SIMILAR PATTERNS OF AMINO ACIDS FOR 4XP6_A_B40A601_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bbp BILIN BINDING
PROTEIN

(Pieris
brassicae) 		PF00061
(Lipocalin) 		4 ASP A 109
VAL A  15
ASP A  16
PHE A  18
 None
 1.22A 4xp6A-1bbpA:
undetectable		 4xp6A-1bbpA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ck7 PROTEIN (GELATINASE
A)

(Homo sapiens) 		PF00040
(fn2)
PF00045
(Hemopexin)
PF00413
(Peptidase_M10)
PF01471
(PG_binding_1) 		4 ASP A 564
VAL A 568
ASP A 569
GLY A 585
 None
 1.18A 4xp6A-1ck7A:
0.0		 4xp6A-1ck7A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)

(Hepacivirus C) 		PF02907
(Peptidase_S29)
PF07652
(Flavi_DEAD) 		4 ASP A 296
VAL A 456
ASP A 454
GLY A 484
 None
 1.18A 4xp6A-1cu1A:
0.0		 4xp6A-1cu1A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gkp HYDANTOINASE

(Thermus sp.) 		PF01979
(Amidohydro_1) 		4 ASP A 131
VAL A 161
ASP A 162
GLY A 164
 None
 1.19A 4xp6A-1gkpA:
0.1		 4xp6A-1gkpA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iv0 HYPOTHETICAL PROTEIN

(Thermus
thermophilus) 		PF03652
(RuvX) 		4 ASP A  39
VAL A   8
ASP A   7
GLY A  14
 None
 1.19A 4xp6A-1iv0A:
undetectable		 4xp6A-1iv0A:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jxi PHOSPHOMETHYLPYRIMID
INE KINASE

(Salmonella
enterica) 		PF08543
(Phos_pyr_kin) 		4 ASP A  13
VAL A 107
ASP A 105
GLY A 212
 None
HMH  A2001 ( 4.7A)
SO4  A2003 (-2.9A)
SO4  A2003 (-3.2A)
 1.09A 4xp6A-1jxiA:
0.0		 4xp6A-1jxiA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n0s BILIN-BINDING
PROTEIN

(Pieris
brassicae) 		PF00061
(Lipocalin) 		4 ASP A 164
VAL A  61
ASP A  60
GLY A  43
 None
 1.19A 4xp6A-1n0sA:
undetectable		 4xp6A-1n0sA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o75 47 KDA MEMBRANE
ANTIGEN

(Treponema
pallidum) 		PF14888
(PBP-Tp47_c)
PF14889
(PBP-Tp47_a) 		4 ASP A  46
ASP A 228
PHE A 305
GLY A 301
 None
 1.23A 4xp6A-1o75A:
undetectable		 4xp6A-1o75A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1se8 SINGLE-STRAND
BINDING PROTEIN

(Deinococcus
radiodurans) 		PF00436
(SSB) 		4 ASP A  17
VAL A 123
ASP A 118
GLY A 121
 None
 1.21A 4xp6A-1se8A:
undetectable		 4xp6A-1se8A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sef CONSERVED
HYPOTHETICAL PROTEIN

(Enterococcus
faecalis) 		PF05899
(Cupin_3)
PF07883
(Cupin_2) 		4 ASP A 257
ASP A  64
PHE A 232
GLY A 206
 None
 1.24A 4xp6A-1sefA:
undetectable		 4xp6A-1sefA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sfr ANTIGEN 85-A

(Mycobacterium
tuberculosis) 		PF00756
(Esterase) 		4 VAL A  72
ASP A  40
PHE A  48
GLY A  50
 None
 1.26A 4xp6A-1sfrA:
0.0		 4xp6A-1sfrA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tp7 GENOME POLYPROTEIN

(Rhinovirus A) 		PF00680
(RdRP_1) 		4 ASP A 357
ASP A 366
PHE A 377
GLY A 368
 None
DMX  A 500 (-4.1A)
None
DMX  A 500 ( 4.7A)
 1.23A 4xp6A-1tp7A:
0.0		 4xp6A-1tp7A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ttu LIN-12 AND GLP-1
TRANSCRIPTIONAL
REGULATOR

(Caenorhabditis
elegans) 		PF01833
(TIG)
PF09270
(BTD)
PF09271
(LAG1-DNAbind) 		4 VAL A 461
ASP A 459
PHE A 220
GLY A 423
 EDO  A  51 (-4.6A)
None
EDO  A  53 (-3.9A)
EDO  A  53 ( 3.9A)
 0.91A 4xp6A-1ttuA:
0.0		 4xp6A-1ttuA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tuz DIACYLGLYCEROL
KINASE ALPHA

(Homo sapiens) 		PF14513
(DAG_kinase_N) 		4 ASP A  98
VAL A  93
ASP A  92
GLY A  81
 None
 1.18A 4xp6A-1tuzA:
undetectable		 4xp6A-1tuzA:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ub0 PHOSPHOMETHYLPYRIMID
INE KINASE

(Thermus
thermophilus) 		PF08543
(Phos_pyr_kin) 		4 ASP A  11
VAL A 105
ASP A 103
GLY A 209
 None
 0.97A 4xp6A-1ub0A:
0.0		 4xp6A-1ub0A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uqx LECTIN

(Ralstonia
solanacearum) 		PF07472
(PA-IIL) 		4 VAL A  32
ASP A  33
PHE A  14
GLY A  60
 None
 1.22A 4xp6A-1uqxA:
undetectable		 4xp6A-1uqxA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uso HEPATOCYTE NUCLEAR
FACTOR 1-ALPHA

(Thermus
thermophilus) 		PF01329
(Pterin_4a) 		4 ASP A  26
VAL A  46
PHE A  21
GLY A  49
 None
 1.02A 4xp6A-1usoA:
undetectable		 4xp6A-1usoA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zxu AT5G01750 PROTEIN

(Arabidopsis
thaliana) 		PF04525
(LOR) 		4 ASP A 145
VAL A 168
PHE A 199
GLY A  25
 None
 1.23A 4xp6A-1zxuA:
undetectable		 4xp6A-1zxuA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2boi CV-IIL LECTIN

(Chromobacterium
violaceum) 		PF07472
(PA-IIL) 		4 VAL A  32
ASP A  33
PHE A  14
GLY A  60
 None
 1.19A 4xp6A-2boiA:
undetectable		 4xp6A-2boiA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dep THERMOSTABLE
CELLOXYLANASE

([Clostridium]
stercorarium) 		PF00331
(Glyco_hydro_10) 		4 ASP A 230
VAL A 246
PHE A 282
GLY A 258
 None
 1.06A 4xp6A-2depA:
undetectable		 4xp6A-2depA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dph FORMALDEHYDE
DISMUTASE

(Pseudomonas
putida) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ASP A  48
VAL A  58
PHE A  56
GLY A  54
 None
 1.09A 4xp6A-2dphA:
undetectable		 4xp6A-2dphA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f8q ALKALINE
THERMOSTABLE
ENDOXYLANASE

(Bacillus sp.
NG-27) 		PF00331
(Glyco_hydro_10) 		4 ASP A 196
VAL A 212
PHE A 248
GLY A 224
 None
 1.00A 4xp6A-2f8qA:
undetectable		 4xp6A-2f8qA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fon PEROXISOMAL ACYL-COA
OXIDASE 1A

(Solanum
lycopersicum) 		PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N) 		4 ASP A   9
VAL A   4
ASP A 622
GLY A 623
 None
 1.23A 4xp6A-2fonA:
undetectable		 4xp6A-2fonA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g3n ALPHA-GLUCOSIDASE

(Sulfolobus
solfataricus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 ASP A 347
VAL A  86
ASP A  87
GLY A  89
 None
None
BOG  A2000 (-2.7A)
BOG  A2000 ( 4.2A)
 1.21A 4xp6A-2g3nA:
undetectable		 4xp6A-2g3nA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5b PHOSPHOMETHYLPYRIMID
INE KINASE

(Bacillus
subtilis) 		PF08543
(Phos_pyr_kin) 		4 ASP A  13
VAL A 109
ASP A 107
GLY A 215
 None
None
None
ADP  A 301 (-3.2A)
 0.90A 4xp6A-2i5bA:
undetectable		 4xp6A-2i5bA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jky HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE

(Saccharomyces
cerevisiae) 		PF00156
(Pribosyltran) 		4 ASP A  71
VAL A 112
ASP A 110
GLY A  39
 None
5GP  A 300 (-4.9A)
5GP  A 300 (-3.4A)
None
 1.03A 4xp6A-2jkyA:
undetectable		 4xp6A-2jkyA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k23 LIPOCALIN 2

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		4 ASP A 146
VAL A 153
PHE A 168
GLY A  35
 None
 1.01A 4xp6A-2k23A:
undetectable		 4xp6A-2k23A:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k3d LIN0334 PROTEIN

(Listeria
innocua) 		PF07252
(DUF1433) 		4 ASP A  50
VAL A  21
PHE A  70
GLY A  64
 None
 1.04A 4xp6A-2k3dA:
undetectable		 4xp6A-2k3dA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q2r GLUCOKINASE 1,
PUTATIVE

(Trypanosoma
cruzi) 		PF02685
(Glucokinase) 		4 ASP A  61
VAL A  30
PHE A 104
GLY A  32
 None
 1.10A 4xp6A-2q2rA:
undetectable		 4xp6A-2q2rA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qf7 PYRUVATE CARBOXYLASE
PROTEIN

(Rhizobium etli) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ASP A 655
VAL A 636
ASP A 633
GLY A 953
 None
 1.20A 4xp6A-2qf7A:
undetectable		 4xp6A-2qf7A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uwf ALKALINE ACTIVE
ENDOXYLANASE

(Bacillus
halodurans) 		PF00331
(Glyco_hydro_10) 		4 ASP A 202
VAL A 218
PHE A 254
GLY A 230
 None
 1.09A 4xp6A-2uwfA:
undetectable		 4xp6A-2uwfA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wjf TYROSINE-PROTEIN
PHOSPHATASE CPSB

(Streptococcus
pneumoniae) 		no annotation 4 VAL A  12
ASP A  13
PHE A  10
GLY A  15
 None
 1.23A 4xp6A-2wjfA:
undetectable		 4xp6A-2wjfA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Pseudomonas
aeruginosa) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 ASP A  54
ASP A 106
PHE A  84
GLY A  82
 None
 1.16A 4xp6A-2x3eA:
undetectable		 4xp6A-2x3eA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yg1 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Heterobasidion
annosum) 		PF00840
(Glyco_hydro_7) 		4 ASP A 335
VAL A 231
ASP A 257
GLY A 260
 None
 1.02A 4xp6A-2yg1A:
undetectable		 4xp6A-2yg1A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zzg ALANYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF01411
(tRNA-synt_2c)
PF07973
(tRNA_SAD) 		4 ASP A 103
VAL A  94
ASP A  93
GLY A 195
 None
 0.98A 4xp6A-2zzgA:
undetectable		 4xp6A-2zzgA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3p METHYLTRANSFERASE

(Geobacter
sulfurreducens) 		PF01596
(Methyltransf_3) 		4 ASP A 134
VAL A  39
ASP A  40
GLY A 199
 None
 1.25A 4xp6A-3c3pA:
undetectable		 4xp6A-3c3pA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN
RESPIRATORY NITRATE
REDUCTASE 1 BETA
CHAIN

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF13247
(Fer4_11)
PF14710
(Nitr_red_alph_N)
PF14711
(Nitr_red_bet_C) 		4 ASP B 146
VAL A1149
ASP A1131
GLY B 150
 None
 1.13A 4xp6A-3egwB:
undetectable		 4xp6A-3egwB:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f41 PHYTASE

(Mitsuokella
multacida) 		PF14566
(PTPlike_phytase) 		4 ASP A 289
VAL A 262
ASP A 265
PHE A 275
 None
None
None
EDO  A   5 (-3.8A)
 0.99A 4xp6A-3f41A:
0.0		 4xp6A-3f41A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g20 TYPE II SECRETION
PROTEIN

(Escherichia
coli) 		PF08334
(T2SSG) 		4 ASP A  29
VAL A  36
ASP A  92
GLY A 115
 None
None
None
CA  A 201 ( 4.8A)
 1.26A 4xp6A-3g20A:
undetectable		 4xp6A-3g20A:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gc3 BETA-ARRESTIN-1

(Bos taurus) 		PF00339
(Arrestin_N)
PF02752
(Arrestin_C) 		4 ASP A  26
VAL A  37
ASP A  38
GLY A  23
 None
 1.16A 4xp6A-3gc3A:
undetectable		 4xp6A-3gc3A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gnq GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE, TYPE
I

(Burkholderia
pseudomallei) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 ASP A  39
VAL A  76
ASP A  65
GLY A  64
 None
 1.24A 4xp6A-3gnqA:
undetectable		 4xp6A-3gnqA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hj6 FRUCTOKINASE

(Halothermothrix
orenii) 		PF00294
(PfkB) 		4 VAL A 111
ASP A  33
PHE A 153
GLY A  55
 None
 1.20A 4xp6A-3hj6A:
undetectable		 4xp6A-3hj6A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE

(Sulfurisphaera
tokodaii) 		PF00128
(Alpha-amylase)
PF09196
(DUF1953) 		4 ASP A  71
VAL A 216
ASP A 217
GLY A  79
 None
 1.26A 4xp6A-3hjeA:
0.0		 4xp6A-3hjeA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i58 O-METHYLTRANSFERASE

(Streptomyces
carzinostaticus) 		PF00891
(Methyltransf_2) 		4 ASP A 147
VAL A 198
ASP A 175
GLY A 177
 None
None
SAH  A 401 ( 4.2A)
SAH  A 401 (-3.9A)
 1.16A 4xp6A-3i58A:
undetectable		 4xp6A-3i58A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l49 ABC SUGAR (RIBOSE)
TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
SUBUNIT

(Rhodobacter
sphaeroides) 		PF13407
(Peripla_BP_4) 		4 ASP A  42
ASP A  73
PHE A 160
GLY A  96
 None
None
UNL  A   1 ( 4.4A)
None
 1.11A 4xp6A-3l49A:
undetectable		 4xp6A-3l49A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ld1 REPLICASE
POLYPROTEIN 1A

(Avian
coronavirus) 		no annotation 4 ASP A  45
VAL A  11
PHE A  54
GLY A  51
 None
 1.20A 4xp6A-3ld1A:
undetectable		 4xp6A-3ld1A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lfr PUTATIVE METAL ION
TRANSPORTER

(Pseudomonas
syringae group
genomosp. 3) 		PF00571
(CBS) 		4 ASP A 106
ASP A 165
PHE A 139
GLY A 168
 None
 1.25A 4xp6A-3lfrA:
undetectable		 4xp6A-3lfrA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2

(Dichelobacter
nodosus) 		PF00082
(Peptidase_S8) 		4 ASP A  82
VAL A 258
ASP A 259
GLY A 261
 None
 1.24A 4xp6A-3lpdA:
undetectable		 4xp6A-3lpdA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxg ADAPTER PROTEIN MECA
1
NEGATIVE REGULATOR
OF GENETIC
COMPETENCE CLPC/MECB

(Bacillus
subtilis) 		PF00004
(AAA)
PF02151
(UVR)
PF02861
(Clp_N) 		4 ASP A 428
VAL a 139
ASP a 138
GLY a 134
 None
 1.19A 4xp6A-3pxgA:
undetectable		 4xp6A-3pxgA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20

(Saccharomyces
cerevisiae) 		PF03070
(TENA_THI-4)
PF08543
(Phos_pyr_kin) 		4 ASP A  33
VAL A 128
ASP A 126
GLY A 242
 None
SO4  A   1 (-3.5A)
SO4  A   1 (-2.8A)
SO4  A   1 (-3.3A)
 0.98A 4xp6A-3rm5A:
undetectable		 4xp6A-3rm5A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rqi RESPONSE REGULATOR
PROTEIN

(Burkholderia
pseudomallei) 		PF00072
(Response_reg)
PF02954
(HTH_8) 		4 ASP A  11
VAL A   8
PHE A  15
GLY A  17
 CIT  A 182 ( 2.5A)
None
None
None
 1.26A 4xp6A-3rqiA:
undetectable		 4xp6A-3rqiA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8k UNCHARACTERIZED
PROTEIN

(Leptotrichia
buccalis) 		no annotation 4 ASP A  29
VAL A   7
PHE A  23
GLY A  26
 None
 1.20A 4xp6A-3t8kA:
undetectable		 4xp6A-3t8kA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uor ABC TRANSPORTER
SUGAR BINDING
PROTEIN

(Xanthomonas
citri) 		PF13416
(SBP_bac_8) 		4 ASP A 211
VAL A 407
ASP A 408
PHE A 216
 None
 1.06A 4xp6A-3uorA:
undetectable		 4xp6A-3uorA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aur LEOA

(Escherichia
coli) 		PF00350
(Dynamin_N) 		4 ASP A  38
VAL A 277
ASP A 276
GLY A 274
 None
 1.19A 4xp6A-4aurA:
undetectable		 4xp6A-4aurA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4axn CHITINASE C1

(Serratia
marcescens) 		PF00704
(Glyco_hydro_18) 		4 VAL A  99
ASP A 134
PHE A  85
GLY A 132
 None
CA  A1329 (-2.9A)
None
CA  A1329 (-3.9A)
 1.12A 4xp6A-4axnA:
undetectable		 4xp6A-4axnA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c5n PHOSPHOMETHYLPYRIMID
INE KINASE

(Staphylococcus
aureus) 		PF08543
(Phos_pyr_kin) 		4 ASP A  13
VAL A 107
ASP A 105
GLY A 213
 PXL  A 300 (-4.3A)
None
None
ACP  A 500 (-3.3A)
 0.86A 4xp6A-4c5nA:
undetectable		 4xp6A-4c5nA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ehi BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Campylobacter
jejuni) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		4 VAL A 489
ASP A 486
PHE A 460
GLY A 481
 None
 1.15A 4xp6A-4ehiA:
undetectable		 4xp6A-4ehiA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ft6 PROBABLE PORIN

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		4 ASP A 271
VAL A 166
ASP A 167
GLY A 168
 None
 1.24A 4xp6A-4ft6A:
undetectable		 4xp6A-4ft6A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1s 5'-NUCLEOTIDASE

(Homo sapiens) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		4 ASP A 121
ASP A 524
PHE A 500
GLY A 419
 None
 1.21A 4xp6A-4h1sA:
undetectable		 4xp6A-4h1sA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iru LEPB

(Legionella
pneumophila) 		no annotation 4 ASP A 361
VAL A 496
ASP A 493
GLY A 491
 None
 1.25A 4xp6A-4iruA:
undetectable		 4xp6A-4iruA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0e PROBABLE
3-HYDROXYACYL-COA
DEHYDROGENASE
F54C8.1

(Caenorhabditis
elegans) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 ASP A 291
VAL A 280
ASP A 251
GLY A 249
 None
 1.26A 4xp6A-4j0eA:
undetectable		 4xp6A-4j0eA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j2q S-ARRESTIN

(Bos taurus) 		PF00339
(Arrestin_N)
PF02752
(Arrestin_C) 		4 ASP A  30
VAL A  41
ASP A  42
GLY A  27
 None
 1.14A 4xp6A-4j2qA:
undetectable		 4xp6A-4j2qA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jel CMP/HYDROXYMETHYL
CMP HYDROLASE

(Streptomyces
rimofaciens) 		PF05014
(Nuc_deoxyrib_tr) 		4 VAL A  87
ASP A  86
PHE A  48
GLY A  14
 None
 1.25A 4xp6A-4jelA:
undetectable		 4xp6A-4jelA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jw1 EFFECTOR PROTEIN B

(Legionella
pneumophila) 		no annotation 4 ASP A 361
VAL A 496
ASP A 493
GLY A 491
 None
 1.24A 4xp6A-4jw1A:
undetectable		 4xp6A-4jw1A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jx6 PYRUVATE CARBOXYLASE

(Rhizobium etli) 		PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		4 ASP A 655
VAL A 636
ASP A 633
GLY A 953
 None
 1.17A 4xp6A-4jx6A:
undetectable		 4xp6A-4jx6A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m29 BETA-XYLOSIDASE

(Caulobacter
vibrioides) 		PF01229
(Glyco_hydro_39) 		4 ASP A 466
VAL A 491
ASP A 490
GLY A 433
 None
 1.13A 4xp6A-4m29A:
undetectable		 4xp6A-4m29A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mx3 CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-ALPHA REGULATORY
SUBUNIT

(Bos taurus) 		PF00027
(cNMP_binding) 		4 ASP A 288
VAL A 281
PHE A 291
GLY A 323
 None
None
None
CMP  A 402 (-3.5A)
 0.98A 4xp6A-4mx3A:
undetectable		 4xp6A-4mx3A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n9w GDP-MANNOSE-DEPENDEN
T
ALPHA-(1-2)-PHOSPHAT
IDYLINOSITOL
MANNOSYLTRANSFERASE

(Mycolicibacterium
smegmatis) 		PF13439
(Glyco_transf_4)
PF13692
(Glyco_trans_1_4) 		4 ASP A 232
ASP A 198
PHE A 247
GLY A 229
 None
 1.24A 4xp6A-4n9wA:
undetectable		 4xp6A-4n9wA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nvs PUTATIVE ENZYME,
GLYOXALASE FAMILY

(Clostridioides
difficile) 		PF12681
(Glyoxalase_2) 		4 ASP A 110
ASP A  67
PHE A  63
GLY A  65
 None
 1.20A 4xp6A-4nvsA:
undetectable		 4xp6A-4nvsA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4om9 SERINE PROTEASE PET

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		4 ASP A 169
VAL A 568
ASP A 522
GLY A 626
 None
 1.25A 4xp6A-4om9A:
undetectable		 4xp6A-4om9A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pue ENDO-1,4-BETA-XYLANA
SE

(Geobacillus
stearothermophilus) 		PF00331
(Glyco_hydro_10) 		4 ASP A 202
VAL A 218
PHE A 254
GLY A 230
 None
 1.05A 4xp6A-4pueA:
undetectable		 4xp6A-4pueA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qdd 3-KETOSTEROID
9ALPHA-HYDROXYLASE
OXYGENASE

(Rhodococcus
rhodochrous) 		PF00355
(Rieske) 		4 ASP A 247
VAL A 304
PHE A 300
GLY A 279
 30Q  A 403 (-3.7A)
30Q  A 403 ( 3.9A)
30Q  A 403 (-3.6A)
None
 1.21A 4xp6A-4qddA:
undetectable		 4xp6A-4qddA:
20.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster) 		PF00209
(SNF) 		4 ASP A  46
VAL A 120
ASP A 121
GLY A 425
 41U  A 605 ( 3.3A)
41U  A 605 (-4.2A)
41U  A 605 ( 4.2A)
41U  A 605 ( 3.7A)
 0.23A 4xp6A-4xnuA:
62.3		 4xp6A-4xnuA:
98.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster) 		PF00209
(SNF) 		4 ASP A  46
VAL A 120
PHE A 325
GLY A 425
 41U  A 605 ( 3.3A)
41U  A 605 (-4.2A)
41U  A 605 ( 4.7A)
41U  A 605 ( 3.7A)
 0.80A 4xp6A-4xnuA:
62.3		 4xp6A-4xnuA:
98.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xx6 BETA-XYLANASE

(Gloeophyllum
trabeum) 		PF00331
(Glyco_hydro_10) 		4 ASP A 203
VAL A 220
PHE A 254
GLY A 231
 None
 1.24A 4xp6A-4xx6A:
undetectable		 4xp6A-4xx6A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awm STRESS-ACTIVATED
PROTEIN KINASE JNK

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		4 ASP A 270
ASP A 281
PHE A 278
GLY A 276
 None
 1.14A 4xp6A-5awmA:
undetectable		 4xp6A-5awmA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b4s CHITOSANASE

(Mitsuaria
chitosanitabida) 		PF13647
(Glyco_hydro_80) 		4 ASP A  20
VAL A 181
PHE A 193
GLY A 200
 None
 1.24A 4xp6A-5b4sA:
0.0		 4xp6A-5b4sA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b6k UNCHARACTERIZED
PROTEIN CGKR1

([Candida]
glabrata) 		PF01370
(Epimerase) 		4 ASP A 336
VAL A 207
PHE A 280
GLY A 278
 None
 1.22A 4xp6A-5b6kA:
undetectable		 4xp6A-5b6kA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cw6 DRBRCC36

(Danio rerio) 		PF01398
(JAB) 		4 ASP A  37
VAL A  88
ASP A 116
GLY A 118
 None
 1.21A 4xp6A-5cw6A:
undetectable		 4xp6A-5cw6A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax) 		PF00027
(cNMP_binding)
PF00069
(Pkinase) 		4 ASP A 204
VAL A 197
PHE A 207
GLY A 233
 None
 1.17A 4xp6A-5ezrA:
undetectable		 4xp6A-5ezrA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fwx GLUTAMATE RECEPTOR 4

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		4 ASP B 245
ASP B 225
PHE B 356
GLY B 222
 None
 1.08A 4xp6A-5fwxB:
undetectable		 4xp6A-5fwxB:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gt5 PECTATE LYASE

(Paenibacillus
sp. 0602) 		no annotation 4 VAL A 177
ASP A 178
PHE A 193
GLY A 246
 None
 1.08A 4xp6A-5gt5A:
undetectable		 4xp6A-5gt5A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5guf CDP-ARCHAEOL
SYNTHASE

(Aeropyrum
pernix) 		no annotation 4 ASP A 100
VAL A  40
ASP A  41
GLY A  54
 CTP  A 201 ( 3.4A)
None
None
None
 1.20A 4xp6A-5gufA:
0.1		 4xp6A-5gufA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5haf DEUBIQUITINASE SSEL

(Salmonella
enterica) 		no annotation 4 ASP A  67
ASP A  80
PHE A  33
GLY A  75
 None
 1.12A 4xp6A-5hafA:
undetectable		 4xp6A-5hafA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hj7 GLUTAMATE RACEMASE

(Mycobacterium
tuberculosis) 		PF01177
(Asp_Glu_race) 		4 ASP A  61
VAL A  94
PHE A  11
GLY A   9
 None
 1.23A 4xp6A-5hj7A:
undetectable		 4xp6A-5hj7A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjt SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5

(Arabidopsis
thaliana) 		PF00149
(Metallophos)
PF00515
(TPR_1)
PF08321
(PPP5)
PF13431
(TPR_17) 		4 VAL A 259
ASP A 257
PHE A 321
GLY A 288
 None
NI  A 501 ( 3.1A)
None
None
 1.26A 4xp6A-5jjtA:
0.0		 4xp6A-5jjtA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jr7 CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-ALPHA REGULATORY
SUBUNIT

(Bos taurus) 		PF00027
(cNMP_binding) 		4 ASP B 288
VAL B 281
PHE B 291
GLY B 323
 None
 1.04A 4xp6A-5jr7B:
undetectable		 4xp6A-5jr7B:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jrl DIPEPTIDYL
AMINOPEPTIDASES/ACYL
AMINOACYL-PEPTIDASES
-LIKE PROTEIN

(Sphingopyxis
alaskensis) 		PF00326
(Peptidase_S9) 		4 ASP A 227
ASP A 161
PHE A 246
GLY A 235
 None
 1.18A 4xp6A-5jrlA:
undetectable		 4xp6A-5jrlA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2p ARYLESTERASE

(Sulfolobus
solfataricus) 		PF07859
(Abhydrolase_3) 		4 ASP A 223
VAL A 210
ASP A 211
GLY A 213
 None
 1.25A 4xp6A-5l2pA:
0.0		 4xp6A-5l2pA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l8s AMINO ACYL PEPTIDASE

(Sporosarcina
psychrophila) 		PF00326
(Peptidase_S9) 		4 VAL A 422
ASP A 425
PHE A 408
GLY A 429
 None
 1.19A 4xp6A-5l8sA:
undetectable		 4xp6A-5l8sA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t3b GLYCOSIDE HYDROLASE

(Bacteroides
plebeius) 		no annotation 4 VAL A 154
ASP A 151
PHE A 107
GLY A 146
 None
 1.25A 4xp6A-5t3bA:
undetectable		 4xp6A-5t3bA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t81 EPOB

(Sorangium
cellulosum) 		PF00668
(Condensation) 		4 ASP A 276
VAL A 466
PHE A 470
GLY A 468
 None
 1.26A 4xp6A-5t81A:
undetectable		 4xp6A-5t81A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tv1 BETA-ARRESTIN-2

(Bos taurus) 		no annotation 4 ASP A  27
VAL A  38
ASP A  39
GLY A  24
 None
 1.08A 4xp6A-5tv1A:
undetectable		 4xp6A-5tv1A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uki RNA LARIAT
DEBRANCHING ENZYME,
PUTATIVE

(Entamoeba
histolytica) 		no annotation 4 ASP A 137
ASP A 181
PHE A 155
GLY A 131
 None
 0.84A 4xp6A-5ukiA:
undetectable		 4xp6A-5ukiA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vpq BETA-LACTAMASE

(Paraburkholderia
phymatum) 		PF13354
(Beta-lactamase2) 		4 ASP A 270
VAL A 222
ASP A 224
GLY A 207
 None
 1.05A 4xp6A-5vpqA:
undetectable		 4xp6A-5vpqA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis) 		no annotation 4 ASP A 459
VAL A 425
ASP A 426
GLY A 408
 None
 1.00A 4xp6A-5xwyA:
0.0		 4xp6A-5xwyA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z9x SMALL RNA DEGRADING
NUCLEASE 1

(Arabidopsis
thaliana) 		no annotation 4 ASP A 183
VAL A 158
ASP A 195
GLY A 190
 None
 1.05A 4xp6A-5z9xA:
undetectable		 4xp6A-5z9xA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6l V-TYPE PROTON ATPASE
SUBUNIT C'
V-TYPE PROTON ATPASE
SUBUNIT D

(Saccharomyces
cerevisiae) 		no annotation 4 ASP B 298
VAL D 122
ASP D 121
GLY D  44
 None
 1.13A 4xp6A-6c6lB:
undetectable		 4xp6A-6c6lB:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhe -

(-) 		no annotation 4 ASP A 196
VAL A 214
PHE A 250
GLY A 226
 None
 1.13A 4xp6A-6fheA:
undetectable		 4xp6A-6fheA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gup -

(-) 		no annotation 4 ASP A 293
VAL A 288
PHE A 281
GLY A 283
 None
 1.10A 4xp6A-6gupA:
undetectable		 4xp6A-6gupA:
undetectable