SIMILAR PATTERNS OF AMINO ACIDS FOR 4XO7_B_ASDB402_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b4e PROTEIN
(5-AMINOLEVULINIC
ACID DEHYDRATASE)

(Escherichia
coli) 		PF00490
(ALAD) 		4 TYR A 276
VAL A 294
ILE A 322
LEU A  33
 None
 1.23A 4xo7B-1b4eA:
10.5		 4xo7B-1b4eA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cli PROTEIN
(PHOSPHORIBOSYL-AMIN
OIMIDAZOLE
SYNTHETASE)

(Escherichia
coli) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 TYR A 194
VAL A  67
ILE A  85
LEU A  77
 None
 0.94A 4xo7B-1cliA:
undetectable		 4xo7B-1cliA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d8c MALATE SYNTHASE G

(Escherichia
coli) 		PF01274
(Malate_synthase) 		4 TYR A 548
VAL A 553
ILE A 504
HIS A 544
 None
 1.18A 4xo7B-1d8cA:
6.2		 4xo7B-1d8cA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fcu HYALURONOGLUCOSAMINI
DASE

(Apis mellifera) 		PF01630
(Glyco_hydro_56) 		4 VAL A  17
TRP A  15
ILE A  38
LEU A 278
 None
 1.24A 4xo7B-1fcuA:
2.7		 4xo7B-1fcuA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1guq GALACTOSE-1-PHOSPHAT
E
URIDYLYLTRANSFERASE

(Escherichia
coli) 		PF01087
(GalP_UDP_transf)
PF02744
(GalP_UDP_tr_C) 		4 TYR A 276
TRP A 134
ILE A 130
LEU A 262
 None
 1.17A 4xo7B-1guqA:
undetectable		 4xo7B-1guqA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k4n PROTEIN EC4020

(Escherichia
coli) 		PF06185
(YecM) 		4 VAL A  90
ILE A  17
HIS A  46
LEU A  83
 None
 1.11A 4xo7B-1k4nA:
undetectable		 4xo7B-1k4nA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lam LEUCINE
AMINOPEPTIDASE

(Bos taurus) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		4 VAL A 410
ILE A 326
HIS A 447
LEU A 360
 None
None
None
CO3  A 500 ( 4.0A)
 1.14A 4xo7B-1lamA:
undetectable		 4xo7B-1lamA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lqt FPRA

(Mycobacterium
tuberculosis) 		PF07992
(Pyr_redox_2) 		4 VAL A 327
ILE A 360
HIS A 135
LEU A  42
 None
None
None
FAD  A2457 ( 4.3A)
 1.24A 4xo7B-1lqtA:
undetectable		 4xo7B-1lqtA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mox EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain) 		4 VAL A 124
TRP A 140
ILE A 143
LEU A  77
 None
 1.07A 4xo7B-1moxA:
undetectable		 4xo7B-1moxA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ovm INDOLE-3-PYRUVATE
DECARBOXYLASE

(Enterobacter
cloacae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 VAL A 459
TRP A 486
ILE A 489
LEU A 440
 None
 1.22A 4xo7B-1ovmA:
undetectable		 4xo7B-1ovmA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ru3 ACETYL-COA SYNTHASE

(Carboxydothermus
hydrogenoformans) 		PF03598
(CdhC) 		4 TYR A 257
VAL A 255
HIS A 261
LEU A 285
 None
 1.19A 4xo7B-1ru3A:
undetectable		 4xo7B-1ru3A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbr ENDO-1,4-BETA-XYLANA
SE B

(Thermotoga
maritima) 		PF00331
(Glyco_hydro_10) 		4 VAL A 601
TRP A 660
ILE A 664
TRP A 675
 None
 1.02A 4xo7B-1vbrA:
4.6		 4xo7B-1vbrA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vdh MUCONOLACTONE
ISOMERASE-LIKE
PROTEIN

(Thermus
thermophilus) 		PF06778
(Chlor_dismutase) 		4 VAL A 136
ILE A  64
TRP A  51
LEU A  86
 None
 1.22A 4xo7B-1vdhA:
undetectable		 4xo7B-1vdhA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xi8 MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN

(Pyrococcus
furiosus) 		PF00994
(MoCF_biosynth)
PF03453
(MoeA_N)
PF03454
(MoeA_C) 		4 TYR A 396
VAL A 370
HIS A 308
LEU A 219
 None
 1.22A 4xo7B-1xi8A:
undetectable		 4xo7B-1xi8A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygp YEAST GLYCOGEN
PHOSPHORYLASE

(Saccharomyces
cerevisiae) 		PF00343
(Phosphorylase) 		4 VAL A 482
ILE A 817
HIS A 450
TRP A 825
 None
 1.13A 4xo7B-1ygpA:
undetectable		 4xo7B-1ygpA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2atm HYALURONOGLUCOSAMINI
DASE

(Vespula
vulgaris) 		PF01630
(Glyco_hydro_56) 		4 VAL A  14
TRP A  12
ILE A  34
LEU A 273
 None
 1.17A 4xo7B-2atmA:
2.7		 4xo7B-2atmA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cxi PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Pyrococcus
horikoshii) 		PF03483
(B3_4)
PF03484
(B5) 		4 TYR A 289
VAL A 285
ILE A 332
LEU A 343
 None
 1.17A 4xo7B-2cxiA:
undetectable		 4xo7B-2cxiA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN

(Daboia
siamensis) 		PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		4 VAL A 211
ILE A  36
HIS A  95
LEU A  89
 None
 1.19A 4xo7B-2e3xA:
undetectable		 4xo7B-2e3xA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h2w HOMOSERINE
O-SUCCINYLTRANSFERAS
E

(Thermotoga
maritima) 		PF04204
(HTS) 		4 TYR A  89
ILE A 104
HIS A  84
LEU A   9
 None
 1.02A 4xo7B-2h2wA:
undetectable		 4xo7B-2h2wA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hq8 COELENTERAZINE-BINDI
NG PROTEIN CA-BOUND
APO FORM

(Renilla
muelleri) 		PF13202
(EF-hand_5)
PF13499
(EF-hand_7) 		4 TYR A 181
VAL A 131
ILE A  43
LEU A 147
 None
 1.22A 4xo7B-2hq8A:
undetectable		 4xo7B-2hq8A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2if6 HYPOTHETICAL PROTEIN
YIIX

(Escherichia
coli) 		PF05708
(Peptidase_C92) 		4 VAL A  62
TRP A  77
ILE A  78
TRP A  19
 None
 1.18A 4xo7B-2if6A:
undetectable		 4xo7B-2if6A:
21.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ipj ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		6 VAL A  54
TRP A  86
ILE A 129
HIS A 222
TRP A 227
LEU A 306
 FFA  A 325 (-4.8A)
None
None
NAP  A   1 ( 4.8A)
FFA  A 325 (-3.8A)
FFA  A 325 (-4.8A)
 0.83A 4xo7B-2ipjA:
56.3		 4xo7B-2ipjA:
99.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iw0 CHITIN DEACETYLASE

(Colletotrichum
lindemuthianum) 		PF01522
(Polysacc_deac_1) 		4 VAL A  74
ILE A 133
HIS A  99
LEU A  60
 None
 1.24A 4xo7B-2iw0A:
4.3		 4xo7B-2iw0A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nya PERIPLASMIC NITRATE
REDUCTASE

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 VAL A 384
ILE A 136
TRP A 115
LEU A 523
 None
 1.23A 4xo7B-2nyaA:
undetectable		 4xo7B-2nyaA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ocf ESTROGEN RECEPTOR
FIBRONECTIN

(Homo sapiens) 		PF00041
(fn3)
PF00104
(Hormone_recep) 		4 TYR D  73
ILE D  59
HIS A 356
LEU A 327
 None
 1.14A 4xo7B-2ocfD:
undetectable		 4xo7B-2ocfD:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qma DIAMINOBUTYRATE-PYRU
VATE TRANSAMINASE
AND
L-2,4-DIAMINOBUTYRAT
E DECARBOXYLASE

(Vibrio
parahaemolyticus) 		PF00282
(Pyridoxal_deC) 		4 TYR A 614
VAL A 774
ILE A 735
LEU A 764
 None
 1.22A 4xo7B-2qmaA:
undetectable		 4xo7B-2qmaA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qsw METHIONINE IMPORT
ATP-BINDING PROTEIN
METN 2

(Enterococcus
faecalis) 		PF09383
(NIL) 		4 VAL A 294
ILE A 316
HIS A 287
LEU A 335
 None
None
ZN  A 202 ( 3.2A)
None
 1.20A 4xo7B-2qswA:
undetectable		 4xo7B-2qswA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpw THIOSULFATE
REDUCTASE

(Thermus
thermophilus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 VAL A 315
TRP A 264
ILE A 307
LEU A 205
 None
 1.08A 4xo7B-2vpwA:
undetectable		 4xo7B-2vpwA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xb0 CHROMO
DOMAIN-CONTAINING
PROTEIN 1

(Saccharomyces
cerevisiae) 		PF13921
(Myb_DNA-bind_6) 		4 TRP X 191
ILE X 206
TRP X 171
LEU X 256
 None
 1.17A 4xo7B-2xb0X:
undetectable		 4xo7B-2xb0X:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding) 		4 TYR A 123
VAL A 116
ILE A 164
LEU A 179
 None
EDO  A1753 ( 4.7A)
None
None
 1.08A 4xo7B-2xijA:
6.0		 4xo7B-2xijA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3acf BETA-1,4-ENDOGLUCANA
SE

([Clostridium]
josui) 		PF03424
(CBM_17_28) 		4 TYR A  69
VAL A  48
ILE A  84
LEU A 105
 None
 0.99A 4xo7B-3acfA:
undetectable		 4xo7B-3acfA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3acf BETA-1,4-ENDOGLUCANA
SE

([Clostridium]
josui) 		PF03424
(CBM_17_28) 		4 TYR A  69
VAL A  48
TRP A  42
ILE A  84
 None
 1.12A 4xo7B-3acfA:
undetectable		 4xo7B-3acfA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmb ACETOACETATE
DECARBOXYLASE

(Methanoculleus
marisnigri) 		PF06314
(ADC) 		4 VAL A 103
TRP A 105
ILE A  81
LEU A 238
 None
 1.12A 4xo7B-3cmbA:
undetectable		 4xo7B-3cmbA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e77 PHOSPHOSERINE
AMINOTRANSFERASE

(Homo sapiens) 		PF00266
(Aminotran_5) 		4 TYR A 150
VAL A 102
TRP A 140
ILE A 134
 None
 1.19A 4xo7B-3e77A:
undetectable		 4xo7B-3e77A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3el6 ERYTHROMYCIN
DEHYDRATASE

(Saccharopolyspora
erythraea) 		PF14765
(PS-DH) 		4 TYR A 198
VAL A 203
HIS A  12
LEU A  60
 None
 1.09A 4xo7B-3el6A:
undetectable		 4xo7B-3el6A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fai BETA-LACTAMASE

(Aeromonas
hydrophila) 		PF00753
(Lactamase_B) 		4 VAL A 112
TRP A 128
ILE A 131
LEU A  45
 None
 1.08A 4xo7B-3faiA:
undetectable		 4xo7B-3faiA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdn R-OXYNITRILE LYASE
ISOENZYME 1

(Prunus dulcis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 TYR A 457
ILE A 406
HIS A 497
LEU A 319
 HBX  A 530 (-4.3A)
None
HBX  A 530 ( 3.9A)
None
 1.24A 4xo7B-3gdnA:
undetectable		 4xo7B-3gdnA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h3b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF01030
(Recep_L_domain) 		4 VAL A 131
TRP A 147
ILE A 150
LEU A  74
 None
 1.10A 4xo7B-3h3bA:
undetectable		 4xo7B-3h3bA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9c METHIONYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF09334
(tRNA-synt_1g) 		4 TYR A 260
ILE A 109
HIS A 291
LEU A 289
 None
 1.24A 4xo7B-3h9cA:
undetectable		 4xo7B-3h9cA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A

(Drosophila
melanogaster) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		4 VAL A 429
TRP A 445
ILE A 448
LEU A 384
 None
 1.00A 4xo7B-3i2tA:
undetectable		 4xo7B-3i2tA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1u BETA-XYLOSIDASE,
FAMILY 43 GLYCOSYL
HYDROLASE

(Clostridium
acetobutylicum) 		PF04616
(Glyco_hydro_43) 		4 TYR A 220
VAL A 194
ILE A 162
HIS A 277
 TRS  A 801 (-4.6A)
None
None
TRS  A 801 (-4.5A)
 1.21A 4xo7B-3k1uA:
undetectable		 4xo7B-3k1uA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lax PHENYLACETATE-COENZY
ME A LIGASE

(Bacteroides
vulgatus) 		PF14535
(AMP-binding_C_2) 		4 TYR A 356
VAL A 371
ILE A 401
LEU A 347
 None
 1.12A 4xo7B-3laxA:
undetectable		 4xo7B-3laxA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ly9 TRANSCRIPTIONAL
ACTIVATOR CADC

(Escherichia
coli) 		no annotation 4 TYR A 341
ILE A 259
HIS A 344
LEU A 348
 None
 1.25A 4xo7B-3ly9A:
undetectable		 4xo7B-3ly9A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nng UNCHARACTERIZED
PROTEIN

(Bacteroides
fragilis) 		PF00754
(F5_F8_type_C) 		4 TYR A 334
VAL A 194
TRP A 199
ILE A 220
 None
 1.25A 4xo7B-3nngA:
undetectable		 4xo7B-3nngA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nt8 ANCYLOSTOMA SECRETED
PROTEIN 1

(Necator
americanus) 		PF00188
(CAP) 		4 TYR A 177
ILE A  86
HIS A  44
LEU A 123
 None
 1.23A 4xo7B-3nt8A:
undetectable		 4xo7B-3nt8A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ob8 BETA-GALACTOSIDASE

(Kluyveromyces
lactis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N) 		4 VAL A 418
ILE A  97
HIS A 489
LEU A 413
 None
 1.03A 4xo7B-3ob8A:
8.9		 4xo7B-3ob8A:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odg XANTHOSINE
PHOSPHORYLASE

(Yersinia
pseudotuberculosis) 		PF01048
(PNP_UDP_1) 		4 TYR A 172
ILE A  39
HIS A 144
LEU A 230
 None
 0.91A 4xo7B-3odgA:
undetectable		 4xo7B-3odgA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odg XANTHOSINE
PHOSPHORYLASE

(Yersinia
pseudotuberculosis) 		PF01048
(PNP_UDP_1) 		4 TYR A 172
VAL A 239
ILE A  39
HIS A 144
 None
 1.18A 4xo7B-3odgA:
undetectable		 4xo7B-3odgA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oft CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		4 VAL A 214
TRP A 219
ILE A 209
HIS A  94
 None
None
None
HEM  A 417 (-4.0A)
 1.11A 4xo7B-3oftA:
undetectable		 4xo7B-3oftA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p11 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		4 VAL A 128
TRP A 144
ILE A 147
LEU A  78
 None
 1.05A 4xo7B-3p11A:
undetectable		 4xo7B-3p11A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p11 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		4 VAL A 128
TRP A 144
ILE A 147
LEU A  80
 None
 1.12A 4xo7B-3p11A:
undetectable		 4xo7B-3p11A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pps LACCASE

(Thielavia
arenaria) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 VAL A  58
TRP A  47
ILE A  48
LEU A 200
 None
 1.20A 4xo7B-3ppsA:
undetectable		 4xo7B-3ppsA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3puk SYNTAXIN-BINDING
PROTEIN 3

(Mus musculus) 		PF00995
(Sec1) 		4 VAL A 147
ILE A 534
HIS A 566
LEU A 568
 None
 1.13A 4xo7B-3pukA:
undetectable		 4xo7B-3pukA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qkw NUCLEOTIDE SUGAR
SYNTHETASE-LIKE
PROTEIN

(Streptococcus
parasanguinis) 		no annotation 4 TYR A 245
ILE A  13
HIS A 156
LEU A 218
 UDP  A 400 (-4.7A)
None
UDP  A 400 (-4.9A)
None
 0.99A 4xo7B-3qkwA:
undetectable		 4xo7B-3qkwA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tny YFIY (ABC TRANSPORT
SYSTEM
SUBSTRATE-BINDING
PROTEIN)

(Bacillus cereus) 		PF01497
(Peripla_BP_2) 		4 VAL A  63
TRP A  52
ILE A  56
LEU A  25
 None
 1.02A 4xo7B-3tnyA:
undetectable		 4xo7B-3tnyA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u2p RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain) 		4 VAL A 122
TRP A 138
ILE A 141
LEU A  72
 None
 0.96A 4xo7B-3u2pA:
undetectable		 4xo7B-3u2pA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u2p RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain) 		4 VAL A 122
TRP A 138
ILE A 141
LEU A  74
 None
 1.08A 4xo7B-3u2pA:
undetectable		 4xo7B-3u2pA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7u RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		4 VAL A 122
TRP A 138
ILE A 141
LEU A  72
 None
 0.93A 4xo7B-3u7uA:
undetectable		 4xo7B-3u7uA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wiq KOJIBIOSE
PHOSPHORYLASE

(Caldicellulosiruptor
saccharolyticus) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		4 VAL A 126
ILE A  72
HIS A 313
LEU A  97
 None
 1.17A 4xo7B-3wiqA:
undetectable		 4xo7B-3wiqA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b4c CHROMODOMAIN-HELICAS
E-DNA-BINDING
PROTEIN 1

(Homo sapiens) 		no annotation 4 TRP A1273
ILE A1288
TRP A1253
LEU A1309
 None
 1.17A 4xo7B-4b4cA:
undetectable		 4xo7B-4b4cA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cgk SECRETED 45 KDA
PROTEIN

(Streptococcus
pneumoniae) 		PF05257
(CHAP) 		4 TYR A 287
VAL A 296
ILE A 389
TRP A 307
 None
 1.09A 4xo7B-4cgkA:
undetectable		 4xo7B-4cgkA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g68 ABC TRANSPORTER

(Caldanaerobius) 		PF01547
(SBP_bac_1) 		4 TYR B 301
TRP B 191
ILE B 380
LEU B 343
 None
XYP  B 802 (-4.2A)
None
None
 1.16A 4xo7B-4g68B:
undetectable		 4xo7B-4g68B:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jja HYPOTHETICAL PROTEIN

(Bacteroides
fragilis) 		PF07075
(DUF1343) 		4 TYR A 223
ILE A 157
HIS A 225
LEU A 384
 None
 1.07A 4xo7B-4jjaA:
undetectable		 4xo7B-4jjaA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4leo RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		4 VAL C 128
TRP C 144
ILE C 147
LEU C  78
 None
 1.02A 4xo7B-4leoC:
undetectable		 4xo7B-4leoC:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4leo RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		4 VAL C 128
TRP C 144
ILE C 147
LEU C  80
 None
 1.12A 4xo7B-4leoC:
undetectable		 4xo7B-4leoC:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nph PROBABLE SECRETION
SYSTEM APPARATUS ATP
SYNTHASE SSAN

(Salmonella
enterica) 		PF00006
(ATP-synt_ab) 		4 VAL A 346
ILE A 329
HIS A 362
LEU A 423
 None
 1.07A 4xo7B-4nphA:
undetectable		 4xo7B-4nphA:
26.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzp ARGININOSUCCINATE
SYNTHASE

(Campylobacter
jejuni) 		PF00764
(Arginosuc_synth) 		4 VAL A  33
ILE A 146
HIS A 167
TRP A  24
 None
 1.04A 4xo7B-4nzpA:
undetectable		 4xo7B-4nzpA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pt2 ENCAPSULIN PROTEIN

(Myxococcus
xanthus) 		no annotation 4 VAL P 216
ILE P 165
HIS P 194
LEU P 203
 None
 1.16A 4xo7B-4pt2P:
undetectable		 4xo7B-4pt2P:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qt4 PEPTIDYL-TRNA
HYDROLASE

(Streptococcus
pyogenes) 		PF01195
(Pept_tRNA_hydro) 		4 VAL A  90
ILE A 120
HIS A  20
LEU A  95
 None
 1.13A 4xo7B-4qt4A:
undetectable		 4xo7B-4qt4A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tvv TYROSINE PHOSPHATASE
II SUPERFAMILY
PROTEIN

(Legionella
pneumophila) 		PF14566
(PTPlike_phytase) 		4 VAL A 188
TRP A  85
ILE A  88
LEU A 108
 None
 1.07A 4xo7B-4tvvA:
undetectable		 4xo7B-4tvvA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xcp NEMATODE FATTY ACID
RETINOID BINDING
PROTEIN

(Necator
americanus) 		PF05823
(Gp-FAR-1) 		4 TYR A 100
VAL A  36
ILE A  49
LEU A  25
 PLM  A 201 (-4.5A)
None
PLM  A 202 ( 4.5A)
None
 1.09A 4xo7B-4xcpA:
undetectable		 4xo7B-4xcpA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster) 		PF00209
(SNF) 		4 TYR A 393
VAL A 362
ILE A 278
LEU A 414
 None
 1.18A 4xo7B-4xnuA:
undetectable		 4xo7B-4xnuA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y7i MYOTUBULARIN-RELATED
PROTEIN 8

(Homo sapiens) 		PF06602
(Myotub-related) 		4 VAL A 459
TRP A 460
ILE A 375
LEU A 403
 None
 1.17A 4xo7B-4y7iA:
undetectable		 4xo7B-4y7iA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yt9 PEPTIDYLARGININE
DEIMINASE

(Porphyromonas
gingivalis) 		PF04371
(PAD_porph) 		4 VAL A 237
TRP A 240
ILE A 251
HIS A 222
 4GJ  A 239 ( 4.9A)
GOL  A 508 (-3.6A)
None
None
 1.20A 4xo7B-4yt9A:
undetectable		 4xo7B-4yt9A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zlg PUTATIVE B-GLYCAN
PHOSPHORYLASE

(Saccharophagus
degradans) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 TYR A  71
TRP A 116
ILE A 114
HIS A  75
 None
 1.23A 4xo7B-4zlgA:
undetectable		 4xo7B-4zlgA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5djq CBB3-TYPE CYTOCHROME
C OXIDASE SUBUNIT
CCON1

(Pseudomonas
stutzeri) 		PF00115
(COX1) 		4 TYR A 363
VAL A 366
ILE A  19
HIS A 384
 None
 1.18A 4xo7B-5djqA:
undetectable		 4xo7B-5djqA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5du3 PLASMA PROTEASE C1
INHIBITOR

(Homo sapiens) 		PF00079
(Serpin) 		4 TYR A 132
VAL A 458
ILE A 360
HIS A 133
 None
 1.14A 4xo7B-5du3A:
undetectable		 4xo7B-5du3A:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fn7 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE C

(Homo sapiens) 		PF12567
(CD45) 		4 TYR A  22
VAL A  53
ILE A  66
HIS A 159
 None
 1.24A 4xo7B-5fn7A:
undetectable		 4xo7B-5fn7A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gha SULFUR TRANSFERASE
TTUA

(Thermus
thermophilus) 		PF01171
(ATP_bind_3) 		4 TYR A 114
VAL A 108
ILE A 141
LEU A 121
 None
 1.24A 4xo7B-5ghaA:
undetectable		 4xo7B-5ghaA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE

(Saccharomyces
cerevisiae) 		PF00067
(p450) 		4 VAL A 456
ILE A 452
HIS A 378
LEU A 383
 None
None
HEM  A 601 ( 4.9A)
HEM  A 601 (-4.0A)
 1.18A 4xo7B-5hs1A:
undetectable		 4xo7B-5hs1A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5d INNER MEMBRANE
PROTEIN YEJM

(Salmonella
enterica) 		PF00884
(Sulfatase)
PF11893
(DUF3413) 		4 VAL A 444
TRP A 477
ILE A 290
LEU A 309
 None
 1.17A 4xo7B-5i5dA:
undetectable		 4xo7B-5i5dA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig2 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Paraburkholderia
phymatum) 		PF00106
(adh_short) 		4 TYR A 156
VAL A 110
TRP A 109
LEU A 223
 ACT  A 302 ( 4.1A)
None
None
None
 1.13A 4xo7B-5ig2A:
2.3		 4xo7B-5ig2A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikk HISTONE DEACETYLASE
CLR3

(Schizosaccharomyces
pombe) 		PF00850
(Hist_deacetyl)
PF09757
(Arb2) 		4 VAL A 308
ILE A 404
TRP A 290
LEU A 339
 None
 1.23A 4xo7B-5ikkA:
undetectable		 4xo7B-5ikkA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE

([Candida]
glabrata) 		PF00067
(p450) 		4 VAL A 458
ILE A 454
HIS A 379
LEU A 384
 None
None
None
HEM  A 601 (-3.6A)
 1.22A 4xo7B-5jlcA:
undetectable		 4xo7B-5jlcA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ko5 PURINE NUCLEOSIDE
PHOSPHORYLASE

(Schistosoma
mansoni) 		PF01048
(PNP_UDP_1) 		4 TYR A 168
VAL A 237
ILE A  32
HIS A 137
 None
 1.07A 4xo7B-5ko5A:
undetectable		 4xo7B-5ko5A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE DELTA
SUBUNIT

(Aromatoleum
aromaticum) 		PF02538
(Hydantoinase_B) 		4 TYR A 668
VAL A 277
ILE A 363
LEU A 681
 None
 1.22A 4xo7B-5l9wA:
undetectable		 4xo7B-5l9wA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m28 MALE1

(Lactobacillus
casei) 		PF13416
(SBP_bac_8) 		4 TYR A 252
VAL A 169
ILE A 360
LEU A 156
 None
 0.97A 4xo7B-5m28A:
undetectable		 4xo7B-5m28A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8b ALPHA-L-ARABINOFURAN
OSIDASE II

(Lactobacillus
brevis) 		PF04616
(Glyco_hydro_43) 		4 TYR A 226
VAL A 200
ILE A 168
HIS A 283
 None
 1.17A 4xo7B-5m8bA:
undetectable		 4xo7B-5m8bA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o4g RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		no annotation 4 VAL C 131
TRP C 147
ILE C 150
LEU C  74
 None
 1.07A 4xo7B-5o4gC:
undetectable		 4xo7B-5o4gC:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oas MALATE SYNTHASE G

(Pseudomonas
aeruginosa) 		no annotation 4 TYR A 553
VAL A 558
ILE A 509
HIS A 549
 None
 1.12A 4xo7B-5oasA:
7.9		 4xo7B-5oasA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ogz -

(-) 		no annotation 4 VAL A 158
TRP A 161
ILE A 213
LEU A  98
 None
 1.20A 4xo7B-5ogzA:
10.5		 4xo7B-5ogzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t65 METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
PCTA

(Pseudomonas
aeruginosa) 		PF02743
(dCache_1) 		4 VAL A 254
TRP A 256
ILE A 248
LEU A 174
 None
 1.05A 4xo7B-5t65A:
undetectable		 4xo7B-5t65A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tfz DIMETHYLSULFONIOPROP
IONATE LYASE DDDK

(Candidatus
Pelagibacter
ubique) 		PF07883
(Cupin_2) 		4 TYR A 122
ILE A 111
HIS A  56
LEU A  53
 7BC  A 202 (-4.7A)
None
NI  A 201 ( 3.8A)
7BC  A 202 (-4.9A)
 1.22A 4xo7B-5tfzA:
undetectable		 4xo7B-5tfzA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uz5 PROTEIN LUC7
U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT PRP42

(Saccharomyces
cerevisiae) 		no annotation 4 VAL D  20
TRP D  30
HIS H  40
LEU D  55
 None
 1.23A 4xo7B-5uz5D:
undetectable		 4xo7B-5uz5D:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wee VENOM ALLERGEN LIKE
PROTEIN 4

(Heligmosomoides
polygyrus) 		no annotation 4 TYR A 152
ILE A  65
HIS A  23
LEU A  98
 None
 1.22A 4xo7B-5weeA:
undetectable		 4xo7B-5weeA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xqo PCRGLX PROTEIN

(Penicillium
chrysogenum) 		no annotation 4 TYR A 385
VAL A 276
ILE A 161
LEU A 383
 None
 1.20A 4xo7B-5xqoA:
undetectable		 4xo7B-5xqoA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zbb -

(-) 		no annotation 4 VAL A 452
TRP A 448
ILE A 427
HIS A 415
 None
 1.03A 4xo7B-5zbbA:
undetectable		 4xo7B-5zbbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zqj BETA-XYLOSIDASE

(Bacillus
pumilus) 		no annotation 4 TRP A 115
ILE A  39
HIS A 132
LEU A 130
 None
 1.19A 4xo7B-5zqjA:
undetectable		 4xo7B-5zqjA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6axe MALATE SYNTHASE G

(Mycobacterium
marinum) 		PF01274
(Malate_synthase) 		4 TYR A 559
VAL A 564
ILE A 515
HIS A 555
 None
 1.14A 4xo7B-6axeA:
9.7		 4xo7B-6axeA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eub ANGIOPOIETIN-RELATED
PROTEIN 4

(Homo sapiens) 		no annotation 4 VAL A 275
ILE A 227
TRP A 350
LEU A 304
 None
 1.22A 4xo7B-6eubA:
undetectable		 4xo7B-6eubA:
13.48