SIMILAR PATTERNS OF AMINO ACIDS FOR 4XOY_A_DX4A401

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fw1 GLUTATHIONE
TRANSFERASE ZETA

(Homo sapiens) 		PF13417
(GST_N_3)
PF14497
(GST_C_3) 		4 ALA A  23
LYS A  27
LEU A 164
MET A 161
 None
 1.18A 4xoyA-1fw1A:
undetectable		 4xoyA-1fw1A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE

(Escherichia
coli) 		PF00982
(Glyco_transf_20) 		4 ALA A 372
LEU A 431
MET A 430
LEU A 394
 None
 1.15A 4xoyA-1gz5A:
undetectable		 4xoyA-1gz5A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7q ANTHRANILATE
SYNTHASE

(Serratia
marcescens) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		4 ALA A 195
GLN A 194
LEU A  11
LEU A   8
 None
 1.19A 4xoyA-1i7qA:
undetectable		 4xoyA-1i7qA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j4j TABTOXIN RESISTANCE
PROTEIN

(Pseudomonas
amygdali) 		PF13673
(Acetyltransf_10) 		4 ALA A  88
LEU A 107
MET A 108
LEU A  35
 None
ACO  A 301 (-3.9A)
None
None
 1.05A 4xoyA-1j4jA:
undetectable		 4xoyA-1j4jA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1o REPLICATION PROTEIN
A 70 KDA DNA-BINDING
SUBUNIT

(Homo sapiens) 		PF08646
(Rep_fac-A_C) 		4 ALA C 536
GLN C 533
LEU C 516
LEU C 547
 None
 1.14A 4xoyA-1l1oC:
undetectable		 4xoyA-1l1oC:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nav HORMONE RECEPTOR
ALPHA 1, THRA1

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 ALA A 317
GLN A 320
LEU A 318
LEU A 236
 None
 1.18A 4xoyA-1navA:
undetectable		 4xoyA-1navA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qpi PROTEIN
(TETRACYCLINE
REPRESSOR)

(Escherichia
coli) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		4 ALA A  31
GLN A  32
LEU A  34
LEU A  16
 None
 1.19A 4xoyA-1qpiA:
undetectable		 4xoyA-1qpiA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tuo PUTATIVE
PHOSPHOMANNOMUTASE

(Thermus
thermophilus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 ALA A  65
LEU A 106
MET A 105
LEU A  91
 None
 0.93A 4xoyA-1tuoA:
undetectable		 4xoyA-1tuoA:
21.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ua2 CELL DIVISION
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A  39
LYS A  41
MET A  94
LEU A 144
 ATP  A 381 (-3.6A)
ATP  A 381 (-2.9A)
None
None
 0.59A 4xoyA-1ua2A:
11.4		 4xoyA-1ua2A:
35.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w36 EXODEOXYRIBONUCLEASE
V GAMMA CHAIN

(Escherichia
coli) 		PF04257
(Exonuc_V_gamma) 		4 ALA C 928
GLN C 925
LEU C 927
LEU C 884
 None
 1.07A 4xoyA-1w36C:
undetectable		 4xoyA-1w36C:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wxx HYPOTHETICAL PROTEIN
TTHA1280

(Thermus
thermophilus) 		PF10672
(Methyltrans_SAM) 		4 ALA A  77
GLN A  78
LEU A  80
LEU A 105
 None
 1.07A 4xoyA-1wxxA:
undetectable		 4xoyA-1wxxA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xls ORPHAN NUCLEAR
RECEPTOR NR1I3

(Mus musculus) 		PF00104
(Hormone_recep) 		4 ALA E 299
GLN E 295
LEU E 302
LEU E 326
 None
 1.18A 4xoyA-1xlsE:
undetectable		 4xoyA-1xlsE:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ac5 MAP
KINASE-INTERACTING
SERINE/THREONINE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A 360
GLN A 361
LEU A 363
LEU A 278
 None
 1.10A 4xoyA-2ac5A:
20.9		 4xoyA-2ac5A:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dyl DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A 163
LEU A 214
MET A 215
LEU A 266
 None
 0.55A 4xoyA-2dylA:
10.8		 4xoyA-2dylA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eta TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 2

(Rattus
norvegicus) 		PF12796
(Ank_2) 		4 ALA A 188
GLN A 235
LEU A 183
LEU A 229
 None
 1.09A 4xoyA-2etaA:
undetectable		 4xoyA-2etaA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f1n CYTOLETHAL
DISTENDING TOXIN
SUBUNIT B

(Escherichia
coli) 		PF03372
(Exo_endo_phos) 		4 ALA A 135
GLN A  43
LEU A 122
LEU A 100
 None
 1.18A 4xoyA-2f1nA:
undetectable		 4xoyA-2f1nA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f37 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 2

(Homo sapiens) 		PF12796
(Ank_2) 		4 ALA A 236
GLN A 234
LEU A 213
LEU A 167
 None
 1.17A 4xoyA-2f37A:
undetectable		 4xoyA-2f37A:
22.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 ALA A  40
GLN A  93
LEU A  95
MET A  96
LEU A 144
 ADP  A 500 ( 3.7A)
ADP  A 500 (-3.8A)
ADP  A 500 ( 4.9A)
None
ADP  A 500 (-4.3A)
 0.66A 4xoyA-2f9gA:
15.1		 4xoyA-2f9gA:
50.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqf HYPOTHETICAL PROTEIN
HI0933

(Haemophilus
influenzae) 		PF03486
(HI0933_like) 		4 ALA A  21
LYS A  25
GLN A  22
LEU A  86
 None
 0.90A 4xoyA-2gqfA:
undetectable		 4xoyA-2gqfA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8r HEPATOCYTE NUCLEAR
FACTOR 1-BETA

(Homo sapiens) 		PF00046
(Homeobox)
PF04814
(HNF-1_N) 		4 ALA A 167
GLN A 163
LEU A 168
LEU A 114
 None
 1.13A 4xoyA-2h8rA:
undetectable		 4xoyA-2h8rA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hw6 MAP
KINASE-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A 325
GLN A 326
LEU A 328
LEU A 243
 None
 1.10A 4xoyA-2hw6A:
21.1		 4xoyA-2hw6A:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jok PUTATIVE
G-NUCLEOTIDE
EXCHANGE FACTOR

(Burkholderia
pseudomallei) 		PF07487
(SopE_GEF) 		4 ALA A  84
GLN A  83
LEU A 193
LEU A 202
 None
 1.16A 4xoyA-2jokA:
undetectable		 4xoyA-2jokA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oqt HYPOTHETICAL PROTEIN
SPY0176

(Streptococcus
pyogenes) 		PF00359
(PTS_EIIA_2) 		4 ALA A   6
GLN A   5
LEU A   3
LEU A 142
 None
 1.17A 4xoyA-2oqtA:
undetectable		 4xoyA-2oqtA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 ALA A 319
LEU A 433
MET A 430
LEU A 426
 None
 1.18A 4xoyA-2p54A:
undetectable		 4xoyA-2p54A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		4 ALA A  46
LEU A 105
MET A 106
LEU A 156
 ATP  A 381 (-3.5A)
None
None
ATP  A 381 ( 4.8A)
 0.25A 4xoyA-2phkA:
26.0		 4xoyA-2phkA:
29.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 ALA A 176
LEU A 180
MET A 181
LEU A 239
 None
 1.13A 4xoyA-2pmiA:
11.8		 4xoyA-2pmiA:
33.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qb0 TELSAM DOMAIN -
LYSOZYME CHIMERA

(Escherichia
virus T4) 		PF00959
(Phage_lysozyme)
PF02198
(SAM_PNT) 		4 ALA B  35
GLN B  36
LEU B  38
LEU B  22
 None
 1.19A 4xoyA-2qb0B:
undetectable		 4xoyA-2qb0B:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ALA A 749
LEU A 798
MET A 799
LEU A 850
 GW7  A   1 (-3.3A)
GW7  A   1 (-4.5A)
None
GW7  A   1 (-4.2A)
 0.46A 4xoyA-2r4bA:
21.1		 4xoyA-2r4bA:
24.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wnt RIBOSOMAL PROTEIN S6
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A 445
LEU A 491
MET A 492
LEU A 542
 None
 0.83A 4xoyA-2wntA:
21.4		 4xoyA-2wntA:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xk9 CHECKPOINT KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A 247
LEU A 303
MET A 304
LEU A 354
 XK9  A1511 ( 4.1A)
XK9  A1511 (-4.1A)
None
XK9  A1511 (-4.6A)
 0.24A 4xoyA-2xk9A:
23.8		 4xoyA-2xk9A:
31.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A  51
LEU A 109
MET A 110
LEU A 160
 B49  A1294 (-3.2A)
B49  A1294 ( 4.7A)
None
B49  A1294 (-4.4A)
 0.18A 4xoyA-2y7jA:
11.1		 4xoyA-2y7jA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bb8 CDP-4-KETO-6-DEOXY-D
-GLUCOSE-3-DEHYDRASE

(Yersinia
pseudotuberculosis) 		PF01041
(DegT_DnrJ_EryC1) 		4 ALA A 301
GLN A 302
LEU A  48
MET A  49
 None
 1.01A 4xoyA-3bb8A:
undetectable		 4xoyA-3bb8A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bg0 NUCLEOPORIN NUP145

(Saccharomyces
cerevisiae) 		PF12110
(Nup96) 		4 ALA B 540
GLN B 541
LEU B 536
LEU B 527
 None
 0.90A 4xoyA-3bg0B:
undetectable		 4xoyA-3bg0B:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c49 POLY(ADP-RIBOSE)
POLYMERASE 3

(Homo sapiens) 		PF00644
(PARP)
PF02877
(PARP_reg) 		4 ALA A 281
GLN A 280
LEU A 278
LEU A 233
 None
 1.12A 4xoyA-3c49A:
undetectable		 4xoyA-3c49A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clh 3-DEHYDROQUINATE
SYNTHASE

(Helicobacter
pylori) 		PF01761
(DHQ_synthase) 		4 ALA A 123
GLN A 124
LEU A 122
LEU A 163
 NAD  A 400 ( 4.6A)
None
NAD  A 400 (-3.7A)
NAD  A 400 (-4.7A)
 1.07A 4xoyA-3clhA:
undetectable		 4xoyA-3clhA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d5f PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 ALA A 328
LEU A 442
MET A 439
LEU A 435
 None
 1.14A 4xoyA-3d5fA:
undetectable		 4xoyA-3d5fA:
20.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dfa CALCIUM-DEPENDENT
PROTEIN KINASE
CGD3_920

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		4 ALA A  34
LYS A  36
LEU A  85
LEU A 136
 None
 0.84A 4xoyA-3dfaA:
8.2		 4xoyA-3dfaA:
32.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fme DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A  80
LEU A 131
MET A 132
LEU A 186
 STU  A   1 (-3.4A)
STU  A   1 (-4.6A)
None
STU  A   1 (-4.4A)
 0.20A 4xoyA-3fmeA:
21.0		 4xoyA-3fmeA:
26.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gqp HEMOGLOBIN SUBUNIT
ALPHA

(Felis catus) 		PF00042
(Globin) 		4 ALA A  69
GLN A  68
LEU A  76
LEU A  83
 None
None
None
HEM  A 143 ( 4.4A)
 1.01A 4xoyA-3gqpA:
undetectable		 4xoyA-3gqpA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbu SECRETED PROTEASE C

(Dickeya
chrysanthemi) 		PF00353
(HemolysinCabind)
PF00413
(Peptidase_M10)
PF08548
(Peptidase_M10_C) 		4 ALA P 472
LYS P 409
GLN P 471
LEU P 441
 None
 1.07A 4xoyA-3hbuP:
undetectable		 4xoyA-3hbuP:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hs0 COBRA VENOM FACTOR

(Naja kaouthia) 		PF01759
(NTR)
PF07677
(A2M_recep) 		4 ALA C1340
LYS C1338
LEU C1341
MET C1342
 None
 1.14A 4xoyA-3hs0C:
undetectable		 4xoyA-3hs0C:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6u SERINE/THREONINE-PRO
TEIN KINASE CHK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00498
(FHA) 		4 ALA A 247
LEU A 303
MET A 304
LEU A 354
 None
 0.56A 4xoyA-3i6uA:
23.1		 4xoyA-3i6uA:
26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ifq PLAKOGLOBIN

(Homo sapiens) 		PF00514
(Arm) 		4 ALA A 314
GLN A 317
LEU A 315
LEU A 285
 None
 1.09A 4xoyA-3ifqA:
undetectable		 4xoyA-3ifqA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ij5 3-DEOXY-D-MANNO-OCTU
LOSONATE 8-PHOSPHATE
PHOSPHATASE

(Yersinia pestis) 		PF08282
(Hydrolase_3) 		4 ALA A  22
GLN A 176
LEU A 171
LEU A  64
 None
 1.19A 4xoyA-3ij5A:
undetectable		 4xoyA-3ij5A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ij6 UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE

(Lactobacillus
acidophilus) 		PF04909
(Amidohydro_2) 		4 ALA A 226
LYS A 230
GLN A 227
LEU A 221
 None
 1.18A 4xoyA-3ij6A:
undetectable		 4xoyA-3ij6A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ils AFLATOXIN
BIOSYNTHESIS
POLYKETIDE SYNTHASE

(Aspergillus
parasiticus) 		PF00975
(Thioesterase) 		4 ALA A1943
LEU A1871
MET A1870
LEU A1868
 None
 1.03A 4xoyA-3ilsA:
undetectable		 4xoyA-3ilsA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iqd OCTOPINE
DEHYDROGENASE

(Pecten maximus) 		PF02317
(Octopine_DH) 		4 ALA B 119
GLN B 118
LEU B 204
MET B 203
 None
 1.10A 4xoyA-3iqdB:
undetectable		 4xoyA-3iqdB:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3juj UDP-GLUCOSE
PYROPHOSPHORYLASE
(GALU)

(Helicobacter
pylori) 		PF00483
(NTP_transferase) 		4 ALA A 129
LEU A  35
MET A  27
LEU A  62
 None
 0.99A 4xoyA-3jujA:
undetectable		 4xoyA-3jujA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k0z PUTATIVE POLYKETIDE
CYCLASE

(Bacillus cereus) 		PF07366
(SnoaL) 		4 ALA A  52
LYS A  28
GLN A  49
LEU A  47
 None
 1.00A 4xoyA-3k0zA:
undetectable		 4xoyA-3k0zA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l12 PUTATIVE
GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Ruegeria
pomeroyi) 		PF03009
(GDPD) 		4 ALA A 239
GLN A 238
LEU A 236
LEU A 268
 None
 1.18A 4xoyA-3l12A:
undetectable		 4xoyA-3l12A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ALA A 719
LEU A 768
MET A 769
LEU A 820
 ITI  A   1 (-2.9A)
ITI  A   1 (-4.8A)
ITI  A   1 (-4.8A)
ITI  A   1 (-4.6A)
 0.88A 4xoyA-3lzbA:
20.7		 4xoyA-3lzbA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3njb ENOYL-COA HYDRATASE

(Mycolicibacterium
smegmatis) 		PF00378
(ECH_1) 		4 ALA A 209
GLN A 208
LEU A 214
LEU A 197
 None
 1.14A 4xoyA-3njbA:
undetectable		 4xoyA-3njbA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nxs LAO/AO TRANSPORT
SYSTEM ATPASE

(Mycolicibacterium
smegmatis) 		PF03308
(ArgK) 		4 ALA A  40
GLN A  39
LEU A  44
LEU A  10
 None
 1.20A 4xoyA-3nxsA:
undetectable		 4xoyA-3nxsA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		4 ALA A 213
LEU A 265
MET A 266
LEU A 318
 AMP  A 577 (-3.4A)
AMP  A 577 ( 4.9A)
None
AMP  A 577 (-4.8A)
 0.38A 4xoyA-3nyoA:
26.8		 4xoyA-3nyoA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE

(Escherichia
coli) 		PF03738
(GSP_synth)
PF05257
(CHAP) 		4 ALA A 531
LYS A 533
GLN A 568
LEU A 570
 ADP  A3001 (-3.6A)
ADP  A3001 (-2.8A)
ADP  A3001 (-4.0A)
ADP  A3001 (-4.3A)
 1.02A 4xoyA-3o98A:
undetectable		 4xoyA-3o98A:
21.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pg1 MITOGEN-ACTIVATED
PROTEIN KINASE,
PUTATIVE (MAP
KINASE-LIKE PROTEIN)

(Leishmania
major) 		PF00069
(Pkinase) 		4 ALA A  49
LEU A 114
MET A 115
LEU A 165
 None
 0.78A 4xoyA-3pg1A:
11.8		 4xoyA-3pg1A:
39.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ALA A 751
LEU A 800
MET A 801
LEU A 852
 03Q  A   1 (-3.1A)
03Q  A   1 (-4.6A)
None
03Q  A   1 (-4.4A)
 0.43A 4xoyA-3pp0A:
22.1		 4xoyA-3pp0A:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sbq NITROUS-OXIDE
REDUCTASE

(Pseudomonas
stutzeri) 		no annotation 4 ALA A 451
GLN A 472
LEU A 449
LEU A 425
 None
 1.14A 4xoyA-3sbqA:
2.3		 4xoyA-3sbqA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sv0 CASEIN KINASE I-LIKE

(Oryza sativa) 		PF00069
(Pkinase) 		4 ALA A  36
LYS A  38
LEU A  84
LEU A 135
 None
 0.74A 4xoyA-3sv0A:
17.8		 4xoyA-3sv0A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swv BREFELDIN
A-INHIBITED GUANINE
NUCLEOTIDE-EXCHANGE
PROTEIN 2

(Homo sapiens) 		PF01369
(Sec7) 		4 ALA A 679
GLN A 680
LEU A 682
LEU A 671
 None
 1.11A 4xoyA-3swvA:
undetectable		 4xoyA-3swvA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vn9 DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A  80
LEU A 131
MET A 132
LEU A 186
 ANK  A 401 (-3.0A)
None
None
ANK  A 401 ( 4.9A)
 0.44A 4xoyA-3vn9A:
21.2		 4xoyA-3vn9A:
25.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II

(Ascaris suum) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 ALA A 242
GLN A 497
MET A 553
LEU A 549
 None
 1.17A 4xoyA-3vrbA:
undetectable		 4xoyA-3vrbA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w04 DWARF 88 ESTERASE

(Oryza sativa) 		PF12697
(Abhydrolase_6) 		4 ALA A 308
GLN A 309
LEU A 311
LEU A 292
 None
 1.13A 4xoyA-3w04A:
undetectable		 4xoyA-3w04A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ALA A1978
LEU A2028
MET A2029
LEU A2086
 VGH  A3000 (-3.4A)
VGH  A3000 ( 4.8A)
None
VGH  A3000 (-4.3A)
 0.22A 4xoyA-3zbfA:
12.8		 4xoyA-3zbfA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgq INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 5

(Homo sapiens) 		PF07719
(TPR_2)
PF13181
(TPR_8)
PF13374
(TPR_10)
PF13424
(TPR_12) 		4 ALA A  77
GLN A  76
LEU A  51
LEU A  42
 None
 1.20A 4xoyA-3zgqA:
undetectable		 4xoyA-3zgqA:
20.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A  82
LEU A 139
MET A 140
LEU A 189
 R4L  A1394 ( 3.7A)
R4L  A1394 ( 4.9A)
None
R4L  A1394 (-4.5A)
 0.46A 4xoyA-4b99A:
16.0		 4xoyA-4b99A:
46.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0r PUTATIVE AMINO ACID
BINDING PROTEIN

(Streptococcus
mutans) 		PF00497
(SBP_bac_3) 		4 ALA A   8
GLN A  47
LEU A   7
LEU A  24
 None
CD  A1247 (-2.9A)
None
None
 1.19A 4xoyA-4c0rA:
undetectable		 4xoyA-4c0rA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cql ESTRADIOL
17-BETA-DEHYDROGENAS
E 8

(Homo sapiens) 		PF13561
(adh_short_C2) 		4 ALA A 139
GLN A 140
LEU A 142
LEU A  86
 None
 1.09A 4xoyA-4cqlA:
undetectable		 4xoyA-4cqlA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d9i DIAMINOPROPIONATE
AMMONIA-LYASE

(Escherichia
coli) 		PF00291
(PALP) 		4 ALA A 130
GLN A 133
MET A  78
LEU A  73
 None
 1.08A 4xoyA-4d9iA:
undetectable		 4xoyA-4d9iA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fek PUTATIVE DIFLAVIN
FLAVOPROTEIN A 5

(Nostoc sp. PCC
7120) 		no annotation 4 ALA A 245
GLN A 244
LEU A 242
LEU A 216
 None
 1.14A 4xoyA-4fekA:
undetectable		 4xoyA-4fekA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ALA A1148
LEU A1198
MET A1199
LEU A1256
 0UV  A1501 (-3.4A)
0UV  A1501 ( 4.8A)
None
0UV  A1501 (-4.6A)
 0.24A 4xoyA-4fodA:
22.1		 4xoyA-4fodA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzw 2,3-DEHYDROADIPYL-CO
A HYDRATASE

(Escherichia
coli) 		PF00378
(ECH_1) 		4 ALA A 168
GLN A 170
LEU A 173
LEU A 152
 None
 0.93A 4xoyA-4fzwA:
undetectable		 4xoyA-4fzwA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g54 GENERAL SECRETION
PATHWAY PROTEIN

(Vibrio
vulnificus) 		PF01471
(PG_binding_1) 		4 ALA A 516
GLN A 505
LEU A 521
LEU A 479
 None
 1.15A 4xoyA-4g54A:
undetectable		 4xoyA-4g54A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ka8 OLIGOPEPTIDASE A

(Arabidopsis
thaliana) 		PF01432
(Peptidase_M3) 		4 ALA A 719
GLN A 605
LEU A 722
LEU A 778
 None
GOL  A 803 (-4.9A)
GOL  A 805 ( 4.8A)
None
 0.98A 4xoyA-4ka8A:
undetectable		 4xoyA-4ka8A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kem MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Azospirillum
lipoferum) 		PF13378
(MR_MLE_C) 		4 ALA A  11
LEU A 386
MET A 383
LEU A 379
 None
 1.19A 4xoyA-4kemA:
undetectable		 4xoyA-4kemA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4llr TRYPAREDOXIN
PEROXIDASE

(Trypanosoma
cruzi) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		4 ALA A  12
GLN A 137
LEU A 139
LEU A  39
 None
 0.82A 4xoyA-4llrA:
undetectable		 4xoyA-4llrA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ls9 DHH FAMILY PROTEIN

(Mycolicibacterium
smegmatis) 		PF01368
(DHH)
PF02272
(DHHA1) 		4 ALA A  60
GLN A  61
LEU A  63
LEU A 163
 None
 1.11A 4xoyA-4ls9A:
undetectable		 4xoyA-4ls9A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00169
(PH)
PF00615
(RGS) 		4 ALA A 218
LEU A 273
MET A 274
LEU A 324
 29X  A 702 (-3.1A)
29X  A 702 (-4.6A)
None
29X  A 702 (-4.6A)
 0.42A 4xoyA-4mk0A:
19.4		 4xoyA-4mk0A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mxw LYMPHOTOXIN-BETA

(Homo sapiens) 		no annotation 4 ALA Y 126
GLN Y 118
LEU Y 127
LEU Y 113
 None
 0.97A 4xoyA-4mxwY:
undetectable		 4xoyA-4mxwY:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		4 ALA A 644
LYS A 646
MET A 695
LEU A 746
 None
 0.81A 4xoyA-4p2kA:
9.5		 4xoyA-4p2kA:
26.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pqj PHOSPHATE BINDING
PROTEIN

(Pseudomonas
aeruginosa) 		PF12849
(PBP_like_2) 		4 ALA A 286
LYS A 290
GLN A 287
LEU A 281
 None
 1.20A 4xoyA-4pqjA:
undetectable		 4xoyA-4pqjA:
21.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qtb MITOGEN-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  69
GLN A 122
LEU A 124
MET A 125
LEU A 173
 38Z  A 418 (-3.4A)
38Z  A 418 (-3.7A)
38Z  A 418 ( 4.8A)
None
38Z  A 418 (-4.4A)
 0.21A 4xoyA-4qtbA:
19.0		 4xoyA-4qtbA:
85.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8p TALIN-1
AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER
1-INTERACTING
PROTEIN

(Mus musculus;
Mus musculus) 		no annotation
no annotation 		4 ALA A1529
LEU B  22
MET B  19
LEU B  15
 None
EDO  A1702 ( 4.7A)
EDO  A1701 (-3.8A)
EDO  A1701 ( 4.8A)
 1.14A 4xoyA-4w8pA:
undetectable		 4xoyA-4w8pA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 ALA A 428
LYS A 430
MET A 477
LEU A 528
 None
 0.48A 4xoyA-4xi2A:
undetectable		 4xoyA-4xi2A:
21.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xrl MITOGEN-ACTIVATED
PROTEIN KINASE 1

(Rattus
norvegicus) 		PF00069
(Pkinase) 		5 ALA A  50
GLN A 103
LEU A 105
MET A 106
LEU A 154
 42A  A 402 (-3.2A)
42A  A 402 (-3.9A)
42A  A 402 ( 4.9A)
None
42A  A 402 ( 4.9A)
 0.19A 4xoyA-4xrlA:
49.7		 4xoyA-4xrlA:
99.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zo4 DEPHOSPHO-COA KINASE

(Campylobacter
jejuni) 		PF01121
(CoaE) 		4 ALA A 154
LEU A 150
MET A 145
LEU A 141
 None
 1.15A 4xoyA-4zo4A:
undetectable		 4xoyA-4zo4A:
21.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4zsl MITOGEN-ACTIVATED
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A  82
LEU A 139
MET A 140
LEU A 189
 None
 0.40A 4xoyA-4zslA:
37.6		 4xoyA-4zslA:
48.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		4 ALA A  90
LEU A 146
MET A 147
LEU A 196
 None
 0.32A 4xoyA-5ci6A:
37.7		 4xoyA-5ci6A:
49.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g06 EXOSOME COMPLEX
COMPONENT RRP4

(Saccharomyces
cerevisiae) 		PF14382
(ECR1_N)
PF15985
(KH_6) 		4 ALA H 301
LYS H 305
LEU H 233
MET H 198
 None
 1.19A 4xoyA-5g06H:
undetectable		 4xoyA-5g06H:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ALA A 743
LEU A 792
MET A 793
LEU A 844
 6HJ  A1101 (-3.1A)
6HJ  A1101 ( 4.9A)
None
6HJ  A1101 ( 4.8A)
 0.21A 4xoyA-5j9zA:
22.6		 4xoyA-5j9zA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlg RENIN

(Rattus
norvegicus) 		no annotation 4 ALA A 263
GLN A 242
LEU A 356
LEU A  55
 None
 1.13A 4xoyA-5mlgA:
undetectable		 4xoyA-5mlgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mmj 30S RIBOSOMAL
PROTEIN 3,
CHLOROPLASTIC

(Spinacia
oleracea) 		no annotation 4 ALA w 163
GLN w 162
LEU w 112
LEU w 114
 None
 1.16A 4xoyA-5mmjw:
undetectable		 4xoyA-5mmjw:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n8o DNA HELICASE I

(Escherichia
coli) 		PF07057
(TraI)
PF08751
(TrwC)
PF13604
(AAA_30) 		4 ALA A 323
GLN A 322
LEU A 327
LEU A 646
 None
 1.14A 4xoyA-5n8oA:
undetectable		 4xoyA-5n8oA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		4 ALA A 218
LEU A 273
MET A 274
LEU A 324
 QRW  A 601 (-3.4A)
None
MES  A 604 (-3.9A)
None
 0.41A 4xoyA-5uuuA:
25.5		 4xoyA-5uuuA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yq3 AT3G55470

(Arabidopsis
thaliana) 		no annotation 4 ALA A  61
GLN A 138
LEU A   6
LEU A 136
 None
 1.09A 4xoyA-5yq3A:
undetectable		 4xoyA-5yq3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bwm TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 2

(Oryctolagus
cuniculus) 		no annotation 4 ALA A 235
GLN A 233
LEU A 212
LEU A 166
 None
 1.19A 4xoyA-6bwmA:
undetectable		 4xoyA-6bwmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cc2 CELL DIVISION
CONTROL PROTEIN 45
CDC45 PUTATIVE

(Entamoeba
histolytica) 		no annotation 4 ALA A 451
GLN A 452
LEU A 454
LEU A 407
 None
None
None
CL  A 614 ( 4.9A)
 1.17A 4xoyA-6cc2A:
undetectable		 4xoyA-6cc2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cxd PEPTIDASE B

(Yersinia pestis) 		no annotation 4 ALA A 331
GLN A 330
LEU A 328
LEU A 321
 None
 1.17A 4xoyA-6cxdA:
undetectable		 4xoyA-6cxdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 4 ALA A 217
LEU A 266
MET A 267
LEU A 319
 FKY  A9001 (-3.3A)
FKY  A9001 (-4.4A)
None
FKY  A9001 ( 4.9A)
 0.36A 4xoyA-6cz4A:
21.6		 4xoyA-6cz4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gu8 -

(-) 		no annotation 4 ALA A 329
LEU A 332
MET A 333
LEU A 338
 None
 1.06A 4xoyA-6gu8A:
undetectable		 4xoyA-6gu8A:
undetectable