SIMILAR PATTERNS OF AMINO ACIDS FOR 4XP3_A_DX4A401

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fw1 GLUTATHIONE
TRANSFERASE ZETA

(Homo sapiens) 		PF13417
(GST_N_3)
PF14497
(GST_C_3) 		4 ALA A  23
LYS A  27
LEU A 164
MET A 161
 None
 1.18A 4xp3A-1fw1A:
undetectable		 4xp3A-1fw1A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7q ANTHRANILATE
SYNTHASE

(Serratia
marcescens) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		4 ALA A 195
GLN A 194
LEU A  11
LEU A   8
 None
 1.28A 4xp3A-1i7qA:
undetectable		 4xp3A-1i7qA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iy9 SPERMIDINE SYNTHASE

(Bacillus
subtilis) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 ALA A 179
GLN A 149
LEU A 180
LEU A  81
 None
 1.08A 4xp3A-1iy9A:
undetectable		 4xp3A-1iy9A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j4j TABTOXIN RESISTANCE
PROTEIN

(Pseudomonas
amygdali) 		PF13673
(Acetyltransf_10) 		4 ALA A  88
GLN A  89
LEU A 107
MET A 108
 None
None
ACO  A 301 (-3.9A)
None
 1.25A 4xp3A-1j4jA:
undetectable		 4xp3A-1j4jA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j4j TABTOXIN RESISTANCE
PROTEIN

(Pseudomonas
amygdali) 		PF13673
(Acetyltransf_10) 		4 ALA A  88
LEU A 107
MET A 108
LEU A  35
 None
ACO  A 301 (-3.9A)
None
None
 1.09A 4xp3A-1j4jA:
undetectable		 4xp3A-1j4jA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jyh DNA GYRASE
INHIBITORY PROTEIN

(Escherichia
coli) 		PF06445
(GyrI-like) 		4 ALA A 151
LEU A 126
MET A 125
LEU A 117
 None
 1.21A 4xp3A-1jyhA:
undetectable		 4xp3A-1jyhA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1o REPLICATION PROTEIN
A 70 KDA DNA-BINDING
SUBUNIT

(Homo sapiens) 		PF08646
(Rep_fac-A_C) 		4 ALA C 536
GLN C 533
LEU C 516
LEU C 547
 None
 1.20A 4xp3A-1l1oC:
undetectable		 4xp3A-1l1oC:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qpi PROTEIN
(TETRACYCLINE
REPRESSOR)

(Escherichia
coli) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		4 ALA A  31
GLN A  32
LEU A  34
LEU A  16
 None
 1.26A 4xp3A-1qpiA:
undetectable		 4xp3A-1qpiA:
21.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1v0b CELL DIVISION
CONTROL PROTEIN 2
HOMOLOG

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		4 ALA A 168
LEU A 172
MET A 173
LEU A 231
 None
 1.22A 4xp3A-1v0bA:
29.1		 4xp3A-1v0bA:
36.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w36 EXODEOXYRIBONUCLEASE
V GAMMA CHAIN

(Escherichia
coli) 		PF04257
(Exonuc_V_gamma) 		4 ALA C 928
GLN C 925
LEU C 927
LEU C 884
 None
 1.06A 4xp3A-1w36C:
undetectable		 4xp3A-1w36C:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6m CONSERVED
HYPOTHETICAL PROTEIN

(Enterococcus
faecalis) 		PF13462
(Thioredoxin_4) 		4 ALA A  91
GLN A  90
LEU A  95
LEU A 123
 None
 1.25A 4xp3A-1z6mA:
undetectable		 4xp3A-1z6mA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bz0 GTP CYCLOHYDROLASE
II

(Escherichia
coli) 		PF00925
(GTP_cyclohydro2) 		4 ALA A  74
GLN A  77
LEU A  86
LEU A  47
 None
 1.25A 4xp3A-2bz0A:
undetectable		 4xp3A-2bz0A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkl TRINUCLEOTIDE REPEAT
CONTAINING 6C
PROTEIN

(Homo sapiens) 		PF00627
(UBA) 		4 ALA A  38
LEU A  56
MET A  53
LEU A  49
 None
 1.20A 4xp3A-2dklA:
undetectable		 4xp3A-2dklA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dyl DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A 163
LEU A 214
MET A 215
LEU A 266
 None
 0.66A 4xp3A-2dylA:
23.5		 4xp3A-2dylA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f37 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 2

(Homo sapiens) 		PF12796
(Ank_2) 		4 ALA A 236
GLN A 234
LEU A 213
LEU A 167
 None
 1.22A 4xp3A-2f37A:
undetectable		 4xp3A-2f37A:
22.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 ALA A  40
GLN A  93
LEU A  95
MET A  96
LEU A 144
 ADP  A 500 ( 3.7A)
ADP  A 500 (-3.8A)
ADP  A 500 ( 4.9A)
None
ADP  A 500 (-4.3A)
 0.57A 4xp3A-2f9gA:
41.0		 4xp3A-2f9gA:
50.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fym ENOLASE

(Escherichia
coli) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 ALA A 122
LYS A 125
LEU A 129
LEU A 136
 None
 1.26A 4xp3A-2fymA:
undetectable		 4xp3A-2fymA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqf HYPOTHETICAL PROTEIN
HI0933

(Haemophilus
influenzae) 		PF03486
(HI0933_like) 		4 ALA A  21
LYS A  25
GLN A  22
LEU A  86
 None
 0.92A 4xp3A-2gqfA:
undetectable		 4xp3A-2gqfA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2izw RYEGRASS MOTTLE
VIRUS COAT PROTEIN

(Ryegrass mottle
virus) 		PF00729
(Viral_coat) 		4 ALA A 202
LEU A 137
MET A 136
LEU A 170
 None
 1.19A 4xp3A-2izwA:
undetectable		 4xp3A-2izwA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jok PUTATIVE
G-NUCLEOTIDE
EXCHANGE FACTOR

(Burkholderia
pseudomallei) 		PF07487
(SopE_GEF) 		4 ALA A  84
GLN A  83
LEU A 193
LEU A 202
 None
 1.16A 4xp3A-2jokA:
undetectable		 4xp3A-2jokA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mc3 MUS81 ENDONUCLEASE
HOMOLOG (YEAST),
ISOFORM CRA_B

(Homo sapiens) 		no annotation 4 ALA A  90
GLN A  87
LEU A  16
LEU A  23
 None
 1.20A 4xp3A-2mc3A:
undetectable		 4xp3A-2mc3A:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 ALA A 319
LEU A 433
MET A 430
LEU A 426
 None
 1.18A 4xp3A-2p54A:
undetectable		 4xp3A-2p54A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		4 ALA A  46
LEU A 105
MET A 106
LEU A 156
 ATP  A 381 (-3.5A)
None
None
ATP  A 381 ( 4.8A)
 0.28A 4xp3A-2phkA:
26.4		 4xp3A-2phkA:
29.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 ALA A 176
LEU A 180
MET A 181
LEU A 239
 None
 1.19A 4xp3A-2pmiA:
27.2		 4xp3A-2pmiA:
33.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pop MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE
7-INTERACTING
PROTEIN 1

(Homo sapiens) 		PF00481
(PP2C) 		4 ALA A 188
GLN A 202
LEU A 287
MET A 288
 None
 1.26A 4xp3A-2popA:
undetectable		 4xp3A-2popA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qb0 TELSAM DOMAIN -
LYSOZYME CHIMERA

(Escherichia
virus T4) 		PF00959
(Phage_lysozyme)
PF02198
(SAM_PNT) 		4 ALA B  35
GLN B  36
LEU B  38
LEU B  22
 None
 1.08A 4xp3A-2qb0B:
undetectable		 4xp3A-2qb0B:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qs9 RETINOBLASTOMA-BINDI
NG PROTEIN 9

(Homo sapiens) 		PF06821
(Ser_hydrolase) 		4 ALA A  98
GLN A 146
LEU A  95
LEU A 157
 None
 1.24A 4xp3A-2qs9A:
undetectable		 4xp3A-2qs9A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r2w PLASMINOGEN
ACTIVATOR, UROKINASE

(Homo sapiens) 		PF00089
(Trypsin) 		4 ALA U 112
GLN U 113
LEU U  68
MET U  81
 None
 1.27A 4xp3A-2r2wU:
undetectable		 4xp3A-2r2wU:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ALA A 749
LEU A 798
MET A 799
LEU A 850
 GW7  A   1 (-3.3A)
GW7  A   1 (-4.5A)
None
GW7  A   1 (-4.2A)
 0.50A 4xp3A-2r4bA:
21.3		 4xp3A-2r4bA:
24.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wnt RIBOSOMAL PROTEIN S6
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A 445
LEU A 491
MET A 492
LEU A 542
 None
 0.90A 4xp3A-2wntA:
16.3		 4xp3A-2wntA:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xk9 CHECKPOINT KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A 247
LEU A 303
MET A 304
LEU A 354
 XK9  A1511 ( 4.1A)
XK9  A1511 (-4.1A)
None
XK9  A1511 (-4.6A)
 0.19A 4xp3A-2xk9A:
23.7		 4xp3A-2xk9A:
31.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsx BETA-ENOLASE

(Homo sapiens) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 ALA A 123
LYS A 126
LEU A 130
LEU A 137
 None
 1.22A 4xp3A-2xsxA:
undetectable		 4xp3A-2xsxA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A  51
LEU A 109
MET A 110
LEU A 160
 B49  A1294 (-3.2A)
B49  A1294 ( 4.7A)
None
B49  A1294 (-4.4A)
 0.25A 4xp3A-2y7jA:
27.7		 4xp3A-2y7jA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zpa UNCHARACTERIZED
PROTEIN YPFI

(Escherichia
coli) 		PF05127
(Helicase_RecD)
PF08351
(DUF1726)
PF13718
(GNAT_acetyltr_2)
PF17176
(tRNA_bind_3) 		4 ALA A 646
GLN A 647
LEU A 649
LEU A 609
 None
 1.26A 4xp3A-2zpaA:
undetectable		 4xp3A-2zpaA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zzs CYTOCHROME C554

(Vibrio
parahaemolyticus) 		no annotation 4 ALA A  31
GLN A  28
LEU A  95
LEU A 102
 None
None
HEC  A 220 ( 3.8A)
None
 1.22A 4xp3A-2zzsA:
undetectable		 4xp3A-2zzsA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9y AMMONIUM TRANSPORTER
FAMILY RH-LIKE
PROTEIN

(Nitrosomonas
europaea) 		PF00909
(Ammonium_transp) 		4 ALA A 135
LEU A 134
MET A 119
LEU A 116
 None
 1.18A 4xp3A-3b9yA:
undetectable		 4xp3A-3b9yA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bb8 CDP-4-KETO-6-DEOXY-D
-GLUCOSE-3-DEHYDRASE

(Yersinia
pseudotuberculosis) 		PF01041
(DegT_DnrJ_EryC1) 		4 ALA A 301
GLN A 302
LEU A  48
MET A  49
 None
 1.05A 4xp3A-3bb8A:
undetectable		 4xp3A-3bb8A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clh 3-DEHYDROQUINATE
SYNTHASE

(Helicobacter
pylori) 		PF01761
(DHQ_synthase) 		4 ALA A 123
GLN A 124
LEU A 122
LEU A 163
 NAD  A 400 ( 4.6A)
None
NAD  A 400 (-3.7A)
NAD  A 400 (-4.7A)
 1.17A 4xp3A-3clhA:
undetectable		 4xp3A-3clhA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvq PEROXISOME TARGETING
SIGNAL 1 RECEPTOR
PEX5

(Trypanosoma
brucei) 		PF13432
(TPR_16) 		4 ALA A 500
GLN A 501
LEU A 529
LEU A 536
 None
 1.10A 4xp3A-3cvqA:
undetectable		 4xp3A-3cvqA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d5f PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 ALA A 328
LEU A 442
MET A 439
LEU A 435
 None
 1.14A 4xp3A-3d5fA:
undetectable		 4xp3A-3d5fA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fme DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A  80
LEU A 131
MET A 132
LEU A 186
 STU  A   1 (-3.4A)
STU  A   1 (-4.6A)
None
STU  A   1 (-4.4A)
 0.30A 4xp3A-3fmeA:
21.0		 4xp3A-3fmeA:
26.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gqp HEMOGLOBIN SUBUNIT
ALPHA

(Felis catus) 		PF00042
(Globin) 		4 ALA A  69
GLN A  68
LEU A  76
LEU A  83
 None
None
None
HEM  A 143 ( 4.4A)
 1.02A 4xp3A-3gqpA:
undetectable		 4xp3A-3gqpA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdj PROBABLE ORNITHINE
CYCLODEAMINASE

(Bordetella
pertussis) 		PF02423
(OCD_Mu_crystall) 		4 ALA A  24
GLN A  59
LEU A  27
LEU A 288
 IMD  A 317 (-3.6A)
IMD  A 317 (-3.5A)
None
None
 1.25A 4xp3A-3hdjA:
undetectable		 4xp3A-3hdjA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hs0 COBRA VENOM FACTOR

(Naja kaouthia) 		PF01759
(NTR)
PF07677
(A2M_recep) 		4 ALA C1340
LYS C1338
LEU C1341
MET C1342
 None
 1.18A 4xp3A-3hs0C:
undetectable		 4xp3A-3hs0C:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6u SERINE/THREONINE-PRO
TEIN KINASE CHK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00498
(FHA) 		4 ALA A 247
LEU A 303
MET A 304
LEU A 354
 None
 0.69A 4xp3A-3i6uA:
23.4		 4xp3A-3i6uA:
26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ij5 3-DEOXY-D-MANNO-OCTU
LOSONATE 8-PHOSPHATE
PHOSPHATASE

(Yersinia pestis) 		PF08282
(Hydrolase_3) 		4 ALA A  22
GLN A 176
LEU A 171
LEU A  64
 None
 1.22A 4xp3A-3ij5A:
undetectable		 4xp3A-3ij5A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ij6 UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE

(Lactobacillus
acidophilus) 		PF04909
(Amidohydro_2) 		4 ALA A 226
LYS A 230
GLN A 227
LEU A 221
 None
 1.15A 4xp3A-3ij6A:
undetectable		 4xp3A-3ij6A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3juj UDP-GLUCOSE
PYROPHOSPHORYLASE
(GALU)

(Helicobacter
pylori) 		PF00483
(NTP_transferase) 		4 ALA A 129
LEU A  35
MET A  27
LEU A  62
 None
 0.98A 4xp3A-3jujA:
undetectable		 4xp3A-3jujA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k0z PUTATIVE POLYKETIDE
CYCLASE

(Bacillus cereus) 		PF07366
(SnoaL) 		4 ALA A  52
LYS A  28
GLN A  49
LEU A  47
 None
 1.00A 4xp3A-3k0zA:
undetectable		 4xp3A-3k0zA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l12 PUTATIVE
GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Ruegeria
pomeroyi) 		PF03009
(GDPD) 		4 ALA A 239
GLN A 238
LEU A 236
LEU A 268
 None
 1.26A 4xp3A-3l12A:
undetectable		 4xp3A-3l12A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ALA A 719
LEU A 768
MET A 769
LEU A 820
 ITI  A   1 (-2.9A)
ITI  A   1 (-4.8A)
ITI  A   1 (-4.8A)
ITI  A   1 (-4.6A)
 0.81A 4xp3A-3lzbA:
21.0		 4xp3A-3lzbA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		4 ALA A 213
LEU A 265
MET A 266
LEU A 318
 AMP  A 577 (-3.4A)
AMP  A 577 ( 4.9A)
None
AMP  A 577 (-4.8A)
 0.39A 4xp3A-3nyoA:
27.5		 4xp3A-3nyoA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE

(Escherichia
coli) 		PF03738
(GSP_synth)
PF05257
(CHAP) 		4 ALA A 531
LYS A 533
GLN A 568
LEU A 570
 ADP  A3001 (-3.6A)
ADP  A3001 (-2.8A)
ADP  A3001 (-4.0A)
ADP  A3001 (-4.3A)
 1.02A 4xp3A-3o98A:
undetectable		 4xp3A-3o98A:
21.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pg1 MITOGEN-ACTIVATED
PROTEIN KINASE,
PUTATIVE (MAP
KINASE-LIKE PROTEIN)

(Leishmania
major) 		PF00069
(Pkinase) 		4 ALA A  49
LEU A 114
MET A 115
LEU A 165
 None
 0.91A 4xp3A-3pg1A:
32.3		 4xp3A-3pg1A:
39.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ALA A 751
LEU A 800
MET A 801
LEU A 852
 03Q  A   1 (-3.1A)
03Q  A   1 (-4.6A)
None
03Q  A   1 (-4.4A)
 0.44A 4xp3A-3pp0A:
22.7		 4xp3A-3pp0A:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rg2 ENTEROBACTIN
SYNTHASE COMPONENT E
(ENTE),
2,3-DIHYDRO-2,3-DIHY
DROXYBENZOATE
SYNTHETASE,
ISOCHROISMATASE
(ENTB)

(Escherichia
coli) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF13193
(AMP-binding_C) 		4 ALA A 126
GLN A  79
LEU A 154
LEU A 132
 None
 1.25A 4xp3A-3rg2A:
undetectable		 4xp3A-3rg2A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sbq NITROUS-OXIDE
REDUCTASE

(Pseudomonas
stutzeri) 		no annotation 4 ALA A 451
GLN A 472
LEU A 449
LEU A 425
 None
 1.22A 4xp3A-3sbqA:
undetectable		 4xp3A-3sbqA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sv0 CASEIN KINASE I-LIKE

(Oryza sativa) 		PF00069
(Pkinase) 		4 ALA A  36
LYS A  38
LEU A  84
LEU A 135
 None
 0.89A 4xp3A-3sv0A:
18.1		 4xp3A-3sv0A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swv BREFELDIN
A-INHIBITED GUANINE
NUCLEOTIDE-EXCHANGE
PROTEIN 2

(Homo sapiens) 		PF01369
(Sec7) 		4 ALA A 679
GLN A 680
LEU A 682
LEU A 671
 None
 1.22A 4xp3A-3swvA:
undetectable		 4xp3A-3swvA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vn9 DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A  80
LEU A 131
MET A 132
LEU A 186
 ANK  A 401 (-3.0A)
None
None
ANK  A 401 ( 4.9A)
 0.41A 4xp3A-3vn9A:
21.5		 4xp3A-3vn9A:
25.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w04 DWARF 88 ESTERASE

(Oryza sativa) 		PF12697
(Abhydrolase_6) 		4 ALA A 308
GLN A 309
LEU A 311
LEU A 292
 None
 1.17A 4xp3A-3w04A:
undetectable		 4xp3A-3w04A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ALA A1978
LEU A2028
MET A2029
LEU A2086
 VGH  A3000 (-3.4A)
VGH  A3000 ( 4.8A)
None
VGH  A3000 (-4.3A)
 0.29A 4xp3A-3zbfA:
23.4		 4xp3A-3zbfA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgq INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 5

(Homo sapiens) 		PF07719
(TPR_2)
PF13181
(TPR_8)
PF13374
(TPR_10)
PF13424
(TPR_12) 		4 ALA A  77
GLN A  76
LEU A  51
LEU A  42
 None
 1.18A 4xp3A-3zgqA:
undetectable		 4xp3A-3zgqA:
20.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A  82
LEU A 139
MET A 140
LEU A 189
 R4L  A1394 ( 3.7A)
R4L  A1394 ( 4.9A)
None
R4L  A1394 (-4.5A)
 0.54A 4xp3A-4b99A:
38.7		 4xp3A-4b99A:
46.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4be9 STEROL ESTERASE

(Ophiostoma
piceae) 		PF00135
(COesterase) 		4 ALA A  41
GLN A  42
LEU A 109
LEU A  48
 None
 0.95A 4xp3A-4be9A:
undetectable		 4xp3A-4be9A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bvu PROTEIN KINASE OSPG

(Shigella
flexneri) 		no annotation 4 ALA A  84
LEU A  99
MET A  98
LEU A  96
 None
 1.26A 4xp3A-4bvuA:
7.8		 4xp3A-4bvuA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE

(Lucilia cuprina) 		PF00135
(COesterase) 		4 ALA A  64
GLN A  65
LEU A 112
LEU A  71
 None
 1.22A 4xp3A-4fnmA:
undetectable		 4xp3A-4fnmA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ALA A1148
LEU A1198
MET A1199
LEU A1256
 0UV  A1501 (-3.4A)
0UV  A1501 ( 4.8A)
None
0UV  A1501 (-4.6A)
 0.21A 4xp3A-4fodA:
22.2		 4xp3A-4fodA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzw 2,3-DEHYDROADIPYL-CO
A HYDRATASE

(Escherichia
coli) 		PF00378
(ECH_1) 		4 ALA A 168
GLN A 170
LEU A 173
LEU A 152
 None
 1.01A 4xp3A-4fzwA:
undetectable		 4xp3A-4fzwA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h6w N-TERMINAL
CYANOBACTIN PROTEASE

(Planktothrix
agardhii) 		PF00082
(Peptidase_S8) 		4 GLN A 196
LEU A 273
MET A 274
LEU A 255
 None
 1.23A 4xp3A-4h6wA:
undetectable		 4xp3A-4h6wA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ka8 OLIGOPEPTIDASE A

(Arabidopsis
thaliana) 		PF01432
(Peptidase_M3) 		4 ALA A 719
GLN A 605
LEU A 722
LEU A 778
 None
GOL  A 803 (-4.9A)
GOL  A 805 ( 4.8A)
None
 1.00A 4xp3A-4ka8A:
undetectable		 4xp3A-4ka8A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4llr TRYPAREDOXIN
PEROXIDASE

(Trypanosoma
cruzi) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		4 ALA A  12
GLN A 137
LEU A 139
LEU A  39
 None
 0.74A 4xp3A-4llrA:
undetectable		 4xp3A-4llrA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mbg CAAX
FARNESYLTRANSFERASE
ALPHA SUBUNIT RAM2

(Aspergillus
fumigatus) 		PF01239
(PPTA) 		4 ALA A 257
GLN A 256
LEU A 219
LEU A 206
 None
 1.22A 4xp3A-4mbgA:
undetectable		 4xp3A-4mbgA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00169
(PH)
PF00615
(RGS) 		4 ALA A 218
LEU A 273
MET A 274
LEU A 324
 29X  A 702 (-3.1A)
29X  A 702 (-4.6A)
None
29X  A 702 (-4.6A)
 0.42A 4xp3A-4mk0A:
26.5		 4xp3A-4mk0A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mxw LYMPHOTOXIN-BETA

(Homo sapiens) 		no annotation 4 ALA Y 126
GLN Y 118
LEU Y 127
LEU Y 113
 None
 0.93A 4xp3A-4mxwY:
undetectable		 4xp3A-4mxwY:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pqj PHOSPHATE BINDING
PROTEIN

(Pseudomonas
aeruginosa) 		PF12849
(PBP_like_2) 		4 ALA A 286
LYS A 290
GLN A 287
LEU A 281
 None
 1.15A 4xp3A-4pqjA:
undetectable		 4xp3A-4pqjA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q5h PROTEIN KINASE OSPG

(Shigella sonnei) 		no annotation 4 ALA A  84
LEU A  99
MET A  98
LEU A  96
 None
None
ANP  A 202 (-3.7A)
None
 1.26A 4xp3A-4q5hA:
5.4		 4xp3A-4q5hA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qtb MITOGEN-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  69
GLN A 122
LEU A 124
MET A 125
LEU A 173
 38Z  A 418 (-3.4A)
38Z  A 418 (-3.7A)
38Z  A 418 ( 4.8A)
None
38Z  A 418 (-4.4A)
 0.32A 4xp3A-4qtbA:
50.5		 4xp3A-4qtbA:
85.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8p TALIN-1
AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER
1-INTERACTING
PROTEIN

(Mus musculus;
Mus musculus) 		no annotation
no annotation 		4 ALA A1529
LEU B  22
MET B  19
LEU B  15
 None
EDO  A1702 ( 4.7A)
EDO  A1701 (-3.8A)
EDO  A1701 ( 4.8A)
 1.19A 4xp3A-4w8pA:
undetectable		 4xp3A-4w8pA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 ALA A 428
LYS A 430
MET A 477
LEU A 528
 None
 0.37A 4xp3A-4xi2A:
22.0		 4xp3A-4xi2A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xii CHOLINESTERASE

(Homo sapiens) 		PF00135
(COesterase) 		4 ALA A  34
GLN A  35
LEU A  93
LEU A  41
 None
 0.99A 4xp3A-4xiiA:
undetectable		 4xp3A-4xiiA:
21.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xrl MITOGEN-ACTIVATED
PROTEIN KINASE 1

(Rattus
norvegicus) 		PF00069
(Pkinase) 		5 ALA A  50
GLN A 103
LEU A 105
MET A 106
LEU A 154
 42A  A 402 (-3.2A)
42A  A 402 (-3.9A)
42A  A 402 ( 4.9A)
None
42A  A 402 ( 4.9A)
 0.24A 4xp3A-4xrlA:
51.8		 4xp3A-4xrlA:
99.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zo4 DEPHOSPHO-COA KINASE

(Campylobacter
jejuni) 		PF01121
(CoaE) 		4 ALA A 154
LEU A 150
MET A 145
LEU A 141
 None
 1.16A 4xp3A-4zo4A:
undetectable		 4xp3A-4zo4A:
21.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4zsl MITOGEN-ACTIVATED
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A  82
LEU A 139
MET A 140
LEU A 189
 None
 0.42A 4xp3A-4zslA:
38.4		 4xp3A-4zslA:
48.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c6u AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF12897
(Aminotran_MocR) 		4 ALA A 319
GLN A 316
LEU A 226
LEU A 228
 None
 1.09A 4xp3A-5c6uA:
undetectable		 4xp3A-5c6uA:
22.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		4 ALA A  90
LEU A 146
MET A 147
LEU A 196
 None
 0.30A 4xp3A-5ci6A:
38.3		 4xp3A-5ci6A:
49.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g06 EXOSOME COMPLEX
COMPONENT RRP4

(Saccharomyces
cerevisiae) 		PF14382
(ECR1_N)
PF15985
(KH_6) 		4 ALA H 301
LYS H 305
LEU H 233
MET H 198
 None
 1.17A 4xp3A-5g06H:
undetectable		 4xp3A-5g06H:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8g CREB-BINDING PROTEIN

(Homo sapiens) 		PF00439
(Bromodomain)
PF06001
(DUF902) 		4 ALA A1093
GLN A1092
LEU A1094
MET A1095
 None
None
None
PEG  A1413 ( 4.2A)
 1.27A 4xp3A-5i8gA:
undetectable		 4xp3A-5i8gA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ALA A 743
LEU A 792
MET A 793
LEU A 844
 6HJ  A1101 (-3.1A)
6HJ  A1101 ( 4.9A)
None
6HJ  A1101 ( 4.8A)
 0.24A 4xp3A-5j9zA:
22.7		 4xp3A-5j9zA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kk5 CRISPR-ASSOCIATED
ENDONUCLEASE CPF1

(Acidaminococcus
sp. BV3L6) 		no annotation 4 ALA A 449
GLN A 452
LEU A 450
LEU A 454
 None
 1.13A 4xp3A-5kk5A:
undetectable		 4xp3A-5kk5A:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2r FUMARATE HYDRATASE

(Leishmania
major) 		PF05681
(Fumerase)
PF05683
(Fumerase_C) 		4 ALA A 371
GLN A 372
LEU A 374
LEU A  95
 None
 1.19A 4xp3A-5l2rA:
undetectable		 4xp3A-5l2rA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5med ARACHIDONATE
15-LIPOXYGENASE

(Cyanothece sp.
PCC 8801) 		PF00305
(Lipoxygenase) 		4 ALA A 152
LYS A 147
GLN A 155
LEU A 158
 None
 1.13A 4xp3A-5medA:
undetectable		 4xp3A-5medA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mmj 30S RIBOSOMAL
PROTEIN 3,
CHLOROPLASTIC

(Spinacia
oleracea) 		no annotation 4 ALA w 163
GLN w 162
LEU w 112
LEU w 114
 None
 1.26A 4xp3A-5mmjw:
undetectable		 4xp3A-5mmjw:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		4 ALA A 218
LEU A 273
MET A 274
LEU A 324
 QRW  A 601 (-3.4A)
None
MES  A 604 (-3.9A)
None
 0.39A 4xp3A-5uuuA:
26.3		 4xp3A-5uuuA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ydj ACETYLCHOLINESTERASE

(Anopheles
gambiae) 		no annotation 4 ALA A 197
GLN A 198
LEU A 256
LEU A 204
 None
 1.14A 4xp3A-5ydjA:
undetectable		 4xp3A-5ydjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yq3 AT3G55470

(Arabidopsis
thaliana) 		no annotation 4 ALA A  61
GLN A 138
LEU A   6
LEU A 136
 None
 1.11A 4xp3A-5yq3A:
undetectable		 4xp3A-5yq3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6arx ACETYLCHOLINESTERASE

(Anopheles
gambiae) 		no annotation 4 ALA A 197
GLN A 198
LEU A 256
LEU A 204
 None
 0.93A 4xp3A-6arxA:
undetectable		 4xp3A-6arxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cc2 CELL DIVISION
CONTROL PROTEIN 45
CDC45 PUTATIVE

(Entamoeba
histolytica) 		no annotation 4 ALA A 451
GLN A 452
LEU A 454
LEU A 407
 None
None
None
CL  A 614 ( 4.9A)
 1.27A 4xp3A-6cc2A:
undetectable		 4xp3A-6cc2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 4 ALA A 217
LEU A 266
MET A 267
LEU A 319
 FKY  A9001 (-3.3A)
FKY  A9001 (-4.4A)
None
FKY  A9001 ( 4.9A)
 0.31A 4xp3A-6cz4A:
21.6		 4xp3A-6cz4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gu8 -

(-) 		no annotation 4 ALA A 329
LEU A 332
MET A 333
LEU A 338
 None
 1.05A 4xp3A-6gu8A:
undetectable		 4xp3A-6gu8A:
undetectable