
(Glyco_transf_41) 		5 SER A 697
GLY A 698
ALA A 557
ARG A 682
GLU A 722
 None
 0.89A 4xt8A-5a01A:
3.6		 4xt8A-5a01A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dt9 ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE

(Vibrio cholerae) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
PF11890
(DUF3410) 		5 ILE A 262
GLY A 264
ALA A 263
ASP A 239
ARG A 215
 None
NAD  A 401 (-3.6A)
NAD  A 401 (-3.3A)
NAD  A 401 (-4.1A)
SO4  A 410 ( 3.5A)
 1.05A 4xt8A-5dt9A:
undetectable		 4xt8A-5dt9A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dt9 ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE

(Vibrio cholerae) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
PF11890
(DUF3410) 		5 ILE A 262
GLY A 264
ALA A 263
ASP A 239
THR A 259
 None
NAD  A 401 (-3.6A)
NAD  A 401 (-3.3A)
NAD  A 401 (-4.1A)
None
 1.08A 4xt8A-5dt9A:
undetectable		 4xt8A-5dt9A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fse UREASE SUBUNIT ALPHA

(Sporosarcina
pasteurii) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		5 ILE C 134
GLY C 425
ALA C 415
PHE C 494
THR C 136
 None
 1.13A 4xt8A-5fseC:
undetectable		 4xt8A-5fseC:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ht0 AMINOGLYCOSIDE
ACETYLTRANSFERASE
HMB0005

(uncultured
bacterium) 		PF02522
(Antibiotic_NAT) 		5 ILE A 234
SER A 239
GLY A 232
ASP A  14
GLU A 236
 None
 1.22A 4xt8A-5ht0A:
undetectable		 4xt8A-5ht0A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hx0 UNCHARACTERIZED
PROTEIN DFER_1899

(Dyadobacter
fermentans) 		PF13088
(BNR_2) 		5 ASN A 261
GLY A 308
ALA A 286
TYR A 365
GLU A 262
 PG4  A 401 ( 4.3A)
None
None
ACT  A 402 (-4.5A)
ACT  A 402 ( 4.6A)
 1.23A 4xt8A-5hx0A:
undetectable		 4xt8A-5hx0A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lhs UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR

(Mus musculus) 		no annotation 5 SER B 214
GLY B 196
ALA B  55
ASP B 102
THR B 229
 None
 1.31A 4xt8A-5lhsB:
undetectable		 4xt8A-5lhsB:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lhs UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR

(Mus musculus) 		no annotation 5 SER B 214
GLY B 196
ALA B  55
GLU B  96
THR B 229
 None
 1.19A 4xt8A-5lhsB:
undetectable		 4xt8A-5lhsB:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzn HELICASE
SEN1,HELICASE SEN1

(Saccharomyces
cerevisiae) 		PF13086
(AAA_11)
PF13087
(AAA_12) 		5 ILE A1602
SER A1570
GLY A1571
ALA A1573
THR A1297
 None
EDO  A2003 ( 4.1A)
EDO  A2003 (-3.3A)
None
None
 1.30A 4xt8A-5mznA:
undetectable		 4xt8A-5mznA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzn HELICASE
SEN1,HELICASE SEN1

(Saccharomyces
cerevisiae) 		PF13086
(AAA_11)
PF13087
(AAA_12) 		5 SER A1570
GLY A1571
ALA A1573
GLU A1292
THR A1297
 EDO  A2003 ( 4.1A)
EDO  A2003 (-3.3A)
None
None
None
 1.29A 4xt8A-5mznA:
undetectable		 4xt8A-5mznA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t38 EVDMO1

(Micromonospora
carbonacea) 		PF13847
(Methyltransf_31) 		5 ILE A  80
SER A  79
ARG A 108
GLU A 106
THR A  69
 None
 1.16A 4xt8A-5t38A:
undetectable		 4xt8A-5t38A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubm COMPLEMENT C1S
SUBCOMPONENT

(Homo sapiens) 		no annotation 5 SER A 632
ALA A 473
ASP A 529
PHE A 526
THR A 666
 None
 1.22A 4xt8A-5ubmA:
undetectable		 4xt8A-5ubmA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vsl RADICAL S-ADENOSYL
METHIONINE
DOMAIN-CONTAINING
PROTEIN 2

(Mus musculus) 		PF04055
(Radical_SAM)
PF13353
(Fer4_12) 		5 SER A 259
GLY A 260
ALA A 263
GLU A 268
THR A  94
 None
 1.20A 4xt8A-5vslA:
2.0		 4xt8A-5vslA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wq0 STAGE 0 SPORULATION
PROTEIN

(Paenisporosarcina
sp. TG-14) 		no annotation 5 ILE B   4
GLY B 124
ALA B 123
ASP B  51
GLU B   2
 None
 1.31A 4xt8A-5wq0B:
undetectable		 4xt8A-5wq0B:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1

(Streptococcus
pyogenes) 		PF13395
(HNH_4)
PF16592
(Cas9_REC)
PF16593
(Cas9-BH)
PF16595
(Cas9_PI) 		5 GLY A1165
ALA A1217
TYR A1187
GLU A1162
THR A1339
 None
 1.20A 4xt8A-5xblA:
undetectable		 4xt8A-5xblA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yjj POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Staphylococcus
epidermidis) 		no annotation 5 ILE A  95
SER A 134
GLY A 133
ALA A 130
THR A  91
 None
 1.27A 4xt8A-5yjjA:
undetectable		 4xt8A-5yjjA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zi9 CYTOKININ RIBOSIDE
5'-MONOPHOSPHATE
PHOSPHORIBOHYDROLASE

(Streptomyces
coelicolor) 		no annotation 5 ASN A 144
GLY A  97
ALA A 123
TYR A  90
GLU A 117
 None
 1.20A 4xt8A-5zi9A:
undetectable		 4xt8A-5zi9A:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b20 GUANINE
NUCLEOTIDE-BINDING
PROTEIN
G(I)/G(S)/G(T)
SUBUNIT BETA-1

(Bos taurus) 		no annotation 5 SER A 201
GLY A 202
ALA A 203
ASP A 205
THR A 184
 None
 1.25A 4xt8A-6b20A:
undetectable		 4xt8A-6b20A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6em0 2-HYDROXYBIPHENYL-3-
MONOOXYGENASE

(Pseudomonas
nitroreducens) 		no annotation 5 ILE A 175
SER A  21
GLY A  18
ALA A 177
ARG A 360
 None
 1.26A 4xt8A-6em0A:
undetectable		 4xt8A-6em0A:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6enz ACIDIC AMINO ACID
DECARBOXYLASE GADL1

(Mus musculus) 		no annotation 5 ILE A 479
SER A 480
GLY A 105
ALA A 104
PHE A  99
 None
 1.13A 4xt8A-6enzA:
undetectable		 4xt8A-6enzA:
15.12