SIMILAR PATTERNS OF AMINO ACIDS FOR 4XR4_B_AG2B511
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1aso | ASCORBATE OXIDASE (Cucurbita pepo) |
PF00394(Cu-oxidase)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 3 | VAL A 484PHE A 320ARG A 283 | None | 0.85A | 4xr4B-1asoA:undetectable | 4xr4B-1asoA:22.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bvs | PROTEIN (HOLLIDAYJUNCTION DNAHELICASE RUVA) (Mycobacteriumleprae) |
PF01330(RuvA_N)PF07499(RuvA_C)PF14520(HHH_5) | 3 | VAL A 28PHE A 62ARG A 68 | None | 0.92A | 4xr4B-1bvsA:undetectable | 4xr4B-1bvsA:22.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ez4 | LACTATEDEHYDROGENASE (Lactobacilluspentosus) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 3 | VAL A 121PHE A 129ARG A 157 | None | 0.89A | 4xr4B-1ez4A:7.4 | 4xr4B-1ez4A:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f82 | BOTULINUM NEUROTOXINTYPE B (Clostridiumbotulinum) |
PF01742(Peptidase_M27) | 3 | VAL A 135PHE A 128ARG A 301 | None | 0.92A | 4xr4B-1f82A:undetectable | 4xr4B-1f82A:22.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g6g | PROTEIN KINASE RAD53 (Saccharomycescerevisiae) |
PF00498(FHA) | 3 | VAL A 132PHE A 68ARG A 46 | None | 0.82A | 4xr4B-1g6gA:undetectable | 4xr4B-1g6gA:12.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gxn | PECTATE LYASE (Cellvibriojaponicus) |
PF09492(Pec_lyase) | 3 | VAL A 424PHE A 476ARG A 417 | None | 0.93A | 4xr4B-1gxnA:undetectable | 4xr4B-1gxnA:22.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hq0 | CYTOTOXICNECROTIZING FACTOR 1 (Escherichiacoli) |
PF05785(CNF1) | 3 | VAL A 856PHE A 758ARG A 777 | None | 0.65A | 4xr4B-1hq0A:undetectable | 4xr4B-1hq0A:20.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1itz | TRANSKETOLASE (Zea mays) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 3 | VAL A 636PHE A 596ARG A 496 | None | 0.96A | 4xr4B-1itzA:undetectable | 4xr4B-1itzA:21.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lvl | DIHYDROLIPOAMIDEDEHYDROGENASE (Pseudomonasputida) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 3 | VAL A 323PHE A 334ARG A 315 | None | 0.94A | 4xr4B-1lvlA:4.0 | 4xr4B-1lvlA:23.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mty | METHANEMONOOXYGENASEHYDROXYLASE (Methylococcuscapsulatus) |
PF02332(Phenol_Hydrox) | 3 | VAL D 154PHE D 79ARG D 146 | None | 0.99A | 4xr4B-1mtyD:undetectable | 4xr4B-1mtyD:21.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1now | BETA-HEXOSAMINIDASEBETA CHAIN (Homo sapiens) |
PF00728(Glyco_hydro_20)PF14845(Glycohydro_20b2) | 3 | VAL A 443PHE A 409ARG A 435 | None | 0.84A | 4xr4B-1nowA:undetectable | 4xr4B-1nowA:21.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qi9 | PROTEIN (VANADIUMBROMOPEROXIDASE) (Ascophyllumnodosum) |
no annotation | 3 | VAL A 213PHE A 152ARG A 196 | None | 0.81A | 4xr4B-1qi9A:undetectable | 4xr4B-1qi9A:25.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r71 | TRANSCRIPTIONALREPRESSOR PROTEINKORB (Escherichiacoli) |
PF08535(KorB) | 3 | VAL A 217PHE A 202ARG A 155 | None | 0.81A | 4xr4B-1r71A:undetectable | 4xr4B-1r71A:18.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1szi | MANNOSE-6-PHOSPHATERECEPTOR BINDINGPROTEIN 1 (Mus musculus) |
PF03036(Perilipin) | 3 | VAL A 390PHE A 334ARG A 335 | None | 0.89A | 4xr4B-1sziA:undetectable | 4xr4B-1sziA:23.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t8w | AMP NUCLEOSIDASE (Escherichiacoli) |
PF01048(PNP_UDP_1)PF10423(AMNp_N) | 3 | VAL A 126PHE A 146ARG A 47 | None | 0.98A | 4xr4B-1t8wA:undetectable | 4xr4B-1t8wA:24.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1urj | MAJOR DNA-BINDINGPROTEIN (Humanalphaherpesvirus1) |
PF00747(Viral_DNA_bp) | 3 | VAL A 65PHE A 61ARG A 193 | None | 0.93A | 4xr4B-1urjA:undetectable | 4xr4B-1urjA:18.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v4p | ALANYL-TRNASYNTHETASE (Pyrococcushorikoshii) |
no annotation | 3 | VAL A 44PHE A 137ARG A 48 | None | 0.84A | 4xr4B-1v4pA:undetectable | 4xr4B-1v4pA:14.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w36 | EXODEOXYRIBONUCLEASEV GAMMA CHAIN (Escherichiacoli) |
PF04257(Exonuc_V_gamma) | 3 | VAL C 12PHE C 326ARG C 272 | None | 0.86A | 4xr4B-1w36C:undetectable | 4xr4B-1w36C:19.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xtj | PROBABLEATP-DEPENDENT RNAHELICASE P47 (Homo sapiens) |
PF00270(DEAD)PF00271(Helicase_C) | 3 | VAL A 238PHE A 215ARG A 216 | None | 0.94A | 4xr4B-1xtjA:2.3 | 4xr4B-1xtjA:22.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zbx | ORIGIN RECOGNITIONCOMPLEX SUBUNIT 1 (Saccharomycescerevisiae) |
PF01426(BAH) | 3 | VAL A 96PHE A 105ARG A 174 | None | 0.88A | 4xr4B-1zbxA:undetectable | 4xr4B-1zbxA:19.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a3d | PROTEIN (DE NOVOTHREE-HELIX BUNDLE) (syntheticconstruct) |
no annotation | 3 | VAL A 53PHE A 38ARG A 10 | None | 0.92A | 4xr4B-2a3dA:undetectable | 4xr4B-2a3dA:11.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2avn | UBIQUINONE/MENAQUINONE BIOSYNTHESISMETHYLTRANSFERASE-RELATED PROTEIN (Thermotogamaritima) |
PF08241(Methyltransf_11) | 3 | VAL A 241PHE A 35ARG A 227 | None | 0.87A | 4xr4B-2avnA:3.2 | 4xr4B-2avnA:20.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b4i | OUTER CAPSID PROTEINVP4 (Rotavirus A) |
PF17477(Rota_VP4_MID) | 3 | VAL A 368PHE A 362ARG A 269 | None | 0.86A | 4xr4B-2b4iA:undetectable | 4xr4B-2b4iA:22.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c0k | HEMOGLOBIN (Gasterophilusintestinalis) |
PF00042(Globin) | 3 | VAL A 6PHE A 86ARG A 138 | None | 0.86A | 4xr4B-2c0kA:undetectable | 4xr4B-2c0kA:16.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cg9 | ATP-DEPENDENTMOLECULAR CHAPERONEHSP82 (Saccharomycescerevisiae) |
PF00183(HSP90)PF02518(HATPase_c) | 3 | VAL A 498PHE A 487ARG A 579 | None | 0.71A | 4xr4B-2cg9A:undetectable | 4xr4B-2cg9A:20.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d1c | ISOCITRATEDEHYDROGENASE (Thermusthermophilus) |
PF00180(Iso_dh) | 3 | VAL A 219PHE A 237ARG A 233 | None | 0.90A | 4xr4B-2d1cA:4.8 | 4xr4B-2d1cA:22.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f9q | CYTOCHROME P450 2D6 (Homo sapiens) |
PF00067(p450) | 3 | VAL A 104PHE A 120ARG A 441 | NoneHEM A 600 (-4.6A)HEM A 600 (-3.5A) | 0.97A | 4xr4B-2f9qA:undetectable | 4xr4B-2f9qA:21.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gk1 | BETA-HEXOSAMINIDASESUBUNIT BETA CHAIN A (Homo sapiens) |
no annotation | 3 | VAL N 443PHE N 409ARG N 435 | None | 0.95A | 4xr4B-2gk1N:undetectable | 4xr4B-2gk1N:18.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h1n | OLIGOENDOPEPTIDASE F (Geobacillusstearothermophilus) |
PF01432(Peptidase_M3) | 3 | VAL A 427PHE A 485ARG A 203 | None | 0.89A | 4xr4B-2h1nA:undetectable | 4xr4B-2h1nA:22.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hke | DIPHOSPHOMEVALONATEDECARBOXYLASE,PUTATIVE (Trypanosomabrucei) |
PF00288(GHMP_kinases_N) | 3 | VAL A 185PHE A 16ARG A 149 | None | 0.88A | 4xr4B-2hkeA:undetectable | 4xr4B-2hkeA:21.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2k06 | TRANSCRIPTIONANTITERMINATIONPROTEIN NUSG (Escherichiacoli) |
PF02357(NusG) | 3 | VAL A 11PHE A 65ARG A 114 | None | 0.94A | 4xr4B-2k06A:undetectable | 4xr4B-2k06A:14.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nmp | CYSTATHIONINEGAMMA-LYASE (Homo sapiens) |
PF01053(Cys_Met_Meta_PP) | 3 | VAL A 25PHE A 18ARG A 197 | None | 0.77A | 4xr4B-2nmpA:2.4 | 4xr4B-2nmpA:22.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2np0 | BOTULINUM NEUROTOXINTYPE B (Clostridiumbotulinum) |
PF01742(Peptidase_M27)PF07951(Toxin_R_bind_C)PF07952(Toxin_trans)PF07953(Toxin_R_bind_N) | 3 | VAL A 135PHE A 128ARG A 301 | None | 0.95A | 4xr4B-2np0A:undetectable | 4xr4B-2np0A:15.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2om6 | PROBABLEPHOSPHOSERINEPHOSPHATASE (Pyrococcushorikoshii) |
PF13419(HAD_2) | 3 | VAL A 65PHE A 126ARG A 48 | NoneNoneSO4 A1300 (-2.5A) | 0.64A | 4xr4B-2om6A:5.1 | 4xr4B-2om6A:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ox4 | PUTATIVE MANDELATERACEMASE (Zymomonasmobilis) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 3 | VAL A 167PHE A 233ARG A 201 | None | 0.98A | 4xr4B-2ox4A:undetectable | 4xr4B-2ox4A:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p5u | UDP-GLUCOSE4-EPIMERASE (Thermusthermophilus) |
PF01370(Epimerase) | 3 | VAL A 113PHE A 232ARG A 23 | None | 0.95A | 4xr4B-2p5uA:8.3 | 4xr4B-2p5uA:23.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2re3 | UNCHARACTERIZEDPROTEIN (Ruegeriapomeroyi) |
PF06938(DUF1285) | 3 | VAL A 80PHE A 36ARG A 76 | None | 0.90A | 4xr4B-2re3A:undetectable | 4xr4B-2re3A:18.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v4j | SULFITE REDUCTASE,DISSIMILATORY-TYPESUBUNIT ALPHASULFITE REDUCTASE,DISSIMILATORY-TYPESUBUNIT BETA (Desulfovibriovulgaris) |
PF01077(NIR_SIR)PF03460(NIR_SIR_ferr) | 3 | VAL A 80PHE A 153ARG B 17 | None | 0.95A | 4xr4B-2v4jA:undetectable | 4xr4B-2v4jA:23.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vc2 | INTEGRIN ALPHA-IIB (Homo sapiens) |
PF01839(FG-GAP)PF13517(VCBS) | 3 | VAL A 445PHE A 25ARG A 422 | None | 0.90A | 4xr4B-2vc2A:undetectable | 4xr4B-2vc2A:21.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a9f | CYTOCHROME C (Chlorobaculumtepidum) |
PF10643(Cytochrome-c551) | 3 | VAL A 148PHE A 165ARG A 166 | None | 0.92A | 4xr4B-3a9fA:undetectable | 4xr4B-3a9fA:16.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ahm | OLIGOPEPTIDASE (Geobacillus sp.MO-1) |
no annotation | 3 | VAL A 427PHE A 485ARG A 203 | None | 0.86A | 4xr4B-3ahmA:undetectable | 4xr4B-3ahmA:22.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3axi | OLIGO-1,6-GLUCOSIDASE IMA1 (Saccharomycescerevisiae) |
PF00128(Alpha-amylase) | 3 | VAL A 109PHE A 178ARG A 442 | NoneGLC A 601 (-3.4A)GLC A 601 (-2.9A) | 0.87A | 4xr4B-3axiA:undetectable | 4xr4B-3axiA:20.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b12 | FLUOROACETATEDEHALOGENASE (Burkholderiasp.) |
PF00561(Abhydrolase_1) | 3 | VAL A 143PHE A 136ARG A 108 | NoneNoneFAH A 501 (-4.1A) | 0.94A | 4xr4B-3b12A:3.7 | 4xr4B-3b12A:21.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bc8 | O-PHOSPHOSERYL-TRNA(SEC) SELENIUMTRANSFERASE (Mus musculus) |
PF05889(SepSecS) | 3 | VAL A 406PHE A 422ARG A 169 | None | 0.96A | 4xr4B-3bc8A:3.6 | 4xr4B-3bc8A:22.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bpv | TRANSCRIPTIONALREGULATOR (Methanothermobacterthermautotrophicus) |
PF01047(MarR) | 3 | VAL A 139PHE A 56ARG A 44 | None | 0.69A | 4xr4B-3bpvA:undetectable | 4xr4B-3bpvA:15.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gms | PUTATIVENADPH:QUINONEREDUCTASE (Bacillusthuringiensis) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 3 | VAL A 132PHE A 282ARG A 92 | None | 0.84A | 4xr4B-3gmsA:4.7 | 4xr4B-3gmsA:22.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gn3 | PUTATIVEPROTEIN-DISULFIDEISOMERASE (Pseudomonassyringae groupgenomosp. 3) |
PF13462(Thioredoxin_4) | 3 | VAL A 62PHE A 94ARG A 115 | None | 0.94A | 4xr4B-3gn3A:undetectable | 4xr4B-3gn3A:16.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hib | PRE-MRNA-SPLICINGHELICASE BRR2 (Saccharomycescerevisiae) |
PF02889(Sec63) | 3 | VAL A1926PHE A1943ARG A1895 | None | 0.95A | 4xr4B-3hibA:undetectable | 4xr4B-3hibA:21.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kza | BETA-LACTOGLOBULIN (Bos taurus;Equus caballus) |
PF00061(Lipocalin) | 3 | VAL A 123PHE A 136ARG A 148 | None | 0.93A | 4xr4B-3kzaA:undetectable | 4xr4B-3kzaA:16.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mlp | TRANSCRIPTION FACTORCOE1 (Mus musculus) |
PF01833(TIG)PF16422(COE1_DBD)PF16423(COE1_HLH) | 3 | VAL A 305PHE A 335ARG A 310 | None | 0.76A | 4xr4B-3mlpA:undetectable | 4xr4B-3mlpA:18.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mn8 | LP15968P (Drosophilamelanogaster) |
PF00246(Peptidase_M14)PF13620(CarboxypepD_reg) | 3 | VAL A 206PHE A 177ARG A 194 | None | 0.79A | 4xr4B-3mn8A:undetectable | 4xr4B-3mn8A:22.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nj2 | DUF269-CONTAININGPROTEIN (Cyanothece sp.ATCC 51142) |
PF03270(DUF269) | 3 | VAL A 112PHE A 142ARG A 88 | None | 0.88A | 4xr4B-3nj2A:undetectable | 4xr4B-3nj2A:16.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nsj | PERFORIN-1 (Mus musculus) |
PF00168(C2)PF01823(MACPF) | 3 | VAL A 481PHE A 518ARG A 498 | NoneNone CL A 720 (-3.9A) | 0.94A | 4xr4B-3nsjA:undetectable | 4xr4B-3nsjA:22.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nv9 | MALIC ENZYME (Entamoebahistolytica) |
PF00390(malic)PF03949(Malic_M) | 3 | VAL A 361PHE A 393ARG A 397 | None | 0.92A | 4xr4B-3nv9A:5.0 | 4xr4B-3nv9A:21.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o7o | ENDOGLUCANASE (Thermotogamaritima) |
PF01670(Glyco_hydro_12) | 3 | VAL A 134PHE A 224ARG A 200 | None | 0.97A | 4xr4B-3o7oA:undetectable | 4xr4B-3o7oA:22.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oa6 | MALE-SPECIFIC LETHAL3 HOMOLOG (Homo sapiens) |
PF11717(Tudor-knot) | 3 | VAL A 36PHE A 56ARG A 65 | NoneMLZ G 20 ( 3.8A)None | 0.84A | 4xr4B-3oa6A:undetectable | 4xr4B-3oa6A:11.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ob9 | MALE-SPECIFIC LETHAL3-LIKE 1(DROSOPHILA),ISOFORM CRA_C (Homo sapiens) |
PF11717(Tudor-knot) | 3 | VAL A 36PHE A 56ARG A 65 | NoneNHE A 540 (-3.5A)None | 0.98A | 4xr4B-3ob9A:undetectable | 4xr4B-3ob9A:12.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p3q | MMOQ (Methylococcuscapsulatus) |
PF08668(HDOD) | 3 | VAL A 89PHE A 104ARG A 70 | None | 0.68A | 4xr4B-3p3qA:undetectable | 4xr4B-3p3qA:23.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3phf | ENVELOPEGLYCOPROTEIN HENVELOPEGLYCOPROTEIN L (Humangammaherpesvirus4) |
no annotation | 3 | VAL B 120PHE A 211ARG A 71 | None | 0.93A | 4xr4B-3phfB:undetectable | 4xr4B-3phfB:13.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3psf | TRANSCRIPTIONELONGATION FACTORSPT6 (Saccharomycescerevisiae) |
PF14635(HHH_7)PF14639(YqgF)PF14641(HTH_44)PF14878(DLD) | 3 | VAL A 548PHE A 689ARG A 690 | None | 0.93A | 4xr4B-3psfA:undetectable | 4xr4B-3psfA:18.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rsc | CALG2 (Micromonosporaechinospora) |
PF04101(Glyco_tran_28_C) | 3 | VAL A 299PHE A 246ARG A 242 | NoneNonePO4 A 399 (-3.7A) | 0.87A | 4xr4B-3rscA:6.5 | 4xr4B-3rscA:23.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wic | GLUCOSE1-DEHYDROGENASE (Thermoplasmavolcanium) |
PF08240(ADH_N)PF16912(Glu_dehyd_C) | 3 | VAL A 250PHE A 168ARG A 208 | None | 0.85A | 4xr4B-3wicA:5.8 | 4xr4B-3wicA:20.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wy2 | ALPHA-GLUCOSIDASE (Halomonas sp.H11) |
PF00128(Alpha-amylase)PF11941(DUF3459) | 3 | VAL A 102PHE A 166ARG A 400 | NoneBGC A 605 ( 3.8A)BGC A 605 (-3.0A) | 0.83A | 4xr4B-3wy2A:undetectable | 4xr4B-3wy2A:23.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zuq | BOTULINUM NEUROTOXINTYPE B (Clostridiumbotulinum) |
PF01742(Peptidase_M27)PF07952(Toxin_trans) | 3 | VAL A 136PHE A 129ARG A 302 | None | 0.94A | 4xr4B-3zuqA:undetectable | 4xr4B-3zuqA:19.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aw2 | SERINE/THREONINE-PROTEIN KINASE MRCKALPHA (Rattusnorvegicus) |
PF00069(Pkinase)PF00433(Pkinase_C) | 3 | VAL A 130PHE A 402ARG A 123 | None | 0.97A | 4xr4B-4aw2A:undetectable | 4xr4B-4aw2A:21.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bwf | UBIQUITIN-CONJUGATING ENZYME E2-21 KDA (Saccharomycescerevisiae) |
PF00179(UQ_con) | 3 | VAL A 107PHE A 173ARG A 177 | NoneEDO A1180 (-4.8A)None | 0.93A | 4xr4B-4bwfA:undetectable | 4xr4B-4bwfA:16.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4czd | PUTATIVETRANSCRIPTIONALREGULATOR, ASNCFAMILY (Desulfovibriodesulfuricans) |
no annotation | 3 | VAL B 12PHE B 5ARG B 47 | None | 0.84A | 4xr4B-4czdB:undetectable | 4xr4B-4czdB:16.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g56 | MGC81050 PROTEIN (Xenopus laevis) |
PF00400(WD40) | 3 | VAL B 293PHE B 281ARG B 282 | None | 0.85A | 4xr4B-4g56B:undetectable | 4xr4B-4g56B:24.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hec | - (-) |
PF16473(DUF5051) | 3 | VAL A 2PHE A 5ARG A 155 | None | 0.87A | 4xr4B-4hecA:undetectable | 4xr4B-4hecA:17.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m0v | EXONUCLEASE SUBUNITSBCD (Escherichiacoli) |
PF00149(Metallophos)PF12320(SbcD_C) | 3 | VAL A 104PHE A 50ARG A 60 | NoneNoneGOL A 401 (-3.9A) | 0.94A | 4xr4B-4m0vA:undetectable | 4xr4B-4m0vA:22.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nh0 | CELLDIVISIONFTSK/SPOIIIE (Thermomonosporacurvata) |
PF01580(FtsK_SpoIIIE) | 3 | VAL A 527PHE A 518ARG A 490 | None | 0.88A | 4xr4B-4nh0A:undetectable | 4xr4B-4nh0A:18.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pn0 | MRNA-CAPPING ENZYMESUBUNIT BETA (Schizosaccharomycespombe) |
PF02940(mRNA_triPase) | 3 | VAL A 230PHE A 135ARG A 136 | None | 0.88A | 4xr4B-4pn0A:undetectable | 4xr4B-4pn0A:21.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pyz | UBIQUITINCARBOXYL-TERMINALHYDROLASE 7 (Homo sapiens) |
PF12436(USP7_ICP0_bdg) | 3 | VAL A 685PHE A 688ARG A 634 | None | 0.72A | 4xr4B-4pyzA:undetectable | 4xr4B-4pyzA:21.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qku | HYDROLASE (Burkholderiacenocepacia) |
PF01557(FAA_hydrolase)PF09298(FAA_hydrolase_N) | 3 | VAL A 57PHE A 36ARG A 97 | None | 0.94A | 4xr4B-4qkuA:undetectable | 4xr4B-4qkuA:24.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rf7 | ARGININE KINASE (Anthopleurajaponica) |
PF00217(ATP-gua_Ptrans)PF02807(ATP-gua_PtransN) | 3 | VAL A 556PHE A 544ARG A 585 | None | 0.92A | 4xr4B-4rf7A:undetectable | 4xr4B-4rf7A:20.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wph | UBIQUITINCARBOXYL-TERMINALHYDROLASE 7 (Homo sapiens) |
PF12436(USP7_ICP0_bdg) | 3 | VAL A 685PHE A 688ARG A 634 | None | 0.65A | 4xr4B-4wphA:undetectable | 4xr4B-4wphA:21.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yyf | BETA-N-ACETYLHEXOSAMINIDASE (Mycolicibacteriumsmegmatis) |
PF00933(Glyco_hydro_3) | 3 | VAL A 271PHE A 305ARG A 376 | None | 0.72A | 4xr4B-4yyfA:undetectable | 4xr4B-4yyfA:25.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z48 | UNCHARACTERIZEDPROTEIN (Desulfovibriopiger) |
PF17131(LolA_like) | 3 | VAL A 117PHE A 90ARG A 68 | NoneNoneIOD A 301 (-4.5A) | 0.98A | 4xr4B-4z48A:undetectable | 4xr4B-4z48A:18.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z96 | UBIQUITINCARBOXYL-TERMINALHYDROLASE 7 (Homo sapiens) |
PF12436(USP7_ICP0_bdg)PF14533(USP7_C2) | 3 | VAL A 685PHE A 688ARG A 634 | None | 0.66A | 4xr4B-4z96A:undetectable | 4xr4B-4z96A:22.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zdl | O-PHOSPHOSERYL-TRNA(SEC) SELENIUMTRANSFERASE (Homo sapiens) |
PF05889(SepSecS) | 3 | VAL A 406PHE A 422ARG A 169 | None | 0.95A | 4xr4B-4zdlA:3.5 | 4xr4B-4zdlA:23.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5aa5 | NIFE-HYDROGENASELARGE SUBUNIT, HOFGNIFE-HYDROGENASESMALL SUBUNIT, HOFK (Cupriavidusnecator) |
PF00374(NiFeSe_Hases)PF01058(Oxidored_q6)PF14720(NiFe_hyd_SSU_C) | 3 | VAL A 67PHE C 127ARG C 501 | NoneNoneNFU C 701 (-4.6A) | 0.80A | 4xr4B-5aa5A:undetectable | 4xr4B-5aa5A:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c6d | UBIQUITINCARBOXYL-TERMINALHYDROLASE 7 (Homo sapiens) |
PF12436(USP7_ICP0_bdg) | 3 | VAL A 685PHE A 688ARG A 634 | VAL A 685 ( 0.6A)PHE A 688 ( 1.3A)ARG A 634 ( 0.6A) | 0.71A | 4xr4B-5c6dA:undetectable | 4xr4B-5c6dA:20.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d04 | PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATEALDOLASE (Neisseriameningitidis) |
PF00793(DAHP_synth_1) | 3 | VAL C 260PHE C 187ARG C 175 | NoneNone CL C 402 (-2.9A) | 0.68A | 4xr4B-5d04C:undetectable | 4xr4B-5d04C:20.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5epo | 7-ALPHA-HYDROXYSTEROID DEYDROGENASE (Clostridiumsardiniense) |
PF13561(adh_short_C2) | 3 | VAL A 96PHE A 204ARG A 205 | NoneTUD A 302 (-4.8A)None | 0.97A | 4xr4B-5epoA:9.4 | 4xr4B-5epoA:20.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ew5 | COLICIN-E9 (Escherichiacoli) |
PF03515(Cloacin) | 3 | VAL A 317PHE A 498ARG A 502 | None | 0.95A | 4xr4B-5ew5A:undetectable | 4xr4B-5ew5A:21.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fku | DNA POLYMERASE IIISUBUNIT ALPHA (Escherichiacoli) |
PF01336(tRNA_anti-codon)PF02811(PHP)PF07733(DNA_pol3_alpha)PF14579(HHH_6) | 3 | VAL A 217PHE A 210ARG A 175 | None | 0.97A | 4xr4B-5fkuA:undetectable | 4xr4B-5fkuA:18.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j7t | UBIQUITINCARBOXYL-TERMINALHYDROLASE 7 (Homo sapiens) |
PF00443(UCH)PF12436(USP7_ICP0_bdg) | 3 | VAL A 685PHE A 688ARG A 634 | None | 0.66A | 4xr4B-5j7tA:undetectable | 4xr4B-5j7tA:20.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l7l | ELP3 FAMILY, ELP3FAMILY (Dehalococcoidesmccartyi) |
PF04055(Radical_SAM)PF16199(Radical_SAM_C) | 3 | VAL A 156PHE A 87ARG A 147 | None | 0.87A | 4xr4B-5l7lA:undetectable | 4xr4B-5l7lA:24.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5liv | CYTOCHROME P450CYP260A1,CYTOCHROMEP450 CYP260A1 (Sorangiumcellulosum) |
PF00067(p450) | 3 | VAL A 349PHE A 88ARG A 214 | None | 0.91A | 4xr4B-5livA:undetectable | 4xr4B-5livA:23.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mdn | DNA POLYMERASE (Pyrobaculumcalidifontis) |
PF00136(DNA_pol_B)PF03104(DNA_pol_B_exo1) | 3 | VAL A 105PHE A 42ARG A 96 | None | 0.92A | 4xr4B-5mdnA:undetectable | 4xr4B-5mdnA:22.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oet | GLUTATHIONESYNTHETASE-LIKEEFFECTOR 30(GPA-GSS30-APO) (Globoderapallida) |
no annotation | 3 | VAL B 246PHE B 249ARG B 263 | None | 0.91A | 4xr4B-5oetB:undetectable | 4xr4B-5oetB:10.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t2s | DDK KINASEREGULATORY SUBUNITDBF4,SERINE/THREONINE-PROTEIN KINASERAD53 (Saccharomycescerevisiae) |
PF00498(FHA)PF08630(Dfp1_Him1_M) | 3 | VAL A 335PHE A 271ARG A 249 | None | 0.93A | 4xr4B-5t2sA:undetectable | 4xr4B-5t2sA:18.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ti1 | FUMARYLACETOACETATEHYDROLASE (Paraburkholderiaxenovorans) |
PF01557(FAA_hydrolase)PF09298(FAA_hydrolase_N) | 3 | VAL A 58PHE A 36ARG A 101 | None | 0.95A | 4xr4B-5ti1A:undetectable | 4xr4B-5ti1A:22.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xbt | PROBABLETRANSCRIPTIONALREGULATOR (Pseudomonasaeruginosa) |
no annotation | 3 | VAL A 168PHE A 130ARG A 127 | NonePEG A 305 (-3.4A)PEG A 305 (-4.0A) | 0.63A | 4xr4B-5xbtA:undetectable | 4xr4B-5xbtA:10.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xfa | NAD-REDUCINGHYDROGENASE (Hydrogenophilusthermoluteolus) |
PF00374(NiFeSe_Hases)PF01058(Oxidored_q6) | 3 | VAL C 130PHE D 57ARG C 105 | None | 0.98A | 4xr4B-5xfaC:3.5 | 4xr4B-5xfaC:17.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c6l | V-TYPE PROTON ATPASESUBUNIT A, VACUOLARISOFORM (Saccharomycescerevisiae) |
no annotation | 3 | VAL A 216PHE A 151ARG A 270 | None | 0.90A | 4xr4B-6c6lA:undetectable | 4xr4B-6c6lA:11.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6dll | P-HYDROXYBENZOATEHYDROXYLASE (Pseudomonasputida) |
no annotation | 3 | VAL A 225PHE A 239ARG A 220 | None | 0.91A | 4xr4B-6dllA:2.7 | 4xr4B-6dllA:11.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6egt | GLYCOPROTEIN (Rift Valleyfeverphlebovirus) |
no annotation | 3 | VAL A 999PHE A 903ARG A 985 | None | 0.81A | 4xr4B-6egtA:undetectable | 4xr4B-6egtA:22.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fv4 | N-ACETYLGLUCOSAMINE-6-PHOSPHATEDEACETYLASE (Mycolicibacteriumsmegmatis) |
no annotation | 3 | VAL A 358PHE A 312ARG A 313 | None | 0.98A | 4xr4B-6fv4A:2.4 | 4xr4B-6fv4A:13.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6h25 | - (-) |
no annotation | 3 | VAL D 155PHE D 221ARG D 190 | None | 0.80A | 4xr4B-6h25D:undetectable | 4xr4B-6h25D:undetectable |